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https://www.readbyqxmd.com/read/28730770/characteristics-and-outcomes-of-patients-with-multifocal-multicentric-and-unifocal-breast-cancer
#1
Lidija Djordjevic-Jovanovic, Aleksandar Karanikolic, Toplica Bojic, Ivan Pesic, Miodrag Djordjevic, Mirjana Marinkovic
PURPOSE: The clinical behavior and outcome of multifocal (MF) and multicentric (MC) breast tumors are not well characterized. The purpose of this study was to compare the prognosis of MF/MC tumors with unifocal (UF)tumors and its correlation with other pathological characteristics and patient outcomes. METHODS: Eighty-three patients with MC/MF breast cancer and 501 with UF breast cancer treated at the Surgical Clinic Nis were studied. We compared MC/MF and UF breast cancer patients with respect to demographics, tumor characteristics- adjuvant systemic therapy, local recurrence-free survival (LRFS) and overall survival (OS)...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28726327/changing-metrics-of-organ-procurement-organization-performance-in-order-to-increase-organ-donation-rates-in-the-united-states
#2
D Goldberg, M J Kallan, L Fu, M Ciccarone, J Ramirez, P Rosenberg, J Arnold, G Segal, K P Moritsugu, H Nathan, R Hasz, P L Abt
The shortage of deceased-donor organs is compounded by donation metrics that fail to account for the total pool of possible donors, leading to ambiguous donor statistics. We sought to assess potential metrics of organ procurement organizations (OPOs) utilizing data from the Nationwide Inpatient Sample (NIS) from 2009-2012 and State Inpatient Databases (SIDs) from 2008-2014. A possible donor was defined as a ventilated inpatient death ≤75 years of age, without multi-organ system failure, sepsis, or cancer, whose cause of death was consistent with organ donation...
July 20, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28712558/catheter-ablation-of-accessory-pathway-14-year-trends-in-utilization-and-complications-in-adults-in-the-united-states
#3
Jalaj Garg, Neeraj Shah, Parasuram Krishnamoorthy, Kathan Mehta, Babak Bozorgnia, Noel G Boyle, Ronald Freudenberger, Andrea Natale
BACKGROUND: The aim of this study was to determine the temporal trends in utilization of catheter ablation of accessory pathways in the United States. METHODS: All patients from the Nationwide Inpatient Sample (NIS) ≥18years of age with a primary diagnosis of anomalous atrioventricular excitation syndrome (International Classification of Diseases, Ninth Edition, Clinical Modification [ICD-9-CM] code 426.7) were included in the study. Patients who underwent catheter ablation were identified using ICD-9-CM procedure code 37...
June 30, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28711540/in-hospital-complications-following-lumbar-spine-surgery-in-patients-with-parkinson-s-disease-evaluation-of-the-national-inpatient-sample-database
#4
Joseph F Baker, Shearwood McClelland, Breton G Line, Justin S Smith, Robert A Hart, Christopher P Ames, Chris Shaffrey, Shay Bess
BACKGROUND: Previous reports suggest that patients with Parkinson's disease (PD) have increased complication rates following spine surgery however data from these reports are limited by small patient size. The aim of this study was to utilize the National Inpatient Sample (NIS) database to compare in-hospital complications for PD compared to patients without following elective lumbar spine surgery. METHODS: The NIS database was accessed to find patients who underwent lumbar spine surgery with and without a diagnosis of PD...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28709851/waves-of-change-national-trends-in-surgical-management-of-male-stress-incontinence
#5
Susan MacDonald, Marc Colaco, Ryan Terlecki
OBJECTIVE: To determine the national trend in surgical management of male stress urinary incontinence (SUI) in the context of the rate of radical prostatectomy (RP) as reported by a national database. Traditionally the artificial urinary sphincter (AUS) has been the gold standard of surgical management, but the male sling represents a newer and popular alternative. Refinements in prostate surgery may reduce the incidence and degree of subsequent SUI. MATERIALS AND METHODS: A retrospective cross sectional analysis was performed using the National Inpatient Survey (NIS) database, which captures discharge data from inpatient and overnight admissions...
July 11, 2017: Urology
https://www.readbyqxmd.com/read/28706426/healthcare-utilization-and-costs-associated-with-gastroparesis
#6
Vaibhav Wadhwa, Dhruv Mehta, Yash Jobanputra, Rocio Lopez, Prashanthi N Thota, Madhusudhan R Sanaka
AIM: To use a national database of United States hospitals to evaluate the incidence and costs of hospital admissions associated with gastroparesis. METHODS: We analyzed the National Inpatient Sample Database (NIS) for all patients in whom gastroparesis (ICD-9 code: 536.3) was the principal discharge diagnosis during the period, 1997-2013. The NIS is the largest publicly available all-payer inpatient care database in the United States. It contains data from approximately eight million hospital stays each year...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28706256/an-extremely-high-dietary-iodide-supply-forestalls-severe-hypothyroidism-in-na-i-symporter-nis-knockout-mice
#7
Giuseppe Ferrandino, Rachel R Kaspari, Andrea Reyna-Neyra, Nabil E Boutagy, Albert J Sinusas, Nancy Carrasco
The sodium/iodide symporter (NIS) mediates active iodide (I(-)) accumulation in the thyroid, the first step in thyroid hormone (TH) biosynthesis. Mutations in the SLC5A5 gene encoding NIS that result in a non-functional protein lead to congenital hypothyroidism due to I(-) transport defect (ITD). ITD is a rare autosomal disorder that, if not treated promptly in infancy, can cause mental retardation, as the TH decrease results in improper development of the nervous system. However, in some patients, hypothyroidism has been ameliorated by unusually large amounts of dietary I(-)...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704352/racial-and-geographic-differences-in-breastfeeding-united-states-2011-2015
#8
Erica H Anstey, Jian Chen, Laurie D Elam-Evans, Cria G Perrine
Breastfeeding provides numerous health benefits for infants and mothers alike. The American Academy of Pediatrics recommends exclusive breastfeeding for approximately the first 6 months of life and continued breastfeeding with complementary foods through at least the first year (1). National estimates indicate substantial differences between non-Hispanic black (black) and non-Hispanic white (white) infants across breastfeeding indicators in the United States (2). CDC analyzed 2011-2015 National Immunization Survey (NIS) data for children born during 2010-2013 to describe breastfeeding initiation, exclusivity through 6 months and duration at 12 months among black and white infants...
July 14, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28702686/disparities-in-epilepsy-surgery-in-the-united-states-of-america
#9
Iván Sánchez Fernández, Christopher Stephen, Tobias Loddenkemper
The aim is to describe the epidemiology of epilepsy surgery in children and adults in the United States. We performed a descriptive study of the National Inpatient Sample (NIS) for the year 2012 and the Kids' Inpatient Database (KID) for the period 2010-2012, the largest all-payer databases on inpatient data in the USA. These databases estimate 97% of all inpatient hospital discharges in the USA. In the KID, 12,899 (0.2%) of admission records had brain surgery and 600 of the 4900 (12.2%) admissions with focal refractory epilepsy underwent epilepsy surgery...
July 12, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28702576/nuclear-inelastic-scattering-and-density-functional-theory-studies-of-a-one-dimensional-spin-crossover-fe-1-2-4-triazole-2-1-2-4-triazolato-bf4-molecular-chain
#10
Kevin Jenni, Lena Scherthan, Isabelle Faus, Jennifer Marx, Cornelius Strohm, Marcus Herlitschke, Hans-Christian Wille, Peter Würtz, Volker Schünemann, Juliusz A Wolny
Nuclear inelastic scattering (NIS) experiments have been performed in order to study the vibrational dynamics of the low- and high-spin states of the polynuclear 1D spin crossover compound [Fe(1,2,4-triazole)2(1,2,4-triazolato)](BF4) (1). Density functional theory (DFT) calculations using the functional B3LYP* and the basis set CEP-31G for heptameric and nonameric models of the compound yielded the normal vibrations and electronic energies for high-spin and low-spin isomers of three models differing in the distribution of anionic trz(-) ligands and BF4(-) anions...
July 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28695972/the-incidence-of-postoperative-pneumonia-in-various-surgical-subspecialties-a-dual-database-analysis
#11
Morad Chughtai, Chukwuweike U Gwam, Anton Khlopas, Jared M Newman, Gannon L Curtis, Pedro A Torres, Rafay Khan, Michael A Mont
INTRODUCTION: Pneumonia is the third most common postoperative complication. However, its epidemiology varies widely and is often difficult to assess. For a better understanding, we utilized two national databases to determine the incidence of postoperative pneumonia after various surgical procedures. Specifically, we used the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) and the Nationwide Inpatient Sample (NIS) to determine the incidence and yearly trends of postoperative pneumonia following orthopaedic, urologic, otorhinolaryngologic, cardiothoracic, neurosurgery, and general surgeries...
July 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28695929/biomolecule-mediated-hydrothermal-synthesis-of-polyoxoniobate-cds-nanohybrids-with-enhanced-photocatalytic-performance-for-hydrogen-production-and-rhb-degradation
#12
Meiying Liu, Hong Chen, Hongmei Zhao, Yunfei He, Yunhe Li, Ran Wang, Lancui Zhang, Wansheng You
Using a biomolecule of l-cystine as the sulfur source and coordinating agent, polyoxoniobate-CdS nanohybrids were successfully synthesized under mild hydrothermal conditions. The adsorption of ammonium group (-NH2) in l-cystine molecular structure on the surface of CdS renders the amine-anchored CdS positively charged, which readily combines with the negatively charged polyoxoniobate clusters in terms of the electrostatic interaction. The as-obtained polyoxoniobate-CdS nanohybrids exhibit much superior activity for H2 evolution and RhB degradation under visible light as compared to the unhybridized CdS and polyoxoniobate...
July 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28691501/factors-contributing-to-hospital-stay-and-total-inpatient-charges-in-total-ankle-arthroplasty-review-of-the-national-inpatient-sample
#13
Jason L Codding, Benjamin M Zmistowski, Daniel E Davis, Mitchell G Maltenfort, David I Pedowitz
Total ankle arthroplasty (TAA) is commonly performed for end-stage ankle osteoarthritis. Given rising costs and declining reimbursements, identifying variables increasing length of stay (LOS) and total inpatient charges (TICs) of TAA is necessary for providing cost-effective care. The National Inpatient Sample (NIS) database was reviewed between 1993 and 2010, identifying LOS and TIC for TAA. Using a multivariate analysis, patient comorbidities, demographics, payment, and hospital details were evaluated. Median LOS decreased from 5 to 2 days, whereas median TICs increased from $21 382...
July 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28688539/us-regional-and-demographic-differences-in-prescription-opioid-and-heroin-related-overdose-hospitalizations
#14
George Jay Unick, Daniel Ciccarone
BACKGROUND: US opioid overdose death rates have increased between 2000 and 2014. While, the increase in prescription opioid use has been linked to the increase in heroin use, there are reasons to view this relationship as a partial explanation for the recent increase in heroin-related harms. This study documents the differences in trends in prescription opioid overdose-related (POD) and heroin overdose-related (HOD) hospitalizations. METHODS: Data come from the National Inpatient Sample (NIS) for the years 2000 through 2014...
July 5, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28682619/structure-reactivity-relationships-of-conformationally-armed-disaccharide-donors-and-their-use-in-the-synthesis-of-a-hexasaccharide-related-to-the-capsular-polysaccharide-from-streptococcus-pneumoniae-type-37
#15
Thibault Angles d'Ortoli, Christoffer Hamark, Göran Widmalm
To advance the field of glycobiology, efficient synthesis methods of oligosaccharides and glycoconjugates are a requisite. In glycosylation reactions using superarmed donors, both selectivity and reactivity issues must be considered, and we herein investigate these aspects for differently protected β-linked 2-O-glycosylated glucosyl donors carrying bulky tert-butyldimethylsilyl groups to different extents. The acceptors in reactions being secondary alcohols presents a challenging situation with respect to steric crowding...
July 19, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28682077/nis-mediated-cross-coupling-of-c-sp-2-h-and-n-h-bonds-a-transition-metal-free-approach-toward-indolo-1-2-a-quinazolinones
#16
Sindhura Badigenchala, Govindasamy Sekar
A metal- and base-free protocol for intramolecular cross-coupling of C(sp(2))-H and N-H bonds using N-iodosuccinimide (NIS) has been demonstrated. This environmentally benign approach furnishes a series of substituted indolo[1,2-a]quinazolinones from the suitably fabricated indoles via C-N bond forming cyclization in 28-82% yield. A plausible mechanism is proposed for this cyclization based on the results of a control experiment. This methodology requires no additional metal catalyst, oxidant, or base. Furthermore, the synthetic utility of the protocol is demonstrated by performing a gram scale reaction...
July 6, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28680726/predominantly-negative-impact-of-diabetes-on-spinal-surgery-a-review-and-recommendation-for-better-preoperative-screening
#17
REVIEW
Nancy E Epstein
BACKGROUND: For patients undergoing spine surgery, the literature attributes significant increased perioperative risks/adverse events (AE) complications, longer length of stay (LOS), and higher 30-day readmission/reoperation rates to those with diabetes. Diabetics are often divided into those with insulin dependent diabetes (IDDM), and non-insulin dependent diabetes (NIDD). However, other series also compare those with uncontrolled diabetes (UCDM) vs. those with controlled DM (CDM). METHODS: We found a marked variation in the size and quality of studies identified in PubMed regarding the impact of diabetes on spinal surgery (e...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28679325/multiparametric-mri-in-men-with-clinical-suspicion-of-prostate-cancer-undergoing-repeat-biopsy-a-prospective-comparison-with-clinical-findings-and-histopathology
#18
Lars Boesen, Nis Nørgaard, Vibeke Løgager, Ingegerd Balslev, Henrik S Thomsen
Background Multiparametric magnetic resonance imaging (mpMRI) can improve detection of clinically significant prostate cancer (csPCa). Purpose To compare mpMRI score subgroups to systematic transrectal ultrasound-guided biopsies (TRUSbx) and prostate-specific antigen (PSA)-based findings for detection of csPCa in men undergoing repeat biopsies. Material and Methods MpMRI was performed prior to re-biopsy in 289 prospectively enrolled patients. All underwent repeat TRUSbx followed by targeted biopsies (MRITB) of any mpMRI-identified lesion...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28676312/multiple-sclerosis-frequency-cost-and-economic-burden-in-the-united-states
#19
Alex Y Chen, Amy O Chonghasawat, Kevin L Leadholm
Multiple sclerosis (MS) is one of the most common neurological diseases, affecting young and middle-aged adults. The full economic cost of managing chronic MS is substantial. To investigate the recent trend of medical cost and economic burden of MS management in the United States (U.S.), we inquired for available data from the National Inpatient Sample database (NIS; from 1994 to 2013). The annual rates of changes were determined by linear regression analysis. We found an estimated half million increase in MS admissions, annually, which was projected to exceed 43...
July 1, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28670511/radioactive-iodine-therapy-and-glucose-tolerance
#20
REVIEW
Roghaieh Samadi, Babak Shafiei, Fereidoun Azizi, Asghar Ghasemi
Radioactive iodine therapy is commonly used as an adjuvant therapy in follicular and papillary thyroid carcinoma (PTC) and in the treatment of Graves' disease (GD). The basis of this therapy is the accumulation of radioactive iodine by the sodium-iodide symporter (NIS) in the thyroid gland. Expression of NIS by extrathyroidal tissues such as islets of pancreas has been reported. Radioactive iodine uptake by pancreatic beta-cells can potentially damage these cells. In this study, we discuss the possible associations between radioactive iodine and glucose intolerance...
July 2017: Cell Journal
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