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https://www.readbyqxmd.com/read/29035037/controlling-superwettability-by-microstructure-and-surface-energy-manipulation-on-three-dimensional-substrates-for-versatile-gravity-driven-oil-water-separation
#1
Hao-Yang Mi, Xin Jing, Han-Xiong Huang, Lih-Sheng Turng
Superwettable materials have gained tremendous attention because of their special wetting abilities. The key to obtaining and tuning superwettability is to precisely control the interfacial microstructures and surface energies of materials. Herein, we propose a novel approach to controlling the superwettability of three-dimensional foams. The surface microstructure was manipulated by the layer-by-layer covalent grafting of multidimensional nanoparticles (e.g., silica, carbon nanotubes, and graphene oxide), and the surface energy was tailored by grafting chemicals with different functional groups...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29024529/catalytic-conductive-bipolar-membrane-interfaces-via-layer-by-layer-deposition-for-the-design-of-membrane-integrated-artificial-photosynthesis-systems
#2
Michael B McDonald, Michael Freund, Paula T Hammond
In the presence of an electric field, bipolar membranes (BPMs) are capable of initiating water disassociation (WD) within the interfacial region, which can make water splitting for renewable energy in the presence of a pH gradient possible. In addition to WD catalytic efficiency, there is also need for electronic conductivity in this region for membrane-integrated artificial photosynthesis (AP) systems. Graphene oxide (GO) has been shown to catalyze WD and to be controllably reduced resulting in electronic conductivity...
October 10, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28980690/rational-design-of-food-grade-polyelectrolyte-complex-coacervate-for-encapsulation-and-enhanced-oral-delivery-of-oenothein-b
#3
Yaqi Lan, Li Wang, Sufang Cao, Yinger Zhong, Yunqi Li, Yong Cao, Lichao Zhao
Oenothein B (OeB), a dimeric macrocyclic ellagitannin isolated from eucalyptus leaves has been demonstrated as a promising natural bioactive compound for its remarkable antitumor, antioxidant, anti-inflammatory and immunomodulating effects. Unfortunately, early study indicates that OeB has quite low bioaccessibility for oral consumption due to their susceptibility to decomposition both in vitro and in vivo. Herein, we report the design and synthesis of food-grade polyelectrolyte complex coacervate using caseinophosphopeptides (CPPs) and chitosan (CS) to encapsulate OeB for enhanced protection through gastrointestinal (GI) tract...
October 5, 2017: Food & Function
https://www.readbyqxmd.com/read/28977870/c-terminal-kinesin-motor-kifc1-participates-in-facilitating-proper-cell-division-of-human-seminoma
#4
Yu-Xi Xiao, Hao-Qing Shen, Zhen-Yu She, Li Sheng, Qian-Qian Chen, Yu-Lan Chu, Fu-Qing Tan, Wan-Xi Yang
C-terminus kinesin motor KIFC1 is known for centrosome clustering in cancer cells with supernumerary centrosomes. KIFC1 crosslinks and glides on microtubules (MT) to assist normal bipolar spindle formation to avoid multi-polar cell division, which might be fatal. Testis cancer is the most common human cancer among young men. However, the gene expression profiles of testis cancer is still not complete and the expression of the C-terminus kinesin motor KIFC1 in testis cancer has not yet been examined. We found that KIFC1 is enriched in seminoma tissues in both mRNA level and protein level, and is specifically enriched in the cells that divide actively...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976432/the-efficiency-of-bone-marrow-aspiration-for-the-harvest-of-connective-tissue-progenitors-from-the-human-iliac-crest
#5
Thomas E Patterson, Cynthia Boehm, Chizu Nakamoto, Richard Rozic, Esteban Walker, Nicolas S Piuzzi, George F Muschler
BACKGROUND: The rational design and optimization of tissue engineering strategies for cell-based therapy requires a baseline understanding of the concentration and prevalence of osteogenic progenitor cell populations in the source tissues. The aim of this study was to (1) define the efficiency of, and variation among individuals in, bone marrow aspiration as a means of osteogenic connective tissue progenitor (CTP-O) harvest compared with harvest from iliac cancellous bone, and (2) determine the location of CTP-Os within native cancellous bone and their distribution between the marrow-space and trabecular-surface tissue compartments...
October 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28975452/mathematical-modeling-for-estrogenic-activity-prediction-of-17%C3%AE-estradiol-and-17%C3%AE-ethynylestradiol-mixtures-in-wastewater-treatment-plants-effluent
#6
Yien Fang Ting, Sarva Mangala Praveena, Ahmad Zaharin Aris, Sharifah Norkhadijah Syed Ismail, Irniza Rasdi
Steroid estrogens such as 17β-Estradiol (E2) and 17α-Ethynylestradiol (EE2) are highly potent estrogens that widely detected in environmental samples. Mathematical modelling such as concentration addition (CA) and estradiol equivalent concentration (EEQ) models are usually associated with measuring techniques to assess risk, predict the mixture response and evaluate the estrogenic activity of mixture. Wastewater has played a crucial role because wastewater treatment plant (WWTP) is the major sources of estrogenic activity in aquatic environment...
October 3, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28973306/structure-based-investigation-on-the-binding-and-activation-of-typical-pesticides-with-thyroid-receptor
#7
Dandan Xiang, Jian Han, Tingting Yao, Qiangwei Wang, Bingsheng Zhou, Abou Donia Mohamed, Guonian Zhu
A broad range of pesticides have been reported to interfere with the normal function of the thyroid endocrine system. However, the precise mechanism(s) of action has not yet been thoroughly elucidated. In the present study, 21 pesticides were assessed for their binding interactions and the potential to disrupt thyroid homeostasis. In the GH3 luciferase reporter gene assays, 5 of the pesticides tested had agonistic effects in the order of procymidone > imidacloprid > mancozeb > fluroxypyr > atrazine...
August 31, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28973029/seasonal-variation-in-the-utility-of-a-status-signaling-system-plumage-ornament-predicts-foraging-success-only-during-periods-of-high-competition
#8
Philip S Queller, Troy G Murphy
Status signals allow competitors to assess each other's resource holding potential and reduce the occurrence of physical fights. Because status signals function to mediate competition over resources, a change in the strength of competition may affect the utility of a status signaling system. Status signals alter competitor behavior during periods of high competition, and thus determine access to resources; however, when competition is reduced, we expect these signals to become disassociated from access to resources...
2017: PloS One
https://www.readbyqxmd.com/read/28955982/therapeutic-potential-of-gw501516-and-the-role-of-peroxisome-proliferator-activated-receptor-%C3%AE-%C3%AE-and-b-cell-lymphoma-6-in-inflammatory-signaling-in-human-pancreatic-cancer-cells
#9
Russell W Smith, Jeffrey D Coleman, Jerry T Thompson, John P Vanden Heuvel
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a member of the nuclear receptor superfamily and a ligand-activated transcription factor that is involved in the regulation of the inflammatory response via activation of anti-inflammatory target genes and ligand-induced disassociation with the transcriptional repressor B-cell lymphoma 6 (BCL6). Chronic pancreatitis is considered to be a significant etiological factor for pancreatic cancer development, and a better understanding of the underlying mechanisms of the transition between inflammation and carcinogenesis would help further elucidate chemopreventative options...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28930995/stereotactic-atlas-guided-laser-capture-microdissection-of-brain-regions-affected-by-traumatic-injury
#10
Harris A Weisz, Deborah R Boone, Stacy L Sell, Helen L Hellmich
The ability to isolate specific brain regions of interest can be impeded in tissue disassociation techniques that do not preserve their spatial distribution. Such techniques also potentially skew gene expression analysis because the process itself can alter expression patterns in individual cells. Here we describe a laser capture microdissection (LCM) method to selectively collect specific brain regions affected by traumatic brain injury (TBI) by using a modified Nissl (cresyl violet) staining protocol and the guidance of a rat brain atlas...
September 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28916647/the-effect-of-common-inversion-polymorphisms-in-2l-t-and-in-3r-mo-on-patterns-of-transcriptional-variation-in-drosophila-melanogaster
#11
Erik Lavington, Andrew D Kern
Chromosomal inversions are an ubiquitous feature of genetic variation. Theoretical models describe several mechanisms by which inversions can drive adaptation and be maintained as polymorphisms. While inversions have been shown previously to be under selection, or contain genetic variation under selection, the specific phenotypic consequences of inversions leading to their maintenance remain unclear. Here we use genomic sequence and expression data from the Drosophila Genetic Reference Panel to explore the effects of two cosmopolitan inversions, In(2L)t and In(3R)Mo, on patterns of transcriptional variation...
September 15, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28890335/the-er-localized-transmembrane-protein-epg-3-vmp1-regulates-serca-activity-to-control-er-isolation-membrane-contacts-for-autophagosome-formation
#12
Yan G Zhao, Yong Chen, Guangyan Miao, Hongyu Zhao, Wenyan Qu, Dongfang Li, Zheng Wang, Nan Liu, Lin Li, She Chen, Pingsheng Liu, Du Feng, Hong Zhang
During autophagosome formation in mammalian cells, isolation membranes (IMs; autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER-localized metazoan-specific autophagy protein EPG-3/VMP1 controls ER-IM contacts. Loss of VMP1 causes stable association of IMs with the ER, thus blocking autophagosome formation. Interaction of WIPI2 with the ULK1/FIP200 complex and PI(3)P contributes to the formation of ER-IM contacts, and these interactions are enhanced by VMP1 depletion. VMP1 controls contact formation by promoting SERCA (sarco[endo]plasmic reticulum calcium ATPase) activity...
September 21, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28854727/effect-of-randomized-serum-progesterone-concentration-on-secretory-endometrial-histologic-development-and-gene-expression
#13
Steven L Young, Ricardo F Savaris, Bruce A Lessey, Andrew M Sharkey, Ursula Balthazar, Richard J Zaino, Robert A Sherwin, Marc A Fritz
STUDY QUESTION: What doses of secretory phase progesterone (P) in women are associated with altered endometrial structure and/or function? SUMMARY ANSWER: Consistently delayed histological maturation was seen at the lowest tested daily P dose (2.5 mg), whereas consistently altered functional response, as reflected by microarray analysis of gene expression was seen at both the 5 and 2.5 mg doses. WHAT IS KNOWN ALREADY: Progesterone is absolutely required for normal embryo implantation and pregnancy survival...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28831681/neddylation-antagonizes-ubiquitination-of-proliferating-cell-nuclear-antigen-and-regulates-the-recruitment-of-polymerase-%C3%AE-in-response-to-oxidative-dna-damage
#14
Junhong Guan, Shuyu Yu, Xiaofeng Zheng
NEDDylation has been shown to participate in the DNA damage pathway, but the substrates of neural precursor cell expressed developmentally downregulated 8 (NEDD8) and the roles of NEDDylation involved in the DNA damage response (DDR) are largely unknown. Translesion synthesis (TLS) is a damage-tolerance mechanism, in which RAD18/RAD6-mediated monoubiquitinated proliferating cell nuclear antigen (PCNA) promotes recruitment of polymerase η (polη) to bypass lesions. Here we identify PCNA as a substrate of NEDD8, and show that E3 ligase RAD18-catalyzed PCNA NEDDylation antagonizes its ubiquitination...
August 22, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28808033/multiplex-quantitative-cellular-analysis-in-large-tissue-volumes-with-clearing-enhanced-3d-microscopy-ce3d
#15
Weizhe Li, Ronald N Germain, Michael Y Gerner
Organ homeostasis, cellular differentiation, signal relay, and in situ function all depend on the spatial organization of cells in complex tissues. For this reason, comprehensive, high-resolution mapping of cell positioning, phenotypic identity, and functional state in the context of macroscale tissue structure is critical to a deeper understanding of diverse biological processes. Here we report an easy to use method, clearing-enhanced 3D (Ce3D), which generates excellent tissue transparency for most organs, preserves cellular morphology and protein fluorescence, and is robustly compatible with antibody-based immunolabeling...
August 29, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28801951/modeling-ion-recombination-in-liquid-ionization-chambers-improvement-and-analysis-of-the-two-dose-rate-method
#16
Jonas Andersson, Heikki Tölli
PURPOSE: The use of liquid ionization chambers can provide useful information to endeavors with radiation dosimetry for highly modulated beams. Liquid ionization chambers may be particularly suitable for computed tomography applications where conventional ionization chambers do not present a high enough sensitivity for the spatial resolution required to characterize common X-ray beams. Due to the sensitivity, which leads to high charge densities, liquid ionization chambers can suffer from large recombination losses leading to degradation in signal to dose rate linearity...
August 12, 2017: Medical Physics
https://www.readbyqxmd.com/read/28737172/selective-production-of-arenes-via-direct-lignin-upgrading-over-a-niobium-based-catalyst
#17
Yi Shao, Qineng Xia, Lin Dong, Xiaohui Liu, Xue Han, Stewart F Parker, Yongqiang Cheng, Luke L Daemen, Anibal J Ramirez-Cuesta, Sihai Yang, Yanqin Wang
Lignin is the only large-volume renewable source of aromatic chemicals. Efficient depolymerization and deoxygenation of lignin while retaining the aromatic functionality are attractive but extremely challenging. Here we report the selective production of arenes via direct hydrodeoxygenation of organosolv lignin over a porous Ru/Nb2O5 catalyst that enabled the complete removal of the oxygen content from lignin. The conversion of birch lignin to monomer C7-C9 hydrocarbons is nearly quantitative based on its monomer content, with a total mass yield of 35...
July 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28734758/atypical-interference-control-in-children-with-ad-hd-with-elevated-theta-beta-ratio
#18
Da-Wei Zhang, Steven Roodenrys, Hui Li, Robert J Barry, Adam R Clarke, Zhanliang Wu, Qihua Zhao, Yan Song, Lu Liu, Qiujin Qian, Yufeng Wang, Stuart J Johnstone, Li Sun
The theta/beta ratio (TBR) is a major area of interest within electroencephalogram (EEG) research in AD/HD. While researchers suggest a prognostic role for TBR in AD/HD, its relationship to behavior remains uncertain. Recent evidence suggests that elevated TBR in AD/HD may be related to atypical inhibition, particularly at an attentional level. This study aimed to examine the performance on three inhibitory tasks of children with AD/HD. Fifty-eight children with AD/HD participated, divided into an elevated TBR (ET) group and a control group (CT)...
September 2017: Biological Psychology
https://www.readbyqxmd.com/read/28712467/children-disassociate-from-antisocial-in-group-members
#19
Matti Wilks, Mark Nielsen
Extensive research has demonstrated that children show a robust in-group bias and, concurrently, are highly attuned to the prosocial and antisocial behavior of others. The limited research investigating the capacity for antisocial behavior to attenuate children's in-group bias has, however, returned mixed findings. Moreover, no research has examined how this might interact with perceived group permeability. Thus, the current study aimed to provide a more complete understanding of the relationship between in-group bias and antisocial behavior, how this interacts with perceptions of out-group behavior, and how group context (permeability) influences these responses...
July 13, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28710270/stabilization-of-multimeric-proteins-via-intersubunit-cyclization
#20
Lu Zhu, Shuwen Wang, Wenya Tian, Yeqi Zhang, Yang Song, Jun Zhang, Bo Mu, Chao Peng, Zixin Deng, Hongmin Ma, Xudong Qu
Proteins with high catalytic efficiency and selectivity under mild conditions have long been appreciated by industrial and medicinal fields. These proteins, which are commonly multimeric, often possess low stability, impeding wider application. Currently, strategies to improve the stability of multimeric proteins concentrate on enhancing the interaction at internal interface of the subunits. In this report, we confirmed that the largely underestimated subunit terminal ends are as significant as the internal interface for protein stability...
September 15, 2017: Applied and Environmental Microbiology
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