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Docetaxol lung effects

Xiang Yan, Xiao Zhao, Shunchang Jiao, Shengjie Sun, Liangliang Wu, Zhiyong Wu
BACKGROUND AND OBJECTIVE: The immune function disorder relates closely to the occurrence, metastasis, and prognosis of cancer. T lymphocyte subsets take an important role in immune function. We identified the dynamic changes of the immune system by investigating the levels of T lymphocyte subsets in peripheral blood of lung cancer patients with advanced stage adenocarcinoma undergoing first line chemotherapy. The results aided the search for rational chemo-immunotherapy strategies in lung cancer treatment...
March 2012: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Ji-qing Hao, Qi Li, Shu-ping Xu, Yu-xian Shen, Gen-yun Sun
BACKGROUND: Lumiracoxib is a highly selective cyclooxygenase-2 (COX-2) inhibitor with antiinflammatory, analgesic and antipyretic activities comparable with class specific drugs, but with much improved gastrointestinal safety. No studies have examined lumiracoxib for antitumorigenic activity on human nonsmall cell lung cancer cell lines in vitro or its possible molecular mechanisms. METHODS: The antiproliferative effect of lumiracoxib alone or combined with docetaxol on A549 and NCI-H460 lines was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay...
April 5, 2008: Chinese Medical Journal
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