keyword
https://read.qxmd.com/read/38450975/targeting-neutrophils-mechanism-and-advances-in-cancer-therapy
#1
REVIEW
Shuaixi Yang, Jiachi Jia, Fuqi Wang, Yuhang Wang, Yingshuai Fang, Yabing Yang, Quanbo Zhou, Weitang Yuan, Zhilei Bian
BACKGROUND: Cancer is a thorny problem which cannot be conquered by mankind at present and recent researchers have put their focus on tumor microenviroment. Neutrophils, the prominent leukocytes in peripheral blood that accumulate in tumours, serves as frontline cells in response to tumour progression owing to the rapid development of micro biotechnology. Hence, targeted therapy with these neutrophils has made targeting treatment a promising field in cancer therapy. MAIN BODY: We broadly summarise some studies on the phenotypes and functions of tumour-associated neutrophils as well as the unique web-like products of neutrophils that play a role in cancer progression-neutrophil extracellular traps-and the interactions between neutrophils and the tumour microenvironment...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38332160/a-novel-anoikis-related-gene-signature-identifies-lypd1-as-a-novel-therapy-target-for-bladder-cancer
#2
JOURNAL ARTICLE
Zhen Song, Shikai Gui, Shuaiyun Xiao, Xuepeng Rao, Na Cong, Huanhuan Deng, Zhaojun Yu, Tao Zeng
Bladder cancer (BLCA) is a malignant tumor associated with unfavorable outcomes. Studies suggest that anoikis plays a crucial role in tumor progression and cancer cell metastasis. However, its specific role in bladder cancer remains poorly understood. Our objective was to identify anoikis-related genes (ARGs) and subsequently construct a risk model to assess their potential for predicting the prognosis of bladder cancer.The transcriptome data and clinical data of BLCA patients were sourced from The Cancer Genome Atlas and GEO database...
February 8, 2024: Scientific Reports
https://read.qxmd.com/read/38099947/global-stability-and-parameter-analysis-reinforce-therapeutic-targets-of-pd-l1-pd-1-and-mdscs-for-glioblastoma
#3
JOURNAL ARTICLE
Hannah G Anderson, Gregory P Takacs, Duane C Harris, Yang Kuang, Jeffrey K Harrison, Tracy L Stepien
Glioblastoma (GBM) is an aggressive primary brain cancer that currently has minimally effective treatments. Like other cancers, immunosuppression by the PD-L1-PD-1 immune checkpoint complex is a prominent axis by which glioma cells evade the immune system. Myeloid-derived suppressor cells (MDSCs), which are recruited to the glioma microenviroment, also contribute to the immunosuppressed GBM microenvironment by suppressing T cell functions. In this paper, we propose a GBM-specific tumor-immune ordinary differential equations model of glioma cells, T cells, and MDSCs to provide theoretical insights into the interactions between these cells...
December 15, 2023: Journal of Mathematical Biology
https://read.qxmd.com/read/38059310/immune-checkpoint-inhibitors-in-hepatocellular-carcinoma-a%C3%A2-review-of-current-clinical-trials
#4
REVIEW
Adriana C Gamboa, David A Kooby, Shishir K Maithel, T Clark Gamblin
Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis due to advanced disease presentation or recurrence despite curative-intent resection. Since the approval of sorafenib in 2007, few systemic therapies offered a significant improvement in treatment outcomes. Over the last 3 years, however, rapid advancements in the field of immunotherapy have led to approval of checkpoint inhibitors in 2020 for use in advanced HCC. Since then, a few other clinical trials have shown promising results in the adjuvant and neoadjuvant setting...
January 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38059123/tumor-microenviroment-responsive-self-assembly-of-barium-titanate-nanoparticles-with-enhanced-piezoelectric-catalysis-capabilities-for-efficient-tumor-therapy
#5
JOURNAL ARTICLE
Zhuo Xiang, Lingling Xu, Yizhu Shan, Xi Cui, Bojing Shi, Yuan Xi, Panxing Ren, Xuemei Zheng, Chaochao Zhao, Dan Luo, Zhou Li
Catalytic therapy based on piezoelectric nanoparticles has become one of the effective strategies to eliminate tumors. However, it is still a challenge to improve the tumor delivery efficiency of piezoelectric nanoparticles, so that they can penetrate normal tissues while specifically aggregating at tumor sites and subsequently generating large amounts of reactive oxygen species (ROS) to achieve precise and efficient tumor clearance. In the present study, we successfully fabricated tumor microenvironment-responsive assembled barium titanate nanoparticles (tma-BTO NPs): in the neutral pH environment of normal tissues, tma-BTO NPs were monodisperse and possessed the ability to cross the intercellular space; whereas, the acidic environment of the tumor triggered the self-assembly of tma-BTO NPs to form submicron-scale aggregates, and deposited in the tumor microenvironment...
March 2024: Bioactive Materials
https://read.qxmd.com/read/37941560/corrigendum-c-reactive-protein-is-an-indicator-of-the-immunosuppressive-microenvironment-fostered-by-myeloid-cells-in-hepatocellular-carcinoma
#6
Yongchun Wang, Zhixiong Li, Zhijie Huang, Xingjuan Yu, Limin Zheng, Jing Xu
[This corrects the article DOI: 10.3389/fonc.2021.774823.].
2023: Frontiers in Oncology
https://read.qxmd.com/read/37795088/editorial-exploring-oncolytic-virus-mediated-changes-in-immune-microenvironment-and-immune-cells-in-solid-tumors
#7
EDITORIAL
Hongwei Zhang
No abstract text is available yet for this article.
2023: Frontiers in Immunology
https://read.qxmd.com/read/37697300/portraying-the-dark-side-of-endogenous-ifn-%C3%AE-for-promoting-cancer-progression-and-immunoevasion-in-pan-cancer
#8
JOURNAL ARTICLE
Zhen Zhen Wang, Xiao Ling Wen, Na Wang, Xu Hua Li, Yu Guo, Xu Zhu, Shu Heng Fu, Fei Fan Xiong, Jin Li, Limei Wang, Xiao Ling Gao, Hong Jiu Wang
BACKGROUND: IFN-λ has been shown to have a dual function in cancer, with its tumor-suppressive roles being well-established. However, the potential existence of a negative ''tumor-promoting'' effect of endogenous IFN-λ is still not fully understood. METHODS: We conducted a comprehensive review and analysis of the perturbation of IFN-λ genes across various cancer types. Correlation coefficients were utilized to examine the relationship between endogenous IFN-λ expression and clinical factors, immune cell infiltration, tumor microenvironment, and response to immunotherapy...
September 11, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37608898/the-effect-of-liver-disease-on-hepatic-microenvironment-and-implications-for-immune-therapy
#9
REVIEW
Zachary J Brown, Samantha M Ruff, Timothy M Pawlik
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the fourth leading cause of cancer-related death worldwide. HCC often occurs in the setting of chronic liver disease or cirrhosis. Recent evidence has highlighted the importance of the immune microenvironment in the development and progression of HCC, as well as its role in the potential response to therapy. Liver disease such as viral hepatitis, alcohol induced liver disease, and non-alcoholic fatty liver disease is a major risk factor for the development of HCC and has been demonstrated to alter the immune microenvironment...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37505479/a-population-of-tumor-infiltrating-cd4-t-cells-co-expressing-cd38-and-cd39-is-associated-with-checkpoint-inhibitor-resistance
#10
JOURNAL ARTICLE
Ankita Mitra, Brian Thompson, Ann Strange, Carol M Amato, Melinda Vassallo, Igor Dolgalev, Jonathan Hester-McCullough, Tomoaki Muramatsu, Diana Kimono, Amrutesh S Puranik, Jeffrey S Weber, David Woods
PURPOSE: We previously showed that elevated frequencies of peripheral blood CD3+CD4+CD127-GARP-CD38+CD39+ T-cells was associated with checkpoint immunotherapy resistance in metastatic melanoma patients. In the present study we sought to further investigate this population of ectoenzyme expressing T-cells (Teee). Expeirmental Design: Teee derived from the peripheral blood of metastatic melanoma patients were evaluated by bulk RNA-seq and flow cytometry. The presence of Teee in the tumor microenviroment was assessed using publically available single-cell RNA-seq datasets of melanoma, lung, and bladder cancer along with multispectral immunofluorescent imaging of melanoma patient FFPE specimens...
July 28, 2023: Clinical Cancer Research
https://read.qxmd.com/read/37372349/microsatellite-instability-and-immune-response-from-microenvironment-features-to-therapeutic-actionability-lessons-from-colorectal-cancer
#11
REVIEW
Luana Greco, Federica Rubbino, Arianna Dal Buono, Luigi Laghi
Microsatellite instability (MSI) can be found in 15-20% of all colorectal cancers (CRC) and is the key feature of a defective DNA mismatch repair (MMR) system. Currently, MSI has been established as a unique and pivotal biomarker in the diagnosis, prognosis, and treatment of CRC. MSI tumors display a strong lymphocytic activation and a shift toward a tumoral microenvironment restraining metastatic potential and ensuing in a high responsiveness to immunotherapy of MSI CRC. Indeed, neoplastic cells with an MMR defect overexpress several immune checkpoint proteins, such as programmed death-1 (PD-1) and programmed death-ligand 1(PD-L1), that can be pharmacologically targeted, allowing for the revival the cytotoxic immune response toward the tumor...
May 27, 2023: Genes
https://read.qxmd.com/read/37365634/rewiring-innate-and-adaptive-immunity-with-tlr9-agonist-to-treat-osteosarcoma
#12
JOURNAL ARTICLE
Caterina Cascini, Chiara Ratti, Laura Botti, Beatrice Parma, Valeria Cancila, Adriana Salvaggio, Cristina Meazza, Claudio Tripodo, Mario P Colombo, Claudia Chiodoni
BACKGROUND: Osteosarcoma (OS) is the most common primary bone tumor in children and adolescent. Surgery and multidrug chemotherapy are the standard of treatment achieving 60-70% of event-free survival for localized disease at diagnosis. However, for metastatic disease, the prognosis is dismal. Exploiting immune system activation in the setting of such unfavorable mesenchymal tumors represents a new therapeutic challenge. METHODS: In immune competent OS mouse models bearing two contralateral lesions, we tested the efficacy of intralesional administration of a TLR9 agonist against the treated and not treated contralateral lesion evaluating abscopal effect...
June 26, 2023: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/37354638/connexin43-is-associated-with-the-progression-of-clear-cell-renal-carcinoma-and-is-regulated-by-tangeretin-to-sygergize-with-tyrosine-kinase-inhibitors
#13
JOURNAL ARTICLE
Yongchang Lai, Weizhou Wu, Xiongfa Liang, Fangling Zhong, Lingyue An, Zhenglin Chang, Chao Cai, Zhaohui He, Wenqi Wu
BACKGROUND: The roles of Connexin43 (Cx43) in clear cell renal cell carcinoma (ccRCC) microenviroment remains to be poorly defined. METHODS: The expression profile, prognosis and immune analysis of Cx43 in various cancers, particularly in ccRCC were performed using TCGA database, and various biological function assays were applied to explore the physiological role of Cx43 and tangeretin in ccRCC. Western blot were applied to examine the protein expression and Kunming mice were used to evaluate preliminary safety or anti-tumor activity of tangeretin and sunitinib...
June 22, 2023: Translational Oncology
https://read.qxmd.com/read/37292799/global-stability-and-parameter-analysis-reinforce-therapeutic-targets-of-pd-l1-pd-1-and-mdscs-for-glioblastoma
#14
Hannah G Anderson, Gregory P Takacs, Duane C Harris, Yang Kuang, Jeffrey K Harrison, Tracy L Stepien
Glioblastoma (GBM) is an aggressive primary brain cancer that currently has minimally effective treatments. Like other cancers, immunosuppression by the PD-L1-PD-1 immune checkpoint complex is a prominent axis by which glioma cells evade the immune system. Myeloid-derived suppressor cells (MDSCs), which are recruited to the glioma microenviroment, also contribute to the immunosuppressed GBM microenvironment by suppressing T cell functions. In this paper, we propose a GBM-specific tumor-immune ordinary differential equations model of glioma cells, T cells, and MDSCs to provide theoretical insights into the interactions between these cells...
May 16, 2023: bioRxiv
https://read.qxmd.com/read/37280525/comprehensive-analyses-of-a-cd8-t-cell-infiltration-related-gene-signature-with-regard-to-the-prediction-of-prognosis-and-immunotherapy-response-in-lung-squamous-cell-carcinoma
#15
JOURNAL ARTICLE
Liang Chen, Yiming Weng, Xue Cui, Qian Li, Min Peng, Qibin Song
Lung squamous cell carcinoma (LUSC) is associated with a worse prognosis than other histological subtypes of non-small cell lung cancer. Due to the vital role of CD8+ T cells in anti-tumor immunity, the characterization of CD8+ T cell infiltration-related (CTLIR) gene signature in LUSC is worthy of in-depth exploration. In our study, tumor tissues of LUSC patients from Renmin Hospital of Wuhan University were stained by multiplex immunohistochemistry to evaluate the density of infiltrated CD8+ T cells and explore the correlation with immunotherapy response...
June 6, 2023: BMC Bioinformatics
https://read.qxmd.com/read/37152280/role-of-the-tumor-microenvironment-in-malignant-melanoma-organoids-during-the-development-and-metastasis-of-tumors
#16
REVIEW
Siyu Zhou, Jinghan Lu, Shiyang Liu, Jiaqi Shao, Zhanwei Liu, Jianjun Li, Wan'an Xiao
Malignant melanoma (MM) is the most metastatic and aggressive form of skin cancer, and carries a high risk of death. Immune-checkpoint inhibitor therapy and molecular-targeted therapy can prolong the survival of patients with advanced MM significantly. However, the low response rate and inevitable drug resistance prevent further improvements in efficacy, which is closely related to the tumor microenvironment (TME). The TME refers to the tumor stroma, including fibroblasts, keratinocytes, immune cells, soluble molecules, and extracellular matrix (ECM)...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/37069585/syndecan-1-as-an-immunogene-in-triple-negative-breast-cancer-regulation-tumor-infiltrating-lymphocyte-in-the-tumor-microenviroment-and-emt-by-tgfb1-smad-pathway
#17
JOURNAL ARTICLE
Ying Zhong, Fangyuan Li, Sumei Zhang, Zhenli Yang, Xinyu Ren, Xi Cao, Yali Xu, Dan Guo, Yidong Zhou, Feng Mao, Songjie Shen, Qiang Sun
BACKGROUND: Immune checkpoint inhibitors are the most studied forms of immunotherapy for triple-negative breast cancer (TNBC). The Cancer Genome Map (TCGA) and METABRIC project provide large-scale cancer samples that can be used for comprehensive and reliable immunity-related gene research. METHODS: We analyzed data from TCGA and METABRIC and established an immunity-related gene prognosis model for breast cancer. The SDC1 expression in tumor and cancer associated fibroblasts (CAFs) was then observed in 282 TNBC patients by immunohistochemistry...
April 17, 2023: Cancer Cell International
https://read.qxmd.com/read/36989719/metabolic-codependencies-in-the-tumor-microenvironment-and-gastric-cancer-difficulties-and-opportunities
#18
REVIEW
Xihe Zhao, Kai Li, Mengyu Chen, Lei Liu
Oncogenesis and the development of tumors affect metabolism throughout the body. Metabolic reprogramming (also known as metabolic remodeling) is a feature of malignant tumors that is driven by oncogenic changes in the cancer cells themselves as well as by cytokines in the tumor microenvironment. These include endothelial cells, matrix fibroblasts, immune cells, and malignant tumor cells. The heterogeneity of mutant clones is affected by the actions of other cells in the tumor and by metabolites and cytokines in the microenvironment...
March 27, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/36874131/tigit-signaling-and-its-influence-on-t-cell-metabolism-and-immune-cell-function-in-the-tumor-microenvironment
#19
REVIEW
Nouria Jantz-Naeem, Romy Böttcher-Loschinski, Katrin Borucki, Marisa Mitchell-Flack, Martin Böttcher, Burkhart Schraven, Dimitrios Mougiakakos, Sascha Kahlfuss
One of the key challenges for successful cancer therapy is the capacity of tumors to evade immune surveillance. Tumor immune evasion can be accomplished through the induction of T cell exhaustion via the activation of various immune checkpoint molecules. The most prominent examples of immune checkpoints are PD-1 and CTLA-4. Meanwhile, several other immune checkpoint molecules have since been identified. One of these is the T cell immunoglobulin and ITIM domain (TIGIT), which was first described in 2009. Interestingly, many studies have established a synergistic reciprocity between TIGIT and PD-1...
2023: Frontiers in Oncology
https://read.qxmd.com/read/36705298/extracellular-vesicles-secreted-by-triple-negative-breast-cancer-stem-cells-trigger-pre-metastatic-niche-remodeling-and-metastatic-growth-in-the-lungs
#20
JOURNAL ARTICLE
Patricia González-Callejo, Petra Gener, Zamira V Díaz-Riascos, Sefora Conti, Patricia Cámara-Sánchez, Roger Riera, Sandra Mancilla, Miguel García-Gabilondo, Vicente Peg, Diego Arango, Anna Rosell, Anna Labernadie, Xavier Trepat, Lorenzo Albertazzi, Simó Schwartz, Joaquin Seras-Franzoso, Ibane Abasolo
Tumor secreted extracellular vesicles (EVs) are potent intercellular signaling platforms. They are responsible for the accommodation of the pre-metastatic niche (PMN) to support cancer cell engraftment and metastatic growth. However, complex cancer cell composition within the tumor increases also the heterogeneity among cancer secreted EVs subsets, a functional diversity that has been poorly explored. This phenomenon is particularly relevant in highly plastic and heterogenous Triple Negative Breast Cancer (TNBC), in which a significant representation of malignant cancer stem cells (CSCs) is displayed...
January 27, 2023: International Journal of Cancer. Journal International du Cancer
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