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Muscular fatigue

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https://www.readbyqxmd.com/read/27908613/sparc-interacts-with-actin-in-skeletal-muscle-in%C3%A2-vitro-and-in%C3%A2-vivo
#1
Louise H Jørgensen, Pia Lørup Jepsen, Anders Boysen, Line B Dalgaard, Lars G Hvid, Niels Ørtenblad, Dea Ravn, Jeeva Sellathurai, Jakob Møller-Jensen, Hanns Lochmüller, Henrik D Schrøder
The cytoskeleton is an integral part of skeletal muscle structure, and reorganization of the cytoskeleton occurs during various modes of remodeling. We previously found that the extracellular matrix protein secreted protein acidic and rich in cysteine (SPARC) is up-regulated and expressed intracellularly in developing muscle, during regeneration and in myopathies, which together suggests that SPARC might serve a specific role within muscle cells. Using co-immunoprecipitation combined with mass spectrometry and verified by staining for direct protein-protein interaction, we find that SPARC binds to actin...
November 28, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27905901/presynaptic-neuromuscular-transmission-defect-in-the-stiff-person-syndrome
#2
Y L Lo, Y E Tan
BACKGROUND: The stiff person syndrome (SPS) is a rare disorder characterized by muscular rigidity and stiffness. CASE PRESENTATIONS: We describe an SPS patient presenting with longstanding fatigue and electrophysiological evidence of presynaptic neuromuscular transmission defect, who responded to administration of pyridostigmine. In contrast, no electrophysiolgical evidence of neuromuscular transmission defect was demonstrated in 2 other SPS patients without fatigue symptoms...
December 1, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27896952/muscle-strength-in-breast-cancer-patients-receiving-different-treatment-regimes
#3
Oliver Klassen, Martina E Schmidt, Cornelia M Ulrich, Andreas Schneeweiss, Karin Potthoff, Karen Steindorf, Joachim Wiskemann
BACKGROUND: Muscle dysfunction and sarcopenia have been associated with poor performance status, an increased mortality risk, and greater side effects in oncologic patients. However, little is known about how performance is affected by cancer therapy. We investigated muscle strength in breast cancer patients in different adjuvant treatment settings and also compared it with data from healthy individuals. METHODS: Breast cancer patients (N = 255) from two randomized controlled exercise trials, staged 0-III and aged 54...
November 28, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27893858/reversing-age-related-changes-of-the-laryngeal-muscles-by-chronic-electrostimulation-of-the-recurrent-laryngeal-nerve
#4
Michael Karbiener, Jonathan C Jarvis, Justin D Perkins, Hermann Lanmüller, Martin Schmoll, Hanna S Rode, Claus Gerstenberger, Markus Gugatschka
Age related atrophy of the laryngeal muscles -mainly the thyroarytenoid muscle (TAM)- leads to a glottal gap and consequently to a hoarse and dysphonic voice that significantly affects quality of life. The aim of our study was to reverse this atrophy by inducing muscular hypertrophy by unilateral functional electrical stimulation (FES) of the recurrent laryngeal nerve (RLN) in a large animal model using aged sheep (n = 5). Suitable stimulation parameters were determined by fatiguing experiments of the thyroarytenoid muscle in an acute trial...
2016: PloS One
https://www.readbyqxmd.com/read/27867375/ceftriaxone-pulse-dosing-fails-to-eradicate-biofilm-like-microcolony-b-burgdorferi-persisters-which-are-sterilized-by-daptomycin-doxycycline-cefuroxime-without-pulse-dosing
#5
Jie Feng, Shuo Zhang, Wanliang Shi, Ying Zhang
Although the majority of Lyme disease patients can be cured, at least 10-20% of the patients continue to suffer from persisting symptoms such as fatigue, muscular and joint pain, and neurologic impairment after standard 2-4 week antibiotic treatment. While the causes for this post-treatment Lyme disease symptoms are unclear, one possibility is due to Borrelia burgdorferi persisters that are not effectively killed by current antibiotics such as doxycycline or amoxicillin used to treat Lyme disease. A previous study showed that four rounds of ceftriaxone pulse dosing treatment eradicated B...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27863443/gait-assessment-with-solesound-instrumented-footwear-in-spinal-muscular-atrophy
#6
Jacqueline Montes, Damiano Zanotto, Sally Dunaway Young, Rachel Salazar, Darryl C De Vivo, Sunil Agrawal
BACKGROUND: Gait impairment is common in spinal muscular atrophy (SMA) and is described using clinical assessments and instrumented walkways. Continuous over-ground walking has not been studied. METHODS: Nine SMA participants completed the six-minute walk test (6MWT) and 10-meter walk/run wearing instrumented footwear (SoleSound). Data were simultaneously collected using a reference system (GAITRite(TM) ). The root mean square error (RMSE) indicated criterion validity...
November 18, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27857248/physical-and-psychological-effects-of-a-12-session-cancer-rehabilitation-exercise-program
#7
Tricia M Smith, Christine N Broomhall, Anne R Crecelius
BACKGROUND: The positive effects of regular exercise for cancer survivors are becoming increasingly apparent. However, comprehensive examination of the benefits of modest levels of physical activity is somewhat lacking. OBJECTIVES: This study aimed to test the hypothesis that participating in a 12-session exercise program will improve depression, fatigue, aerobic endurance, muscular strength, and quality of life (QOL) in patients with cancer. METHODS: A group of 20 older adult women with a prior cancer diagnosis were evaluated during a 6- to 10-week exercise program that occurred twice weekly...
December 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27856712/rates-of-performance-loss-and-neuromuscular-activity-in-men-and-women-during-cycling-evidence-for-a-common-metabolic-basis-of-muscle-fatigue
#8
Christopher W Sundberg, Sandra K Hunter, Matthew W Bundle
The durations that muscular force and power outputs can be sustained until failure fall predictably on an exponential decline between an individual's 3-s burst maximum to the maximum performance they can sustain aerobically. The exponential time constants describing these rates of performance loss are similar across individuals suggesting that a common metabolically-based mechanism governs muscle fatigue; however, these conclusions come from studies mainly on men. To test whether the same physiological understanding can be applied to women, we compared the performance-duration relationships and neuromuscular activity between 7 men (23...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27845667/walking-with-a-backpack-using-load-distribution-and-dynamic-load-compensation-reduces-metabolic-cost-and-adaptations-to-loads
#9
Joon-Hyuk Park, Paul Stegall, Haohan Zhang, Sunil Agrawal
In this study, we showed a way of reducing the metabolic cost of walking with a backpack using load distribution and dynamic load compensation, provided by a wearable upper body device. This device distributes the backpack load between the shoulders and the pelvis, senses the vertical motion of the pelvis, and provides gait synchronized compensatory forces to reduce the dynamic loads from a backpack. It was hypothesized that by reducing dynamic loads from a backpack during load carriage, the users gait and postural adaptation, muscular effort and metabolic cost would be reduced...
November 9, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27830144/strength-training-improves-fatigue-resistance-and-self-rated-health-in-workers-with-chronic-pain-a-randomized-controlled-trial
#10
Emil Sundstrup, Markus Due Jakobsen, Mikkel Brandt, Kenneth Jay, Per Aagaard, Lars Louis Andersen
Chronic musculoskeletal pain is widespread in the working population and leads to muscular fatigue, reduced work capacity, and fear of movement. While ergonomic intervention is the traditional approach to the problem, physical exercise may be an alternative strategy. This secondary analysis of a randomized controlled trial investigates the effect of strength training on muscular fatigue resistance and self-rated health among workers with chronic pain. Sixty-six slaughterhouse workers with chronic upper limb pain and work disability were randomly allocated to 10 weeks of strength training or usual care ergonomic training (control)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27826760/myotonic-dystrophy-type-1-management-and-therapeutics
#11
REVIEW
Cheryl A Smith, Laurie Gutmann
Myotonic dystrophy (DM1) is the most common form of adult muscular dystrophy. It is a multisystem disorder with a complex pathophysiology. Although inheritance is autosomal dominant, disease variability is attributed to anticipation, a maternal expansion bias, variable penetrance, somatic mosaicism, and a multitude of aberrant pre-mRNA splicing events. Patient presentations range from asymptomatic or mild late onset adult to severe congenital forms. Multiple organ systems may be affected. Patients may experience early cataracts, myotonia, muscle weakness/atrophy, fatigue, excessive daytime sleepiness, central/obstructive apnea, respiratory failure, cardiac arrhythmia, insulin resistance, dysphagia, GI dysmotility, cognitive impairment, Cluster C personality traits, and/or mood disorders...
December 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27824235/radial-shock-wave-therapy-effect-on-pain-and-motor-performance-in-a-paralympic-athlete-a-case-report
#12
Laura Mori, Lucio Marinelli, Elisa Pelosin, Matteo Gambaro, Roberto Trentini, Giovanni Abbruzzese, Carlo Trompetto
BACKGROUND: Recent studies demonstrated the usefulness of Radial Shock Waves Therapy (RSWT) in treating hypertonia in patients affected by cerebral palsy (CP), stroke, and dystonia. RSWT have never been used to treat spasticity in disabled athletes. CASE REPORT: An athlete affected by tetraparesis due to CP underwent three RSWT sessions in a week. We assessed muscular tone using the Modified Ashworth scale (MAS), pain and fatigue experienced during athletic performance with Visual Analogic Scale (VAS) and Borg scale Category-Ratio anchored at number 10 (Borg CR10)...
November 8, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27798634/influence-of-fatigue-on-tackling-ability-in-rugby-league-players-role-of-muscular-strength-endurance-and-aerobic-qualities
#13
Tim J Gabbett
This study investigated the influence of repeated high-intensity effort exercise on tackling ability in rugby league players, and determined the relationship between physical qualities and tackling ability under fatigued conditions in these athletes. Eleven semi-professional rugby league players underwent measurements of speed (10 m and 40 m sprint), upper-body strength (4 repetition maximum [RM] bench press and weighted chin-up), upper-body muscular endurance (body mass maximum repetition chin-up, body mass maximum repetition dips), lower-body strength (4RM squat), and estimated maximal aerobic power (multi-stage fitness test)...
2016: PloS One
https://www.readbyqxmd.com/read/27798107/high-levels-of-sarcospan-are-well-tolerated-and-act-as-a-sarcolemmal-stabilizer-to-address-skeletal-muscle-and-pulmonary-dysfunction-in-dmd
#14
Elizabeth M Gibbs, Jamie L Marshall, Eva Ma, Thien M Nguyen, Grace Hong, Jessica Lam, Melissa J Spencer, Rachelle H Crosbie-Watson
Duchenne muscular dystrophy (DMD) is a genetic disorder that causes progressive muscle weakness, ultimately leading to early mortality in affected teenagers and young adults. Previous work from our lab has shown that a small transmembrane protein called sarcospan (SSPN) can enhance the recruitment of adhesion complex proteins to the cell surface. When human SSPN is expressed at three-fold levels in mdx mice, this increase in adhesion complex abundance improves muscle membrane stability, preventing many of the histopathological changes associated with DMD...
October 24, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27762634/fatigue-in-facioscapulohumeral-muscular-dystrophy-a-qualitative-study-of-people-s-experiences
#15
Karen Schipper, Minne Bakker, Tineke Abma
PURPOSE: The aim of this article is to describe how fatigue affects the lives of people with facioscapulohumeral dystrophy (FSHD), how they experience fatigue, and how they deal with it in order to attune rehabilitation care to patients' needs. METHOD: A qualitative study, consisting of 25 semistructured interviews with patients with FSHD and severe fatigue (as measured with the checklist individual strength (CIS) fatigue questionnaire), was conducted to gain insight into the experiences of patients with fatigue...
October 20, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27759888/dysphagia-related-quality-of-life-in-oculopharyngeal-muscular-dystrophy-psychometric-properties-of-the-swal-qol-instrument
#16
Sarah Youssof, Carol Romero-Clark, Teddy Warner, Emily Plowman
INTRODUCTION: The Swallowing Quality of Life instrument (SWAL-QOL) is a patient-reported outcome (PRO) measure of swallowing-related quality of life (SR-QoL). Its psychometric properties in oculopharyngeal muscular dystrophy (OPMD) are not known. METHODS: We administered the SWAL-QOL to U.S. OPMD Registry participants. We described SR-QoL profiles and assessed reliability and validity. RESULTS: Mean composite score in 113 individuals with OPMD was 54...
October 19, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27747926/fitness-and-its-association-with-fatigue-in-persons-with-multiple-sclerosis
#17
E Sebastião, E A Hubbard, R E Klaren, L A Pilutti, R W Motl
This study compared physical fitness components between fatigued and non-fatigued persons with MS and examined those components as correlates of fatigue. Sixty-two ambulatory persons with MS completed the Modified Fatigue Impact Scale (MFIS) and underwent assessments of cardiorespiratory capacity, lower extremity muscle strength (i.e., peak torque and asymmetry), body composition, and static balance over two different sessions 7 days apart. Participants were allocated into fatigue groups based on MFIS scores (non-fatigued group (i...
October 17, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27743011/variability-in-spatio-temporal-pattern-of-trapezius-activity-and-coordination-of-hand-arm-muscles-during-a-sustained-repetitive-dynamic-task
#18
Afshin Samani, Divya Srinivasan, Svend Erik Mathiassen, Pascal Madeleine
The spatio-temporal distribution of muscle activity has been suggested to be a determinant of fatigue development. Pursuing this hypothesis, we investigated the pattern of muscular activity in the shoulder and arm during a repetitive dynamic task performed until participants' rating of perceived exertion reached 8 on Borg's CR-10 scale. We collected high-density surface electromyogram (HD-EMG) over the upper trapezius, as well as bipolar EMG from biceps brachii, triceps brachii, deltoideus anterior, serratus anterior, upper and lower trapezius from 21 healthy women...
October 14, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27740597/lactate-as-a-signaling-molecule-that-regulates-exercise-induced-adaptations
#19
Minas Nalbandian, Masaki Takeda
Lactate (or its protonated form: lactic acid) has been studied by many exercise scientists. The lactate paradigm has been in constant change since lactate was first discovered in 1780. For many years, it was unfairly seen as primarily responsible for muscular fatigue during exercise and a waste product of glycolysis. The status of lactate has slowly changed to an energy source, and in the last two decades new evidence suggests that lactate may play a much bigger role than was previously believed: many adaptations to exercise may be mediated in some way by lactate...
October 8, 2016: Biology
https://www.readbyqxmd.com/read/27736246/the-effect-of-green-tea-and-sour-tea-hibiscus-sabdariffa-l-supplementation-on-oxidative-stress-and-muscle-damage-in-athletes
#20
Amir Hadi, Makan Pourmasoumi, Marzieh Kafeshani, Jahangir Karimian, Mohammad Reza Maracy, Mohammad Hasan Entezari
OBJECTIVE: Additional oxygen consumption during intense exercises may lead to oxidative stress and contribute to muscular fatigue. Green tea and sour tea (Hibiscus sabdariffa L.), which contain various flavonoids and polyphenols, have many healthful properties such as anticarcinogenic, anti-inflammatory, and heart protecting effects. The aim of the present study was to assess the effects of green tea and sour tea supplementation on oxidative stress and muscle damage in soccer athletes...
October 13, 2016: Journal of Dietary Supplements
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