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Margaretha Gansterer, Richard F Hartl, Philipp E H Salzmann
In this study we investigate the decision problem of a central authority in pickup and delivery carrier collaborations. Customer requests are to be redistributed among participants, such that the total cost is minimized. We formulate the problem as multi-depot traveling salesman problem with pickups and deliveries. We apply three well-established exact solution approaches and compare their performance in terms of computational time. To avoid unrealistic solutions with unevenly distributed workload, we extend the problem by introducing minimum workload constraints...
2018: Central European Journal of Operations Research
Katarína Boďová, Tadeas Priklopil, David L Field, Nicholas H Barton, Melinda Pickup
Self-incompatibility (SI) is a genetically based recognition system that functions to prevent self-fertilization and mating among related plants. An enduring puzzle in SI is how the high diversity observed in nature arises and is maintained. Based on the underlying recognition mechanism, SI can be classified into two main groups: self- and non-self recognition. Most work has focused on diversification within self-recognition systems despite expected differences between the two groups in the evolutionary pathways and outcomes of diversification...
April 30, 2018: Genetics
P Thieberger, D Gassner, R Hulsart, R Michnoff, T Miller, M Minty, Z Sorrell, A Bartnik
A simple, analytically correct algorithm is developed for calculating "pencil" relativistic beam coordinates using the signals from an ideal cylindrical particle beam position monitor (BPM) with four pickup electrodes (PUEs) of infinitesimal widths. The algorithm is then applied to simulations of realistic BPMs with finite width PUEs. Surprisingly small deviations are found. Simple empirically determined correction terms reduce the deviations even further. The algorithm is then tested with simulations for non-relativistic beams...
April 2018: Review of Scientific Instruments
Kwaku F Boakye, Asad Khattak, Jerry Everett, Shashi Nambisan
When properly worn, seatbelts can save lives. They are designed to prevent occupants from hitting objects inside their vehicle and from being ejected out of their vehicle in the event of a crash. Despite their proven effectiveness in reducing the severity of injuries, seatbelt non-use among passengers still remains a problem, especially at night. Although the factors associated with not using a seatbelt have been widely studied, research studies documenting this behavior at night are limited in the literature...
April 18, 2018: Accident; Analysis and Prevention
A Pysanenko, J Lengyel, M Fárník
The uptake of atmospheric oxidized organics on acid clusters is relevant for atmospheric new particle formation. We investigate the pickup of methanol (CH3 OH) on mixed nitric acid-water clusters (HNO3 )M (H2 O)N by a combination of mass spectrometry and cluster velocity measurements in a molecular beam. The mass spectra of the mixed clusters exhibit (HNO3 )m (H2 O)n H+ series with m = 0-3 and n = 0-12. In addition, CH3 OH·(HNO3 )m (H2 O)n H+ series with very similar patterns appear in the spectra after the methanol pickup...
April 21, 2018: Journal of Chemical Physics
Tony Lower, John Temperley
ISSUES ADDRESSED: Agriculture is recognised as a highly dangerous sector worldwide, hence the use of evidence-based solutions to address injury related incidents are critical to prevention. The main of this paper is to determine the potential for prevention by use of existing controls based on deaths data from 2001-2016. METHODS: This study assesses data from the National Coroner's Information System for the period 2001-2016 in regards to unintentional farm injury deaths in Australia (n = 1,271)...
April 18, 2018: Health Promotion Journal of Australia
Ilfita Sahbudin, Luke Pickup, Peter Nightingale, Gina Allen, Zaeem Cader, Ruchir Singh, Paola de Pablo, Christopher D Buckley, Karim Raza, Andrew Filer
Objectives: Tenosynovitis (TS) is common in early arthritis. However, the value of US-defined TS in predicting RA development is unclear. We assessed the predictive utility of US-defined TS alongside US-defined synovitis and clinical and serological variables in a prospective cohort of early arthritis patients. Methods: One hundred and seven patients with clinically apparent synovitis of one or more joint and symptom duration ⩽3 months underwent baseline clinical, laboratory and US assessment of 19 bilateral joint sites and 16 bilateral tendon compartments...
April 3, 2018: Rheumatology
Kimberly Vachal
Motor vehicle crashes are a leading cause of death for youth. Appropriate occupant protection significantly reduces these preventable injuries. Secondary field observation survey records were studied to identify populations that would most likely benefit from youth occupant protection programs. Multivariate regression analysis showed that drivers of youth between 4 and 14 years were in need of programs promoting youth and driver occupant restraint use. When these drivers were using seat belts, it was 35 times more likely they had youth occupants in safety restraints...
April 4, 2018: International Journal of Injury Control and Safety Promotion
Amy L Cochran, Beth A Tarini, Mary Kleyn, Gabriel Zayas-Cabán
Objectives This study aimed to determine which steps in the newborn screening collection and delivery processes contribute to delays and identify strategies to improve timeliness. Methods Data was analyzed from infants (N = 94,770) who underwent newborn screening at 83 hospitals in Michigan between April 2014 and March 2015. Linear mixed effects models estimated effects of hospital and newborn characteristics on times between steps in the process, whereas simulation explored how to improve timeliness through adjustments to schedules for the state laboratory and for specimen pickup from hospitals...
April 3, 2018: Maternal and Child Health Journal
S Padin
An off-axis three-mirror anastigmat is proposed for future cosmic microwave background observations. The telescope has a 5 m diameter primary, giving 1.5' angular resolution at λ=2  mm, which is sufficient for measurements of gravitational lensing and for galaxy cluster surveys. The design includes several key features, not previously combined in a large telescope, that are important for sensitive measurements, especially on large angular scales: (1) high throughput (8° diameter diffraction-limited field of view at λ=1  mm, and 12×8° at λ=3  mm, so a single telescope could support all the detectors for an optimistic, future experiment); (2) low scattering (all the mirrors are small enough to be monolithic, so there are no segment gaps); (3) full boresight rotation, over the full elevation range, for measuring polarization errors; and (4) a comoving shield or baffle around the entire telescope to control pickup...
March 20, 2018: Applied Optics
Lorena Lobo, David Travieso, David M Jacobs, Matthew Rodger, Cathy M Craig
This study investigates how active exploration helps users of sensory substitution devices (SSDs) to detect action-relevant information. A vibrotactile SSD was developed that generates stimulation that is contingent on the users' movements. Target direction was specified by the location of the vibratory stimulation, and target distance by the size and intensity of the pattern of stimulation. A series of experiments was performed with blindfolded participants. In Experiments 1a to 1c, participants used the SSD to align their central body axis with prespecified targets...
March 2018: Journal of Experimental Psychology. Applied
Daniel H Adler, Laura E M Wisse, Ranjit Ittyerah, John B Pluta, Song-Lin Ding, Long Xie, Jiancong Wang, Salmon Kadivar, John L Robinson, Theresa Schuck, John Q Trojanowski, Murray Grossman, John A Detre, Mark A Elliott, Jon B Toledo, Weixia Liu, Stephen Pickup, Michael I Miller, Sandhitsu R Das, David A Wolk, Paul A Yushkevich
Although the hippocampus is one of the most studied structures in the human brain, limited quantitative data exist on its 3D organization, anatomical variability, and effects of disease on its subregions. Histological studies provide restricted reference information due to their 2D nature. In this paper, high-resolution (∼200 × 200 × 200 μm3 ) ex vivo MRI scans of 31 human hippocampal specimens are combined using a groupwise diffeomorphic registration approach into a 3D probabilistic atlas that captures average anatomy and anatomic variability of hippocampal subfields...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
A Talwar, J M Y Willaime, L C Pickup, M Enescu, D Boukerroui, W Hickes, N M Rahman, M J Gooding, T Kadir, F V Gleeson
INTRODUCTION: Although nodule volumetry is a recognized biomarker of malignancy in pulmonary nodules (PNs), caution is needed in its interpretation because of variables such as respiratory volume variation and inter-scan variability of up to 25%. CT Texture Analysis (CTTA) is a potential independent biomarker of malignancy but inter-scan variability and respiratory volume variation has not been assessed. METHODS: In this prospective cohort study, 40 patients (20 with an indeterminate PN and 20 with pulmonary metastases) underwent two LDCTs within a 60-min period (the "Coffee-break") with the aim of assessing the repeatability of CTTA and semi-automated volume measurements...
April 2018: European Journal of Radiology
Wudan Yan
In early September 2017, when the rains from Hurricane Harvey finally subsided in Houston, Texas, Seth Pedersen loaded up his pickup truck with sample collection kits, waders, rubber boots, buckets, and a small aluminum fishing boat. On that particular day, Pedersen, a second-year graduate student in environmental engineering at Rice University, was-along with a fellow graduate student-on a mission to test the water in homes flooded by Hurricane Harvey. He was looking specifically for E. coli bacteria, chemicals, heavy metals, and other pathogens (Figure 1)...
March 2018: IEEE Pulse
S S Rushley, D Kim, C S Bretherton, M-S Ahn
Bretherton et al. (2004) used the Special Sensor Microwave Imager (SSM/I) version 5 product to derive an exponential curve that describes the relationship between precipitation and column relative humidity (CRH) over the tropical oceans. The curve, which features a precipitation pickup at a CRH of about 0.75 and a rapid increase of precipitation with CRH after the pickup, has been widely used in the studies of the tropical atmosphere. This study re-examines the moisture-precipitation relationship by using the version 7 SSM/I data, in which several biases in the previous version are corrected, and evaluates the relationship in the Coupled Model Intercomparison Project phase 5 (CMIP5) models...
January 28, 2018: Geophysical Research Letters
Urmimala Maitra, Robert A House, James W Somerville, Nuria Tapia-Ruiz, Juan G Lozano, Niccoló Guerrini, Rong Hao, Kun Luo, Liyu Jin, Miguel A Pérez-Osorio, Felix Massel, David M Pickup, Silvia Ramos, Xingye Lu, Daniel E McNally, Alan V Chadwick, Feliciano Giustino, Thorsten Schmitt, Laurent C Duda, Matthew R Roberts, Peter G Bruce
The search for improved energy-storage materials has revealed Li- and Na-rich intercalation compounds as promising high-capacity cathodes. They exhibit capacities in excess of what would be expected from alkali-ion removal/reinsertion and charge compensation by transition-metal (TM) ions. The additional capacity is provided through charge compensation by oxygen redox chemistry and some oxygen loss. It has been reported previously that oxygen redox occurs in O 2p orbitals that interact with alkali ions in the TM and alkali-ion layers (that is, oxygen redox occurs in compounds containing Li+ -O(2p)-Li+ interactions)...
March 2018: Nature Chemistry
Ronit Beck-Fruchter, Israel Gavish, Shira Baram, Yoel Geslevich, Amir Weiss
OBJECTIVE: Thromboelastography (TEG) is a viscoelastic test of hemostasis which allows measurement of the processes of clot initiation, propagation, stabilization, and dissolution in real time. In this study we aimed to evaluate the alterations in coagulation as measured by TEG during In Vitro Fertilization (IVF) stimulation cycles and to investigate whether final oocyte maturation with recombinant hCG (rhCG) versus GnRH agonist results in a different coagulation state. STUDY DESIGN: This is a prospective observational study which included fifty-three normogonadotrophic women...
April 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Puneet Bagga, Stephen Pickup, Rachelle Crescenzi, Daniel Martinez, Arijitt Borthakur, Kevin D'Aquilla, Anup Singh, Gaurav Verma, John A Detre, Joel Greenberg, Hari Hariharan, Ravinder Reddy
Glutamate Chemical Exchange Saturation Transfer (GluCEST) MRI is a recently developed technique to image glutamate. In the present study, we evaluated the reproducibility and background contamination to the GluCEST and source of the GluCEST changes in a mouse model of Parkinson's disease. Repeated measurements in five mice demonstrated an intra-animal coefficient of variation (CV) of GluCEST signal to be 2.3 ± 1.3% and inter-animal CV of GluCEST to be 3.3 ± 0.3%. Mice were treated with MPTP to create a localized striatal elevation of glutamate...
February 13, 2018: Scientific Reports
John C Pickup
No abstract text is available yet for this article.
February 2018: Diabetes Technology & Therapeutics
Amanda M Perri, Zvonimir Poljak, Cate Dewey, John C S Harding, Terri L O'Sullivan
The first case of porcine epidemic diarrhea (PED) in Canada was diagnosed in January 2014 in Ontario, approximately 9 months after PED emerged in the United States. An early investigation of the Canadian outbreak suspected that the probable source of the virus was contaminated feed. The objective of this study was to evaluate the role of feed and other possible factors in the early phase of the PED outbreak in Canadian swine herds. The study period of interest for this case-control study was January 22nd to March 1st, 2014...
February 1, 2018: Preventive Veterinary Medicine
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