keyword
https://read.qxmd.com/read/36678577/-68-ga-hbed-cc-wl-12-pet-in-diagnosing-and-differentiating-pancreatic-cancers-in-murine-models
#21
JOURNAL ARTICLE
Qiying Xiang, Danni Li, Chao Cheng, Kai Xu, Changjing Zuo
Positron emission tomography (PET) has been proven as an important technology to detect the expression of programmed death ligand 1 (PD-L1) non-invasively and in real time. As a PD-L1 inhibitor, small peptide WL12 has shown great potential in serving as a targeting molecule to guide PD-L1 blockade therapy in clinic. In this study, WL12 was modified with HBED-CC to label 68 Ga in a modified procedure, and the biologic properties were evaluated in vitro and in vivo. 68 Ga-HBED-CC-WL12 showed good stability in saline and can specifically target PD-L1-positive cells U87MG and PANC02...
January 5, 2023: Pharmaceuticals
https://read.qxmd.com/read/36658300/the-immune-microenviroment-in-somatotropinomas-from-biology-to-personalized-and-target-therapy
#22
REVIEW
Sabrina Chiloiro, Laura De Marinis
Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pituitary tumors...
April 2023: Reviews in Endocrine & Metabolic Disorders
https://read.qxmd.com/read/36595192/sars-cov2-entry-factors-are-expressed-in-primary-human-glioblastoma-and-recapitulated-in-cerebral-organoid-models
#23
JOURNAL ARTICLE
Paola Suarez-Meade, Fumihiro Watanabe, Henry Ruiz-Garcia, Seamus B Rafferty, Diogo Moniz-Garcia, Paula V Schiapparelli, Mark E Jentoft, Jaime Imitola, Alfredo Quinones-Hinojosa
PURPOSE: Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults with a median overall survival of only 14.6 months despite aggressive treatment. While immunotherapy has been successful in other cancers, its benefit has been proven elusive in GBM, mainly due to a markedly immunosuppressive tumor microenvironment. SARS-CoV-2 has been associated with the development of a pronounced central nervous system (CNS) inflammatory response when infecting different cells including astrocytes, endothelial cells, and microglia...
January 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/36580009/nanotherapy-new-approach-for-impeding-hepatic-cancer-microenvironment-via-targeting-multiple-molecular-pathways
#24
JOURNAL ARTICLE
Ahmed A Abd-Rabou, Hanaa H Ahmed, Safaa H Mohamed, Soheir E Kotob, Mohamed S Kishta
OBJECTIVE: Hepatocellular carcinoma (HCC) microenvironment has been recognized as a key contributor for cancer progression, metastasis, and drug resistance. The crosstalk between tumor cells, the vascular endothelial growth factor (VEGF), and the chemokine (C-C motif) ligand 2 (CCL2) signaling networks mediates immunoinhibitory impact and facilitates tumor angiogenesis. The current investigation aimed at exploring the potent anti-cancer activity of the newly designed nano-based anti-cancer therapy comprising anti-VEGF drug, avastin (AV), and CCR2 antagonist (CR) to counteract HCC and tracking its mode of action in vivo...
December 1, 2022: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/36505481/crosstalk-of-angiogenesis-related-subtypes-establishment-of-a-prognostic-signature-and-immune-infiltration-characteristics-in-colorectal-adenocarcinoma
#25
JOURNAL ARTICLE
Guoliang Cui, Jinhui Liu, Manli Wang, Kinyu Shon, Can Wang, Fei Wei, Zhiguang Sun
BACKGROUND: Colorectal adenocarcinoma (COAD) is one of the most common malignancies and angiogenesis is vital to the development of cancer. Here, we explored the roles of angiogenesis-related genes (ARGs) that affect the prognosis of COAD and constructed risk models to assess patient prognosis, immune characteristics, and treatment outcomes. METHODS: We comprehensively characterized the transcriptional and genetic modifications of 48 ARGs in COAD and evaluated the expression patterns...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36437939/erbb2-as-a-prognostic-biomarker-correlates-with-immune-infiltrates-in-papillary-thyroid-cancer
#26
JOURNAL ARTICLE
Yuchen Jin, Xian Qiu, Ziyan He, JunYao Wang, Ri Sa, Libo Chen
Epidermal growth factor receptor 2 ( ERBB2 ) is commonly over-expressed in advanced or metastatic tissues of papillary thyroid cancer (PTC) with poor prognosis, while it remains unknown whether ERBB2 plays a role in the progression of PTC. Thus, we analyzed the data derived from online repositories, including TCGA, KEGG, GO, GeneMANIA, and STRING, to explore the relationship between ERBB2 expression and prognosis, tumor phenotypes of interest, and immune infiltrates in PTC. Compared to normal thyroid tissue, ERBB2 was up-regulated in PTC samples ( p < 0...
2022: Frontiers in Genetics
https://read.qxmd.com/read/36245826/the-immune-landscape-of-hepatocellular-carcinoma-where-we-are
#27
REVIEW
Maciej Gryziak, Krzysztof Wozniak, Leszek Kraj, Letycja Rog, Rafal Stec
Hepatocellular carcinoma (HCC) is one of the most common types of cancer diagnosed worldwide. After a decade of stagnation, several novel compounds have recently been shown to be effective in the treatment of HCC. Since immunotherapy is associated with important clinical benefits in some, but not all patients, it is essential to identify reliable predictive biomarkers. As the complex interplay between hepatocytes and immune cells is highly dependent on the tumor microenvironment, the tumor microenviroment has been suggested to be an important factor associated with the response to therapy and is currently being extensively investigated...
November 2022: Oncology Letters
https://read.qxmd.com/read/36199581/regulatory-pattern-of-abnormal-promoter-cpg-island-methylation-in-the-glioblastoma-multiforme-classification
#28
JOURNAL ARTICLE
Rendong Wang, Lei Zhao, Shijia Wang, Xiaoxiao Zhao, Chuanyu Liang, Pei Wang, Dongguo Li
Glioblastoma (GBM) is characterized by extensive genetic and phenotypic heterogeneity. However, it remains unexplored primarily how CpG island methylation abnormalities in promoter mediate glioblastoma typing. First, we presented a multi-omics scale map between glioblastoma sample clusters constructed based on promoter CpG island (PCGI) methylation-driven genes, using datasets including methylation profiles, expression profiles, and single-cell sequencing data from multiple highly annotated public clinical cohorts...
2022: Frontiers in Genetics
https://read.qxmd.com/read/36186479/a-novel-necroptosis-related-gene-signature-associated-with-immune-landscape-for-predicting-the-prognosis-of-papillary-thyroid-cancer
#29
JOURNAL ARTICLE
Zhiyuan Wang, Pu Wu, Jinyuan Shi, Xiaoyu Ji, Liang He, Wenwu Dong, Zhihong Wang, Hao Zhang, Wei Sun
Background: Necroptosis, a type of programmed cell death, has been implicated in a variety of cancer-related biological processes. However, the roles of necroptosis-related genes in thyroid cancer yet remain unknown. Methods: A necroptosis-related gene signature was constructed using the least absolute shrinkage and selection operator (LASSO) regression analysis and Cox regression analysis. The predictive value of the prognostic signature was validated in an internal cohort. Additionally, the single-sample gene set enrichment analysis (ssGSEA) was used to examine the relationships between necroptosis and immune cells, immunological functions, and immune checkpoints...
2022: Frontiers in Genetics
https://read.qxmd.com/read/36077865/covid-19-vs-cancer-immunosurveillance-a-game-of-thrones-within-an-inflamed-microenviroment
#30
REVIEW
Ioannis Liapis, Stavroula Baritaki
The COVID-19 pandemic accounts for more than 500 million confirmed infections and over 6 million deaths worldwide in the last 2 years. SARS-CoV-2 causes a highly complex form of inflammation that affects the human organism both acutely and chronically. In the same line, cancer as an inflammation-induced and immune-editing disease appears to cross-react with immune system at different levels including early interactions during carcinogenesis and later cross-talks within the tumor microenvironment. With all that in mind, a reasonable question one might address is whether the SARS-CoV-2 infection and the derived "long lasting inflammatory status" that is frequently observed in patients, might affect the cancer immunosurveillance mechanisms and consequently their risk of developing cancer, as well as the tumor and immune cell behaviors within the inflamed microenvironment...
September 5, 2022: Cancers
https://read.qxmd.com/read/36003146/association-of-aging-related-genes-with-prognosis-and-immune-infiltration-in-pancreatic-adenocarcinoma
#31
JOURNAL ARTICLE
Shengbai Xue, Weiyu Ge, Kexuan Wang, Tiebo Mao, Xiaofei Zhang, Haiyan Xu, Yongchao Wang, Jiayu Yao, Shumin Li, Ming Yue, Jingyu Ma, Yanling Wang, Daiyuan Shentu, Jiujie Cui, Liwei Wang
Pancreatic adenocarcinoma (PAAD) is one of the deadliest malignancies. Aging is described as the degeneration of physiological function, which is complexly correlated with cancer. It is significant to explore the influences of aging-related genes (ARGs) on PAAD. Based on The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) datasets, we used univariate Cox regression analysis and acquired eight differentially expressed ARGs with prognostic values. Two molecular subtypes were identified based on these ARGs to depict PAAD patients' overall survival (OS) and immune microenvironments preliminarily...
2022: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/35996712/lymphoplasmacyte-rich-meningioma-with-hematologic-signs-and-pd-l1-over-expression
#32
JOURNAL ARTICLE
Gabriele Gaggero, Michela Campora, Davide Taietti, Giannamaria Cerruti, Enrico Lo Bue, Monica Truffelli, Marco Ceraudo, Pietro Fiaschi
Lymphoplasmacyte-rich meningioma (LPRM) is one of the rarest variants of grade I meningiomas. It can be clinically associated with prominent peripheral blood abnormalities, anemia, and/or various gammopathy, which usually disappear after surgical removal of the tumor. We document a case of right frontal LPRM in a 72-year-old male who presented general cognitive decadence. The patient suffered from mild anemia. The LPRM is a rare variant of meningioma, with only a few cases globally reported in the literature...
2022: Autopsy & Case Reports
https://read.qxmd.com/read/35992269/characterizing-the-role-of-slc3a2-in-the-molecular-landscape-and-immune-microenvironment-across-human-tumors
#33
JOURNAL ARTICLE
Jiajun He, Dong Liu, Mei Liu, Rong Tang, Dongqing Zhang
Background: Inducing ferroptosis in human tumors has become a potential strategy to improve the prognosis of patients, even in those with chemotherapeutic resistance. The xCT complex is a major target for ferroptosis induction, constituted by SLC7A11 and SLC3A2. The role of SLC7A11 in cancer has been widely studied in recent years. However, related research studies for its partner SLC3A2 are still rare. Methods: Bulk transcriptome, single-cell sequencing, and immunohistochemical staining were analyzed to explore the expression distribution of SLC3A2...
2022: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/35940258/ampk%C3%AE-2-hnf4a-boris-glut4-pathway-promotes-hepatocellular-carcinoma-cell-invasion-and-metastasis-in-low-glucose-microenviroment
#34
JOURNAL ARTICLE
Yuan Huang, Longjun Xian, Zhongjian Liu, Ling Wei, Lu Qin, Yimei Xiong, Lei Hu, Siqi Zhou, Qiang Fu, Bo Li, Yang Qin
Increasing evidence has revealed that the invasion and metastasis of HCC are intimately related to the low-glucose microenvironment, but the intrinsic regulatory mechanism remains unclear. It has been well documented that AMPK regulates the transcriptional expression of GLUT4 and its catalytic subunit AMPKα2 can negatively regulate the downstream target molecule HNF4A. Meanwhile, BORIS (Brother of the Regulator of Imprinted Sites) is able to modulate the Warburg effect by regulating the splicing of pyruvate kinase M2 (PKM2), a critical enzyme in glycolysis...
August 5, 2022: Biochemical Pharmacology
https://read.qxmd.com/read/35936362/bioinformatics-analysis-revealing-the-correlation-between-nf-%C3%AE%C2%BA-b-signaling-pathway-and-immune-infiltration-in-gastric-cancer
#35
JOURNAL ARTICLE
Qiuxiang Chen, Xiaojing Du, Pengcheng Ruan, Yumei Ye, Jin Zheng, Sunkuan Hu
Although the emerging of immunotherapy conferred a new landscape of gastric cancer (GC) treatment, its response rate was of significant individual differences. Insight into GC immune microenviroment may contribute to breaking the dilemma. To this end, the enrichment score of NF- κ B signaling pathway was calculated in each GC sample from The Cancer Genome Atlas (TCGA) via ssGSEA algorithm, and its association with immune infiltration was estimated. Based on NF- κ B-related genes, a risk score was established and its involvement in immune infiltration, tumor mutational burden (TMB), and N6-methyladenosine (M6A) modification was analyzed in GC...
2022: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/35857405/anlotinib-combined-with-toripalimab-as-second-line-therapy-for-advanced-relapsed-gastric-or-gastroesophageal-junction-carcinoma
#36
JOURNAL ARTICLE
Man Jiang, Chuantao Zhang, Yabin Hu, Tianjun Li, Guangjie Yang, Guanqun Wang, Jingjuan Zhu, Changfeng Shao, Helei Hou, Na Zhou, Kewei Liu, Xiaochun Zhang
Our study aimed to explore the efficacy and safety of anlotinib-toripalimab combination therapy as a second-line treatment for advanced relapsed gastric or gastroesophageal junction carcinoma (GC/GEJC). In this single arm, single-center extension clinical trial, patients with advanced relapsed GC/GEJC received toripalimab (240 mg, intravenously over 60 minutes, once every 2 weeks) plus anlotinib (12 mg/day, orally, 2 weeks on and 1 week off, every 3 weeks) as second-line therapy. There were 29 patients who achieved partial response, and the ORR was 32...
July 20, 2022: Oncologist
https://read.qxmd.com/read/35802605/quantitative-proteomic-landscapes-of-primary-and-recurrent-glioblastoma-reveal-a-protumorigeneic-role-for-fbxo2-dependent-glioma-microenvironment-interactions
#37
JOURNAL ARTICLE
Marcel Buehler, Xiao Yi, Weigang Ge, Peter Blattmann, Elisabeth Rushing, Guido Reifenberger, Joerg Felsberg, Charles Yeh, Jacob E Corn, Luca Regli, Junyi Zhang, Ann Cloos, Vidhya M Ravi, Benedikt Wiestler, Dieter Henrik Heiland, Ruedi Aebersold, Michael Weller, Tiannan Guo, Tobias Weiss
BACKGROUND: Recent efforts have described the evolution of glioblastoma from initial diagnosis to post-treatment recurrence on a genomic and transcriptomic level. However, the evolution of the proteomic landscape is largely unknown. METHODS: Sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) was used to characterize the quantitative proteomes of two independent cohorts of paired newly diagnosed and recurrent glioblastomas...
February 14, 2023: Neuro-oncology
https://read.qxmd.com/read/35600343/editorial-metabolism-meets-function-the-multifaced-role-of-metabolism-in-cancer
#38
EDITORIAL
Isabella Giacomini, Monica Montopoli
No abstract text is available yet for this article.
2022: Frontiers in Oncology
https://read.qxmd.com/read/35547808/pyroptosis-related-gene-signature-predicts-prognosis-and-indicates-immune-microenvironment-infiltration-in-glioma
#39
JOURNAL ARTICLE
Yulian Zhang, Chuanpeng Zhang, Yanbo Yang, Guohui Wang, Zai Wang, Jiang Liu, Li Zhang, Yanbing Yu
Objective: Gliomas are the most common primary tumors in the central nervous system with a bad prognosis. Pyroptosis, an inflammatory form of regulated cell death, plays a vital role in the progression and occurrence of tumors. However, the value of pyroptosis related genes (PRGs) in glioma remains poorly understood. This study aims to construct a PRGs signature risk model and explore the correlation with clinical characteristics, prognosis, tumor microenviroment (TME), and immune checkpoints. Methods: RNA sequencing profiles and the relevant clinical data were obtained from the Chinese Glioma Genome Atlas (CGGA), the Cancer Genome Atlas (TCGA), the Repository of Molecular Brain Neoplasia Data (REMBRANDT), and the Genotype-Tissue Expression Project (GTEx-Brain)...
2022: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/35485488/-lipidomic-markers-of-tumor-progress-in-breast-cancer-patients
#40
JOURNAL ARTICLE
A O Tokareva, N L Starodubtseva, V V Chagovets, V V Rodionov, V V Kometova, K S Chingin, V E Frankevich
Research of cancer progression mechanisms and their impact on metabolism of tumor cells and tumor microenvironment cells is an important element in drug development for cancer target therapy. In this study, changes in tumor tissue and margin tissue lipid profiles, were associated with the following clinical and morphological characteristics: tumor size, cancer stage, multifocalite, tumor grade, number of lymph node metastasis, Nottingham prognostic index, total malignancy score, level of Ki67 protein. Lipid profiling was performed by reverse-phase chromato-mass spectrometry analysis of lipid tissue extract with lipid identification by characteristic fragments...
April 2022: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
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