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C M G van Driel, G H de Bock, M J Schroevers, M J Mourits
OBJECTIVE: To assess the short- and long-term effects of mindfulness-based stress reduction (MBSR) on the resulting quality of life, sexual functioning, and sexual distress after risk-reducing salpingo-oophorectomy (RRSO). DESIGN: Randomized controlled trial. SETTING: A specialized family cancer clinic of the university medical center Groningen. POPULATION: 66 women carriers of the BRCA1/2 mutation who developed at least two moderate-to-severe menopausal symptoms after RRSO...
September 17, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Martha H Mackay, Pamela A Ratner, Gerry Veenstra, Frank X Scheuermeyer, Maja Grubisic, Krishnan Ramanathan, Craig Murray, Karin H Humphries
BACKGROUND: Investigators have identified important racial-identity/ethnicity-based differences in some aspects of acute coronary syndrome (ACS) care and outcomes (time to presentation, symptoms, receipt of coronary angiography/revascularization, repeat revascularization, mortality). Patient-based differences such as pathophysiology and treatment-seeking behaviour account only partly for these outcome differences. We sought to investigate whether there are racial-identity/ethnicity-based variations in the initial emergency department (ED) triage and care of patients with suspected ACS in Canadian hospitals...
September 17, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Á D Rossi, F R Faucz, A Melo, P Pezzuto, G S de Azevedo, B L F Schamber-Reis, J S Tavares, J J Mattapallil, A Tanuri, R S Aguiar, C C Cardoso, C A Stratakis
BACKGROUND: Vertical transmission of Zika virus (ZIKV) is associated with congenital malformations but the mechanism of pathogenesis remains unclear. Although host genetics appear to play a role, no genetic association study has yet been performed to evaluate this question. In order to investigate if maternal genetic variation is associated with Congenital Zika Syndrome (CZS), we conducted a case-control study in a cohort of Brazilian women infected with ZIKV during pregnancy. METHODS: A total of 100 women who reported symptoms of zika during pregnancy were enrolled and tested for ZIKV...
September 17, 2018: Journal of Internal Medicine
Viviane Bernardes de Oliveira Chaiben, Thabata Baechtold da Silveira, Murilo Henrique Guedes, João Pedro de Almeida Fernandes, João Henrique Fregadolli Ferreira, Julianna Beltrão, Giovanna Foltran Leal, Lucas Henrique Olandoski Erbano, Natasha Ludmila Bosch, Roberto Pecoits Filho, Thyago Proença de Moraes, Cristina Pellegrino Baena
INTRODUCTION: The prevalence of chronic kidney disease (CKD) is increasing, with a potential impact in the risk of acceleration of dementia. The potential association between glomerular filtration rate (eGFR) and cognitive performance was scarcely studied. The aim of this study was to evaluate cognitive performance levels across different degrees of kidney function. METHODS: We analyzed 240 outpatients in a nephrology service, classified according to eGFR: Advanced (≤ 30ml/min/1...
September 13, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Julian Vitse, Huidi Tchero, Sylvie Meaume, Anne Dompmartin, Julie Malloizel-Delaunay, Chloé Géri, Christine Faure, Christian Herlin, Luc Teot
Flammacerium is a topical treatment composed of silver sulfadiazine and cerium nitrate initially used in burns. The objective was to assess the effectiveness of silver sulfadiazine and cerium nitrate on ischemic necrosis wounds of the lower limb as an alternative to amputation for a period of 12 weeks. Patients were prospectively randomized to receive silver sulfadiazine and cerium nitrate or standard care. Patients included adults with an ischemic wound of the lower limb, with necrosis covering over at least 50%...
September 2018: International Journal of Lower Extremity Wounds
Kerriann M Casey, Amanda L Johnson, Melea N Hunrath, Jenelle K Fraser, Nicole C McCowan, Katherine Wasson, Rosalinda A Doty, Stephen M Griffey, Denise M Imai
Beginning in 2015, athymic nude sentinel mice from conventional, medium-, and high-security facilities presented to the Comparative Pathology Laboratory (CPL) with weight loss, diarrhea, and/or rectal prolapse. Regardless of whether clinical signs were present or absent, the gross observation of ceco-colonic thickening corresponded histologically to pleocellular typhlocolitis with mucosal hyperplasia and lamina proprial multinucleated cells. A subset of affected sentinels exhibited granulomatous serositis and hepatosplenic necrosis with multinucleated cells...
September 16, 2018: Veterinary Pathology
Ling Yin, Dennis Dubovetsky, Patricia Louzon-Lynch
BACKGROUND: Intradialytic hypotension (IDH) is the most commonly reported complication of hemodialysis (HD) treatment. At our institution, dialysis patients often have both 25% albumin and normal saline ordered as rescue options for management of IDH, without specification of which agent to use first. OBJECTIVE: The purpose of this study was to determine the effect of an algorithm for IDH management. METHODS: A retrospective study was conducted in HD patients who experienced IDH...
September 15, 2018: Annals of Pharmacotherapy
Kirby Sainsbury, Rute Vieira, Jessica Walburn, Falko F Sniehotta, Robert Sarkany, John Weinman, Vera Araujo-Soares
OBJECTIVE: Xeroderma pigmentosum (XP) is a very rare inherited disease; the most important aspect of clinical management is rigorous photoprotection from ultraviolet radiation. The aims of this novel study were to (a) understand and categorize the behavioral complexity and within-participant variability in photoprotection of the face in XP; (b) determine the predictors of photoprotection; and (c) identify individual needs for personalized interventions. METHOD: A total of 20 adults with XP completed an ecological momentary assessment (EMA) study over 50 days...
September 17, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Lars Korn, Cornelia Betsch, Robert Böhm, Nicolas W Meier
OBJECTIVE: Most vaccines provide indirect community protection by preventing the transmission of the disease. Paradoxically, this effect can also motivate omission of vaccination because increasing vaccination rates reduce the risk of infection and, therefore, the individual benefit of vaccination. Consequently, vaccination becomes a social dilemma where individuals' interests conflict with group interests. The current study investigated two social nudge interventions aiming to increasing individuals' motivation to act in the group's interest...
September 17, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Andy Lin, J Jeffry Howbert, William Stafford Noble
To achieve accurate assignment of peptide sequences to observed fragmentation spectra, a shotgun proteomics database search tool must make good use of the very high resolution information produced by state-of-the-art mass spectrometers. However, making use of this information while also ensuring that the search engine's scores are well calibrated -- i.e., that the score assigned to one spectrum can be meaningfully compared to the score assigned to a different spectrum -- has proven to be challenging. Here, we describe a database search score function, the "residue evidence" (res-ev) score, that achieves both of these goals simultaneously...
September 17, 2018: Journal of Proteome Research
Lin Qui, Hui Tan, Hongyan Yin, Jun Zhou, Dengfeng Cheng, Hongcheng Shi
BACKGROUND: The aim was to compare the detect ability of 3 sequential 131I whole-body scans (tri-WBS) on the second, third, and fourth day after 131I therapy for metastatic thyroid cancer. METHODS: Differentiated thyroid cancer patients who received oral high-dose 131I therapy underwent routinely tri-WBS on the second, third, and fourth day after total or near-total thyroidectomy in our hospital. We enrolled 137 patients with 261 tri-WBSs in this study between January 2015 and November 2017...
September 13, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Anna Kaplinsky, Vera Pyatigorskaya, Hila Granot, Ilana Gelernter, Maoz Ben-Ayun, Dror Alezra, Shira L Galper, Zvi Symon, Merav A Ben-David
BACKGROUND: Adjuvant radiotherapy for breast cancer reduces local recurrence and improves survival. In patients with left sided breast cancer, anterior heart position or medial tumor location may cause inadequate breast coverage due to heart shielding. Respiration gating using the Real-time Position Management (RPM) system enables pushing the heart away from the tangential fields during inspiration, thus optimizing the treatment plan. OBJECTIVES: To compare breathing inspiration gating (IG) techniques with free breathing (FB), focusing on breast coverage...
September 2018: Israel Medical Association Journal: IMAJ
Sama Yasin, Yael Sciaky-Tamir, Emad Mostafa, Iris Ohel-Shani, Etty Daniel-Spiegel
INTRODUCTION: Ectopic-pregnancy is a leading cause of pregnancy-related maternal death in the first trimester. Early sonographic diagnostic ability of ectopic-pregnancy is limited. There is an increasing need to identify sonographic markers that can assist with the diagnosis. OBJECTIVES: To characterize the endometrial-pattern by transvaginal-ultrasound as an early marker for ectopic-pregnancy, before demonstration of tubal mass. METHODS: A multicenter prospective study that included 52 women with a positive HCG test, referred to the ultrasound-unit with a diagnosis of pregnancy of unknown location...
September 2018: Harefuah
Baruch Levi, Malke Borow
In 2018, Israel replaced the workforce surveys of the Central Bureau of Statistics with administrative data files, as the source of its reports to the OECD on the number of physicians practicing medicine and their percentage of the population. In the wake of the change, the scope of the medical workforce reported by Israel dropped by approximately 9%-15% in each one of the years from 2012-2015. Furthermore, while according to the previous measurement approach, Israeli figures were consistently equal to or higher than the yearly OECD averages, according to the new method these figures are lower than the averages of other OECD members...
September 2018: Harefuah
Yishai Bachar, Hana Karpin, Galit Dror, Lilach Lieberman, David Dvir, Navah Ratzon
INTRODUCTION: Driving is an essential part of occupational performance. In determining potential driving competence, there is a lack of screening tools to ascertain who should be referred for further assessment in Occupational Therapy or at the Medical Institute for Road Safety. AIMS: To assess the relationship between executive-function, daily-functions and driving behavior measures in unimpaired and neurologically impaired populations. BACKGROUND: Although the research findings were not statistically significant, the trend points to the correlation between executive-function measures and self-report driving ability...
September 2018: Harefuah
Joseph Cyrus Parambeth, Geoffrey T Fosgate, Jan S Suchodolski, Jonathan A Lidbury, Jörg M Steiner
BACKGROUND: Pancreatic enzyme supplements for the treatment of exocrine pancreatic insufficiency (EPI) in dogs can be uncoated or enteric coated. Enteric coated supplements might be advantageous. HYPOTHESIS/OBJECTIVES: Enteric coated enzyme supplements are superior to uncoated supplements in dogs with clinical EPI. ANIMALS: Eleven dogs with naturally occurring EPI that were apparently free from other diseases. METHODS: Randomized, blinded, controlled cross-over clinical trial comparing a novel micro-encapsulated enteric coated enzyme supplement to a commercially available uncoated product in dogs with clinical EPI...
September 17, 2018: Journal of Veterinary Internal Medicine
Marine Azevedo Da Silva, Nadia Younès, Ariane Leroyer, Laurent Plancke, Cédric Lemogne, Marcel Goldberg, Mathieu Rivière, Maria Melchior
Objective Most suicides occur among individuals of working age. Risk is elevated in some occupational groups, however relations between long-term occupational trajectories and suicide are not well known. We describe career-long occupational trajectories and examine their influence on suicide. Methods Data come from GAZEL, a French cohort study set among employees of a large national utilities company. Occupational grade was obtained from company records from the time of hiring (1953‒1988). Group-based trajectory models were used to define occupational trajectories over a mean time period of 25...
September 16, 2018: Scandinavian Journal of Work, Environment & Health
Riza Gurhan Isil, Mehmet Mihmanli, Pinar Yazici, Canan Tulay Isil, Uygar Demir, Cemal Kaya, Ozgur Bostanci
BACKGROUND: Roux-en-Y gastric bypass (RYGB) has been considered as the most efficient method in bariatric surgery. Indeed, Laparoscopic Sleeve Gastrectomy (LSG) which is easier to do, has been increasingly used in the recent years. The aim of the present study was to compare short-and mid-term outcomes of RYGB and LSG. METHODS: Medical records of 62 patients who underwent either RYGB (GroupR) or LSG (GroupL) in our General Surgery Department between 2010 and 2013 were retrospectively reviewed...
July 31, 2018: Annali Italiani di Chirurgia
Madara Tirzīte, Māris Bukovskis, Gunta Strazda, Normunds Jurka, Immanuels Taivans
Lung cancer is a very common malignancy with a low five-year survival rate. Artificial olfactory sensor (electronic nose) is a tool that recently has been studied as a probable optimal screening tool for early detection of lung cancer, but still no statistical method has been put forward as the preferable one.
 The aim of the study was to explore the use of logistic regression analysis to analyse patients' exhaled breath samples with electronic nose in order to differentiate lung cancer patients (regardless of the stage of the cancer) from patients with other lung diseases and healthy individuals...
September 17, 2018: Journal of Breath Research
V Tsiouris, I Georgopoulou, C Batzios, N Pappaioannou, R Ducatelle, P Fortomaris
Heat stress is a physical environmental stressor, which can affect performance, health and welfare of poultry. The aim of the present study was to investigate the effect of cyclic acute heat stress as a predisposing factor for necrotic enteritis in broiler chicks in an experimental challenge model. Two hundred and forty broiler chicks were randomly allocated to four treatment groups according to the following experimental design: group A, was served as negative control (25 o C), group B, birds were subjected to cyclic acute heat stress (35 o C), group C, birds were challenged and group D, birds were both subjected to heat stress and challenged...
September 17, 2018: Avian Pathology: Journal of the W.V.P.A
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