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https://www.readbyqxmd.com/read/28645254/comparing-self-and-provider-collected-swabbing-for-hpv-dna-testing-in-female-to-male-transgender-adult-patients-a-mixed-methods-biobehavioral-study-protocol
#1
Sari L Reisner, Madeline B Deutsch, Sarah M Peitzmeier, Jaclyn M White Hughto, Timothy Cavanaugh, Dana J Pardee, Sarah McLean, Elliot J Marrow, Matthew J Mimiaga, Lori Panther, Marcy Gelman, Jamison Green, Jennifer Potter
BACKGROUND: Cervical cancer, nearly all cases of which are caused by one of several high-risk strains of the human papillomavirus (hr-HPV), leads to significant morbidity and mortality in individuals with a cervix. Trans masculine (TM) individuals were born with female reproductive organs and identify as male, man, transgender man, or another diverse gender identity different from their female assigned sex at birth. Routine preventive sexual health screening of TM patients is recommended, including screening for cervical cancer and other sexually transmitted infections (STIs); however, as many as one in three TM patients are not up-to-date per recommended U...
June 23, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28640075/maximum-voltage-gradient-technique-for-optimization-of-ablation-for-typical-atrial-flutter-with-zero-fluoroscopy-approach
#2
Karol Deutsch, Janusz Śledź, Mariusz Mazij, Bartosz Ludwik, Michał Labus, Dariusz Karbarz, Bernadetta Pasicka, Michał Chrabąszcz, Arkadiusz Śledź, Monika Klank-Szafran, Laura Vitali-Sendoz, Tomasz Kameczura, Jerzy Śpikowski, Piotr Stec, Marek Ujda, Sebastian Stec
Radiofrequency catheter ablation (RFCA) is an established effective method for the treatment of typical cavo-tricuspid isthmus (CTI)-dependent atrial flutter (AFL). The introduction of 3-dimensional electro-anatomic systems enables RFCA without fluoroscopy (No-X-Ray [NXR]). The aim of this study was to evaluate the feasibility and effectiveness of CTI RFCA during implementation of the NXR approach and the maximum voltage-guided (MVG) technique for ablation of AFL.Data were obtained from prospective standardized multicenter ablation registry...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28638313/real-life-pharmaceutical-treatment-patterns-for-adult-patients-with-focal-epilepsy-in-germany-a-longitudinal-and-cross-sectional-analysis-of-recently-approved-anti-epileptic-drugs
#3
Antje Groth, Thomas Wilke, Simon Borghs, Patrick Gille, Lars Joeres
Objectives: The aim of this study was to investigate the antiepileptic drug (AED) treatment of adults suffering from focal epilepsies (FE) in Germany. Of special interest was the number and percentage of the patients 16 years and older receiving no treatment with an AED, treatment with one AED (monotherapy), treatment with more than one AED, and treatment with a novel AED. The definition for "novel" was newly approved at the time of market entry since 2006 (last 10 years): eslicarbazepine (ESL), lacosamide (LCM), perampanel (PER), and retigabine (RTG)...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/28637077/-tracheostomy-home-care-of-patients-after-long-term-ventilation-on-the-icu-a-position-paper
#4
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28635121/exposure-to-sodium-valproate-during-pregnancy-facial-features-and-signs-of-autism
#5
Rachel Stadelmaier, Hanah Nasri, Curtis K Deutsch, Margaret Bauman, Anne Hunt, Christopher J Stodgell, Jane Adams, Lewis B Holmes
BACKGROUND: Valproic acid (VPA) is the most teratogenic anticonvulsant drug in clinical use today. Children exposed prenatally to VPA have previously been shown to have dysmorphic craniofacial features, identified subjectively but not by anthropometric methods. Exposure to VPA has also been associated with an increased frequency of autism spectrum disorder (ASD). An increased cephalic index (the ratio of the cranial lateral width to the cranial anterior-posterior length) has been observed in children with ASD...
June 21, 2017: Birth defects research
https://www.readbyqxmd.com/read/28632393/the-antinociceptive-agent-sbfi-26-binds-to-anandamide-transporters-fabp5-and-fabp7-at-two-different-sites
#6
Hao-Chi Hsu, Simon Tong, Yuchen Zhou, Matthew W Elmes, Su Yan, Martin Kaczocha, Dale G Deutsch, Robert C Rizzo, Iwao Ojima, Huilin Li
Human FABP5 and FABP7 are intracellular endocannabinoid transporters. SBFI-26 is an -truxillic acid 1-naphthyl monoester that competitively inhibits the activities of FABP5 and FABP7 and produces antinociceptive and anti-inflammatory effects in mice. The synthesis of SBFI-26 yields several stereoisomers, and it is not known how the inhibitor binds the transporters. Here we report co-crystal structures of SBFI-26 in complex with human FABP5 and FABP7 at a resolution of 2.2 Å and 1.9 Å, respectively. We found that only (S)-SBFI-26 was present in the crystal structures...
June 20, 2017: Biochemistry
https://www.readbyqxmd.com/read/28631986/accuracy-statistics-in-predicting-independent-activities-of-daily-living-iadl-capacity-with-comprehensive-and-brief-neuropsychological-test-batteries
#7
Peter Karzmark, Gayle K Deutsch
This investigation was designed to determine the predictive accuracy of a comprehensive neuropsychological and brief neuropsychological test battery with regard to the capacity to perform instrumental activities of daily living (IADLs). Accuracy statistics that included measures of sensitivity, specificity, positive and negative predicted power and positive likelihood ratio were calculated for both types of batteries. The sample was drawn from a general neurological group of adults (n = 117) that included a number of older participants (age >55; n = 38)...
February 22, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28620996/feasibility-of-collecting-patient-reported-outcomes-for-inpatient-rehabilitation-quality-reporting
#8
Allen Walter Heinemann, Anne Deutsch, David Cella, Karon Frances Cook, Linda Foster, Ana Miskovic, Katharine Davis, Arielle Goldsmith
OBJECTIVE: To evaluate rehabilitation inpatients' willingness and ability to complete patient-reported outcomes (PROs) and the burden of completion on patients and staff. DATA SOURCES/STUDY SETTING: Two inpatient rehabilitation facilities. STUDY DESIGN: Patients with neurological disorders were assigned randomly to receive a nominal monetary incentive during or 1 month after the stay. DATA COLLECTION: Patients responded using a tablet computer or paper...
June 15, 2017: Health Services Research
https://www.readbyqxmd.com/read/28619752/the-met-axl-fgfr-inhibitor-s49076-impairs-aurora-b-activity-and-improves-the-antitumor-efficacy-of-radiotherapy
#9
Céline Clémenson, Cyrus Chargari, Winchygn Liu, Michele Mondini, Charles Ferté, Mike F Burbridge, Valérie Cattan, Anne Jacquet-Bescond, Eric Deutsch
Several therapeutic agents targeting HGF/MET signaling are under clinical development as single agents or in combination, notably with anti-EGFR therapies in non-small cell lung cancer (NSCLC). However, despite increasing data supporting a link between MET, irradiation and cancer progression, no data regarding the combination of MET-targeting agents and radiotherapy are available from the clinic. S49076 is an oral ATP-competitive inhibitor of MET, AXL and FGFR1-3 receptors that is currently in phase I/II clinical trials in combination with gefinitib in NSCLC patients whose tumors show resistance to EGFR inhibitors...
June 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28617009/-the-feasibility-of-implementing-cognitive-remediation-for-work-in-community-based-psychiatric-rehabilitation-programs-correction-to-mcgurk-et-al-2017
#10
(no author information available yet)
Reports an error in "The feasibility of implementing cognitive remediation for work in community based psychiatric rehabilitation programs" by Susan R. McGurk, Kim T. Mueser, Melanie A. Watkins, Carline M. Dalton and Heather Deutsch (Psychiatric Rehabilitation Journal, 2017[Mar], Vol 40[1], 79-86). In the article, the author order was incorrect due to a printer error. The online version of this article has been corrected. (The following abstract of the original article appeared in record 2017-13255-004.) Objective: Adding cognitive remediation to vocational rehabilitation services improves cognitive and work functioning in people with serious mental illness, but despite interest, the uptake of cognitive programs into community services has been slow...
June 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28611855/variables-to-predict-nephrological-disease-in-general-and-glomerulonephritis-in-particular-in-patients-with-microhematuria
#11
Carsten Paul Bramlage, Manuel Wallbach, David Ellenberger, Cornelia Deutsch, Joan Minguet, Katherine Helen Smith, Johanna Stock, Alina Goninski, Peter Bramlage, Michael Koziolek, Gerhard Anton Mueller
BACKGROUND: Microhematuria (MH) is a symptom frequently leading to uncertainty as to when a nephrology referral is appropriate. Because MH may be indicative of severe kidney disorders, prompt diagnosis and potential treatment initiation can be important. We aimed to identify further variables that point at a nephrological cause, in particular of glomerulonephritis (GN), when MH is diagnosed. METHODS: A retrospective analysis of data acquired from patients attending a nephrology office due to MH was performed...
July 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28604297/hans-joachim-freisleben%C3%A2-and-helga-petersen%C3%A2-eds-sie-kamen-als-forscher-und-%C3%A3-rzte%C3%A2-%C3%A2-500-jahre-deutsch-indonesische-medizingeschichte-cologne-koeppe-2016-pp-%C3%A2-xii%C3%A2-%C3%A2-592-%C3%A2-98-00-hardback-isbn-%C3%A2-978-3-89645-225-2
#12
https://www.readbyqxmd.com/read/28603525/modulating-both-tumor-cell-death-and-innate-immunity-is-essential-for-improving-radiation-therapy-effectiveness
#13
REVIEW
Qiuji Wu, Awatef Allouch, Isabelle Martins, Catherine Brenner, Nazanine Modjtahedi, Eric Deutsch, Jean-Luc Perfettini
Radiation therapy is one of the cornerstones of cancer treatment. In tumor cells, exposure to ionizing radiation (IR) provokes DNA damages that trigger various forms of cell death such as apoptosis, necrosis, autophagic cell death, and mitotic catastrophe. IR can also induce cellular senescence that could serve as an additional antitumor barrier in a context-dependent manner. Moreover, accumulating evidence has demonstrated that IR interacts profoundly with tumor-infiltrating immune cells, which cooperatively drive treatment outcomes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28596060/-medical-prevention-and-treatment-of-radiation-induced-pulmonary-complications
#14
A Vallard, C Rancoule, H Le Floch, J-B Guy, S Espenel, C Le Péchoux, É Deutsch, N Magné, C Chargari
Radiation-induced lung injuries mainly include the (acute or sub-acute) radiation pneumonitis, the lung fibrosis and the bronchiolitis obliterans organizing pneumonia (BOOP). The present review aims at describing the diagnostic process, the current physiopathological knowledge, and the available (non dosimetric) preventive and curative treatments. Radiation-induced lung injury is a diagnosis of exclusion, since clinical, radiological, or biological pathognomonic evidences do not exist. Investigations should necessarily include a thoracic high resolution CT-scan and lung function tests with a diffusing capacity of the lung for carbon monoxide...
June 5, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28595250/prospective-split-face-randomized-long-term-blinded-objective-comparison-of-the-performance-and-tolerability-of-two-new-hyaluronic-acid-fillers
#15
Patrick Trevidic, Pierre Andre, Laurent Benadiba, Jean-Jacques Deutsch, Olivier Galatoire, Philippe Garcia, Anne Grand-Vincent, Sylvie Boisnic, Jean-Charles Kerihuel, Catherine Salomon
BACKGROUND: There are requirements for long-term, objective comparisons of hyaluronic acid (HA) dermal fillers. OBJECTIVE: To compare efficacy and tolerability of ART FILLER Universal (AFU) and ART FILLER Fine lines (AFFL) with the existing HA fillers for the treatment of nasolabial folds and crow's feet. MATERIALS AND METHODS: Prospective, randomized, rater- and patient-blind, split-face comparison of AFU with JUVEDERM Ultra 3 (JUV) and AFFL with FIRST LINES PureSense (FLPS)...
June 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28589903/tumor-biomarker-conversion-between-primary-and-metastatic-breast-cancer-mrna-assessment-and-its-concordance-with-immunohistochemistry
#16
Stefan Stefanovic, Ralph Wirtz, Thomas M Deutsch, Andreas Hartkopf, Peter Sinn, Zsuzsanna Varga, Bettina Sobottka, Lakis Sotiris, Florin-Andrei Taran, Christoph Domschke, Andre Hennigs, Sara Y Brucker, Christof Sohn, Florian Schuetz, Andreas Schneeweiss, Markus Wallwiener
Biomarker changes between primary (PT) and metastatic tumor (MT) site may be significant in individualizing treatment strategies and can result from actual clonal evolution, biomarker conversion, or technical limitations of diagnostic tests.This study explored biomarker conversion during breast cancer (BC) progression in 67 patients with different tumor subtypes and metastatic sites via mRNA quantification and subsequently analyzed the concordance between real-time qPCR and immunohistochemistry (IHC). Immunostaining for estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki-67 was performed on formalin-fixed, paraffin-embedded PT and MT tissue sections...
May 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28589544/accuracy-of-predictive-ability-measures-for-survival-models
#17
Philippe Flandre, Reena Deutsch, John O'Quigley
One aspect of an analysis of survival data based on the proportional hazards model that has been receiving increasing attention is that of the predictive ability or explained variation of the model. A number of contending measures have been suggested, including one measure, R(2) (β), which has been proposed given its several desirable properties, including its capacity to accommodate time-dependent covariates, a major feature of the model and one that gives rise to great generality. A thorough study of the properties of available measures, including the aforementioned measure, has been carried out recently...
June 7, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28586932/stellungnahme-des-berufsverbandes-der-augen%C3%A3-rzte-deutschlands-der-deutschen-ophthalmologischen-gesellschaft-und-der-retinologischen-gesellschaft-oct-angiografie-in-deutschland-pr%C3%A3-sentation-nomenklatur-und-zukunftsw%C3%A3-nsche-stand-januar-2017
#18
https://www.readbyqxmd.com/read/28582742/bioaccessibility-of-pahs-in-contaminated-soils-comparison-of-five-in-vitro-methods-with-tenax-as-a-sorption-sink
#19
Shujun Zhang, Chao Li, Yunzi Li, Ruirui Zhang, Peng Gao, Xinyi Cui, Lena Q Ma
For hydrophobic organic contaminants, physiologically based in vitro methods may need to include a sorption sink to simulate in vivo intestinal uptake. We compared PAH bioaccessibility in contaminated soils using five in vitro methods including physiologically based extraction test (PBET), in vitro digestion assay (IVD), method from Deutsches Institut für Normung (DIN), unified bioaccessibility method (UBM), and fed organic estimation human simulation test (FOREhST) in the absence and presence of Tenax as a sorption sink...
June 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28582580/transaortic-transcatheter-aortic-valve-implantation-using-sapien-xt-or-sapien-3-valves-in-the-route-registry%C3%A2
#20
Mauro Romano, Derk Frank, Riccardo Cocchieri, Dariusz Jagielak, Nikolaos Bonaros, Marco Aiello, Joel Lapeze, Mika Laine, Sidney Chocron, Douglas Muir, Walter Eichinger, Matthias Thielmann, Louis Labrousse, Kjell Arne Rein, Jean-Philippe Verhoye, Gino Gerosa, Hardy Baumbach, Cornelia Deutsch, Peter Bramlage, Martin Thoenes, Vinayak Bapat
OBJECTIVES: Transaortic (TAo) access for transcatheter aortic valve implantation (TAVI) is an alternative to the conventional transfemoral or transapical routes. Data comparing the characteristics and outcomes of TAo-TAVI using the SAPIEN XT and SAPIEN 3 heart valves are scarce. The objective of the current analysis was to provide such information. METHODS: ROUTE is an international, prospective, observational registry. Patients with severe calcific aortic stenosis scheduled for TAo-TAVI with an Edwards SAPIEN XT or a SAPIEN 3 heart valve were consecutively enrolled at 22 centres across Europe between February 2013 and February 2015...
June 5, 2017: Interactive Cardiovascular and Thoracic Surgery
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