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https://www.readbyqxmd.com/read/28522701/genome-sequence-of-human-papillomavirus-23-strain-hpv-23-lancaster-2015
#1
Kate V Atkinson, Lisa A Bishop, Glenn Rhodes, Nicolas Salez, Neil R McEwan, Matthew J Hegarty, Julie Robey, Nicola Harding, Simon Wetherell, Robert M Lauder, Roger W Pickup, Mark Wilkinson, Derek Gatherer
The genome of human papillomavirus type 23 (HPV-23; family Papillomaviridae, genus Betapapillomavirus, species Betapapillomavirus 2, type 23) was assembled by deep sequencing from nasopharyngeal swabs. The assembled genome is 2.7% divergent over its full length from the single complete genome of HPV-23 in GenBank (accession no. U31781). We named the strain HPV-23/Lancaster/2015.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28517936/in-situ-hydrogel-conditioning-of-tissue-samples-to-enhance-the-drug-s-sensitivity-in-ambient-mass-spectrometry-imaging
#2
Xiaowei Song, Zhigang Luo, Xin Li, Tiegang Li, Zhonghua Wang, Chenglong Sun, Luojiao Huang, Ping Xie, Xiaoyu Liu, Jiuming He, Zeper Abliz
Ion suppression from the tissue matrix has a severe effect on the mass spectrometry imaging (MSI) of drugs. This problem hinders further applications of MSI in preclinical drug research and development. In this study, an in situ hydrogel conditioning method was developed to enhance the sensitivity of air-flow-assisted desorption electrospray ionization (AFADESI)-MSI. Instead of the traditional wash-up or digestion treatment in solvent, this method used a solid phase hydrogel to "wash" tissue sections. It was demonstrated that this in situ hydrogel conditioning method improve the drug signal by as much as 2- to 25-folds in MSI, especially for hydrophobic compounds...
May 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28504166/functionality-of-chitosan-in-batter-formulations-for-coating-of-fish-sticks-effect-on-physicochemical-quality
#3
K A Martin Xavier, Hauzoukim, Nagalakshmi Kannuchamy, Amjad K Balange, M K Chouksey, Venkateshwarlu Gudipati
Chitosan is a natural polymer having diverse applications in food industry. The present study was undertaken to evaluate chitosan as a hydrocolloid in batter composition in developing enrobed fish sticks with better functional properties and improved quality. Different concentrations of chitosan gel were made in acetic acid medium and incorporated into batter for making enrobed fish sticks. Coating parameters, fat uptake, oil reduction, chemical quality parameters, instrumental texture analysis and colour were studied...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28495453/relative-initial-weight-is-associated-with-improved-survival-without-altering-tumor-latency-in-a-translational-rat-model-of-diethylnitrosamine-induced-hepatocellular-carcinoma-and-transarterial-embolization
#4
Ryan M Kiefer, Stephen J Hunt, Santiago Pulido, Stephen Pickup, Emma E Furth, Michael C Soulen, Gregory J Nadolski, Terence P Gade
PURPOSE: To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access. MATERIALS AND METHODS: One hundred thirty-eight male Wistar rats ingested 0.01% DEN in water ad libitum for 12 weeks. T2-weighted magnetic resonance imaging was used for tumor surveillance...
May 9, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28475583/sarcoidosis-in-an-italian-province-prevalence-and-environmental-risk-factors
#5
Deborah Beghè, Luca Dall'Asta, Claudia Garavelli, Augusto Alberto Pastorelli, Marilena Muscarella, Gloria Saccani, Marina Aiello, Ernesto Crisafulli, Massimo Corradi, Paolo Stacchini, Alfredo Chetta, Giuseppina Bertorelli
BACKGROUND AND AIM: Sarcoidosis is a systemic granulomatous inflammatory disease whose causes are still unknown and for which epidemiological data are often discordant. The aim of our study is to investigate prevalence and spatial distribution of cases, and identify environmental exposures associated with sarcoidosis in an Italian province. METHODS: After georeferentiation of cases, the area under study was subdivided with respect to Municipality and Health Districts and to the altitude in order to identify zonal differences in prevalence...
2017: PloS One
https://www.readbyqxmd.com/read/28463313/real-object-pickup-method-of-integral-imaging-using-offset-lens-array
#6
Junkyu Yim, Ki-Hong Choi, Sung-Wook Min
We propose the pickup system of integral imaging using the offset lens array (OLA), which is a useful optical component for both the pickup and display processes. The main purpose of our system is resolving the pseudoscopic image problem of integral imaging. Also, the flipped image of integral imaging that has the wrong perspective information can be removed by adding an external barrier in the display process. In this paper, the above properties are explained in detail, and the experimental results to verify the feasibility of the proposed system are presented...
May 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28452891/child-seat-belt-guidelines-examining-the-4-9-rule-as-the-standard-examining-the-4-9-rule-as-the-standard
#7
Amber M Morse, Mary E Aitken, Samantha H Mullins, Beverly K Miller, Mindy M Pomtree, Erin M Ulloa, Jeffrey S Montgomery, Marie E Saylors
BACKGROUND: Current American Academy of Pediatrics (AAP) recommendations regarding transition from child safety/booster seat to adult safety belt use indicate that children should be at least 4'9", 8 years old, or 80 pounds. Proper fit in the vehicle seat, assessed with a 5 point fit test, should also be met. While most children reach 4'9" around age 8, each child and vehicle presents a unique combination; thus a child may not fit appropriately in all vehicle types using only the 4'9" requirement...
April 27, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28431852/how-well-does-transfer-of-bacterial-pathogens-by-culture-swabs-correlate-with-transfer-by-hands
#8
Anubhav Kanwar, Thriveen S C Mana, Jennifer L Cadnum, Heba Alhmidi, Sreelatha Koganti, Curtis J Donskey
In laboratory testing and in isolation rooms, pickup and transfer of health care-associated pathogens by premoistened rayon swabs correlated well with pickup and transfer by bare hands or moistened gloves. These results suggest that swab cultures provide a useful surrogate indicator of the risk for pathogen pickup and transfer by hands.
April 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28428549/low-noise-time-resolved-optical-sensing-of-electromagnetic-pulses-from-petawatt-laser-matter-interactions
#9
T S Robinson, F Consoli, S Giltrap, S J Eardley, G S Hicks, E J Ditter, O Ettlinger, N H Stuart, M Notley, R De Angelis, Z Najmudin, R A Smith
We report on the development and deployment of an optical diagnostic for single-shot measurement of the electric-field components of electromagnetic pulses from high-intensity laser-matter interactions in a high-noise environment. The electro-optic Pockels effect in KDP crystals was used to measure transient electric fields using a geometry easily modifiable for magnetic field detection via Faraday rotation. Using dielectric sensors and an optical fibre-based readout ensures minimal field perturbations compared to conductive probes and greatly limits unwanted electrical pickup between probe and recording system...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428322/glycemic-control-during-continuous-subcutaneous-insulin-infusion-versus-multiple-daily-insulin-injections-in-type-2-diabetes-individual-patient-data-meta-analysis-and-meta-regression-of-randomized-controlled-trials
#10
REVIEW
John C Pickup, Yves Reznik, Alex J Sutton
OBJECTIVE: To compare glycemic control during continuous subcutaneous insulin infusion (CSII) and multiple daily insulin injections (MDI) in people with type 2 diabetes to identify patient characteristics that determine those best treated by CSII. RESEARCH DESIGN AND METHODS: Randomized controlled trials were selected comparing HbA1c during CSII versus MDI in people with type 2 diabetes. Data sources included Cochrane database and Ovid Medline. We explored patient-level determinants of final HbA1c level and insulin dose using Bayesian meta-regression models of individual patient data and summary effects using two-step meta-analysis...
May 2017: Diabetes Care
https://www.readbyqxmd.com/read/28406194/influenza-c-in-lancaster-uk-in-the-winter-of-2014-2015
#11
Kate V Atkinson, Lisa A Bishop, Glenn Rhodes, Nicolas Salez, Neil R McEwan, Matthew J Hegarty, Julie Robey, Nicola Harding, Simon Wetherell, Robert M Lauder, Roger W Pickup, Mark Wilkinson, Derek Gatherer
Influenza C is not included in the annual seasonal influenza vaccine, and has historically been regarded as a minor respiratory pathogen. However, recent work has highlighted its potential role as a cause of pneumonia in infants. We performed nasopharyngeal or nasal swabbing and/or serum sampling (n = 148) in Lancaster, UK, over the winter of 2014-2015. Using enzyme-linked immunosorbent assay (ELISA), we obtain seropositivity of 77%. By contrast, only 2 individuals, both asymptomatic adults, were influenza C-positive by polymerase chain reaction (PCR)...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28402772/delays-in-emergency-care-and-mortality-during-major-u-s-marathons
#12
Anupam B Jena, N Clay Mann, Leia N Wedlund, Andrew Olenski
BACKGROUND: Large marathons frequently involve widespread road closures and infrastructure disruptions, which may create delays in emergency care for nonparticipants with acute medical conditions who live in proximity to marathon routes. METHODS: We analyzed Medicare data on hospitalizations for acute myocardial infarction or cardiac arrest among Medicare beneficiaries (≥65 years of age) in 11 U.S. cities that were hosting major marathons during the period from 2002 through 2012 and compared 30-day mortality among the beneficiaries who were hospitalized on the date of a marathon, those who were hospitalized on the same day of the week as the day of the marathon in the 5 weeks before or the 5 weeks after the marathon, and those who were hospitalized on the same day as the marathon but in surrounding ZIP Code areas unaffected by the marathon...
April 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28381423/integrin-mediated-traction-force-enhances-paxillin-molecular-associations-and-adhesion-dynamics-that-increase-the-invasiveness-of-tumor-cells-into-a-three-dimensional-extracellular-matrix
#13
Armen H Mekhdjian, FuiBoon Kai, Matthew G Rubashkin, Louis S Prahl, Laralynne M Przybyla, Alexandra L McGregor, Emily S Bell, J Matthew Barnes, Christopher C DuFort, Guanqing Ou, Alice C Chang, Luke Cassereau, Steven J Tan, Michael W Pickup, Jonathan N Lakins, Xin Ye, Michael W Davidson, Jan Lammerding, David J Odde, Alexander R Dunn, Valerie M Weaver
Metastasis requires tumor cells to navigate through a stiff stroma, and to squeeze through confined microenvironments. Whether tumors exploit unique biophysical properties to metastasize remains unclear. Data showed that invading mammary tumor cells, when cultured in a stiffened three-dimensional extracellular matrix that recapitulates the primary tumor stroma, adopt a basal-like phenotype. Metastatic tumor cells and basal-like tumor cells exerted higher integrin-mediated traction forces at the bulk and molecular levels, consistent with a motor-clutch model where motors and clutches are both increased...
April 5, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28372392/squid-based-current-sensing-noise-thermometry-for-quantum-resistors-at-dilution-refrigerator-temperatures
#14
Ethan Kleinbaum, Vidhi Shingla, G A Csáthy
We present a dc Superconducting QUantum Interference Device (SQUID)-based current amplifier with an estimated input referred noise of only 2.3 fA/Hz. Because of such a low amplifier noise, the circuit is useful for Johnson noise thermometry of quantum resistors in the kΩ range down to mK temperatures. In particular, we demonstrate that our circuit does not contribute appreciable noise to the Johnson noise of a 3.25 kΩ resistor down to 16 mK. Our circuit is a useful alternative to the commonly used High Electron Mobility Transistor-based amplifiers, but in contrast to the latter, it offers a much reduced 1/f noise...
March 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28362104/is-geometric-frustration-induced-disorder-a-recipe-for-high-ionic-conductivity
#15
Andre Düvel, Paul Heitjans, Pavel Fedorov, Gudrun Scholz, Giannantonio Cibin, Alan V Chadwick, David M Pickup, Silvia Ramos, Lewis W L Sayle, Emma K L Sayle, Thi X T Sayle, Dean C Sayle
Ionic conductivity is ubiquitous to many industrially important applications such as fuel cells, batteries, sensors, and catalysis. Tunable conductivity in these systems is therefore key to their commercial viability. Here, we show that geometric frustration can be exploited as a vehicle for conductivity tuning. In particular, we imposed geometric frustration upon a prototypical system, CaF2, by ball milling it with BaF2, to create nanostructured Ba1-xCaxF2 solid solutions and increased its ionic conductivity by over 5 orders of magnitude...
April 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28360326/mars-atmospheric-history-derived-from-upper-atmosphere-measurements-of-38-ar-36-ar
#16
B M Jakosky, M Slipski, M Benna, P Mahaffy, M Elrod, R Yelle, S Stone, N Alsaeed
The history of Mars' atmosphere is important for understanding the geological evolution and potential habitability of the planet. We determine the amount of gas lost to space through time using measurements of the upper-atmospheric structure made by the Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft. We derive the structure of (38)Ar/(36)Ar between the homopause and exobase altitudes. Fractionation of argon occurs as a result of loss of gas to space by pickup-ion sputtering, which preferentially removes the lighter atom...
March 31, 2017: Science
https://www.readbyqxmd.com/read/28336607/genome-sequence-of-human-rhinovirus-a22-strain-lancaster-2015
#17
Kate V Atkinson, Lisa A Bishop, Glenn Rhodes, Nicolas Salez, Neil R McEwan, Matthew J Hegarty, Julie Robey, Nicola Harding, Simon Wetherell, Robert M Lauder, Roger W Pickup, Mark Wilkinson, Derek Gatherer
The genome of human rhinovirus A22 (HRV-A22) was assembled by deep sequencing RNA samples from nasopharyngeal swabs. The assembled genome is 8.7% divergent from the HRV-A22 reference strain over its full length, and it is only the second full-length genome sequence for HRV-A22. The new strain is designated strain HRV-A22/Lancaster/2015.
March 23, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28306384/the-dichotomy-of-the-application-of-a-systems-approach-in-uk-healthcare-the-challenges-and-priorities-for-implementation
#18
Laura Pickup, Alexandra Lang, Sarah Atkinson, Sarah Sharples
There is increasing demand for a systems approach within national healthcare guidelines to provide a systematic and sustainable framework for improvements in patient safety. Supported by this is the growing body of evidence within Human Factors/Ergonomics (HFE) healthcare literature for the inclusion of this approach in health service design, provision and evaluation. This paper considers the current interpretation of this within UK healthcare systems and the dichotomy which exists in the challenge to implement a systems approach...
March 24, 2017: Ergonomics
https://www.readbyqxmd.com/read/28303514/euglycemic-ketosis-in-patients-with-type-2-diabetes-on-sglt2-inhibitor-therapy-an-emerging-problem-and-solutions-offered-by-diabetes-technology
#19
A Pfützner, D Klonoff, L Heinemann, N Ejskjaer, J Pickup
Diabetic ketoacidosis is an infrequent but life-threatening acute complication of diabetes, affecting predominantly patients with type 1 diabetes, children, and pregnant women, where ketosis is usually associated with marked hyperglycemia. Recently, an increasing number of cases have been reported of euglycemic diabetic ketoacidosis in patients with type 2 diabetes receiving sodium-glucose cotransporter 2 inhibitor treatment in routine practice. There is a minor, but not negligible diabetic ketoacidosis risk associated with this drug class, which was not seen in randomized clinical trials...
April 2017: Endocrine
https://www.readbyqxmd.com/read/28293828/pm2-5-emissions-from-different-types-of-heavy-duty-truck-a-case-study-and-meta-analysis-of-the-beijing-tianjin-hebei-region
#20
Liying Song, Hongqing Song, Jingyi Lin, Cheng Wang, Mingxu Yu, Xiaoxia Huang, Yu Guan, Xing Wang, Li Du
Beijing-Tianjin-Hebei (BTH) region in China is affected seriously by the hazy weather that has a large impact on human health. PM2.5 is one of the most important reasons for hazy weather. Understanding the PM2.5 emission characteristics from different types of heavy-duty trucks (HDTs) is valuable in policies and regulations to improve urban air quality and mitigate vehicle emission in China. The investigation and analysis on HDT population and PM2.5 emission in BTH region are carried out. The results show that the population and PM2...
March 14, 2017: Environmental Science and Pollution Research International
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