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https://www.readbyqxmd.com/read/29449668/rhinovirus-3c-protease-suppresses-apoptosis-and-triggers-caspase-independent-cell-death
#1
Mark Lötzerich, Pascal S Roulin, Karin Boucke, Robert Witte, Oleg Georgiev, Urs F Greber
Apoptosis and programmed necrosis (necroptosis) determine cell fate, and antagonize infection. Execution of these complementary death pathways involves the formation of receptor-interacting protein kinase 1 (RIPK1) containing complexes. RIPK1 binds to adaptor proteins, such as TRIF (Toll-IL-1 receptor-domain-containing-adaptor-inducing interferon-beta factor), FADD (Fas-associated-protein with death domain), NEMO (NF-κB regulatory subunit IKKγ), SQSTM1 (sequestosome 1/p62), or RIPK3 (receptor-interacting protein kinase 3), which are involved in RNA sensing, NF-κB signaling, autophagosome formation, apoptosis, and necroptosis...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29389566/a-novel-poly-glycine-biosensor-towards-the-detection-of-indigo-carmine-a-voltammetric-study
#2
Jamballi Gangadharappa Gowda Manjunatha
The electrochemical behavior of indigo carmine (IC) at poly (glycine) modified carbon paste electrode (PGMCPE) was investigated by cyclic and differential pulse voltammetry. The oxidation peak of IC was observed in phosphate buffer of pH 6.5. The influence of different pH, scan rate, and concentration were analyzed. The probable reaction mechanism involved in the oxidation of IC was also proposed. Results showed that PGMCPE a remarkable electrocatalytic activity for the oxidation of IC under optimal conditions...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29358709/tumor-derived-exosomes-antagonize-innate-antiviral-immunity
#3
Liang Gao, Lin Wang, Tong Dai, Ke Jin, Zhengkui Zhang, Shuai Wang, Feng Xie, Pengfei Fang, Bing Yang, Huizhe Huang, Hans van Dam, Fangfang Zhou, Long Zhang
Malignancies can compromise innate immunity, but the mechanisms of this are largely unknown. Here we found that, via tumor-derived exosomes (TEXs), cancers were able to transfer activated epidermal growth factor receptor (EGFR) to host macrophages and thereby suppress innate antiviral immunity. Screening of the human kinome identified the kinase MEKK2 in macrophages as an effector of TEX-delivered EGFR that negatively regulated the antiviral immune response. In the context of experimental tumor implantation, MEKK2-deficient mice were more resistant to viral infection than were wild-type mice...
January 22, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29342494/how-does-the-patient-react-after-reading-the-informed-consent-form-of-a-gynecological-surgery-a-qualitative-study
#4
Andrea Cristina Amorim, Luis Guilherme Teixeira Dos Santos, Omero Benedicto Poli-Neto, Luiz Gustavo Oliveira Brito
OBJECTIVE:  To analyze the reaction of women after reading the Informed Consent Form (ICF) before undergoing elective gynecological/urogynecological surgeries. METHODS:  A qualitative study with 53 women was conducted between September 2014 and May 2015. The analysis of the content was conducted after a scripted interview was made in a reserved room and transcribed verbatim. We read the ICF once more in front of the patient, and then she was interviewed according to a script of questions about emotions and reactions that occurred about the procedure and her expectations about the intra- and postoperative period...
January 17, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29314839/interplay-between-hydroxyl-density-and-relaxations-in-poly-vinylbenzyltrimethyl-ammonium-b-poly-methylbutylene-membranes-for-electrochemical-applications
#5
Keti Vezzu', Ashley M Maes, Federico Bertasi, Andrew Motz, Tsung-Han Tsai, E Bryan Coughlin, Andrew M Herring, Vito Di Noto
Anion-exchange membranes (AEMs) consisting of poly (vinyl benzyl trimethyl ammonium)-b-poly (methylbutylene) of three different ion exchange capacities (IECs), 1.14, 1.64, and 2.03 meq g-1, are studied by High-Resolution Thermogravim-etry, Modulated Differential Scanning Calorimetry, Dynamic Mechanical Analysis, and Broadband Electrical Spectroscopy in their OH- form. The thermal stability and transitions are elucidated, showing a low temperature Tg and a higher tempera-ture transition assigned to a disorder-order transition, Tδ, which depends on the IEC of the material...
January 9, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29280358/thermoresponsive-supramolecular-chemotherapy-by-v-shaped-armed-%C3%AE-cyclodextrin-star-polymer-to-overcome-drug-resistance
#6
Xiaoshan Fan, Hongwei Cheng, Xiaoyuan Wang, Enyi Ye, Xian Jun Loh, Yun-Long Wu, Zibiao Li
Pump mediated drug efflux is the key reason to result in the failure of chemotherapy. Herein, a novel star polymer β-CD-v-(PEG-β-PNIPAAm)7 consisting of a β-CD core, grafted with thermo-responsive poly(N-isopropylacrylamide) (PNIPAAm) and biocompatible poly(ethylene glycol) (PEG) in the multiple "V"-shaped arms is designed and further fabricated into supramolecular nanocarriers for drug resistant cancer therapy. The star polymer could encapsulate chemotherapeutics between β-cyclodextrin and anti-cancer drug via inclusion complex (IC)...
December 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29276185/non-viable-lactobacillus-casei-beneficially-modulates-poly-i-c-immune-response-in-co-cultures-of-human-cells
#7
Elisa Vintiñi, Marcela Medina
BACKGROUND: Polyinosinic:polycytidylic acid (Poly-IC) has been used as a viral stimulus to mimic in vivo and in vitro infection induced by some viruses. OBJECTIVE: To determine whether non-viable Lactobacillus casei CRL431 (LcM) can modulate the immune response induced by Poly I:C in co-culture models of peripheral blood mononuclear cells (PBMC) and A549 cells. METHODS: T and NK cell activation was evaluated by flow cytometry and levels of TNF-α, IFN-γ, IL-10, IL-29, and IL-17 by ELISA...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29249322/saponin-quil-a-up-regulates-type-i-interferon-regulated-gene-and-type-i-and-ii-interferon-expressions-which-are-suppressed-by-porcine-reproductive-and-respiratory-syndrome-virus
#8
Wasin Charerntantanakul, Dante Fabros
Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses innate immune response following infection of myeloid antigen-presenting cells. Poor innate immune response results in weak and delayed PRRSV-specific adaptive immunity, and facilitates PRRSV replication, pathogenesis, and persistent infection. Numerous efforts have been made to enhance the effective innate and adaptive immune defenses to PRRSV, however, only a few attempts have so far elicited satisfactory results. The present study aims to evaluate in vitro the potential of saponin quil A to enhance the expression of type I interferon (IFN)-regulated gene, type I and II IFNs, and pro-inflammatory cytokines in PRRSV-inoculated peripheral blood mononuclear cells (PBMC)...
January 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29204085/immune-complex-negatively-regulates-toll-like-receptor-3-triggered-tumour-necrosis-factor-%C3%AE-production-in-b-cells
#9
Li Qian, Wenyan Chen, Shaoqing Wang, Yang Liu, Xiaoqin Jia, Yi Fu, Weijuan Gong, Fang Tian
Inappropriate activation of toll-like receptor 3 (TLR3) has been implicated in the pathogenesis of autoimmune diseases, so the negative regulation of TLR3-triggered immune response has received increasing attention. Nonpathogenic immune complex (IC) has been used as treatment for many inflammatory and autoimmune diseases. However, the role of IC in the regulation of TLR3-triggered immune responses and the underlying mechanisms need to be investigated. In this study we demonstrate that IC or intravenous immunoglobulin (Ig) stimulation of B cells attenuates polyinosinic:polycytidylic acid (poly I:C)-induced CD40 expression; IC, but not Ig, can significantly inhibit poly I:C-induced pro-inflammatory tumour necrosis factor α (TNF-α) production by B cells...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29166644/cylindromatosis-cyld-a-deubiquitinase-attenuates-inflammatory-signaling-pathways-by-activating-toll-like-receptor-3-in-human-mesangial-cells
#10
Tadaatsu Imaizumi, Ryo Hayakari, Shojiro Watanabe, Tomomi Aizawa, Tomoh Matsumiya, Hidemi Yoshida, Kazushi Tsuruga, Shogo Kawaguchi, Hiroshi Tanaka
BACKGROUND/AIMS: Cylindromatosis (CYLD), a deubiquitinase, negatively regulates nuclear factor-κB in various cells. However, its potential roles in glomerular inflammation remain unclear. Because the activation of the Toll-like receptor 3 (TLR3)/type I interferon (IFN) pathways plays a pivotal role in chronic kidney diseases (CKD), we examined the role of CYLD in the TLR3 signaling in cultured human mesangial cells (MCs). METHODS: We stimulated CYLD-silenced MCs with polyinosinic-polycytidylic acid (poly IC), a synthetic analogue of dsRNA, and studied representative TLR3/IFN-β pathways (i...
November 22, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29130803/steroid-sparing-effect-of-sublingual-immunotherapy-real-life-study-in-mono-polisensitized-children-with-asthma
#11
Nerin Nadir Bahceciler, Nilufer Galip, Arzu Babayigit
AIM: Steroid-sparing effect of sublingual immunotherapy (SLIT) in mono/polisensitized asthmatic children were evaluated. MATERIALS AND METHODS:  Children undergoing allergen-specific SLIT between 2010 and 2014 were included. Asthma control and usage/dose of inhaled corticosteroid (ICS) in the previous year was determined. Asthma control without ICS need ≥6 months was defined as 'ICS avoidance'. RESULTS:  90 children (mean ± SD age 8...
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29128386/a-pilot-study-of-endoscopically-inserted-biodegradable-biliary-stents-in-the-treatment-of-benign-biliary-strictures-and-cystic-duct-leaks
#12
Antti Siiki, Irina Rinta-Kiikka, Juhani Sand, Johanna Laukkarinen
BACKGROUND AND AIMS: Self-expanding biodegradable biliary stents (BDBSs) have recently become available for use in endoscopic retrograde cholangiography (ERC). The aim was to evaluate the effectiveness and safety of novel BDBS in iatrogenic cystic duct leaks and benign biliary strictures (BBSs). MATERIALS AND METHODS: Patients providing informed consent were recruited for the prospective study. Braided self-expanding poly-dioxanone BDBSs were inserted in ERC during the period 2012 to 2016...
November 8, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29127663/poly-i-c-priming-exacerbates-cecal-ligation-and-puncture-induced-polymicrobial-sepsis-in-mice
#13
Deepika Sharma, Ankit Malik, Nandakumar Packiriswamy, Michael D Steury, Narayanan Parameswaran
Sepsis continues to be a major healthcare issue with one of the highest mortality rates in intensive care units. Toll-like receptors are pattern recognition receptors that are intricately involved in the pathogenesis of sepsis. TLR3 is a major receptor for double-stranded RNA and is largely associated with immunity to viral infection. In this study, we examined the role of TLR3 priming in the immunopathology of sepsis using cecal-ligation and puncture (CLP) model of sepsis in mice. Mice injected with vehicle or poly(I:C) were subjected to sham or CLP surgery and various parameters of sepsis, including mortality, inflammation, and bacterial clearance were assessed...
November 10, 2017: Inflammation
https://www.readbyqxmd.com/read/29111062/plasma-treated-poly-ethylene-oxide-nanofibers-containing-tea-tree-oil-beta-cyclodextrin-inclusion-complex-for-antibacterial-packaging
#14
Haiying Cui, Mei Bai, Lin Lin
This work describes the effect of cold nitrogen plasma to enhance the antibacterial activity of poly(ethylene oxide) (PEO) nanofibers containing antibacterial agent. Beta-cyclodextrin (β-CD) and tea tree oil (TTO) were used as a host-guest to form water-soluble inclusion complex. The encapsulation efficiency of TTO in inclusion complex could reach 73.23% at 60°C. As antibacterial agent, the inclusion complex was encapsulated into PEO matrix by electrospun. After plasma treatment, the release efficiency of antibacterial agent from PEO nanofibers was improved...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29073183/adjuvants-and-the-vaccine-response-to-the-ds-cav1-stabilized-fusion-glycoprotein-of-respiratory-syncytial-virus
#15
Mallika Sastry, Baoshan Zhang, Man Chen, M Gordon Joyce, Wing-Pui Kong, Gwo-Yu Chuang, Kiyoon Ko, Azad Kumar, Chiara Silacci, Michelle Thom, Andres M Salazar, Davide Corti, Antonio Lanzavecchia, Geraldine Taylor, John R Mascola, Barney S Graham, Peter D Kwong
Appropriate adjuvant selection may be essential to optimize the potency and to tailor the immune response of subunit vaccines. To induce protective responses against respiratory syncytial virus (RSV)-a highly prevalent childhood pathogen without a licensed vaccine-we previously engineered a pre-fusion-stabilized trimeric RSV F (pre-F) "DS-Cav1" immunogen, which induced high titer RSV-neutralizing antibodies, in mice and non-human primates, when formulated with adjuvants Poly (I:C) and Poly (IC:LC), respectively...
2017: PloS One
https://www.readbyqxmd.com/read/29070776/ccl5-is-induced-by-tlr-3-signaling-in-hucct1-human-biliary-epithelial-cells-possible-involvement-in-the-pathogenesis-of-biliary-atresia
#16
Taku Shimada, Tadaatsu Imaizumi, Kyogo Shirai, Tetsuya Tatsuta, Toshiro Kimura, Ryo Hayakari, Hidemi Yoshida, Tomoh Matsumiya, Hiroshi Kijima, Hiroki Mizukami, Kenichi Hakamada
Biliary atresia (BA) is a disease of the newborn that is characterized by progressive, inflammatory and sclerosing cholangiopathy. Innate immune responses to viral components are thought to be involved in the pathogenesis of BA. It is also reported that some chemokines, such as CCL5, are possibly involved in the pathogenesis of experimental animal model of BA. We treated human biliary epithelial HuCCT1 cells with polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA (dsRNA) which mimics viral RNA, and analyzed the CCL5 expression by quantitative reverse transcription-PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA)...
2017: Biomedical Research
https://www.readbyqxmd.com/read/29066896/aminated-nanomicelles-as-a-designer-vaccine-adjuvant-to-trigger-inflammasomes-and-multiple-arms-of-the-innate-immune-response-in-lymph-nodes
#17
Chanyoung Song, Hathaichanok Phuengkham, Sun-Young Kim, Min Sang Lee, Ji Hoon Jeong, Sung Jae Shin, Yong Taik Lim
In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent carboxyl groups in poly-(γ-glutamic acid) (γ-PGA) nanomicelles, the size was reduced for rapid entry into lymphatic vessels, and the immunologically inert nanomicelles were turned into potential activators of inflammasomes. Aminated γ-PGA nanomicelles (aPNMs) induced NLRP3 inflammasome activation and the subsequent release of proinflammatory IL-1β...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29050282/effective-antitumor-peptide-vaccines-can-induce-severe-autoimmune-pathology
#18
Hussein Sultan, Jimena Trillo-Tinoco, Paulo Rodriguez, Esteban Celis
Immunotherapy has shown a tremendous success in treating cancer. Unfortunately, this success is frequently associated with severe autoimmune pathology. In this study, we used the transgenic RIP-gp mouse model to assess the antitumor therapeutic benefit of peptide vaccination while evaluating the possible associated autoimmune pathology. We report that palmitoylated gp33-41 peptide and poly-IC adjuvant vaccine (BiVax) generated ∼ 5-10 % of antigen specific T cell responses in wild type and supposedly immune tolerant RIP-gp mice...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28882807/atlantic-salmon-endothelial-cells-from-the-heart-were-more-susceptible-than-fibroblasts-from-the-bulbus-arteriosus-to-four-rna-viruses-but-protected-from-two-viruses-by-dsrna-pretreatment
#19
Phuc H Pham, Winnie W L Tong, Ehab Misk, Ginny Jones, John S Lumsden, Niels C Bols
Heart diseases caused by viruses are major causes of Atlantic salmon aquaculture loss. Two Atlantic salmon cardiovascular cell lines, an endothelial cell line (ASHe) from the heart and a fibroblast cell line (BAASf) from the bulbus arteriosus, were evaluated for their response to four fish viruses, CSV, IPNV, VHSV IVa and VHSV IVb, and the innate immune agonist, double-stranded RNA mimic poly IC. All four viruses caused cytopathic effects in ASHe and BAASf. However, ASHe was more susceptible to all four viruses than BAASf...
September 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28853490/interleukin-26-production-in-human-primary-bronchial-epithelial-cells-in-response-to-viral-stimulation-modulation-by-th17-cytokines
#20
Karlhans Fru Che, Riitta Kaarteenaho, Elisa Lappi-Blanco, Bettina Levänen, Jitong Sun, Åsa Wheelock, Lena Palmberg, C Magnus Sköld, Anders Lindén
Interleukin (IL)-26 is abundant in human airways and this cytokine is involved in the local immune response to a bacterial stimulus in vivo. Specifically, local exposure to the toll-like receptor (TLR) 4 agonist endotoxin does increase IL-26 in human airways and this cytokine potentiates chemotactic responses in human neutrophils. In addition to T-helper (Th) 17 cells, alveolar macrophages can produce IL-26, but it remains unknown whether this cytokine can also be produced in the airway mucosa per se in response to a viral stimulus...
August 29, 2017: Molecular Medicine
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