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https://www.readbyqxmd.com/read/29029213/recovery-kinetics-of-radiographic-and-implant-related-revision-patients-following-adult-spinal-deformity-surgery
#1
Peter G Passias, Cyrus M Jalai, Virginie Lafage, Gregory W Poorman, Shaleen Vira, Samantha R Horn, Justin K Scheer, D Kojo Hamilton, Breton G Line, Shay Bess, Frank J Schwab, Christopher P Ames, Douglas C Burton, Robert A Hart, Eric O Klineberg
BACKGROUND: Prior studies have observed similar health-related quality of life (HRQL) in revisions and nonrevision (NR) patients following adult spinal deformity (ASD) correction. However, a novel comparison approach may allow better comparisons in spine outcomes groups. OBJECTIVE: To determine if ASD revisions for radiographic and implant-related complications undergo a different recovery than NR patients. METHODS: Inclusion: ASD patients with complete HRQL (Oswestry Disability Index, Short-Form-36 version 2 (SF-36), Scoliosis Research Society [SRS]-22) at baseline, 6 wk, 1 yr, 2 yr...
October 6, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29029009/the-effect-of-physical-activity-and-cardiorespiratory-fitness-on-all-cause-mortality-in-hong-kong-chinese-older-people
#2
Zhihui Lu, Jean Woo, Timothy Kwok
Background: It is unclear whether physical activity (PA) could predict all-cause mortality independently of cardiorespiratory fitness, and there are relatively few studies evaluating the combined effect of PA and cardiorespiratory fitness on mortality. Methods: We invited 1,242 Chinese older adults aged 69 to 94 years from the MrOs and MsOs cohort (Hong Kong) study for a 7-year follow-up. PA was measured by the Physical Activity Scale of the Elderly (PASE). Cardiorespiratory fitness, expressed as maximal oxygen uptake (VO2max), was assessed by performing symptom-limited maximal exercise testing on an electrically braked bicycle ergometer and 6-meter walk test...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29028981/tofacitinib-in-patients-with-ulcerative-colitis-health-related-quality-of-life-in-phase%C3%A2-3-randomized-controlled-induction-and-maintenance-studies
#3
Julian Panés, Séverine Vermeire, James O Lindsay, Bruce E Sands, Chinyu Su, Gary Friedman, Haiying Zhang, Aaron Yarlas, Martha Bayliss, Stephen Maher, Joseph C Cappelleri, Andrew G Bushmakin, David T Rubin
Background and Aims: Tofacitinib is an oral, small molecule JAK inhibitor that is being investigated for UC. We evaluated healthrelated quality of life [HRQoL] in tofacitinib UC Phase 3 studies. Methods: Patients ≥18 years old in OCTAVE Induction 1 [N=598] and 2 [N=541] with moderately to severely active UC were randomized [1:4] to placebo or tofacitinib 10mg twice daily [BID] for 8 weeks. Subsequently, OCTAVE Sustain re-randomized [1:1:1] clinical responders [N=593] from induction studies to placebo, tofacitinib 5 or 10mg BID for 52 weeks...
September 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29028920/perceived-fatigability-and-objective-physical-activity-in-mid-to-late-life
#4
Amal A Wanigatunga, Eleanor M Simonsick, Vadim Zipunnikov, Adam P Spira, Stephanie Studenski, Luigi Ferrucci, Jennifer A Schrack
Background: Fatigability, defined as fatigue in relation to a standardized task, predicts functional decline in older adults independent of reported tiredness or energy level. Although the sensation of fatigue, tiredness, and energy level adversely affect physical activity (PA), the association between fatigability and objectively measured PA is unknown. Methods: Participants in the Baltimore Longitudinal Study of Aging (n=557, 50% women, aged 50-97) were instructed to wear an Actiheart accelerometer for 7 consecutive days in the free-living environment...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29028919/physical-activity-producing-low-but-not-medium-or-higher-vertical-impacts-is-inversely-related-to-bmi-in-older-adults-findings-from-a-multi-cohort-study
#5
Ahmed Elhakeem, Kimberly Hannam, Kevin C Deere, April Hartley, Emma M Clark, Charlotte Moss, Mark H Edwards, Elaine Dennison, Tim Gaysin, Diana Kuh, Andrew Wong, Cyrus Cooper, Rachel Cooper, Jon H Tobias
Background: High impact physical activity (PA) is thought to improve skeletal health but its relation to other health outcomes are unclear. We investigated associations between PA impact magnitude and body mass index (BMI) in older adults. Methods: Data were from the Cohort for Skeletal Health in Bristol and Avon (COSHIBA), Hertfordshire Cohort Study and MRC National Survey of Health and Development. Vertical accelerations peaks from seven-day hip-worn accelerometer recordings were used to classify PA as low (0...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29028864/predicting-cognitive-functioning-activities-of-daily-living-and-participation-6-months-after-mild-to-moderate-stroke
#6
Madison Bertolin, Ryan Van Patten, Taylor Greif, Robert Fucetola
Objective: Predicting neurocognitive and functional outcomes in stroke is an important clinical task, especially in rehabilitation settings. We assessed acute predictors of cognitive and functional outcomes 6 months after mild to moderate stroke. Methods: We conducted a retrospective analysis of acute clinical data and 6-month follow-up telephone interviews for 498 mild to moderate stroke patients. Predictors were sociodemographic variables, the National Institute of Health Stroke Scale (NIHSS), basic physical measures, the Mesulam Cancellation Test, the Short Blessed Test (SBT), Trails A/B, and the Boston Naming Test...
September 25, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29028796/bak1-is-involved-in-atralf1-induced-inhibition-of-root-cell-expansion
#7
Keini Dressano, Paulo H O Ceciliato, Aparecida L Silva, Juan Carlos Guerrero-Abad, Tábata Bergonci, Fausto Andrés Ortiz-Morea, Marco Bürger, Marcio C Silva-Filho, Daniel S Moura
The rapid alkalinization factor (RALF) peptide negatively regulates cell expansion, and an antagonistic relationship has been demonstrated between AtRALF1, a root-specific RALF isoform in Arabidopsis, and brassinosteroids (BRs). An evaluation of the response of BR signaling mutants to AtRALF1 revealed that BRI1-associated receptor kinase1 (bak1) mutants are insensitive to AtRALF1 root growth inhibition activity. BAK1 was essential for the induction of AtRALF1-responsive genes but showed no effect on the mobilization of Ca2+ and alkalinization responses...
October 13, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29028592/elevation-of-plasma-neutrophil-gelatinase-associated-lipocalin-ngal-levels-in-schizophrenia-patients
#8
Li Wei, Yupeng Du, Wei Wu, Xuyan Fu, Qi Xia
BACKGROUND: Psychiatric diseases are usually accompanied by immune dysregulation and activation of the inflammatory response system. However, the characteristics of immunoinflammatory markers in psychiatric diseases are not well defined. METHODS: Seventy-three patients with psychiatric diseases were divided into four groups, including a schizophrenia group, an anxiety disorder group, a unipolar depression group, and a bipolar disorder group, according to the ICD-10 and DSM-IV codes...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29028579/the-views-of-first-time-mothers-completing-an-intervention-to-reduce-postpartum-weight-retention-a-qualitative-evaluation-of-the-mums-online-study
#9
Paige van der Pligt, Kylie Ball, Kylie D Hesketh, David Crawford, Megan Teychenne, Karen Campbell
BACKGROUND: maternal postpartum weight retention (PPWR) has implications for short and long term weight-related health of both the mother and child. Little is known about how mothers perceive they may be best supported to achieve a healthy postpartum weight and healthy lifestyle behaviours. Evaluating existing postpartum weight focussed intervention strategies is an important step in the planning of future programs aimed at supporting new mothers. AIM: to describe the perspectives of women who completed the mums OnLiNE pilot intervention, regarding the acceptability and effectiveness of a program which aimed to limit PPWR and promote healthy diet and physical activity behaviours in new mothers...
September 21, 2017: Midwifery
https://www.readbyqxmd.com/read/29028572/supramolecular-gels-using-an-amide-functionalized-imidazolium-based-surfactant
#10
Ni Cheng, Qi Kang, Jianhong Xiao, Na Du, Li Yu
Studies on supramolecular gel aggregates via supramolecular interactions are very fascinating and impressive. The interactions of gelator with solvent and inorganic salt can functionalize, activate, or control the properties of supramolecular gels. A lot of work on this area has been done, but all these contributions are only at an early stage. In this work, we tuned the gel formation conditions and properties by using low-molecular-weight gelator (LMWGs), amide-functionalized imidazolium-based surfactant, viz...
October 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29028419/an-innovative-educational-clinical-experience-promoting-geriatric-exercise
#11
Kenneth M Manning, Darien L McNeill, Sandro O Pinheiro, Mitchell T Heflin, Willy M Valencia, Cathy C Lee, Steven C Castle, Leslie Katzel, Jamie Giffuni, Miriam C Morey
Formal educational training in physical activity promotion is relatively sparse throughout the medical education system. We describe an innovative clinical experience in physical activity directed at medical clinicians on a geriatrics rotation. The experience consists of a single 2.5 hour session, in which learners are partnered with geriatric patients engaged in a formal supervised exercise program. The learners are guided through an evidence-based exercise regimen tailored to functional status. This experience provides learners with an opportunity to interact with geriatric patients outside the hospital environment to counterbalance the typical geriatric rotation in which geriatric patients are often seen in clinics or hospitals...
October 13, 2017: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/29028292/dynamics-of-soil-biogeochemical-gas-emissions-shaped-by-remolded-aggregate-sizes-and-carbon-configurations-under-hydration-cycles
#12
Ali Ebrahimi, Dani Or
Changes in soil hydration status affect microbial community dynamics and shape key biogeochemical processes. Evidence suggests that local anoxic conditions may persist and support anaerobic microbial activity in soil aggregates (or in similar hot spots) long after the bulk soil becomes aerated. To facilitate systematic studies of interactions among environmental factors with biogeochemical emissions of CO2 , N2 O and CH4 from soil aggregates, we remolded silt soil aggregates to different sizes and incorporated carbon at different configurations (core, mixed, no addition)...
October 13, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29028272/dietary-carbohydrates-components-of-energy-balance-and-associated-health-outcomes
#13
Harry A Smith, Javier T Gonzalez, Dylan Thompson, James A Betts
The role of dietary carbohydrates in the development of obesity and associated metabolic dysfunction has recently been questioned. Within the last decade, the Scientific Advisory Committee on Nutrition carried out a comprehensive evaluation of the role of dietary carbohydrates in human health. The current review aims to complement and extend this report by providing specific consideration of the effects of the component parts of energy balance, their interactions, and their culmination on energy storage and health...
October 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29028209/digital-implementation-of-the-two-compartmental-pinsky-rinzel-pyramidal-neuron-model
#14
Elahe Rahimian, Soheil Zabihi, Mahmood Amiri, Bernabe Linares-Barranco
It is believed that brain-like computing system can be achieved by the fusion of electronics and neuroscience. In this way, the optimized digital hardware implementation of neurons, primary units of nervous system, play a vital role in neuromorphic applications. Moreover, one of the main features of pyramidal neurons in cortical areas is bursting activities that has a critical role in synaptic plasticity. The Pinsky-Rinzel model is a nonlinear two-compartmental model for CA3 pyramidal cell that is widely used in neuroscience...
October 12, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29028075/safety-of-oral-alpha-lipoic-acid-treatment-in-pregnant-women-a-retrospective-observational-study
#15
E Parente, G Colannino, O Picconi, G Monastra
OBJECTIVE: Alpha-lipoic acid is a natural molecule, which directly or by means of its reduced form, dihydrolipoic acid, exerts antioxidant, anti-inflammatory and immunomodulatory activities, very helpful also in preventing miscarriage and preterm delivery. Used as dietary supplement alpha-lipoic acid was demonstrated to be safe for living organisms even when administered at high doses. However, no study was made so far to verify the safety of its continuous administration on a substantial number of pregnant women...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29028064/nonequilibrium-mode-coupling-theory-for-dense-active-systems-of-self-propelled-particles
#16
Saroj Kumar Nandi, Nir S Gov
The physics of active systems of self-propelled particles, in the regime of a dense liquid state, is an open puzzle of great current interest, both for statistical physics and because such systems appear in many biological contexts. We develop a nonequilibrium mode-coupling theory (MCT) for such systems, where activity is included as a colored noise with the particles having a self-propulsion force f0 and a persistence time τp. Using the extended MCT and a generalized fluctuation-dissipation theorem, we calculate the effective temperature Teff of the active fluid...
October 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/29027720/the-effect-of-different-thermal-treatment-on-the-physical-properties-of-pga-pcl-copolymer-suture-material
#17
K A El-Farahaty, M A El-Bakary, N M El-Sayed
Samples of polyglycolic acid PGA/polycaprolactone PCL copolymer absorbable suture materials, which is called Poliglecaprone PGC copolymer suture, were thermally treated by two different processes. The first method is the direct heat exposure, from 20 to 38 °C, in the surrounding medium. Which is an environmental study. The other method is the annealing process at temperatures ranged from 65, 80, 100, 120, and 140 °C, for two different duration periods 60 and 120 min. This is an extensive technical study...
October 13, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29027602/combining-risk-communication-strategies-to-simultaneously-convey-the-risks-of-four-diseases-associated-with-physical-inactivity-to-socio-demographically-diverse-populations
#18
Eva Janssen, Robert A C Ruiter, Erika A Waters
A single risk factor can increase the risk of developing multiple diseases, but most risk communication research has been conducted in the context of a single disease. We explored which combination of three recommended risk communication strategies is most effective in simultaneously conveying risk estimates of four diseases associated with physical inactivity: colon cancer, stroke, diabetes, and heart disease. Participants (N = 1161, 50% no college experience, 50% racial/ethnic minority) were shown hypothetical risk estimates for each of the four diseases...
October 13, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29027560/recovered-spinel-mnco2o4-from-spent-lithium-ion-batteries-for-enhanced-electrocatalytic-oxygen-evolution-in-alkaline-medium
#19
Subramanian Natarajan, S Anantharaj, Rajesh J Tayade, Hari C Bajaj, Subrata Kundu
A facile way of recovering 3d transition metals of industrial importance from spent lithium-ion batteries (LIBs) without using any surfactants has been developed. Mn- and Co-rich spent LIBs were chosen as sustainable sources for recovering the oxides of the respective elements. The physical dismantling of Li-ion batteries, chemical leaching with 2 M acetic acid, precipitation with ammonium carbonate, hydrothermal conditioning and calcination at 650 °C led to the facile formation of spherical spinel MnCo2O4 with very high morphological selectivity...
October 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29027544/long-term-effects-of-exercise-and-physical-therapy-in-people-with-parkinson-disease
#20
REVIEW
Margaret K Mak, Irene S Wong-Yu, Xia Shen, Chloe L Chung
Parkinson disease (PD) is a progressive, neurodegenerative movement disorder with symptoms reflecting various impairments and functional limitations, such as postural instability, gait disturbance, immobility and falls. In addition to pharmacological and surgical management of PD, exercise and physical therapy interventions are also being actively researched. This Review provides an overview of the effects of PD on physical activity - including muscle weakness, reduced aerobic capacity, gait impairment, balance disorders and falls...
October 13, 2017: Nature Reviews. Neurology
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