Eugénie Goupil, Danaë Tassy, Carine Bourguet, Christiane Quiniou, Veronica Wisehart, Darlaine Pétrin, Christian Le Gouill, Dominic Devost, Hans H Zingg, Michel Bouvier, Horacio Uri Saragovi, Sylvain Chemtob, William D Lubell, Audrey Claing, Terence E Hébert, Stéphane A Laporte
The prostaglandin F2alpha (PGF2alpha) receptor (FP) is a key regulator of parturition and a target for pharmacological management of preterm labor. However, an incomplete understanding of signaling pathways regulating myometrial contraction hinders the development of improved therapeutics. Here we used a peptidomimetic inhibitor of parturition in mice, PDC113.824, whose structure was based on the NH(2)-terminal region of the second extracellular loop of FP receptor, to gain mechanistic insight underlying FP receptor-mediated cell responses in the context of parturition...
August 13, 2010: Journal of Biological Chemistry