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Korgün Ökmen, Burcu Metin Ökmen, Serra Topal
STUDY OBJECTIVE: Laparoscopic techniques are commonly used in surgical operations of the gallbladder. There are very few regional anesthesia methods used to achieve this goal. We aimed to investigate the effect of ultrasound-guided posterior quadratus lumborum block (QLB), administered bilaterally on pain scores after laparoscopic cholecystectomy operations. DESIGN: Prospective, double blind, randomized controlled clinical trial. SETTING: Single-institution, tertiary hospital...
June 18, 2018: Journal of Clinical Anesthesia
Jason L Miller, Jim Sherry, Joanne Parrott, James S Quinn
Polycyclic aromatic hydrocarbons (PAHs) have become ubiquitous in the aquatic environment. Some PAHs are mutagenic, potentially causing germline mutations in fish that inhabit PAH contaminated waters. We evaluated the effect of exposure to sediment-borne PAHs on reproduction and germline mutation rates in fathead minnows (Pimephales promelas). Exposure to the contaminated sediment had no significant impact on the reproductive endpoints measured in this study. Germline mutations rates at three microsatellite DNA loci were 1...
June 18, 2018: Ecotoxicology and Environmental Safety
Meng-Na Zhang, Li-Ping Zou, Yang-Yang Wang, Ling-Yu Pang, Shu-Fang Ma, Lu-Lu Huang, Yang Gao, Qian Lu, David Neal Franz
PURPOSE: Tuberous sclerosis (TSC) is an autosomal dominant inherited disease caused by mutations in the TSC1 or TSC2 gene and results in the over-activation of the mammalian target of the rapamycin (mTOR) signaling pathway. Rapamycin, an mTOR inhibitor, is clinically used to treat hamartomatous lesionsas in TSC and its effect on controlling epilepsy is also reported in many studies. This study aims to evaluate the risk factors of pharmacoresistant epilepsy in patients with TSC receiving long-term rapamycin treatment...
June 15, 2018: Seizure: the Journal of the British Epilepsy Association
Kate Hoffman, Stephanie C Hammel, Allison L Phillips, Amelia M Lorenzo, Albert Chen, Antonia M Calafat, Xiaoyun Ye, Thomas F Webster, Heather M Stapleton
Semi-volatile organic compounds (SVOCs) are used extensively in consumer and personal care products; electronics; furniture; and building materials and are detected in most indoor environments. As a result, human exposure to mixtures of SVOCs is wide-spread. However, very few studies have measured biomarkers of exposure to multiple SVOC classes, and exposure determinants have not been thoroughly explored, particularly for young children. In this study, we investigated biomarkers of exposure to SVOCs among children (age 3-6 years), who may experience higher exposures and be more susceptible to adverse health outcomes than other age groups...
June 18, 2018: Environment International
Bénédicte Buffin-Meyer, Julie Klein, Benjamin Breuil, Françoise Muller, Panagiotis Moulos, Marion Groussolles, Ourdia Bouali, Jean-Loup Bascands, Stéphane Decramer, Joost P Schanstra
Most of biomarker panels, extracted from single omics traits, still need improvement since they display a gray zone where prediction is uncertain. Here we verified whether a combination of omics traits, fetal urinary metabolites and peptides analyzed in the same sample, improved prediction of postnatal renal function in fetuses with posterior urethral valves (PUV) compared to individual omics traits. Using CE-MS, we explored the urinary metabolome of 13 PUV fetuses with end stage renal disease (ESRD) and 12 PUV fetuses without postnatal ESRD at 2 years postnatally...
June 18, 2018: Journal of Proteomics
Chang Hun Kim, Jong Soo Kang, Wi-Sun Ryu, Chul-Ho Sohn, Byung-Woo Yoon
BACKGROUND: Carotid Doppler sonography (CDS) has been routinely used in the screening for restenosis after carotid artery stenting (CAS) by applying the criteria of flow velocity, however, computed tomography angiography (CTA) enables us to detect restenosis directly and has some advantages that help to overcome the limitations of CDS. We aimed to investigate the incidence of restenosis with CTA and to identify factors related to restenosis after CAS. METHODS: We conducted a retrospective study of 225 patients (235 arteries, mean age of 71...
June 18, 2018: World Neurosurgery
Bowen Hu, Xi Yang, Huiliang Yang, Limin Liu, Peiran Chen, Linnan Wang, Ce Zhu, Chunguang Zhou, Yueming Song
BACKGROUND: Choosing the fusion level for posterior fusion in Lenke 5C adolescent idiopathic scoliosis patients is highly associated with coronal balance. Previous studies indicated that in patients with lowest end vertebra tilt > 25°, surgeons could extend distal fusion to avoid coronal imbalance. This study aimed to assess the risk factors for coronal imbalance in Lenke 5C scoliosis, and to discuss how to select fusion level. METHODS: We reviewed 59 Lenke 5C AIS patients in one institution with at least 2-years' follow-up from 2010 through 2015...
June 18, 2018: World Neurosurgery
István Márkus, Ádám Tibor Schlégl, Máté Burkus, Kristóf József, Bálint Niklai, Péter Than, Miklós Tunyogi-Csapó
STUDY HYPOTHESIS: We hypothesized that altered coronal balance in adolescent scoliosis leads to asymmetric stress on the lower limbs, with subsequent effects on bone maturation and later morphology. We aimed to assess the correlation between the biomechanical parameters of the lower limbs and coronal balance in idiopathic scoliosis. MATERIALS AND METHODS: In this study, EOS images of 280 patients and 56 controls were randomly selected from our clinics' database...
June 18, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Erin M Harvey, Eileen R McGrath, Joseph M Miller, Amy L Davis, J Daniel Twelker, Leslie K Dennis
PURPOSE: To determine whether uncorrected astigmatism in toddlers is associated with poorer performance on the Bayley Scales of Infant and Toddler Development, 3rd edition (BSITD-III). METHODS: Subjects were 12- to 35-month-olds who failed an instrument-based vision screening at a well-child check. A cycloplegic eye examination was conducted. Full-term children with no known medical or developmental conditions were invited to participate in a BSITD-III assessment conducted by an examiner masked to the child's eye examination results...
June 18, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Christopher Strouse, Ying Zhang, Mei-Jie Zhang, Alyssa DiGilio, Marcelo Pasquini, Mary M Horowitz, Stephanie Lee, Vincent Ho, Muthalagu Ramanathan, Wichai Chinratanalab, Alison Loren, Linda J Burns, Andrew Artz, Kathleen F Villa, Wael Saber
BACKGROUND: A risk score identifying patients at high risk for veno-occlusive disease (VOD) may aid efforts to study preventive strategies for this uncommon complication of hematopoietic cell transplantation (HCT). METHODS: Patients receiving a first allogeneic HCT between 2008-2013 as reported to the Center for International Blood & Marrow Transplant Research (N=13,097) were randomly divided into training and validation sets. Independent prognostic factors for development of VOD by day+100 post HCT were identified with a multivariate logistic regression model...
June 18, 2018: Biology of Blood and Marrow Transplantation
Cristiane Loiva Reichert, Denise Brentan da Silva, Carlos Alexandre Carollo, Almeriane Maria Weffort-Santos, Cid Aimbiré de Moraes Santos
ETHNOPHARMACOLOGICAL RELEVANCE: Lafoensia pacari A. St.-Hil., belonging to the family Lythraceae and popularly known as 'dedaleira' and 'mangava-brava,' is a native tree of the Brazilian Cerrado, and its barks have been traditionally used as a tonic to treat inflammatory conditions, particularly related to gastric ulcers, wounds or fevers and various types of cancer. AIM OF THE STUDY: We have previously demonstrated the apoptogenic effects of the methanolic extract of L...
June 18, 2018: Journal of Ethnopharmacology
Sarah R Horn, Madison M Long, Benjamin W Nelson, Nicholas B Allen, Philip A Fisher, Michelle L Byrne
One of the most common inflammatory markers examined in depression is C-reactive protein (CRP). However, the magnitude of the association between CRP and depression when controlling for potentially confounding factors such as age, sex, socio-economic status, body mass index, medication and other substance use, and medical illness, is unclear. Inconsistencies in other methodological practices, such as sample collection, assaying, and data cleaning and transformation, may contribute to variations in results. We aggregate studies that examined the association between CRP and depression in two ways...
June 18, 2018: Brain, Behavior, and Immunity
J Kwiatek-Majkusiak, M Geremek, D Koziorowski, R Tomasiuk, S Szlufik, A Friedman
Hepcidin is an essential hormone responsible for the systemic metabolism of iron and simultaneously belongs to the family of the protein mediators of the acute inflammatory response, primarily induced in response to interleukin 6. It can therefore be regarded as a link between the oxidative stress processes, where iron plays an important role, and the processes of neuroinflammation - both considered to be responsible for the neurodegeneration in Parkinson's disease. We assessed the serum level of pro-hepcidin in patients with Parkinson's disease treated only pharmacologically and those treated additionally with deep brain stimulation (DBS) as compared to the control group...
June 18, 2018: Neuroscience Letters
Yazid Belkacemi, Myriam Labopin, Sebastian Giebel, Norbert Claude Gorin, Gokoulakrichenane Loganadane, Leszek Miszczyk, Mauricette Michallet, Gerard Socié, Nicolaas Pm Schaap, Jan J Cornelissen, Ibrahim Yakoub-Agha, Emmanuelle Polge, Mohamad Mohty, Arnon Nagler
PURPOSE: Total-body irradiation (TBI) is a major constituent of myeloablative conditioning regimens. The standard technique consists of 12Gy in 6 fractions over 3 days. The SARASIN study aimed to compare standard-fractionation to one-daily fractionation prior to transplant in leukemia. MATERIAL AND METHODS: We retrospectively compared TBI regimens delivered in 2993 patients from the EBMT database, transplanted between 2000 and 2014 for acute lymphoblastic (ALL, n=1729) or acute myelogenous (AML, n=1264) leukemia...
June 18, 2018: International Journal of Radiation Oncology, Biology, Physics
Bahadir Batar, Isil Bavunoğlu, Yalcin Hacioglu, Mahir Cengiz, Tuba Mutlu, Serap Yavuzer, Hakan Yavuzer, Dilek Cuhadar Ercelebi, Duygu Erhan, Selin Unal, Aydin Tunckale, Mehmet Guven
TMPRSS6 gene mutations can result in iron deficiency anemia (IDA) and cause an increased iron-regulatory hormone, hepcidin, levels. TMPRSS6 encodes a serine protease, matriptase-2, which functions as negative regulatory protein of hepcidin transcription. Thus, TMPRSS6 variations might be risk factors for IDA. The aim of the study was to investigate the association of rs855791, rs4820268, rs5756506, rs2235324, rs2413450, rs2111833, rs228919, and rs733655 SNPs in TMPRSS6 gene with IDA susceptibility and iron-related clinical parameters...
June 18, 2018: Gene
Donald A Leopold, David Elkayam, John C Messina, Colette Kosik-Gonzalez, Per G Djupesland, Ramy A Mahmoud
BACKGROUND: Chronic rhinosinusitis (CRS) is common and sometimes complicated by nasal polyps (NP). Corticosteroid nasal sprays are often unsatisfactory because they are ineffective at delivering medication to high/deep sites of inflammation. OBJECTIVE: Assess whether an exhalation delivery system with fluticasone (EDS-FLU), capable of high/deep drug deposition, improves outcomes. METHODS: Patients (N=323) ≥18 years with moderate-to-severe congestion and NP were randomized to twice-daily EDS-FLU (93, 186, or 372μg) or EDS-placebo for 24 weeks (16 double-blind [DB] plus 8 open-label [OL] when all received 372μg)...
June 18, 2018: Journal of Allergy and Clinical Immunology
Carolyn W Swenson, Neil S Kamdar, Kristian Seiler, Daniel M Morgan, Paul Lin, Sawsan As-Sanie
BACKGROUND: Opioids used for postoperative pain control after surgery have been associated with an increased risk of chronic opioid use. Hysterectomy is the most common major gynecologic procedure in the United States; however, we lack a data-driven definition of new persistent opioid use specific to hysterectomy. OBJECTIVE: 1) Determine a data-driven definition of new persistent opioid use among opioid naïve women undergoing hysterectomy; 2) Determine the prevalence of and risk factors for new persistent opioid use...
June 18, 2018: American Journal of Obstetrics and Gynecology
Xiangcheng Pan, Chunna Lv, Congze He
A rapid oxygen-initiated and -regulated controlled radical polymerization was conducted under ambient temperature and atmosphere. The reaction between triethylborane and oxygen provides ethyl radicals which initiate and mediate the radical polymerization. The controlled radical polymerization was achieved using RAFT chain transfer agents (CTA) without any process of removing oxygen, providing well-defined polymers with almost full conversion (>95%) in short period (15 mins). High-throughput screening was used to discover the suitable conditions for various CTA and monomers...
June 21, 2018: Angewandte Chemie
Takashi Kurita, Kenji Ando, Marehiko Ueda, Satoshi Shizuta, Hideo Okamura, Naoki Matsumoto, Bart Gerritse, Dedra H Fagan, Edward J Schloss, Albert Meijer, Angelo Auricchio, Laurence D Sterns, Ken Okumura
BACKGROUND: The PainFree Smart Shock Technology (SST) study showed a low ICD inappropriate shock rate. However, the majority of patients were from Western countries with patient characteristics different from those in Japan. ICD shock rates using the novel SST algorithms in Japanese patients are still unknown. METHODS: All 2,770 patients in the PainFree SST study (Japan [JPN]: N = 181, other geographies [OJPN]: N = 2,589) were included in this analysis. RESULTS: Japanese patients had higher average LVEF (P < 0...
June 21, 2018: Pacing and Clinical Electrophysiology: PACE
Su-Hyun Han, Hae-Bong Jeong, Kwang-Yeol Park, Hae-Won Shin, Young Chul Youn, SangYun Kim
Choline alphoscerate in clinical studies improved cognitive dysfunction in dementia, but it did not show any clear clinical benefit on mild cognitive impairment (MCI). There is limited evidence of neuropsychological markers in showing the effects of cholinergic precursors in MCI. Object of this preliminary study is to evaluate the change of the P300 latency as a biomarker for cognitive function after taking choline alphoscerate in patients with MCI. Event related evoked potential study were done in baseline (n = 27) and 3 months after taking choline alphoscerate (n = 17)...
June 2018: ENeurologicalSci
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