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https://www.readbyqxmd.com/read/28035426/diagnostic-imaging-of-dementia-with-lewy-bodies-by-susceptibility-weighted-imaging-of-nigrosomes-versus-striatal-dopamine-transporter-single-photon-emission-computed-tomography-a-retrospective-observational-study
#1
Koji Kamagata, Tomoya Nakatsuka, Ryuji Sakakibara, Yohei Tsuyusaki, Tomohiro Takamura, Kanako Sato, Michimasa Suzuki, Masaaki Hori, Kanako K Kumamaru, Tsutomu Inaoka, Shigeki Aoki, Hitoshi Terada
INTRODUCTION: The characteristics of dementia with Lewy bodies (DLB), Alzheimer's disease (AD) and amnestic mild cognitive impairment (a-MCI) overlap but require different treatments; therefore, it is important to differentiate these pathologies. Assessment of dopamine uptake in the striatum using dopamine transporter (DaT) single-photon emission computed tomography (SPECT) is the gold standard for diagnosing DLB; however, this modality is expensive, time consuming and involves radiation exposure...
December 29, 2016: Neuroradiology
https://www.readbyqxmd.com/read/28002957/development-of-radiolabeled-ligands-targeting-the-glutamate-binding-site-of-the-n-methyl-d-aspartate-receptor-as-potential-imaging-agents-for-brain
#2
Lucia Tamborini, Ying Chen, Catherine A Foss, Andrea Pinto, Andrew G Horti, Stephen F Traynelis, Carlo De Micheli, Ronnie C Mease, Kasper B Hansen, Paola Conti, Martin G Pomper
Abnormal activity of various N-methyl-d-aspartate receptor (NMDAR) subtypes has been implicated in a wide variety of neurological disorders such as Alzheimer's disease, schizophrenia, and epilepsy. Imaging agents for PET and SPECT that target NMDARs in a subtype-selective fashion may enable better characterization of those disorders and enhance drug development. On the basis of a pyrazoline derivative that demonstrated neuroprotective effects in vivo, we synthesized a series of para-substituted analogues and measured their affinities to various NMDAR subtypes...
December 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27941373/added-value-of-combined-semi-quantitative-and-visual-123i-fp-cit-spect-analyses-for-the-diagnosis-of-dementia-with-lewy-bodies
#3
Nicolas Nicastro, Valentina Garibotto, Gilles Allali, Frederic Assal, Pierre R Burkhard
PURPOSE OF THE REPORT: To assess the validity of a semi-quantitative I-FP-CIT SPECT method, compared to the commonly used visual analysis, in patients with probable dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We also studied DLB specific uptake impairment pattern and correlation of uptake in the presence or absence of parkinsonism. MATERIALS AND METHODS: Among 1202 scans performed at our center from 2003 to 2015, we identified 93 subjects with probable DLB (mean age 76...
December 9, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27940650/autopsy-validation-of-123i-fp-cit-dopaminergic-neuroimaging-for-the-diagnosis-of-dlb
#4
Alan J Thomas, Johannes Attems, Sean J Colloby, John T O'Brien, Ian McKeith, Rodney Walker, Lean Lee, David Burn, Debra J Lett, Zuzana Walker
OBJECTIVE: To conduct a validation study of (123)I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane ((123)I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS: Patients >60 years of age with dementia who had undergone (123)I-FP-CIT imaging in research studies and who had donated their brain tissue to the Newcastle Brain Tissue Resource were included. All had structured clinical research assessments, and clinical diagnoses were applied by consensus panels using international diagnostic criteria...
December 9, 2016: Neurology
https://www.readbyqxmd.com/read/27940150/cholinesterase-inhibitors-are-compatible-with-psychosocial-intervention-for-alzheimer-disease-patients-suggested-by-neuroimaging-findings
#5
Kenichi Meguro
We previously reported that the frontal lobe was stimulated by psychosocial intervention for dementia patients, and that the parietal lobe was associated with logical judgment. We hypothesized that the combined therapeutic approach with symptomatic drug treatment can directly stimulate not only attention function but also judgment function indirectly to observing other participants' behaviors. Fifty-two patients with Alzheimer disease underwent the group reminiscence approach with reality orientation, as well as the donepezil treatment...
January 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27922867/the-value-of-99mtc-ecd-spect-with-statistical-image-analysis-on-enhancing-the-early-diagnosis-of-primary-progressive-aphasia
#6
Cheng-Yu Wei, Pai-Yi Chiu, Po-Nien Hou, Hiroshi Matsuda, Guang-Uei Hung
A 64-year-old woman with poor short-term memory was first suspected as early Alzheimer disease. Tc ECD brain SPECT was arranged for differential diagnosis. A small area of mild hypoperfusion was noted in the left temporal lobe on conventional display. Further statistical analysis of SPECT with an easy Z-score imaging system showed large areas of distinct hypoperfusion in left precentral and perisylvian cortical areas, compatible with typical pictures of nonfluent variant primary progressive aphasia (PPA), but no involvement in areas characteristic for Alzheimer disease...
December 3, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27896492/hemianopic-line-bisection-error-in-a-patient-with-alzheimer-s-disease
#7
Heeyoung Kang, Soo-Kyoung Kim, Ki-Jong Park, Nack-Cheon Choi, Oh-Young Kwon, Byeong Hoon Lim
Visual symptoms are frequently observed in posterior cortical atrophy compared to typical amnestic Alzheimer's disease (AD). We report the case of a patient with amnestic AD with long-lasting homonymous hemianopia. A 62-year-old woman, who was diagnosed in amnestic AD, complained of visual disturbance. She had left homonymous hemianopia in the perimetry test and left tactile extinction. Regardless of posture, retinotopically leftward error was observed on 21 cm line bisection test. Brain single photon emission computerized tomography (SPECT) showed bilateral temporoparietal hypoperfusion, which was more severe to the right than left side...
November 28, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27886010/discriminative-properties-of-hippocampal-hypoperfusion-in-marijuana-users-compared-to-healthy-controls-implications%C3%A2-for-marijuana-administration%C3%A2-in%C3%A2-alzheimer-s-dementia
#8
Daniel G Amen, Borhan Darmal, Cyrus A Raji, Weining Bao, Lantie Jorandby, Somayeh Meysami, Cauligi S Raghavendra
BACKGROUND: Few studies have evaluated the impact of marijuana use on regional cerebral blood flow. OBJECTIVE: To determine whether perfusion in specific brain regions on functional neuroimaging, including those affected by Alzheimer's disease pathology, are abnormal in marijuana users compared to controls. METHOD: Persons with a diagnosis of cannabis use disorder by DSM-IV and DSM-V criteria (n = 982) were compared to controls (n = 92) with perfusion neuroimaging with SPECT at rest and at a concentration task...
November 24, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27866729/molecular-imaging-in-the-diagnosis-of-alzheimer-s-disease-and-related-disorders
#9
REVIEW
L Koric, E Guedj, M O Habert, F Semah, P Branger, P Payoux, F Le Jeune
INTRODUCTION: The diagnosis of Alzheimer's disease (AD) and its related disorders rely on clinical criteria. There is, however, a large clinical overlap between the different neurodegenerative diseases affecting cognition and, frequently, there are diagnostic uncertainties with atypical clinical presentations. Current clinical practices can now regularly use positron emission tomography (PET) and single-photon emission computed tomography (SPECT) molecular imaging to help resolve such uncertainties...
December 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27858707/neural-basis-of-apathy-in-patients-with-amnestic-mild-cognitive-impairment
#10
Hiroaki Kazui, Ryuichi Takahashi, Yuki Yamamoto, Kenji Yoshiyama, Hideki Kanemoto, Yukiko Suzuki, Shunsuke Sato, Shingo Azuma, Takashi Suehiro, Eku Shimosegawa, Kazunari Ishii, Toshihisa Tanaka
BACKGROUND: Although apathy is associated with damage to the frontal and temporal lobes in Alzheimer's disease (AD), the crucial regions for apathy in patients with amnestic mild cognitive impairment (aMCI) are unknown. OBJECTIVE: To identify brain regions associated with apathy in aMCI patients. METHODS: The subjects of this study were 98 aMCI patients who were entered in our dementia registry between March 1, 2009 and April 30, 2015 and who satisfied our criteria for aMCI...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27844089/-biomarkers-for-dementia-and-other-neurodegenerative-diseases-current-developments
#11
J Wiltfang, P Lewczuk, M Otto
Cerebrospinal fluid-based neurochemical dementia diagnostics (CSF-NDD) support the early and differential diagnosis of dementia, most importantly the diagnosis of early or preclinical Alzheimer's dementia (AD). Meanwhile CSF-NDD are now recommended for improved exclusion and positive diagnostics of AD by the German national neuropsychiatry S3 dementia guidelines ( www.DGPPN.de ). Meta-analyses of independent international multicenter studies have shown that a combined CSF analysis of amyloid-beta 1-42 (Aβ 1-42, decreased), total tau proteins (increased) and phospho-tau proteins (increased) offers a sensitivity and specificity of 80-90 % for the early and differential diagnosis of AD (AD versus all other)...
December 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27687137/highly-selective-tau-spect-imaging-probes-for-detection-of-neurofibrillary-tangles-in-alzheimer-s-disease
#12
Masahiro Ono, Hiroyuki Watanabe, Ayane Kitada, Kenji Matsumura, Masafumi Ihara, Hideo Saji
Neurofibrillary tangles composed of aggregates of hyperphosphorylated tau proteins are one of the neuropathological hallmarks of Alzheimer's disease (AD) in addition to the deposition of β-amyloid plaques. Since the deposition of tau aggregates is closely associated with the severity of AD, the in vivo detection of tau aggregates may be useful as a biomarker for the diagnosis and progression of AD. In this study, we designed and synthesized a new series of radioiodinated benzoimidazopyridine (BIP) derivatives, and evaluated their utility as single photon emission computed tomography (SPECT) imaging agents targeting tau aggregates in AD brains...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27640073/positive-affect-and-regional-cerebral-blood-flow-in-alzheimer-s-disease
#13
Satoshi Hayashi, Seishi Terada, Shuhei Sato, Etsuko Oshima, Tomoko Miki, Osamu Yokota, Takeshi Ishihara, Norihito Yamada
Quality of life (QOL) has been recently recognized as the central purpose of healthcare, and positive affect is one of the core dimension of QOL. However, positive affect among patients with dementia or Alzheimer's disease (AD) has not received much attention in the medical research field. One hundred sixteen consecutive patients with AD were recruited from the outpatient units of the Memory Clinic of Okayama University Hospital. The positive affect score was evaluated using the positive affect domain of the Quality of Life questionnaire for Dementia (QOL-D)...
October 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27639367/2-arylbenzothiazoles-labeled-with-cpre-99m-tc-co-3-and-evaluated-as-%C3%AE-amyloid-imaging-probes
#14
Jianhua Jia, Kaixiang Zhou, Jiapei Dai, Boli Liu, Mengchao Cui
An array of complexes, (99m)Tc/Re-labeled cyclopentadienyl tricarbonyl and 2-phenyl/pyridylbenzothiazoles, conjugated through an ester linkage were tested as potential β-amyloid (Aβ) probes for SPECT imaging. The [CpRe/(99m)Tc(CO)3] complexes were prepared by double ligand transfer reactions from ferrocene precursors, and the X-ray structure of one rhenium surrogate revealed a classical "piano stool" like geometry. Several of the rhenium complexes displayed high affinity for Aβ1-42 aggregates in in vitro inhibition assays, and they could intensely stain Aβ deposits on brain sections from transgenic mice and Alzheimer's disease (AD) patients...
November 29, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27624723/the-italian-dementia-with-lewy-bodies-study-group-dlb-sindem-toward-a-standardization-of-clinical-procedures-and-multicenter-cohort-studies-design
#15
L Bonanni, A Cagnin, F Agosta, C Babiloni, B Borroni, M Bozzali, A C Bruni, M Filippi, D Galimberti, R Monastero, C Muscio, L Parnetti, D Perani, L Serra, V Silani, P Tiraboschi, A Padovani
Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients' reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer's disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers (from primary to tertiary) to prepare an Italian large longitudinal cohort...
September 13, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27623495/impaired-picture-arrangement-subscores-wais-iii-associated-with-decreased-place-orientation-and-frontal-occipital-blood-flow-in-alzheimer-s-disease-implications-for-social-judgment-dysfunction-the-osaki-tajiri-project
#16
Yuka Kato, Kenichi Meguro, Masahiro Nakatsuka, Kei Nakamura, Masahiro Tsuboi, Satoshi Yamaguchi
Alzheimer's disease (AD) patients manifest not only memory impairment but also deficit of social judgment. However, contrary to frequently recognized deficit, only two neuropsychological tests have been established for assessing "judgment" : the Cognitive Abilities Screening Instrument domain Abstraction & judgment and the Picture Arrangement subscale of WAIS-III. For the former, we previously reported an association with decreased regional cerebral blood flow (rCBF) in the left parietal lobe. Herein, we analyzed the scores of the Picture Arrangement test...
October 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27620458/the-cingulate-island-sign-within-early-alzheimer-s-disease-specific-hypoperfusion-volumes-of-interest-is-useful-for-differentiating-alzheimer-s-disease-from-dementia-with-lewy-bodies
#17
Etsuko Imabayashi, Kota Yokoyama, Tadashi Tsukamoto, Daichi Sone, Kaoru Sumida, Yukio Kimura, Noriko Sato, Miho Murata, Hiroshi Matsuda
BACKGROUND: In addition to occipital hypoperfusion, preserved metabolism of the posterior cingulate gyri (PCG) relative to the precunei is known as the cingulate island sign (CIS) in the patients with dementia with Lewy bodies (DLB). CIS has been detected using [(18)F]fluorodeoxyglucose positron emission tomography but not using brain perfusion single-photon emission computed tomography (SPECT). The purpose of this study was to optimize brain perfusion SPECT to enable differentiation of DLB from Alzheimer's disease (AD) using CIS and occipital hypoperfusion...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27565302/a-spatial-covariance-123-i-5ia-85380-spect-study-of-%C3%AE-4%C3%AE-2-nicotinic-receptors-in-alzheimer-s-disease
#18
Sean J Colloby, Robert H Field, David J Wyper, John T O'Brien, John-Paul Taylor
Alzheimer's disease (AD) is characterized by widespread degeneration of cholinergic neurons, particularly in the basal forebrain. However, the pattern of these deficits and relationship with known brain networks is unknown. In this study, we sought to clarify this and used (123)I-5-iodo-3-[2(S)-2-azetidinylmethoxy] pyridine ((123)5IA-85380) single photon emission computed tomography to investigate spatial covariance of α4β2 nicotinic acetylcholine receptors in AD and healthy controls. Thirteen AD and 16 controls underwent (123)5IA-85380 and regional cerebral blood flow ((99m)Tc-exametazime) single photon emission computed tomography scanning...
July 30, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27540431/brain-18-f-fdg-18-f-florbetaben-pet-ct-123-i-fp-cit-spect-and-cardiac-123-i-mibg-imaging-for-diagnosis-of-a-cerebral-type-of-lewy-body-disease
#19
Axel Van Der Gucht, Laurent Cleret de Langavant, Ophélie Bélissant, Corentin Rabu, Anne-Ségolène Cottereau, Eva Evangelista, Julia Chalaye, Sophie Bonnot-Lours, Gilles Fénelon, Emmanuel Itti
A 67-year-old man was referred for fluctuating neuropsychiatric symptoms, featuring depression, delirious episodes, recurrent visual hallucinations and catatonic syndrome associated with cognitive decline. No parkinsonism was found clinically even under neuroleptic treatment. (18)F-FDG PET/CT showed hypometabolism in the posterior associative cortex including the occipital cortex, suggesting Lewy body dementia, but (123)I-FP-CIT SPECT was normal and cardiac (123)I-MIBG imaging showed no signs of sympathetic denervation...
September 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27398636/-123-i-2%C3%AE-carbomethoxy-3%C3%AE-4-iodophenyl-n-3-fluoropropyl-nortropane-single-photon-emission-computed-tomography-and-123-i-metaiodobenzylguanidine-myocardial-scintigraphy-in-differentiating-dementia-with-lewy-bodies-from-other-dementias-a-comparative-study
#20
Pietro Tiraboschi, Angelo Corso, Ugo Paolo Guerra, Flavio Nobili, Arnoldo Piccardo, Maria Lucia Calcagni, Duccio Volterrani, Diego Cecchin, Mauro Tettamanti, Luigi Antelmi, Simone Vidale, Leonardo Sacco, Maria Merello, Stefano Stefanini, Anna Micheli, Paola Vai, Selene Capitanio, Sara Vincenzina Gabanelli, Riccardo Riva, Patrizia Pinto, Ave Maria Biffi, Cristina Muscio
OBJECTIVE: To compare the diagnostic value of striatal (123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ((123) I-FP-CIT) single photon emission computed tomography (SPECT) and (123) I-metaiodobenzylguanidine ((123) I-MIBG) myocardial scintigraphy in differentiating dementia with Lewy bodies (DLB) from other dementia types. METHODS: This prospective longitudinal study included 30 patients with a clinical diagnosis of DLB and 29 patients with non-DLB dementia (Alzheimer disease, n = 16; behavioral variant frontotemporal dementia, n = 13)...
September 2016: Annals of Neurology
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