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https://www.readbyqxmd.com/read/29733829/presentation-of-the-julius-m-friedenwald-medal-to-loren-a-laine
#1
M Brian Fennerty
No abstract text is available yet for this article.
May 4, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29705263/previous-use-of-antithrombotic-agents-reduces-mortality-and-length-of-hospital-stay-in-patients-with-high-risk-upper-gastrointestinal-bleeding
#2
Philip D J Dunne, Stig B Laursen, Loren Laine, Harry R Dalton, Jing H Ngu, Michael Schultz, Adam Rahman, Andrea Anderloni, Iain A Murray, Adrian J Stanley
BACKGROUND & AIMS: Anti-thrombotic agents are risk factors for upper gastrointestinal bleeding (UGIB). However, few studies have evaluated their effects on patient outcomes. We assessed the effects of anti-thrombotic agents on outcomes of patients with high-risk UGIB. METHODS: We performed a prospective study of 619 patients with acute UGIB (defined by hematemesis, coffee-ground vomit or melena) who required intervention and underwent endoscopy at 8 centers in North America, Asia, and Europe, from March 2014 through March 2015...
April 26, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29475806/effects-of-gastroprotectant-drugs-for-the-prevention-and-treatment-of-peptic-ulcer-disease-and-its-complications-a-meta-analysis-of-randomised-trials
#3
Benjamin Scally, Jonathan R Emberson, Enti Spata, Christina Reith, Kelly Davies, Heather Halls, Lisa Holland, Kate Wilson, Neeraj Bhala, Christopher Hawkey, Marc Hochberg, Richard Hunt, Loren Laine, Angel Lanas, Carlo Patrono, Colin Baigent
BACKGROUND: Gastroprotectant drugs are used for the prevention and treatment of peptic ulcer disease and might reduce its associated complications, but reliable estimates of the effects of gastroprotectants in different clinical settings are scarce. We aimed to examine the effects of proton-pump inhibitors (PPIs), prostaglandin analogues, and histamine-2 receptor antagonists (H2RAs) in different clinical circumstances by doing meta-analyses of tabular data from all relevant unconfounded randomised trials of gastroprotectant drugs...
April 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29380820/severity-and-outcomes-of-upper-gastrointestinal-bleeding-with-bloody-vs-coffee-grounds-hematemesis
#4
Loren Laine, Stig B Laursen, Liam Zakko, Harry R Dalton, Jing H Ngu, Michael Schultz, Adrian J Stanley
OBJECTIVES: Numerous reviews indicate bloody hematemesis signifies more severe bleeding than coffee-grounds hematemesis. We assessed severity and outcomes related to bleeding symptoms in a prospective study. METHODS: Consecutive patients presenting with hematemesis or melena were categorized as bloody emesis (N=1209), coffee-grounds emesis without bloody emesis (N=701), or melena without hematemesis (N=1069). We assessed bleeding severity (pulse, blood pressure) and predictors of outcome (hemoglobin, risk stratification scores) at presentation, and outcomes of bleeding episodes...
March 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29368532/image-enhanced-endoscopy-is-specific-for-the-diagnosis-of-non-erosive-gastroesophageal-reflux-disease
#5
Neil D Parikh, Artur V Viana, Saloni Shah, Loren Laine
OBJECTIVES: We assessed the performance characteristics of image-enhanced endoscopy with i-Scan or narrow band imaging (NBI) in patients with non-erosive gastroesophageal reflux disease (GERD) compared to controls without heartburn. MATERIAL AND METHODS: Image-enhanced endoscopic findings of vascularity at the squamocolumnar junction, distal esophageal micro-erosions, and non-round pit pattern at the squamocolumnar junction were assessed in cases (heartburn not responsive to PPIs, positive results on validated GERD questionnaire, no esophageal erosions, esophageal biopsies with histologic evidence of GERD (basal cell hyperplasia, elongation of papillae and dilation of intercellular spaces all required)) and in controls (no GERD symptoms or esophageal erosions)...
January 25, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28906425/impact-of-changeover-to-newer-endoscopic-systems-on-quality-and-efficiency-of-screening-and-surveillance-colonoscopy-equipment-or-endoscopist
#6
Manpreet Singh, Melody Sacatos, Loren Laine
GOALS: The goal of this study is to assess whether changeover to newer endoscopic systems impacts quality or efficiency, and quantify the relation between increased withdrawal time and detection rates of sessile serrated polyps (SSPDR) and adenomas (ADR) in real-world practice. STUDY: Beginning 2 months after new endoscopic systems were implemented at 2 endoscopy units, we included all outpatients undergoing screening/surveillance colonoscopy for 4 months. Outpatients during the same 4-month period 1 year earlier comprised the control group...
September 12, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28866457/randomized-trial-of-cholangioscopy-guided-laser-lithotripsy-versus-conventional-therapy-for-large-bile-duct-stones-with-videos
#7
James Buxbaum, Ara Sahakian, Christopher Ko, Preeth Jayaram, Christianne Lane, Chung Yao Yu, Ravi Kankotia, Loren Laine
BACKGROUND AND AIMS: Bile duct stones >1 cm have a decreased incidence of successful endoscopic extraction and often require lithotripsy. Although previous guidelines suggested mechanical lithotripsy for large common bile duct stones, current guidelines suggest cholangioscopy-guided lithotripsy as an adjunct with or without balloon dilation or mechanical lithotripsy. However, no randomized trials have assessed the usefulness of this practice. METHODS: Patients with bile duct stones >1 cm in diameter were randomized in a 2:1 ratio to cholangioscopy-guided laser lithotripsy versus conventional therapy only...
April 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28841650/transparency-ethics-in-practice-revisiting-financial-conflicts-of-interest-disclosure-forms-in-clinical-practice-guidelines
#8
Yidan Lu, Derek J Jones, Nour Sharara, Tonya Kaltenbach, Loren Laine, Kenneth McQuaid, Roy Soetikno, Venkataraman Subramanian, Alan Barkun
BACKGROUND: Authors of clinical practice guidelines (CPGs) disclose financial conflicts of interest (FCOIs) to promote transparency ethics. Typically, they do so on standard declaration forms containing generic open-ended questions on FCOIs. Yet, the literature is scant on the format and effect of alternative disclosure forms. Does supplementing a standard form with subsequent detailed disclosure forms tailored to the context of the CPG improve the yield or accuracy of FCOIs declarations? METHODS: For an international CPG in gastroenterology on the endoscopic surveillance for colorectal neoplasia in inflammatory bowel disease, we compared the use of a standard FCOIs disclosure form with a contextual FCOIs disclosure form that detailed commercial relations related to the CPG topic...
2017: PloS One
https://www.readbyqxmd.com/read/28818507/optimizing-the-quality-of-endoscopy-in-inflammatory-bowel-disease-focus-on-surveillance-and-management-of-colorectal-dysplasia-using-interactive-image-and-video-based-teaching
#9
Tonya R Kaltenbach, Roy M Soetikno, Rebecca DeVivo, Loren A Laine, Alan Barkun, Kenneth R McQuaid
BACKGROUND AND AIMS: Varying recommendations regarding the detection and management of dysplasia can lead to uncertainty and may impede the uptake of strategies that could improve surveillance in patients with inflammatory bowel disease (IBD). An educational event was held to assist in disseminating the recently published Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients: International Consensus Recommendations (SCENIC). METHODS: Specialists in IBD and endoscopy led the Optimizing Quality of Endoscopy in IBD course...
December 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28728669/is-there-a-role-for-combined-sclerotherapy-and-ligation-in-the-endoscopic-treatment-of-gastroesophageal-varices
#10
EDITORIAL
Loren Laine
No abstract text is available yet for this article.
August 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28666949/bleeding-with-direct-oral-anticoagulants-the-gastrointestinal-tract-and-beyond
#11
EDITORIAL
Loren Laine
No abstract text is available yet for this article.
November 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28657377/predictors-and-outcomes-of-delayed-plastic-biliary-stent-removal-following-endoscopic-retrograde-cholangiopancreatography
#12
Shawn J Kim, Edmond Ohanian, Frances Lee, Bryan Nam, Kendrick Che, Loren Laine, Sarah E Kim, John J Kim
OBJECTIVE: Plastic biliary stents are commonly placed during endoscopic retrograde cholangiopancreatography (ERCP) and should be removed or replaced within 3 months to reduce the risk of stent obstruction. The aim of the study was to identify predictors and outcomes of patients who had delayed plastic biliary stent removal following ERCP. MATERIALS AND METHODS: Consecutive patients who received ERCP with plastic biliary stent placement at Loma Linda University Medical Center (10/2004-6/2013) were identified...
October 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28528939/aga-white-paper-training-and-implementation-of-endoscopic-image-enhancement-technologies
#13
Neil Gupta, Joel V Brill, Marcia Canto, Daniel DeMarco, Brian M Fennerty, Loren Laine, David Lieberman, Charles Lightdale, Elizabeth Montgomery, Robert Odze, Douglas Rex, Prateek Sharma, Jeffrey L Tokar, Michael L Kochman
Endoscopic image-enhancement technologies provide opportunities to visualize normal and abnormal tissues within the gastrointestinal (GI) tract in a manner that complements conventional white light endoscopic imaging. The additional information that is obtained enables the endoscopist to better identify, delineate, and characterize lesions and can facilitate targeted biopsies or, in some cases, eliminate the need to send samples for histologic analysis. Some of these technologies have been available for more than a decade, but despite this fact, there is limited use of these technologies by endoscopists...
June 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28396275/relationship-of-time-to-presentation-after-onset-of-upper-gi-bleeding-with-patient-characteristics-and-outcomes-a-prospective-study
#14
Loren Laine, Stig B Laursen, Harry R Dalton, Jing H Ngu, Michael Schultz, Adrian J Stanley
BACKGROUND AND AIMS: We performed a prospective multi-national study of patients presenting to the emergency department with upper GI bleeding (UGIB) and assessed the relationship of time to presentation after onset of UGIB symptoms with patient characteristics and outcomes. METHODS: Consecutive patients presenting with overt UGIB (red-blood emesis, coffee-ground emesis, and/or melena) from March 2014 to March 2015 at 6 hospitals were included. Multiple predefined patient characteristics and outcomes were collected...
December 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28366441/narrow-band-imaging-versus-white-light-versus-mapping-biopsy-for-gastric-intestinal-metaplasia-a-prospective-blinded-trial
#15
James L Buxbaum, David Hormozdi, Mario Dinis-Ribeiro, Christianne Lane, Diogo Dias-Silva, Ara Sahakian, Preeth Jayaram, Pedro Pimentel-Nunes, Daniel Shue, Michael Pepper, Daniel Cho, Loren Laine
BACKGROUND AND AIMS: Gastric intestinal metaplasia (GIM) is a gastric cancer precursor. Narrow-band imaging (NBI) may improve detection of GIM. We compared detection of GIM with high-definition white-light (HD-WL) endoscopy, NBI, and mapping biopsies in a population with increased gastric cancer risk. METHODS: Patients undergoing upper endoscopy had HD-WL examination by 1 endoscopist, followed by an NBI examination by a second endoscopist blinded to HD-WL findings...
November 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28266591/early-aggressive-hydration-hastens-clinical-improvement-in-mild-acute-pancreatitis
#16
RANDOMIZED CONTROLLED TRIAL
James L Buxbaum, Michael Quezada, Ben Da, Niraj Jani, Christianne Lane, Didi Mwengela, Thomas Kelly, Paul Jhun, Kiran Dhanireddy, Loren Laine
OBJECTIVES: Early aggressive intravenous hydration is recommended for acute pancreatitis treatment although randomized trials have not documented benefit. We performed a randomized trial of aggressive vs. standard hydration in the initial management of mild acute pancreatitis. METHODS: Sixty patients with acute pancreatitis without systemic inflammatory response syndrome (SIRS) or organ failure were randomized within 4 h of diagnosis to aggressive (20 ml/kg bolus followed by 3 ml/kg/h) vs...
May 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28174126/accuracy-of-asge-high-risk-criteria-in-evaluation-of-patients-with-suspected-common-bile-duct-stones
#17
Huiqin He, Chenfei Tan, Jiaguo Wu, Ning Dai, Weiling Hu, Yawen Zhang, Loren Laine, James Scheiman, John J Kim
BACKGROUND AND AIMS: ERCP is recommended for patients considered high risk for choledocholithiasis after biochemical testing and abdominal US. Our aim was to determine whether the American Society for Gastrointestinal Endoscopy (ASGE) guidelines accurately select patients for whom the risk of ERCP is justified. METHODS: Consecutive patients hospitalized with suspected choledocholithiasis at Sir Run Run Shaw Hospital who received biochemical testing, abdominal US, and definitive testing for choledocholithiasis (MRCP, EUS, ERCP, intraoperative cholangiogram, and/or common bile duct [CBD] exploration) were identified...
September 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28159539/continued-midazolam-versus-diphenhydramine-in-difficult-to-sedate-patients-a-randomized-double-blind-trial
#18
Hamita Sachar, Nipaporn Pichetshote, Kavitha Nandigam, Keta Vaidya, Loren Laine
BACKGROUND AND AIMS: Current guidelines recommend diphenhydramine in patients undergoing endoscopy who are not adequately sedated with a benzodiazepine and opioid combination. Because this practice has not been adequately assessed, we performed a randomized, double-blind trial comparing diphenhydramine with continued midazolam in such patients. METHODS: Patients undergoing elective colonoscopy with moderate sedation were eligible. Sedation was measured with the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score with adequate sedation defined as 3 on a 0- to 5-point scale...
May 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28143773/the-aga-s-fecal-microbiota-transplantation-national-registry-an-important-step-toward-understanding-risks-and-benefits-of-microbiota-therapeutics
#19
EDITORIAL
Colleen R Kelly, Alison M Kim, Loren Laine, Gary D Wu
No abstract text is available yet for this article.
March 2017: Gastroenterology
https://www.readbyqxmd.com/read/28053181/comparison-of-risk-scoring-systems-for-patients-presenting-with-upper-gastrointestinal-bleeding-international-multicentre-prospective-study
#20
MULTICENTER STUDY
Adrian J Stanley, Loren Laine, Harry R Dalton, Jing H Ngu, Michael Schultz, Roseta Abazi, Liam Zakko, Susan Thornton, Kelly Wilkinson, Cristopher J L Khor, Iain A Murray, Stig B Laursen
OBJECTIVE:  To compare the predictive accuracy and clinical utility of five risk scoring systems in the assessment of patients with upper gastrointestinal bleeding. DESIGN:  International multicentre prospective study. SETTING:  Six large hospitals in Europe, North America, Asia, and Oceania. PARTICIPANTS:  3012 consecutive patients presenting over 12 months with upper gastrointestinal bleeding. MAIN OUTCOME MEASURES:  Comparison of pre-endoscopy scores (admission Rockall, AIMS65, and Glasgow Blatchford) and post-endoscopy scores (full Rockall and PNED) for their ability to predict predefined clinical endpoints: a composite endpoint (transfusion, endoscopic treatment, interventional radiology, surgery, or 30 day mortality), endoscopic treatment, 30 day mortality, rebleeding, and length of hospital stay...
January 4, 2017: BMJ: British Medical Journal
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