Claudio Peter D'Incal, Dale John Annear, Ellen Elinck, Jasper J van der Smagt, Mariëlle Alders, Alexander J M Dingemans, Ligia Mateiu, Bert B A de Vries, Wim Vanden Berghe, R Frank Kooy
Mutations in ADNP result in Helsmoortel-Van der Aa syndrome. Here, we describe the first de novo intronic deletion, affecting the splice-acceptor site of the first coding ADNP exon in a five-year-old girl with developmental delay and autism. Whereas exome sequencing failed to detect the non-coding deletion, genome-wide CpG methylation analysis revealed an episignature suggestive of a Helsmoortel-Van der Aa syndrome diagnosis. This diagnosis was further supported by PhenoScore, a novel facial recognition software package...
February 29, 2024: European Journal of Human Genetics: EJHG