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https://www.readbyqxmd.com/read/29344218/atra-increases-iodine-uptake-and-inhibits-the-proliferation-and-invasiveness-of-human-anaplastic-thyroid-carcinoma-sw1736-cells-involvement-of-%C3%AE-catenin-phosphorylation-inhibition
#1
Ling Lan, Spyros Basourakos, Dai Cui, Xuemei Zuo, Wei Deng, Lili Huo, Hailing Chen, Guoying Zhang, Lili Deng, Bingyin Shi, Yong Luo
All-trans-retinoic acid (ATRA) can enhance iodine uptake capability of thyroid tumors, but the mechanisms remain poorly understood. The aim of the present study was to investigate the effects of ATRA on isotope susceptibility, proliferation and invasion of anaplastic thyroid carcinoma (ATC) and potential mechanisms. SW1736 cells were treated with 1 µmol/l ATRA or 1% ethanol for 5 days. A cell line stably expressing β-catenin-shRNA was established. An iodine uptake assay was performed using 125I. Proliferation and invasiveness were tested using MTT and Transwell assays, respectively...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344184/therapeutic-effects-of-adenovirus-mediated-cd-and-nis-expression-combined-with-na131i-5-fc-on-human-thyroid-cancer
#2
Meng-Hui Yuan, Long-Xiao Wei, Run-Suo Zhou, Hai-Feng Xu, Jun-Yan Wang, Qian-Rong Bai
Thyroid cancer is the most common type of malignant endocrine tumor diagnosed. Previous studies have indicated that gene therapy is the most promising and effective therapeutic method for thyroid cancer. Therefore, in the present study, Na131I/5-fluorocytosine (5-FC) treatment was combined with cytosine deaminase (CD, encoded by the CDA gene) and sodium iodide symporter (NIS, encoded by the SLC5A5 gene) to act together as a therapeutic tool for thyroid cancer. The present study explored the combined cytotoxic effects of adenovirus-mediated CD and NIS under the control of the progression elevated gene-3 (PEG-3) promoter (Ad-PEG-3-CD-NIS) with Na131I/5-FC against the human thyroid cancer TT cell line in vitro...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29341392/cannabis-use-is-associated-with-reduced-prevalence-of-progressive-stages-of-alcoholic-liver-disease
#3
Adeyinka Charles Adejumo, Tokunbo Opeyemi Ajayi, Oluwole Muyiwa Adegbala, Kelechi Lauretta Adejumo, Samson Alliu, Akintunde Micheal Akinjero, Nnaemeka Egbuna Onyeakusi, Ogooluwa Ojelabi, Terence Ndonyi Bukong
BACKGROUND: Abusive alcohol use has well-established health risks including causing liver disease (ALD) characterized by alcoholic steatosis (AS), steatohepatitis (AH), fibrosis, cirrhosis (AC) and hepatocellular carcinoma (HCC). Strikingly, a significant number of individuals who abuse alcohol also use Cannabis, which has seen increased legalization globally. While cannabis has demonstrated anti-inflammatory properties, its combined use with alcohol and the development of liver disease remains unclear...
January 17, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29333850/engineering-nis-ni2p-heterostructures-for-efficient-electrocatalytic-water-splitting
#4
Xin Xiao, Dekang Huang, Yong Qing Richard Fu, Ming Wen, Xingxing Jiang, Xiaowei Lv, Man Li, Lin Gao, Shuangshuang Liu, Mingkui Wang, Chuan Zhao, Yan Shen
Developing high-active and low-cost bifunctional materials for catalyzing hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) holds pivotal role in water splitting. Therefore, we present a new strategy to form NiS/Ni2P heterostructures. The as-obtained NiS/Ni2P/CC requires overpotentials of 111 mV for the HER and 265 mV for the OER to reach a current density of 20 mA cm-2, outperforming their counterparts such as NiS and Ni2P under the same conditions. Additionally, the NiS/Ni2P/CC electrode requires a 1...
January 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29330969/is-salinity-an-obstacle-for-biological-invasions
#5
Filipa Paiva, Andrea Barco, Yiyong Chen, Alireza Mirzajani, Farrah T Chan, Velda Lauringson, Miguel Baltazar-Soares, Aibin Zhan, Sarah A Bailey, Jamileh Javidpour, Elizabeta Briski
Invasions of freshwater habitats by marine and brackish species have become more frequent in recent years with many of those species originating from the Ponto-Caspian region. Populations of Ponto-Caspian species have successfully established in the North and Baltic Seas and their adjoining rivers, as well as in the Great Lakes-St. Lawrence River region. To determine if Ponto-Caspian taxa more readily acclimatize to and colonize diverse salinity habitats than taxa from other regions, we conducted laboratory experiments on 22 populations of eight gammarid species native to the Ponto-Caspian, Northern European and Great Lakes-St...
January 13, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29325434/collection-of-real-world-data-on-nivolumab-s-effectiveness-in-renal-cell-carcinoma-rationale-for-an-observational-study
#6
Jens Bedke, Marc-Oliver Grimm, Viktor Grünwald
Renal cell carcinoma (RCC) represents the seventh (men) respectively tenth (women) most frequent cancer in western countries. After one or more lines of VEGF-targeted therapy, immunotherapy with nivolumab is strongly recommended in patients with metastatic RCC. Nivolumab is the first, and so far, only approved programmed death 1 (PD-1) immune checkpoint inhibitor to demonstrate a gain in overall survival in RCC. We describe herein design and rationale of trial CA209653 ('NIS NORA'), a prospective, noninterventional cohort study investigating the effectiveness of nivolumab...
January 12, 2018: Future Oncology
https://www.readbyqxmd.com/read/29322961/perioperative-strokes-following-combined-coronary-artery-bypass-grafting-and-carotid-endarterectomy-a-nationwide-perspective
#7
REVIEW
Reshmi Udesh, Hannah Cheng, Amol Mehta, Parthasarathy D Thirumala
BACKGROUND: To assess the risk of perioperative stroke on in-hospital morbidity and mortality following combined coronary artery bypass grafting (CABG) and carotid endarterectomy (CEA). MATERIALS AND METHODS: Data from the National Inpatient Sample (NIS) database for all patients who underwent CABG with CEA were identified using ICD-9 codes. Combined procedures were identified as CEA and CABG procedures that happened on the same day. Various preoperative and perioperative risk factors and their association with in-hospital mortality and morbidity were studied...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29321887/habitat-formation-prevails-over-predation-in-influencing-fouling-communities
#8
Jean-Charles Leclerc, Frédérique Viard
Coastal human-made structures, such as marinas and harbors, are expanding worldwide. Species assemblages described from these artificial habitats are novel relative to natural reefs, particularly in terms of the abundance of nonindigenous species (NIS). Although these fouling assemblages are clearly distinctive, the ecosystem functioning and species interactions taking place there are little understood. For instance, large predators may influence the fouling community development either directly (feeding on sessile fauna) or indirectly (feeding on small predators associated with these assemblages)...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29318626/trends-and-predictors-of-implantable-cardioverter-defibrillator-implantation-after-sudden-cardiac-arrest-insight-from-the-national-inpatient-sample
#9
Muhammad Bilal Munir, Fahad Alqahtani, Sami Aljohani, Ashwin Bhirud, Sujal Modi, Mohamad Alkhouli
BACKGROUND: Implantable cardioverter defibrillator (ICD) has a class IA indication in survivors of sudden cardiac arrest (SCA) provided no reversible cause is identified. We sought to determine trends and predictors of ICD implant in SCA patients from a national sample of United States population. METHODS AND RESULTS: Data was gathered from National Inpatient Sample (NIS) from January 2003 to December 2014. All patients ≥ 18 years of age with a primary discharge diagnosis of SCA, ventricular fibrillation (VF), ventricular flutter, and ventricular tachycardia (VT) were included...
January 9, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29312837/recreational-marijuana-use-and-acute-myocardial-infarction-insights-from-nationwide-inpatient-sample-in-the-united-states
#10
Rupak Desai, Upenkumar Patel, Shobhit Sharma, Parth Amin, Rushikkumar Bhuva, Malav S Patel, Nitin Sharma, Manan Shah, Smit Patel, Sejal Savani, Neha Batra, Gautam Kumar
Background Marijuana is a widely used recreational substance. Few cases have been reported of acute myocardial infarction following marijuana use. To our knowledge, this is the first ever study analyzing the lifetime odds of acute myocardial infarction (AMI) with marijuana use and the outcomes in AMI patients with versus without marijuana use. Methods We queried the 2010-2014 National Inpatient Sample (NIS) database for 11-70-year-old AMI patients. Pearson Chi-square test for categorical variables and Student T-test for continuous variables were used to compare the baseline demographic and hospital characteristics between two groups (without vs...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29312714/off-vs-on-pump-coronary-artery-bypass-graft-surgery-on-hospital-outcomes-in-134-117-octogenarians
#11
Umberto Benedetto, Gianni D Angelini, Massimo Caputo, Dmitriy N Feldman, Luke K Kim, Christopher Lau, Antonino Di Franco, Leonard N Girardi, Mario Gaudino
Background: In octogenarian patients there is a potential for more tangible clinical benefits from off-pump coronary artery bypass (OPCAB) compared to conventional coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) (COCAB). We aimed to investigate whether, compared to COCAB, OPCAB is associated with better operative outcomes in octogenarians by analyzing the Nationwide Inpatient Sample (NIS) databases 2003-2011. Methods: Of the 134,117 discharge records from 797 hospitals analyzed of patients aged ≥80 years undergoing first time isolated CABG from 2003 to 2011, 70...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29299482/have-the-annual-trends-of-total-hip-arthroplasty-in-rheumatoid-arthritis-patients-decreased
#12
Kemjika O Onuoha, Max Solow, Jared M Newman, Nipun Sodhi, Robert Pivec, Anton Khlopas, Assem A Sultan, Morad Chughtai, Neil V Shah, Jaiben George, Michael A Mont
Background: Rheumatoid arthritis (RA) is characterized by chronic systemic and synovial inflammation, resulting in damage to both cartilage and bone. Medical treatment, which has increasingly relied upon disease modifying anti-rheumatic drugs (DMARDs), may fail to slow disease progression and limit joint damage, ultimately warranting surgical intervention. Up to 25% of RA patients will require lower extremity total joint arthroplasty. Though total hip arthroplasty (THA) is known to improve quality of life and functional measures, clarification is still required with respect to the impact of increased DMARD use on annual rates of THA...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29299476/have-the-annual-trends-of-total-knee-arthroplasty-in-ankylosing-spondylitis-patients-decreased
#13
Roby Abraham, John J Kelly, Jared M Newman, Qais Naziri, Nipun Sodhi, Anton Khlopas, Jaiben George, Neil V Shah, Assem A Sultan, Morad Chughtai, John W Barrington, Carl B Paulino, Michael A Mont
Background: Ankylosing spondylitis (AS) is characterized by osteoproliferation-induced structural damage and spinal inflammation, which lead to spinal deformity and functional disability. Though AS commonly affects the axial skeleton and sacroiliac joints, up to 70% of patients have involvement of the knees and other joints. Despite pharmacological efforts, advancing joint involvement may ultimately require surgical intervention. Total knee arthroplasty (TKA) is effective in managing patients with AS, yet it remains unclear whether or not the annual rates of TKA have been affected...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29299444/temporal-trends-and-outcomes-of-acute-myocardial-infarction-in-patients-with-cancer
#14
Naga Venkata Pothineni, Nishi N Shah, Yogita Rochlani, Marwan Saad, Swathi Kovelamudi, Konstantinos Marmagkiolis, Sabha Bhatti, Mehmet Cilingiroglu, Wilbert S Aronow, Abdul Hakeem
Background: Data on outcomes of ST-elevation myocardial infarction (STEMI) in patients with cancer are scarce. We investigated the nationwide trends in admissions for STEMI, utilization of percutaneous coronary intervention (PCI), and in-hospital outcomes in patients with the three most common cancer diagnoses (lung, breast, and colon) compared to patients without cancer. Methods: We conducted an administrative database study using the Nationwide Inpatient Sample (NIS)...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29298843/nis-expression-in-thyroid-tumors-relation-with-prognosis-clinicopathological-and-molecular-features
#15
Catarina Tavares, Maria João Coelho, Catarina Eloy, Miguel Melo, Adriana Gaspar da Rocha, Ana Pestana, Rui Batista, Luciana Bueno Ferreira, Elisabete Rios, Samia Selmi-Ruby, Bruno Cavadas, Luísa Pereira, Manuel Sobrinho Simões, Paula Soares
Thyroid cancer therapy is based on surgery followed by radioiodine treatment. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS) (codified by the SLC5A5 gene), that is functional only when targeted to the cell membrane. We aimed to evaluate if NIS expression in thyroid primary tumors would be helpful in predicting tumor behavior, response to therapy and prognosis. NIS expression was addressed by qPCR and immunohistochemistry. In order to validate our data, we also studied SLC5A5 expression on 378 primary papillary thyroid carcinomas from The Cancer Genome Atlas (TCGA) database...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29297222/self-supported-ternary-ni-s-se-nanorod-arrays-as-highly-active-electrocatalyst-for-hydrogen-generation-in-both-acidic-and-basic-medium%C3%AF-experiment-investigation-and-dft-calculation
#16
Huijie Meng, Wenjuan Zhang, Zizai Ma, Fei Zhang, Bin Tang, Jinping Li, Xiaoguang Wang
In this paper, a novel three-dimensional self-supported ternary NiS-Ni9S8-NiSe nanorod (NR) array cathode has been successfully in-situ constructed by a two-step hydrothermal route. When applied to hydrogen evolution, the synthesized NiS-Ni9S8-NiSe-NR electrode demonstrates optimized electrocatalytic activity and long-term durability, only requiring overpotentials as low as 120 mV and 112 mV to drive 10 mA cm-2 for hydrogen evolution reaction in 0.5 M H2SO4 and 1.0 M KOH, respectively. DFT calculation reveals that, after Se doping, Se 3d orbitals are bonded to Ni 3d orbitals and S p orbitals near Fermi level, attesting a significant electron transfer between nickel and selenium atom...
January 3, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29295741/phytoplankton-diversity-in-adriatic-ports-lessons-from-the-port-baseline-survey-for-the-management-of-harmful-algal-species
#17
Patricija Mozetič, Monica Cangini, Janja Francé, Mauro Bastianini, Fabrizio Bernardi Aubry, Mia Bužančić, Marina Cabrini, Federica Cerino, Marijeta Čalić, Raffaele D'Adamo, Dragana Drakulović, Stefania Finotto, Daniela Fornasaro, Federica Grilli, Romina Kraus, Nataša Kužat, Daniela Marić Pfannkuchen, Živana Ninčević Gladan, Marinella Pompei, Ana Rotter, Irene Servadei, Sanda Skejić
An inventory of phytoplankton diversity in 12 Adriatic ports was performed with the port baseline survey. Particular emphasis was put on the detection of harmful aquatic organisms and pathogens (HAOP) because of their negative impact on ecosystem, human health, and the economy. Phytoplanktonic HAOP are identified as species, either native or non-indigenous (NIS), which can trigger harmful algal blooms (HAB). A list of 691 taxa was prepared, and among them 52 were classified as HAB and five as NIS. Records of toxigenic NIS (Pseudo-nitzschia multistriata, Ostreopsis species including O...
December 30, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29280482/national-trends-in-primary-tracheoesophageal-puncture-after-total-laryngectomy
#18
Rosh K V Sethi, Daniel G Deschler
OBJECTIVES/HYPOTHESIS: Tracheoesophageal puncture (TEP) can be performed at the time of laryngectomy (primary) or postoperatively (secondary). Prior studies demonstrate safe and earlier voice acquisition and rehabilitation with primary TEP. The objectives of this study were to assess national trends in primary TEP and identify factors associated with its use. STUDY DESIGN: Retrospective review. METHODS: Retrospective analysis of the Nationwide Inpatient Sample (NIS) from 2010 to 2014 was performed...
December 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29274953/non-indigenous-macrozoobenthic-species-on-hard-substrata-of-selected-harbours-in-the-adriatic-sea
#19
A Spagnolo, R Auriemma, T Bacci, I Balković, F Bertasi, L Bolognini, M Cabrini, L Cilenti, C Cuicchi, I Cvitković, M Despalatović, F Grati, L Grossi, A Jaklin, L Lipej, O Marković, B Mavrič, B Mikac, F Nasi, V Nerlović, S Pelosi, M Penna, S Petović, E Punzo, A Santucci, T Scirocco, P Strafella, B Trabucco, A Travizi, A Žuljević
The intense shipping traffic characterising the Adriatic Sea favours the spread of marine organisms. Yet, a study of 12 Adriatic ports (4 on the western side and 8 on the eastern side of the basin) found that non-indigenous species (NIS) accounted for only 4% of the benthic communities settled on hard substrates. The cirripeds Amphibalanus amphitrite and Balanus trigonus, found in 8 harbours, were the most common invaders followed by Amphibalanus eburneus, the ascidian Styela plicata, and the bivalve Magallana gigas...
December 20, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29248382/risk-factors-for-nosocomial-infections-after-cardiac-surgery-in-newborns-with-congenital-heart-disease
#20
Heladia García, Beatriz Cervantes-Luna, Héctor González-Cabello, Guadalupe Miranda-Novales
BACKGROUND: Congenital heart diseases are among the most common congenital malformations. Approximately 50% of the patients with congenital heart disease undergo cardiac surgery. Nosocomial infections (NIs) are the main complications and an important cause of increased morbidity and mortality associated with congenital heart diseases. This study's objective was to identify the risk factors associated with the development of NIs after cardiac surgery in newborns with congenital heart disease...
November 23, 2017: Pediatrics and Neonatology
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