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https://www.readbyqxmd.com/read/29136342/direct-intranasal-application-of-the-solid-phase-of-immunocap%C3%A2-increases-nasal-specific-immunoglobulin-e-detection-in-local-allergic-rhinitis-patients
#1
Paloma Campo, María Del Carmen Plaza-Seron, Ibon Eguiluz-Gracia, Jesús Verge, Luisa Galindo, Esther Barrionuevo, Javier Fernandez, Raquel Jurado, Cristobalina Mayorga, María José Torres, Carmen Rondón
BACKGROUND: The measurement of nasal specific IgE (NsIgE) in local allergic rhinitis (LAR) patients is challenging and shows variability. The objective of this work was to evaluate a minimally-invasive method of direct detection of NsIgE in patients with LAR to Dermatophagoides pteronyssinus (DP) using an automated immunoassay. METHODS: Fifty patients participated (LAR, n = 14; allergic rhinitis (AR), n = 20; healthy controls [HC], n = 16). Detection of NsIgE was performed by direct application of the solid phase of a commercial DP ImmunoCAP® test 24 hours after DP nasal provocation...
November 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29128670/synchronous-immune-alterations-mirror-clinical-response-during-allergen-immunotherapy
#2
Amedee Renand, Mohamed H Shamji, Kristina M Harris, Tielin Qin, Erik Wambre, Guy W Scadding, Peter A Wurtzen, Stephen J Till, Alkis Togias, Gerald T Nepom, William W Kwok, Stephen R Durham
BACKGROUND: Three years treatment with either sublingual or subcutaneous allergen immunotherapy has been shown to be effective and to induce long-term tolerance. The GRASS(∗) trial demonstrated that two years treatment via either route was effective in suppressing the response to nasal allergen challenge, although was insufficient for inhibition one year after discontinuation. OBJECTIVE: To examine in the GRASS trial the time-course of immunologic changes during two years sublingual and subcutaneous immunotherapy and for one year after treatment discontinuation...
November 8, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29127249/-18-f-fdg-pet-ct-for-monitoring-response-to-therapy-of-choroidal-metastasis
#3
Naghmehossadat Eshghi, John Christoforidis, Phillip Kuo
A 38-year-old woman with metastatic breast carcinoma reported seeing "halos and flashes" in her left eye. Funduscopic exam revealed an elevated mass in the choroid of the left globe consistent with metastasis. Subsequent (18)F-FDG PET/CT revealed focal uptake in the nasal aspect of the left choroid of the eye corresponding to the mass seen on the funduscopic exam. Through correlation with the PET/CT, the lesion was retrospectively identified on the MRI. (18)F-FDG PET/CT post-radiotherapy showed complete response and thus supports that this imaging modality can be used for diagnosis and monitoring response...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29126262/relapsing-polychondritis-a-clinical-review-for-rheumatologists
#4
Jack Kingdon, Joseph Roscamp, Shirish Sangle, David D'Cruz
Relapsing polychondritis (RPC) is a rare autoimmune rheumatic disorder that is traditionally classified as a systemic vasculitis. It is characterized by inflammation of cartilage, and typical presenting features include chondritis of the nasal bridge, auricular chondritis, ocular inflammation and involvement of the bronchial tree. Its rarity often leads to considerable delay in establishing a diagnosis and poses a significant management challenge to clinicians, as no conventional guidelines exist. This review summarizes the clinical features of RPC and provides guidance for rheumatologists on making the diagnosis and assessing organ involvement...
November 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/29124376/an-alternative-rhinoplasty-technique-rotational-spreader-flap-rabbit-flap
#5
Ali Ahmet Sirin, Ibrahim Erdim, Omer Erdur, Alperen Sirin
BACKGROUND: In modern rhinoplasty, septal cartilage is the most commonly used graft material. It is a big challenge if septal cartilage is insufficient. We present an alternative technique named the "rabbit flap," created from the cephalic portion of the lower lateral cartilage to show its effectiveness on nasolabial angle, nasal axis deviation, and nasal dorsal line. METHODS: An alternative flap, called a "rabbit flap," is constituted from the cephalic portion of the lower lateral cartilage (LLC)...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29121401/mp29-02-reduces-nasal-hyperreactivity-and-nasal-mediators-in-patients-with-house-dust-mite-allergic-rhinitis
#6
Inge Kortekaas Krohn, Ina Callebaut, Yeranddy A Alpizar, Brecht Steelant, Laura Van Gerven, Per Stahl Skov, Ahmad Kasran, Karel Talavera, Mira M Wouters, Jan L Ceuppens, Sven F Seys, Peter W Hellings
BACKGROUND: Nasal hyperreactivity (NHR) is an important clinical feature of allergic rhinitis (AR). The efficacy of MP29-02 (azelastine hydrochloride (AZE) and fluticasone propionate (FP)) nasal spray on local inflammatory mediators and NHR in AR is unknown. We tested if MP29-02 decreases inflammatory mediators and NHR in AR and if this effect is due to restoration of nasal epithelial barrier function. METHODS: A 4-week double-blinded placebo-controlled trial with MP29-02 treatment was conducted in 28 patients with house dust mite (HDM) AR...
November 9, 2017: Allergy
https://www.readbyqxmd.com/read/29114929/disfiguring-facial-mycoses-a-diagnostic-and-therapeutic-challenge
#7
G H D C Janappriya, C N Gunasekera, B S D N Keragala, B S Dissanayake, P D Liyanagama, V Shanmuhathas, B Thanushah, L S M Sigera, P I Jayasekera
Some fungal infections may lead to devastating destruction of face, sometimes followed by fatal consequences. Conidiobolus coronatus is a rare, but serious emerging fungal pathogen of humans, causing Conidiobolomycosis, commonly infecting nasal mucosa and with potential to extend to involve vital structures such as brain and eyes. Treatment of this infection is extremely difficult and can cause significant disfiguring sequale, unless aggressively treated. We illustrate an interesting case, encountered within a short space of time affected by such infections and emphasize the need for thorough evaluation, investigation and aggressive initial treatment to achieve a good clinical response...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29109835/anterior-submandibular-approach-for-transmylohyoid-endotracheal-intubation-a-reappraisal-with-prospective-study-in-206-cases-of-craniomaxillofacial-fractures
#8
Nitin Bhola, Anendd Jadhav, Atul Kala, Rahul Deshmukh, Umesh Bhutekar, G S V Prasad
Despite a paradigm shift in anesthesia and trauma airway management, the craniomaxillofacial fracture (CMF) patients continue to pose a challenge. A prospective study was planned between April 2007 and March 2015 to investigate the safety, efficacy, utility, and complications of anterior submandibular approach for transmylohyoid intubation (TMI) in CMFs using an armored endotracheal tube (ETT). Out of 1,207 maxillofacial trauma cases reported, this study recruited 206 patients (152 males and 54 females) aged between 21 and 60 years...
December 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29109646/ludwig-s-angina-in-children-anesthesiologist-s-nightmare-case-series-and-review-of-literature
#9
Maitree Pandey, Manpreet Kaur, Manoj Sanwal, Aruna Jain, Sunil K Sinha
Ludwig's angina is potentially lethal, rapidly spreading cellulitis of the floor of mouth and neck. The anticipated difficult airway becomes even more challenging when it occurs in children. In children, the larynx is positioned relatively higher in the neck, and one does not have the option for blind nasal intubation or awake fiberoptic, which otherwise is the technique of choice in adult patients. We present the clinical course of 16 children and highlight various problems encountered during the anesthetic management of six children who required emergency surgical drainage under general anesthesia...
July 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29108012/oral-immunization-of-a-non-recombinant-lactococcus-lactis-surface-displaying-influenza-hemagglutinin-1-ha1-induces-mucosal-immunity-in-mice
#10
Pui-Fong Jee, Vunjia Tiong, Meng-Hooi Shu, Jing-Jing Khoo, Won Fen Wong, Raha Abdul Rahim, Sazaly AbuBakar, Li-Yen Chang
Mucosal immunization of influenza vaccine is potentially an effective approach for the prevention and control of influenza. The objective of the present study was to evaluate the ability of oral immunization with a non-recombinant Lactococcus lactis displaying HA1/L/AcmA recombinant protein, LL-HA1/L/AcmA, to induce mucosal immune responses and to accord protection against influenza virus infection in mice. The LL-HA1/L/AcmA was orally administered into mice and the immune response was evaluated. Mice immunized with LL-HA1/L/AcmA developed detectable specific sIgA in faecal extract, small intestine wash, BAL fluid and nasal fluid...
2017: PloS One
https://www.readbyqxmd.com/read/29107078/randomised-controlled-trial-of-honey-versus-mupirocin-to-decolonise-patients-with-nasal-colonisation-of-methicillin-resistant-staphylococcus-aureus-and-the-lessons-learned
#11
Toney Thomas Poovelikunnel, Georgina Gethin, Damodar Solanki, Elaine McFadden, Mary Codd, Hilary Humphreys
AIM: To describe the learning experience from a randomised controlled trial (RCT) comparing the efficacy of medical-grade honey (MGH) with mupirocin 2% for the eradication of nasal methicillin-resistant Staphylococcus aureus (MRSA). METHODS: Patients colonised in the nose with MRSA and age ≥18 years were recruited. Participants received either one or two courses of MGH or mupirocin 2%, three times per day for five consecutive days. RESULTS: The proportion of patients who were decolonised after one or two courses of treatment was not significantly different between MGH (18/42; 42...
October 26, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29107075/the-role-of-extracellular-histones-in-influenza-virus-pathogenesis
#12
Harshini K Ashar, Nathan C Mueller, Jennifer M Rudd, Timothy A Snider, Mallika Achanta, Maram Prasanthi, Sivasami Pulavendran, Paul G Thomas, Ramachandran Akhilesh, Jerry R Malayer, Jerry W Ritchey, Rachakatla Rajasekhar, Vincent Tk Chow, Charles T Esmon, Narasaraju Teluguakula
Although exaggerated host immune responses have been implicated in influenza-induced lung pathogenesis, the etiological factors that contribute to these events are not completely understood. We have previously demonstrated that neutrophil extracellular traps exacerbate pulmonary injury during influenza pneumonia. Histones are the major protein components of neutrophil extracellular traps and are known to have cytotoxic effects. Here, we examined the role of extracellular histones in lung pathogenesis during influenza...
October 26, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29105347/outcomes-after-complete-endoscopic-sinus-surgery-and-aspirin-desensitization-in-aspirin-exacerbated-respiratory-disease
#13
Nithin D Adappa, Viran J Ranasinghe, Michal Trope, Steven G Brooks, Jordan T Glicksman, Arjun K Parasher, James N Palmer, John V Bosso
BACKGROUND: In this study we assessed patient outcomes after complete endoscopic sinus surgery (ESS) and aspirin desensitization for patients with aspirin-exacerbated respiratory disease (AERD). METHODS: A retrospective chart review was conducted for patients with aspirin challenge-proven AERD who underwent complete ESS followed by aspirin desensitization. Outcomes assessed included need for revision surgery and quality-of-life measures using the 22-item Sino-Nasal Outcomes Test (SNOT-22)...
November 3, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29103995/ectopic-lymphoid-tissues-support-local-immunoglobulin-production-in-chronic-rhinosinusitis-with-nasal-polyps
#14
Jia Song, Hai Wang, Ya-Na Zhang, Ping-Ping Cao, Bo Liao, Zhe-Zheng Wang, Li-Li Shi, Yin Yao, Guan-Ting Zhai, Zhi-Chao Wang, Li-Meng Liu, Ming Zeng, Xiang Lu, Heng Wang, Xiang-Ping Yang, Di Yu, Claus Bachert, Zheng Liu
BACKGROUND: The contribution of ectopic lymphoid tissues (eLTs) to local immunoglobulin (Ig) hyperproduction in chronic rhinosinusitis with nasal polyps (CRSwNP) is unclear. OBJECTIVE: We sought to explore the cellular basis, formation mechanisms, and function of eLTs in CRSwNP. METHODS: We graded lymphoid aggregations in sinonasal mucosa and histologically studied their structures. The expression of lymphorganogenic factors and molecules required for Ig production was measured using real-time PCR and their localization was analyzed by immunohistochemistry and immunofluorescence...
November 2, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29103691/immunogenicity-and-protective-efficacy-of-inactivated-equine-influenza-h3n8-virus-vaccine-in-murine-model
#15
Selvaraj Pavulraj, Nitin Virmani, Bidhan Chandra Bera, Alok Joshi, Taruna Anand, Meenakshi Virmani, Rajendra Singh, Raj Kumar Singh, Bhupendra Nath Tripathi
Equine influenza viruses (EIVs) are responsible for acute contagious respiratory infection in equines and the disease remains a major threat for equine population throughout the world despite vaccination strategies in place. The present study was aimed to assess the suitability of BALB/c mice as a potential small animal model for preliminary screening of EI vaccine candidates. For this, we evaluated the immunogenicity and protective efficacy of an inactivated EIV (H3N8) vaccine in BALB/c mouse model after challenge with homologous H3N8 virus (Clade 2 virus, Florida sublineage) through serology, clinical signs, gross and histopathology lesions with grading, immunohistochemistry and virus quantification...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29103677/enhanced-protection-against-fmdv-in-cattle-after-prime-boost-vaccination-based-on-mucosal-and-inactivated-fmd-vaccine
#16
Manar E Khalifa, Ayman H El-Deeb, Sayed M Zeidan, Hussein A Hussein, Hany I Abu-El-Naga
Improved immunization and control strategies and platforms are greatly needed for foot and mouth disease virus (FMDV) and mucosal vaccines propose an effective strategy for the control FMDV by blocking viral entry. In this study, several immunization strategies, using two FMDV vaccine formulations, including Montanide ISA 206 oil-based FMD inactivated vaccine and Montanide IMS 1313 VG N PR-based concentrated semi-purified FMD mucosal vaccine, were applied. Results of intranasal immunization with the prepared FMD mucosal vaccine, given once or twice, induced IgA levels in both nasal and salivary secretions besides a high response of lymphocyte proliferation with protection levels reaching 20% and 40%, respectively, in a challenge trial in cattle...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29102170/protection-of-vaccinated-mice-against-pneumonic-tularemia-is-associated-with-an-early-memory-sentinel-response-in-the-lung
#17
Liat Bar-On, Hila Cohen, Uri Elia, Shahar Rotem, Adi Bercovich-Kinori, Erez Bar-Haim, Theodor Chitlaru, Ofer Cohen
Francisella tularensis is the intracellular bacterial pathogen causing the respiratory life-threatening disease tularemia. Development of tularemia vaccines has been hampered by an incomplete understanding of the correlates of immunity. Moreover, the importance of lung cellular immunity in vaccine-mediated protection against tularemia is a controversial matter. Live attenuated vaccine strains of F. tularensis such as LVS (Live Vaccine Strain), elicit an immune response protecting mice against subsequent challenge with the virulent SchuS4 strain, yet the protective immunity against pulmonary challenge is limited in its efficacy and longevity...
October 25, 2017: Vaccine
https://www.readbyqxmd.com/read/29089459/choosing-the-proper-interface-for-positive-airway-pressure-therapy-in-subjects-with-acute-respiratory-failure
#18
REVIEW
Ahmed S BaHammam, Tripat Deep Singh, Ravi Gupta, Seithikurippu R Pandi-Perumal
Noninvasive ventilation is an effective treatment for a significant proportion of patients with acute respiratory failure. The success of noninvasive ventilation, however, depends on several factors, a major one being the selection of the proper interface. The choice and application of the interface in patients with acute respiratory failure is a considerable challenge for any treatment team. This review discusses the different types of interfaces that can be used in patients with acute respiratory failure, the differences between nasal, oro-nasal, and total face masks and the helmet, as well as the effect of interface type on treatment success and upper airway patency, mask fitting, problems related to the interface, and the relationship between ventilator type and interface choice...
October 31, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29084330/characterizing-the-natural-history-of-visual-function-in-choroideremia-using-microperimetry-and-multimodal-retinal-imaging
#19
RANDOMIZED CONTROLLED TRIAL
Jasleen K Jolly, Kanmin Xue, Thomas L Edwards, Markus Groppe, Robert E MacLaren
Purpose: Centripetal retinal degeneration in choroideremia (CHM) leads to early visual field restriction and late central vision loss. The latter marks an acute decline in quality of life but visual prognostication remains challenging. We investigated visual function in CHM by correlating best-corrected visual acuity (BCVA), microperimetry and multimodal imaging. Methods: Fifty-six consecutive CHM patients attending Oxford Eye Hospital were examined with BCVA, 10-2 microperimetry, optical coherence tomography, and fundus autofluorescence (AF)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29084005/dysphotopsia-a-multifaceted-optic-phenomenon
#20
Jenny Hu, Ruti Sella, Natalie A Afshari
PURPOSE OF REVIEW: To summarize the literature on dysphotopsia, focusing on strategies for management and prevention. RECENT FINDINGS: Clinical studies and ray-tracing diagrams have improved our understanding of the risk factors for positive and negative dysphotopsiae. Well known management and prevention strategies such as piggyback IOL, reverse optic capture, Nd:YAG capsulotomy, and IOL exchange are reviewed, as well as newer strategies such as the infertemporal approach to IOL implantation, 'in-the-bag nasal optic truncation' and new IOL design implantation, and new IOL design...
October 27, 2017: Current Opinion in Ophthalmology
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