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https://www.readbyqxmd.com/read/27931189/adaptation-of-propionibacterium-freudenreichii-to-long-term-survival-under-gradual-nutritional-shortage
#1
Flavia Figueira Aburjaile, Marine Rohmer, Hugues Parrinello, Marie-Bernadette Maillard, Eric Beaucher, Gwénaële Henry, Aurélie Nicolas, Marie-Noëlle Madec, Anne Thierry, Sandrine Parayre, Stéphanie-Marie Deutsch, Muriel Cocaign-Bousquet, Anderson Miyoshi, Vasco Azevedo, Yves Le Loir, Hélène Falentin
BACKGROUND: Propionibacterium freudenreichii is an Actinobacterium widely used in the dairy industry as a ripening culture for Swiss-type cheeses, for vitamin B12 production and some strains display probiotic properties. It is reportedly a hardy bacterium, able to survive the cheese-making process and digestive stresses. RESULTS: During this study, P. freudenreichii CIRM-BIA 138 (alias ITG P9), which has a generation time of five hours in Yeast Extract Lactate medium at 30 °C under microaerophilic conditions, was incubated for 11 days (9 days after entry into stationary phase) in a culture medium, without any adjunct during the incubation...
December 8, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27931056/-guideline-s2k-awmf-of-the-deutsche-gesellschaft-f%C3%A3-r-pneumologie-und-beatmungsmedizin-and-the-deutsche-gesellschaft-f%C3%A3-r-arbeitsmedizin-und-umweltmedizin-diagnostics-and-expert-opinion-in-the-occupational-disease-no-4101-silicosis-including-coal-worker-s-pneumoconiosis
#2
X Baur, M Heger, R M Bohle, K G Hering, K Hofmann-Preiß, D Nowak, A Tannapfel, H Teschler, T Voshaar, T Kraus
During the last 1.5 years an update of the guideline on silicosis was made by an interdisciplinary working group. New medical and scientific knowledge and the experience in expert opinion practice were taken into account.By preparing the initial guideline in 2010 standardization of diagnostics and adaption of the "Moers convention" which was not based on medical knowledge was in the focus, whereas the current update deals with fine emendation and extension, especially of the compensation rate (adaption with the Reichenhall recommendation)...
December 2016: Pneumologie
https://www.readbyqxmd.com/read/27931054/-tb-screening-of-pregnant-women-in-accordance-with-the-german-protection-against-infection-act
#3
(no author information available yet)
Pregnant women should be tested with immune tests for tuberculosis when they undergo TB screening according to the German Infectious Diseases Protection Act. Interferon Gamma Release Assays (IGRAs) should be the priority tests used for pregnant refugees and asylum seekers, especially when migrating from high incidence countries (> 20 cases/100.000 population according to the ECDC) or when they fled from crisis regions; positive tuberculin skin tests should be veryfied with IGRA. Once immunological tests are suggesting a latent tuberculosis infection it should be considered that pregnant women have an increased risk of developing active tuberculosis with potential health threats for the unborn child...
December 2016: Pneumologie
https://www.readbyqxmd.com/read/27924013/the-proteomexchange-consortium-in-2017-supporting-the-cultural-change-in-proteomics-public-data-deposition
#4
Eric W Deutsch, Attila Csordas, Zhi Sun, Andrew Jarnuczak, Yasset Perez-Riverol, Tobias Ternent, David S Campbell, Manuel Bernal-Llinares, Shujiro Okuda, Shin Kawano, Robert L Moritz, Jeremy J Carver, Mingxun Wang, Yasushi Ishihama, Nuno Bandeira, Henning Hermjakob, Juan Antonio Vizcaíno
The ProteomeXchange (PX) Consortium of proteomics resources (http://www.proteomexchange.org) was formally started in 2011 to standardize data submission and dissemination of mass spectrometry proteomics data worldwide. We give an overview of the current consortium activities and describe the advances of the past few years. Augmenting the PX founding members (PRIDE and PeptideAtlas, including the PASSEL resource), two new members have joined the consortium: MassIVE and jPOST. ProteomeCentral remains as the common data access portal, providing the ability to search for data sets in all participating PX resources, now with enhanced data visualization components...
October 18, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27922153/-radioiodine-therapy-for-benign-thyroid-diseases-version-5-german-guideline
#5
Markus Dietlein, Frank Grünwald, Matthias Schmidt, Peter Schneider, Frederik A Verburg, Markus Luster
The version 5 of the guideline for radioiodine therapy of benign thyroid disorders is an update of the version 4, which was published by the German Society of Nuclear Medicine (Deutsche Gesellschaft für Nuklearmedizin, DGN) in co-ordination with the German Society of Endocrinology (Deutsche Gesellschaft für Endokrinologie, DGE, Sektion Schilddrüse) and the German Society of General- and Visceral-Surgery (Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie, DGAV) in 2007. This guideline was harmonized with the recommendations of the European Association of Nuclear Medicine (EANM)...
December 6, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27917713/antiplatelets-and-antithrombotics-in-patients-with-liver-insufficiency-from-pathophysiology-to-clinical-practice
#6
Melanie Deutsch, John Koskinas
The liver represents the site of synthesis of most procoagulant and anticoagulant factors, fibrinolytic proteins and thrombopoetin while being also involved in the clearance of hemostatic and fibrinolyic proteins. Therefore in patients with liver insufficiency a great variety of disturbances can be documented resulting however in a new "rebalanced" hemostatic system with a labile equilibrium between thromboses or bleeding. Interestingly patients with liver insufficiency may present with arterial or venous thrombotic episodes requiring antiplatelet and/or antithrombotic therapy despite low platelet count or prolonged INR...
December 5, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27911553/arbitrary-dicke-state-control-of-symmetric-rydberg-ensembles
#7
Tyler Keating, Charles H Baldwin, Yuan-Yu Jau, Jongmin Lee, Grant W Biedermann, Ivan H Deutsch
We study the production of arbitrary superpositions of Dicke states via optimal control. We show that N atomic hyperfine qubits, interacting symmetrically via the Rydberg blockade, are well described by the Jaynes-Cummings Hamiltonian and fully controllable by phase-modulated microwaves driving Rydberg-dressed states. With currently feasible parameters, it is possible to generate states of ∼ten hyperfine qubits in ∼1  μs, assuming a fast microwave phase switching time. The same control can be achieved with a "dressed-ground control" scheme, which reduces the demands for fast phase switching at the expense of increased total control time...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27902668/pneumatosis-intestinalis-due-to-child-abuse
#8
Stephanie Anne Deutsch, Cindy W Christian
Pneumatosis intestinalis (PI) and the presence of portal venous gas (PVG) are commonly considered pathognomonic for necrotizing enterocolitis in the neonatal period; however, these 2 radiographic findings have been documented in all age groups in a variety of clinical settings and medical conditions including respiratory, cardiac, rheumatologic, gastrointestinal disorders, and traumatic injury. In children, intramural dissection of intestinal gas in the absence of clinical symptoms suggestive of necrotizing enterocolitis should raise concern for a traumatic etiology, including injuries sustained from child physical abuse...
November 29, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27885987/accelerated-cell-divisions-drive-the-outgrowth-of-the-regenerating-spinal-cord-in-axolotls
#9
Fabian Rost, Aida Rodrigo Albors, Vladimir Mazurov, Lutz Brusch, Andreas Deutsch, Elly M Tanaka, Osvaldo Chara
Axolotls are unique in their ability to regenerate the spinal cord. However, the mechanisms that underlie this phenomenon remain poorly understood. Previously, we showed that regenerating stem cells in the axolotl spinal cord revert to a molecular state resembling embryonic neuroepithelial cells and functionally acquire rapid proliferative divisions (Rodrigo Albors et al., 2015). Here, we refine the analysis of cell proliferation in space and time and identify a high-proliferation zone in the regenerating spinal cord that shifts posteriorly over time...
November 25, 2016: ELife
https://www.readbyqxmd.com/read/27883301/what-s-in-a-guideline-developing-collaborative-and-sound-research-designs-that-substantiate-best-practice-recommendations-for-transgender-health-care
#10
Madeline B Deutsch, Asa Radix, Sari Reisner
Transgender medicine presents a particular challenge for the development of evidence-based guidelines, due to limitations in the available body of evidence as well as the exclusion of gender identity data from most public health surveillance activities. The guidelines that have been published are often based on expert opinion, small studies, and data gathered outside the US. The existence of guidelines, however, helps legitimate the need for gender-affirming medical and surgical interventions. Research conducted on transgender populations should be grounded in gender-affirming methodologies and focus on key areas such as health outcomes after gender-affirming interventions...
November 1, 2016: AMA Journal of Ethics
https://www.readbyqxmd.com/read/27879066/xxix-%C3%A2-symposium-augustanum-jahrestagung-der-deutsch-italienischen-gesellschaft-f%C3%A3-r-dermatologie-e-%C3%A2-v-in-genua-am-27-%C3%A2-mai%C3%A2-2016
#11
Claudio Feliciani, Michael Hertl, Bernd-Rüdiger Balda
No abstract text is available yet for this article.
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27876890/why-one-size-fits-all-vaso-modulatory-interventions-fail-to-control-glioma-invasion-in-silico-insights
#12
J C L Alfonso, A Köhn-Luque, T Stylianopoulos, F Feuerhake, A Deutsch, H Hatzikirou
Gliomas are highly invasive brain tumours characterised by poor prognosis and limited response to therapy. There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies involve tumour blood vessel deterioration and normalisation. The former aims at tumour infarction and nutrient deprivation induced by blood vessel occlusion/collapse. In contrast, the therapeutic intention of normalising the abnormal tumour vasculature is to improve the efficacy of conventional treatment modalities...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27871334/exploiting-members-of-the-bahd-acyltransferase-family-to-synthesize-multiple-hydroxycinnamate-and-benzoate-conjugates-in-yeast
#13
Aymerick Eudes, Maxence Mouille, David S Robinson, Veronica T Benites, George Wang, Lucien Roux, Yi-Lin Tsai, Edward E K Baidoo, Tsan-Yu Chiu, Joshua L Heazlewood, Henrik V Scheller, Aindrila Mukhopadhyay, Jay D Keasling, Samuel Deutsch, Dominique Loqué
BACKGROUND: BAHD acyltransferases, named after the first four biochemically characterized enzymes of the group, are plant-specific enzymes that catalyze the transfer of coenzyme A-activated donors onto various acceptor molecules. They are responsible for the synthesis in plants of a myriad of secondary metabolites, some of which are beneficial for humans either as therapeutics or as specialty chemicals such as flavors and fragrances. The production of pharmaceutical, nutraceutical and commodity chemicals using engineered microbes is an alternative, green route to energy-intensive chemical syntheses that consume petroleum-based precursors...
November 21, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27869531/associations-between-lifestyle-characteristics-and-the-presence-of-nonalcoholic-fatty-liver-disease-a-case-control-study
#14
Christina N Katsagoni, Michael Georgoulis, George V Papatheodoridis, Elisabeth Fragopoulou, Panagiota Ioannidou, Mariviki Papageorgiou, Alexandra Alexopoulou, Nikolaos Papadopoulos, Melanie Deutsch, Meropi D Kontogianni
BACKGROUND: Dietary and physical activity (PA) habits have been suggested as important factors for nonalcoholic fatty liver disease (NAFLD). Published data are mainly focused on the effect of either diet or exercise, whereas data on other aspects like sleep remain sparse. The aim of this study was to explore potential associations between dietary intake, PA, and sleeping habits, and the presence of NAFLD. METHODS: One hundred patients with ultrasound-proven NAFLD and 55 healthy controls matched for age, sex, and body mass index were included...
November 21, 2016: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/27865364/induction-chemotherapy-with-docetaxel-cisplatin-and-fluorouracil-followed-by-concurrent-chemoradiotherapy-or-chemoradiotherapy-alone-in-locally-advanced-non-endemic-nasopharyngeal-carcinoma
#15
Dan Ou, Pierre Blanchard, Clément El Khoury, Francesca De Felice, Caroline Even, Antonin Levy, France Nguyen, François Janot, Philippe Gorphe, Eric Deutsch, Stephane Temam, Yungan Tao
OBJECTIVES: To evaluate the efficacy of induction chemotherapy with docetaxel, cisplatin and fluorouracil (TPF) followed by concurrent chemoradiotherapy (IC+CCRT) or CCRT alone in non-endemic locally advanced nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS: Data of 106 patients with NPC treated from January 1999 to June 2012 with IC+CCRT (n=58) or CCRT alone (n=48) were retrospectively reviewed. RESULTS: Median follow-up was 6...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27862987/einsatz-und-wirksamkeit-von-systemtherapien-bei-erwachsenen-mit-schwerer-neurodermitis-erste-ergebnisse-des-deutschen-neurodermitis-registers-treatgermany
#16
Jochen Schmitt, Susanne Abraham, Freya Trautmann, Victoria Stephan, Regina Fölster-Holst, Bernhard Homey, Thomas Bieber, Natalija Novak, Michael Sticherling, Matthias Augustin, Andreas Kleinheinz, Peter Elsner, Stephan Weidinger, Thomas Werfel
HINTERGRUND: Versorgungsregister dienen der Erfassung des Einsatzes und der Wirksamkeit von Therapien unter realen Versorgungsbedingungen und sind als Basis einer evidenzbasierten Gesundheitsversorgung unverzichtbar. METHODIK: Das deutsche Neurodermitis-Register TREATgermany wurde als weltweit erstes Register für Patienten mit schwerer Neurodermitis 2011 initiiert. Erwachsene mit schwerer Neurodermitis (aktuelle/frühere antientzündliche Systemtherapie und/oder objektiver SCORAD ≥ 40) werden über einen Zeitraum von 24 Monaten prospektiv beobachtet...
November 10, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27855988/development-of-a-platelet-adhesion-transport-equation-for-a-computational-thrombosis-model
#17
Joshua O Taylor, Ling Yang, Steven Deutsch, Keefe B Manning
Thrombosis is a significant issue for cardiovascular device development and use. While thrombosis models are available, very few are device-related and none have been thoroughly validated experimentally. Here, we introduce a surface adherent platelet transport equation into a continuum model to account for the biomaterial interface/blood interaction. Using a rotating disc system and polyurethane-urea material, we characterize steady and pulsatile flow fields using laser Doppler velocimetry. In vitro measurements of platelet adhesion are used in combination with the LDV data to provide further experimental validation...
November 10, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27850768/1131-biometric-stress-tracking-and-analysis-during-acute-icu-care-using-a-novel-biosensing-garment
#18
Nicholas Slamon, Scott Penfil, Ellen Deutsch, Vinay Nadkarni
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849993/353-knowledge-of-european-high-school-students-on-resuscitation-and-first-aid-measures
#19
Attila Pandur, Balint Banfai, Henrietta Csonka, Emese Pek, Krisztine Deutsch, Jozsef Betlehem
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27834580/nkg2d-ligand-expression-in-pediatric-brain-tumors
#20
Kristen Haberthur, Kathryn Brennan, Virginia Hoglund, Stephanie Balcaitis, Harrison Chinn, Amira Davis, Shannon Kreuser, Conrad Winter, Sarah E S Leary, Gail H Deutsch, Richard G Ellenbogen, Courtney A Crane
Adult brain tumors establish an immunosuppressive tumor microenvironment as a modality of immune escape, with several immunotherapies designed to overcome this barrier. However, the relationship between tumor cells and immune cells in pediatric brain tumor patients is not as well-defined. In this study, we sought to determine whether the model of immune escape observed in adult brain tumors is reflected in patients with pediatric brain tumors by evaluating NKG2D ligand expression on tissue microarrays created from patients with a variety of childhood brain tumor diagnoses, and infiltration of Natural Killer and myeloid cells...
November 11, 2016: Cancer Biology & Therapy
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