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https://www.readbyqxmd.com/read/28810956/the-reasons-for-living-scale-military-version-assessing-protective-factors-against-suicide-in-a-military-sample
#1
Anne-Marie Deutsch, R Gregory Lande
INTRODUCTION: Military suicide rates have been rising over the past decade and continue to challenge military treatment facilities. Assessing suicide risk and improving treatments are a large part of the mission for clinicians who work with uniformed service members. This study attempts to expand the toolkit of military suicide prevention by focusing on protective factors over risk factors. In 1983, Marsha Linehan published a checklist called the Reasons for Living Scale, which asked subjects to check the reasons they choose to continue living, rather than choosing suicide...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28802813/evaluating-hospital-readmission-rates-after-discharge-from-inpatient-rehabilitation
#2
Laura Coots Daras, Melvin J Ingber, Jessica Carichner, Daniel Barch, Anne Deutsch, Laura M Smith, Alan Levitt, Joel Andress
OBJECTIVE: To examine facility-level rates of all-cause, unplanned hospital readmissions for 30 days following discharge from inpatient rehabilitation facilities (IRFs). DESIGN: Using an observational design, we analyzed Medicare claims in order to develop an all-cause, risk-adjusted hospital readmission measure. SETTING: We used national Medicare inpatient claims and enrollment data for Medicare beneficiaries who were discharged from IRFs in 2013-2014 and met specific inclusion criteria (1,166 IRFs)...
August 9, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28801764/zentrale-aspekte-zur-durchf%C3%A3-hrung-und-indikationsstellung-der-ivom
#3
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28801575/limits-of-radiomic-based-entropy-as-a-surrogate-of-tumor-heterogeneity-roi-area-acquisition-protocol-and-tissue-site-exert-substantial-influence
#4
Laurent Dercle, Samy Ammari, Mathilde Bateson, Paul Blanc Durand, Eva Haspinger, Christophe Massard, Cyril Jaudet, Andrea Varga, Eric Deutsch, Jean-Charles Soria, Charles Ferté
Entropy is a promising quantitative imaging biomarker for characterizing cancer imaging phenotype. Entropy has been associated with tumor gene expression, tumor metabolism, tumor stage, patient prognosis, and treatment response. Our hypothesis states that tumor-specific biomarkers such as entropy should be correlated between synchronous metastases. Therefore, a significant proportion of the variance of entropy should be attributed to the malignant process. We analyzed 112 patients with matched/paired synchronous metastases (SM#1 and SM#2) prospectively enrolled in the MOSCATO-01 clinical trial...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801345/molecular-basis-for-increased-susceptibility-of-indigenous-north-americans-to-seropositive-rheumatoid-arthritis
#5
Stephen W Scally, Soi-Cheng Law, Yi Tian Ting, Jurgen van Heemst, Jeremy Sokolove, Aaron J Deutsch, E Bridie Clemens, Antonis K Moustakas, George K Papadopoulos, Diane van der Woude, Irene Smolik, Carol A Hitchon, David B Robinson, Elizabeth D Ferucci, Charles N Bernstein, Xiaobo Meng, Vidyanand Anaparti, Tom Huizinga, Katherine Kedzierska, Hugh H Reid, Soumya Raychaudhuri, René E Toes, Jamie Rossjohn, Hani El-Gabalawy, Ranjeny Thomas
OBJECTIVE: The pathogenetic mechanisms by which HLA-DRB1 alleles are associated with anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) are incompletely understood. RA high-risk HLA-DRB1 alleles are known to share a common motif, the 'shared susceptibility epitope (SE)'. Here, the electropositive P4 pocket of HLA-DRB1 accommodates self-peptide residues containing citrulline but not arginine. HLA-DRB1 His/Phe13β stratifies with ACPA-positive RA, while His13βSer polymorphisms stratify with ACPA-negative RA and RA protection...
August 11, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28800767/cell-adhesion-heterogeneity-reinforces-tumour-cell-dissemination-novel-insights-from-a-mathematical-model
#6
David Reher, Barbara Klink, Andreas Deutsch, Anja Voss-Böhme
BACKGROUND: Cancer cell invasion, dissemination, and metastasis have been linked to an epithelial-mesenchymal transition (EMT) of individual tumour cells. During EMT, adhesion molecules like E-cadherin are downregulated and the decrease of cell-cell adhesion allows tumour cells to dissociate from the primary tumour mass. This complex process depends on intracellular cues that are subject to genetic and epigenetic variability, as well as extrinsic cues from the local environment resulting in a spatial heterogeneity in the adhesive phenotype of individual tumour cells...
August 11, 2017: Biology Direct
https://www.readbyqxmd.com/read/28800657/qualit%C3%A3-tssicherung-der-optischen-koh%C3%A3-renztomografie-f%C3%A3-r-die-diagnostik-des-augenhintergrunds
#7
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28799112/the-dgav-risk-calculator-development-and-validation-of-statistical-models-for-a-web-based-instrument-predicting-complications-of-colorectal-cancer-surgery
#8
Alexander Crispin, Carsten Klinger, Anna Rieger, Brigitte Strahwald, Kai Lehmann, Heinz-Johannes Buhr, Ulrich Mansmann
PURPOSE: The purpose of this study is to provide a web-based calculator predicting complication probabilities of patients undergoing colorectal cancer (CRC) surgery in Germany. METHODS: Analyses were based on records of first-time CRC surgery between 2010 and February 2017, documented in the database of the Study, Documentation, and Quality Center (StuDoQ) of the Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV), a registry of CRC surgery in hospitals throughout Germany, covering demography, medical history, tumor features, comorbidity, behavioral risk factors, surgical procedures, and outcomes...
August 10, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28798251/lungmap-the-molecular-atlas-of-lung-development-program
#9
Maryanne E Ardini-Poleske, Robert Fred Clark, Charles Ansong, James P Carson, Richard A Corley, Gail H Deutsch, James S Hagood, Naftali Kaminski, Thomas J Mariani, Steven S Potter, Gloria S Pryhuber, David Warburton, Jeffrey A Whitsett, Scott M Palmer, Namasivayam Ambalavanan, The LungMAP Consortium
The National Heart Lung and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic crosstalk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis and injury repair. A better understanding of the processes that regulate lung development, particularly alveologenesis, will have significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults...
August 10, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28776654/the-latency-complex-the-dead-hand-of-anti-development
#10
Barry D Proner
It is common knowledge that the same phenomena can be viewed in a variety of ways. This paper considers the implications of a constellation observed in some adult patients who have increasingly reminded the author of some of the children of latency age with whom he has also worked. In the literature these patients may also have been thought about in terms of 'defences of the self' (Fordham), patients who are 'difficult to reach' (Joseph), 'psychic retreats' (Steiner), and those who make 'attacks on linking' (Bion)...
September 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28771576/prospective-evaluation-of-a-patented-dna-test-for-canine-hip-dysplasia-chd
#11
Eberhard Manz, Bernd Tellhelm, Michael Krawczak
Genetic testing has been propagated as a suitable means to specify individual risks for canine hip dysplasia (CHD). However, the current lack of validation of most genetic CHD tests has left dog owners and breeders in the dark about their practical utility. Therefore, the Society for German Shepherd Dogs (Verein für Deutsche Schäferhunde, SV) initiated a prospective study of 935 animals to assess independently the value of a genetic CHD test (European Patent Specification EP 2 123 777 B1) that was developed by Distl et al...
2017: PloS One
https://www.readbyqxmd.com/read/28768111/providing-pediatric-palliative-care-education-using-problem-based-learning
#12
Karen Moody, Marlene McHugh, Rebecca Baker, Hillel Cohen, Priya Pinto, Stephanie Deutsch, Ruth O Santizo, Miriam Schechter, James Fausto, Pablo Joo
BACKGROUND: The Institute of Medicine and the American Academy of Pediatrics has called for improvement in education and training of pediatricians in pediatric palliative care (PPC). Given the shortage of PPC physicians and the immediate need for PPC medical education, this study reports the outcomes of a problem-based learning (PBL) module facilitated by academic general and subspecialty pediatric faculty (non-PPC specialists) to third year medical students. Objectives/Setting: To test the effectiveness of a PPC-PBL module on third year medical students' and pediatric faculty's declarative knowledge, attitudes toward, perceived exposure, and self-assessed competency in PPC objectives...
August 2, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28760484/pulsed-dose-rate-brachytherapy-for-pediatric-bladder-prostate-rhabdomyosarcoma-compliance-and-early-clinical-results
#13
Cyrus Chargari, Hélène Martelli, Florent Guérin, Warren Bacorro, Guénolée de Lambert, Alexandre Escande, Véronique Minard-Colin, Isabelle Dumas, Eric Deutsch, Christine Haie-Meder
OBJECTIVE: No data are available on the feasibility of pulsed dose rate (PDR) brachytherapy in very young children. Our experience of PDR brachytherapy for bladder prostate (BP) rhabdomyosarcoma (RMS) is reported, with focus on compliance and dosimetric parameters. MATERIALS AND METHODS: Treatment parameters and outcome of consecutive BP RMS patients treated in our center were examined. Treatment was carried out as part of a multimodal conservative radio-surgical treatment...
July 28, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28750299/prolonged-activation-of-the-coagulation-system-during-in-vitro-fertilization-cycles
#14
Yoni Cohen, Togas Tulandi, Benny Almog, Eyal Zohav, Varda Deutsch, Ariel Many, Ami Amit, Aviad Cohen
OBJECTIVE: To investigate coagulation system changes during an in-vitro fertilization (IVF) cycle using Thromboelastogram (TEG) that enables analysis of the elastic properties of whole blood samples and provides a global assessment of the hemostatic function. STUDY DESIGN: A prospective study. TEG indices were evaluated in 23 women who underwent controlled ovarian stimulation for IVF at four points in time: 1. At the beginning of the cycle (corresponding to the lowest levels of E2), 2...
July 17, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28743612/clinical-outcomes-after-interstitial-brachytherapy-for-early-stage-nasal-squamous-cell-carcinoma
#15
Warren Bacorro, Alexandre Escande, Stéphane Temam, Isabelle Dumas, Emilie Routier, Marie-Catherine Gensse, Pierre Blanchard, François Janot, Christine Mateus, Yungan Tao, Caroline Robert, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
PURPOSE: Radiotherapy of nasal carcinomas results in cure rates comparable to surgery, with anatomic preservation and good cosmesis. Brachytherapy (BT) overcomes difficulties with dosimetric coverage and affords a localized and highly conformal irradiation. We report our experience of BT for early-stage nasal squamous cell carcinomas (SCCs). METHODS AND MATERIALS: Clinical data, BT parameters, and outcome of consecutive patients treated by interstitial BT in our institute between December 1982 and April 2015 for a localized nasal SCC were examined...
July 22, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28739455/decision-making-in-critical-limb-ischemia-a-markov-simulation
#16
Aaron J Deutsch, C Charles Jain, Kimberly G Blumenthal, Mark W Dickinson, Anne M Neilan
BACKGROUND: Critical limb ischemia (CLI) is a feared complication of peripheral vascular disease that often requires surgical management and may require amputation of the affected limb. OBJECTIVE: To use a decision model to inform clinical management for a 63-year-old woman with CLI and multiple medical comorbidities, including advanced heart failure and diabetes. METHODS: Markov decision model evaluating four strategies: amputation, surgical bypass, endovascular therapy (e...
July 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28726545/the-t-6-a-modification-acts-as-a-positive-determinant-for-the-anticodon-nuclease-prrc-and-is-distinctively-nonessential-in-streptococcus-mutans
#17
Jo Marie Bacusmo, Silvia S Orsini, Jennifer Hu, Michael DeMott, Patrick C Thiaville, Ameer Elfarash, Mellie June Paulines, Diego Rojas-Benítez, Birthe Meineke, Chris Deutsch, Dirk Iwata-Reuyl, Patrick A Limbach, Peter C Dedon, Kelly C Rice, Stewart Shuman, Valérie de Crécy-Lagard
Endoribonuclease toxins (ribotoxins) are produced by bacteria and fungi to respond to stress, eliminate non-self competitor species, or interdict virus infection. PrrC is a bacterial ribotoxin that targets and cleaves tRNA(Lys)UUU in the anticodon loop. In vitro studies suggested that the post-transcriptional modification threonylcarbamoyl adenosine (t(6)A) is required for PrrC activity but this prediction had never been validated in vivo. Here, by using t(6)A-deficient yeast derivatives, it is shown that t(6)A is a positive determinant for PrrC proteins from various bacterial species...
July 20, 2017: RNA Biology
https://www.readbyqxmd.com/read/28710686/-ophthalmological-assessment-in-the-severely-handicapped-persons-act-and-in-blindness-statement-of-the-professional-association-of-ophthalmologists-germany-the-german-ophthalmological-society-processed-by-the-joint-commission-on-law-status-january-2017
#18
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
July 14, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28696878/asynchronous-pumping-of-a-pulsatile-ventricular-assist-device-in-a-pediatric-anastomosis-model
#19
Bryan C Good, William J Weiss, Steven Deutsch, Keefe B Manning
BACKGROUND: Both pulsatile and continuous flow ventricular assist devices are being developed for pediatric congenital heart defect patients. Pulsatile devices are often operated asynchronously with the heart in either an "automatic" or a fixed beat rate mode. However, most studies have only investigated synchronized ejection. METHODS: A previously validated viscoelastic blood solver is used to investigate the parameters of pulsatility, power loss, and graft failure in a pediatric aortic anastomosis model...
July 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28693852/using-simulation-to-improve-systems
#20
REVIEW
James A Kearney, Ellen S Deutsch
Attempts to understand and improve health care delivery often focus on the characteristics of the patient and the characteristics of the health care providers, but larger systems surround and integrate with patients and providers. Components of health care delivery systems can support or interfere with efforts to provide optimal health care. Simulation in situ, involving real teams participating in simulations in real care settings, can be used to identify latent safety threats and improve the work environment while simultaneously supporting participant learning...
July 7, 2017: Otolaryngologic Clinics of North America
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