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https://www.readbyqxmd.com/read/29336284/assessing-the-onset-of-allergic-rhinitis-by-nasal-cytology-and-immunoglobulin-e-antibody-levels-in-children
#1
Hirokuni Otsuka, Kuninori Otsuka, Shoji Matsune, Kimihiro Okubo
BACKGROUND: It is difficult to identify the onset of allergic rhinitis in infants because making a conclusive diagnosis can be challenging. OBJECTIVE: We used a combination of cell differentials in nasal swabs and immunoglobulin E (sIgE) antibody values to food and inhalant allergens to make the diagnosis and identify relevant allergens for investigation of the onset of allergic rhinitis. METHODS: We studied 302 children, 2 to 120 months old, who visited our clinic for rhinorrhea...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29324473/chondromyxoid-fibroma-arising-in-craniofacial-sites-a-clinicopathologic-analysis-of-25-cases
#2
David M Meredith, Christopher D M Fletcher, Vickie Y Jo
Chondromyxoid fibroma (CMF) is a rare benign tumor, usually arising in the metaphysis of long bones in young adults. Occurrence in craniofacial bones presents a particular diagnostic challenge given its unusual location and resemblance to malignant mimics. We describe the clinicopathologic features of 25 cases of craniofacial CMF identified between 1999 and 2017. Patients were 14 men and 11 women, with median age of 44 years (range, 5 to 83 y). Sites of involvement were sphenoid (7), ethmoid (5), maxilla (3), occipital (2), nasal septum (2), palatine (2), temporal (2), orbit (1), and undisclosed skull (1)...
January 10, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29319787/dorsal-preservation-the-push-down-technique-reassessed
#3
Yves Saban, Rollin K Daniel, Roberto Polselli, Maria Trapasso, Peter Palhazi
Management of the nasal dorsum remains a challenge in rhinoplasty surgery. Currently, the majority of reduction rhinoplasties results in destruction of the keystone area (K-area), which requires reconstruction with either spreader grafts or spreader flaps, both for aesthetic and functional reasons. This article will present the senior author's current operative technique for dorsal preservation in reduction rhinoplasty based on 320 clinical cases performed over a 5-year period. The author's operative technique is as follows: (1) endonasal approach; (2) removal of a septal strip in the subdorsal area whose shape and height were determined preoperatively; (3) complete lateral, transverse, and radix osteotomies; and (4) dorsal reduction utilizing either a push down operation (PDO) or a let down operation (LDO)...
January 8, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29291221/evaluating-the-efficacy-of-lasota-vaccination-induced-protection-in-chickens-upon-challenge-with-a-genotype-iv-strain-of-newcastle-disease-virus
#4
S Bhuvaneswari, K G Tirumurugaan, P Venkatesan, P Manesh Kumar, K Kumanan
Newcastle disease (ND) is a major risk to the poultry industry which results in severe economic loss throughout the world even with vaccination. The vaccine viruses that are used in many countries include the LaSota and other live viruses that were isolated in the early and late 1950s. Reports from several laboratories including ours indicate a greater variance of the circulating strains and recent classification indicates the existence of XVIII different genotypes of NDV strains. The efficiency of the LaSota vaccination in inducing protective immunity to different heterologous strains has been a question and its efficacy upon exposure to a virulent genotype IV strain has not been reported after 1989 world-wide except for India...
September 2017: Virusdisease
https://www.readbyqxmd.com/read/29290097/challenges-in-developing-mucosal-vaccine-and-antibodies-against-infectious-diarrhea-in-children
#5
REVIEW
Daisuke Tokuhara
Infectious diarrhea in children can be life-threatening and imposes a large economic burden on healthcare systems, therefore more effective prophylactic and therapeutic drugs are needed urgently. Because most of the pathogens responsible for childhood diarrhea infect the gastrointestinal mucosa, providing protective immunity at the mucosal surface is an ideal way to control pathogen invasion and toxic activity. Mucosal (e.g., oral, nasal) vaccines are superior to systemic (subcutaneous or intramuscular) vaccination for conferring both mucosal and systemic pathogen-specific immune responses...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29281844/-decolonization-of-health-care-workers-in-a-neonatal-intensive-care-unit-carrying-a-methicillin-susceptible-staphylococcus-aureus-isolate
#6
Annika Richter, Ines Eder, Brigitte König, Bettina Lutze, Arne C Rodloff, Ulrich H Thome, Melanie Weiss, Iris F Chaberny
BACKGROUND: In 2016, an increased rate of methicillin-susceptible Staphylococcus aureus colonization was detected on a neonatal intensive care unit at the Leipzig University Hospital. Typing results showed a predominant spa-type t091. Considering nosocomial clustering, several infection prevention measures (e. g. intensified standard precautions, single-occupancy room, cohorted patients, continuing education of staff) were introduced, including staff screening followed by decolonization of colonized health care workers...
December 27, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29280883/evidence-based-medicine-current-practices-in-rhinoplasty
#7
REVIEW
Neil Tanna, Khang T Nguyen, Ashkan Ghavami, Jay W Calvert, Bahman Guyuron, Rod J Rohrich, Ronald P Gruber
LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Perform aesthetic and functional nasal analysis to guide septorhinoplasty. 2. Recognize common complications associated with rhinoplasty. 3. Select appropriate septorhinoplasty techniques to refine nasal aesthetics and treat nasal airway obstruction. 4. Identify factors leading to poor patient satisfaction following rhinoplasty. SUMMARY: Septorhinoplasty is among the most technically challenging procedures in the realm of plastic and reconstructive surgery...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29279055/chronic-rhinosinusitis-with-nasal-polyps-in-the-elderly-assessing-current-evidence
#8
Gino Marioni, Claudia Zanotti, Giuseppe Brescia
BACKGROUND: The recently reported prevalence of chronic rhinosinusitis (CRS) among people >60 years old was 4.7%, with CRS emerging as the sixth most common chronic condition in the elderly. There is still a dearth of studies that focused on older patients, however, regarding the characteristics of CRS with nasal polyps (CRSwNP). OBJECTIVE: The emerging role of CRSwNP endotyping to enable a tailored medical approach (for elderly patients also) was investigated...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29277310/mechanism-of-intranasal-drug-delivery-directly-to-the-brain
#9
REVIEW
Tyler P Crowe, M Heather West Greenlee, Anumantha G Kanthasamy, Walter H Hsu
Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge is to administer drugs intranasally to noninvasively bypass the blood-brain barrier. The intranasal route can thus transport drugs directly to the brain from the nasal cavity along the olfactory and trigeminal nerves...
December 22, 2017: Life Sciences
https://www.readbyqxmd.com/read/29273075/management-of-pneumothorax-in-hemodynamically-stable-preterm-infants-using-high-frequency-oscillatory-ventilation-report-of-five-cases
#10
Claudia Aurilia, Cinzia Ricci, Milena Tana, Chiara Tirone, Alessandra Lio, Alessandro Gambacorta, Angela Paladini, Giovanni Vento
BACKGROUND: Despite an increased use of non-invasive ventilatory strategies and gentle ventilation, pneumothorax remains a common complication in preterm infants. The ventilator management of infants with air leaks remains challenging in terms of both prevention and treatment. Recently the safety and efficacy of expectant management avoiding chest tube drainage to treat large air leak in preterm infants hemodynamically stable has been reported. CASE PRESENTATION: In the present study, we report five cases of preterm infants with birth weight ≤ 1250 g affected by respiratory distress syndrome and treated with nasal continuous positive airway pressure as first intention...
December 22, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29249137/occupational-allergy-to-spagulax%C3%A2-plantago-ovata-seed
#11
M Viñas, F Pineda, A Izquierdo-Domínguez, M Castillo, M J Castillo, N Hernández, M Ibero
We report the case of a 36-year-old male pharmaceutical laboratory worker. On handling Spagulax® sachets whose content is a laxative called Plantago ovata, he immediately presented rhinoconjunctivitis. Methods. Specific allergy study included SDS-PAGE with Western Blot and specific nasal challenge to Plantago ovata extract. Results. Prick by prick for Spagulax® was negative. Total IgE: 126.5 U/mL. Western Blot recognized two proteins of 15 and 20 kDa in the extract of Plantago ovata and three proteins of 15, 18 and 50 kDa in the extract of Plantago lanceolata...
November 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29246634/genetics-of-bi-component-leukocidin-and-drug-resistance-in-nasal-and-clinical-staphylococcus-aureus-in-lagos-nigeria
#12
Nkechi V Enwuru, Solayide A Adesida, Christian A Enwuru, Beniam Ghebremedhin, Udoma E Mendie, Akitoye O Coker
BACKGROUND: Resistant and virulent Staphylococcus aureus is a global public health challenge. Staphylococcal Bi-component leukotoxins are cytolytic to immune cells and evolve to disarm the innate immunity during infections, hence the severity of the disease. OBJECTIVE: We studied drug resistance profile and the occurrence of bi-component leukocidin in clinical and nasal S. aureus in Lagos, Nigeria. METHOD: Ninety-two S. aureus (70 clinical and 22 nasal) strains were characterized by conventional and molecular methods...
December 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29243108/identification-of-a-novel-high-yielding-source-of-multipotent-adult-human-neural-crest-derived-stem-cells
#13
Matthias Schürmann, Viktoria Brotzmann, Marlena Bütow, Johannes Greiner, Anna Höving, Christian Kaltschmidt, Barbara Kaltschmidt, Holger Sudhoff
Due to their extraordinarily broad differentiation potential and persistence during adulthood, adult neural crest-derived stem cells (NCSCs) are highly promising candidates for clinical applications, particularly when facing the challenging treatment of neurodegenerative diseases or complex craniofacial injuries. Successful application of human NCSCs in regenerative medicine and pharmaceutical research mainly relies on the availability of sufficient amounts of tissue for cell isolation procedures. Facing this challenge, we here describe for the first time a novel population of NCSCs within the middle turbinate of the human nasal cavity...
December 14, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29237065/methicillin-resistant-staphylococcus-aureus-in-papua-new-guinea-a-community-nasal-colonization-prevalence-study
#14
Moses Laman, Andrew Greenhill, Geoffrey W Coombs, Owen Robinson, Julie Pearson, Timothy M E Davis, Laurens Manning
Background: There are few epidemiological data available to inform a national response to community-acquired methicillin-resistant Staphylococcus aureus (MRSA) in Papua New Guinea (PNG). Methods: We performed a cross-sectional survey to determine the pattern of MRSA nasal colonization and the diversity of circulating MRSA clones among adults and adolescents in Madang Province, PNG. Results: S. aureus nasal colonization was confirmed in 44 (17...
December 11, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29236765/chondrocytes-and-stem-cells-in-3d-bioprinted-structures-create-human-cartilage-in-vivo
#15
Peter Apelgren, Matteo Amoroso, Anders Lindahl, Camilla Brantsing, Nicole Rotter, Paul Gatenholm, Lars Kölby
Cartilage repair and replacement is a major challenge in plastic reconstructive surgery. The development of a process capable of creating a patient-specific cartilage framework would be a major breakthrough. Here, we described methods for creating human cartilage in vivo and quantitatively assessing the proliferative capacity and cartilage-formation ability in mono- and co-cultures of human chondrocytes and human mesenchymal stem cells in a three-dimensional (3D)-bioprinted hydrogel scaffold. The 3D-bioprinted constructs (5 × 5 × 1...
2017: PloS One
https://www.readbyqxmd.com/read/29236357/live-attenuated-influenza-virus-vaccine-reduces-virus-shedding-of-newborn-piglets-in-the-presence-of-maternal-antibody
#16
Marika Genzow, Christa Goodell, Troy J Kaiser, Wesley Johnson, Marc Eichmeyer
BACKGROUND: Influenza A virus in swine (IAV-S) causes an acute respiratory disease of swine which results in great economic losses in pig production. Major control strategies include the use of killed vaccines (KV) in breeding females to confer passive immunity to their offspring. A bivalent H1N1 and H3N2 NS1-truncated live attenuated IAV-S vaccine has recently become available, which showed promising results in young pigs. OBJECTIVE: The aim of this study was to investigate the effect of an intranasal vaccination of newborn pigs with or without maternally derived antibodies (MDA) on virus shedding (via nasal swabs tested by virus isolation)...
December 13, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29234644/prophylaxis-with-nasal-decolonization-in-patients-submitted-to-total-knee-and-hip-arthroplasty-systematic-review-and-meta-analysis
#17
REVIEW
David Sadigursky, Henrique Santos Pires, Saulo Américo Caldas Rios, Francisco Luiz Borja Rodrigues Filho, Gustavo Castro de Queiroz, Mateus Lemos Azi
Despite the evolution of the total knee and hip arthroplasty surgery, high postoperative complication rates in the short and long term still persist. Infection is one of the most challenging complications; due to its gravity and treatment difficulties, prophylaxis protocols have been created to decrease its incidence. The objective of this study was to evaluate the impact of the prophylaxis protocol for methicillin-resistant Staphylococcus aureus decolonization of the nares in patients previously identified by swab cultures, who were to be submitted to a total joint arthroplasty...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29229733/expression-of-tlr2-by-dendritic-cells-is-essential-for-dnaj-%C3%AE-a146ply-mediated-th1-immune-response-against-streptococcus-pneumoniae
#18
Xiaofang Wang, Taixian Yuan, Jun Yuan, Yufeng Su, Xiaoyu Sun, Jingwen Wu, Hong Zhang, Xun Min, Xuemei Zhang, Yibing Yin
The fusion protein, DnaJ-ΔA146Ply, could induce cross-protective immunity against pneumococcal infection via mucosal and subcutaneous immunization in mice in the absence of additional adjuvants. DnaJ and Ply are both TLR4 but not TLR2 ligands. However, we found that TLR2-/- mice immunized subcutaneously with DnaJ-ΔA146Ply showed significantly lower survival rates and higher bacterial loads in nasal washes than those of WT mice after being challenged with pneumococcal strains D39 or 19F. The IFN-γ level in splenocytes decreased in TLR2-/- mice, indicating that Th1 immunity elicited by DnaJ-ΔA146Ply was impaired in TLR2-/- mice...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29228270/influenza-a-virus-subtype-h9n2-infection-disrupts-the-composition-of-intestinal-microbiota-of-chickens
#19
Alexander Yitbarek, J Scott Weese, Tamiru Negash Alkie, John Parkinson, Shayan Sharif
The impact of low pathogenic influenza viruses such as subtype H9N2, which infect the respiratory and the gastrointestinal tracts of chickens, on microbial composition are not known. Twenty day-old specific pathogen free chickens were assigned to two treatment groups, control (Uninfected) and H9N2-infected (challenged via the oral-nasal route). Fecal genomic DNA was extracted, and the V3-V4 regions of the 16S rRNA gene was sequenced using the Illumina Miseq® platform. Sequences were curated using Mothur as described in the MiSeq SOP...
December 6, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29228010/nasal-carriage-of-methicillin-resistant-staphylococcus-aureus-mrsa-at-a-palliative-care-unit-a-prospective-single-service-analysis
#20
Maria Heckel, Walter Geißdörfer, Franziska A Herbst, Stephanie Stiel, Christoph Ostgathe, Christian Bogdan
BACKGROUND: The emergence of multidrug-resistant bacterial microorganisms is a particular challenge for the health care systems. Little is known about the occurrence of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Gram-negative bacteria (MDRGNB) in patients of palliative care units (PCU). AIM: The primary aim of this study was to determine the carriage of MRSA among patients of a PCU at a German University Hospital and to assess whether the positive cases would have been detected by a risk-factor-based screening-approach...
2017: PloS One
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