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https://www.readbyqxmd.com/read/28930063/who-s-got-the-booze-the-role-of-access-to-alcohol-in-the-relations-between-social-status-and-individual-use
#1
Arielle R Deutsch, Douglas Steinley, Kenneth J Sher, Wendy S Slutske
OBJECTIVE: The findings of previous research that examined relationships between popularity and alcohol use in adolescents have been mixed, and few hypotheses have proposed mechanisms for this relationship. The current study expands on previous literature (a) by examining a possible mechanism that can explain the relation between popularity and alcohol use (home access to alcohol) and (b) by using another sociometric measure ("betweenness"), beyond popularity, that may relate more to home alcohol access...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28919593/electrocardiographic-algorithms-to-guide-a-management-strategy-of-idiopathic-outflow-tract-ventricular-arrhythmias
#2
Bartosz Ludwik, Karol Deutsch, Mariusz Mazij, Janusz Śledź, Aleksandra Morka, Michał Labus, Michał Chrabąszcz, Bartosz Szafran, Jerzy Śpikowski, Lesław Szydłowski, Sebastian M Stec
INTRODUCTION    The current guidelines of the European Society of Cardiology outlined electrocardiographic (ECG) differentiation of site of origin (SOO) in patients with idiopathic ventricular arrhythmias (IVA).  OBJECTIVES    The aim of this study was to compare three ECG algorithms for differentiating SOO and to determine their diagnostic value for the management of outflow tract IVA. PATIENTS AND METHODS    Patients with IVA with inferior axis who underwent successful radiofrequency catheter ablation (RFCA) using the 3D-electroanatomical system were analyzed...
September 6, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28918908/macrophage-biology-plays-a-central-role-during-ionizing-radiation-elicited-tumor-response
#3
REVIEW
Qiuji Wu, Awatef Allouch, Isabelle Martins, Nazanine Modjtahedi, Eric Deutsch, Jean-Luc Perfettini
Radiation therapy is one of the major therapeutic modalities for most solid tumors. The anti-tumor effect of radiation therapy consists of the direct tumor cell killing, as well as the modulation of tumor microenvironment and the activation of immune response against tumors. Radiation therapy has been shown to promote immunogenic cells death, activate dendritic cells and enhance tumor antigen presentation and anti-tumor T cell activation. Radiation therapy also programs innate immune cells such as macrophages that leads to either radiosensitization or radioresistance, according to different tumors and different radiation regimen studied...
August 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28916879/a-score-combining-baseline-neutrophilia-and-primary-tumor-suvpeak-measured-from-fdg-pet-is-associated-with-outcome-in-locally-advanced-cervical-cancer
#4
Antoine Schernberg, Sylvain Reuze, Fanny Orlhac, Irène Buvat, Laurent Dercle, Roger Sun, Elaine Limkin, Alexandre Escande, Christine Haie-Meder, Eric Deutsch, Cyrus Chargari, Charlotte Robert
PURPOSE: We investigated whether a score combining baseline neutrophilia and a PET biomarker could predict outcome in patients with locally advanced cervical cancer (LACC). METHODS: Patients homogeneously treated with definitive chemoradiation plus image-guided adaptive brachytherapy (IGABT) between 2006 and 2013 were analyzed retrospectively. We divided patients into two groups depending on the PET device used: a training set (TS) and a validation set (VS). Primary tumors were semi-automatically delineated on PET images, and 11 radiomics features were calculated (LIFEx software)...
September 15, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28915585/time-dependent-modulation-of-tumor-radiosensitivity-by-a-pan-hdac-inhibitor-abexinostat
#5
Sofia Rivera, Céline Leteur, Frédérique Mégnin, Frédéric Law, Isabelle Martins, Ioana Kloos, Stéphane Depil, Nazanine Modjtahedi, Jean Luc Perfettini, Christophe Hennequin, Eric Deutsch
Despite prominent role of radiotherapy in lung cancer management, there is an urgent need for strategies increasing therapeutic efficacy. Reversible epigenetic changes are promising targets for combination strategies using HDAC inhibitors (HDACi). Here we evaluated on two NSCLC cell lines, the antitumor effect of abexinostat, a novel pan HDACi combined with irradiation in vitro in normoxia and hypoxia, by clonogenic assays, demonstrating that abexinostat enhances radiosensitivity in a time dependent way with mean SER10 between 1...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915584/a-phase-1-dose-escalation-study-of-the-oral-histone-deacetylase-inhibitor-abexinostat-in-combination-with-standard-hypofractionated-radiotherapy-in-advanced-solid-tumors
#6
Eric Deutsch, Elizabeth Cohen-Jonathan Moyal, Vanesa Gregorc, Paolo Andrea Zucali, Jean Menard, Jean-Charles Soria, Ioana Kloos, Jeff Hsu, Ying Luan, Emily Liu, Remus Vezan, Thorsten Graef, Sofia Rivera
Current treatments for advanced solid tumors tend to be only palliative. Although radiotherapy is administered with a curative intent, radioresistance and dose-limiting toxicities pose limitations to treatment. Abexinostat, an oral pan-histone deacetylase inhibitor, demonstrated enhanced sensitivity to radiation in various solid tumor cell lines. We conducted an exploratory, phase 1, dose-escalation study of abexinostat in combination with standard hypofractionated radiotherapy in patients with advanced solid tumors treated in a palliative setting...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28911209/intracellular-activation-of-ovastacin-mediates-pre-fertilization-hardening-of-the-zona-pellucida
#7
Hagen Körschgen, Michael Kuske, Konstantin Karmilin, Irene Yiallouros, Melanie Balbach, Julia Floehr, Dagmar Wachten, Willi Jahnen-Dechent, Walter Stöcker
STUDY QUESTION: How and where is pro-ovastacin activated and how does active ovastacin regulate zona pellucida hardening (ZPH) and successful fertilization? STUDY FINDING: Ovastacin is partially active before exocytosis and pre-hardens the zona pellucida (ZP) before fertilization. WHAT IS KNOWN ALREADY: The metalloproteinase ovastacin is stored in cortical granules, it cleaves zona pellucida protein 2 (ZP2) upon fertilization and thereby destroys the ZP sperm ligand and triggers ZPH...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28898338/-response-to-abvd-chemotherapeutic-protocol-in-patients-with-early-stage-hodgkin%C3%A2-s-lymphoma
#8
Javier Díaz, Katherine Soto, Daniel Ernst
BACKGROUND: Recent trials show that > 90% of patients with early stage Hodgkin`s Lymphoma (ESHL) can be cured, especially when using the ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapeutic (CT) protocol. The use of radiotherapy (RT) is variable and can be selected according to the presence of specific risk factors, including PET-CT, as recently reported. AIM: To report the experience in the treatment of ESHL. MATERIAL AND METHODS: Retrospective and descriptive analysis of patients with ESHL treated at the Red de Salud UC-Christus between 2011-2015...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28895635/stellungnahme-des-berufsverbandes-der-augen%C3%A3-rzte-deutschlands-der-deutschen-ophthalmologischen-gesellschaft-%C3%A2-erarbeitet-von-der-gemeinsamen-kommission-recht-augen%C3%A3-rztliche-beurteilung-im-schwerbehindertenrecht-und-bei-blindheit
#9
https://www.readbyqxmd.com/read/28893525/-doses-to-organs-at-risk-in-conformational-and-stereotactic-body-radiation-therapy-liver
#10
K Debbi, G Janoray, N Scher, É Deutsch, F Mornex
The liver is an essential organ that ensures many vital functions such as metabolism of bilirubin, glucose, lipids, synthesis of coagulation factors, destruction of many toxins, etc. The hepatic parenchyma can be irradiated during the management of digestive tumors, right basithoracic, esophagus, abdomen in toto or TBI. In addition, radiotherapy of the hepatic area, which is mainly stereotactic, now occupies a central place in the management of primary or secondary hepatic tumors. Irradiation of the whole liver, or part of it, may be complicated by radiation-induced hepatitis...
September 8, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28888745/-repair-and-time-dose-factor-the-example-of-spinal-cord-irradiation
#11
C Chargari, P Maroun, G Louvel, M Drouet, D Riccobono, S François, F Dhermain, J-M Cosset, É Deutsch
The question whether a reirradiation is possible, with either curative of palliative intent, is a frequent issue and a true therapeutic challenge, in particular for a critical organ sensitive to cumulative dose, such as the spinal cord. Preclinical experimental data, based on debatable models that are hardly transferable to patients, suggest that there is a possibility of reirradiation, beyond the classical threshold for dose constraints, taking into account the "time-dose factor". Although the underlying biological mechanisms are however uncertain, scarce clinical data seem to confirm that the tolerance of spinal cord to reirradiation does exist, provided that a particular attention to total dose is given...
September 6, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28887440/a-global-staphylococcus-aureus-proteome-resource-applied-to-the-in-vivo-characterization-of-host-pathogen-interactions
#12
Stephan Michalik, Maren Depke, Annette Murr, Manuela Gesell Salazar, Ulrike Kusebauch, Zhi Sun, Tanja C Meyer, Kristin Surmann, Henrike Pförtner, Petra Hildebrandt, Stefan Weiss, Laura Marcela Palma Medina, Melanie Gutjahr, Elke Hammer, Dörte Becher, Thomas Pribyl, Sven Hammerschmidt, Eric W Deutsch, Samuel L Bader, Michael Hecker, Robert L Moritz, Ulrike Mäder, Uwe Völker, Frank Schmidt
Data-independent acquisition mass spectrometry promises higher performance in terms of quantification and reproducibility compared to data-dependent acquisition mass spectrometry methods. To enable high-accuracy quantification of Staphylococcus aureus proteins, we have developed a global ion library for data-independent acquisition approaches employing high-resolution time of flight or Orbitrap instruments for this human pathogen. We applied this ion library resource to investigate the time-resolved adaptation of S...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882707/functional-connectivity-of-large-scale-brain-networks-in-patients-with-anti-nmda-receptor-encephalitis-an-observational-study
#13
Michael Peer, Harald Prüss, Inbal Ben-Dayan, Friedemann Paul, Shahar Arzy, Carsten Finke
BACKGROUND: In anti-NMDA receptor (NMDAR) encephalitis, antibody-mediated dysfunction of NMDARs causes severe neuropsychiatric symptoms, including psychosis, memory deficits, and movement disorders. However, it remains elusive how antibody-mediated NMDAR dysfunction leads to these symptoms, and whether the symptoms arise from impairment in specific brain regions and the interactions between impaired regions. METHODS: In this observational study, we recruited 43 patients with anti-NMDAR encephalitis from a tertiary university hospital and 43 age-matched and sex-matched healthy controls without a history of neurological or psychiatric disorders, who were recruited from the general population of Berlin...
September 4, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28881657/tumor-biomarker-conversion-between-primary-and-metastatic-breast-cancer-mrna-assessment-and-its-concordance-with-immunohistochemistry
#14
Stefan Stefanovic, Ralph Wirtz, Thomas M Deutsch, Andreas Hartkopf, Peter Sinn, Zsuzsanna Varga, Bettina Sobottka, Lakis Sotiris, Florin-Andrei Taran, Christoph Domschke, Andre Hennigs, Sara Y Brucker, Christof Sohn, Florian Schuetz, Andreas Schneeweiss, Markus Wallwiener
Biomarker changes between primary (PT) and metastatic tumor (MT) site may be significant in individualizing treatment strategies and can result from actual clonal evolution, biomarker conversion, or technical limitations of diagnostic tests. This study explored biomarker conversion during breast cancer (BC) progression in 67 patients with different tumor subtypes and metastatic sites via mRNA quantification and subsequently analyzed the concordance between real-time qPCR and immunohistochemistry (IHC). Immunostaining for estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki-67 was performed on formalin-fixed, paraffin-embedded PT and MT tissue sections...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880368/optimization-of-monte-carlo-particle-transport-parameters-and-validation-of-a-novel-high-throughput-experimental-setup-to-measure-the-biological-effects-of-particle-beams
#15
Darshana Patel, Lawrence Bronk, Fada Guan, Christopher R Peeler, Stephan Brons, Ivana Dokic, Amir Abdollahi, Claudia Rittmüller, Oliver Jäkel, David Grosshans, Radhe Mohan, Uwe Titt
PURPOSE: Accurate modeling of the relative biological effectiveness (RBE) of particle beams requires increased systematic in vitro studies with human cell lines with care towards minimizing uncertainties in biologic assays as well as physical parameters. In this study we describe a novel high-throughput experimental setup and an optimized parameterization of the Monte Carlo (MC) simulation technique that is universally applicable for accurate determination of RBE of clinical ion beams...
September 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28872250/forschungspreis-zur-f%C3%A3-rderung-der-experimentellen-dermatologie-deutsche-dermatologische-gesellschaft-verleiht-oscar-gans-preis
#16
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28872230/deutsches-nationales-krebshilfe-monitoring-2015-2019-studienprotokoll-und-erste-ergebnisse
#17
Sven Schneider, Tatiana Görig, Laura Schilling, Eckhard W Breitbart, Rüdiger Greinert, Katharina Diehl
HINTERGRUND UND ZIELE: Das Projekt "Nationales Krebshilfe-Monitoring zur Solariennutzung" (National Cancer Aid Monitoring of Tanning Bed Use, NCAM) ist eine deutsche Großstudie mit dem Ziel, die wichtigsten Risikofaktoren für Hautkrebs zu beobachten: natürliches Sonnenlicht und künstliche UV-Strahlung. TEILNEHMER UND METHODEN: NCAM ist eine bundesweite Querschnittstudie mit zunächst vier Runden der Datenerfassung (sogenannten Wellen) zwischen 2015 und 2018...
September 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28871922/development-and-significance-of-the-e-surveillance-system-for-contact-allergies-in-slovenia
#18
Aleksandra Dugonik, Maja Kalač Pandurovič, Marko Vok, Bogdan Dugonik
This paper describes the development and significance of online systems for the collection and analysis of medical data (patch test results) with a web application. Modern digital tools greatly aid in collecting, combining, and preserving the data in a way that is friendly, undemanding and time-efficient for the dermatologist. Creating a central database for the results of patch testing provides a better picture of contact sensitivity and characteristics of allergic contact dermatitis in Slovenia. An electronic database and connected network was started in Slovenia in 2010...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28870525/rectal-balloon-use-limits-vaginal-displacement-rectal-dose-and-rectal-toxicity-in-patients-receiving-imrt-for-postoperative-gynecological-malignancies
#19
Cheng-Chia Wu, Yen-Ruh Wuu, Theodore Yanagihara, Ashish Jani, Eric P Xanthopoulos, Akhil Tiwari, Jason D Wright, William M Burke, June Y Hou, Ana I Tergas, Israel Deutsch
Pelvic radiotherapy for gynecologic malignancies traditionally used a 4-field box technique. Later trials have shown the feasibility of using intensity-modulated radiotherapy (IMRT) instead. But vaginal movement between fractions is concerning when using IMRT due to greater conformality of the isodose curves to the target and the resulting possibility of missing the target while the vagina is displaced. In this study, we showed that the use of a rectal balloon during treatment can decrease vaginal displacement, limit rectal dose, and limit acute and late toxicities...
September 1, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28868253/relationships-between-regional-radiation-doses-and-cognitive-decline-in-children-treated-with-cranio-spinal-irradiation-for-posterior-fossa-tumors
#20
Elodie Doger de Speville, Charlotte Robert, Martin Perez-Guevara, Antoine Grigis, Stephanie Bolle, Clemence Pinaud, Christelle Dufour, Anne Beaudré, Virginie Kieffer, Audrey Longaud, Jacques Grill, Dominique Valteau-Couanet, Eric Deutsch, Dimitri Lefkopoulos, Catherine Chiron, Lucie Hertz-Pannier, Marion Noulhiane
Pediatric posterior fossa tumor (PFT) survivors who have been treated with cranial radiation therapy often suffer from cognitive impairments that might relate to IQ decline. Radiotherapy (RT) distinctly affects brain regions involved in different cognitive functions. However, the relative contribution of regional irradiation to the different cognitive impairments still remains unclear. We investigated the relationships between the changes in different cognitive scores and radiation dose distribution in 30 children treated for a PFT...
2017: Frontiers in Oncology
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