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Muscular fatigue

Michael R Deschenes, Shuhan Li, Matthew A Adan, Jane J Oh, Hailey C Ramsey
BACKGROUND: This project aimed to determine the adaptability of the neuromuscular system to the stimuli of exercise training, and aging. METHODS: Young adult, and aged male rats were randomly assigned to either exercise training, or sedentary control groups. Exercise training featured an 8 week program of treadmill running. At the end of the intervention period, neuromuscular function was quantified with ex vivo stimulation procedures on isolated soleus muscles...
March 14, 2018: Experimental Gerontology
Diogo Coutinho, Bruno Gonçalves, Del P Wong, Bruno Travassos, Aaron J Coutts, Jaime Sampaio
This study examined the effects of induced mental and muscular fatigue on soccer players' physical activity profile and collective behavior during small-sided games (SSG). Ten youth soccer players performed a 5vs5 SSG under three conditions: a) control, playing without any previous activity; b) muscular fatigue, playing after performing a repeated change-of-direction task; c) mental fatigue, playing after completing a 30 min Stroop color-word task. Players' positional data was used to compute time-motion and tactical-related variables...
March 14, 2018: Human Movement Science
Maria Siemionow, Joanna Cwykiel, Ahlke Heydemann, Jesus Garcia, Enza Marchese, Krzysztof Siemionow, Erzsebet Szilagyi
Duchenne Muscular Dystrophy (DMD) is a progressive and lethal disease caused by mutations of the dystrophin gene. Currently no cure exists. Stem cell therapies targeting DMD are challenged by limited engraftment and rejection despite the use of immunosuppression. There is an urgent need to introduce new stem cell-based therapies that exhibit low allogenic profiles and improved cell engraftment. In this proof-of-concept study, we develop and test a new human stem cell-based approach to increase engraftment, limit rejection, and restore dystrophin expression in the mdx/scid mouse model of DMD...
March 15, 2018: Stem Cell Reviews
Zhuming Yin, Liqiang Liu, Bingjian Xue, Jincai Fan, Wenlin Chen, Zheng Liu
INTRODUCTION: Prosthesis-assisted penile reconstruction has been performed extensively to restore a cosmetically acceptable phallus. However, a large number of patients will undergo revision surgery for various prosthesis-related complications. AIM: To develop a 1-stage prosthesis-free dynamic cavernosa reconstruction method using bilateral innervated gracilis muscles and to investigate the feasibility and reliability of the surgical design. METHODS: 10 fresh cadavers were dissected to assess the availability of bilateral gracilis muscles for functional cavernosa rebuilding...
March 7, 2018: Sexual Medicine
Amanda M Heapy, Martin D Hoffman, Heidie H Verhagen, Samuel W Thompson, Pavitra Dhamija, Fiona J Sandford, Mary C Cooper
Manual therapy (MT) and intermittent pneumatic compression (IPC) are recovery methods used by endurance athletes with little evidence supporting effectiveness. This randomized controlled trial evaluated effectiveness of four daily post-race treatments of a specific MT protocol and IPC compared with supine rest on recovery following an ultramarathon among 56 ultramarathoners. Groups were comparable across all characteristics examined, including post-race plasma creatine kinase concentration. Subject completed timed 400 m runs before the race and on days three, five, seven and 14 post- race, and also provided muscle pain and soreness ratings and fatigue scores immediately before and after treatments, and during the 14 days post- race...
March 7, 2018: Research in Sports Medicine
Carlos Cobo-Vázquez, Gemma De Blas, Pablo García-Canas, María Del Carmen Gasco-García
Cardiopulmonary resuscitation requires the provider to adopt positions that could be dangerous for his or her spine, specifically affecting the muscles and ligaments in the lumbar zone and the scapular spinal muscles. Increased fatigue caused by muscular activity during the resuscitation could produce a loss of quality and efficacy, resulting in compromising resuscitation. The aim of this study was to evaluate the maximum time a rescuer can perform uninterrupted chest compressions correctly without muscle fatigue...
2018: Anesthesia Progress
Muhammad Uzair Lodhi, Tahira Sabeen Saleem, Aaron R Kuzel, Dawood Khan, Intekhab Askari Syed, Umar Rahim, Hafiz Imran Iqbal, Mustafa Rahim
Beer potomania, a unique syndrome of hyponatremia, was first reported in 1972. It is described as the excessive intake of alcohol, particularly beer, together with poor dietary solute intake that leads to fatigue, dizziness, and muscular weakness. The low solute content of beer, and suppressive effect of alcohol on proteolysis result in reduced solute delivery to the kidney. The presence of inadequate solute in the kidney eventually causes dilutional hyponatremia secondary to reduced clearance of excess fluid from the body...
December 29, 2017: Curēus
Yasuhiro Hijikata, Masahisa Katsuno, Keisuke Suzuki, Atsushi Hashizume, Amane Araki, Shinichiro Yamada, Tomonori Inagaki, Daisuke Ito, Akihiro Hirakawa, Fumie Kinoshita, Masahiko Gosho, Gen Sobue
BACKGROUND: Although spinal and bulbar muscular atrophy (SBMA) has been classified as a motor neuron disease, several reports have indicated the primary involvement of skeletal muscle in the pathogenesis of this devastating disease. Recent studies reported decreased intramuscular creatine levels in skeletal muscles in both patients with SBMA and transgenic mouse models of SBMA, which appears to contribute to muscle weakness. OBJECTIVE: The present study aimed to examine the efficacy and safety of oral creatine supplementation to improve motor function in patients with SBMA...
March 5, 2018: JMIR Research Protocols
Tomas Maly, Dai Sugimoto, Jana Izovska, Frantisek Zahalka, Lucia Mala
The aim of this study was to determine the effect of muscular strength, strength asymmetries, and fatigue on the speed and accuracy of an instep kick in soccer players. We measured ball velocity (BV) and kicking accuracy (KA) in the preferred (PL) and non-preferred leg (NPL) before (PRE) and after (POST) physical load in the PL. Maximum peak muscle torque of the knee extensors and flexors in the PL and NPL as well as ipsilateral knee flexors and knee extensors ratio (H:Q ratio) for both legs were assessed. BV was significantly decreased in POST physical load (5...
March 5, 2018: International Journal of Sports Medicine
A Notarnicola, I Covelli, G Maccagnano, R Marvulli, L Mastromauro, G Ianieri, S Boodhoo, A Turitto, L Petruzzella, G Farì, F P Bianchi, S Tafuri, B Moretti
The aim of this study is to investigate the effects of extracorporeal shock wave therapy (ESWT) on muscle rheological and functional properties in a population of young athletes. Thirty-two football and basketball players were recruited and randomized into two groups. The athletes underwent three sessions of therapy administered every five days to the thigh muscles. The treatment consisted of ESWT (electromagnetic generator, Energy Flux Density=0.03 mJ/mm2) or a placebo treatment bilaterally on the quadricep and femoral bicep muscles...
January 2018: Journal of Biological Regulators and Homeostatic Agents
Pavithra S Iyer, Lionel O Mavoungou, Flavio Ronzoni, Joanna Zemla, Emanuel Schmid-Siegert, Stefania Antonini, Laurence A Neff, Olivier M Dorchies, Marisa Jaconi, Malgorzata Lekka, Graziella Messina, Nicolas Mermod
Duchenne muscular dystrophy (DMD) is a lethal muscle-wasting disease currently without cure. We investigated the use of the PiggyBac transposon for full-length dystrophin expression in murine mesoangioblast (MABs) progenitor cells. DMD murine MABs were transfected with transposable expression vectors for full-length dystrophin and transplanted intramuscularly or intra-arterially into mdx/SCID mice. Intra-arterial delivery indicated that the MABs could migrate to regenerating muscles to mediate dystrophin expression...
February 2, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Mark De Ste Croix, Abigail Priestley, Rhodri Lloyd, Jon Oliver
PURPOSE: Fatigue negatively alters dynamic knee control, and the functional hamstring/quadriceps ratio (H/QFUNC ) plays an important role in stabilizing the joint. The aim of this study was to investigate the influence of soccer-specific exercise on H/QFUNC in under (U) 13-, U15-, and U17-year-old female soccer players. METHODS: A total of 36 female players performed concentric and eccentric actions of the hamstrings at 60°, 120°, and 180°/s before and after an age group-specific field-based soccer protocol...
February 27, 2018: Pediatric Exercise Science
Eric M Neverman, Kevin Clary
Fracture of the first rib is rare because of the anatomic protection provided by surrounding structures. Osseous fatigue caused by repetitive motion and antagonistic muscular contraction is postulated to contribute to nontraumatic first rib fracture, which is most often described in adolescent athletes in sports that involve repetitive overhead motion of the arm. In this report, we describe a 49-year-old man with an occupation involving repetitive overhead motion at the shoulder who was found to have a nontraumatic first rib fracture...
March 1, 2018: Journal of the American Osteopathic Association
Gaia Giovannelli, Giorgia Giacomazzi, Hanne Grosemans, Maurilio Sampaolesi
Introduction - Limb-girdle muscular dystrophy type 2E (LGMD 2E) is caused by mutations in the β-sarcoglycan gene, which is expressed in skeletal, cardiac and smooth muscle. β-sarcoglycan deficient (Sgcb-null) mice develop severe muscular dystrophy and cardiomyopathy with focal areas of necrosis. Methods - We performed morphological (histological and cellular characterization) and functional (isometric tetanic force and fatigue) analyses in dystrophic mice. Comparisons studies were carried out in 1-month-old (clinical onset of the disease) and 7-month-old mice among controls (C57/BL6, Rag2/γc-null), immunocompetent and immunodeficient dystrophic mice (Sgcb-null, Sgcb/Rag2/γc-null mice respectively)...
February 24, 2018: Muscle & Nerve
Farouk Chrif, Tobias Nef, Kenneth J Hunt
Background: Leg-press machines are widely employed for musculoskeletal conditioning of the lower-limbs and they provide cardiovascular benefits for resistance training in cardiac patients. The aim of this study was to assess the feasibility of a dynamic leg press (DLP) for incremental cardiopulmonary exercise testing (CPET) and to compare the results with those obtained using a cycle ergometer (CE). Methods: Twelve healthy participants aged 27±4 years (mean ± standard deviation) performed incremental cardiopulmonary exercise tests on a DLP and on a CE...
2018: BMC Sports Science, Medicine and Rehabilitation
Daniela Kühn, Martin Ptok, Michael Jungheim
OBJECTIVE: In about one-third of brass instrumentalists, there are stress-related insufficiencies of velopharyngeal closure (VPC), i. e. the intraoral pressure exceeds the barrier formed by the VPC. Here, it was the aim to measure the VPC closing pressure while playing a trumpet and to evaluate the influence of a 30 minute stress sequence on the muscular activities in the VPC. MATERIAL AND METHODS: Sample: 6 healthy volunteers; task: to play the sound h1 for 5 seconds with 85 dB(A) and with 100 dB(A)...
February 20, 2018: Laryngo- Rhino- Otologie
Akmer Mutlu, Halil Alkan, Tuzun Fırat, Aynur A Karaduman, Oznur T Yilmaz
OBJECTIVE: To compare the fatigue levels and energy expenditure of children with Duchenne Muscular Dystrophy (DMD) at different functional levels with healthy children. METHODS: The cross-sectional study was carried out in the Unit of Pediatric Neuromuscular Diseases in the Department of Physiotherapy and Rehabilitation, Faculty of Health Science, Hacettepe University between March 2015 and January 2016. Fifty two children diagnosed with DMD in Level I-III according to the Brooke Functional Classification Scale and 17 healthy children were included in the study...
January 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Jozo Grgic, Jan Homolak, Pavle Mikulic, Javier Botella, Brad J Schoenfeld
An emerging body of evidence is starting to suggest that the hypertrophy of skeletal muscle fibers might be load specific. In other words, it may be that resistance training with high loads (i.e., ≥60% of 1 repetition maximum [RM]) emphasizes a greater growth of type II muscle fibers, while resistance training with low loads (i.e., <60% of 1RM) might primarily augment hypertrophy of type I muscle fibers. Type I and type II muscle fibers possess certain distinct characteristics, with type II muscle fibers having faster calcium kinetics, faster shortening velocities, and ability to generate more power than type I muscle fibers...
March 2018: Medical Hypotheses
Sylvain Gaudet, Jonathan Tremblay, Fabien Dal Maso
To this day, how shoulder muscles react to a strong fatigue stimulus during dynamic shoulder rotations remains unknown. The aims of this study were to assess the effect of repeated maximal internal-external isokinetic shoulder rotations on shoulder strength and muscle activity. Twenty-four individuals completed a 50-repetition fatiguing isokinetic protocol while electromyography was recorded on eleven muscles of the shoulder girdle. Time-frequency transformation and an ANOVA model using statistical parametric mapping methods were used to analyze shifts in instantaneous median frequency (MDF) between each 10-repetition Blocks...
February 15, 2018: Journal of Sports Sciences
Dimitrios A Patikas, Craig A Williams, Sébastien Ratel
PURPOSE: In recent decades, the interest for exercise-induced fatigue in youth has substantially increased, and the effects of growth on the peripheral (muscular) and central (neural) mechanisms underpinning differences in neuromuscular fatigue between healthy children and adults have been described more extensively. The purpose of this review is to retrieve, report, and analyse the findings of studies comparing neuromuscular fatigue between children and adults. Objective measures of the evaluation of the physiological mechanisms are discussed...
February 13, 2018: European Journal of Applied Physiology
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