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https://www.readbyqxmd.com/read/28090465/does-intrauterine-injection-of-low-molecular-weight-heparin-improve-the-clinical-pregnancy-rate-in-intracytoplasmic-sperm-injection
#1
Ahmed Mohamed Kamel, Yahia El-Faissal, Mona Aboulghar, Ragaa Mansour, Gamal I Serour, Mohamed Aboulghar
OBJECTIVE: Heparin can modulate proteins, and influence processes involved in implantation and trophoblastic development. This study aimed to assess the improvement of clinical pregnancy and implantation rates after local intrauterine injection of low-molecular-weight heparin (LMWH) in patients undergoing intracytoplasmic sperm injection (ICSI). METHODS: A randomised case/control design was followed in women scheduled for ICSI. The study arm was injected with intrauterine LMWH during mock embryo transfer immediately following the ovum pickup procedure, while the control arm was given an intrauterine injection with a similar volume of tissue culture media...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28074385/use-of-a-cd-laser-pickup-head-to-fabricate-microelectrodes-in-polymethylmethacrylate-substrates-for-biosensing-applications
#2
Jehú López-Aparicio, Mathieu Hautefeuille, Sara Herrera-Domínguez, Adriana Razo-de-León, Mariel Cano-Jorge, Ixchetl Rojas-Benito, Mariana Centeno-Sierra, Tatiana Fiordelisio-Coll, Catalina Elizabeth Stern-Forgach
In this work, we report a simple fabrication method for microelectrodes on a polymethylmethacrylate substrate, using a low-cost laser platform based on a CD-DVD unit for direct rapid-prototyping. We used this laser microfabrication technique to etch any desired design on polymethylmethacrylate substrates to produce microchannels with controlled geometry, with a highly repeatable micron-scale resolution. Those shallow microchannels were then filled with a conductive paste of material of our choice that was converted into microelectrodes of desired shapes and geometries after drying...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28062564/tgf-%C3%AE-bone-morphogenetic-protein-and-activin-signaling-and-the-tumor-microenvironment
#3
Michael W Pickup, Philip Owens, Harold L Moses
The cellular and noncellular components surrounding the tumor cells influence many aspects of tumor progression. Transforming growth factor β (TGF-β), bone morphogenetic proteins (BMPs), and activins have been shown to regulate the phenotype and functions of the microenvironment and are attractive targets to attenuate protumorigenic microenvironmental changes. Given the pleiotropic nature of the cytokines involved, a full understanding of their effects on numerous cell types in many contexts is necessary for proper clinical intervention...
January 6, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28059361/fabry-perot-description-for-mie-resonances-of-rectangular-dielectric-nanowire-optical-resonators
#4
Patrick E Landreman, Hamidreza Chalabi, Junghyun Park, Mark L Brongersma
We show that a dielectric nanowire (NW) with a rectangular cross section can effectively be modeled as a Fabry-Perot cavity formed by truncating a dielectric slab waveguide. By calculating the mode indices of the supported waveguide modes and the reflection phase pickup of the guided waves from the end facets, we can numerically predict the spectral locations of optical, Mie-like resonances for such NWs. This type of analysis must be performed twice in order to account for all resonances of these structures, corresponding to light propagating in the vertical or horizontal directions...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28050952/zika-virus-and-assisted-reproductive-technology-to-test-or-not-to-test-that-is-the-question-is-it-an-unnecessary-cost-the-first-two-months-of-mandatory-testing-in-an-outbreak-area-in-rio-de-janeiro-brazil
#5
Maria do Carmo B de Souza, Veronica Raupp, Fernanda Sobrinho, Mariana Menezes, Tatiana R Panaino, Maria A Tamm, Ana C A Mancebo, Ana L R Costa, Roberto A Antunes
OBJECTIVE: Infection by the Zika virus is a Public Health Emergency of International Concern as defined by the World Health Organization. Resolution no. 72, issued by the Collegiate Board of the Brazilian Health Surveillance Agency (ANVISA) on March 30, 2016, made ZKV testing mandatory prior to procedures involving germ cells and tissues. This paper aims to discuss the aforementioned Resolution from the standpoint of evidence and cost-effectiveness of the measures taken within the first two months of mandatory testing...
December 1, 2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/27917900/self-cleaning-of-surfaces-the-role-of-surface-wettability-and-dust-types
#6
Yun-Yun Quan, Li-Zhi Zhang, Rong-Hui Qi, Rong-Rong Cai
The self-cleaning property is usually connected to superhydrophobic surfaces (SHSs) where the dust particles can be easily removed by the rolling motion of droplets. It seems that superhydrophobicity (its durability is questionable nowadays) is a necessity. However here, it is disclosed that self-cleaning can also be realized on an ordinary surface by droplet impinging. The effects of surface wettability and the types of dust particles are considered. The self-cleaning is realized by two steps: (1) the pickup of particles by the water-air interface of an impinging droplet, (2) the release of the impinging droplets from the surface...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27914000/from-transformation-to-metastasis-deconstructing-the-extracellular-matrix-in-breast-cancer
#7
Shelly Kaushik, Michael W Pickup, Valerie M Weaver
The extracellular matrix (ECM) is a guiding force that regulates various developmental stages of the breast. In addition to providing structural support for the cells, it mediates epithelial-stromal communication and provides cues for cell survival, proliferation, and differentiation. Perturbations in ECM architecture profoundly influence breast tumor progression and metastasis. Understanding how a dysregulated ECM can facilitate malignant transformation is crucial to designing treatments to effectively target the tumor microenvironment...
December 2016: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/27908443/a-retrospective-validation-study-of-three-models-to-estimate-the-probability-of-malignancy-in-patients-with-small-pulmonary-nodules-from-a-tertiary-oncology-follow-up-centre
#8
A Talwar, N M Rahman, T Kadir, L C Pickup, F Gleeson
AIM: To estimate the probability of malignancy in small pulmonary nodules (PNs) based on clinical and radiological characteristics in a non-screening population that includes patients with a prior history of malignancy using three validated models. MATERIALS AND METHODS: Retrospective data on clinical and radiological characteristics was collected from the medical records of 702 patients (379 men, 323 women; range 19-94 years) with PNs ≤12 mm in diameter at a single centre...
February 2017: Clinical Radiology
https://www.readbyqxmd.com/read/27908125/a-h%C3%A3-ckel-source-sink-potential-theory-of-pauli-spin-blockade-in-molecular-electronic-devices
#9
Barry T Pickup, Patrick W Fowler, Irene Sciriha
This paper shows how to include Pauli (exclusion principle) effects within a treatment of ballistic molecular conduction that uses the tight-binding Hückel Hamiltonian and the source-sink-potential (SSP) method. We take into account the many-electron ground-state of the molecule and show that we can discuss ballistic conduction for a specific molecular device in terms of four structural polynomials. In the standard one-electron picture, these are characteristic polynomials of vertex-deleted graphs, with spectral representations in terms of molecular-orbital eigenvectors and eigenvalues...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27896398/acute-liver-effects-disposition-and-metabolic-fate-of-14-c-fenclozic-acid-following-oral-administration-to-normal-and-bile-cannulated-male-c57bl-6j-mice
#10
Kathryn Pickup, Scott Martin, Elizabeth A Partridge, Huw B Jones, Jonathan Wills, Tim Schulz-Utermoehl, Alan McCarthy, Alison Rodrigues, Chris Page, Kerry Ratcliffe, Sunil Sarda, Ian D Wilson
The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed distribution into all tissues except the brain, with radioactivity still detectable in blood, kidney and liver at 72 h post-dose. Mice dosed with [(14)C]-fenclozic acid showed acute centrilobular hepatocellular necrosis, but no other regions of the liver were affected...
November 28, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27890133/blood-sampling-two-sides-to-the-story
#11
Laura Pickup, Sarah Atkinson, Erik Hollnagel, Paul Bowie, Sandra Gray, Sam Rawlinson, Kate Forrester
This study aimed to investigate why there is variability in taking blood. A multi method Pilot study was completed in four National Health Service Scotland hospitals. Human Factors/Ergonomics principles were applied to analyse data from 50 observations, 15 interviews and 12-months of incident data from all Scottish hospitals. The Functional Resonance Analysis Method (FRAM) was used to understand why variability may influence blood sampling functions. The analysis of the 61 pre blood transfusion sampling incidents highlighted limitations in the data collected to understand factors influencing performance...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27886651/foam-mat-freeze-drying-of-bifidobacterium-longum-ro175-viability-and-refrigerated-storage-stability
#12
Danilo Izquierdo-López, Jacques Goulet, Cristina Ratti
Foaming as a pretreatment was used prior to freeze-drying of Bifidobacterium longum RO175 to investigate the potential acceleration of the drying rate and increase in microorganism viability after the process. A study on storage of foamed and nonfoamed freeze-dried products at 4 °C completed this study. B. longum RO175 in foamed medium could be freeze-dried in 1/7 to 1/4 of the time required for nonfoamed suspensions. In addition, foamed suspensions presented higher viability immediately after freeze-drying (13...
January 2017: Journal of Food Science
https://www.readbyqxmd.com/read/27827906/t%C3%AE-riii-expression-in-human-breast-cancer-stroma-and-the-role-of-soluble-t%C3%AE-riii-in-breast-cancer-associated-fibroblasts
#13
Bojana Jovanović, Michael W Pickup, Anna Chytil, Agnieszka E Gorska, Kimberly C Johnson, Harold L Moses, Philip Owens
The TGF-β pathway plays a major role in tumor progression through regulation of epithelial and stromal cell signaling. Dysfunction of the pathway can lead to carcinoma progression and metastasis. To gain insight into the stromal role of the TGF-β pathway in breast cancer, we performed laser capture microdissection (LCM) from breast cancer patients and reduction mammoplasty patients. Microdissected tumor stroma and normal breast stroma were examined for gene expression. Expression of the TGF-β type III receptor (TGFBR3) was greatly decreased in the tumor stroma compared to control healthy breast tissue...
November 4, 2016: Cancers
https://www.readbyqxmd.com/read/27820599/tissue-mechanics-promote-idh1-dependent-hif1%C3%AE-tenascin-c-feedback-to-regulate-glioblastoma%C3%A2-aggression
#14
Yekaterina A Miroshnikova, Janna K Mouw, J Matthew Barnes, Michael W Pickup, Johnathan N Lakins, Youngmi Kim, Khadjia Lobo, Anders I Persson, Gerald F Reis, Tracy R McKnight, Eric C Holland, Joanna J Phillips, Valerie M Weaver
Increased overall survival for patients with glioma brain tumours is associated with mutations in the metabolic regulator isocitrate dehydrogenase 1 (IDH1). Gliomas develop within a mechanically challenged microenvironment that is characterized by a dense extracellular matrix (ECM) that compromises vascular integrity to induce hypoxia and activate HIF1α. We found that glioma aggression and patient prognosis correlate with HIF1α levels and the stiffness of a tenascin C (TNC)-enriched ECM. Gain- and loss-of-function xenograft manipulations demonstrated that a mutant IDH1 restricts glioma aggression by reducing HIF1α-dependent TNC expression to decrease ECM stiffness and mechanosignalling...
November 7, 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27819054/functional-droplets-that-recognize-collect-and-transport-debris-on-surfaces
#15
Ying Bai, Chia-Chih Chang, Umesh Choudhary, Irem Bolukbasi, Alfred J Crosby, Todd Emrick
We describe polymer-stabilized droplets capable of recognizing and picking up nanoparticles from substrates in experiments designed for transporting hydroxyapatite nanoparticles that represent the principal elemental composition of bone. Our experiments, which are inspired by cells that carry out materials transport in vivo, used oil-in-water droplets that traverse a nanoparticle-coated substrate driven by an imposed fluid flow. Nanoparticle capture is realized by interaction of the particles with chemical functionality embedded within the polymeric stabilizing layer on the droplets...
October 2016: Science Advances
https://www.readbyqxmd.com/read/27802756/approach-for-removing-ghost-images-in-remote-field-eddy-current-testing-of-ferromagnetic-pipes
#16
Q W Luo, Y B Shi, Z G Wang, W Zhang, Y Zhang
In the non-destructive testing of ferromagnetic pipes based on remote field eddy currents, an array of sensing coils is often used to detect local defects. While testing, the image that is obtained by sensing coils exhibits a ghost-image, which originates from both the transmitter and sensing coils passing over the same defects in pipes. Ghost-images are caused by transmitters and lead to undesirable assessments of defects. In order to remove ghost-images, two pickup coils are coaxially set to each other in remote field...
October 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27791210/temperature-dependence-of-cross-effect-dynamic-nuclear-polarization-in-rotating-solids-advantages-of-elevated-temperatures
#17
Michel-Andreas Geiger, Marcella Orwick-Rydmark, Katharina Märker, W Trent Franks, Dmitry Akhmetzyanov, Daniel Stöppler, Maximilian Zinke, Edgar Specker, Marc Nazaré, Anne Diehl, Barth-Jan van Rossum, Fabien Aussenac, Thomas Prisner, Ümit Akbey, Hartmut Oschkinat
Dynamic nuclear polarization exploits electron spin polarization to boost signal-to-noise in magic-angle-spinning (MAS) NMR, creating new opportunities in materials science, structural biology, and metabolomics studies. Since protein NMR spectra recorded under DNP conditions can show improved spectral resolution at 180-200 K compared to 110 K, we investigate the effects of AMUPol and various deuterated TOTAPOL isotopologues on sensitivity and spectral resolution at these temperatures, using proline and reproducibly prepared SH3 domain samples...
October 28, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27783554/is-the-currently-used-prescription-adjudication-date-a-good-proxy-for-calculating-medication-refill-adherence
#18
Corey A Lester, Kevin A Look, Michelle A Chui
BACKGROUND: The Centers for Medicare & Medicaid Services (CMS) adopted the proportion of days covered (PDC) calculation for use in their Five-Star Quality Rating System for Medicare Advantage and Prescription Drug Plans. This calculation uses the prescription adjudication date (i.e., date the prescription is billed to the benefits manager by a pharmacy) as a proxy for medication adherence. Adherence programs, such as automatic refill programs, have become commonplace in community pharmacy and have been identified by industry leaders as interfering with the ability to accurately measure adherence using PDC...
November 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27782557/scanning-squid-susceptometers-with-sub-micron-spatial-resolution
#19
John R Kirtley, Lisa Paulius, Aaron J Rosenberg, Johanna C Palmstrom, Connor M Holland, Eric M Spanton, Daniel Schiessl, Colin L Jermain, Jonathan Gibbons, Y-K-K Fung, Martin E Huber, Daniel C Ralph, Mark B Ketchen, Gerald W Gibson, Kathryn A Moler
Superconducting QUantum Interference Device (SQUID) microscopy has excellent magnetic field sensitivity, but suffers from modest spatial resolution when compared with other scanning probes. This spatial resolution is determined by both the size of the field sensitive area and the spacing between this area and the sample surface. In this paper we describe scanning SQUID susceptometers that achieve sub-micron spatial resolution while retaining a white noise floor flux sensitivity of ≈2μΦ0/Hz(1/2). This high spatial resolution is accomplished by deep sub-micron feature sizes, well shielded pickup loops fabricated using a planarized process, and a deep etch step that minimizes the spacing between the sample surface and the SQUID pickup loop...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27780437/whole-body-vibration-exposure-patterns-in-canadian-prairie-farmers
#20
Xiaoke Zeng, Aaron M Kociolek, Muhammad Idrees Khan, Stephan Milosavljevic, Brenna Bath, Catherine Trask
Whole body vibration is a significant physical risk factor associated with low back pain. This study assessed farmers' exposure to whole body vibration on the Canadian prairies according to ISO 2631-1. Eighty-seven vibration measurements were collected with a triaxial accelerometer embedded in a rubber seat pad at the operator-seat interface of agricultural machinery, including tractors, combines, pickup trucks, grain trucks, sprayers, swathers, all-terrain vehicles, and skid steers. Whole body vibration was highest in the vertical axis, with a mean (range) frequency-weighted root mean squared acceleration of 0...
November 21, 2016: Ergonomics
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