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Qualitative secondary analysis

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https://www.readbyqxmd.com/read/28079756/optical-coherence-tomography-angiography-changes-in-early-type-3-neovascularization-after-anti-vascular-endothelial-growth-factor-treatment
#1
Alexandra Miere, Giuseppe Querques, Oudy Semoun, Francesca Amoroso, Olivia Zambrowski, Thibaut Chapron, Vittorio Capuano, Eric H Souied
PURPOSE: To investigate the morphologic changes on optical coherence tomography angiography (OCTA) of treatment-naive Type 3 neovascularization secondary to exudative age-related macular degeneration after 1 year of anti-vascular endothelial growth factor therapy. METHODS: Consecutive patients diagnosed with treatment-naive early-stage Type 3 neovascularization were enrolled in this retrospective study. All patients underwent color fundus photographs/MultiColor (Heidelberg Engineering) imaging, fluorescein angiography, indocyanine green angiography, structural spectral domain OCT, and OCTA Optovue RTVue XR Avanti (Optovue) at baseline, and repeated OCTA and structural spectral domain OCT at Month 12...
January 10, 2017: Retina
https://www.readbyqxmd.com/read/28076372/bad-to-the-bone-on-in-vitro-and-ex-vivo-microbial-biofilm-ability-to-directly-destroy-colonized-bone-surfaces-without-participation-of-host-immunity-or-osteoclastogenesis
#2
Adam Junka, Patrycja Szymczyk, Grzegorz Ziółkowski, Ewa Karuga-Kuzniewska, Danuta Smutnicka, Iwona Bil-Lula, Marzenna Bartoszewicz, Susan Mahabady, Parish Paymon Sedghizadeh
Bone infections are a significant public health burden associated with morbidity and mortality in patients. Microbial biofilm pathogens are the causative agents in chronic osteomyelitis. Research on the pathogenesis of osteomyelitis has focused on indirect bone destruction by host immune cells and cytokines secondary to microbial insult. Direct bone resorption by biofilm pathogens has not yet been seriously considered. In this study, common osteomyelitis pathogens (Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Streptococcus mutans) were grown as biofilms in multiple in vitro and ex vivo experiments to analyze quantitative and qualitative aspects of bone destruction during infection...
2017: PloS One
https://www.readbyqxmd.com/read/28070254/the-efficacy-of-contingency-management-on-cocaine-craving-using-prize-based-reinforcement-of-abstinence-in-cocaine-users
#3
Bijan Pirnia, Seyed Kazem Rasoulzadeh Tabatabaei, Abbas Tavallaii, Ali Akbar Soleimani, Kambiz Pirnia
INTRODUCTION: Contingency management (CM) is one of the most common therapies in the domain of drug addiction. This study has been carried out with the purpose of evaluating the efficacy of contingency management intervention. METHOD: In an experimental design, between December 15, 2014 and November 20, 2015, fifty men (between 18 and 31 with an average age of 24.6) with a history of cocaine use, were selected voluntarily and were randomly assigned into two groups of CM and control group...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28069990/reframing-inequality-the-health-inequalities-turn-as-a-dangerous-frame-shift
#4
Julia Lynch
BACKGROUND: Politicians in many countries have embraced the notion that health inequalities derive from socioeconomic inequalities, but European governments have for the most part failed to enact policies that would reduce underlying social inequalities. METHODS: Data are drawn from 84 in-depth interviews with policy-makers in four European countries between 2012 and 2015, qualitative content analysis of recent health inequalities policy documents, and secondary literature on the barriers to implementing evidence-based health inequalities policies...
January 9, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28069667/from-loquacious-to-reticent-understanding-patient-health-information-communication-to-guide-consumer-health-it-design
#5
Rupa S Valdez, Thomas M Guterbock, Kara Fitzgibbon, Ishan C Williams, Claire A Wellbeloved-Stone, Jaime E Bears, Hannah K Menefee
BACKGROUND AND SIGNIFICANCE: It is increasingly recognized that some patients self-manage in the context of social networks rather than alone. Consumer health information technology (IT) designed to support socially embedded self-management must be responsive to patients' everyday communication practices. There is an opportunity to improve consumer health IT design by explicating how patients currently leverage social media to support health information communication. OBJECTIVE: The objective of this study was to determine types of health information communication patterns that typify Facebook users with chronic health conditions to guide consumer health IT design...
January 9, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28069416/abnormal-lipid-metabolism-in-skeletal-muscle-tissue-of-patients-with-muscular-dystrophy-in-vitro-high-resolution-nmr-spectroscopy-based-observation-in-early-phase-of-the-disease
#6
Niraj Kumar Srivastava, Ramakant Yadav, Somnath Mukherjee, Lily Pal, Neeraj Sinha
PURPOSE: Qualitative (assignment of lipid components) and quantitative (quantification of lipid components) analysis of lipid components were performed in skeletal muscle tissue of patients with muscular dystrophy in early phase of the disease as compared to control/normal subjects. METHODS: Proton nuclear magnetic resonance (NMR) spectroscopy based experiment was performed on the lipid extract of skeletal muscle tissue of patients with muscular dystrophy in early phase of the disease and normal individuals for the analysis of lipid components [triglycerides, phospholipids, total cholesterol and unsaturated fatty acids (arachidonic, linolenic and linoleic acid)]...
January 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28062603/combining-qualitative-and-quantitative-operational-research-methods-to-inform-quality-improvement-in-pathways-that-span-multiple-settings
#7
Sonya Crowe, Katherine Brown, Jenifer Tregay, Jo Wray, Rachel Knowles, Deborah A Ridout, Catherine Bull, Martin Utley
BACKGROUND: Improving integration and continuity of care across sectors within resource constraints is a priority in many health systems. Qualitative operational research methods of problem structuring have been used to address quality improvement in services involving multiple sectors but not in combination with quantitative operational research methods that enable targeting of interventions according to patient risk. We aimed to combine these methods to augment and inform an improvement initiative concerning infants with congenital heart disease (CHD) whose complex care pathway spans multiple sectors...
January 6, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28057447/antidepressant-prescribing-by-pediatricians-a-mixed-methods-analysis
#8
Anne K Tulisiak, Jillian A Klein, Emily Harris, Marissa J Luft, Heidi K Schroeder, Sarah A Mossman, Sara T Varney, Brooks R Keeshin, Sian Cotton, Jeffrey R Strawn
Among pediatricians, perceived knowledge of efficacy, tolerability, dosing, and side effects of antidepressants represent significant sources of variability in the use of these medications in youth with depressive and anxiety disorders. Importantly, the qualitative factors that relate to varying levels of comfort with antidepressants and willingness to prescribe are poorly understood. Using a mixed-methods approach, in-depth interviews were conducted with community-based and academic medical center-based pediatricians (N = 14)...
January 2, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28053390/effectiveness-of-arthroscopic-elbow-synovectomy-in-rheumatoid-arthritis-patients-long-term-follow-up-of-clinical-and-functional-outcomes
#9
Vivek Shankar, Pankaj Sharma, Ravi Mittal, Samarth Mittal, Uma Kumar, Shivanand Gamanagatti
OBJECTIVE: To determine the long-term clinical and functional results of arthroscopic elbow synovectomy in rheumatoid arthritis patients with refractory elbow synovitis in terms of improvement in pain, function, and active range of motion (AROM) or arc of motion. METHOD: Fifteen rheumatoid elbows in 13 patients, not responding to DMARD therapy and with radiological changes not more than Larsen grade 3 were taken, who underwent arthroscopic elbow synovectomy. The main outcome measured in forms of Mayo Elbow Performance Scale (MEPS) score, measurement of pain using a Visual Analogue Scale (VAS), radiological angles of elbow, disease activity score (DAS-28), arc of motions (AOM) and complications, which were assessed at follow-up periods of 6 months, 24 months, and 30 months...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28050947/-you-just-can-t-trust-everybody-the-impact-of-sexual-risk-partner-type-and-perceived-partner-trustworthiness-on-hiv-status-disclosure-decisions-among-hiv-positive-black-gay-and-bisexual-men
#10
Jason D P Bird, Michael Eversman, Dexter R Voisin
HIV remains an intractable public health concern in the USA, with infection rates notably concentrated among Black gay and bisexual men. Status disclosure by HIV-positive individuals can be an important aspect of risk reduction but doing so poses dilemmas concerning privacy, stigma and self-protection, especially among populations subjected to multiple types of stigmatisation. Understanding the factors related to the disclosure process can help to inform prevention efforts. Using exploratory in-depth interviews, this qualitative study examines the disclosure process among a sample of twenty HIV-positive Black gay and bisexual men (mean age = 40) recruited through a non-profit health centre in a mid-western city in the USA...
January 4, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28044269/under-five-child-mortality-and-morbidity-associated-with-consanguineous-child-marriage-in-pakistan-retrospective-analysis-using-pakistan-demographic-and-health-surveys-1990-91-2006-07-2012-13
#11
Mudasir Mustafa, Rubeena Zakar, Muhammad Zakria Zakar, Ashraf Chaudhry, Muazzam Nasrullah
Objective To assess the combined effect of consanguineous and child marriages (CCM) on children health, which has not previously been explored, either globally or locally. Methods We analyzed secondary data from a series of cross-sectional, nationally representative Pakistan Demographic and Health Surveys 1990-91, 2006-07, and 2012-13. A total of 5406 mothers with 10,164 children were included in the analysis. Child health was assessed by variables such as history of diarrhea, acute respiratory infection (ARI), ARI with fever, Under-5 child mortality (U5CM) and small-size birth (SSB)...
January 2, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28030811/systematic-review-of-resecting-primary-tumor-in-mnets-patients-with-unresectable-liver-metastases
#12
Jingfei Guo, Qian Zhang, Xinyu Bi, Jianguo Zhou, Zhiyu Li, Zhen Huang, Yefan Zhang, Muxing Li, Xiao Chen, Xuhui Hu, Chi Yihebali, Junbo Liang, Jianmei Liu, Jianjun Zhao, Jianqiang Cai, Hong Zhao
BACKGROUND: Treatment for midgut neuroendocrine tumor patients with unresectable liver metastasis has long been a controversial issue. This system review aims to summarize existing evidence concerning the value of primary tumor resection in this group of patients. RESULTS: 8 cohort studies were identified for qualitative analysis. None of them strictly met with the inclusion criteria and meta-analysis was impossible. There was a tendency towards better overall survival for the primary tumor resected group in all 8 studies, in which 6 demonstrated significant difference...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28027088/feasibility-of-automated-propofol-sedation-for-transcatheter-aortic-valve-implantation-a-pilot-study
#13
Cédrick Zaouter, Thomas M Hemmerling, Stefano Mion, Lionel Leroux, Alain Remy, Alexandre Ouattara
BACKGROUND: Recently, several trials have shown that closed-loop sedation is feasible. No study has used automated sedation in extremely frail patients, such as those scheduled for transcatheter aortic valve implantation (TAVI). We developed and tested a novel automated sedation system for this kind of population and surgery. The system integrates a decision support system that detects respiratory and hemodynamic events via smart alarms, which provide pertinent/related clinical suggestions and treatment options...
December 22, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28024848/neutron-shielding-for-a-new-projected-proton-therapy-facility-a-geant4-simulation-study
#14
Francesco Cadini, David Bolst, Susanna Guatelli, Chris Beltran, Michael Jackson, Anatoly B Rosenfeld
In this work, we used the Monte Carlo-based Geant4 simulation toolkit to calculate the ambient dose equivalents due to the secondary neutron field produced in a new projected proton therapy facility. In particular the facility geometry was modeled in Geant4 based on the CAD design. Proton beams were originated with an energy of 250MeV in the gantry rooms with different angles with respect to the patient; a fixed 250MeV proton beam was also modeled. The ambient dose equivalent was calculated in several locations of interest inside and outside the facility, for different scenarios...
December 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/28007706/validity-of-three-asthma-specific-quality-of-life-questionnaires-the-patients-perspective
#15
Christian J Apfelbacher, Christina J Jones, Anthony Frew, Helen Smith
OBJECTIVES: It is not known which of the many asthma-specific quality of life (QoL) questionnaires best capture the lived experience of people with asthma. The objective of this study was to explore patients' views of three commonly used asthma-specific QoL questionnaires. DESIGN: Qualitative study using semistructured interviews. SETTING: Primary and secondary care in Brighton and Hove, UK. PARTICIPANTS: 30 adult people with a physician-diagnosis of asthma who were asked to complete the Juniper Asthma Quality of Life Questionnaire (AQLQ-J), the Sydney Asthma Quality of Life Questionnaire (AQLQ-S) and the Living with Asthma Questionnaire (LWAQ) to elicit their views on the content validity of these...
December 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/28006961/key-informants-perceptions-on-the-implementation-of-a-national-program-for-improving-nutritional-status-of-children-in-iran
#16
Delaram Ghodsi, Nasrin Omidvar, Arash Rashidian, Hossein Raghfar, Hassan Eini-Zinab, Marziyeh Ebrahimi
INTRODUCTION: Childhood malnutrition is a major public health issue. Multidisciplinary approach for Improvement of Nutritional Status of Children in Iran was implemented in order to reduce malnutrition among children. OBJECTIVE: This study aimed to evaluate the implementation aspect of the program and to explore key informants' perceptions and experience regarding the factors affected its implementation. METHODS: Data were collected through the review of secondary data and semistructured interviews at national, province, and local levels...
January 1, 2016: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/27986304/kinetic-analysis-of-changes-in-t-and-b-lymphocytes-after-anti-cd20-treatment-in-renal-pathology
#17
Alexis Sentís, Fritz Diekmann, Arturo Llobell, Noemí de Moner, Gerard Espinosa, Jordi Yagüe, Josep Maria Campistol, Eduard Mirapeix, Manel Juan
INTRODUCTION: The main objective of this study is to describe qualitatively and quantitatively the different immune lymphocyte phenotypes of patients with renal disease after treatment with anti-CD20. MATERIAL AND METHODS: Two cohorts of transplanted and autoimmune kidney patients were compared: (1) Those who began treatment with Rituximab, matched (for sex, age and general clinical parameters) with (2) Non-treated control kidney patients. Different analyses were performed: (A) B-lymphocyte subpopulations; (B) T-cell subpopulations; (C) serum levels of BAFF, APRIL, Rituximab and anti-Rituximab; (D) rs396991 polymorphism of CD16a and at different time points for each type of analysis: (i) at baseline, (ii) day 15, (iii) at three and (iv) six months post-antiCD20...
November 17, 2016: Immunobiology
https://www.readbyqxmd.com/read/27976594/a-qualitative-study-exploring-factors-that-influence-enrollment-in-outpatient-cardiac-rehabilitation
#18
Codie R Rouleau, Kathryn M King-Shier, Lianne M Tomfohr-Madsen, Sandeep G Aggarwal, Ross Arena, Tavis S Campbell
PURPOSE: This study explored patients' decision-making about whether or not to enroll in cardiac rehabilitation (CR), an underutilized program that is associated with significantly improved health outcomes. METHOD: Face-to-face interviews were conducted with acute coronary syndrome patients (n = 14) after referral to a local CR center, but prior to program enrollment. Thematic analysis was used to derive themes from interview transcripts. RESULTS: Three themes emerged including anticipated benefit, perceived ability, and contextual influences...
December 15, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27966675/protocol-for-a-feasibility-cluster-randomised-controlled-trial-of-a-peer-led-school-based-intervention-to-increase-the-physical-activity-of-adolescent-girls-plan-a
#19
Simon J Sebire, Mark J Edwards, Rona Campbell, Russell Jago, Ruth Kipping, Kathryn Banfield, Keeley Tomkinson, Kirsty Garfield, Ronan A Lyons, Joanne Simon, Peter S Blair, William Hollingworth
BACKGROUND: Physical activity levels are low amongst adolescent girls, and this population faces specific barriers to being active. Peer influences on health behaviours are important in adolescence and peer-led interventions might hold promise to change behaviour. This paper describes the protocol for a feasibility cluster randomised controlled trial of Peer-Led physical Activity iNtervention for Adolescent girls (PLAN-A), a peer-led intervention aimed at increasing adolescent girls' physical activity levels...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27966369/the-theory-of-agency-and-breastfeeding
#20
Kath Ryan, Victoria Team, Jo Alexander
OBJECTIVE: In this paper, we apply psychological agency theory to women's interviews of their breastfeeding experiences to understand the role of agency in relation to breastfeeding initiation, maintenance and duration. DESIGN: Qualitative, video interviews were collected from 49 women in the UK from a wide range of ethnic, religious, educational and employment backgrounds about their breastfeeding experiences. We undertook secondary analysis of the data focusing on their accounts of vulnerability and agency...
December 14, 2016: Psychology & Health
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