Patricia González-Callejo, Petra Gener, Zamira V Díaz-Riascos, Sefora Conti, Patricia Cámara-Sánchez, Roger Riera, Sandra Mancilla, Miguel García-Gabilondo, Vicente Peg, Diego Arango, Anna Rosell, Anna Labernadie, Xavier Trepat, Lorenzo Albertazzi, Simó Schwartz, Joaquin Seras-Franzoso, Ibane Abasolo
Tumor secreted extracellular vesicles (EVs) are potent intercellular signaling platforms. They are responsible for the accommodation of the pre-metastatic niche (PMN) to support cancer cell engraftment and metastatic growth. However, complex cancer cell composition within the tumor increases also the heterogeneity among cancer secreted EVs subsets, a functional diversity that has been poorly explored. This phenomenon is particularly relevant in highly plastic and heterogenous Triple Negative Breast Cancer (TNBC), in which a significant representation of malignant cancer stem cells (CSCs) is displayed...
January 27, 2023: International Journal of Cancer. Journal International du Cancer