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https://www.readbyqxmd.com/read/27836513/anticoagulant-therapy-for-symptomatic-calf-deep-vein-thrombosis-cactus-a-randomised-double-blind-placebo-controlled-trial
#1
Marc Righini, Jean-Philippe Galanaud, Hervé Guenneguez, Dominique Brisot, Antoine Diard, Pascale Faisse, Marie-Thérèse Barrellier, Claudine Hamel-Desnos, Christine Jurus, Olivier Pichot, Myriam Martin, Lucia Mazzolai, Clarisse Choquenet, Sandrine Accassat, Helia Robert-Ebadi, Marc Carrier, Grégoire Le Gal, Bernadette Mermilllod, Jean-Pierre Laroche, Henri Bounameaux, Arnaud Perrier, Susan R Kahn, Isabelle Quere
BACKGROUND: The efficacy and safety of anticoagulant treatment is not established for patients with acute symptomatic deep vein thrombosis (DVT) of the calf. We aimed to assess whether therapeutic anticoagulation is superior to placebo in patients with symptomatic calf DVT. METHODS: In this randomised, double-blind, placebo-controlled trial, we enrolled low-risk outpatients (without active cancer or previous venous thromboembolic disease) with a first acute symptomatic DVT in the calf from 23 university medical centres or community medical clinics in Canada, France, and Switzerland...
November 7, 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27789540/environmental-distribution-of-cryptococcus-neoformans-and-c-gattii-around-the-mediterranean-basin
#2
Massimo Cogliati, Roberta D'Amicis, Alberto Zani, Maria Teresa Montagna, Giuseppina Caggiano, Osvalda De Giglio, Stella Balbino, Antonella De Donno, Francesca Serio, Serdar Susever, Cagri Ergin, Aristea Velegraki, Mohamed S Ellabib, Simona Nardoni, Cristina Macci, Salvatore Oliveri, Laura Trovato, Ludovico Dipineto, Volker Rickerts, Ilka McCormick-Smith, Sevim Akcaglar, Okan Tore, Emilija Mlinaric-Missoni, Sebastien Bertout, Michele Mallié, Maria da Luz Martins, Ana C F Vencà, Maria L Vieira, Ana C Sampaio, Cheila Pereira, Giuseppe Criseo, Orazio Romeo, Stéphane Ranque, Mohammed H Y Al-Yasiri, Meltem Kaya, Nilgun Cerikcioglu, Anna Marchese, Luigi Vezzulli, Macit Ilkit, Marie Desnos-Ollivier, Vincenzo Pasquale, Maya Korem, Itzhack Polacheck, Antonio Scopa, Wieland Meyer, Kennio Ferreira-Paim, Ferry Hagen, Bart Theelen, Teun Boekhout, Shawn R Lockhart, Kathrin Tintelnot, Anna Maria Tortorano, Françoise Dromer, Ashok Varma, Kyung J Kwon-Chung, Joäo Inácio, Beatriz Alonso, Maria F Colom
No abstract text is available yet for this article.
November 2016: FEMS Yeast Research
https://www.readbyqxmd.com/read/27685255/-development-and-validation-of-a-screening-instrument-for-complex-ptsd
#3
Florence Dorr, Christian Firus, Rolf Kramer, Jürgen Bengel
Chronic interpersonal traumata systematically result in psychological impairments referred to as complex post-traumatic stress disorder (cPTSD or DESNOS). This diagnosis will be newly established in the ICD-11 system. However, there is need for diagnostic instruments to assess cPTSD. The aim was to develop a screening form to identify patients at risk for cPTSD. The Screening for complex PTSD (SkPTBS) tests a) experience of potential traumatic events, b) related influential features and risk factors, and c) symptoms of cPTSD...
September 29, 2016: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/27413766/superresolving-dendritic-spine-morphology-with-sted-microscopy-under-holographic-photostimulation
#4
Marcel Andreas Lauterbach, Marc Guillon, Claire Desnos, Dany Khamsing, Zahra Jaffal, François Darchen, Valentina Emiliani
Emerging all-optical methods provide unique possibilities for noninvasive studies of physiological processes at the cellular and subcellular scale. On the one hand, superresolution microscopy enables observation of living samples with nanometer resolution. On the other hand, light can be used to stimulate cells due to the advent of optogenetics and photolyzable neurotransmitters. To exploit the full potential of optical stimulation, light must be delivered to specific cells or even parts of cells such as dendritic spines...
October 2016: Neurophotonics
https://www.readbyqxmd.com/read/27189955/high-prevalence-of-arrhythmic-and-myocardial-complications-in-patients-with-cardiac-glycogenosis-due-to-prkag2-mutations
#5
Julien Thevenon, Gabriel Laurent, Flavie Ader, Pascal Laforêt, Didier Klug, Anju Duva Pentiah, Laurent Gouya, Claude Alain Maurage, Salem Kacet, Jean-Christophe Eicher, Juliette Albuisson, Michel Desnos, Eric Bieth, Denis Duboc, Laurent Martin, Patricia Réant, François Picard, Claire Bonithon-Kopp, Elodie Gautier, Christine Binquet, Christel Thauvin-Robinet, Laurence Faivre, Patrice Bouvagnet, Philippe Charron, Pascale Richard
AIMS: Mutations in PRKAG2, the gene encoding for the γ2 subunit of 5'-AMP-activated protein kinase (AMPK), are responsible for an autosomal dominant glycogenosis with a cardiac presentation, associating hypertrophic cardiomyopathy (HCM), ventricular pre-excitation (VPE), and progressive heart block. The aim of this study was to perform a retrospective time-to-event study of the clinical manifestations associated with PRKAG2 mutations. METHODS AND RESULTS: A cohort of 34 patients from 9 families was recruited between 2001 and 2010...
May 17, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27188887/environmental-distribution-of-cryptococcus-neoformans-and-c-gattii-around-the-mediterranean-basin
#6
Massimo Cogliati, Roberta D'Amicis, Alberto Zani, Maria Teresa Montagna, Giuseppina Caggiano, Osvalda De Giglio, Stella Balbino, Antonella De Donno, Francesca Serio, Serdar Susever, Cagri Ergin, Aristea Velegraki, Mohamed S Ellabib, Simona Nardoni, Cristina Macci, Salvatore Oliveri, Laura Trovato, Ludovico Dipineto, Volker Rickerts, Ilka McCormick-Smith, Sevim Akcaglar, Okan Tore, Emilija Mlinaric-Missoni, Sebastien Bertout, Michele Mallié, Maria da Luz Martins, Ana C F Vencà, Maria L Vieira, Ana C Sampaio, Cheila Pereira, Giuseppe Griseo, Orazio Romeo, Stéphane Ranque, Mohammed H Y Al-Yasiri, Meltem Kaya, Nilgun Cerikcioglu, Anna Marchese, Luigi Vezzulli, Macit Ilkit, Marie Desnos-Ollivier, Vincenzo Pasquale, Maya Korem, Itzhack Polacheck, Antonio Scopa, Wieland Meyer, Kennio Ferreira-Paim, Ferry Hagen, Bart Theelen, Teun Boekhout, Shawn R Lockhart, Kathrin Tintelnot, Anna Maria Tortorano, Françoise Dromer, Ashok Varma, Kyung J Kwon-Chung, Joäo Inácio, Beatriz Alonso, Maria F Colom
In order to elucidate the distribution of Cryptococcus neoformans and C. gattii in the Mediterranean basin, an extensive environmental survey was carried out during 2012-2015. A total of 302 sites located in 12 countries were sampled, 6436 samples from 3765 trees were collected and 5% of trees were found to be colonized by cryptococcal yeasts. Cryptococcus neoformans was isolated from 177 trees and C. gattii from 13. Cryptococcus neoformans colonized 27% of Ceratonia, 10% of Olea, Platanus and Prunus trees and a lower percentage of other tree genera...
June 2016: FEMS Yeast Research
https://www.readbyqxmd.com/read/27076666/novel-taxa-associated-with-human-fungal-black-grain-mycetomas-emarellia-grisea-gen-nov-sp-nov-and-emarellia-paragrisea-sp-nov
#7
Andrew M Borman, Marie Desnos-Ollivier, Colin K Campbell, Paul D Bridge, Eric Dannaoui, Elizabeth M Johnson
Eumycetoma is a debilitating, chronic, fungal infection that is endemic in India, Indonesia, and parts of Africa and South and Central America. It remains a neglected tropical disease in need of international recognition. Infections follow traumatic implantation of saprophytic fungi and frequently require radical surgery or amputation in the absence of appropriate treatment. Several fungal species can cause black-grain mycetomas, including Madurella spp. (Sordariales), Falciformispora spp., Trematosphaeria grisea, Biatriospora mackinnonii, Pseudochaetosphaeronema larense, and Medicopsis romeroi (all Pleosporales)...
July 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27068734/sclerotherapy-is-a-safe-method-of-treatment-of-chronic-venous-disorders-in-older-patients-a-prospective-and-comparative-study-of-consecutive-patients
#8
Jean-Luc Gillet, Claudine H Desnos, Michel Lausecker, Christian Daniel, Jean-Jerome Guex, François-André Allaert
OBJECTIVES: An aging population requires evaluation of methods of treatment for older patients. Our objective was to evaluate the indications, practical modalities, safety and tolerability of sclerotherapy in patients 75 years of age and older (group 1) and compare with a control group of patients 18 to74 years of age (group 2). METHOD: This observational, multicentre, prospective and comparative study was conducted by the French Society of Phlebology. Each centre collected in 10 to 20 patients ≥75 years of age and an equal number of patients <75 years of age treated by sclerotherapy, the treatment indication, the patient's personal history, the CEAP clinical class, the type of the veins being treated, the characteristics of sclerotherapy and the complications (immediately after treatment and at one-month follow-up)...
April 11, 2016: Phlebology
https://www.readbyqxmd.com/read/26342461/substrate-specificity-of-plant-and-fungi-pectin-methylesterases-identification-of-novel-inhibitors-of-pmes
#9
Mélanie L'Enfant, Jean-Marc Domon, Catherine Rayon, Thierry Desnos, Marie-Christine Ralet, Estelle Bonnin, Jérôme Pelloux, Corinne Pau-Roblot
Pectin methylesterases (PMEs) play a central role in pectin remodeling during plant development. They are also present in phytopathogens such as bacteria and fungi. We investigated the substrate specificity and pH dependence of plant and fungi PMEs using tailor-made pectic substrates. For this purpose, we used two plant PMEs (from orange peel: Citrus sinensis and from Arabidopsis thaliana) and one fungal PME (from Botrytis cinerea). We showed that plant and fungi PMEs differed in their substrate specificity and pH dependence, and that there were some differences between plant PMEs...
November 2015: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/26299232/survival-from-sports-related-sudden-cardiac-arrest-in-sports-facilities-versus-outside-of-sports-facilities
#10
MULTICENTER STUDY
Eloi Marijon, Wulfran Bougouin, Nicole Karam, Frankie Beganton, Lionel Lamhaut, Marie-Cécile Perier, Nordine Benameur, Muriel Tafflet, Guillaume Beal, Albert Hagege, Jean-Yves Le Heuzey, Michel Desnos, Christian Spaulding, Francois Carré, Florence Dumas, David S Celermajer, Alain Cariou, Xavier Jouven
BACKGROUND: We sought to evaluate frequency, characteristics, and outcomes of sudden cardiac arrest (SCA) during sports activities according to the location of occurrence (in sports facilities vs those occurring outside of sports facilities). METHODS AND RESULTS: This is an observational 5-year prospective national French survey of subjects 10 to 75 years old presenting with SCA during sports (2005-2010), in 60 French administrative regions (covering a population of 35 million people)...
August 2015: American Heart Journal
https://www.readbyqxmd.com/read/26246484/application-of-isothermal-amplification-techniques-for-identification-of-madurella-mycetomatis-the-prevalent-agent-of-human-mycetoma
#11
COMPARATIVE STUDY
Sarah A Ahmed, Wendy W J van de Sande, Marie Desnos-Ollivier, Ahmed H Fahal, Najwa A Mhmoud, G S de Hoog
Appropriate diagnosis and treatment of eumycetoma may vary significantly depending on the causative agent. To date, the most common fungus causing mycetoma worldwide is Madurella mycetomatis. This species fails to express any recognizable morphological characteristics, and reliable identification can therefore only be achieved with the application of molecular techniques. Recombinase polymerase amplification (RPA) and loop-mediated isothermal amplification (LAMP) are proposed as alternatives to phenotypic methods...
October 2015: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/26243630/a-chemical-genetic-strategy-identify-the-phostin-a-synthetic-molecule-that-triggers-phosphate-starvation-responses-in-arabidopsis-thaliana
#12
Clémence Bonnot, Benoît Pinson, Mathilde Clément, Stéphane Bernillon, Serge Chiarenza, Satomi Kanno, Natsuko Kobayashi, Etienne Delannoy, Tomoko M Nakanishi, Laurent Nussaume, Thierry Desnos
Plants display numerous strategies to cope with phosphate (Pi)-deficiency. Despite multiple genetic studies, the molecular mechanisms of low-Pi-signalling remain unknown. To validate the interest of chemical genetics to investigate this pathway we discovered and analysed the effects of PHOSTIN (PSN), a drug mimicking Pi-starvation in Arabidopsis. We assessed the effects of PSN and structural analogues on the induction of Pi-deficiency responses in mutants and wild-type and followed their accumulation in plants organs by high pressure liquid chromotography (HPLC) or mass-spectrophotometry...
January 2016: New Phytologist
https://www.readbyqxmd.com/read/26231456/first-clinical-use-of-a-bioprosthetic-total-artificial-heart-report-of-two-cases
#13
MULTICENTER STUDY
Alain Carpentier, Christian Latrémouille, Bernard Cholley, David M Smadja, Jean-Christian Roussel, Elodie Boissier, Jean-Noël Trochu, Jean-Pierre Gueffet, Michèle Treillot, Philippe Bizouarn, Denis Méléard, Marie-Fazia Boughenou, Olivier Ponzio, Marc Grimmé, Antoine Capel, Piet Jansen, Albert Hagège, Michel Desnos, Jean-Noël Fabiani, Daniel Duveau
BACKGROUND: The development of artificial hearts in patients with end-stage heart disease have been confronted with the major issues of thromboembolism or haemorrhage. Since valvular bioprostheses are associated with a low incidence of these complications, we decided to use bioprosthetic materials in the construction of a novel artificial heart (C-TAH). We report here the device characteristics and its first clinical applications in two patients with end-stage dilated cardiomyopathy. The aim of the study was to evaluate safety and feasibility of the CARMAT TAH for patients at imminent risk of death from biventricular heart failure and not eligible for transplant...
October 17, 2015: Lancet
https://www.readbyqxmd.com/read/26060271/cryptococcosis-serotypes-impact-outcome-and-provide-evidence-of-cryptococcus-neoformans-speciation
#14
Marie Desnos-Ollivier, Sweta Patel, Dorothée Raoux-Barbot, Joseph Heitman, Françoise Dromer
UNLABELLED: Cryptococcus neoformans is a human opportunistic fungal pathogen causing severe disseminated meningoencephalitis, mostly in patients with cellular immune defects. This species is divided into three serotypes: A, D, and the AD hybrid. Our objectives were to compare population structures of serotype A and D clinical isolates and to assess whether infections with AD hybrids differ from infections with the other serotypes. For this purpose, we analyzed 483 isolates and the corresponding clinical data from 234 patients enrolled during the CryptoA/D study or the nationwide survey on cryptococcosis in France...
2015: MBio
https://www.readbyqxmd.com/read/25990469/human-embryonic-stem-cell-derived-cardiac-progenitors-for-severe-heart-failure-treatment-first-clinical-case-report
#15
Philippe Menasché, Valérie Vanneaux, Albert Hagège, Alain Bel, Bernard Cholley, Isabelle Cacciapuoti, Alexandre Parouchev, Nadine Benhamouda, Gérard Tachdjian, Lucie Tosca, Jean-Hugues Trouvin, Jean-Roch Fabreguettes, Valérie Bellamy, Romain Guillemain, Caroline Suberbielle Boissel, Eric Tartour, Michel Desnos, Jérôme Larghero
AIMS: Comparative studies suggest that stem cells committed to a cardiac lineage are more effective for improving heart function than those featuring an extra-cardiac phenotype. We have therefore developed a population of human embryonic stem cell (ESC)-derived cardiac progenitor cells. METHODS AND RESULTS: Undifferentiated human ESCs (I6 line) were amplified and cardiac-committed by exposure to bone morphogenetic protein-2 and a fibroblast growth factor receptor inhibitor...
August 7, 2015: European Heart Journal
https://www.readbyqxmd.com/read/25971145/-difficulties-in-the-assessment-of-trauma-related-disorders
#16
W Gronau, A Meyer-Lindenberg, H Dreßing
Assessment of trauma disorders is becoming increasingly important. A major problem here is that trauma disorders are extremely heterogeneous. Moreover, they are often associated with comorbid disorders, such as borderline personality disorder. The valid diagnostic systems ICD-10 and DSM-5 poorly represent trauma disorders. The so-called complex post-traumatic stress disorder or DESNOS (disorders of extreme stress not otherwise specified) are listed .in either of the ICD-10 or DSM-5. The distinctiveness is not generally scientifically accepted...
March 1, 2015: Versicherungsmedizin
https://www.readbyqxmd.com/read/25815196/chronic-pain-in-multi-traumatized-outpatients-with-a-refugee-background-resettled-in-norway-a-cross-sectional-study
#17
Dinu-Stefan Teodorescu, Trond Heir, Johan Siqveland, Edvard Hauff, Tore Wentzel-Larsen, Lars Lien
BACKGROUND: Traumatized refugees often report significant levels of chronic pain in addition to posttraumatic stress disorder symptoms, and more information is needed to understand pain in refugees exposed to traumatic events. This study aimed to assess the frequency of chronic pain among refugee psychiatric outpatients, and to compare outpatients with and without chronic pain on trauma exposure, psychiatric morbidity, and psychiatric symptom severity. METHODS: We conducted a cross-sectional study of sixty-one psychiatric outpatients with a refugee background using structured clinical diagnostic interviews to assess for traumatic events [Life Events Checklist (LEC)], PTSD (Posttraumatic Stress Disorder) and complex PTSD [Structured Clinical Interview for DSM-IV PTSD Module (SCID-PTSD) and Structured Interview for Disorders of Extreme Stress (SIDES)], chronic pain (SIDES Scale VI) and psychiatric symptoms [M...
2015: BMC Psychology
https://www.readbyqxmd.com/read/25802363/international-society-of-human-and-animal-mycology-isham-its-reference-dna-barcoding-database-the-quality-controlled-standard-tool-for-routine-identification-of-human-and-animal-pathogenic-fungi
#18
Laszlo Irinyi, Carolina Serena, Dea Garcia-Hermoso, Michael Arabatzis, Marie Desnos-Ollivier, Duong Vu, Gianluigi Cardinali, Ian Arthur, Anne-Cécile Normand, Alejandra Giraldo, Keith Cassia da Cunha, Marcelo Sandoval-Denis, Marijke Hendrickx, Angela Satie Nishikaku, Analy Salles de Azevedo Melo, Karina Bellinghausen Merseguel, Aziza Khan, Juliana Alves Parente Rocha, Paula Sampaio, Marcelo Ribeiro da Silva Briones, Renata Carmona e Ferreira, Mauro de Medeiros Muniz, Laura Rosio Castañón-Olivares, Daniel Estrada-Barcenas, Carole Cassagne, Charles Mary, Shu Yao Duan, Fanrong Kong, Annie Ying Sun, Xianyu Zeng, Zuotao Zhao, Nausicaa Gantois, Françoise Botterel, Barbara Robbertse, Conrad Schoch, Walter Gams, David Ellis, Catriona Halliday, Sharon Chen, Tania C Sorrell, Renaud Piarroux, Arnaldo L Colombo, Célia Pais, Sybren de Hoog, Rosely Maria Zancopé-Oliveira, Maria Lucia Taylor, Conchita Toriello, Célia Maria de Almeida Soares, Laurence Delhaes, Dirk Stubbe, Françoise Dromer, Stéphane Ranque, Josep Guarro, Jose F Cano-Lira, Vincent Robert, Aristea Velegraki, Wieland Meyer
Human and animal fungal pathogens are a growing threat worldwide leading to emerging infections and creating new risks for established ones. There is a growing need for a rapid and accurate identification of pathogens to enable early diagnosis and targeted antifungal therapy. Morphological and biochemical identification methods are time-consuming and require trained experts. Alternatively, molecular methods, such as DNA barcoding, a powerful and easy tool for rapid monophasic identification, offer a practical approach for species identification and less demanding in terms of taxonomical expertise...
May 2015: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/25762061/population-movement-and-sudden-cardiac-arrest-location
#19
Eloi Marijon, Wulfran Bougouin, Muriel Tafflet, Nicole Karam, Daniel Jost, Lionel Lamhaut, Frankie Beganton, Patricia Pelloux, Hervé Degrange, Guillaume Béal, Jean-Pierre Tourtier, Albert A Hagège, Jean-Yves Le Heuzey, Michel Desnos, Florence Dumas, Christian Spaulding, David S Celermajer, Alain Cariou, Xavier Jouven
BACKGROUND: Although the benefits of automatic external defibrillators are undeniable, their effectiveness could be dramatically improved. One of the key issues is the disparity between the locations of automatic external defibrillators and sudden cardiac arrests (SCAs). METHODS AND RESULTS: From emergency medical services and other Parisian agencies, data on all SCAs occurring in public places in Paris, France, were prospectively collected between 2000 and 2010 and recorded using 2020 grid areas...
May 5, 2015: Circulation
https://www.readbyqxmd.com/read/25754909/rupture-of-mitral-valve-chordae-in-hypertrophic-cardiomyopathy
#20
Florence Boissier, Guy Achkouty, Patrick Bruneval, Jean-Noël Fabiani, Anh Tuan Nguyen, Elisabeth Riant, Michel Desnos, Albert Hagège
BACKGROUND: While occasional reports of mitral valve chordal rupture have been described in hypertrophic cardiomyopathy, the exact prevalence and characteristics of this event in a large medical cohort have not been reported. AIM: To assess the prevalence of mitral valve chordal rupture in hypertrophic cardiomyopathy and the clinical, echocardiographic, surgical and histological profiles of those patients. METHODS: We searched for patients with mitral valve chordal rupture diagnosed by echocardiography among all electronic files of patients admitted to our centre for hypertrophic cardiomyopathy between 2000 and 2010...
April 2015: Archives of Cardiovascular Diseases
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