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Cirrhosis imaging

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https://www.readbyqxmd.com/read/28918191/development-and-validation-of-a-chronic-pancreatitis-prognosis-score-in-2-independent-cohorts
#1
Georg Beyer, Ujjwal M Mahajan, Christoph Budde, Thomas J Bulla, Thomas Kohlmann, Louise Kuhlmann, Kerstin Schütte, Ali A Aghdassi, Eckhard Weber, Ulrich Weiss, Asbjørn M Drewes, Søren S Olesen, Markus M Lerch, Julia Mayerle
BACKGROUND & AIMS: The clinical course of chronic pancreatitis is unpredictable. There is no model to assess disease severity or progression or predict patient outcomes. METHODS: We performed a prospective study of 91 patients with chronic pancreatitis; data were collected from patients seen at academic centers in Europe, from January 2011 through April 2014. We analyzed correlations between clinical, laboratory, and imaging data with number of hospital readmissions and in-hospital days over the next 12 months; the parameters with the highest degree of correlation were to develop 3-stage chronic pancreatitis prognosis score (COPPS)...
September 14, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28915639/heptamethine-carbocyanine-dz-1-dye-for-near-infrared-fluorescence-imaging-of-hepatocellular-carcinoma
#2
Jiaze An, Ningning Zhao, Caiqin Zhang, Yong Zhao, Dengxu Tan, Ya Zhao, Bing Bai, Hai Zhang, Boyang Jason Wu, Changhong Shi
Near-infrared fluorescence (NIRF) dyes have recently emerged as promising tools for non-invasive imaging of different types of cancers. Here, we explored the potential utility of a NIRF DZ-1 dye, with dual imaging and tumour targeting functions, in hepatocellular carcinoma (HCC). We showed the preferential uptake of DZ-1 by HCC cells in vitro and in derived subcutaneous/orthotopic tumour xenografts, accompanied by a minimal effect on normal cells. DZ-1 simplified tumour growth profiling as well, since we were able to correlate NIRF signals with tumour volume and/or tumour-emitting luminescence in mice...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28905413/simultaneous-acquisition-sequence-for-improved-hepatic-pharmacokinetics-quantification-accuracy-saha-for-dynamic-contrast-enhanced-mri-of-liver
#3
Jia Ning, Yongliang Sun, Sheng Xie, Bida Zhang, Feng Huang, Peter Koken, Jouke Smink, Chun Yuan, Huijun Chen
PURPOSE: To propose a simultaneous acquisition sequence for improved hepatic pharmacokinetics quantification accuracy (SAHA) method for liver dynamic contrast-enhanced MRI. METHODS: The proposed SAHA simultaneously acquired high temporal-resolution 2D images for vascular input function extraction using Cartesian sampling and 3D large-coverage high spatial-resolution liver dynamic contrast-enhanced images using golden angle stack-of-stars acquisition in an interleaved way...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28903414/micro-hccs-in-rats-with-liver-cirrhosis-paradoxical-targeting-effects-with-vascular-disrupting-agent-ca4p
#4
Yewei Liu, Ting Yin, Frederik De Keyzer, Yuanbo Feng, Feng Chen, Jianjun Liu, Shaoli Song, Jie Yu, Vincent Vandecaveye, Johan Swinnen, Guy Bormans, Uwe Himmelreich, Raymond Oyen, Jian Zhang, Gang Huang, Yicheng Ni
We sought to investigate anticancer efficacy of a vascular disrupting agent (VDA) combretastatin A-4 phosphate (CA4P) in relation to tumor size among hepatocellular carcinomas (HCCs) in rats using magnetic resonance imaging (MRI) and postmortem techniques. Nineteen rats with 43 chemically-induced HCCs of 2.8-20.9 mm in size on liver cirrhosis received CA4P intravenously at 10 mg/kg. Tumor-diameter was measured by T2-weighted imaging (T2WI) to define microcancers (< 5 mm) versus larger HCCs. Vascular responses and tissue necrosis were detected by diffusion-weighted imaging (DWI), contrast-enhanced T1-weighted imaging (CE-T1WI) and dynamic contrast enhanced (DCE-) MRI, which were validated by microangiography and histopathology...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900996/-clinicopathologic-characteristics-and-prognosis-of-gastric-hepatoid-adenocarcinoma
#5
Rongfei Zhao, Xinxin Wang, Xin Lan, Mingsen Li
OBJECTIVE: To investigate the clinicopathological characteristics, diagnosis, treatment and prognosis of gastric hepatoid adenocarcinoma(HAS). METHODS: Retrospective analysis of clinicopathological data of 24 cases with gastric HAS diagnosed by surgery and pathology in Chinese PLA General Hospital from January 2013 to May 2016 were carried out. All the patients underwent preoperative serum alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), endoscopy and imaging examination (CT or B-mode ultrasonography), and those with elevated AFP were excluded from liver cancer, cirrhosis, endodermal sinus tumor and other diseases...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28898796/transjugular-biopsy-case-report-of-inferior-vena-cava-hepatocellular-carcinoma-with-intracardiac-extension
#6
Laurence Weinberg, Diana Abu-Ssaydeh, Chris Macgregor, Jason Wang, Clarence Wong, Manfred Spanger, Vijayragavan Muralidharan
BACKGROUND: Diagnosis of hepatocellular carcinoma (HCC) can be established with near certainty by correlating radiological imaging with clinical presentation. However, in the absence of diagnostic certainty, biopsy of liver tissue is mandatory for optimal management. We present our management of a patient with advanced liver disease who presented with an IVC mass extending into the right atrium, with co-existing liver lesions not meeting criteria for an imaging diagnosis of HCC. CASE PRESENTATION: A 62-year-old male with Child-Pugh C liver cirrhosis presented with decompensated liver failure...
September 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28894901/imaging-features-of-microvascular-invasion-in-hepatocellular-carcinoma-developed-after-direct-acting-antiviral-therapy-in-hcv-related-cirrhosis
#7
Matteo Renzulli, Federica Buonfiglioli, Fabio Conti, Stefano Brocchi, Ilaria Serio, Francesco Giuseppe Foschi, Paolo Caraceni, Giuseppe Mazzella, Gabriella Verucchi, Rita Golfieri, Pietro Andreone, Stefano Brillanti
OBJECTIVES: To evaluate imaging features of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) developed after direct-acting antiviral (DAA) therapy in HCV-related cirrhosis. METHODS: Retrospective cohort study on 344 consecutive patients with HCV-related cirrhosis treated with DAA and followed for 48-74 weeks. Using established imaging criteria for MVI, HCC features were analysed and compared with those in nodules not occurring after DAA. RESULTS: After DAA, HCC developed in 29 patients (single nodule, 18 and multinodular, 11)...
September 11, 2017: European Radiology
https://www.readbyqxmd.com/read/28893408/inflammatory-myopathy-associated-with-antimitochondrial-antibodies-a-distinct-phenotype-with-cardiac-involvement
#8
Jemima Albayda, Aamna Khan, Livia Casciola-Rosen, Andrea M Corse, Julie J Paik, Lisa Christopher-Stine
OBJECTIVE: In the context of clinical evaluations performed on our prospective myositis cohort, we noted a striking association of severe cardiac disease in myositis patients with antimitochondrial antibodies. We sought to review all cases of antimitochondrial antibody (AMA) associated myositis in our cohort to describe the clinical features of this disease subset. METHODS: We identified 7 patients with confirmed antimitochondrial antibodies who presented as an inflammatory myopathy...
June 13, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28892997/quantification-of-liver-fat-with-mdixon-magnetic-resonance-imaging-comparison-with-the-computed-tomography-and-the-biopsy
#9
Venkatraman Bhat, Sundararaman Velandai, Vikram Belliappa, Jeyeram Illayraja, Karthik Gadabana Halli, Gayathri Gopalakrishnan
INTRODUCTION: Accurate, non-invasive method of fat estimation is a valuable test for evaluation of diseases with abnormal hepatic fat. AIM: To determine the accuracy of mDixon MR technique in assessment of liver fat over CT and to correlate the CT and MRI findings with biopsy. MATERIALS AND METHODS: A prospective observational study was conducted at Imaging Services of Narayana Multispeciality Hospital between March 2011- December 2012. Thirty patients who attended the clinic for non-hepatic complaints were included in the study...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28880053/liver-fibrosis-the-2017-state-of-art
#10
Gian P Caviglia, Chiara Rosso, Sharmila Fagoonee, Giorgio M Saracco, Rinaldo Pellicano
Liver fibrosis is a wound-healing response to a wide spectrum of chronic liver injuries. It is characterized by loss of hepatocytes and alteration in hepatic architecture following an imbalance between extracellular matrix synthesis and degradation. Irrespectively of underlying etiology, fibrosis may progress to cirrhosis and specific pathogenetic mechanisms as well as different disease patterns may be identified according to etiology. Liver biopsy is still considered the gold standard for fibrosis assessment, despite the fact that it is invasive, has poor patient compliance and is not exempt of complications...
September 5, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28879656/variability-in-responses-observed-in-human-white-adipose-tissue-models
#11
Rosalyn D Abbott, Francis E Borowsky, Carlo A Alonzo, Adam Zieba, Irene Georgakoudi, David L Kaplan
Obesity is a risk factor for a myriad of diseases including diabetes, cardiovascular dysfunction, cirrhosis and cancer and there is a need for new systems to study how excess adipose tissue relates to the onset of disease processes. This study provides proof of concept patient-specific tissue models of human white adipose tissue to accommodate the variability in human samples. Our 3D tissue engineering approach established lipolytic responses and changes in insulin-stimulated glucose uptake from small volumes of human lipoaspirate, making this methodology useful for patient specific sample source assessments of treatment strategies, drug responses, disease mechanisms and other responses that vary between patients...
September 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28872150/clinical-characteristics-and-outcome-of-hepatic-sarcoidosis-a-population-based-study-1976-2013
#12
Patompong Ungprasert, Cynthia S Crowson, Douglas A Simonetto, Eric L Matteson
OBJECTIVES: Data on clinical manifestations and outcome of hepatic sarcoidosis are scarce. This study aimed to use a population-based cohort of patients with incident sarcoidosis to better describe the characteristics of hepatic sarcoidosis. METHODS: A cohort of incident cases of sarcoidosis in Olmsted County, MN, USA, from 1976 to 2013 was identified from the database. Diagnosis was verified by individual medical record review. Confirmed cases of sarcoidosis were then reviewed for liver involvement...
September 5, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28870485/low-skeletal-muscle-mass-predicts-early-mortality-in-cirrhotic-patients-with-acute-variceal-bleeding
#13
Yoji Ishizu, Masatoshi Ishigami, Teiji Kuzuya, Takashi Honda, Kazuhiko Hayashi, Tetsuya Ishikawa, Yoshiki Hirooka, Hidemi Goto
OBJECTIVES: Low skeletal muscle mass adversely affects outcomes in cirrhotic patients; however, its affect in patients with acute variceal bleeding remains unknown. The aim of this study was to evaluate the effects of low skeletal muscle mass on outcomes in patients with cirrhosis and acute variceal bleeding. METHODS: We evaluated 122 patients to identify factors associated with two outcomes: failure to control bleeding, defined as either rebleeding or death within 5 d, and 6-wk mortality...
October 2017: Nutrition
https://www.readbyqxmd.com/read/28863782/effectiveness-of-pivka-ii-in-the-detection-of-hepatocellular-carcinoma-based-on-real-world-clinical-data
#14
Rentao Yu, Zhaoxia Tan, Xiaomei Xiang, Yunjie Dan, Guohong Deng
BACKGROUND: Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) is an efficient biomarker specific for hepatocellular carcinoma (HCC). Some researchers have proved that levels of PIVKA-II reflect HCC oncogenesis and progression. However, the effectiveness of PIVKA-II based on real-world clnical data has barely been studied. METHODS: A total of 14,861 samples were tested in Southwest Hospital in over 2 years' time. Among them, 4073 samples were PIVKA-II positive...
September 1, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28859233/imaging-for-the-diagnosis-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#15
REVIEW
Lewis R Roberts, Claude B Sirlin, Feras Zaiem, Jehad Almasri, Larry J Prokop, Julie Heimbach, M Hassan Murad, Khaled Mohammed
Multiphasic computed tomography (CT) and magnetic resonance imaging (MRI) are both used for non-invasive diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis. To determine if there is a relative diagnostic benefit of one over the other, we synthesized evidence regarding the relative performances of CT, extracellular-contrast-enhanced-MRI, and gadoxetate-enhanced-MRI for diagnosis of HCC in patients with cirrhosis. We also assessed whether liver biopsy versus follow-up with the same versus alternative imaging is best for CT- or MRI-indeterminate liver nodules in patients with cirrhosis...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28858943/increased-risk-of-mortality-associated-with-pancreatic-exocrine-insufficiency-in-patients-with-chronic-pancreatitis
#16
Daniel de la Iglesia-Garcia, Nicolau Vallejo-Senra, Julio Iglesias-Garcia, Andrea López-López, Laura Nieto, J Enrique Domínguez-Muñoz
BACKGROUND: Pancreatic exocrine insufficiency (PEI) is a common serious complication in chronic pancreatitis (CP); however, little is known about its effect on mortality in these patients. In this study, we assessed the mortality risk of PEI in patients with CP. STUDY: A prospective, longitudinal cohort study conducted in patients with CP under long-term follow-up. CP and PEI were diagnosed using pancreatic imaging and the C-labeled mixed triglyceride breath test, respectively...
August 30, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28853803/-portal-vein-thrombosis-in-patients-with-cirrhosis
#17
Melissa Dupuis, Laurent Spahr, Emiliano Giostra, Laure Elkrief
Portal vein thrombosis is frequently encountered in patients with cirrhosis. Increased indication for non-invasive imaging in patients with cirrhosis has dramatically increased the recognition of PVT. This has led to a large amount of studies on pathogenesis as well as the prognostic impact of portal vein thrombosis on natural history of cirrhosis. However, in clinical practice, several aspects of the management of portal vein thrombosis remain unclear. This practical review discusses the most recent data toward the management of portal vein thrombosis in cirrhosis, especially regarding : a) the value of etiological workup ; b) the impact of portal vein thrombosis on the natural history of cirrhosis, and c) the indications and modalities of anticoagulation therapy...
August 30, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28844927/skull-metastasis-from-the-liver-case-report-and-literature-review
#18
Shuo Han, Xiao-Hua Zhang, Tao Lv, Dong-Hua Han
BACKGROUND: Calvarial metastasis from liver cirrhosis in the absence of a primary focus is exceptionally rare. Few reports of metastases from hepatocellular carcinoma of an unknown primary focus have been published. CASE DESCRIPTION: A 66-year old male with a history of Schistosoma japonicum infection presented to our hospital with a mass over the left occipital region, associated with headache and dizziness. Imaging revealed a 6x5cm lesion supplied principally by the left occipital artery...
August 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28844464/non-invasive-assessment-of-liver-fibrosis-with-elastpq-comparison-with-transient-elastography-and-serologic-fibrosis-marker-tests-and-correlation-with-liver-pathology-results
#19
Jeong Eun Lee, Kyung Sook Shin, June-Sik Cho, Sun Kyoung You, Ji Hye Min, Kyung-Hee Kim, In Sang Song, Kwang Sik Cheon
We investigated the feasibility of using ultrasound shear wave elastography point quantification (ElastPQ) for liver fibrosis staging and compared it with other non-invasive tools with respect to efficacy in liver stiffness measurement. A total of 106 patients who underwent liver stiffness measurements, using ElastPQ and biochemical investigations, before parenchymal liver biopsy or surgery were included. Among these, 51 also underwent transient elastography (TE). Correlations of ElastPQ, TE and aspartate aminotransferase-to-platelet ratio index (APRI) with histopathological findings (as the reference standard) were determined using Spearman's correlation coefficient...
August 24, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28843273/fusion-anomaly-of-the-pancreatic-tail-and-spleen-a-case-report
#20
Ahmad Khalid Omeri, Shunro Matsumoto, Maki Kiyonaga, Ryo Takaji, Yasunari Yamada, Yumiko Ando, Hiromu Mori, Hiroki Uchida, Yukio Iwashita, Masayuki Ohta, Masafumi Inomata
BACKGROUND: Splenopancreatic fusion is a rare anomaly that is often associated with trisomy 13. Its diagnosis can be important in patients scheduled to undergo distal pancreatectomy or splenectomy, to avoid possible intraoperative or postoperative complications. CASE PRESENTATION: An 82-year-old Japanese man was referred to our hospital for further evaluation and treatment for a solitary hepatocellular carcinoma based on liver cirrhosis. Triple-phase contrast-enhanced multidetector-row computed tomography and magnetic resonance imaging showed a splenopancreatic fusion as well as a solitary hepatocellular carcinoma in segment VIII of his liver...
August 27, 2017: Journal of Medical Case Reports
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