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JOURNAL ARTICLE
Alexandre Alanio, Hannah Marie Snell, Camille Cordier, Marie Desnos-Olivier, Sarah Dellière, Nesrine Aissaoui, Aude Sturny-Leclère, Elodie Da Silva, Cyril Eblé, Martine Rouveau, Micheline Thégat, Widad Zebiche, Matthieu Lafaurie, Blandine Denis, Sophie Touratier, Mourad Benyamina, Emmanuel Dudoignon, Samia Hamane, Christina A Cuomo, François Dépret
Candida auris is a recently described emerging pathogen in hospital settings. Five genetic clades have been delineated, with each clade being isolated from specific geographic regions. We here describe the first transmission between 2 patients (P0 and P1) of a clade I C. auris strain imported into our burn intensive care unit from the Middle East. The strains have been investigated with whole-genome sequencing, which validated the high similarity of the genomes between isolates from P0 and P1. We repeatedly screened the two patients and contact patients (i...
September 12, 2022: Microbiology Spectrum
#22
Marianne G De Maeseneer, Stavros K Kakkos, Thomas Aherne, Niels Baekgaard, Stephen Black, Lena Blomgren, Athanasios Giannoukas, Manjit Gohel, Rick de Graaf, Claudine Hamel-Desnos, Arkadiusz Jawien, Aleksandra Jaworucka-Kaczorowska, Christopher R Lattimer, Giovanni Mosti, Thomas Noppeney, Marie Josee van Rijn, Gerry Stansby, Philippe Kolh, Frederico Bastos Goncalves, Nabil Chakfé, Raphael Coscas, Gert J de Borst, Nuno V Dias, Robert J Hinchliffe, Igor B Koncar, Jes S Lindholt, Santi Trimarchi, Riikka Tulamo, Christopher P Twine, Frank Vermassen, Anders Wanhainen, Martin Björck, Nicos Labropoulos, Fedor Lurie, Armando Mansilha, Isaac K Nyamekye, Marta Ramirez Ortega, Jorge H Ulloa, Tomasz Urbanek, Andre M van Rij, Marc E Vuylsteke
No abstract text is available yet for this article.
2022: European Journal of Vascular and Endovascular Surgery
#23
JOURNAL ARTICLE
Alexandre Demoule, Muriel Fartoukh, Guillaume Louis, Elie Azoulay, Safaa Nemlaghi, Edouard Jullien, Cyrielle Desnos, Sebastien Clerc, Elise Yvin, Nouchan Mellati, Cyril Charron, Guillaume Voiriot, Yoann Picard, Antoine Vieillard-Baron, Michael Darmon
PURPOSE: To compare the characteristics, management, and prognosis of patients admitted to intensive care units (ICU) for coronavirus disease (COVID)-19 during the first two waves of the outbreak and to evaluate the relationship between ICU strain (ICU demand due to COVID-19 admissions) and mortality. METHODS: In a multicentre retrospective study, 1166 COVID-19 patients admitted to five ICUs in France between 20 February and 31 December 2020 were included. Data were collected at each ICU from medical records...
2022: PloS One
#24
JOURNAL ARTICLE
Cyrielle Desnos, Stéphane Ederhy, Pierre Belnou, Nathanaël Lapidus, Guillaume Lefevre, Guillaume Voiriot, Ariel Cohen, Muriel Fartoukh, Vincent Labbé
BACKGROUND: Identifying which patients with acute myocardial infarction (AMI) during sepsis are at risk of poor outcome is a clinical challenge. AIM: To evaluate Global Registry of Acute Coronary Events (GRACE) and Thrombolysis In Myocardial Infarction (TIMI) risk scores to predict in-hospital mortality and severe ischaemic events in this setting. METHODS: In this single-centre retrospective study conducted from 2012 to 2016, all consecutive adults hospitalized in the intensive care unit for sepsis who had a concomitant AMI (within 72hours of admission) were enrolled...
May 20, 2022: Archives of Cardiovascular Diseases
#25
JOURNAL ARTICLE
Chloé Loyer, Arnaud Lapostolle, Tomas Urbina, Alexandre Elabbadi, Jean-Rémi Lavillegrand, Thomas Chaigneau, Coraly Simoes, Julien Dessajan, Cyrielle Desnos, Mélanie Morin-Brureau, Yannick Chantran, Pierre Aucouturier, Bertrand Guidet, Guillaume Voiriot, Hafid Ait-Oufella, Carole Elbim
BACKGROUND: A dysregulated immune response is emerging as a key feature of critical illness in COVID-19. Neutrophils are key components of early innate immunity that, if not tightly regulated, contribute to uncontrolled systemic inflammation. We sought to decipher the role of neutrophil phenotypes, functions, and homeostasis in COVID-19 disease severity and outcome. METHODS: By using flow cytometry, this longitudinal study compares peripheral whole-blood neutrophils from 90 COVID-19 ICU patients with those of 22 SARS-CoV-2-negative patients hospitalized for severe community-acquired pneumonia (CAP) and 38 healthy controls...
May 30, 2022: Critical Care: the Official Journal of the Critical Care Forum
#26
JOURNAL ARTICLE
Léa Le Poder, Caroline Mercier, Laureline Février, Nathalie Duong, Pascale David, Sylvain Pluchon, Laurent Nussaume, Thierry Desnos
Aluminum (Al) is a major limiting factor for crop production on acidic soils, inhibiting root growth and plant development. At acidic pH (pH < 5.5), Al3+ ions are the main form of Al present in the media. Al3+ ions have an increased solubility at pH < 5.5 and result in plant toxicity. At higher pH, the free Al3+ fraction decreases in the media, but whether plants can detect Al at these pHs remain unknown. To cope with Al stress, the SENSITIVE TO PROTON RHIZOTOXICITY1 (STOP1) transcription factor induces AL-ACTIVATED MALATE TRANSPORTER1 ( ALMT1 ), a malate-exuding transporter as a strategy to chelate the toxic ions in the rhizosphere...
2022: Frontiers in Plant Science
#27
JOURNAL ARTICLE
Stéphane Bretagne, Karine Sitbon, Marie Desnos-Ollivier, Dea Garcia-Hermoso, Valérie Letscher-Bru, Sophie Cassaing, Laurence Millon, Florent Morio, Jean-Pierre Gangneux, Lilia Hasseine, Loïc Favennec, Estelle Cateau, Eric Bailly, Maxime Moniot, Julie Bonhomme, Nicole Desbois-Nogard, Taieb Chouaki, André Paugam, Bernard Bouteille, Marc Pihet, Frédéric Dalle, Odile Eloy, Milène Sasso, Magalie Demar, Patricia Mariani-Kurkdjian, Vincent Robert, Olivier Lortholary, Françoise Dromer
The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The incidence increased slightly over time (2.16 to 2.36/10,000 hospitalization days, P = 0.0562) in relation with an increase of fungemia incidence (1.03 to 1.19/10,000, P = 0.0023), while that of other IFDs remained stable...
June 28, 2022: MBio
#28
JOURNAL ARTICLE
Marie Desnos-Ollivier, Stéphane Bretagne, Olivier Lortholary, Françoise Dromer
Since echinocandins are recommended as first line therapy for invasive candidiasis, detection of resistance, mainly due to alteration in FKS protein, is of main interest. EUCAST AFST recommends testing both MIC of anidulafungin and micafungin, and breakpoints (BPs) have been proposed to detect echinocandin-resistant isolates. We analyzed MIC distribution for all three available echinocandins of 2,787 clinical yeast isolates corresponding to 5 common and 16 rare yeast species, using the standardized EUCAST method for anidulafungin and modified for caspofungin and micafungin (AM3-MIC)...
April 12, 2022: Antimicrobial Agents and Chemotherapy
#29
JOURNAL ARTICLE
Josephine Bilbao Bourke, Jordan Dobrovolny, Melanie Eaton, Theresa Ferrante, Megan Smith
INTRODUCTION: Sustained, developmentally adverse experiences in childhood put survivors at risk for posttraumatic stress disorder and impairments in biological, affective, cognitive, and intra/interpersonal domains. Complex trauma symptoms are often treated in isolation without addressing their common root cause. The trauma-focused phased Complex Trauma Care Pathway (CTCP) was developed to address this care gap. METHODS: We piloted the CTCP in 2 medical centers for 12 months among 46 therapist-referred adults...
May 19, 2021: Permanente Journal
#30
JOURNAL ARTICLE
Marianne G De Maeseneer, Stavros K Kakkos, Thomas Aherne, Niels Baekgaard, Stephen Black, Lena Blomgren, Athanasios Giannoukas, Manjit Gohel, Rick de Graaf, Claudine Hamel-Desnos, Arkadiusz Jawien, Aleksandra Jaworucka-Kaczorowska, Christopher R Lattimer, Giovanni Mosti, Thomas Noppeney, Marie Josee van Rijn, Gerry Stansby, Esvs Guidelines Committee, Philippe Kolh, Frederico Bastos Goncalves, Nabil Chakfé, Raphael Coscas, Gert J de Borst, Nuno V Dias, Robert J Hinchliffe, Igor B Koncar, Jes S Lindholt, Santi Trimarchi, Riikka Tulamo, Christopher P Twine, Frank Vermassen, Anders Wanhainen, Document Reviewers, Martin Björck, Nicos Labropoulos, Fedor Lurie, Armando Mansilha, Isaac K Nyamekye, Marta Ramirez Ortega, Jorge H Ulloa, Tomasz Urbanek, Andre M van Rij, Marc E Vuylsteke
No abstract text is available yet for this article.
February 2022: European Journal of Vascular and Endovascular Surgery
#31
JOURNAL ARTICLE
Simon Bourcier, Cyrielle Desnos, Marina Clément, Guillaume Hékimian, Nicolas Bréchot, Fabio Silvio Taccone, Mirko Belliato, Federico Pappalardo, Lars Mikael Broman, Maximilian Valentin Malfertheiner, Dirk Lunz, Matthieu Schmidt, Pascal Leprince, Alain Combes, Guillaume Lebreton, Charles-Edouard Luyt
BACKGROUND: Extracorporeal cardiopulmonary resuscitation (ECPR) is a rescue therapy for refractory cardiac arrest, but its high mortality has raised questions about patient selection. No selection criteria have been proposed for patients experiencing in-hospital cardiac arrest. We aimed to identify selection criteria available at the time ECPR was considered for patients with in-hospital cardiac arrest. We analyzed data of in-hospital cardiac arrest patients undergoing ECPR in our extracorporeal membrane oxygenation (ECMO) center (March 2007 to March 2019)...
March 1, 2022: International Journal of Cardiology
#32
JOURNAL ARTICLE
Janina Noster, Martin B Koeppel, Marie Desnos-Olivier, Maria Aigner, Oliver Bader, Karl Dichtl, Stephan Göttig, Andrea Haas, Oliver Kurzai, Arthur B Pranada, Yvonne Stelzer, Grit Walther, Axel Hamprecht
Magnusiomyces clavatus and Magnusiomyces capitatus are emerging yeasts with intrinsic resistance to many commonly used antifungal agents. Identification is difficult, and determination of susceptibility patterns with commercial and reference methods is equally challenging. For this reason, few data on invasive infections by Magnusiomyces spp. are available. Our objectives were to determine the epidemiology and susceptibility of Magnusiomyces isolates from bloodstream infections (BSI) isolated in Germany and Austria from 2001 to 2020...
February 15, 2022: Antimicrobial Agents and Chemotherapy
#33
JOURNAL ARTICLE
Laurent Nussaume, Thierry Desnos
No abstract text is available yet for this article.
November 20, 2021: Molecular Plant
#34
JOURNAL ARTICLE
Sarah Janati Idrissi, Daniel Le Bourhis, Antoine Lefevre, Patrick Emond, Laurene Le Berre, Olivier Desnoës, Thierry Joly, Samuel Buff, Sandrine Freret, Laurent Schibler, Pascal Salvetti, Sébastien Elis
Embryo lipid profile is affected by in vitro culture conditions, that lead to an increase in lipids. Efforts have been made to optimize embryo lipid composition as it is associated with their quality. The objective of this study was to evaluate whether the diet supplementation of donor cows (n-3 or n-6 PUFA), or the slow freezing protocols (ethylene glycol sucrose EG-S vs. glycerol trehalose GLY-TRE), or the physiological stage of the donor (nulliparous heifers vs. primiparous lactating cows) may impact the bovine embryo lipid profile...
October 29, 2021: Biology of Reproduction
#35
JOURNAL ARTICLE
Dong-Hoon Yang, Matthew R England, Helene Salvator, Seher Anjum, Yoon-Dong Park, Kieren A Marr, Laurie A Chu, Nelesh P Govender, Shawn R Lockhart, Marie Desnos-Ollivier, Sharon Chen, Catriona Halliday, Alex Kan, Jianghan Chen, Kurt R Wollenberg, Adrian Zelazny, John R Perfect, Yun C Chang, John E Bennett, Steven M Holland, Wieland Meyer, Peter R Williamson, Kyung J Kwon-Chung
The Cryptococcus gattii species complex has often been referred to as a primary pathogen due to its high infection frequency among apparently immunocompetent patients. In order to scrutinize the immune status of patients and the lineages of etiologic agents, we analyzed patient histories and the molecular types of etiologic agents from 135 global C. gattii cases. Eighty-six of 135 patients had been diagnosed as immunocompetent, although some of them had underlying medical issues, and 49 were diagnosed as immunocompromised with risk factors similar to those seen in Cryptococcus neoformans infection...
October 26, 2021: MBio
#36
JOURNAL ARTICLE
Quentin Moyon, Guillaume Lebreton, Florent Huang, Pierre Demondion, Cyrielle Desnos, Juliette Chommeloux, Guillaume Hékimian, Nicolas Bréchot, Ania Nieszkowska, Matthieu Schmidt, Pascal Leprince, Alain Combes, Charles-Edouard Luyt, Marc Pineton de Chambrun
OBJECTIVES: Postoperative mediastinitis, a feared complication after cardiac surgery, is associated with high mortality, especially of critically ill patients. Candida species infections are rare and severe, with poorly known outcomes. We conducted a case-control study to describe the characteristics, management and outcomes of patients with postoperative Candida mediastinitis. METHODS: This French, monocentre, retrospective study included all patients with postoperative Candida mediastinitis (January 2003-February 2020) requiring intensive care unit admission...
February 18, 2022: European Journal of Cardio-thoracic Surgery
#37
Manoela C Brandão, Fabio Benedetti, Séverine Martini, Yawouvi Dodji Soviadan, Jean-Olivier Irisson, Jean-Baptiste Romagnan, Amanda Elineau, Corinne Desnos, Laëtitia Jalabert, Andrea S Freire, Marc Picheral, Lionel Guidi, Gabriel Gorsky, Chris Bowler, Lee Karp-Boss, Nicolas Henry, Colomban de Vargas, Matthew B Sullivan, Lars Stemmann, Fabien Lombard
No abstract text is available yet for this article.
October 6, 2021: Scientific Reports
#38
JOURNAL ARTICLE
Caroline Mercier, Brice Roux, Marien Have, Léa Le Poder, Nathalie Duong, Pascale David, Nathalie Leonhardt, Laurence Blanchard, Christin Naumann, Steffen Abel, Laura Cuyas, Sylvain Pluchon, Nussaume Laurent, Thierry Desnos
STOP1, an Arabidopsis transcription factor favouring root growth tolerance against Al toxicity, acts in the response to iron under low Pi (-Pi). Previous studies have shown that Al and Fe regulate the stability and accumulation of STOP1 in roots, and that the STOP1 protein is sumoylated by an unknown E3 ligase. Here, using a forward genetics suppressor screen, we identified the E3 SUMO (small ubiquitin-like modifier) ligase SIZ1 as a modulator of STOP1 signalling. Mutations in SIZ1 increase the expression of ALMT1 (a direct target of STOP1) and root growth responses to Al and Fe stress in a STOP1-dependent manner...
October 6, 2021: Plant Journal
#39
JOURNAL ARTICLE
Erik Ganesh Iyer Søegaard, Zhanna Kan, Rishav Koirala, Edvard Hauff, Suraj Bahadur Thapa
Background: There are large gender differences in PTSD prevalence. Gender differences in a wide range of trauma symptoms including disturbances in self-organization have not been extensively researched. Objective: To explore gender differences in a wide range of trauma symptoms by comparing victimization trauma (VT) with accidental trauma (AT). Method: A cross-sectional study of 110 traumatized patients attending a mental health outpatient clinic in Oslo, Norway (38...
2021: European Journal of Psychotraumatology
#40
JOURNAL ARTICLE
Gregoire Desnos, Adrien Rubio, Chaimaa Gomri, Mathias Gravelle, Vincent Ladmiral, Mona Semsarilar
A set of well-defined amphiphilic, semi-fluorinated di and triblock copolymers were synthesized via polymerization-induced self-assembly (PISA) under alcoholic dispersion polymerization conditions. This study investigates the influence of the length, nature and position of the solvophobic semi-fluorinated block. A poly( N , N -dimethylaminoethyl methacrylate) was used as the stabilizing block to prepare the di and tri block copolymer nano-objects via reversible addition-fragmentation chain transfer (RAFT) controlled dispersion polymerization at 70 °C in ethanol...
July 29, 2021: Polymers
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