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https://www.readbyqxmd.com/read/28742364/solvent-exchange-leading-to-nanobubble-nucleation-a-molecular-dynamics-study
#1
Qianxiang Xiao, Yawei Liu, Zhenjiang Guo, Zhiping Liu, Detlef Lohse, Xianren Zhang
The solvent exchange procedure has become the most-used protocol to produce surface nanobubbles, while the molecular mechanisms behind the solvent exchange are far from being fully understood. In this paper, we build a simple model and use molecular dynam- ics simulations to investigate the dynamic characteristics of solvent exchange for producing nanobubbles. We find that at the first stage of solvent exchange, there exists an interface between interchanging solvents of different gas solubility. This interface moves towards the substrate gradually as the exchange process proceeds...
July 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28734358/fluorescent-quenching-immune-chromatographic-strips-with-quantum-dots-and-upconversion-nanoparticles-as-fluorescent-donors-for-visual-detection-of-sulfaquinoxaline-in-foods-of-animal-origin
#2
Gaoshuang Hu, Wei Sheng, Jingmin Li, Yan Zhang, Junping Wang, Shuo Wang
In this study, two novel fluorescence quenching immune chromatographic strips (FQICS) were developed to detect sulfaquinoxaline (SQX) in foods of animal origin. These proposed FQICSs were based on fluorescence resonance energy transfer (FRET) from fluorescence donors (quantum dots or upconversion nanoparticles) to fluorescence acceptors (colloidal gold nanoparticles). Compared with traditional colloidal gold-based immune chromatographic strips (ICS), these FQICSs showed positive correlation between the fluorescent signals and the targets, and allowed user to get test results from weak fluorescent signals...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28724769/stlv-1-infection-of-papio-anubis-tax-sequence-heterogeneity-and-t-cell-recognition
#3
James M Termini, Diogo M Magnani, Helen S Maxwell, William Lauer, Iris Castro, Jerilyn Pecotte, Glen N Barber, David I Watkins, Ronald C Desrosiers
Natural infection of baboons with simian T lymphotropic virus (STLV) is a potentially useful model system for study of vaccination against the human virus HTLV. Here we expand the number of available full-length STLV-1 baboon sequences from one to three and relate T cell responses that recognize the immunodominant Tax protein to the tax sequences present in two individual baboons. Continuously growing T cell lines were established from two baboons, 12141 and 12752. Next-generation sequencing (NGS) of complete STLV genome sequences from these lines revealed them to be closely related but distinct from each other and from the STLV-1 baboon sequence in the NCBI sequence database...
July 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28724478/the-stoppa-twin-study-explains-the-exhaled-nitric-oxide-and-asthma-link-by-genetics-and-sensitization
#4
Björn Nordlund, Cecilia Lundholm, Vilhelmina Ullemar, Marianne van Hage, Anne K Örtqvist, Catarina Almqvist
BACKGROUND: The link between asthma and exhaled nitric oxide (FENO) is not completely understood. The aim of this study was to estimate the association between FENO and asthma, taking genetics, sensitization, and inhaled corticosteroids (ICS) into account. METHODS: A total of 681 twins (53% monozygotic [MZ] and 47% dizygotic [DZ]) from the population-based STOPPA study (mean age 12.6 years) were recruited and information on FENO (parts per billion), parental report of current asthma, sensitization to airborne allergens (Phadiatop; IgE ≥0...
August 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28724383/molecular-characterization-and-genetic-relatedness-of-clinically-acinetobacter-baumanii-isolates-conferring-increased-resistance-to-the-first-and-second-generations-of-tetracyclines-in-iran
#5
Zahra Meshkat, Himen Salimizand, Yousef Amini, Mostafa Khakshoor, Davoud Mansouri, Hadi Farsiani, Kiarash Ghazvini, Adel Najafi
BACKGROUND: The increasing resistance of Acinetobacter baumannii to antibiotics has recently been regarded as a notable therapeutic difficulty. Evaluating resistance rates of some A. baumannii isolates to tetracyclines had an impact on understanding the antibiotic resistance dissemination. By comparing genetic characteristics and relatedness of A. baumannii isolates, we are able to determine the transition dynamics of outbreak isolates. METHODS: A total of 72 non-duplicate isolates of A...
July 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28722791/treatment-evaluation-using-lung-sound-analysis-in-asthmatic-children
#6
Chizu Habukawa, Katsumi Murakami, Mitsuru Endoh, Noriaki Horii, Yukio Nagasaka
BACKGROUND AND OBJECTIVE: Non-invasive assessment of treatment and prediction of attacks in asthmatic children do not yet exist. Lung sound analysis can non-invasively evaluate airway obstruction. We used a recently developed technology for analysing lung sounds using ic700 (index of the chest wall at 700 Hz, sound intensity at 700 Hz) to evaluate response to inhaled corticosteroid (ICS) in asthmatic children. METHOD: Seventy asthmatic children, including infants, underwent lung sound recording in the asymptomatic state prior to and 1, 2, 4, 6 and 8 weeks after ICS treatment, and asthma control was assessed at 10 weeks...
July 19, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28721202/defining-the-inflammatory-signature-of-human-lung-explant-tissue-in-the-presence-and-absence-of-glucocorticoid
#7
Tracy L Rimington, Emily Hodge, Charlotte K Billington, Sangita Bhaker, Binaya K C, Iain Kilty, Scott Jelinsky, Ian P Hall, Ian Sayers
BACKGROUND:  Airway inflammation is a feature of many respiratory diseases and there is a need for newer, more effective anti-inflammatory compounds. The aim of this study was to develop an ex vivo human lung explant model which can be used to help study the mechanisms underlying inflammatory responses and which can provide a tool to aid drug discovery for inflammatory respiratory diseases such as asthma and COPD. METHOD:  Parenchymal lung tissue from 6 individual donors was dissected and cultured with two pro-inflammatory stimuli, lipopolysaccharide (LPS) (1 µg/ml) and interleukin-1 beta (IL-1β) (10 ng/ml) in the presence or absence of dexamethasone (1 µM)...
2017: F1000Research
https://www.readbyqxmd.com/read/28720132/efficacy-and-safety-of-direct-switch-to-indacaterol-glycopyrronium-in-patients-with-moderate-copd-the-crystal-open-label-randomised-trial
#8
Claus F Vogelmeier, Mina Gaga, Maryam Aalamian-Mattheis, Timm Greulich, Jose M Marin, Walter Castellani, Vincent Ninane, Stephen Lane, Xavier Nunez, Francesco Patalano, Andreas Clemens, Konstantinos Kostikas
BACKGROUND: Dual bronchodilation combining a long-acting β2-agonist (LABA) and a long-acting muscarinic antagonist (LAMA) is the preferred choice of treatment recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 guidelines for the management of patients with moderate-to-severe chronic obstructive pulmonary disease (COPD). The once-daily (q.d.) fixed-dose combination (FDC) of LABA, indacaterol 110 μg and LAMA, glycopyrronium 50 μg (IND/GLY 110/50 μg q...
July 18, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28719278/evaluation-of-the-field-performance-of-immunocard-stat-%C3%A2-rapid-diagnostic-test-for-rotavirus-in-dadaab-refugee-camp-and-at-the-kenya-somalia-border
#9
Maurice Ope, Raymond Nyoka, Ahmed Unshur, Fredrick O Oyier, Shafe A Mowlid, Brian Owino, Steve B Ochieng, Charles I Okello, Joel M Montgomery, Burton Wagacha, Aleksandar Galev, Abdikadir Abdow, Mathew D Esona, Jacqueline Tate, David Fitter, Susan T Cookson, Balajee Arunmozhi, Nina Marano
AbstractRotavirus commonly causes diarrhea in children, leading to hospitalization and even death. Rapid diagnostic tests are feasible alternatives for determining rotavirus outbreaks in refugee camps that have inadequate laboratory capacity. We evaluated the field performance of ImmunoCard STAT!(®) Rotavirus (ICS-RV) in Dadaab Refugee Camp and at the Kenya-Somalia border. From May to December 2014, we prospectively enrolled children aged < 5 years hospitalized with acute diarrhea, defined as ≥ 3 episodes of loose stool in 24 hours for < 7 days...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718194/prevalence-of-imaginary-companions-in-japanese-children
#10
Yusuke Moriguchi, Naoya Todo
Having an imaginary companion (IC) is an example of children's pretend play. However, most research regarding children's ICs is from Western cultures. In this study, the prevalence of ICs was assessed among Japanese children (2- to 9-year-old children, N = 800). The developmental (age), biological (sex), and environmental (birth order) effects on Japanese children's ICs were also assessed. Moreover, whether IC status can be an indicator of fantasy orientation in Japanese children was examined. The results revealed that the prevalence of the invisible friend was relatively rare, but the personified object was prevalent in Japanese children...
July 17, 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28716642/long-term-use-of-inhaled-corticosteroids-in-copd-and-the-risk-of-fracture
#11
Anne V Gonzalez, Janie Coulombe, Pierre Ernst, Samy Suissa
INTRODUCTION: It is uncertain whether long-term use of inhaled corticosteroids (ICS), widely used to treat COPD, increases the risk of fracture, particularly in women, in view of the post-menopausal risks. We assessed whether long-term ICS use in patients with COPD increases the risk of hip or upper extremity fractures, and examined sex-related differences. METHODS: The Quebec healthcare databases were used to form a cohort of patients with COPD over 1990-2005, followed until 2007 for the first hip or upper extremity fracture...
July 14, 2017: Chest
https://www.readbyqxmd.com/read/28715822/long-term-cortisol-concentration-in-scalp-hair-of-asthmatic-children-using-inhaled-corticosteroids-a-case-control-study
#12
Maaike P Smit, Ed H G van Leer, Gerard Noppe, Yolanda B de Rijke, Dieneke Kramer van Driel, Erica L T van den Akker
INTRODUCTION: Inhaled corticosteroids (ICS) can interfere with the hypothalamic-pituitary-adrenal (HPA) axis and may lead to adrenal insufficiency, resulting in a decrease of cortisol production. Cortisol levels measured in scalp hair provide a marker for long-term cortisol exposure. Data regarding hair cortisol concentration (HCC) in asthmatic children with ICS therapy are scarce. The aim of this study is to compare HCC in asthmatic children under ICS treatment with a healthy control group...
July 14, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28714745/long-term-use-of-inhaled-corticosteroids-and-risk-of-upper-respiratory-tract-infection-in-chronic-obstructive-pulmonary-disease-a-meta-analysis
#13
Mingjin Yang, Hong Chen, Yan Zhang, Yuejun Du, Ying Xu, Ping Jiang, Zhibo Xu
Recent studies have suggested that inhaled corticosteroids (ICS) may be associated with higher risks of tuberculosis and pneumonia in patients with COPD. However, it is not known whether ICS increases the risk of upper respiratory tract infection (URTI). Aim of this study was to explore the relationship between ICS and URTI. Through a comprehensive literature search of PubMed, EMBASE, Cochrane Library, and Google Scholar from inception to March 2016, we identified randomized controlled trials of ICS therapy lasting at least 6 months...
July 17, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28708950/a-real-life-study-on-height-in-prepubertal-asthmatic-children-receiving-inhaled-steroids
#14
Elpis Hatziagorou, Fotis Kirvassilis, Eleana Kouroukli, Vasiliki Avramidou, Dafni Papanikolaou, Despoina Terzi, Maria Karailidou, John Tsanakas, Maria Papagianni, Demosthenes Panagiotakos
INTRODUCTION: Asthma is the most common chronic respiratory disease in children and inhaled corticosteroids (ICS) constitute the first line of treatment for these patients. However, the potential growth-inhibiting effect of ICS has often been a cause of concern for both caregivers as well as physicians, and there still remains conflict regarding their safety profile. OBJECTIVE: To assess whether the administration of ICS in low or medium doses is associated with height reduction in prepubertal children...
July 14, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28707381/radiation-associated-lens-changes-in-the-cardiac-catheterization-laboratory-results-from-the-ic-cataract-cataracts-attributed-to-radiation-in-the-cath-lab-study
#15
Aris Karatasakis, Harilaos S Brilakis, Barbara A Danek, Judit Karacsonyi, Jose Roberto Martinez-Parachini, Phuong-Khanh J Nguyen-Trong, Aya J Alame, Michele K Roesle, Bavana V Rangan, Kenneth Rosenfield, Roxana Mehran, Ehtisham Mahmud, Charles E Chambers, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVE: To examine the relationship between occupational exposure to ionizing radiation and the prevalence of lens changes in interventional cardiologists (ICs) and catheterization laboratory ("cath-lab") staff. BACKGROUND: Exposure to ionizing radiation is associated with the development of lens opacities. ICs and cath-lab staff can receive high doses of ionizing radiation without protection, and may thus be at risk for lens opacity formation. METHODS: We conducted a cross-sectional study at an interventional cardiology conference...
July 14, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28707060/the-psychological-significance-of-play-with-imaginary-companions-in-early-childhood
#16
Tracy R Gleason
Although social play is common to many species, humans are unique in their ability to extract some of the benefits of social play through imagination. For example, in play with imaginary companions (ICs), children often practice skills that might be useful for later adaptive social, relational, and emotional functioning. While play with ICs does not provide the same immediate feedback that play with real others affords, this imagined, quasisocial context allows children to experiment with or rehearse events that might occur in real relationships...
July 13, 2017: Learning & Behavior
https://www.readbyqxmd.com/read/28701310/deletion-of-%C3%AE-1-integrin-in-collecting-duct-principal-cells-leads-to-tubular-injury-and-renal-medullary-fibrosis
#17
Fahmy A Mamuya, Dongping Xie, Lei Lei, Ming Huang, Kenji Tsuji, Diane E Capen, Baoxue Yang, Ralph Weissleder, Teodor G Păunescu, Hua Jenny Lu
The renal collecting duct (CD) contains two major cell types, intercalated (ICs) and principal cells (PCs). A previous report showed that deletion of β-1 integrin in the entire renal CD causes defective CD morphogenesis resulting in kidney dysfunction. However, subsequent deletion of β-1 integrin specifically in ICs, and PCs respectively did not cause any morphological defects in the CDs. The discrepancy between these studies prompts us to reinvestigate the role of β-1 integrin in CD cells, specifically in the PCs...
July 12, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28700964/clinical-and-laboratory-predictors-of-infectious-complications-in-patients-after-out-of-hospital-cardiac-arrest
#18
Josef Kroupa, Jiri Knot, Jaroslav Ulman, Frantisek Bednar, Alena Dohnalova, Zuzana Motovska
PURPOSE: Identification of clinical and laboratory predictors related to Infectious Complications (ICs) in patients after Out-of-Hospital Cardiac Arrest (OHCA). METHODS: Patients, aged >18, after an OHCA between 9/2013 and 11/2015, surviving >24h, were studied. RESULTS: Study group consisted of 42 patients (mean age 63.4years, 88.1% men). Forty percent of patients had IC; lower respiratory tract infections were most common (87.5% of cases)...
July 4, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28698872/proliferation-of-interstitial-cells-in-the-cyclophosphamide-induced-cystitis-and-the-preventive-effect-of-imatinib
#19
Maria Sancho, Domingo Triguero, Aranzazu Lafuente-Sanchis, Angeles Garcia-Pascual
Cyclophosphamide- (CYP-) induced cystitis in the rat is a well-known model of bladder inflammation that leads to an overactive bladder, a process that appears to involve enhanced nitric oxide (NO) production. We investigated the changes in the number and distribution of interstitial cells (ICs) and in the expression of endothelial NO synthase (eNOS) in the bladder and urethra of rats subjected to either intermediate or chronic CYP treatment. Pronounced hyperplasia and hypertrophy of ICs were evident within the lamina propria and in the muscle layer...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28696803/thai-pediatricians-current-practice-toward-childhood-asthma
#20
Harutai Kamalaporn, Pongpan Chawalitdamrong, Aroonwan Preutthipan
BACKGROUND: Childhood asthma is a substantial health burden in Thailand. Due to a lack of pediatric respiratory specialists (pediatric pulmonologists and allergists; RS), most Thai children are cared for by general pediatricians (pediatric primary care providers (PCP)). OBJECTIVES: We investigated whether current practices of Thai pediatricians complied with asthma guidelines and compared practices (diagnosis and treatments) provided by PCP and RS. METHODS: A cross-sectional study was conducted using electronic surveys including four case scenarios of different asthma phenotypes distributed to Thai pediatricians...
July 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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