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https://www.readbyqxmd.com/read/28522277/-immunotherapy-and-radiotherapy
#1
S Bockel, D Antoni, É Deutsch, F Mornex
Radiotherapy, primarily known for its cytotoxic effect on the tumor cells, via the induction of DNA damages, has the ability to induce a systemic antitumoral response. By an immunologic cell death, tumor cells exposed to radiation release a large amount of neoantigenes and pro-inflammatory mediators, acting as an in situ vaccine, resulting in an tumor regression within the primary irradiated site, but also in the distant "out of field" secondary tumors. However, this phenomenon is extremly rare with radiotherapy alone, suggesting that the radiation-induced antitumor immunity is not sufficient for overcoming the tumor's and its microenvironnement immunosuppressing effect...
May 15, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28521923/safety-and-efficacy-of-transcatheter-aortic-valve-replacement-in-the-treatment-of-pure-aortic-regurgitation-in-native-valves-and-failing-surgical-bioprostheses-results-from-an-international-registry-study
#2
Fadi J Sawaya, Marcus-André Deutsch, Moritz Seiffert, Sung-Han Yoon, Pablo Codner, Upul Wickramarachchi, Azeem Latib, A Sonia Petronio, Josep Rodés-Cabau, Maurizio Taramasso, Marco Spaziano, Johan Bosmans, Luigi Biasco, Darren Mylotte, Mikko Savontaus, Peter Gheeraert, Jason Chan, Troels H Jørgensen, Horst Sievert, Marco Mocetti, Thierry Lefèvre, Francesco Maisano, Antonio Mangieri, David Hildick-Smith, Ran Kornowski, Raj Makkar, Sabine Bleiziffer, Lars Søndergaard, Ole De Backer
OBJECTIVES: The aim of this study was to evaluate the use of transcatheter heart valves (THV) for the treatment of noncalcific pure native aortic valve regurgitation (NAVR) and failing bioprosthetic surgical heart valves (SHVs) with pure severe aortic regurgitation (AR). BACKGROUND: Limited data are available about the "off-label" use of transcatheter aortic valve replacement (TAVR) to treat pure severe AR. METHODS: The study population consisted of patients with pure severe AR treated by TAVR at 18 different centers...
May 22, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28521376/-images-of-ageing-in-health-care-magazines-of-the-public-health-system
#3
Ilse Hartmann-Tews, Theresa Hoppe
Objectives Collective images of ageing influence attitudes towards ageing and health- related activities. The aim of this study was to explore images of ageing and old age in magazines published by public health institutions, namely health insurance companies and pharmacies. Design A standardized content analysis was conducted covering age-related articles (n=146) and accompanying photographs (n=218) of public health institutions. The stock of material comprises age-related articles of all magazines published 2012-2013 of 2 public health insurance companies (Allgemeine Ortskrankenkasse: "Bleib gesund", Barmer Ersatzkasse: "Gesundheit konkret"), 2 private health insurance companies (Gothaer Versicherung: "Gothaer magazin", Deutsche Krankenversicherung: "DKV impulse") and 2 consumer magazines of pharmacies ("Apothekenumschau","Senioren Ratgeber")...
May 18, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28515314/the-mzidentml-data-standard-version-1-2-supporting-advances-in-proteome-informatics
#4
Juan Antonio Vizcaíno, Gerhard Mayer, Simon R Perkins, Harald Barsnes, Marc Vaudel, Yasset Perez-Riverol, Tobias Ternent, Julian Uszkoreit, Martin Eisenacher, Lutz Fischer, Juri Rappsilber, Eugen Netz, Mathias Walzer, Oliver Kohlbacher, Alexander Leitner, Robert J Chalkley, Fawaz Ghali, Salvador Martínez-Bartolomé, Eric W Deutsch, Andrew R Jones
The first stable version of the Proteomics Standards Initiative mzIdentML open data standard (version 1.1) was published in 2012 - capturing the outputs of peptide and protein identification software. In the intervening years, the standard has become well supported in both commercial and open software, as well as a submission and download format for public repositories. Here we report a new release of mzIdentML (version 1.2) that is required to keep pace with emerging practice in proteome informatics. New features have been added to support: (i) scores associated with localization of modifications on peptides; (ii) statistics performed at the level of peptides; (iii) identification of cross-linked peptides; and (iv) support for proteogenomics approaches...
May 17, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28502313/preventing-binge-drinking-in-adolescents
#5
Reiner Hanewinkel, Samuel Tomczyk, Michaela Goecke, Barbara Isensee
BACKGROUND: In a survey taken in Germany in 2015, 14.1% of the 12- to 17-year-olds surveyed had practiced binge drinking at least once in the preceding 30 days. The school program "Klar bleiben" ("Keep a Clear Head") was designed for and implemented among 10th graders. The participants committed themselves to abstain from binge drinking for 9 weeks. We studied whether this intervention influenced the frequency and intensity of binge drinking. METHODS: This cluster-randomized controlled trial was carried out in 196 classes of 61 schools, with a total of 4163 participants with a mean age of 15...
April 21, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28501419/brachytherapy-for-conservative-treatment-of-invasive-penile-carcinoma-prognostic-factors-and-long-term-analysis-of-outcome
#6
Alexandre Escande, Christine Haie-Meder, Renaud Mazeron, Pierre Maroun, Andrea Cavalcanti, Renaud de Crevoisier, Antoine Schernberg, Fanny Marsolat, Pierre Blanchard, Florent Martinetti, Alberto Bossi, Isabelle Dumas, Eric Deutsch, Cyrus Chargari
PURPOSE: To report the largest experience with brachytherapy as a conservative approach for the treatment of penile carcinoma. METHODS AND MATERIALS: We examined the outcomes of 201 patients treated at our institution over 45 years for invasive squamous cell carcinoma of the glans penis by brachytherapy. RESULTS: With a median follow-up of 10.7 years, local relapse as first failure was reported in 37 patients (18.9%), and 24 of 31 patients (77...
February 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28498198/development-of-a-risk-adjustment-model-for-the-inpatient-rehabilitation-facility-discharge-self-care-functional-status-quality-measure
#7
Anne Deutsch, Poonam Pardasaney, Jeniffer Iriondo-Perez, Melvin J Ingber, Kristie A Porter, Tara McMullen
BACKGROUND: Functional status measures are important patient-centered indicators of inpatient rehabilitation facility (IRF) quality of care. We developed a risk-adjusted self-care functional status measure for the IRF Quality Reporting Program. This paper describes the development and performance of the measure's risk-adjustment model. METHODS: Our sample included IRF Medicare fee-for-service patients from the Centers for Medicare & Medicaid Services' 2008-2010 Post-Acute Care Payment Reform Demonstration...
May 11, 2017: Medical Care
https://www.readbyqxmd.com/read/28498118/particle-separation-from-road-runoff-by-a-decentralised-lamella-system-laboratory-tests-and-experiences-in-the-field
#8
J Fettig, V Pick, H Liebe
A new decentralised settling system based on the principle of lamella separation was developed for the treatment of road runoff. Two different laboratory test methods, the DIBt (Deutsches Institut für Bautechnik) procedure and our own approach, were applied in order to evaluate the efficiency of the system based on the separation of fine mineral particles and a mixture of mineral and organic particles, respectively. Overall efficiencies (88% after DIBt and 61% according to our own method) were comparable to results obtained for commercial systems...
May 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28488056/-choosing-wisely-recommendations-in-intensive-care-medicine
#9
REVIEW
R Riessen, S Kluge, U Janssens, H Kierdorf, K F Bodmann, H-J Busch, S John, M Möckel
Intensive care medicine is an important and integral part of internal medicine. Modern intensive care medicine permits survival of many patients with severe and life-threatening internal diseases in acute situations. Decisive for therapeutic success is often not the application of complicated and expensive medical technologies, but rather the rapid diagnosis and identification of core issues, with immediate and competent initiation of standard treatment regimens. An adequately staffed, well-organized interprofessional team is of central importance...
May 9, 2017: Der Internist
https://www.readbyqxmd.com/read/28488055/-choosing-wisely-recommendations-in-nephrology
#10
REVIEW
J Galle, J Floege
The German Society of Internal Medicine ("Deutsche Gesellschaft für Innere Medizin", DGIM) founded the Choosing wisely initiative in order to address diagnostic and therapeutic procedures that are frequently inappropriately applied, whether this be in terms of over-, under-, or misuse of health services. The German Society of Nephrology ("Deutsche Gesellschaft für Nephrologie," DGfN) strongly supports the initiative and has contributed five positive and five negative recommendations. These ten recommendations are discussed in the current publication...
May 9, 2017: Der Internist
https://www.readbyqxmd.com/read/28486464/discovering-and-linking-public-omics-data-sets-using-the-omics-discovery-index
#11
Yasset Perez-Riverol, Mingze Bai, Felipe da Veiga Leprevost, Silvano Squizzato, Young Mi Park, Kenneth Haug, Adam J Carroll, Dylan Spalding, Justin Paschall, Mingxun Wang, Noemi Del-Toro, Tobias Ternent, Peng Zhang, Nicola Buso, Nuno Bandeira, Eric W Deutsch, David S Campbell, Ronald C Beavis, Reza M Salek, Ugis Sarkans, Robert Petryszak, Maria Keays, Eoin Fahy, Manish Sud, Shankar Subramaniam, Ariana Barbera, Rafael C Jiménez, Alexey I Nesvizhskii, Susanna-Assunta Sansone, Christoph Steinbeck, Rodrigo Lopez, Juan A Vizcaíno, Peipei Ping, Henning Hermjakob
No abstract text is available yet for this article.
May 9, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28483649/effect-of-nascent-peptide-steric-bulk-on-elongation-kinetics-in-the-ribosome-exit-tunnel
#12
Pengse Po, Erin Delaney, Howard Gamper, Miklos Szanti-Kis, Lee Speight, LiWei Tu, Andrey Kosolapov, E James Petersson, Ya-Ming Hou, Carol Deutsch
All proteins are synthesized by the ribosome, a macromolecular complex that accomplishes the life-sustaining tasks of faithfully decoding mRNA and catalyzing peptide bond formation at the peptidyl transferase center (PTC). The ribosome has evolved an exit tunnel to host the elongating new peptide, protect it from proteolytic digestion, and guide its emergence. It is here that the nascent chain begins to fold. This folding process depends on the rate of translation at the PTC. We report here that, besides PTC events, translation kinetics depend on steric constraints on nascent peptide side chains, and that confined movements of cramped side chains within and through the tunnel fine-tune elongation rates...
May 5, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28482371/guidelines-for-the-treatment-of-head-injury-in-adults
#13
R Firsching, E Rickels, U M Mauer, O W Sakowitz, M Messing-Jünger, K Engelhard, P Schwenkreis, J Linn, K Schwerdtfeger
The workshop of scientific medical faculties (Arbeitsgemeinschaft wissenschaftlicher medizinischer Fakultäten [AWMF]) of Germany has asked societies of specific medical disciplines to jointly publish guidelines on the treatment of diseases and injuries. On behalf of the Deutsche Gesellschaft für Neurochirurgie, its commission on guidelines initiated an interdisciplinary approach to publish guidelines on the treatment of head injury in adults. These guidelines were published in German by the AWMF in late 2015...
May 8, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28476723/ethics-considerations-in-global-mobile-phone-based-surveys-of-noncommunicable-diseases-a-conceptual-exploration
#14
Joseph Ali, Alain B Labrique, Kara Gionfriddo, George Pariyo, Dustin G Gibson, Bridget Pratt, Molly Deutsch-Feldman, Adnan A Hyder
Mobile phone coverage has grown, particularly within low- and middle-income countries (LMICs), presenting an opportunity to augment routine health surveillance programs. Several LMICs and global health partners are seeking opportunities to launch basic mobile phone-based surveys of noncommunicable diseases (NCDs). The increasing use of such technology in LMICs brings forth a cluster of ethical challenges; however, much of the existing literature regarding the ethics of mobile or digital health focuses on the use of technologies in high-income countries and does not consider directly the specific ethical issues associated with the conduct of mobile phone surveys (MPS) for NCD risk factor surveillance in LMICs...
May 5, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28470442/erratum-to-validation-of-the-custo-screen-pediatric-blood-pressure-monitor-according-to-the-european-society-of-hypertension-international-protocol-revision-2010
#15
Beate Beime, Cornelia Deutsch, Ralf Krüger, Andreas Wolf, Peter Müller, Gertrud Hammel, Peter Bramlage
No abstract text is available yet for this article.
May 4, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28470028/high-power-growth-robust-ingaas-inalas-terahertz-quantum-cascade-lasers
#16
Christoph Deutsch, Martin Alexander Kainz, Michael Krall, Martin Brandstetter, Dominic Bachmann, Sebastian Schönhuber, Hermann Detz, Tobias Zederbauer, Donald MacFarland, Aaron Maxwell Andrews, Werner Schrenk, Mattias Beck, Keita Ohtani, Jérôme Faist, Gottfried Strasser, Karl Unterrainer
We report on high-power terahertz quantum cascade lasers based on low effective electron mass InGaAs/InAlAs semiconductor heterostructures with excellent reproducibility. Growth-related asymmetries in the form of interface roughness and dopant migration play a crucial role in this material system. These bias polarity dependent phenomena are studied using a nominally symmetric active region resulting in a preferential electron transport in the growth direction. A structure based on a three-well optical phonon depletion scheme was optimized for this bias direction...
April 19, 2017: ACS Photonics
https://www.readbyqxmd.com/read/28464934/study-protocol-of-the-german-study-on-tobacco-use-debra-a-national-household-survey-of-smoking-behaviour-and-cessation
#17
Sabrina Kastaun, Jamie Brown, Leonie S Brose, Elena Ratschen, Tobias Raupach, Dennis Nowak, Constanze Cholmakow-Bodechtel, Lion Shahab, Robert West, Daniel Kotz
BACKGROUND: The prevalence of tobacco smoking in Germany is high (~27%). Monitoring of national patterns of smoking behaviour and data on the "real-world" effectiveness of cessation methods are needed to inform policies and develop campaigns aimed at reducing tobacco-related harm. In England, the Smoking Toolkit Study (STS) has been tracking such indicators since 2006, resulting in the adaptation of tobacco control policies. However, findings cannot be directly transferred into the German health policy context...
May 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28464911/impact-of-high-intensity-niv-on-the-heart-in-stable-copd-a-randomised-cross-over-pilot-study
#18
Marieke Leontine Duiverman, Petra Maagh, Friederike Sophie Magnet, Claudia Schmoor, Maria Paola Arellano-Maric, Axel Meissner, Jan Hendrik Storre, Peter Jan Wijkstra, Wolfram Windisch, Jens Callegari
BACKGROUND: Although high-intensity non-invasive ventilation has been shown to improve outcomes in stable COPD, it may adversely affect cardiac performance. Therefore, the aims of the present pilot study were to compare cardiac and pulmonary effects of 6 weeks of low-intensity non-invasive ventilation and 6 weeks of high-intensity non-invasive ventilation in stable COPD patients. METHODS: In a randomised crossover pilot feasibility study, the change in cardiac output after 6 weeks of each NIV mode compared to baseline was assessed with echocardiography in 14 severe stable COPD patients...
May 2, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28463219/-possible-paradoxical-reaction-to-treatment-of-tubercular-meningitis-in-an-hiv-negative-patient
#19
Ana C Rey Deutsch, Luz M Curi Dasso, José Stringa, Sebastián Grinspon, Mariano Volpachio, Octavio Mazzocchi
The paradoxical response to tuberculosis treatment consists in the appearance of new clinical or radiologic manifestations or worsening of previous injuries after an initial improvement with anti-tuberculosis therapy. It can be observed in 6 to 30 percent of the cases of tubercular meningitis. It is the consequence of an exaggerated immune reaction that should be considered since the treatment is based on the use of immunomodulators and not in the change of anti-tuberculous drugs. We present the case of an HIV negative adult with tuberculous meningitis with a good initial response to specific therapy who showed, 10 weeks later, a paradoxical reaction to treatment that responded successfully to corticosteroids...
2017: Medicina
https://www.readbyqxmd.com/read/28463154/brachytherapy-combined-with-surgery-for-conservative-treatment-of-children-with-bladder-neck-and-or-prostate-rhabdomyosarcoma
#20
Cyrus Chargari, Christine Haie-Meder, Florent Guérin, Véronique Minard-Colin, Guénolée de Lambert, Renaud Mazeron, Alexandre Escande, Fanny Marsolat, Isabelle Dumas, Eric Deutsch, Dominique Valteau-Couanet, Georges Audry, Odile Oberlin, Hélène Martelli
PURPOSE: To report the results of a conservative strategy based on partial surgery combined with brachytherapy in a prospective cohort of children with bladder-prostate rhabdomyosarcoma (BP RMS). METHODS AND MATERIALS: We prospectively documented the outcome of children treated in our department between 1991 and 2015 for BP RMS and undergoing a multimodal approach combining conservative surgery (partial cystectomy and/or partial prostatectomy) and perioperative interstitial low-dose-rate or pulse-dose-rate brachytherapy...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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