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https://www.readbyqxmd.com/read/27910264/vaccination-against-h9n2-avian-influenza-virus-reduces-bronchus-associated-lymphoid-tissue-formation-in-cynomolgus-macaques-after-intranasal-virus-challenge-infection
#1
Misako Nakayama, Hiroichi Ozaki, Yasushi Itoh, Kosuke Soda, Hirohito Ishigaki, Masatoshi Okamatsu, Yoshihiro Sakoda, Chun-Ho Park, Hideaki Tsuchiya, Hiroshi Kida, Kazumasa Ogasawara
H9N2 avian influenza virus causes sporadic human infection. Since humans do not possess acquired immunity specific to this virus, we examined the pathogenicity of an H9N2 virus isolated from a human and then analyzed protective effects of a vaccine in cynomolgus macaques. After intranasal challenge with A/Hong Kong/1073/1999 (H9N2) (HK1073) isolated from a human patient, viruses were isolated from nasal and tracheal swabs in unvaccinated macaques with mild fever and body weight loss. A formalin-inactivated H9N2 whole particle vaccine derived from our virus library was subcutaneously inoculated to macaques...
December 2016: Pathology International
https://www.readbyqxmd.com/read/27906082/secondary-correction-of-nasal-deformities-in-cleft-lip-and-palate-patients-surgical-technique-and-outcome-evaluation
#2
Gabor Vass, Gabor Mohos, Zsofia Bere, Laszlo Ivan, Janos Varga, Jozsef Piffko, Laszlo Rovo
BACKGROUND: Nasal deformity associated with cleft lip and palate is a highly challenging reconstructive problem in rhinoplasty. In the literature, several operative solutions and evaluation methods have been described, however these do not offer a standard procedure for the surgeon. Our aim was to standardize our surgical technique-as much as the uniqueness of each case allowed it-based on the most frequent deformities we had faced; and to evaluate our results via a postoperative patient satisfaction questionnaire...
December 1, 2016: Head & Face Medicine
https://www.readbyqxmd.com/read/27899011/nasal-lavage-blood-or-sputum-which-is-best-for-phenotyping-asthma
#3
Camyla F de Farias, Maria M F Amorim, Michel Dracoulakis, Lilian B Caetano, Ilka L Santoro, Ana L G Fernandes
BACKGROUND AND OBJECTIVE: Determination of asthma phenotypes, particularly inflammatory phenotypes, helps guide treatment and management of this heterogeneous disease. Induced sputum cytology has been the gold standard for determination of inflammatory phenotypes, but sputum induction is fairly invasive and technically challenging. Blood and nasal lavage cytology have been suggested as substitutes, but have not been fully verified. The aim of this study is to determine the accuracy of blood and nasal lavage cytometry as indicators of inflammatory phenotypes in asthma...
November 29, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27896197/a-refined-technique-for-management-of-nasal-flaring-the-quest-for-the-holy-grail-of-alar-base-modification
#4
Kapil S Agrawal, Mansi Pabari, Raghav Shrotriya
"A smile is happiness you'll find right under your nose"- Tom Wilson. This quote holds true just for patients, not for surgeons. The correction of the nose always poses a challenge to the cosmetic surgeon. Deformities of the external and internal nose may be congenital or acquired and may be secondary to soft tissue and/or osseo-cartilaginous abnormalities, leading to aesthetic and/or functional consequences. Alar flare poses a common problem, sometimes alone and sometimes in conjunction with other external deformities...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27895878/evaluation-of-visibility-of-foreign-bodies-in-the-maxillofacial-region-comparison-of-computed-tomography-cone-beam-computed-tomography-ultrasound-and-magnetic-resonance-imaging
#5
Solmaz Valizadeh, Hamidreza Pouraliakbar, Leila Kiani, Yaser Safi, Leila Alibakhshi
BACKGROUND: Detection of foreign bodies (FBs) is challenging. Selection of a fast and affordable imaging modality to locate the FB with minimal patient radiation dose is imperative. OBJECTIVES: This study sought to compare four commonly used imaging modalities namely cone beam computed tomography (CBCT), magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound (US) for detection of FBs in the head and neck region. MATERIALS AND METHODS: In this in vitro study, iron, glass, stone, wood, asphalt, and tooth samples measuring 0...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27891327/analysis-of-fetal-palate-to-assist-pre-natal-ultrasound
#6
Anjali Shastry, Yogitha Ravindranath, Roopa Ravindranath
INTRODUCTION: Cleft palate is one of the major facial congenital malformation in newborns. Pre-natal detection of this malformation is limited to detection of clefting of hard palate but isolated soft palate clefting still remains challenge for sonologists. As Indian literature is limited present study was attempted to provide dimensions and position of fetal palate by digitized images. AIM: To study dimensions, position and differences in parameters between second and third trimester fetuses...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891156/usefulness-of-component-resolved-analysis-of-cat-allergy-in-routine-clinical-practice
#7
Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus, Moritz Gröger
BACKGROUND: Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization and allergy are known risk factors for rhinitis, bronchial hyperreactivity and asthma. Thus, the diagnosis of sensitization to cats is important for any allergist. METHODS: 70 patients with positive skin prick tests for cats were retrospectively compared regarding their skin prick test results, as well as their specific immunoglobulin E antibody profiles with regard to their responses to the native cat extract, rFel d 1, nFel d 2 and rFel d 4...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27885206/long-term-follow-up-of-a-case-of-apple-allergy-with-systemic-symptoms-through-oral-food-challenges
#8
Tomoyuki Asaumi, Sakura Sato, Noriyuki Yanagida, Mikita Yamamoto, Motohiro Ebisawa
To our knowledge, there are no previous reports of apple allergy with systemic symptoms for which repeated oral food challenges were performed over a long follow-up. The patient was an 8-year-old boy with hay fever. He visited our hospital because of nasal drop, itchy eyes, and dyspnea after lunch every two months for 2 years. Apple allergy was suspected through his medical interview and specific immunoglobulin (Ig) E levels, and he consequently underwent an oral food challenge test. Ninety minutes after ingestion of one whole apple, he experienced coughing, nasal drop, eyelid edema, and conjunctival injection...
2016: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/27884476/systemic-immunization-with-rpotd-reduces-streptococcus-pneumoniae-nasopharyngeal-colonization-in-mice
#9
T R Converso, C Goulart, D Rodriguez, M Darrieux, L C C Leite
Streptococcus pneumoniae (pneumococcus) is a human pathogen that can cause otitis media, pneumonia and, in severe cases, meningitis and bacteremia. The pneumococcus expresses PotD, a protein belonging to the polyamines transporter complex called PotABCD. PotD is a membrane-associated protein that binds polyamines and has been shown to be important for virulence. In this work we demonstrate that subcutaneous immunization with rPotD reduces the bacterial load in the nasal tissue of mice, following intranasal challenge with a type 6B pneumococcus...
November 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27883982/exocranial-surfaces-for-sex-assessment-of-the-human-cranium
#10
Barbora Musilová, Ján Dupej, Jana Velemínská, Kathia Chaumoitre, Jaroslav Bruzek
Determination of sex is one of the most important and challenging disciplines in biological anthropology. Creating a robust tool for sexing crania is crucial for forensic anthropology, especially in this period of migration, travel, and globalization, when different populations are mixed together in one region. Many different approaches to sex estimation using the skull have been published; however, population specificity and oscillation of variable sexual dimorphism typically reduces their effectiveness. The aim of this study was to create a robust classifier using virtual anthropology without the use of a CT scanner...
November 11, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27877057/chronic-sphenoid-rhinosinusitis-management-challenge
#11
REVIEW
Natamon Charakorn, Kornkiat Snidvongs
Chronic sphenoid rhinosinusitis is a spectrum of inflammatory diseases in isolated sphenoid sinus which may persist over a period of 12 weeks. It is a different entity from other types of rhinosinusitis because clinical presentations include headache, visual loss or diplopia, and patients may or may not have nasal obstruction or nasal discharge. Nasal endoscopic examination is useful, and computed tomography is mandatory. The disease requires comprehensive knowledge and appropriate imaging technique for diagnosis...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27876202/an-interferon-inducing-porcine-reproductive-and-respiratory-syndrome-virus-vaccine-candidate-elicits-protection-against-challenge-with-the-heterologous-virulent-type-2-strain-vr-2385-in-pigs
#12
Eve Fontanella, Zexu Ma, Yanjin Zhang, Alessandra M M G de Castro, Huigang Shen, Patrick G Halbur, Tanja Opriessnig
Achieving consistent protection by vaccinating pigs against porcine reproductive and respiratory syndrome virus (PRRSV) remains difficult. Recently, an interferon-inducing PRRSV vaccine candidate strain A2MC2 was demonstrated to be attenuated and induced neutralizing antibodies. The objective of this study was to determine the efficacy of passage 90 of A2MC2 (A2P90) to protect pigs against challenge with moderately virulent PRRSV strain VR-2385 (92.3% nucleic acid identity with A2MC2) and highly virulent atypical PRRSV MN184 (84...
November 18, 2016: Vaccine
https://www.readbyqxmd.com/read/27857519/vitamin-e-effect-in-a-rat-model-of-toluene-diisocyanate-induced-asthma
#13
Andrea Daniela Muti, Alina Elena Pârvu, Leon Adrian Muti, Remus Moldovan, Adriana Mureşan
BACKGROUND AND AIM: The aim of the study was to evaluate vitamin E effect upon oxidative stress associated with toluene -2, 4-diisocyanate (TDI)-induced asthma in rats. METHODS: The five study groups were: control, vehicle, TDI, vehicle+E, TDI+E. TDI animals were sensitized by nasal administration of TDI 10% (5μl/nostril) between days 1-7 and 15-21. Between days 22-28 groups TDI+E and vehicle+E rats received vitamin E (50 mg/kg, i. v.), and control, vehicle and TDI groups received saline solution...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27853945/endoscopic-closure-of-large-septal-perforations-with-bilateral-hadad-bassagasteguy-flaps
#14
Eduardo Morera Serna, Luis Ferrán de la Cierva, Meritxell Tomás Fernández, Santiago Quer Canut, Jacoba Alba Mesquida, Francisco José García Purriños
: Surgical closure of nasal septal perforations is one of the most challenging procedures in nasal surgery. Defects greater than 2 cm are especially difficult to repair with the traditional approaches due to the challenges of mobilizing enough mucosa to close big gaps, and avoiding airway stenosis in the process. We present a new technique to endoscopically close major septal perforations using bilateral Hadad-Bassagasteguy flaps. Four consecutive patients with septal perforations greater than 2 cm were operated at our institution...
November 16, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27853012/outcomes-of-endoscopic-dacryocystorhinostomy-experience-of-a-fellowship-trainee-at-a-tertiary-care-center
#15
Saurabh Kamal, Mohammad Javed Ali, Akshay Gopinathan Nair
AIM: The study aims to report a single trainee's experience of learning and performing endoscopic endonasal dacryocystorhinostomy (En-DCR). SETTINGS AND DESIGN: This study was a retrospective, interventional case series. SUBJECTS AND METHODS: Fifty-four eyes of fifty patients presenting at a tertiary eye care center over 1 year were included in the study. All cases underwent endoscopic DCR with mitomycin-C and silicone intubation. The parameters studied included demographics, clinical features, intraoperative details, and postoperative ostium evaluation...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27852959/percutaneous-dilatational-tracheostomy-in-ankylosing-spondylitis-bechterew-disease-is-feasible-and-not-associated-with-higher-complication-rates
#16
Uwe Hamsen, Oliver Kamp, Chris Kaczmarek, Mirko Aach, Christian Waydhas, Thomas A Schildhauer, Oliver Jansen
BACKGROUND: Ankylosing spondylitis (AS) is a common disease with an incidence of approximately 0.5% in Europe, causing severe limitations of axial spine mobility and cervical kyphosis. Deformities of the cervical spine and the temporomandibular joints could increase the risk of complications while performing an intubation or tracheostomy. The percutaneous dilatational tracheostomy (PDT) is a standard procedure in intensive care medicine. However, the combination of cervical kyphosis and osteoporosis makes patient positioning challenging...
November 15, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/27852361/-lower-airway-abnormalities-in-patients-with-allergic-rhinitis
#17
J F Ji, Q P Wang, Y Zhang, Z Y Wang, Y Q Xie, W J Guan, K M Wu, L Xu, W Chen, F Xue, M J Jiang, T Y Wang, N S Zhong
Objective: To investigate the characteristics of lower airway abnormalities in allergic rhinitis(AR) patients without asthma. Methods: Between June 2008 and December 2012, 377 consecutive AR patients and 264 healthy subjects were recruited. All subjects underwent meticulous history taking, nasal examination, allergen skin prick test, blood routine test, serum total immunoglobin E assay, induced sputum cell count and differentials, measurement of fractional exhaled nitric oxide (FeNO) and bronchial challenge test...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27846872/challenges-on-non-invasive-ventilation-to-treat-acute-respiratory-failure-in-the-elderly
#18
REVIEW
Raffaele Scala
Acute respiratory failure is a frequent complication in elderly patients especially if suffering from chronic cardio-pulmonary diseases. Non-invasive mechanical ventilation constitutes a successful therapeutic tool in the elderly as, like in younger patients, it is able to prevent endotracheal intubation in a wide range of acute conditions; moreover, this ventilator technique is largely applied in the elderly in whom invasive mechanical ventilation is considered not appropriated. Furthermore, the integration of new technological devices, ethical issues and environment of treatment are still largely debated in the treatment of acute respiratory failure in the elderly...
November 15, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27846021/caudal-septum-surgery-techniques-reviewed
#19
Roxana Cobo, Angie Caldas
PURPOSE OF REVIEW: The caudal septum has important functional and aesthetic implications. Deviations in this area can result in important nasal obstruction due not only to blockage of the nasal passage but also to compromise of the internal nasal valve. Cosmetically, alterations in the caudal septum can result in a twisted nasal tip, loss of projection, rotation, and imbalance in the ala-columellar relationship. Contemporary surgical options will be discussed showing how to preserve, reshape, and reinforce the caudal septum to obtain a final looking nose that is not only functional but also aesthetically pleasing...
November 14, 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27844410/the-great-mimicker-metastatic-breast-carcinoma-to-the-head-and-neck-with-emphasis-on-unusual-clinical-and-pathologic-features
#20
Dikson Dibe Gondim, Rebecca Chernock, Samir El-Mofty, James S Lewis
Distant metastases are relatively common in breast cancer, but spread to the head and neck region is uncommon and can be diagnostically challenging. Pathology databases of two academic hospitals were searched for patients. The diagnoses were by morphologic comparison with the primary breast specimen (when available) or through the use of immunohistochemical stains characteristic of breast carcinoma (cytokeratin 7, mammaglobin, GCDFP15, and/or GATA3 positive-excluding new primary tumors at the respective head and neck sites)...
November 14, 2016: Head and Neck Pathology
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