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Corey A Lester, Kevin A Look, Michelle A Chui
BACKGROUND: The Centers for Medicare & Medicaid Services (CMS) adopted the proportion of days covered (PDC) calculation for use in their Five-Star Quality Rating System for Medicare Advantage and Prescription Drug Plans. This calculation uses the prescription adjudication date (i.e., date the prescription is billed to the benefits manager by a pharmacy) as a proxy for medication adherence. Adherence programs, such as automatic refill programs, have become commonplace in community pharmacy and have been identified by industry leaders as interfering with the ability to accurately measure adherence using PDC...
November 2016: Journal of Managed Care & Specialty Pharmacy
John R Kirtley, Lisa Paulius, Aaron J Rosenberg, Johanna C Palmstrom, Connor M Holland, Eric M Spanton, Daniel Schiessl, Colin L Jermain, Jonathan Gibbons, Y-K-K Fung, Martin E Huber, Daniel C Ralph, Mark B Ketchen, Gerald W Gibson, Kathryn A Moler
Superconducting QUantum Interference Device (SQUID) microscopy has excellent magnetic field sensitivity, but suffers from modest spatial resolution when compared with other scanning probes. This spatial resolution is determined by both the size of the field sensitive area and the spacing between this area and the sample surface. In this paper we describe scanning SQUID susceptometers that achieve sub-micron spatial resolution while retaining a white noise floor flux sensitivity of ≈2μΦ0/Hz(1/2). This high spatial resolution is accomplished by deep sub-micron feature sizes, well shielded pickup loops fabricated using a planarized process, and a deep etch step that minimizes the spacing between the sample surface and the SQUID pickup loop...
September 2016: Review of Scientific Instruments
Xiaoke Zeng, Aaron M Kociolek, Muhammad Idrees Khan, Stephan Milosavljevic, Brenna Bath, Catherine Trask
Whole body vibration is a significant physical risk factor associated with low back pain. This study assessed farmers' exposure to whole body vibration on the Canadian Prairies according to ISO 2631-1. Eighty-seven vibration measurements were collected with a triaxial accelerometer embedded in a rubber seat pad at the operator-seat interface of agricultural machinery, including tractors, combines, pickup trucks, grain trucks, sprayers, swathers, all-terrain vehicles, and skid steers. Whole body vibration was highest in the vertical axis, with a mean (range) frequency-weighted root mean squared acceleration of 0...
October 26, 2016: Ergonomics
Yonatan Kahn, Benjamin R Safdi, Jesse Thaler
When ultralight axion dark matter encounters a static magnetic field, it sources an effective electric current that follows the magnetic field lines and oscillates at the axion Compton frequency. We propose a new experiment to detect this axion effective current. In the presence of axion dark matter, a large toroidal magnet will act like an oscillating current ring, whose induced magnetic flux can be measured by an external pickup loop inductively coupled to a SQUID magnetometer. We consider both resonant and broadband readout circuits and show that a broadband approach has advantages at small axion masses...
September 30, 2016: Physical Review Letters
Sue Hignett, Alexandra Lang, Laura Pickup, Christine Ives, Mike Fray, Celine McKeown, Sarah Tapley, Matthew Woodward, Paul Bowie
What prevents the delivery of effective, high quality, and safe healthcare in the National Health Service (NHS) in England? This paper presents 760 challenges which 330 NHS staff reported as preventing the delivery of effective, high quality and safe care. Some problems have been known for over 25 years (staff shortages, finance and patient complexity) but other challenges raise questions about the commitment of the NHS to patient and staff safety. For example Organisational Culture leading to 'stifling bureaucracy', 'odds stacked against smooth […] working' and Workload resulting in 'firefighting daily' and 'perpetual crisis mode'...
October 7, 2016: Ergonomics
Tanveer Sheikh Waqas, Binit Shrestha, M L Theerathavaj Srithavaj, Natdhanai Chotprasert
Excessive movement of the underlying tissue bed can lead to poor retention of an implant-retained silicone auricular prosthesis. This article describes a 2-step impression technique with a secondary functional pickup impression of the wax pattern. A wide range of tissue movements can be recorded while maintaining a stable relationship between the abutment analog assembly and retentive elements. The definitive cast is modified accordingly to provide an accurate reproduction of the patient's tissues during function, thus, increasing the overall retention and stability of the definitive prosthesis...
September 24, 2016: Journal of Prosthetic Dentistry
L E M Wisse, D H Adler, R Ittyerah, J B Pluta, J L Robinson, T Schuck, J Q Trojanowski, M Grossman, J A Detre, M A Elliott, J B Toledo, W Liu, S Pickup, S R Das, D A Wolk, P A Yushkevich
Multiple techniques for quantification of hippocampal subfields from in vivo MRI have been proposed. Linking in vivo MRI to the underlying histology can help validate and improve these techniques. High-resolution ex vivo MRI can provide an intermediate modality to map information between these very different imaging modalities. This article evaluates the ability to match information between in vivo and ex vivo MRI in the same subjects. We perform rigid and deformable registration on 10 pairs of in vivo (3 T, 0...
September 24, 2016: Cerebral Cortex
Zhan Yang, Yaqiong Wang, Bin Yang, Guanghui Li, Tao Chen, Masahiro Nakajima, Lining Sun, Toshio Fukuda
Carbon nanotubes (CNT) have been developed in recent decades for nanodevices such as nanoradios, nanogenerators, carbon nanotube field effect transistors (CNTFETs) and so on, indicating that the application of CNTs for nanoscale electronics may play a key role in the development of nanotechnology. Nanorobotics manipulation systems are a promising method for nanodevice construction and assembly. For the purpose of constructing three-dimensional CNTFETs, a nanorobotics manipulation system with 16 DOFs was developed for nanomanipulation of nanometer-scale objects inside the specimen chamber of a scanning electron microscope (SEM)...
2016: Sensors
Chuanfu Huang, Vitaly V Kresin, Andriy Pysanenko, Michal Fárník
Electron ionization is a common tool for the mass spectrometry of atomic and molecular clusters. Any cluster can be ionized efficiently by sufficiently energetic electrons, but concomitant fragmentation can seriously obstruct the goal of size-resolved detection. We present a new general method to assess the original neutral population of the cluster beam. Clusters undergo a sticking collision with a molecule from a crossed beam, and the velocities of neat and doped cluster ion peaks are measured and compared...
September 14, 2016: Journal of Chemical Physics
Marco Oberscheider, Patrick Hirsch
BACKGROUND: Efficient transport of non-emergency patients is crucial for ambulance service providers to cope with increased demand resulting from aging Western societies. This paper deals with the optimization of the patient transport operations of the Red Cross of Lower Austria, which is the main provider in this state. Different quality levels of the provided service - expressed by time windows, feasible maximum ride times and exclusive transports - are tested and analyzed on real-life instances to show daily impacts on the provider's resources...
2016: BMC Health Services Research
Jongil Lim, Christopher J Palmer, Michael A Busa, Avelino Amado, Luis D Rosado, Scott W Ducharme, Darnell Simon, Richard E A Van Emmerik
The pickup of visual information is critical for controlling movement and maintaining situational awareness in dangerous situations. Altered coordination while wearing protective equipment may impact the likelihood of injury or death. This investigation examined the consequences of load magnitude and distribution on situational awareness, segmental coordination and head gaze in several protective equipment ensembles. Twelve soldiers stepped down onto force plates and were instructed to quickly and accurately identify visual information while establishing marksmanship posture in protective equipment...
September 3, 2016: Ergonomics
Vassilis Fragoulakis, Chris P Pescott, Jesper M J Smeenk, Evert J P van Santbrink, G Jur E Oosterhuis, Frank J M Broekmans, Nikos Maniadakis
BACKGROUND AND OBJECTIVE: Subfertility represents a multidimensional problem associated with significant distress and impaired social well-being. In the Netherlands, an estimated 50,000 couples visit their general practitioner and 30,000 couples seek medical specialist care for subfertility. We conducted an economic evaluation comparing recombinant human follicle-stimulating hormone (follitropin alfa, r-hFSH, Gonal-F(®)) with two classes of urinary gonadotrophins-highly purified human menopausal gonadotrophin (hp-HMG, Menopur(®)) and urinary follicle-stimulating hormone (uFSH, Fostimon(®))-for ovarian stimulation in women undergoing in vitro fertilization (IVF) treatment in the Netherlands...
August 31, 2016: Applied Health Economics and Health Policy
L H Oliveira, A B Nascimento, P L J Monteiro, M M Guardieiro, M C Wiltbank, R Sartori
The objective of this study was to test the hypothesis that high-producing dairy cows become increasingly resistant to insulin throughout lactation and that, consequently, oocyte quality is compromised. We used Holstein cows at 50 (51.5 ± 3.7; n = 30), 100 (102.3 ± 9.4; n = 30), and 150 (154.5 ± 18.9; n = 30) days in milk (DIM). We measured circulating insulin and glucose and performed a glucose tolerance test (GTT) after 5 h of fasting. To evaluate oocyte quality, we performed ovum pickup on the day before the GTT (581 oocytes)...
August 24, 2016: Journal of Dairy Science
Elena Boto, Richard Bowtell, Peter Krüger, T Mark Fromhold, Peter G Morris, Sofie S Meyer, Gareth R Barnes, Matthew J Brookes
Magnetoencephalography (MEG) is a sophisticated tool which yields rich information on the spatial, spectral and temporal signatures of human brain function. Despite unique potential, MEG is limited by a low signal-to-noise ratio (SNR) which is caused by both the inherently small magnetic fields generated by the brain, and the scalp-to-sensor distance. The latter is limited in current systems due to a requirement for pickup coils to be cryogenically cooled. Recent work suggests that optically-pumped magnetometers (OPMs) might be a viable alternative to superconducting detectors for MEG measurement...
2016: PloS One
Luke Pickup, Sarah Bowater, Sara Thorne, Paul Clift, Lucy Hudsmith
No abstract text is available yet for this article.
November 15, 2016: International Journal of Cardiology
José Felipe W Sprícigo, Severino Bernardino Sena Netto, Carolle Vieira Muterlle, Sarah de Andrade Dias Rodrigues, Ligiane Oliveira Leme, Ana Luiza Guimarães, Felippe Manoel Costa Caixeta, Maurício Machain Franco, Ivo Pivato, Margot Alves Nunes Dode
Embryo production by intrafollicular oocyte transfer (IFOT) represents an alternative for production of a large number of embryos without requiring any hormones and only basic laboratory handling. We aimed to (1) evaluate the efficiency of IFOT using immature oocytes (IFIOT) and (2) compare embryo development after IFIOT using fresh or vitrified immature oocytes. First, six IFIOTs were performed using immature oocytes obtained by ovum pickup. After insemination and uterine flush for embryo recovery, 21.3% of total transferred structures were recovered excluding the recipient's own oocyte or embryo, and of those, 26% (5...
November 2016: Theriogenology
C Jaton, A Koeck, M Sargolzaei, C A Price, C Baes, F S Schenkel, F Miglior
Multiple embryos can be produced from a heifer or cow donors using an in vivo or an in vitro technique. Comparisons of the number of embryos produced by the same donors as heifers and cows and using different techniques are limited. The main objectives of this study were to assess the genetic correlation between the number of embryos produced by Holstein donors using an in vivo and in vitro technique as a heifer and as a cow. The data set used was recorded by Holstein Canada and included all successful superovulations or ovum pickup and in vitro fertilization procedures performed on Holstein donors for more than 20yr...
October 2016: Journal of Dairy Science
Kun Luo, Matthew R Roberts, Niccoló Guerrini, Nuria Tapia-Ruiz, Rong Hao, Felix Massel, David M Pickup, Silvia Ramos, Yi-Sheng Liu, Jinghua Guo, Alan V Chadwick, Laurent C Duda, Peter G Bruce
Conventional intercalation cathodes for lithium batteries store charge in redox reactions associated with the transition metal cations, e.g., Mn(3+/4+) in LiMn2O4, and this limits the energy storage of Li-ion batteries. Compounds such as Li[Li0.2Ni0.2Mn0.6]O2 exhibit a capacity to store charge in excess of the transition metal redox reactions. The additional capacity occurs at and above 4.5 V versus Li(+)/Li. The capacity at 4.5 V is dominated by oxidation of the O(2-) anions accounting for ∼0.43 e(-)/formula unit, with an additional 0...
September 7, 2016: Journal of the American Chemical Society
Alycia K Buckingham, Michelle L Harvey, Roland A H van Oorschot
The presence of DNA in a criminal investigation often requires scrutiny in relation to how it came to be where it was found. There is a paucity of data with respect to the extent to which one can assume that the last person handling an object, which has previously been touched by others, will contribute to the DNA profile generated from it. There are limited data in detailing the extent to which any foreign DNA is picked-up from a previously touched object and transferred to subsequently touched objects. This study focuses on DNA transfer and persistence on a knife handle after multiple handlings with the knife by different individuals soon after each other, as well as handprints left on flat DNA-free surfaces immediately after touching a knife handle with a known history of prior handling...
July 28, 2016: Forensic Science International. Genetics
Anu Ramaswami, Navneet Kaur Baidwan, Ajay Singh Nagpure
Open municipal solid waste (MSW)-burning is a major source of particulate matter emissions in developing world cities. Despite a legal ban, MSW-burning is observed ubiquitously in Indian cities with little being known about the factors shaping it. This study seeks to uncover social and infrastructural factors that affect MSW-burning at the neighborhood level. We couple physical assessments of the infrastructure provision and the MSW-burning incidences in three different neighborhoods of varying socio-economic status in Delhi, with an accompanying study of the social actors (interviews of waste handlers and households) to explore the extent to which, and potential reasons why, MSW-burning occurs...
November 2016: Waste Management & Research
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