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https://www.readbyqxmd.com/read/28732415/in-reply-to-risk-factors-for-poor-outcome-in-hypertensive-intraventricular-hemorrhage-treated-by-external-ventricular-drainage-with-intraventricular-fibrinolysis-statistical-and-methodologic-issues
#1
https://www.readbyqxmd.com/read/28732414/risk-factors-for-poor-outcome-in-hypertensive-intraventricular-hemorrhage-treated-by-external-ventricular-drainage-with-intraventricular-fibrinolysis-statistical-and-methodologic-issues
#2
https://www.readbyqxmd.com/read/28732397/combined-sewer-overflow-events-and-childhood-emergency-department-visits-a-case-crossover-study
#3
Cole Brokamp, Andrew F Beck, Louis Muglia, Patrick Ryan
In localities with combined sewer systems, combined sewer overflow (CSO) events frequently occur following high precipitation and can result in the release of untreated sewage and industrial wastewater into surface waters. We hypothesized that either direct contact with or proximity to aerosolized CSO effluent would increase the risk for childhood emergency department (ED) visits for asthma, gastrointestinal (GI) illnesses, and skin and soft tissue infections (SSTIs) in Cincinnati, OH, USA. ED visits for 2010-2014 due to GI diseases, asthma, and SSTIs were extracted from the Cincinnati Children's Hospital Medical Center electronic health records...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732371/the-impacts-of-surgery-of-the-primary-cancer-and-radiotherapy-on-the-survival-of-patients-with-metastatic-rectal-cancer
#4
Duo Tong, Fei Liu, Wenhua Li, Wen Zhang
The role of surgery of the primary cancer and radiation in metastatic colorectal cancer (mCRC) is still controversial currently, and evidence implied that colon cancer (CC) and rectal cancer (RC) should be treated with difference. Hence we focused on metastatic rectal cancer (mRC) solely to compare the cancer cause-specific survival (CSS) of patients receiving varied treatments of the primary cancer: no treatment, surgery only, radiation only, and surgery plus radiation, based on the records of the Surveillance, Epidemiology, and End Results (SEER) database...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732368/meta-analysis-of-micrornas-expression-in-head-and-neck-cancer-uncovering-association-with-outcome-and-mechanisms
#5
Joshua Lubov, Mariana Maschietto, Iman Ibrahim, Alex Mlynarek, Michael Hier, Luiz Paulo Kowalski, Moulay A Alaoui-Jamali, Sabrina Daniela da Silva
Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at advanced stages, incurring significant high mortality and morbidity. This review explored the risk stratification of miRNAs, and investigated the impact of miRNA networking in HNSCC prognostication. We performed a meta-analysis and a systematic literature search on online databases for papers published prior to December 1, 2016. The list of miRNAs was uploaded to MetacoreTM to construct a protein-protein interaction network, which was used to identify targets of the miRNAs and potential drugs...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732353/serum-insulin-like-growth-factor-1-and-its-binding-protein-3-as-prognostic-factors-for-the-incidence-progression-and-outcome-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#6
Jing Wang, Yu-Chuan Li, Min Deng, Hai-Yin Jiang, Li-Hua Guo, Wen-Juan Zhou, Bing Ruan
PURPOSE: Previous studies have supported an association between serum insulin-like growth factor 1 (IGF1) and IGF-binding protein 3 (IGFBP3) levels and hepatocellular carcinoma (HCC), but the results were inaccurate. It has recently been proposed that IGF1 and IGFBP3 play roles in the time-to-progression (TTP) and overall survival (OS) of HCC patients. Our results revealed that serum IGF1 level is predictive of the progression and survival of HCC patients. RESULTS: HCC was associated with a significant reduction in serum IGF-1 and IGFBP-3 levels compared to cirrhosis (p = 0...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732352/cerebral-blood-flow-changes-in-remitted-early-and-late-onset-depression-patients
#7
Wenxiang Liao, Ze Wang, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, Zhijun Zhang
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732349/intracoronary-administration-of-tirofiban-during-percutaneous-coronary-intervention-facilitates-patients-with-acute-coronary-syndrome
#8
Helei Jia, Changqing Lu, Panli Sun
We assessed the efficacy and safety of tirofiban intracoronary versus intravenous administration during percutaneous coronary intervention for patients with acute coronary syndrome. The databases of PubMed, Web of Science, China National Knowledge Infrastructure, and WanFang Database were retrieved. A total of 437 articles were found, according to inclusive and exclusive criteria, 13 of which were finally included. Compared with subjects with intravenous administration, those with intracoronary administration were more likely to reach thrombolysis in myocardial infarction trial grade 3 flow (relative risk = 1...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732322/effects-of-environmental-pollutants-on-signaling-pathways-in-rat-pituitary-gh3-adenoma-cells
#9
Nicoletta Fortunati, Federica Guaraldi, Valentina Zunino, Federica Penner, Valentina D'Angelo, Francesco Zenga, Francesca Pecori Giraldi, Maria Graziella Catalano, Emanuela Arvat
An increased rate of acromegaly was reported in industrialized areas, suggesting an involvement of environmental pollutants in the pathogenesis and behavior of GH-secreting pituitary adenomas. Based on these premises, the aim of the study was to evaluate the effects of some widely diffused pollutants (i.e. benzene, BZ; bis(2-ethylhexyl) phthalate, DEHP and polychlorinated biphenyls, PCB) on growth hormone secretion, the somatostatin and estrogenic pathways, viability and proliferation of rat GH-producing pituitary adenoma (GH3) cells...
July 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28732319/did-the-dependent-coverage-expansion-increase-risky-substance-use-among-young-adults
#10
Joshua Breslau, Hao Yu, Bing Han, Rosalie L Pacula, Rachel M Burns, Bradley D Stein
BACKGROUND: The dependent coverage expansion (DCE) enacted through the Affordable Care Act increased health insurance coverage among young adults. Increasing insurance coverage in this age group has the potential for unintended consequences on risky substance use. METHODS: Repeated cross-sectional surveys were used to compare change in substance use during the period the DCE was implemented in the 19-25year old target age group (Pre-DCE n=15,772, Post-DCE n=22,719) with contemporaneous change in a slightly older age group that was not targeted by the policy (Pre-DCE=19,851, Post-DCE n=28,157)...
July 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28732315/total-and-ionized-magnesium-testing-in-the-surgical-intensive-care-unit-opportunities-for-improved-laboratory-and-pharmacy-utilization
#11
Daniel Dante Yeh, Nalin Chokengarmwong, Yuchiao Chang, Liyang Yu, Colleen Arsenault, Joseph Rudolf, Elizabeth Lee-Lewandrowski, Kent Lewandrowski
PURPOSE: Ionized fraction (iMg) is the physiologically active form of magnesium (Mg); total Mg may not accurately reflect iMg status. Erroneously "low" Mg levels may result in unnecessary repetitive testing. MATERIALS AND METHODS: From 11/2015 to 01/2016, patients ordered for Mg from a pilot ICU also had iMg tested. Weighted kappa statistic was used to assess agreement between Mg categories (low, normal, high). Predictors of unnecessary repeated Mg testing and repletion using data were explored through logistic regression models using GEE techniques to account for repeated measurements in both bivariate and multivariable analyses...
July 11, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28732307/a-multisite-audit-to-assess-how-women-with-complex-social-factors-access-and-engage-with-maternity-services
#12
Hannah Rayment-Jones, Eleanor Butler, Chelsie Miller, Christine Nay, Jennifer O'Dowd
OBJECTIVE: to audit women with socially complex lives' documented access to and engagement with antenatal care provided by three inner city, UK maternity services in relation to birth and neonatal outcomes, and referral processes. BACKGROUND: women living socially complex lives, including young mothers, recently arrived immigrants, non-English speaking, and those experiencing domestic violence, poor mental health, drug and alcohol abuse, and poverty experience high rates of morbidity, mortality and poor birth outcomes...
June 27, 2017: Midwifery
https://www.readbyqxmd.com/read/28732273/using-computational-theory-to-constrain-statistical-models-of-neural-data
#13
REVIEW
Scott W Linderman, Samuel J Gershman
Computational neuroscience is, to first order, dominated by two approaches: the 'bottom-up' approach, which searches for statistical patterns in large-scale neural recordings, and the 'top-down' approach, which begins with a theory of computation and considers plausible neural implementations. While this division is not clear-cut, we argue that these approaches should be much more intimately linked. From a Bayesian perspective, computational theories provide constrained prior distributions on neural data-albeit highly sophisticated ones...
July 18, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28732261/predictors-of-disclosure-management-behavior-at-the-end-of-1-year-follow-up-in-korean-adults-with-newly-diagnosed-epilepsy
#14
Sang-Ahm Lee, Soon-Kee No, Hyungkook Park, Ok-Joon Kim, Jee-Hyun Kwon, Ji-Yeon Ryu, Sang-Moo Lee, Kwang-Deog Jo
PURPOSE: Epilepsy is a concealable stigmatizing condition. We investigated the factors predicting disclosure management behavior in Korean adults with newly diagnosed epilepsy. METHODS: This longitudinal multicenter study included Korean adults with newly diagnosed epilepsy. Using statistical analyses, we determined at the end of a 1-year follow-up whether Disclosure Management Scale (DMS) scores were predicted by demographic, clinical, and psychosocial variables, including felt stigma, stress coping style, personality traits, social support, and experienced discrimination from society...
July 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28732242/the-depression-and-marital-status-relationship-is-modified-by-both-age-and-gender
#15
Andrew G M Bulloch, Jeanne V A Williams, Dina H Lavorato, Scott B Patten
BACKGROUND: Marital status is associated with major depression prevalence, however, the strength of association may be modified by age and gender. METHODS: The data sources were a series of cross sectional national health surveys of the Canadian population carried out by Statistics Canada during 1996-2013. These were cross-sectional files from the National Population Health Survey of 1996, together with the Canadian Community Health Surveys from 2000 to 2013; the respondents were 18 years and older...
July 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28732224/three-dimensional-changes-in-the-upper-airway-of-skeletal-class-iii-patients-after-different-orthognathic-surgical-procedures
#16
Yuxue Yang, Kai Yang, Ying Zhao
PURPOSE: We hypothesized that 3-dimensional changes in the upper airway of patients with skeletal Class III malocclusion are different after mandibular setback and maxillary advancement (MSMA) compared with mandibular setback (MS) and that upper airway changes and the amount of jaw movement are correlated. PATIENTS AND METHODS: Skeletal Class III patients who underwent MS surgery or MSMA surgery were included in this retrospective cohort study. Cone beam computed tomography scans were acquired before and 3 months after surgery...
June 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28732209/the-effect-of-a-peer-education-program-on-combating-violence-against-women-a-randomized-controlled-study
#17
Özlem C Gürkan, Nuran Kömürcü
BACKGROUND: Student nurses in Turkey need to be exposed to appropriate undergraduate training if they are to acquire the required knowledge, attitudes and skills that will help them to fight the issue of violence against women (VAW). OBJECTIVES: The aim of this research study was to assess the effect of a peer education program about combating VAW on the knowledge, attitudes and skills of nursing students. DESIGN: The study was designed as a randomized controlled trial...
July 12, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28732157/large-scale-statistics-for-threshold-optimization-of-optically-pumped-nanowire-lasers
#18
Juan Arturo Alanis, Dhruv Saxena, Sudha Mokkapati, Nian Jiang, Kun Peng, Xiaoyan Tang, Lan Fu, Hark Hoe Tan, Chennupati Jagadish, Patrick Parkinson
Single nanowire lasers based on bottom-up III-V materials have been shown to exhibit room-temperature near-infrared lasing, making them highly promising for use as nanoscale, silicon-integrable and coherent light sources. While lasing behavior is reproducible, small variations in growth conditions across a substrate arising from the use of bottom-up growth techniques can introduce inter-wire disorder, either through geometric or material inhomogeneity. Nanolasers critically depend on both high material quality and tight dimensional tolerances, and as such, lasing threshold is both sensitive to, and a sensitive probe of such inhomogeneity...
July 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28732149/beware-of-the-origin-of-numbers-standard-scoring-of-the-sf-12-and-sf-36-summary-measures-distorts-measurement-and-score-interpretations
#19
Peter Hagell, Albert Westergren, Kristofer Årestedt
The 12-item Short Form Health Survey (SF-12) is a generic health rating scale developed to reproduce the Physical and Mental Component Summary scores (PCS and MCS, respectively) of a longer survey, the SF-36. The standard PCS/MCS scoring algorithm has been criticized because its expected dimensionality often lacks empirical support, scoring is based on the assumption that physical and mental health are uncorrelated, and because scores on physical health items influence MCS scores, and vice versa. In this paper, we review the standard PCS/MCS scoring algorithm for the SF-12 and consider alternative scoring procedures: the RAND-12 Health Status Inventory (HSI) and raw sum scores...
August 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/28732141/intraoperative-ultrasound-for-prediction-of-hepatocellular-carcinoma-biological-behavior-prospective-comparison-with-pathology
#20
Roberto Santambrogio, Claudia Cigala, Matteo Barabino, Marco Maggioni, Giovanna Scifo, Savino Bruno, Emanuela Bertolini, Enrico Opocher, Gaetano Bulfamante
BACKGROUND AND AIMS: Preoperative prediction of both microinvasive hepatocellular carcinoma and histological grade of hepatocellular carcinoma is pivotal to treatment planning and prognostication. Aim of the study was to evaluate whether some intraoperative ultrasound features correlate with both the presence of same histological patterns and differentiation grade of hepatocellular carcinoma on the histologic features of the primary resected tumor. METHODS: All patients with single, small hepatocellular carcinoma that underwent hepatic resection were included in this prospective double-blind study: the intraoperative ultrasound patterns of nodule were registered and compared with similar histological features...
July 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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