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https://www.readbyqxmd.com/read/27875357/optimal-timing-of-endoscopic-retrograde-cholangiopancreatography-in-acute-cholangitis
#1
Linda A Hou, Loren Laine, Nima Motamedi, Ara Sahakian, Christianne Lane, James Buxbaum
OBJECTIVES: Acute cholangitis mandates resuscitation, antibiotic therapy, and biliary decompression. Our aim was to define the optimal timing of endoscopic retrograde cholangiopancreatography (ERCP) for patients with acute cholangitis. METHODS: Clinical data on all cases of cholangitis managed by ERCP were prospectively collected from September 2010 to July 2013. The clinical impact of the time to ERCP, defined as the time from presentation in the emergency department to the commencement of the ERCP, was determined...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27725645/histological-disease-activity-as-a-predictor-of-clinical-relapse-among-patients-with-ulcerative-colitis-systematic-review-and-meta-analysis
#2
Sunhee Park, Tsion Abdi, Mark Gentry, Loren Laine
OBJECTIVES: Endoscopic remission in ulcerative colitis (UC) is associated with improved clinical outcomes. We assessed whether histological remission predicts clinical outcomes, estimated the magnitude of effect, and determined whether histological remission provides additional prognostic utility beyond clinical or endoscopic remission. METHODS: Bibliographic databases were searched for studies in inflammatory bowel disease providing baseline histological status and relation to an outcome of clinical relapse or exacerbation...
October 11, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27624167/early-tips-in-u-s-patients-hospitalized-with-acute-esophageal-variceal-bleeding
#3
Basile Njei, Thomas R McCarty, Loren Laine
BACKGROUND AND AIM: Early transjugular intrahepatic portosystemic shunt (TIPS) used as preventive therapy prior to recurrent bleeding has been recommended in patients presenting with acute esophageal variceal bleeding (EVB) who are at high risk of further bleeding and death. We investigated the impact of early TIPS on outcomes of U.S. patients hospitalized with EVB from 2000 to 2010. METHODS: The Nationwide Inpatient Sample database was queried to identify patients with EVB and decompensated cirrhosis (because early TIPS is recommended only in high-risk patients)...
September 14, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27521511/risk-assessment-tools-for-gastrointestinal-bleeding
#4
Loren Laine
No abstract text is available yet for this article.
November 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27464591/no-benefit-from-platelet-transfusion-for-gastrointestinal-bleeding-in-patients-taking-antiplatelet-agents
#5
Liam Zakko, Tarun Rustagi, Maura Douglas, Loren Laine
BACKGROUND & AIMS: Antiplatelet agents decrease cardiovascular events but increase gastrointestinal bleeding (GIB). Guidelines propose platelet transfusion for patients who take antiplatelet agents and have serious GIB. We investigated whether such patients are at decreased risk for rebleeding or increased risk for cardiovascular events after platelet transfusion. METHODS: We performed a retrospective cohort study of patients with GIB admitted to Yale-New Haven Hospital from 2008 to 2013 who were taking antiplatelet agents and had platelet counts higher than 100 × 10(9)/L...
July 25, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27377519/randomized-trial-of-endoscopist-controlled-vs-assistant-controlled-wire-guided-cannulation-of-the-bile-duct
#6
James Buxbaum, Paul Leonor, Jonathan Tung, Christianne Lane, Ara Sahakian, Loren Laine
OBJECTIVES: Biliary cannulation is frequently the most difficult component of endoscopic retrograde cholangiopancreatography (ERCP). Techniques employed to improve safety and efficacy include wire-guided access and the use of sphincterotomes. However, a variety of options for these techniques are available and optimum strategies are not defined. We assessed whether the use of endoscopist- vs. assistant-controlled wire guidance and small vs. standard-diameter sphincterotomes improves safety and/or efficacy of bile duct cannulation...
July 5, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27305194/clinical-practice-upper-gastrointestinal-bleeding-due-to-a-peptic-ulcer
#7
REVIEW
Loren Laine
No abstract text is available yet for this article.
June 16, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27223636/diagnosis-of-sessile-serrated-adenomas-polyps-with-image-enhanced-endoscopy-a-systematic-review-and-meta-analysis
#8
Neil D Parikh, Louis Chaptini, Basile Njei, Loren Laine
BACKGROUND AND STUDY AIMS: Distinguishing sessile serrated adenomas/polyps (SSA/Ps) from non-neoplastic tissue may be challenging when white-light endoscopy (WLE) is used. Image-enhanced endoscopy (IEE) has shown accuracy in differentiating adenomas from hyperplastic polyps. The aim of this systematic review and meta-analysis was to evaluate the utility of IEE in diagnosis of SSA/Ps. METHODS: Studies were eligible if: they included patients undergoing colonoscopy with an endoscopy-based image-enhancement modality; endoscopic diagnoses, including SSA/P, were based on the appearance of polyps at IEE; and the corresponding histologic diagnoses of polyps were provided...
August 2016: Endoscopy
https://www.readbyqxmd.com/read/27215659/the-toronto-helicobacter-pylori-consensus-in-context
#9
EDITORIAL
David Y Graham, Loren Laine
No abstract text is available yet for this article.
July 2016: Gastroenterology
https://www.readbyqxmd.com/read/27207181/effect-of-intragastric-balloons-on-liver-enzymes-a-systematic-review-and-meta-analysis
#10
REVIEW
Violeta B Popov, Christopher C Thompson, Nitin Kumar, Maria M Ciarleglio, Yanhong Deng, Loren Laine
BACKGROUND: Intragastric balloons (IGBs) are safe and effective in inducing weight loss in obese patients. The objective of this study was to review and analyze the available data of the effect of IGB on markers of nonalcoholic fatty liver disease (NAFLD) and liver enzymes. METHODS: Searches were performed of MEDLINE and Embase databases from inception through January 2016. Study inclusion criteria were the following: ≥5 overweight or obese adult patients undergoing intragastric balloon placement, with liver tests [alanine aminotransferase (ALT) or gamma-glutamyl transpeptidase (GGT)] or markers of NAFLD (e...
September 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27205898/deflating-balloon-tamponade-should-we-expand-the-use-of-stents-for-severe-refractory-esophageal-variceal-bleeding
#11
EDITORIAL
Loren Laine
No abstract text is available yet for this article.
June 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27193565/pursuing-a-clinical-academic-career-during-gastroenterology-fellowship
#12
EDITORIAL
Sunhee Park, Loren Laine
No abstract text is available yet for this article.
August 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27158543/digital-chromoendoscopy-utilization-in-clinical-practice-a-survey-of-gastroenterologists-in-connecticut
#13
Karl M Langberg, Neil D Parikh, Yanhong Deng, Maria Ciarlegio, Loren Laine, Harry R Aslanian
AIM: To use a survey to characterize and identify potential barriers to the use of digital chromoendoscopy (DC) by practicing gastroenterologists. METHODS: An anonymous, internet-based survey was sent to gastroenterologists in Connecticut who were members of one of three national gastrointestinal organizations. The survey collected demographic information, frequency of DC use, types of procedures that the respondent performs, setting of practice (academic vs community), years out of training, amount of training in DC, desire to have DC training and perceived barriers to DC use...
May 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27143321/efficacy-and-safety-of-proton-pump-inhibitors-in-high-risk-cardiovascular-subsets-of-the-cogent-trial
#14
Muthiah Vaduganathan, Christopher P Cannon, Byron L Cryer, Yuyin Liu, Wen-Hua Hsieh, Gheorghe Doros, Marc Cohen, Angel Lanas, Thomas J Schnitzer, Thomas L Shook, Pablo Lapuerta, Mark A Goldsmith, Loren Laine, Deepak L Bhatt
BACKGROUND: Proton-pump inhibitors (PPIs) have been demonstrated to reduce rates of gastrointestinal events in patients requiring dual antiplatelet therapy (DAPT). Data are limited regarding the efficacy and safety of PPIs in high-risk cardiovascular subsets after acute coronary syndrome or percutaneous coronary intervention. METHODS: All patients enrolled in COGENT (Clopidogrel and the Optimization of Gastrointestinal Events Trial) were initiated on DAPT (with aspirin and clopidogrel) for various indications within the prior 21 days...
September 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27113114/long-term-ppi-use-balancing-potential-harms-and-documented-benefits
#15
Loren Laine, Anil Nagar
No abstract text is available yet for this article.
July 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27102531/improving-detection-of-colorectal-dysplasia-in-inflammatory-bowel-disease-surveillance
#16
EDITORIAL
Tonya Kaltenbach, Kenneth R McQuaid, Roy Soetikno, Loren Laine
No abstract text is available yet for this article.
May 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27082942/randomized-trial-of-1-week-versus-2-week-intervals-for-endoscopic-ligation-in-the-treatment-of-patients-with-esophageal-variceal-bleeding
#17
Sarah Sheibani, Saro Khemichian, John J Kim, Linda Hou, Arthur W Yan, James Buxbaum, Lily Dara, Loren Laine
UNLABELLED: The appropriate interval between ligation sessions for treatment of esophageal variceal bleeding is uncertain. The optimal interval would provide variceal eradication as rapidly as possible to lessen early rebleeding while minimizing ligation-induced adverse events. We randomly assigned patients hospitalized with acute esophageal variceal bleeding who had successful ligation at presentation to repeat ligation at 1-week or 2-week intervals. Beta-blocker therapy was also prescribed...
August 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27060426/high-quality-bowel-preparation-is-required-for-detection-of%C3%A2-sessile-serrated-polyps
#18
Brian T Clark, Loren Laine
BACKGROUND & AIMS: The effect of bowel preparation quality has been well-characterized for detection of adenomas but not for detection of sessile serrated adenomas/polyps (SSPs). We performed a prospective study to determine proportions of patients in whom SSPs were detected at different levels of bowel preparation quality, using common validated scoring systems. METHODS: Our study enrolled 749 male veterans 50-75 years old undergoing screening or surveillance colonoscopy...
August 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27012778/proton-pump-inhibitors-reduce-gastrointestinal-events-regardless-of-aspirin-dose-in-patients-requiring-dual-antiplatelet-therapy
#19
RANDOMIZED CONTROLLED TRIAL
Muthiah Vaduganathan, Deepak L Bhatt, Byron L Cryer, Yuyin Liu, Wen-Hua Hsieh, Gheorghe Doros, Marc Cohen, Angel Lanas, Thomas J Schnitzer, Thomas L Shook, Pablo Lapuerta, Mark A Goldsmith, Loren Laine, Christopher P Cannon
BACKGROUND: The COGENT (Clopidogrel and the Optimization of Gastrointestinal Events Trial) showed that proton-pump inhibitors (PPIs) safely reduced rates of gastrointestinal (GI) events in patients requiring dual antiplatelet therapy (DAPT). However, utilization of appropriate prophylactic PPI therapy remains suboptimal, especially with low-dose aspirin. OBJECTIVES: The authors investigated the safety and efficacy of PPI therapy in patients receiving DAPT in low- and high-dose aspirin subsets...
April 12, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/26866420/paradigm-shift-in-the-surveillance-and-management-of-dysplasia-in-inflammatory-bowel-disease-west
#20
REVIEW
Roy Soetikno, Tonya Kaltenbach, Kenneth R McQuaid, Venkataraman Subramanian, Rahul Kumar, Alan N Barkun, Loren Laine
Patients with long-standing inflammatory bowel disease (IBD) colitis have a 2.4-fold higher risk of developing colorectal cancer (CRC) than the general population, for both ulcerative colitis (UC) and Crohn's disease (CD) colitis. Surveillance colonoscopy is recommended to detect early CRC and dysplasia. Most dysplasia discovered in patients with IBD is actually visible. Recently published SCENIC (Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients: International Consensus Recommendations) consensus statements provide unifying recommendations for the optimal surveillance and management of dysplasia in IBD...
April 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
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