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https://www.readbyqxmd.com/read/28336607/genome-sequence-of-human-rhinovirus-a22-strain-lancaster-2015
#1
Kate V Atkinson, Lisa A Bishop, Glenn Rhodes, Nicolas Salez, Neil R McEwan, Matthew J Hegarty, Julie Robey, Nicola Harding, Simon Wetherell, Robert M Lauder, Roger W Pickup, Mark Wilkinson, Derek Gatherer
The genome of human rhinovirus A22 (HRV-A22) was assembled by deep sequencing RNA samples from nasopharyngeal swabs. The assembled genome is 8.7% divergent from the HRV-A22 reference strain over its full length, and it is only the second full-length genome sequence for HRV-A22. The new strain is designated strain HRV-A22/Lancaster/2015.
March 23, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28306384/the-dichotomy-of-the-application-of-a-systems-approach-in-uk-healthcare-the-challenges-and-priorities-for-implementation
#2
Laura Pickup, Alexandra Lang, Sarah Atkinson, Sarah Sharples
There is increasing demand for a systems approach within national healthcare guidelines to provide a systematic and sustainable framework for improvements in patient safety. Supported by this is the growing body of evidence within Human Factors/Ergonomics (HFE) healthcare literature for the inclusion of this approach in health service design, provision and evaluation. This paper considers the current interpretation of this within UK healthcare systems and the dichotomy which exists in the challenge to implement a systems approach...
March 17, 2017: Ergonomics
https://www.readbyqxmd.com/read/28303514/euglycemic-ketosis-in-patients-with-type-2-diabetes-on-sglt2-inhibitor-therapy-an-emerging-problem-and-solutions-offered-by-diabetes-technology
#3
A Pfützner, D Klonoff, L Heinemann, N Ejskjaer, J Pickup
Diabetic ketoacidosis is an infrequent but life-threatening acute complication of diabetes, affecting predominantly patients with type 1 diabetes, children, and pregnant women, where ketosis is usually associated with marked hyperglycemia. Recently, an increasing number of cases have been reported of euglycemic diabetic ketoacidosis in patients with type 2 diabetes receiving sodium-glucose cotransporter 2 inhibitor treatment in routine practice. There is a minor, but not negligible diabetic ketoacidosis risk associated with this drug class, which was not seen in randomized clinical trials...
March 17, 2017: Endocrine
https://www.readbyqxmd.com/read/28293828/pm2-5-emissions-from-different-types-of-heavy-duty-truck-a-case-study-and-meta-analysis-of-the-beijing-tianjin-hebei-region
#4
Liying Song, Hongqing Song, Jingyi Lin, Cheng Wang, Mingxu Yu, Xiaoxia Huang, Yu Guan, Xing Wang, Li Du
Beijing-Tianjin-Hebei (BTH) region in China is affected seriously by the hazy weather that has a large impact on human health. PM2.5 is one of the most important reasons for hazy weather. Understanding the PM2.5 emission characteristics from different types of heavy-duty trucks (HDTs) is valuable in policies and regulations to improve urban air quality and mitigate vehicle emission in China. The investigation and analysis on HDT population and PM2.5 emission in BTH region are carried out. The results show that the population and PM2...
March 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28293053/effect-of-melatonin-on-the-outcome-of-assisted-reproductive-technique-cycles-in-women-with-diminished-ovarian-reserve-a-double-blinded-randomized-clinical-trial
#5
Bahia Namavar Jahromi, Sara Sadeghi, Shohreh Alipour, Mohammad Ebrahim Parsanezhad, Shaghayegh Moradi Alamdarloo
Diminished ovarian reserve (DOR) significantly decreases the success rate of the assisted reproductive technique (ART). In this study, we assessed the effect of melatonin on the ART outcomes in women with DOR. A double-blinded, randomized, clinical trial was performed on 80 women with DOR as a pilot study in Shiraz, between 2014 and 2015. DOR was defined as the presence of 2 of the following 3 criteria: 1) anti-Müllerian hormone ≤1, 2) follicle-stimulating hormone ≥10, and 3) bilateral antral follicle count ≤6...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28283043/birmingham-beh%C3%A3-et-s-service-classification-of-disease-and-application-of-the-2014-international-criteria-for-beh%C3%A3-et-s-disease-icbd-to-a-uk-cohort
#6
Tim Blake, Luke Pickup, David Carruthers, Erika Marie Damato, Alastair Denniston, John Hamburger, Claire Maxton, Debbie Mitton, Philip I Murray, Peter Nightingale, Ana Poveda-Gallego, Andrea Richards, Andrew Whallett, Deva Situnayake
BACKGROUND: This study reports on the analysis of the application and diagnostic predictability of the revised 2014 ICBD criteria in an unselected cohort of UK patients, and the ensuing organ associations and patterns of disease. METHODS: A retrospective cohort study was conducted using a database of electronic medical records. Three categories were recognised: clinically defined BD, incomplete BD and rejected diagnoses of BD. We applied the ISG 1990 and ICBD 2014 classification criteria to these subgroups to validate diagnostic accuracy against the multidisciplinary assessment...
March 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28276684/ultrasound-induced-magnetic-imaging-of-tumors-targeted-by-biofunctional-magnetic-nanoparticles
#7
Kai-Wen Huang, Jen-Jie Chieh, Chih-Kuang Yeh, Shu-Hsien Liao, Yi-Yan Lee, Pei-Yi Hsiao, Wen-Chun Wei, Hong-Chang Yang, Herng-Er Horng
Biofunctional magnetic nanoparticles (MNPs) have been widely applied in biomedical engineering. MNPs are used as a contrast medium in magnetic imaging. Current methods of magnetic imaging, such as magnetic particle imaging and magnetic relaxometry, use small amounts of MNPs at target points far from the surface of the patient's body; these methods always consume considerable power to produce magnetic fields of high uniformity or gradient excitations. Some drawbacks, such as a limited imaging region, imaging system shielding, and complex algorithms based on assumptions of MNP properties or environmental factors, also limit the application of MNP methods in clinics...
March 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/28269623/a-framework-for-informing-segmentation-of-in-vivo-mri-with-information-derived-from-ex-vivo-imaging-application-in-the-medial-temporal-lobe
#8
Paul A Yushkevich, Laura Wisse, Daniel Adler, Ranjit Ittyerah, John B Pluta, John L Robinson, Theresa Schuck, John Q Trojanowski, Murray Grossman, John A Detre, Mark A Elliott, Jon B Toledo, Weixia Liu, Stephen Pickup, Sandhitsu R Das, David A Wolk
Automatic segmentation of cortical and subcortical structures is commonplace in brain MRI literature and is frequently used as the first step towards quantitative analysis of structural and functional neuroimaging. Most approaches to brain structure segmentation are based on propagation of anatomical information from example MRI datasets, called atlases or templates, that are manually labeled by experts. The accuracy of automatic segmentation is usually validated against the "bronze" standard of manual segmentation of test MRI datasets...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227881/a-framework-for-informing-segmentation-of-in-vivo-mri-with-information-derived-from-ex-vivo-imaging-application-in-the-medial-temporal-lobe
#9
Paul A Yushkevich, Laura Wisse, Daniel Adler, Ranjit Ittyerah, John B Pluta, John L Robinson, Theresa Schuck, John Q Trojanowski, Murray Grossman, John A Detre, Mark A Elliott, Jon B Toledo, Weixia Liu, Stephen Pickup, Sandhitsu R Das, David A Wolk, Paul A Yushkevich, Laura Wisse, Daniel Adler, Ranjit Ittyerah, John B Pluta, John L Robinson, Theresa Schuck, John Q Trojanowski, Murray Grossman, John A Detre, Mark A Elliott, Jon B Toledo, Weixia Liu, Stephen Pickup, Sandhitsu R Das, David A Wolk, John L Robinson, Jon B Toledo, Stephen Pickup, Weixia Liu, Paul A Yushkevich, Daniel Adler, John Q Trojanowski, Theresa Schuck, David A Wolk, Laura Wisse, Mark A Elliott, Sandhitsu R Das, John A Detre, John B Pluta, Ranjit Ittyerah, Murray Grossman
Automatic segmentation of cortical and subcortical structures is commonplace in brain MRI literature and is frequently used as the first step towards quantitative analysis of structural and functional neuroimaging. Most approaches to brain structure segmentation are based on propagation of anatomical information from example MRI datasets, called atlases or templates, that are manually labeled by experts. The accuracy of automatic segmentation is usually validated against the "bronze" standard of manual segmentation of test MRI datasets...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218833/atomic-force-microscopy-thermally-assisted-microsampling-with-atmospheric-pressure-temperature-ramped-thermal-desorption-ionization-mass-spectrometry-analysis
#10
William D Hoffmann, Vilmos Kertesz, Bernadeta R Srijanto, Gary J Van Berkel
The use of atomic force microscopy controlled nanothermal analysis probes for reproducible spatially resolved thermally assisted sampling of micrometer-sized areas (ca. 11 × 17 μm wide × 2.4 μm deep) from relatively low number-average molecular weight (Mn < 3000) polydisperse thin films of poly(2-vinylpyridine) (P2VP) is presented. Following sampling, the nanothermal analysis probes were moved up from the surface and the probe temperature ramped to liberate the sampled materials into the gas phase for atmospheric pressure chemical ionization and mass spectrometric analysis...
February 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28192024/insulin-pumps
#11
John C Pickup
No abstract text is available yet for this article.
February 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28163265/significant-heparin-effect-on-bovine-embryo-development-during-sexed-in-vitro-fertilization
#12
Li-You An, Sanjeev A Chaubal, Yanhong Liu, Yexiang Chen, Tshimangadzo L Nedambale, Jie Xu, Fei Xue, Juan F Moreno, Shenghong Tao, Giorgio Antonio Presicce, Fuliang DU
The aim of this study was to investigate the effect of different heparin concentrations in the course of sexed in vitro fertilization (IVF), on bovine embryonic development and development to term following embryo transfer (ET). With a total of 9156 oocytes for IVF, sorted as well as unsorted sperm from four bulls had different heparin requirements for achieving the highest rate of development in vitro. However, when optimal heparin concentrations were used (40 to 80 µg/ml), the performance of X-sorted sperm (0...
February 5, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28153805/the-value-of-prognostic-screening-for-patients-with-low-back-pain-in-secondary-care
#13
Emma L Karran, Adrian C Traeger, James H McAuley, Susan L Hillier, Yun-Hom Yau, G Lorimer Moseley
Prognostic screening in patients with low back pain (LBP) offers a practical approach to guiding clinical decisions. Whether screening is helpful in secondary care is unclear. This prospective cohort study in adults with LBP placed on outpatient clinic waiting lists, compared the performance of the short-form Orebro Musculoskeletal Pain Screening Questionnaire (OMPSQ), the PICKUP Tool (PICKUP) and the STarT Back Tool (SBT). We assessed predictive validity for outcome at 4-month follow-up, by calculating estimates of discrimination, calibration and overall performance...
January 30, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28111738/interventions-for-the-prevention-of-ohss-in-art-cycles-an-overview-of-cochrane-reviews
#14
REVIEW
Selma Mourad, Julie Brown, Cindy Farquhar
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) in assisted reproductive technology (ART) cycles is a treatment-induced disease that has an estimated prevalence of 20% to 33% in its mild form and 3% to 8% in its moderate or severe form. These numbers might even be higher for high-risk women such as those with polycystic ovaries or a high oocyte yield from ovum pickup. OBJECTIVES: The objective of this overview is to identify and summarise all evidence from Cochrane systematic reviews on interventions for prevention or treatment of moderate, severe and overall OHSS in couples with subfertility who are undergoing ART cycles...
January 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28090465/does-intrauterine-injection-of-low-molecular-weight-heparin-improve-the-clinical-pregnancy-rate-in-intracytoplasmic-sperm-injection
#15
Ahmed Mohamed Kamel, Yahia El-Faissal, Mona Aboulghar, Ragaa Mansour, Gamal I Serour, Mohamed Aboulghar
OBJECTIVE: Heparin can modulate proteins, and influence processes involved in implantation and trophoblastic development. This study aimed to assess the improvement of clinical pregnancy and implantation rates after local intrauterine injection of low-molecular-weight heparin (LMWH) in patients undergoing intracytoplasmic sperm injection (ICSI). METHODS: A randomised case/control design was followed in women scheduled for ICSI. The study arm was injected with intrauterine LMWH during mock embryo transfer immediately following the ovum pickup procedure, while the control arm was given an intrauterine injection with a similar volume of tissue culture media...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28074385/use-of-a-cd-laser-pickup-head-to-fabricate-microelectrodes-in-polymethylmethacrylate-substrates-for-biosensing-applications
#16
Jehú López-Aparicio, Mathieu Hautefeuille, Sara Herrera-Domínguez, Adriana Razo-de-León, Mariel Cano-Jorge, Ixchetl Rojas-Benito, Mariana Centeno-Sierra, Tatiana Fiordelisio-Coll, Catalina Elizabeth Stern-Forgach
In this work, we report a simple fabrication method for microelectrodes on a polymethylmethacrylate substrate, using a low-cost laser platform based on a CD-DVD unit for direct rapid-prototyping. We used this laser microfabrication technique to etch any desired design on polymethylmethacrylate substrates to produce microchannels with controlled geometry, with a highly repeatable micron-scale resolution. Those shallow microchannels were then filled with a conductive paste of material of our choice that was converted into microelectrodes of desired shapes and geometries after drying...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28062564/tgf-%C3%AE-bone-morphogenetic-protein-and-activin-signaling-and-the-tumor-microenvironment
#17
Michael W Pickup, Philip Owens, Harold L Moses
The cellular and noncellular components surrounding the tumor cells influence many aspects of tumor progression. Transforming growth factor β (TGF-β), bone morphogenetic proteins (BMPs), and activins have been shown to regulate the phenotype and functions of the microenvironment and are attractive targets to attenuate protumorigenic microenvironmental changes. Given the pleiotropic nature of the cytokines involved, a full understanding of their effects on numerous cell types in many contexts is necessary for proper clinical intervention...
January 6, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28059361/fabry-perot-description-for-mie-resonances-of-rectangular-dielectric-nanowire-optical-resonators
#18
Patrick E Landreman, Hamidreza Chalabi, Junghyun Park, Mark L Brongersma
We show that a dielectric nanowire (NW) with a rectangular cross section can effectively be modeled as a Fabry-Perot cavity formed by truncating a dielectric slab waveguide. By calculating the mode indices of the supported waveguide modes and the reflection phase pickup of the guided waves from the end facets, we can numerically predict the spectral locations of optical, Mie-like resonances for such NWs. This type of analysis must be performed twice in order to account for all resonances of these structures, corresponding to light propagating in the vertical or horizontal directions...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28050952/zika-virus-and-assisted-reproductive-technology-to-test-or-not-to-test-that-is-the-question-is-it-an-unnecessary-cost-the-first-two-months-of-mandatory-testing-in-an-outbreak-area-in-rio-de-janeiro-brazil
#19
Maria do Carmo B de Souza, Veronica Raupp, Fernanda Sobrinho, Mariana Menezes, Tatiana R Panaino, Maria A Tamm, Ana C A Mancebo, Ana L R Costa, Roberto A Antunes
OBJECTIVE: Infection by the Zika virus is a Public Health Emergency of International Concern as defined by the World Health Organization. Resolution no. 72, issued by the Collegiate Board of the Brazilian Health Surveillance Agency (ANVISA) on March 30, 2016, made ZKV testing mandatory prior to procedures involving germ cells and tissues. This paper aims to discuss the aforementioned Resolution from the standpoint of evidence and cost-effectiveness of the measures taken within the first two months of mandatory testing...
December 1, 2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/27917900/self-cleaning-of-surfaces-the-role-of-surface-wettability-and-dust-types
#20
Yun-Yun Quan, Li-Zhi Zhang, Rong-Hui Qi, Rong-Rong Cai
The self-cleaning property is usually connected to superhydrophobic surfaces (SHSs) where the dust particles can be easily removed by the rolling motion of droplets. It seems that superhydrophobicity (its durability is questionable nowadays) is a necessity. However here, it is disclosed that self-cleaning can also be realized on an ordinary surface by droplet impinging. The effects of surface wettability and the types of dust particles are considered. The self-cleaning is realized by two steps: (1) the pickup of particles by the water-air interface of an impinging droplet, (2) the release of the impinging droplets from the surface...
December 5, 2016: Scientific Reports
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