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Palmoplantar pustulosis

Masamoto Murakami, Kenji Kameda, Hiroki Tsumoto, Teruko Tsuda, Kana Masuda, Ryo Utsunomiya, Hideki Mori, Yuri Miura, Koji Sayama
We previously reported that the early vesicle of the palmoplantar pustulosis (PPP) vesicle originated from eccrine sweat in the acrosyringium, and that the PPP vesicle contains the antimicrobial peptide human cathelicidin (hCAP)-18/LL-37. The concentration of LL-37 was sufficient to induce the subsequent inflammation in lesions and human keratinocytes, and the PPP vesicles contained additional small fragments of hCAP-18, of ∼7 kDa, which have not been identified. The aim of the present study was to clarify the additional processed forms found in PPP vesicles and their physiological effects on normal keratinocytes and sweat gland cells...
October 19, 2016: Journal of Investigative Dermatology
L Fenton, R S Dawe
BACKGROUND: In 2008, Ninewells Hospital became the first centre in the UK to offer grenz rays as a treatment for inflammatory dermatoses. Since then, 122 courses have been administered for the following conditions; scalp psoriasis (n = 36), nail dystrophies (n = 27), hyperkeratotic eczema/psoriasis (n = 22), palmoplantar pustulosis (n = 9), perianal pruritus (n = 9), warts (n = 4) and other conditions (n = 15). AIM: To review all patients who received grenz rays in order to determine which conditions have been treated successfully and to estimate remission times...
October 16, 2016: Clinical and Experimental Dermatology
Na Duan, Xiao Chen, Yongkang Liu, Jianhua Wang, Zhongqiu Wang
Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with sternoclavicular joint arthritis but without skin manifestations using multiple imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy. The first case was a 52-year-old male who suffered from progressive sternoclavicular arthritis for 2 years...
October 2016: Experimental and Therapeutic Medicine
Toshifumi Takahashi, Noriki Fujimoto, Miho Kabuto, Takeshi Nakanishi, Toshihiro Tanaka
Loss-of-function mutations of the IL36RN gene, encoding interleukin-36 receptor antagonist (IL-36Ra), have been reported as major pathogenic causes of generalized pustular psoriasis (GPP), especially in cases lacking previous histories of psoriasis vulgaris. Palmoplantar pustulosis (PPP), which is traditionally included among GPP-related diseases, has a controversial association with IL36RN. While a negative view about the said association has been recently published from Europe, variations of the IL36RN gene show great ethnic differences...
August 20, 2016: Journal of Dermatology
F Abadín López, E Revuelta Evrard
No abstract text is available yet for this article.
August 12, 2016: Semergen
M Misiak-Galazka, H Wolska, L Rudnicka
Palmoplantar pustulosis is characterized by a chronic eruption of sterile pustules on palms and soles. The disease affects mainly women in the sixth and seventh decade of life. Some authors consider palmoplantar pustulosis a separate entity, whereas others consider it a condition in the spectrum of psoriasis. Aim of this study was to summarize the most recent data about PPP which aimed at establishing the nosological position of palmoplantar pustulosis. A systematic search of published literature was carried out...
August 13, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Jung Eun Seol, In Ho Park, Wonkyung Lee, Hyojin Kim, So Young Jung, Han Young Wang
No abstract text is available yet for this article.
August 2016: Annals of Dermatology
Li-Na Su, Xin Xu, Li Tang, Ning Yu, Yang-Feng Ding
Palmoplantar pustulosis (PPP) is recalcitrant to traditional topical and systemic therapies. Ultraviolet A1 (UVA1) phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of PPP. The purpose of this study was to evaluate the efficacy and safety of UVA1 therapy for the treatment of PPP. Patients with PPP were treated with UVA1 irradiation three times a week for up to 30 sessions and had a 3-month follow-up visit. UVA1 therapy was conducted with a fixed dose (80 J/cm(2))...
November 2016: Lasers in Medical Science
José María Ortiz Salvador, Laura Cubells Sánchez, Daniela Subiabre Ferrer
No abstract text is available yet for this article.
July 15, 2016: Medicina Clínica
Jian-Wen Han, Yong Wang, Chulu Alateng, Hong-Bin Li, Yun-Hua Bai, Xin-Xiang Lyu, Rina Wu
BACKGROUND: Psoriasis is a common immune-mediated inflammatory dermatosis. Generalized pustular psoriasis (GPP) is the severe and rare type of psoriasis. The association between tumor necrosis factor-alpha induced protein 3 interacting protein 1 (TNIP1) gene and psoriasis was confirmed in people with multiple ethnicities. This study was to investigate the association between TNIP1 gene polymorphisms and pustular psoriasis in Chinese Han population. METHODS: Seventy-three patients with GPP, 67 patients with palmoplantar pustulosis (PPP), and 476 healthy controls were collected from Chinese Han population...
July 5, 2016: Chinese Medical Journal
Robert Bissonnette, Mayte Suárez-Fariñas, Xuan Li, Kathleen M Bonifacio, Carrie Brodmerkel, Judilyn Fuentes-Duculan, James G Krueger
[This corrects the article DOI: 10.1371/journal.pone.0155215.].
2016: PloS One
Petra Zimmermann, Nigel Curtis
SAPHO syndrome manifests as chronic inflammation of bones and joints, which may or may not be accompanied by skin changes. The term SAPHO is an acronym that stands for synovitis, acne, pustulosis (usually palmoplantar), hyperostosis and osteitis. The bones most commonly affected are those in the anterior chest wall (mainly the sternum, clavicles and sternocostoclavicular joints), the vertebrae and the sacroiliac joints, but peripheral and flat bones may also be involved, especially in children. There are no validated diagnostic criteria for SAPHO, and diagnosis is based on clinical and radiological findings...
July 5, 2016: Journal of Infection
P Weisenseel, D Wilsmann-Theis, C Kahl, K Reich, R Mössner
A number of pustular skin diseases share clinical, pathogenetic, and epidemiological aspects with plaque-type psoriasis, and their classification as a separate clinical entity or as a subtype of psoriasis remains controversial, which is also reflected in the multitude of their names. They include generalized pustular psoriasis with its subtypes, acrodermatitis continua suppurativa (Hallopeau), acute pustulosis palmopantaris, palmoplantar pustular psoriasis, and pustular variants of a mostly TNF-blocker triggered paradoxical psoriasiform dermatitis...
June 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Masato Ishizuka, Yuko Yamamoto, Shintaro Yamada, Sonoko Maemura, Ryo Nakata, Yoshihiro Motozawa, Keisuke Yamamoto, Masataka Takizawa, Hiroki Uozumi, Hiroshi Ikenouchi
A 79-year-old Asian man was hospitalized because of progressive exertional dyspnea with decreasing left ventricular ejection fraction and frequent non-sustained ventricular tachycardia. Pre-procedure venography for implantable cardioverter defibrillator (ICD) implantation showed occlusion of the bilateral subclavian veins. In consideration of subcutaneous humps in the sterno-clavicular area and palmoplantar pustulosis, we diagnosed him as having synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome and speculated that it induced peri-osteal chronic inflammation in the sterno-clavicular area, resulting in occlusion of the adjacent bilateral subclavian veins...
May 25, 2016: International Heart Journal
Robert Bissonnette, Mayte Suárez-Fariñas, Xuan Li, Kathleen M Bonifacio, Carrie Brodmerkel, Judilyn Fuentes-Duculan, James G Krueger
INTRODUCTION: There is a controversy surrounding the existence of palmoplantar pustulosis (PPP) and palmoplantar pustular psoriasis (PPPP) as separate clinical entities or as variants of the same clinical entity. We used gene expression microarray to compare gene expression in PPP and PPPP. METHODOLOGY/PRINCIPAL FINDINGS: Skin biopsies from subjects with PPP (3), PPPP (6), psoriasis vulgaris (10) and acral skin from normal subjects (7) were analyzed using gene expression microarray...
2016: PloS One
Megumi Mizawa, Teruhiko Makino, Chieko Inami, Tadamichi Shimizu
Palmoplantar pustulosis (PPP) is a chronic skin disease characterized by sterile intraepidermal pustules associated with erythematous scaling on the palms and soles. Jumihaidokuto is a traditional herbal medicine composed of ten medical plants and has been given to patients with suppurative skin disease in Japan. This study investigated the effect of jumihaidokuto on the disease activity in PPP patients (n = 10). PPP patients were given jumihaidokuto (EKT-6; 6.0 g per day) for 4 to 8 weeks in addition to their prescribed medications...
2016: Dermatology Research and Practice
Keiji Yamashita, Shingo Ichimiya, Ryuta Kamekura, Tomonori Nagaya, Sumito Jitsukawa, Hiroshi Matsumiya, Kenichi Takano, Tetsuo Himi
The tonsils are located at the entrance of the pharynx as a cardinal constituent of Waldeyer's ring, taking part not only in local immune responses, but also in systemic immunity. Functional deficits of tonsils primarily underlie the pathogenesis of various characteristic disorders, including tonsillar focal infections such as palmoplantar pustulosis and IgA nephropathy, in addition to the highly prevalent sleep disorder called obstructive sleep apnea syndrome. Although the mechanisms underlying these disorders remain unknown, the tonsils have long been postulated as a unique and enigmatic immune organ...
2016: Advances in Oto-rhino-laryngology
Inês Raposo, Tiago Torres
Palmoplantar psoriasis and palmoplantar pustulosis are chronic skin diseases with a large impact on patient quality of life. They are frequently refractory to treatment, being generally described as a therapeutic challenge. This article aims to review the definitions of palmoplantar psoriasis and palmoplantar pustulosis, highlighting the similarities and differences in terms of epidemiology, clinical presentation, genetics, histopathology, and pathogenesis, as well as treatment options for both entities. Classical management of mild to moderate palmoplantar pustulosis and palmoplantar psoriasis relies on use of potent topical corticosteroids, phototherapy, and/or acitretin...
August 2016: American Journal of Clinical Dermatology
Chen Li, Yuzhi Zuo, Nan Wu, Li Li, Feng Li, Weihong Zhang, Wenrui Xu, Xue Zhao, Hongli Jing, Qingqing Pan, Weixun Zhou, Xiaohua Shi, Yu Fan, Jianyi Wang, Sen Liu, Zhenlei Liu, Fengchun Zhang, Xiaofeng Zeng, Hui Chen, Siya Zhang, Jinhe Liu, Guixing Qiu, Zhihong Wu, Zhenhua Dong, Wen Zhang
OBJECTIVE: The aim was to assess the clinical, laboratory and radiological features of SAPHO syndrome. METHODS: We recruited all patients presenting to Peking Union Medical College Hospital from 2004 to 2015 diagnosed with SAPHO syndrome. The medical data, laboratory test results and imaging were collected for all patients. RESULTS: One hundred and sixty-four patients (111 women and 53 men) were recruited to our cohort. The mean age of the patients was 40...
June 2016: Rheumatology
D Timerman, P M Devlin, V E Nambudiri, N A Wright, R A Vleugels, R A Clark, T S Kupper, J F Merola, M Patel
Palmoplantar pustulosis (PPP) is a chronic pustular dermatitis of the palms and soles, which is frequently associated with significant pruritus and pain, often limiting daily activities. We present the case of a 36-year-old man with severe PPP who had treatment failure with multiple medical therapies but showed marked improvement with high-dose rate brachytherapy. Brachytherapy has the advantage of providing a conformal dose distribution over complex curved surfaces, such as the foot and ankle. Our observations suggest that brachytherapy may be a well-tolerated treatment option for patients with severe, refractory PPP...
July 2016: Clinical and Experimental Dermatology
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