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https://www.readbyqxmd.com/read/29642588/crystal-structure-of-the-isocitrate-dehydrogenase-2-from-acinetobacter-baumannii-abidh2-reveals-a-novel-dimeric-structure-with-two-monomeric-idh-like-subunits
#1
Peng Wang, Yatao Wu, Jie Liu, Ping Song, Shan Li, Xinxin Zhou, Guoping Zhu
Monomeric isocitrate dehydrogenases (IDHs) have a single polypeptide sizing around 85 kDa. The IDH2 from the opportunistic bacterium Acinetobacter baumannii (AbIDH2) with a mass of 83 kDa was formerly recognized as a typical monomeric IDH. However, both size exclusion chromatography and analytical ultracentrifugation analysis indicated that AbIDH2 exists as a homodimer in solution. The crystallographic study of the substrate/coenzyme-free AbIDH2 gave a dimeric structure and each subunit contained a domain I and a domain II...
April 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29606787/exposure-to-predators-reduces-collective-foraging-aggressiveness-and-eliminates-its-relationship-with-colony-personality-composition
#2
Colin M Wright, James L L Lichtenstein, Graham A Montgomery, Lauren P Luscuskie, Noa Pinter-Wollman, Jonathan N Pruitt
Predation is a ubiquitous threat that often plays a central role in determining community dynamics. Predators can impact prey species by directly consuming them, or indirectly causing prey to modify their behavior. Direct consumption has classically been the focus of research on predator-prey interactions, but substantial evidence now demonstrates that the indirect effects of predators on prey populations are at least as strong as, if not stronger than, direct consumption. Social animals, particularly those that live in confined colonies, rely on coordinated actions that may be vulnerable to the presence of a predator, thus impacting the society's productivity and survival...
August 2017: Behavioral Ecology and Sociobiology
https://www.readbyqxmd.com/read/29590601/do-skeletal-dynamics-mediate-sugar-uptake-and-transport-in-human-erythrocytes
#3
Robert J Asaro, Qiang Zhu, Pedro Cabrales, Anthony Carruthers
We explore, herein, the hypothesis that transport of molecules or ions into erythrocytes may be affected and directly stimulated by the dynamics of the spectrin/actin skeleton. Skeleton/actin motions are driven by thermal fluctuations that may be influenced by ATP hydrolysis as well as by structural alterations of the junctional complexes that connect the skeleton to the cell's lipid membrane. Specifically, we focus on the uptake of glucose into erythrocytes via glucose transporter 1 and on the kinetics of glucose disassociation at the endofacial side of glucose transporter 1...
March 27, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29589912/%C3%AE-cyclodextrin-reverses-binding-of-perfluorooctanoic-acid-to-human-serum-albumin
#4
Mary Jo Weiss-Errico, Jaroslava Miksovska, Kevin E O'Shea
Perfluorooctanoic acid (PFOA), a persistent organic pollutant known to cause adverse health effects, strongly binds to human serum albumin (HSA). β-Cyclodextrin (β-CD), a non-toxic cyclic sugar, strongly complexes PFOA in a host-guest complex, and has been proposed for environmental remediation of PFOA. The interactions between HSA, PFOA, and β-CD were investigated in order to determine if β-CD can reverse the binding of PFOA to HSA, with potential therapeutic applications towards exposure to PFOA.19 F Nuclear magnetic resonance (NMR), circular dichroism, and fluorescence spectroscopies were used to study these interactions...
March 28, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29572368/complication-of-intraprosthetic-dislocation-of-dual-mobility-hip-implant-following-closed-reduction
#5
Navin Mukundu Nagesh, Nimesh Patel, Jonathan Howell
Total hip replacement is a successful operation for the management of hip pain but there are potential complications, of which dislocation is one of the most common. The management of recurrent dislocation is a challenging problem that requires a multimodal approach and the use of dual-mobility implants is one option. We present a patient who was previously revised with a dual-mobility implant for recurrent dislocation, who had a complication after closed reduction of a subsequent intraprosthetic dislocation...
March 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29570982/using-ramp-incremental-v%C3%AC-o2-responses-for-constant-intensity-exercise-selection
#6
Daniel A Keir, Donald H Paterson, John M Kowalchuk, Juan M Murias
Despite compelling evidence to the contrary, the view that oxygen uptake (V̇O2) increases linearly with exercise intensity (e.g. power output, speed) until reaching its maximum (V̇O2max) persists within the exercise physiology literature. This viewpoint implies that the V̇O2 response at any constant-intensity is predictable from a ramp-incremental exercise test. However, the V̇O2 versus task-specific exercise intensity relationship constructed from ramp-incremental versus constant-intensity exercise are not equivalent preventing the use of V̇O2 responses from one domain to predict those of the other...
March 23, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29561032/significance-of-dna-bond-strength-in-programmable-nanoparticle-thermodynamics-and-dynamics
#7
Qiuyan Yu, Jinglei Hu, Yi Hu, Rong Wang
Assembly of nanoparticles (NPs) coated with complementary DNA strands leads to novel crystals with nanosized basic units rather than classic atoms, ions or molecules. The assembly process is mediated by hybridization of DNA via specific base pairing interaction, and is kinetically linked to the disassociation of DNA duplexes. DNA-level physiochemical quantities, both thermodynamic and kinetic, are key to understanding this process and essential for the design of DNA-NP crystals. The melting transition properties are helpful to judge the thermostability and sensitivity of relative DNA probes or other applications...
March 21, 2018: Soft Matter
https://www.readbyqxmd.com/read/29560395/intraoperative-femoral-head-dislodgement-during-total-hip-arthroplasty-a-report-of-four-cases
#8
Ahmed Siddiqi, Carl T Talmo, James V Bono
Dislodgment of trial femoral heads and migration into the pelvis during total hip arthroplasty is a rarely reported complication with limited published cases. There are three primary mechanisms of femoral head separation: dislodgement during reduction attempt, disassociation from anterior dislocation while assessing anterior stability, and during dislocation after implant trialing. If the trial femoral migrates beyond the pelvic brim, it is safer to finish the total hip arthroplasty and address the retained object after repositioning or in a planned second procedure with a general surgeon...
March 2018: Arthroplasty Today
https://www.readbyqxmd.com/read/29554477/improved-sandwich-format-electrochemical-immunosensor-based-on-smart-sio-2-polydopamine-nanocarrier
#9
Dongsheng Zhang, Weixiang Li, Zhanfang Ma
An improved sandwich-type electrochemical immunosensor based on the novel signal amplification strategy was developed. Methylene blue (MB) loaded mesoporous silica nanoparticles (MSN) with polydopamine coating (PDA) were employed as "smart" labels, while phytic acid doped polyaniline hydrogel (PANI) with high adsorption capacity was acted as substrate. In this strategy, amount of redox species (MB) encapsulated in MSN by PDA will be released under acidic condition and then absorbed stably by PANI...
March 13, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29553500/a-mouse-model-of-orthopedic-surgery-to-study-postoperative-cognitive-dysfunction-and-tissue-regeneration
#10
Chao Xiong, Zhiquan Zhang, Gurpreet S Baht, Niccolo Terrando
Surgery is commonly used to improve and maintain quality of life. Unfortunately, in vulnerable patients such as the elderly, complications may occur and significantly diminish the outcome. Indeed, after routine orthopedic surgery to repair a fracture, as many as 50% of elderly patients suffer from neurologic complications like delirium. Also, the capacity to heal and regenerate tissue after surgery decreases with age, and can impact the quality of fracture repair and even osseous integration of implants. Thus, a better understanding of mechanisms that drive these age-dependent changes could provide strategic targets to minimize risk for such complications and optimize outcomes...
February 27, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29532178/use-of-psychophysiological-portable-devices-to-analyse-stress-response-in-different-experienced-soldiers
#11
J F Tornero-Aguilera, José Juan Robles-Pérez, Vicente Javier Clemente-Suárez
Previous studies have shown that actuate stress have a negative effect on working memory, visio-spatial ability and symptoms of disassociation. We conducted the present research with the aim of to analyse the effect of experience and training in psychophysiological response, attention and memory of soldiers in combat. Variables of blood lactate, blood glucose, blood oxygen saturation, body temperature, heart rate, lower body muscular strength manifestation, autonomic modulation, cortical arousal, cognitive and somatic anxiety, and memory by a post mission questionnaire were analysed before and after a combat simulation in 49 soldiers of Spanish Army...
March 12, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29525317/short-communication-lysine-retained-among-2-lipid-coated-lysine-products-after-exposure-to-alfalfa-or-corn-silage-with-different-amounts-of-acidity
#12
J N Reiners, J E Held, C L Wright, D W Brake
We conducted 2 experiments to determine lysine loss from 2 lipid-coated lysine products after mixing with silage. In our first experiment, we mixed 2 lipid-coated lysine products, crystalline lysine or crystalline lysine and amounts of lipid identical to amounts included in lipid-coated lysine products, with alfalfa or corn silage that had 2 different amounts of acidity. Lysine appeared to disassociate from lipid-coated lysine products in a nonlinear manner after mixing with either alfalfa or corn silage at different amounts of acidity...
March 7, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29519690/music-enjoyment-with-cochlear-implantation
#13
REVIEW
Charlotte Prevoteau, Stephanie Y Chen, Anil K Lalwani
Since the advent of cochlear implant (CI) surgery in the 1960s, there have been remarkable technological and surgical advances enabling excellent speech perception in quiet with many CI users able to use the telephone. However, many CI users struggle with music perception, particularly with the pitch-based and melodic elements of music. Yet remarkably, despite poor music perception, many CI users enjoy listening to music based on self-report questionnaires, and prospective studies have suggested a disassociation between music perception and enjoyment...
March 5, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29516722/pegylated-self-assembled-nano-bacitracin-a-probing-the-antibacterial-mechanism-and-real-time-tracing-of-target-delivery-in-vivo
#14
Wei Hong, Yining Zhao, Yuru Guo, Chengcheng Huang, Peng Qiu, Jia Zhu, Chun Chu, Hong Shi, Mingchun Liu
Although nano-self-assemblies of hydrophobic-modified bacitracin A with PLGA (Nano-BAPLGA) have demonstrated promising antibacterial activities, the application of Nano-BAPLGA was severely compromised by low water solubility. In this study, a series of PEGylated PLGA copolymers were selected to conjugate the N-terminus of bacitracin A in order to construct PEGylated self-assembled Nano-BAs and to further develop nano-self-assemblies of bacitracin A with strong antibacterial potency and high solubility. Compared with Nano-BAPLGA, all PEGylated Nano-BAs, except Nano-BA5K, exhibited strong antibacterial efficiency against both gram-positive and gram-negative bacteria by inducing loss of cytoplasmic membrane potential, membrane permeabilization and leakage of calcein from artificial cell membranes...
March 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29515840/modification-of-wheat-gluten-for-improvement-of-binding-capacity-with-keratin-in-hair
#15
Shukun Wang, Danyang Meng, Sisi Wang, Zhong Zhang, Ruijin Yang, Wei Zhao
In this study, enzymatic hydrolysis and cationization with epoxypropyldodecyldimethylammonium chloride of wheat protein, an economic protein complex containing great amount of disulfide bonds, were conducted to improve properties such as solubility and disassociation behaviour for recovery of damaged hair when used in shampoo. The optimal conditions for enzymatic hydrolysis were pH 8.2, 55°C with Alcalase for 60 min. After the selected hydrolysis, the degree of hydrolysis, nitrogen solubility index, foaming capacity index, foam stability index, emulsifying activity index and emulsion stability index of hydrolysate with 58...
February 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29490279/usp2a-supports-metastasis-by-tuning-tgf-%C3%AE-signaling
#16
Yin Zhao, Xiaomeng Wang, Qingqing Wang, Yu Deng, Kang Li, Man Zhang, Qiang Zhang, Jin Zhou, Hong-Yan Wang, Peng Bai, Yujie Ren, Ni Zhang, Weina Li, Yongbo Cheng, Wuhan Xiao, Hai-Ning Du, Xiaoliang Cheng, Lei Yin, Xiangning Fu, Dandan Lin, Qianghui Zhou, Bo Zhong
TGF-β has been demonstrated to promote tumor metastasis, and the regulatory mechanisms are poorly understood. Here, we report the role of USP2a in promoting metastasis by facilitating TGF-β-triggered signaling. USP2a interacts with TGFBR1 and TGFBR2 upon TGF-β stimulation and removes K33-linked polyubiquitin chains from Lys502 of TGFBR1, promoting the recruitment of SMAD2/3. Simultaneously, TGFBR2 phosphorylates Ser207/Ser225 of USP2a, leading to the disassociation of SMAD2/3 from TGFBR1. The phosphorylation of USP2a and SMAD2 is positively correlated in human tumor biopsies, and USP2a is hyper-phosphorylated in lung adenocarcinomas with lymph node invasion...
February 27, 2018: Cell Reports
https://www.readbyqxmd.com/read/29480812/thermoswitchable-catalysis-controlled-by-reversible-dispersion-aggregation-change-of-nanoreactors-in-the-presence-of-%C3%AE-cd-polymers
#17
Yinfeng Li, Jie Hu, Chengrong Niu, Jinghang Leng, Songjun Li
The present work was aimed at preparing a thermosensitive nanoreactor system which could adjust its dispersion/aggregation status according to external temperature change to achieve the switchable catalysis. The mesoporous silica nanoparticle(MSNP) was selected as the framework material of the nanoreactor, and Ag nanoparticles were encapsulated in the mesoporous silica by an in situ reaction. Dodecyl groups were introduced onto mesoporous silica nanoparticle surface, which could transform reversibly between complexation and disassociation with α-cyclodextrin(CD) cavity upon temperature change...
February 26, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29463890/iron-and-phosphorus-deprivation-induce-sociality-in-the-marine-bloom-forming-cyanobacterium-trichodesmium
#18
Yael Tzubari, Liel Magnezi, Avraham Be'er, Ilana Berman-Frank
Trichodesmium spp. are diazotrophic cyanobacteria that exist as single filaments (trichomes) and as macroscopic colonies of varying shapes formed by aggregating trichomes. The causes and dynamics of colony formation and disassociation are not yet elucidated. we demonstrate that limited availability of dissolved phosphorus (P) or iron (Fe) stimulated trichome mobility and induced colony formation in Trichodesmium erythraeum IMS101 cultures. The specific nutrient limitation differentially affected the rate of colony formation and morphology of the colonies...
February 20, 2018: ISME Journal
https://www.readbyqxmd.com/read/29461288/carbon-monoxide-and-cyanide-poisoning-in-the-burned-pregnant-patient-an-indication-for-hyperbaric-oxygen-therapy
#19
Derek M Culnan, Beretta Craft-Coffman, Genevieve H Bitz, Karel D Capek, Yiji Tu, William C Lineaweaver, Maggie J Kuhlmann-Capek
Carbon monoxide (CO) is a small molecule poison released as a product of incomplete combustion. Carbon monoxide binds hemoglobin, reducing oxygen delivery. This effect is exacerbated in the burned pregnant patient by fetal hemoglobin that binds CO 2.5- to 3-fold stronger than maternal hemoglobin. With no signature clinical symptom, diagnosis depends on patient injury history, elevated carboxyhemoglobin levels, and alterations in mental status. The standard of care for treatment of CO intoxication is 100% normobaric oxygen, which decreases the half-life of CO in the bloodstream from 5 hours to 1 hour...
March 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29458212/programmed-drug-delivery-system-based-on-optimized-size-decrease-and-hydrophilicity-hydrophobicity-transformation-for-enhanced-hepatocellular-carcinoma-therapy-of-doxorubicin
#20
Yuanyuan Liu, Lian Li, Lijia Li, Zhou Zhou, Fengling Wang, Xiaofeng Xiong, Rui Zhou, Yuan Huang
Requirements on drug delivery systems to surmount a complex series of pathophysiological barriers bear "cascading contradictions", especially size and hydrophilicity/hydrophobicity contradiction. Herein, a programmed drug delivery system (GNPs-Dox-Lac) based on optimized "size decrease and hydrophilicity/hydrophobicity transformation" was developed by combination the gelatin nanoparticle (GNPs) and prodrug Doxorubicin-Lactose (Dox-Lac). The results showed that GNPs-Dox-Lac (133.3 nm) were kinetically stable in blood circulation and inclined to accumulate at the tumor site...
February 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
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