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https://www.readbyqxmd.com/read/28209796/mammalian-heart-regeneration-the-race-to-the-finish-line
#1
Stefanie A Doppler, Marcus-Andre Deutsch, Vahid Serpooshan, Guang Li, Elda Dzilic, Rüdiger Lange, Markus Krane, Sean M Wu
No abstract text is available yet for this article.
February 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28207594/using-high-technology-simulators-to-prepare-anesthesia-providers-before-implementation-of-a-new-electronic-health-record-module-a-technical-report
#2
Ari Y Weintraub, Ellen S Deutsch, Roberta L Hales, Newton A Buchanan, Whitney L Rock, Mohamed A Rehman
Learning to use a new electronic anesthesia information management system can be challenging. Documenting anesthetic events, medication administration, and airway management in an unfamiliar system while simultaneously caring for a patient with the vigilance required for safe anesthesia can be distracting and risky. This technical report describes a vendor-agnostic approach to training using a high-technology manikin in a simulated clinical scenario. Training was feasible and valued by participants but required a combination of electronic and manual components...
February 15, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28205311/management-of-cardiovascular-risk-factors-in-patients-with-anca-associated-vasculitis
#3
Carsten Paul Bramlage, Juliane Kröplin, Manuel Wallbach, Joan Minguet, Katherine Helen Smith, Stephan Lüders, Joachim Schrader, Susan Patschan, Oliver Gross, Cornelia Deutsch, Peter Bramlage, Gerhard Anton Müller, Michael Koziolek
OBJECTIVES: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is accompanied by increased cardiovascular (CV) risk. Treatment of AAV patients includes the management of conventional CV risk factors, primarily hypertension and hypercholesterolemia, while lipoprotein(a) (LP(a)) is an emerging potential target. METHODS: We performed a multicenter, retrospective study in Germany. Patients were considered if they were between 18 and 90 years old and presented with AAV...
February 16, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28192072/persistence-of-zika-virus-in-breast-milk-after-infection-in-late-stage-of-pregnancy
#4
José R Sotelo, Andre B Sotelo, Fabio J B Sotelo, André M Doi, Joao R R Pinho, Rita de Cassia Oliveira, Alanna M P S Bezerra, Alice D Deutsch, Lucy S Villas-Boas, Alvina C Felix, Camila M Romano, Clarisse M Machado, Maria C J Mendes-Correa, Rubia A F Santana, Fernando G Menezes, Cristovao L P Mangueira
We detected Zika virus in breast milk of a woman in Brazil infected with the virus during the 36th week of pregnancy. Virus was detected 33 days after onset of signs and symptoms and 9 days after delivery. No abnormalities were found during fetal assessment or after birth of the infant.
May 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28183812/new-guidelines-for-publication-of-manuscripts-describing-development-and-application-of-targeted-mass-spectrometry-measurements-of-peptides-and-proteins
#5
Susan E Abbatiello, Bradley L Ackermann, Christoph H Borchers, Ralph A Bradshaw, Steven A Carr, Robert J Chalkley, Meena Choi, Eric W Deutsch, Bruno Domon, Andrew N Hoofnagle, Hasmik Keshishian, Eric Kuhn, Daniel C Liebler, Michael J MacCoss, Brendan MacLean, D R Mani, Hendrik Neubert, Derek Smith, Olga Vitek, Lisa Zimmerman
Molecular & Cellular Proteomics is pleased to announce new guidelines and requirements for papers describing the development and application of targeted mass spectrometry measurements of peptides, modified peptides and proteins. These guidelines will be implemented for papers submitted starting June, 2017.
February 9, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28174295/optimizing-local-control-in-high-grade-uterine-sarcoma-adjuvant-vaginal-vault-brachytherapy-as-part-of-a-multimodal-treatment
#6
Pierre Annede, Sébastien Gouy, Renaud Mazeron, Enrica Bentivegna, Pierre Maroun, Claire Petit, Isabelle Dumas, Alexandra Leary, Catherine Genestie, Catherine Lhommé, Eric Deutsch, Philippe Morice, Patricia Pautier, Christine Haie-Meder, Cyrus Chargari
PURPOSE: The phase III European Organization for Research and Treatment of Cancer 55874 study has shown that external beam radiotherapy (EBRT) given as adjuvant treatment decreased locoregional recurrences from 40% to 20% in patients (pts) with localized uterine sarcomas (US). No data exist, however, on the place of brachytherapy (BT). MATERIAL AND METHODS: We conducted a single-center retrospective analysis of pts receiving adjuvant BT of the vaginal vault based on the vaginal mold technique as part of their multimodal adjuvant treatment for a high-grade US from 1985 to 2015...
February 7, 2017: Oncologist
https://www.readbyqxmd.com/read/28168275/promises-and-challenges-for-the-implementation-of-computational-medical-imaging-radiomics-in-oncology
#7
E J Limkin, R Sun, L Dercle, E I Zacharaki, C Robert, S Reuzé, A Schernberg, N Paragios, E Deutsch, C Ferté
No abstract text is available yet for this article.
February 7, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28166638/the-peptideatlas-of-the-domestic-laying-hen
#8
James McCord, Zhi Sun, Eric W Deutsch, Robert L Moritz, David C Muddiman
Proteomics-based biological research is greatly expanded by high-quality mass spectrometry studies, which are themselves enabled by access to quality mass spectrometry resources, such as high-quality curated proteome data repositories. We present a PeptideAtlas for the domestic chicken, containing an extensive and robust collection of chicken tissue and plasma samples with substantial value for the chicken proteomics community for protein validation and design of downstream targeted proteome quantitation. The chicken PeptideAtlas contains 6646 canonical proteins at a protein FDR of 1...
February 14, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28162086/adult-adhd-is-associated-with-gambling-severity-and-psychiatric-comorbidity-among-treatment-seeking-problem-gamblers
#9
Laura Brandt, Gabriele Fischer
OBJECTIVE: The aim of this study is as follows: (a) exploring retrospective childhood and adult ADHD symptomatology in treatment-seeking gamblers, (b) providing detailed characteristics of the association between pathological gambling (PG) and ADHD, and (c) identifying risk factors for a history of ADHD. METHOD: Eighty problem gamblers (20% female) were examined using a standardized interview (PG: Diagnostic and Statistical Manual of Mental Disorders [4th ed.; DSM-IV] criteria, Gambling Attitudes and Beliefs Survey; ADHD: Wender Utah Rating Scale- deutsche Kurzform, Adult ADHD Self-Report Scale; comorbidities: Mini International Neuropsychiatric Interview)...
February 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28161341/a-rhythm-revealed-transient-brugada-pattern
#10
Julie Shelton, Bennet George, Christian Deutsch, Alison Bailey
No abstract text is available yet for this article.
February 1, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28160122/-guidelines-from-the-dog-rg-and-bva-retinal-artery-occlusion-november-2016-status
#11
(no author information available yet)
No abstract text is available yet for this article.
February 3, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28159148/hormonal-and-surgical-treatment-options-for-transgender-women-and-transfeminine-spectrum-persons
#12
REVIEW
Linda M Wesp, Madeline B Deutsch
Transgender women and other transfeminine spectrum people may pursue hormonal and/or surgical gender-affirming interventions. Hormone therapy includes androgen blockade and estrogen supplementation. Approaches to hormone treatment vary widely based on patient goals and physiology. Surgical procedures are available, including genital affirmation surgery, breast augmentation, and head or neck feminization procedures. Many people are unable to obtain surgeries owing to prohibitive costs and long waiting lists...
March 2017: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28152716/documentation-of-pharmacist-provided-patient-education-for-oral-chemotherapy
#13
Neeta K Venepalli, Patrick Joseph Fleming, Christina Haaf, Adam Bursua, Little Irene Park, Sandra Cuellar
: 237 Background: Pharmacist-provided patient education for oral chemotherapy is poorly documented in patient electronic medical records (EMR) at UIC Oncology Pharmacy. At baseline, 41% of patients who started new therapy with selected oral chemotherapies had a patient education note documented by a pharmacist in their EMR. Our aim is to provide and document patient education for at least 90% of patients who start new oral chemotherapy and fill their prescriptions at UIC Oncology Pharmacy over three months...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28149707/virucidal-efficacy-of-a-sonicated-hydrogen-peroxide-system-trophon-%C3%A2-epr-following-european-and-german-test-methods
#14
Britta Becker, Birte Bischoff, Florian H H Brill, Eike Steinmann, Jochen Steinmann
Aim: The virucidal efficacy of an automated ultrasound probe disinfector (trophon(®) EPR) was evaluated in a three step procedure according to European and German test methods. This system uses sonicated hydrogen peroxide mist (35%) at elevated temperature (50°C) in a closed chamber with control of all parameters within a 7 minute cycle. Methods: In the first step of examination, the peroxide solution was tested in a quantitative suspension assay according to the Guideline of Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten (DVV) e...
2017: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/28144738/-transorbital-alternating-current-in-optic-neuropathy-december-2016-opinion-of-the-dog-and-bva-on-gall%C3%A2-c-et%C3%A2-al-alternating-current-stimulation-for-vision-restoration-after-optic-nerve-damage-a%C3%A2-randomized-clinical-trial-plos-one-2016
#15
(no author information available yet)
No abstract text is available yet for this article.
January 31, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28141703/intraoperative-monitoring-of-analgesia-using-nociceptive-reflexes-correlates-with-delayed-extubation-and-immediate-postoperative-pain-a-prospective-observational-study
#16
Axel Jakuscheit, Johannes Weth, Gregor Lichtner, Carlo Jurth, Benno Rehberg, Falk von Dincklage
BACKGROUND: Immediate postoperative pain could be prevented by the administration of long-lasting analgesics before the end of the anaesthesia. However, to prevent over or underdosing of analgesics under anaesthesia, tools are required to estimate the analgesia-nociception balance. OBJECTIVE: We investigated whether the pupillary dilation reflex (PDR) and the nociceptive flexion reflex (NFR) at the end of general anaesthesia correlate with immediate postoperative pain, as a sign of analgesic underdosing, and with delayed tracheal extubation as a sign of analgesic overdosing...
January 30, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28140536/einsatz-und-wirksamkeit-von-systemtherapien-bei-erwachsenen-mit-schwerer-neurodermitis-erste-ergebnisse-des-deutschen-neurodermitis-registers-treatgermany
#17
Jochen Schmitt, Susanne Abraham, Freya Trautmann, Victoria Stephan, Regina Fölster-Holst, Bernhard Homey, Thomas Bieber, Natalija Novak, Michael Sticherling, Matthias Augustin, Andreas Kleinheinz, Peter Elsner, Stephan Weidinger, Thomas Werfel
HINTERGRUND: Versorgungsregister dienen der Erfassung des Einsatzes und der Wirksamkeit von Therapien unter realen Versorgungsbedingungen und sind als Basis einer evidenzbasierten Gesundheitsversorgung unverzichtbar. METHODIK: Das deutsche Neurodermitis-Register TREATgermany wurde als weltweit erstes Register für Patienten mit schwerer Neurodermitis 2011 initiiert. Erwachsene mit schwerer Neurodermitis (aktuelle/frühere antientzündliche Systemtherapie und/oder objektiver SCORAD ≥ 40) werden über einen Zeitraum von 24 Monaten prospektiv beobachtet...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28135259/building-proteometools-based-on-a-complete-synthetic-human-proteome
#18
Daniel P Zolg, Mathias Wilhelm, Karsten Schnatbaum, Johannes Zerweck, Tobias Knaute, Bernard Delanghe, Derek J Bailey, Siegfried Gessulat, Hans-Christian Ehrlich, Maximilian Weininger, Peng Yu, Judith Schlegl, Karl Kramer, Tobias Schmidt, Ulrike Kusebauch, Eric W Deutsch, Ruedi Aebersold, Robert L Moritz, Holger Wenschuh, Thomas Moehring, Stephan Aiche, Andreas Huhmer, Ulf Reimer, Bernhard Kuster
We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography-tandem mass spectrometry analysis of >330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at http://www.proteometools.org) will be extended to >1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange...
January 30, 2017: Nature Methods
https://www.readbyqxmd.com/read/28133993/a-healthy-diet-optimal-sleep-lifestyle-pattern-is-inversely-associated-with-liver-stiffness-and-insulin-resistance-in-patients-with-nonalcoholic-fatty-liver-disease
#19
Christina N Katsagoni, George V Papatheodoridis, Maria-Vasiliki Papageorgiou, Panagiota Ioannidou, Melanie Deutsch, Alexandra Alexopoulou, Nikolaos Papadopoulos, Elisabeth Fragopoulou, Meropi D Kontogianni
Several lifestyle habits have been described as risk factors for nonalcoholic fatty liver disease (NAFLD). Given that both healthy and unhealthy habits tend to cluster, the aim of this study was to identify lifestyle patterns and explore their potential associations with clinical characteristics of individuals with NAFLD. One hundred and thirty-six consecutive patients with ultrasound-proven NAFLD were included. Diet and physical activity level were assessed through appropriate questionnaires. Habitual night sleep hours and duration of midday naps were recorded...
November 8, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28129654/time-dependent-modulation-of-tumor-radiosensitivity-by-a-pan-hdac-inhibitor-abexinostat
#20
Sofia Rivera, Céline Leteur, Frédérique Mégnin, Frédéric Law, Isabelle Martins, Ioana Kloos, Stéphane Depil, Nazanine Modjtahedi, Jean Luc Perfettini, Christophe Hennequin, Eric Deutsch
Despite prominent role of radiotherapy in lung cancer management, there is an urgent need for strategies increasing therapeutic efficacy. Reversible epigenetic changes are promising targets for combination strategies using HDAC inhibitors (HDACi).Here we evaluated on two NSCLC cell lines, the antitumor effect of abexinostat, a novel pan HDACi combined with irradiation in vitro in normoxia and hypoxia, by clonogenic assays, demonstrating that abexinostat enhances radiosensitivity in a time dependent way with mean SER10 between 1...
January 25, 2017: Oncotarget
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