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https://www.readbyqxmd.com/read/28527083/shared-mechanisms-of-epilepsy-migraine-and-affective-disorders
#1
Davide Zarcone, Simona Corbetta
Since the nineteenth century several clinical features have been observed in common between migraine and epilepsy (such as episodic attacks, triggering factors, presence of aura, frequent familiarity), but only in recent years researchers have really engaged in finding a common pathogenic mechanism. From studies of disease incidence, we understand how either migraine among patients with epilepsy or epilepsy among migraine patients are more frequent than in the general population. This association may result from a direct causality, by the same environmental risk factors and/or by a common genetic susceptibility...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28521762/clinical-experience-with-transcutaneous-supraorbital-nerve-stimulation-in-patients-with-refractory-migraine-or-with-migraine-and-intolerance-to-topiramate-a-prospective-exploratory-clinical-study
#2
Michail Vikelis, Emmanouil V Dermitzakis, Konstantinos C Spingos, Georgios G Vasiliadis, George S Vlachos, Evaggelia Kararizou
BACKGROUND: Migraine is included in the top-ten disabling diseases and conditions among the Western populations. Non-invasive neurostimulation, including the Cefaly® device, for the treatment of various types of pain is a relatively new field of interest. The aim of the present study was to explore the clinical experience with Cefaly® in a cohort of migraine patients previously refractory or intolerant to topiramate prophylaxis. METHODS: A prospective, multi-center clinical study was performed in patients diagnosed with episodic or chronic migraine with a previous failure to topiramate treatment requiring prevention with Cefaly® according to the treating physician's suggestion...
May 18, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28446038/clinical-criteria-of-positional-vertical-nystagmus-in-vestibular-migraine
#3
Mohamed Mohamed El-Badry, Hesham Samy, Abdel Mageed Kabel, Fatma Mohamed Rafat, Hossam Sanyelbhaa
OBJECTIVES: The goal of this study was to identify key diagnostic criteria for positional vertical nystagmus caused by vestibular migraine (VM). MATERIALS AND METHODS: The study group included a case series of 13 subjects with VM (10 females and three males with age 38.6 ± 8.9 years); they were complaining of positional vertigo. They were subjected to thorough audiovestibular examination and treated with cinnarizine or topiramate Results: The entire study group demonstrated positional vertical nystagmus (eight patients had up-beating nystagmus and five patients had down-beating nystagmus)...
April 27, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28428093/migraine-prevention-using-different-frequencies-of-transcutaneous-occipital-nerve-stimulation-a-randomized-controlled-trial
#4
Yinglu Liu, Zhao Dong, Rongfei Wang, Ran Ao, Xun Han, Wenjing Tang, Shengyuan Yu
OBJECTIVE: To evaluate the efficacy and tolerability of transcutaneous occipital nerve stimulation (tONS) in patients with migraine, and to explore whether different tONS frequencies influenced treatment effectiveness. METHODS: This was a randomized, controlled trial of tONS for prevention of migraine. Patients were randomized to one of five therapeutic groups prior to treatment for 1 month. Groups A-C received tONS at different frequencies (2 Hz, 100 Hz, and 2/100 Hz), group D underwent sham tONS intervention, and group E received topiramate orally...
April 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28424953/treatment-update-of-chronic-migraine
#5
REVIEW
Soo-Jin Cho, Tae-Jin Song, Min Kyung Chu
PURPOSE OF REVIEW: Although chronic migraine (CM) is a common disorder that severely impacts patient functioning and quality of life, it is usually underdiagnosed, and treatment responses often remain poor even after diagnosis. In addition, effective treatment options are limited due to the rarity of randomized controlled trials (RCTs) involving patients with CM. In the present review, we discuss updated pharmacological, non-pharmacological, and neurostimulation treatment options for CM...
June 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28405886/pharmacokinetic-variability-of-drugs-used-for-prophylactic-treatment-of-migraine
#6
REVIEW
Peer Tfelt-Hansen, Frederik Nybye Ågesen, Agniezka Pavbro, Jacob Tfelt-Hansen
In this review, we evaluate the variability in the pharmacokinetics of 11 drugs with established prophylactic effects in migraine to facilitate 'personalized medicine' with these drugs. PubMed was searched for 'single-dose' and 'steady-state' pharmacokinetic studies of these 11 drugs. The maximum plasma concentration was reported in 248 single-dose and 115 steady-state pharmacokinetic studies, and the area under the plasma concentration-time curve was reported in 299 single-dose studies and 112 steady-state pharmacokinetic studies...
May 2017: CNS Drugs
https://www.readbyqxmd.com/read/28387107/-bilateral-angle-closure-glaucoma-induced-by-topiramate
#7
O Beaudry, V Goncette, N Collignon
Topiramate (TPM) is a drug used in migraine prophylaxis. It is involved in the bilateral angle-closure glaucoma due to idiosyncratic response. This side effect is rare but can lead to irreversible vision loss if it is not recognized in time and if it is not managed immediately by an ophthalmologist.
November 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28351170/effect-of-topiramate-on-choroidal-thickness-and-anterior-chamber-parameters-in-the-treatment-of-patients-with-migraine
#8
Mustafa Gok, Ozdemir Ozdemir
OBJECTIVE: To investigate the effects of topiramate on choroidal thickness and anterior chamber parameters using optical coherence tomography in the treatment of patients with migraine. METHODS: A total of 22 eyes of 22 adults (12 females, 10 males) diagnosed with migraine and scheduled to topiramate treatment for pain control were recruited in this prospective study. Choroidal thickness (CT), anterior chamber depth (ACD), anterior chamber angle (ACA), spherical refractive equivalent (SphEq) and intraocular pressure (IOP) measurements were recorded at baseline (prior the topiramate therapy), first and second month visits for the statistical analysis...
April 19, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28329903/-headache-treatment
#9
REVIEW
Hans Christoph Diener, Dagny Holle-Lee, Steffen Nägel, Charly Gaul
A precondition for the successful treatment of headaches is the correct headache diagnosis. Triptans are effective for attack treatment of migraine and cluster headache. However, there are not effective for the treatment of tension-type headache. For the prevention of frequent episodic migraine betablockers, flunarizine, topiramate and amitriptyline are recommended. For the prevention of chronic migraine evidence is only available for onabotulinumtoxinA and topiramate. For prophylactic treatment of tension-type headaches tricyclic antidepressants are used...
March 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28246124/amitriptyline-and-topiramate-are-no-better-than-placebo-for-childhood-migraine
#10
Rebecca A Dalrymple, Ian Wacogne
No abstract text is available yet for this article.
February 28, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28237143/topiramate-and-accommodation-does-topiramate-cause-accommodative-dysfunction
#11
Eren Çerman, Semra Akkaya Turhan, Muhsin Eraslan, Pınar Kahraman Koytak, Özden Kilinç, Tülin Tanrıdağ
OBJECTIVE: To investigate the accommodation function in topiramate users. DESIGN: Case-control clinical study. PARTICIPANTS: The participants included 16 controls and 22 patients using 100 mg/kg topiramate who were diagnosed with migraine according to the International Classification of Headache Disorders, second edition criteria. METHODS: One-minute dynamic measurements of refraction with accommodation stimuli of 0 D, 2 D, 2...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28220376/unveiling-the-relative-efficacy-safety-and-tolerability-of-prophylactic-medications-for-migraine-pairwise-and-network-meta-analysis
#12
Aijie He, Dehua Song, Lei Zhang, Chen Li
BACKGROUND: A large number patients struggle with migraine which is classified as a chronic disorder. The relative efficacy, safety and tolerability of prophylactic medications for migraine play a key role in managing this disease. METHODS: We conducted an extensive literature search for popular prophylactic medications that are used for migraine patients. Pairwise meta-analysis and network meta-analysis (NMA) were carried out sequentially for determining the relative efficacy, safety and tolerability of prophylactic medications...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28150096/preventive-drugs-restore-visual-evoked-habituation-and-attention-in-migraineurs
#13
Ferda Ince, Emel Erdogan-Bakar, Isin Unal-Cevik
Visual system pathway dysfunction has been postulated in migraineurs. We wanted to investigate if any difference exists interictally in visual attention and visual evoked habituation of frequently attacked migraineurs compared to the healthy control group. The effects of 3-month prophylactic migraine treatment on these parameters were also assessed. The migraineurs at headache-free interval (n = 52) and age, sex-matched healthy controls (n = 35) were compared by habituation response to 10 blocks of repetitive pattern-reversal visual stimuli (each block consisted 100 responses)...
February 1, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28034861/dtb-select-1-january-2017
#14
(no author information available yet)
Brimonidine gel: risk of exacerbation of rosacea ● Metformin for patients with moderately reduced kidney function ● Effect of an optimal cranberry dose on bacteriuria ● Amitriptyline and topiramate ineffective for paediatric migraine prophylaxis ● Etoricoxib: 60mg dose for RA and ankylosing spondylitis ● CRP and diagnosis of CAP ● International travel and antimicrobial resistance ● Effect of telemedicine on diabetes control.
January 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27957623/real-life-data-in-115-chronic-migraine-patients-treated-with-onabotulinumtoxin-a-during-more-than-one-year
#15
MULTICENTER STUDY
I Aicua-Rapun, E Martínez-Velasco, A Rojo, A Hernando, M Ruiz, A Carreres, E Porqueres, S Herrero, F Iglesias, A L Guerrero
BACKGROUND: OnabotulinumtoxinA (OnabotA) is effective in Chronic Migraine (CM) during first year of treatment and longer. In real clinical setting, CM patients with acute Medication Overuse (MO) or concurrently receiving oral preventatives are treated with OnabotA. We aim to assess evolution of CM patients beyond first year on OnabotA. METHODS: Data were retrospectively collected in three headache units. We analyzed cases who had received at least five sessions of OnabotA according to PREEMPT protocol...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27956547/antiepileptic-drugs-in-migraine-and-epilepsy-who-is-at-increased-risk-of-adverse-events
#16
Michele Romoli, Cinzia Costa, Sabrina Siliquini, Ilenia Corbelli, Paolo Eusebi, Chiara Bedetti, Stefano Caproni, Letizia Maria Cupini, Paolo Calabresi, Paola Sarchielli
BACKGROUND: The impact of adverse events (AEs) of antiepileptic drugs (AEDs) have an impact on compliance and dropouts. We compared tolerability of AEs of AEDs among patients with migraine, epilepsy, or both. METHODS: Overall, 335 patients (epilepsy (n = 142), migraine (n = 131), and both (n = 62)), were evaluated with the Liverpool Adverse Events Profile (LAEP) to assess the magnitude, profile and occurrence rate of the AEs of valproate, topiramate, and lamotrigine...
December 12, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919769/transcriptomic-changes-in-rat-cortex-and-brainstem-after-cortical-spreading-depression-with-or-without-pretreatment-with-migraine-prophylactic-drugs
#17
Cèlia Sintas, Noèlia Fernàndez-Castillo, Marta Vila-Pueyo, Patricia Pozo-Rosich, Alfons Macaya, Bru Cormand
Migraine with aura is a subtype of migraine characterized by transient neurological disturbances that usually precede headache. Cortical spreading depression (CSD) is the likely pathophysiological correlate of the aura phase of migraine, found in common and rare forms of migraine, such as familial hemiplegic migraine. CSD is a depolarization wave that propagates across the cerebral gray matter transiently suppressing neuronal activity. Prophylactic treatments for migraine, such as topiramate or valproate, reduce the number of CSD events...
December 3, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27910097/chronic-migraine-an-update-on-physiology-imaging-and-the-mechanism-of-action-of-two-available-pharmacologic-therapies
#18
Sheena K Aurora, Mitchell F Brin
Several lines of research support the hypothesis that migraine is a spectrum of illness, with clinical symptoms that vary along a continuum from episodic migraine to chronic migraine. Physiologic changes may result in episodic migraine evolving into chronic migraine over months to years in susceptible individuals. With chronification, headache frequency increases, becoming more disabling and less responsive to therapy. Neurophysiologic and functional imaging research has reported that chronic migraine may be associated with severity-specific metabolic, functional, and structural abnormalities in the brainstem...
January 2017: Headache
https://www.readbyqxmd.com/read/27910087/menstrual-migraine-and-treatment-options-review
#19
REVIEW
Kasra Maasumi, Stewart J Tepper, Jennifer S Kriegler
OBJECTIVE: A review of treatment options for menstrual migraine. BACKGROUND: Migraine affects ∼30 million people in the US. A subset of female migraineurs have migraines that are mainly associated with menstruation. Menstrual migraine (MM) is divided into pure MM and menstrually related migraine. Pure MM attacks occur only with menstruation and have a prevalence of 1%. Menstrually related migraine has a prevalence of 6-7%, and occurs both during menstruation as well as during the rest of the cycle...
February 2017: Headache
https://www.readbyqxmd.com/read/27902848/topiramate-in-migraine-prevention-a-2016-perspective
#20
Stephen D Silberstein
BACKGROUND: In evidence-based guidelines published in 2000, topiramate was a third-tier migraine preventive with no scientific evidence of efficacy; recommendation for its use reflected consensus opinion and clinical experience. Its neurostabilizing activity, coupled with its favorable weight profile, made topiramate an attractive alternative to other migraine preventives that caused weight gain. When guidelines for migraine prevention in episodic migraine were published in 2012, topiramate was included as a first-line option based on double-blind, randomized controlled trials involving nearly 3000 patients...
January 2017: Headache
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