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SPECT Alzheimer

Masahiro Ono, Hiroyuki Watanabe, Ayane Kitada, Kenji Matsumura, Masafumi Ihara, Hideo Saji
Neurofibrillary tangles composed of aggregates of hyperphosphorylated tau proteins are one of the neuropathological hallmarks of Alzheimer's disease (AD) in addition to the deposition of β-amyloid plaques. Since the deposition of tau aggregates is closely associated with the severity of AD, the in vivo detection of tau aggregates may be useful as a biomarker for the diagnosis and progression of AD. In this study, we designed and synthesized a new series of radioiodinated benzoimidazopyridine (BIP) derivatives, and evaluated their utility as single photon emission computed tomography (SPECT) imaging agents targeting tau aggregates in AD brains...
September 30, 2016: Scientific Reports
Satoshi Hayashi, Seishi Terada, Shuhei Sato, Etsuko Oshima, Tomoko Miki, Osamu Yokota, Takeshi Ishihara, Norihito Yamada
Quality of life (QOL) has been recently recognized as the central purpose of healthcare, and positive affect is one of the core dimension of QOL. However, positive affect among patients with dementia or Alzheimer's disease (AD) has not received much attention in the medical research field. One hundred sixteen consecutive patients with AD were recruited from the outpatient units of the Memory Clinic of Okayama University Hospital. The positive affect score was evaluated using the positive affect domain of the Quality of Life questionnaire for Dementia (QOL-D)...
October 30, 2016: Psychiatry Research
Jianhua Jia, Kaixiang Zhou, Jiapei Dai, Boli Liu, Mengchao Cui
An array of complexes, (99m)Tc/Re-labeled cyclopentadienyl tricarbonyl and 2-phenyl/pyridylbenzothiazoles, conjugated through an ester linkage were tested as potential β-amyloid (Aβ) probes for SPECT imaging. The [CpRe/(99m)Tc(CO)3] complexes were prepared by double ligand transfer reactions from ferrocene precursors, and the X-ray structure of one rhenium surrogate revealed a classical "piano stool" like geometry. Several of the rhenium complexes displayed high affinity for Aβ1-42 aggregates in in vitro inhibition assays, and they could intensely stain Aβ deposits on brain sections from transgenic mice and Alzheimer's disease (AD) patients...
September 2, 2016: European Journal of Medicinal Chemistry
L Bonanni, A Cagnin, F Agosta, C Babiloni, B Borroni, M Bozzali, A C Bruni, M Filippi, D Galimberti, R Monastero, C Muscio, L Parnetti, D Perani, L Serra, V Silani, P Tiraboschi, A Padovani
Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients' reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer's disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers (from primary to tertiary) to prepare an Italian large longitudinal cohort...
September 13, 2016: Neurological Sciences
Yuka Kato, Kenichi Meguro, Masahiro Nakatsuka, Kei Nakamura, Masahiro Tsuboi, Satoshi Yamaguchi
Alzheimer's disease (AD) patients manifest not only memory impairment but also deficit of social judgment. However, contrary to frequently recognized deficit, only two neuropsychological tests have been established for assessing "judgment" : the Cognitive Abilities Screening Instrument domain Abstraction & judgment and the Picture Arrangement subscale of WAIS-III. For the former, we previously reported an association with decreased regional cerebral blood flow (rCBF) in the left parietal lobe. Herein, we analyzed the scores of the Picture Arrangement test...
October 30, 2016: Psychiatry Research
Etsuko Imabayashi, Kota Yokoyama, Tadashi Tsukamoto, Daichi Sone, Kaoru Sumida, Yukio Kimura, Noriko Sato, Miho Murata, Hiroshi Matsuda
BACKGROUND: In addition to occipital hypoperfusion, preserved metabolism of the posterior cingulate gyri (PCG) relative to the precunei is known as the cingulate island sign (CIS) in the patients with dementia with Lewy bodies (DLB). CIS has been detected using [(18)F]fluorodeoxyglucose positron emission tomography but not using brain perfusion single-photon emission computed tomography (SPECT). The purpose of this study was to optimize brain perfusion SPECT to enable differentiation of DLB from Alzheimer's disease (AD) using CIS and occipital hypoperfusion...
December 2016: EJNMMI Research
Sean J Colloby, Robert H Field, David J Wyper, John T O'Brien, John-Paul Taylor
Alzheimer's disease (AD) is characterized by widespread degeneration of cholinergic neurons, particularly in the basal forebrain. However, the pattern of these deficits and relationship with known brain networks is unknown. In this study, we sought to clarify this and used (123)I-5-iodo-3-[2(S)-2-azetidinylmethoxy] pyridine ((123)5IA-85380) single photon emission computed tomography to investigate spatial covariance of α4β2 nicotinic acetylcholine receptors in AD and healthy controls. Thirteen AD and 16 controls underwent (123)5IA-85380 and regional cerebral blood flow ((99m)Tc-exametazime) single photon emission computed tomography scanning...
July 30, 2016: Neurobiology of Aging
Axel Van Der Gucht, Laurent Cleret de Langavant, Ophélie Bélissant, Corentin Rabu, Anne-Ségolène Cottereau, Eva Evangelista, Julia Chalaye, Sophie Bonnot-Lours, Gilles Fénelon, Emmanuel Itti
A 67-year-old man was referred for fluctuating neuropsychiatric symptoms, featuring depression, delirious episodes, recurrent visual hallucinations and catatonic syndrome associated with cognitive decline. No parkinsonism was found clinically even under neuroleptic treatment. (18)F-FDG PET/CT showed hypometabolism in the posterior associative cortex including the occipital cortex, suggesting Lewy body dementia, but (123)I-FP-CIT SPECT was normal and cardiac (123)I-MIBG imaging showed no signs of sympathetic denervation...
September 2016: Nuclear Medicine and Molecular Imaging
Pietro Tiraboschi, Angelo Corso, Ugo Paolo Guerra, Flavio Nobili, Arnoldo Piccardo, Maria Lucia Calcagni, Duccio Volterrani, Diego Cecchin, Mauro Tettamanti, Luigi Antelmi, Simone Vidale, Leonardo Sacco, Maria Merello, Stefano Stefanini, Anna Micheli, Paola Vai, Selene Capitanio, Sara Vincenzina Gabanelli, Riccardo Riva, Patrizia Pinto, Ave Maria Biffi, Cristina Muscio
OBJECTIVE: To compare the diagnostic value of striatal (123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ((123) I-FP-CIT) single photon emission computed tomography (SPECT) and (123) I-metaiodobenzylguanidine ((123) I-MIBG) myocardial scintigraphy in differentiating dementia with Lewy bodies (DLB) from other dementia types. METHODS: This prospective longitudinal study included 30 patients with a clinical diagnosis of DLB and 29 patients with non-DLB dementia (Alzheimer disease, n = 16; behavioral variant frontotemporal dementia, n = 13)...
September 2016: Annals of Neurology
Carlos A Sánchez-Catasús, Gilles N Stormezand, Peter Jan van Laar, Peter P De Deyn, Mario Alvarez Sánchez, Rudi A J O Dierckx
This review article aims at providing a state-of-the-art review of the role of fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging (FDG-PET) in the prediction of Alzheimer's dementia in subjects suffering mild cognitive impairment (MCI), with a particular focus on the predictive power of FDG-PET compared to structural magnetic resonance imaging (sMRI). We also address perfusion single photon emission computed tomography (SPECT) as a less costly and more accessible alternative to FDG- PET. A search in PubMed was performed, taking into consideration relevant scientific articles published in English within the last five years and limited to human studies...
June 28, 2016: Current Alzheimer Research
Silvia Cascianelli, Michele Scialpi, Serena Amici, Nevio Forini, Matteo Minestrini, Mario Luca Fravolini, Helmut Sinzinger, Orazio Schillaci, Barbara Palumbo
Artificial Intelligence (AI) is a very active Computer Science research field aiming to develop systems that mimic human intelligence and is helpful in many human activities, including Medicine. In this review we presented some examples of the exploiting of AI techniques, in particular automatic classifiers such as Artificial Neural Network (ANN), Support Vector Machine (SVM), Classification Tree (ClT) and ensemble methods like Random Forest (RF), able to analyze findings obtained by positron emission tomography (PET) or single-photon emission tomography (SPECT) scans of patients with Neurodegenerative Diseases, in particular Alzheimer's Disease...
June 20, 2016: Current Alzheimer Research
M Reimold, C la Fougère
In neurodegeneration and in neuro-oncology, the standard imaging procedure, magnetic resonance imaging (MRI), shows limited sensitivity and specificity. Molecular imaging with specific positron-emission tomography (PET) and single-photon emission computed tomography (SPECT) tracers allows various molecular targets and metabolic processes to be assessed and is thus a valuable adjunct to MRI. Two important examples are referred to here: amino acid transport for neuro-oncological issues, and the recently approved PET tracers for detecting amyloid depositions during the preclinical stage of Alzheimer's disease...
July 2016: Der Radiologe
Tomomichi Iizuka, Masashi Kameyama
AIM: The brain region that shows reductions in regional cerebral blood flow (rCBF) earliest is the posterior cingulate cortex (PCC), which is thought to have a relationship with cognitive function. We made a hypothesis that the PCC hypoperfusion is a result of cholinergic dysfunction and can be restored by cholinergic enhancement. This present longitudinal study aimed to detect the restoration of PCC rCBF in response to donepezil, an acetylcholine esterase inhibitor. METHODS: We evaluated rCBF changes in the PCC, precuneus and anterior cingulate cortex using perfusion single-photon emission computed tomography (SPECT), statistical analysis and region of interest analysis, prospectively...
May 23, 2016: Geriatrics & Gerontology International
Guillaume Lamotte, Rémy Morello, Adrien Lebasnier, Denis Agostini, Gérard Bouvard, Vincent De La Sayette, Gilles L Defer
OBJECTIVES: Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are the two most common forms of dementia. These two diseases share some clinical and pathological similarities, yet the loss of dopaminergic neurons confirmed by 123-I-Ioflupane Single Photon Emission Computed Tomography (SPECT) is a suggestive feature of DLB. Current evidence suggests that higher education has a protective effect on the risk of developing clinical AD. However, how education influences cognitive performance and the presynaptic dopamine transporter marker in DLB is unknown...
July 2016: Clinical Neurology and Neurosurgery
Julie Deguil, Laura Ravasi, Yves Lamberty, Alexandra Auffret, Pierre Payoux, Christopher Leroy, Philippe Derambure, Régis Bordet
Pharmacological therapies currently marketed for Alzheimer's disease (AD) are only symptomatic and show limited effects in terms of clinical benefit. Thus, the development of new symptomatic drugs remains essential. However the dramatic increase in costs associated with drug development together with the poor number of emerging drugs highlights how crucial it is to accelerate the findings aiming to bringing new drugs to market. In this respect, optimization of the development process by integrating, at early stage, reliable biomarkers able to predict clinical benefit in phase III clinical trials may help...
2016: CNS & Neurological Disorders Drug Targets
Soichiro Shimizu, Hidekazu Kanetaka, Kentaro Hirao, Raita Fukasawa, Nayuta Namioka, Hirokuni Hatanaka, Daisuke Hirose, Takahiko Umahara, Hirofumi Sakurai, Haruo Hanyu
AIM: We compared the diagnostic value of four neuroimaging techniques, namely, (123) I-2β-Carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane ((123) I-FP-CIT) dopamine transporter single-photon emission computed tomography (DAT-SPECT), magnetic resonance imaging, perfusion SPECT and (123) I-metaiodobenzyl-guanidine myocardial scintigraphy in differentiating dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). METHODS: A total of 32 patients with probable AD and 32 patients with probable DLB were enrolled in the present study...
May 3, 2016: Geriatrics & Gerontology International
Tomomichi Iizuka, Masashi Kameyama
OBJECTIVE: The cingulate island sign (CIS), which refers to sparing of the posterior cingulate relative to the precuneus and cuneus, has been proposed as an FDG-PET imaging feature of dementia with Lewy bodies (DLB). The sign is reportedly associated with Alzheimer's disease (AD) type neurofibrillary tangle (NFT) pathology in autopsy cases. To confirm this relationship using neuroimaging modalities in vivo, we investigated associations between CIS and the medial temporal lobe (MTL) atrophy in DLB...
July 2016: Annals of Nuclear Medicine
Taku Yoshida, Takaaki Mori, Hideaki Shimizu, Yuta Yoshino, Naomi Sonobe, Teruhisa Matsumoto, Keiichi Kikuchi, Masao Miyagawa, Junichi Iga, Teruhito Mochizuki, Shu-Ichi Ueno
OBJECTIVE: Impairment of visual perception frequently occurs in Alzheimer's disease (AD) and can cause severe constraints in daily activities. The nonverbal Raven's Colored Progressive Matrices (RCPM) test consists of sets A, AB, and B and is easily performed in a short time to evaluate both visual perception and reasoning ability. The purpose of this study was to evaluate the neural basis of visual perception and reasoning ability in patients with AD using RCPM and single-photon emission computed tomography (SPECT)...
April 19, 2016: International Journal of Geriatric Psychiatry
D Salas-Gonzalez, F Segovia, F J Martínez-Murcia, E W Lang, J M Gorriz, J Ramırez
In this work, we present a fully automatic computer-aided diagnosis method for the early diagnosis of the Alzheimer's disease. We study the distance between classes (labelled as normal controls and possible Alzheimer's disease) calculated in 116 regions of the brain using the Welchs's t-test. We select the regions with highest Welchs's t-test value as features to perform classification. Furthermore, we also study the less discriminative region according to the t-test (regions with lowest t-test absolute values) in order to use them as reference...
2016: Current Alzheimer Research
Lieven D Declercq, Rik Vandenberghe, Koen Van Laere, Alfons Verbruggen, Guy Bormans
Clinical trials aiming to develop disease-altering drugs for Alzheimer's disease (AD), a neurodegenerative disorder with devastating consequences, are failing at an alarming rate. Poorly defined inclusion-and outcome criteria, due to a limited amount of objective biomarkers, is one of the major concerns. Non-invasive molecular imaging techniques, positron emission tomography and single photon emission (computed) tomography (PET and SPE(C)T), allow visualization and quantification of a wide variety of (patho)physiological processes and allow early (differential) diagnosis in many disorders...
2016: Frontiers in Pharmacology
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