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https://www.readbyqxmd.com/read/28802550/mr-coagulation-a-novel-minimally-invasive-approach-to-aneurysm-repair
#1
Ouri Cohen, Ming Zhao, Erez Nevo, Jerome L Ackerman
PURPOSE: To demonstrate a proof of concept of magnetic resonance (MR) coagulation, in which MR imaging scanner-induced radiofrequency (RF) heating at the end of an intracatheter long wire heats and coagulates a protein solution to effect a vascular repair by embolization. MATERIALS AND METHODS: MR coagulation was simulated by finite-element modeling of electromagnetic fields and specific absorption rate (SAR) in a phantom. A glass phantom consisting of a spherical cavity joined to the side of a tube was incorporated into a flow system to simulate an aneurysm and flowing blood with velocities of 0-1...
August 9, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28777263/a-stepped-wedge-cluster-randomized-controlled-trial-to-promote-option-b-retention-in-central-mozambique
#2
James T Pfeiffer, Manuel Napúa, Bradley H Wagenaar, Falume Chale, Roxanne Hoek, Mark Micek, Joao Manuel, Cathy Michel, Jessica Greenberg Cowan, James F Cowan, Sarah Gimbel, Kenneth Sherr, Stephen Gloyd, Rachel R Chapman
BACKGROUND: This randomized trial studied performance of Option B+ in Mozambique, and evaluated an enhanced retention package in public clinics. SETTING: The study was conducted at 6 clinics in Manica and Sofala Provinces in central Mozambique. METHODS: 761 pregnant women tested HIV+, immediately initiated ART, and were followed to track retention at 6 clinics from May 2014 - May 2015. Clinics were randomly allocated within a stepped-wedge fashion to intervention and control periods...
July 31, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28776084/the-association-of-depressive-symptoms-and-diabetes-distress-with-glycaemic-control-and-diabetes-complications-over-2%C3%A2-years-in-newly-diagnosed-type-2-diabetes-a-prospective-cohort-study
#3
Khalida Ismail, Calum D Moulton, Kirsty Winkley, John C Pickup, Stephen M Thomas, Roy A Sherwood, Daniel Stahl, Stephanie A Amiel
AIMS/HYPOTHESIS: We examined the associations between depressive symptoms and diabetes distress with glycaemic control and diabetes complications over 2 years, after diagnosis of type 2 diabetes. METHODS: In a multi-ethnic, primary care cohort (n = 1735) of adults, all with recent (<6 months) diagnosis of type 2 diabetes, we measured the associations between depressive symptoms (Patient Health Questionnaire-9 [PHQ-9] score ≥10) and diabetes distress (Problem Areas in Diabetes [PAID] score ≥40), with change in 2 year HbA1c as the primary outcome and with incident rates of diabetes complications as secondary outcomes...
August 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/28775207/development-of-aggressive-pancreatic-ductal-adenocarcinomas-depends-on-granulocyte-colony-stimulating-factor-secretion-in-carcinoma-cells
#4
Michael W Pickup, Philip Owens, Agnieszka E Gorska, Anna Chytil, Fei Ye, Chanjuan Shi, Valerie M Weaver, Raghu Kalluri, Harold L Moses, Sergey V Novitskiy
The survival rate for pancreatic ductal adenocarcinoma (PDAC) remains low. More therapeutic options to treat this disease are needed, for the current standard of care is ineffective. Using an animal model of aggressive PDAC (Kras/p48(TGFβRIIKO)), we discovered an effect of TGFβ signaling in regulation of G-CSF secretion in pancreatic epithelium. Elevated concentrations of G-CSF in PDAC promoted differentiation of Ly6G(+) cells from progenitors, stimulated IL10 secretion from myeloid cells, and decreased T-cell proliferation via upregulation of Arg, iNOS, VEGF, IL6, IL1b from CD11b(+) cells...
August 3, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28774975/genome-sequence-of-human-papillomavirus-type-20-strain-hpv-20-lancaster-2015
#5
Kate V Atkinson, Lisa A Bishop, Glenn Rhodes, Nicolas Salez, Neil R McEwan, Matthew J Hegarty, Julie Robey, Nicola Harding, Simon Wetherell, Robert M Lauder, Roger W Pickup, Mark Wilkinson, Derek Gatherer
The genome sequence of human papillomavirus type 20 (HPV-20; family Papillomaviridae, genus Betapapillomavirus, species Betapapillomavirus 1, type 20) was assembled by deep sequencing from nasopharyngeal swabs. The assembled genome is 0.37% divergent over its full length from the single complete genome of HPV-20 in GenBank (U31778). We named the strain HPV-20/Lancaster/2015.
August 3, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28755536/using-fixed-parameter-and-random-parameter-ordered-regression-models-to-identify-significant-factors-that-affect-the-severity-of-drivers-injuries-in-vehicle-train-collisions
#6
Essam Dabbour, Said Easa, Murtaza Haider
This study attempts to identify significant factors that affect the severity of drivers' injuries when colliding with trains at railroad-grade crossings by analyzing the individual-specific heterogeneity related to those factors over a period of 15 years. Both fixed-parameter and random-parameter ordered regression models were used to analyze records of all vehicle-train collisions that occurred in the United States from January 1, 2001 to December 31, 2015. For fixed-parameter ordered models, both probit and negative log-log link functions were used...
July 26, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28750299/prolonged-activation-of-the-coagulation-system-during-in-vitro-fertilization-cycles
#7
Yoni Cohen, Togas Tulandi, Benny Almog, Eyal Zohav, Varda Deutsch, Ariel Many, Ami Amit, Aviad Cohen
OBJECTIVE: To investigate coagulation system changes during an in-vitro fertilization (IVF) cycle using Thromboelastogram (TEG) that enables analysis of the elastic properties of whole blood samples and provides a global assessment of the hemostatic function. STUDY DESIGN: A prospective study. TEG indices were evaluated in 23 women who underwent controlled ovarian stimulation for IVF at four points in time: 1. At the beginning of the cycle (corresponding to the lowest levels of E2), 2...
July 17, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28744919/differential-expression-of-insulin-like-growth-factor-family-members-in-immature-cumulus-oocyte-complexes-from-dairy-cows-with-different-genotypes
#8
A C Lopes, M P Palhão, Cac Fernandes, M J Sudano, Acs Castilho, E S Caixeta
It has been evident the improvement of in vitro embryo production (IVEP) in dairy cows. Nevertheless, it is known that differences in the number and quality of oocytes between taurine and zebu females impact the efficiency and economic viability of IVEP. As the insulin-like growth factor (IGF) system is related to follicular and oocyte development, we aimed to quantify mRNA abundance of IGF system members and pregnancy-associated plasma protein-A (PAPPA) in the cumulus-oocyte complexes (COCs) of Gir, 1/2 Holstein × 1/2 Gir and Holstein cows...
July 25, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28744698/association-of-basal-serum-androgen-levels-with-ovarian-response-and-icsi-cycle-outcome
#9
C Abide Yayla, E Ozkaya, S Kayatas Eser, I Sanverdi, B Devranoglu, T Kutlu
BACKGROUND: The purpose of this study was to assess the predictive value of basal serum testosterone (T) and dehydroepiandrosterone sulfate (DHEAS) levels during follicular phase for ovarian response and outcome in intracytoplasmic sperm injection (ICSI) cycles of women with diminished ovarian reserve. METHODS: We prospectively gathered data of basal serum androgen levels and ICSI cycle characteristics of 120 women with diminished ovarian reserve. Association of basal serum T and DHEAS levels with ovarian response was analyzed...
July 25, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28735836/importance-of-deformable-image-registration-and-biological-dose-summation-in-planning-of-radiotherapy-retreatments
#10
Eeva Boman, Mika Kapanen, Lyndsey Pickup, Sirpa-Liisa Lahtela
The purpose of this study is to evaluate the effect of nonrigid and fractionation-corrected dose summation on total doses in radiotherapy and to demonstrate the benefits of such dose summation on clinical decision-making for planning of retreatments. Dose summation of organs at risk (OARs) was investigated for 3 clinical cases with need of retreatment to the same site: head and neck, brain, and mediastinum. Three different summation methods over old and new radiotherapy treatment plans are presented and compared: (1) rigid raw sum with rigid registration of the planning images and direct dose summing; (2) deformable raw sum with deformable image registration and direct dose summing; and (3) deformable biological sum with deformable registration and takes into account the dose per fraction in biological manner in certain critical organs...
July 20, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28712801/the-effect-of-pelvic-tilt-and-femoral-head-size-on-hip-range-of-motion-to-impingement
#11
Thomas F McCarthy, Jim Nevelos, Randa K Elmallah, Morad Chughtai, Anton Khlopas, Vincent Alipit, Timothy C Wagner, Michael A Mont
BACKGROUND: About 50%-70% of dislocators have cups placed within so-called "safe zones." It has been postulated that factors such as femoral head size and pelvic tilt, obliquity, or rotation may influence postoperative stability. Therefore, we assessed varying degrees of pelvic tilt and head sizes on the range of motion (ROM) to impingement. METHODS: A hip simulator was used to import models of 10 subjects who performed object pickup, squatting, and low-chair rising...
June 15, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28657971/laryngeal-mask-airway-as-a-rescue-device-for-failed-endotracheal-intubation-during-scene-to-hospital-air-transport-of-combat-casualties
#12
Itai Shavit, Eliad Aviram, Yoav Hoffmann, Oded Biton, Elon Glassberg
BACKGROUND: Advanced airway management of combat casualties during scene-to-hospital air transport is challenging. Because of the short transport time, flight physicians of the Israeli military airborne combat evacuation unit are approved for the use of a laryngeal mask airway (LMA) in the event of failed endotracheal intubation (ETI). The aim of this study was to assess the effectiveness of LMA use during scene-to-hospital transport of combat casualties in Israel. PATIENTS AND METHODS: A retrospective cohort analysis of all combat casualties treated with ETI during scene-to-hospital transport over a 3-year period was carried out...
June 27, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28638948/does-socioeconomic-status-influence-the-epidemiology-and-outcome-of-distal-radial-fractures-in-adults
#13
N D Clement, A D Duckworth, N R Wickramasinghe, C M Court-Brown, M M McQueen
PURPOSE: The aim of this study in adult patients with a distal radial fracture was to determine whether socioeconomic status influenced the epidemiology, mechanism of injury, fracture severity, or the outcome according to function, radiographic assessment, and rate of associated complications. METHODS: We identified 3983 distal radial fractures over a 7-year period. Socioeconomic status was assigned using the Carstairs score, and the population was divided into quintiles depending on deprivation...
June 21, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28625667/dynamics-of-pvy-strains-in-field-grown-potato-impact-of-strain-competition-and-ability-to-overcome-host-resistance-mechanisms
#14
Kim Davie, Ross Holmes, Jon Pickup, Christophe Lacomme
Potato virus Y (PVY) is the most important viral pathogen affecting potato crops worldwide. PVY can be transmitted non-persistently by aphids that do not colonize the host plant, resulting in a rapid acquisition and transmission of the virus between plants. PVY exists as a complex of strains that can be distinguished according to their pathogenicity, serology and genomic analysis. While virus incidence remains low in Scottish seed potato crops, PVY has become the increasingly prevalent virus. The monitoring of PVY(N) and PVYO serotypes has revealed a recent shift towards PVY(N) which now accounts for more than 90% of all PVY cases...
June 16, 2017: Virus Research
https://www.readbyqxmd.com/read/28622940/feasibility-of-performing-non-contrast-magnetic-resonance-angiography-in-pregnant-subjects-with-familial-aortopathies
#15
William E Moody, Luke Pickup, Emma Plunkett, John Fryearson, Paul F Clift, R Katie Morris, Peter J Thompson, Sara Thorne, Lucy E Hudsmith
BACKGROUND: Pregnancy is associated with an increased risk of aortic pathology. We sought to assess the feasibility of performing non-contrast 3D steady-state free-precession (SSFP) magnetic resonance angiography (MRA) in pregnant subjects with inherited aortopathy. METHODS: Fifteen pregnant subjects (age 27±4yr) with positive genotyping for aortopathy (Marfan, Loeys-Dietz, Ehlers-Danlos) and/or a family history of aortic dissection underwent non-contrast 3D-SSFP MRA at 1...
June 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28622784/first-trimester-inter-and-intrafetal-size-discrepancies-in-bichorionic-twins-conceived-by-in%C3%A2-vitro-fertilization-can-it-predict-pregnancy-outcome
#16
Ron Bardin, Galia Oron, Yael Levy, Onit Sapir, Israel Meizner, Benjamin Fisch, Arnon Wiznitzer, Eran Hadar
OBJECTIVE: To evaluate the association between first-trimester inter- and intrafetal size discrepancies and pregnancy outcome, among bichorionic-biamniotic twins conceived by IVF. DESIGN: A retrospective study design was used. SETTING: Tertiary university-affiliated medical center. PATIENT(S): All women with a viable first-trimester bichorionic-biamniotic twin gestation, who conceived after IVF in 2007-2015. INTERVENTION(S): None...
June 13, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28620485/variation-in-activity-levels-amongst-dogs-of-different-breeds-results-of-a-large-online-survey-of-dog-owners-from-the-uk
#17
Emily Pickup, Alexander J German, Emily Blackwell, Mark Evans, Carri Westgarth
Regular physical activity is an important means of promoting health, both in people and their pets. Walking is the most common method used for dogs, but there is a lack of clarity on how much daily activity different breeds of dog require. Data from an online survey of UK dog owners were collected between June and August in 2014. The University of Liverpool Ethics Committee approved the project, and owners consented to data use. The initial dataset (17 028 dogs) was first cleaned to remove erroneous data, and then edited to remove mixed breed dogs, leaving a total of 12 314 dogs from known pedigree breeds...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28587137/modelling-and-optimization-of-four-segment-shielding-coils-of-current-transformers
#18
Yucheng Gao, Wei Zhao, Qing Wang, Kaifeng Qu, He Li, Haiming Shao, Songling Huang
Applying shielding coils is a practical way to protect current transformers (CTs) for large-capacity generators from the intensive magnetic interference produced by adjacent bus-bars. The aim of this study is to build a simple analytical model for the shielding coils, from which the optimization of the shielding coils can be calculated effectively. Based on an existing stray flux model, a new analytical model for the leakage flux of partial coils is presented, and finite element method-based simulations are carried out to develop empirical equations for the core-pickup factors of the models...
May 26, 2017: Sensors
https://www.readbyqxmd.com/read/28584610/the-usefulness-of-nap-sleep-recording-during-routine-electroencephalography-an-audit-study
#19
Sami Farah Al-Rawas, Khidir M Abdelbasit, Huda Hussain Al-Lawati, Rajesh Poothrikovil, Amal Khalfan Al-Rawahi, Abdul Aleem Khan, Robert Shane Delamont
OBJECTIVES: A measure to increase the electroencephalogram (EEG) outcome includes a short period of nap sleep during a routine standard EEG with the aim of increasing its sensitivity to interictal abnormalities or provoking seizures. As part of an ongoing auditing of our EEG data, we aimed to investigate the contribution of nap sleep during routine outpatient department based EEGs requested for a variety of reasons. METHODS: EEG data at the Department of Clinical Physiology at Sultan Qaboos University Hospital, Oman, from July 2006 to December 2007 and from January 2009 to December 2010 (total 42 months) were reviewed...
May 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28550146/does-painless-rectal-bleeding-equate-to-a-colonic-polyp
#20
Alison Morag Campbell, Ian Sugarman
BACKGROUND: It is often stated that if a patient presents with 'painless rectal bleeding' then a rectal polyp is the probable diagnosis. The aim of this study is to review our experience of children undergoing endoscopy to assess if the above statement is correct. METHODS: The senior author keeps a prospective database of every child undergoing flexible sigmoidoscopy or colonoscopy. As part of this database, the symptoms and signs that the patient presents with, specifically abdominal pain, diarrhoea, mucous per rectum and rectal bleeding, are recorded...
May 26, 2017: Archives of Disease in Childhood
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