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https://www.readbyqxmd.com/read/29083407/exome-chip-meta-analysis-identifies-novel-loci-and-east-asian-specific-coding-variants-that-contribute-to-lipid-levels-and-coronary-artery-disease
#1
Xiangfeng Lu, Gina M Peloso, Dajiang J Liu, Ying Wu, He Zhang, Wei Zhou, Jun Li, Clara Sze-Man Tang, Rajkumar Dorajoo, Huaixing Li, Jirong Long, Xiuqing Guo, Ming Xu, Cassandra N Spracklen, Yang Chen, Xuezhen Liu, Yan Zhang, Chiea Chuen Khor, Jianjun Liu, Liang Sun, Laiyuan Wang, Yu-Tang Gao, Yao Hu, Kuai Yu, Yiqin Wang, Chloe Yu Yan Cheung, Feijie Wang, Jianfeng Huang, Qiao Fan, Qiuyin Cai, Shufeng Chen, Jinxiu Shi, Xueli Yang, Wanting Zhao, Wayne H-H Sheu, Stacey Shawn Cherny, Meian He, Alan B Feranil, Linda S Adair, Penny Gordon-Larsen, Shufa Du, Rohit Varma, Yii-Der Ida Chen, Xiao-Ou Shu, Karen Siu Ling Lam, Tien Yin Wong, Santhi K Ganesh, Zengnan Mo, Kristian Hveem, Lars G Fritsche, Jonas Bille Nielsen, Hung-Fat Tse, Yong Huo, Ching-Yu Cheng, Y Eugene Chen, Wei Zheng, E Shyong Tai, Wei Gao, Xu Lin, Wei Huang, Goncalo Abecasis, Sekar Kathiresan, Karen L Mohlke, Tangchun Wu, Pak Chung Sham, Dongfeng Gu, Cristen J Willer
Most genome-wide association studies have been of European individuals, even though most genetic variation in humans is seen only in non-European samples. To search for novel loci associated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci, we used an exome array to examine protein-coding genetic variants in 47,532 East Asian individuals. We identified 255 variants at 41 loci that reached chip-wide significance, including 3 novel loci and 14 East Asian-specific coding variant associations...
October 30, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28585973/impact-on-short-lived-climate-forcers-slcfs-from-a-realistic-land-use-change-scenario-via-changes-in-biogenic-emissions
#2
C E Scott, S A Monks, D V Spracklen, S R Arnold, P M Forster, A Rap, K S Carslaw, M P Chipperfield, C L S Reddington, C Wilson
More than one quarter of natural forests have been cleared by humans to make way for other land-uses, with changes to forest cover projected to continue. The climate impact of land-use change (LUC) is dependent upon the relative strength of several biogeophysical and biogeochemical effects. In addition to affecting the surface albedo and exchanging carbon dioxide (CO2) and moisture with the atmosphere, vegetation emits biogenic volatile organic compounds (BVOCs), altering the formation of short-lived climate forcers (SLCFs) including aerosol, ozone (O3) and methane (CH4)...
August 24, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28334899/association-analyses-of-east-asian-individuals-and-trans-ancestry-analyses-with-european-individuals-reveal-new-loci-associated-with-cholesterol-and-triglyceride-levels
#3
Cassandra N Spracklen, Peng Chen, Young Jin Kim, Xu Wang, Hui Cai, Shengxu Li, Jirong Long, Ying Wu, Ya Xing Wang, Fumihiko Takeuchi, Jer-Yuarn Wu, Keum-Ji Jung, Cheng Hu, Koichi Akiyama, Yonghong Zhang, Sanghoon Moon, Todd A Johnson, Huaixing Li, Rajkumar Dorajoo, Meian He, Maren E Cannon, Tamara S Roman, Elias Salfati, Keng-Hung Lin, Xiuqing Guo, Wayne H H Sheu, Devin Absher, Linda S Adair, Themistocles L Assimes, Tin Aung, Qiuyin Cai, Li-Ching Chang, Chien-Hsiun Chen, Li-Hsin Chien, Lee-Ming Chuang, Shu-Chun Chuang, Shufa Du, Qiao Fan, Cathy S J Fann, Alan B Feranil, Yechiel Friedlander, Penny Gordon-Larsen, Dongfeng Gu, Lixuan Gui, Zhirong Guo, Chew-Kiat Heng, James Hixson, Xuhong Hou, Chao Agnes Hsiung, Yao Hu, Mi Yeong Hwang, Chii-Min Hwu, Masato Isono, Jyh-Ming Jimmy Juang, Chiea-Chuen Khor, Yun Kyoung Kim, Woon-Puay Koh, Michiaki Kubo, I-Te Lee, Sun-Ju Lee, Wen-Jane Lee, Kae-Woei Liang, Blanche Lim, Sing-Hui Lim, Jianjun Liu, Toru Nabika, Wen-Harn Pan, Hao Peng, Thomas Quertermous, Charumathi Sabanayagam, Kevin Sandow, Jinxiu Shi, Liang Sun, Pok Chien Tan, Shu-Pei Tan, Kent D Taylor, Yik-Ying Teo, Sue-Anne Toh, Tatsuhiko Tsunoda, Rob M van Dam, Aili Wang, Feijie Wang, Jie Wang, Wen Bin Wei, Yong-Bing Xiang, Jie Yao, Jian-Min Yuan, Rong Zhang, Wanting Zhao, Yii-Der Ida Chen, Stephen S Rich, Jerome I Rotter, Tzung-Dau Wang, Tangchun Wu, Xu Lin, Bok-Ghee Han, Toshihiro Tanaka, Yoon Shin Cho, Tomohiro Katsuya, Weiping Jia, Sun-Ha Jee, Yuan-Tsong Chen, Norihiro Kato, Jost B Jonas, Ching-Yu Cheng, Xiao-Ou Shu, Jiang He, Wei Zheng, Tien-Yin Wong, Wei Huang, Bong-Jo Kim, E-Shyong Tai, Karen L Mohlke, Xueling Sim
Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). With differences in linkage disequilibrium (LD) structure and allele frequencies between ancestry groups, studies in additional large samples may detect new associations. We conducted staged GWAS meta-analyses in up to 69,414 East Asian individuals from 24 studies with participants from Japan, the Philippines, Korea, China, Singapore, and Taiwan...
May 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28051060/experimental-observation-of-anomalous-topological-edge-modes-in-a-slowly-driven-photonic-lattice
#4
Sebabrata Mukherjee, Alexander Spracklen, Manuel Valiente, Erika Andersson, Patrik Öhberg, Nathan Goldman, Robert R Thomson
Topological quantum matter can be realized by subjecting engineered systems to time-periodic modulations. In analogy with static systems, periodically driven quantum matter can be topologically classified by topological invariants, whose non-zero value guarantees the presence of robust edge modes. In the high-frequency limit of the drive, topology is described by standard topological invariants, such as Chern numbers. Away from this limit, these topological numbers become irrelevant, and novel topological invariants must be introduced to capture topological edge transport...
January 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/27848989/population-exposure-to-hazardous-air-quality-due-to-the-2015-fires-in-equatorial-asia
#5
P Crippa, S Castruccio, S Archer-Nicholls, G B Lebron, M Kuwata, A Thota, S Sumin, E Butt, C Wiedinmyer, D V Spracklen
Vegetation and peatland fires cause poor air quality and thousands of premature deaths across densely populated regions in Equatorial Asia. Strong El-Niño and positive Indian Ocean Dipole conditions are associated with an increase in the frequency and intensity of wildfires in Indonesia and Borneo, enhancing population exposure to hazardous concentrations of smoke and air pollutants. Here we investigate the impact on air quality and population exposure of wildfires in Equatorial Asia during Fall 2015, which were the largest over the past two decades...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27773953/small-global-effect-on-terrestrial-net-primary-production-due-to-increased-fossil-fuel-aerosol-emissions-from-east-asia-since-the-turn-of-the-century
#6
M O'Sullivan, A Rap, C L Reddington, D V Spracklen, M Gloor, W Buermann
The global terrestrial carbon sink has increased since the start of this century at a time of growing carbon emissions from fossil fuel burning. Here we test the hypothesis that increases in atmospheric aerosols from fossil fuel burning enhanced the diffuse light fraction and the efficiency of plant carbon uptake. Using a combination of models, we estimate that at global scale changes in light regimes from fossil fuel aerosol emissions had only a small negative effect on the increase in terrestrial net primary production over the period 1998-2010...
August 16, 2016: Geophysical Research Letters
https://www.readbyqxmd.com/read/27457817/promoter-region-variation-in-nfe2l2-influences-susceptibility-to-ototoxicity-in-patients-exposed-to-high-cumulative-doses-of-cisplatin
#7
T F Spracklen, A A Vorster, L Ramma, S Dalvie, R S Ramesar
Ototoxicity is a disabling reaction to cisplatin chemotherapy. Much of the inter-individual variability in the development of hearing impairment among cisplatin-receiving patients has not been fully accounted for. In particular, little is known about the pharmacogenomics of cisplatin-induced ototoxicity. This study sought to investigate the role of variation in five candidate genes in a cohort of South African cancer patients. Five variants within the candidate genes were genotyped in 214 patients, of which SLC22A2 rs316019 and NFE2L2 rs6721961 associated with reduced rates of ototoxicity...
July 26, 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/27440911/low-birth-weight-and-risk-of-later-life-physical-disability-in-women
#8
Cassandra N Spracklen, Kelli K Ryckman, Jennifer G Robinson, Marcia L Stefanick, Gloria E Sarto, Stephen D Anton, Robert B Wallace
Background: There is strong evidence that low and high birth weight due to in-utero programming results in elevated risk for adult diseases, though less research has been performed examining the influence of birth weight and physical disability later in life. Methods: Baseline data from 76,055 postmenopausal women in the Women's Health Initiative, a large multi-ethnic cohort, were used to examine the association between self-reported birth weight category (<6 lbs, 6-7 lbs 15 oz, 8-9 lbs 15 oz, and ≥10 lbs) and the self-reported physical functioning score on the RAND 36-item Health Survey...
April 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27385341/abelson-kinase-acts-as-a-robust-multifunctional-scaffold-in-regulating-embryonic-morphogenesis
#9
Edward M Rogers, Andrew J Spracklen, Colleen G Bilancia, Kaelyn D Sumigray, S Colby Allred, Stephanie H Nowotarski, Kristina N Schaefer, Benjamin J Ritchie, Mark Peifer
Abelson family kinases (Abls) are key regulators of cell behavior and the cytoskeleton during development and in leukemia. Abl's SH3, SH2, and tyrosine kinase domains are joined via a linker to an F-actin-binding domain (FABD). Research on Abl's roles in cell culture led to several hypotheses for its mechanism of action: 1) Abl phosphorylates other proteins, modulating their activity, 2) Abl directly regulates the cytoskeleton via its cytoskeletal interaction domains, and/or 3) Abl is a scaffold for a signaling complex...
August 15, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/26983534/global-warming-china-s-contribution-to-climate-change
#10
COMMENT
Dominick V Spracklen
No abstract text is available yet for this article.
March 17, 2016: Nature
https://www.readbyqxmd.com/read/26956568/intimate-partner-violence-during-pregnancy-and-the-risk-for-adverse-infant-outcomes-a-systematic-review-and-meta-analysis
#11
REVIEW
B M Donovan, C N Spracklen, M L Schweizer, K K Ryckman, A F Saftlas
BACKGROUND: Intimate partner violence (IPV) is of particular concern during pregnancy when not one, but two lives are at risk. Previous meta-analyses have suggested an association between IPV and adverse birth outcomes; however, many large studies have since been published, illustrating the need for updated pooled effect estimates. OBJECTIVES: To evaluate the relationship between IPV during pregnancy and the risk of preterm birth (PTB), low-birthweight (LBW), and small-for-gestational-age (SGA) infants...
July 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/26910608/physical-activity-during-pregnancy-and-subsequent-risk-of-preeclampsia-and-gestational-hypertension-a-case-control-study
#12
Cassandra N Spracklen, Kelli K Ryckman, Elizabeth W Triche, Audrey F Saftlas
OBJECTIVE: Physical activity (PA) is hypothesized to reduce the risk of preeclampsia, but few epidemiologic studies have simultaneously evaluated leisure time PA (LTPA), sedentary activity, occupational activity, and non-occupational, non-leisure time PA. Thus, we assessed the independent and combined effects of these different types of PA during pregnancy on preeclampsia and gestational hypertension risk. METHODS: Preeclamptic (n = 258), gestational hypertensive (n = 233), and normotensive (n = 182) women identified from Iowa live birth records (2002-2005) were participants in Study of Pregnancy Hypertension in Iowa...
June 2016: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/26632842/a-global-analysis-of-deforestation-in-moist-tropical-forest-protected-areas
#13
B D Spracklen, M Kalamandeen, D Galbraith, E Gloor, D V Spracklen
Protected areas (PAs) have been established to conserve tropical forests, but their effectiveness at reducing deforestation is uncertain. To explore this issue, we combined high resolution data of global forest loss over the period 2000-2012 with data on PAs. For each PA we quantified forest loss within the PA, in buffer zones 1, 5, 10 and 15 km outside the PA boundary as well as a 1 km buffer within the PA boundary. We analysed 3376 tropical and subtropical moist forest PAs in 56 countries over 4 continents...
2015: PloS One
https://www.readbyqxmd.com/read/26196987/observation-of-a-localized-flat-band-state-in-a-photonic-lieb-lattice
#14
Sebabrata Mukherjee, Alexander Spracklen, Debaditya Choudhury, Nathan Goldman, Patrik Öhberg, Erika Andersson, Robert R Thomson
We demonstrate the first experimental realization of a dispersionless state, in a photonic Lieb lattice formed by an array of optical waveguides. This engineered lattice supports three energy bands, including a perfectly flat middle band with an infinite effective mass. We analyze, both experimentally and theoretically, the evolution of well-prepared flat-band states, and show their remarkable robustness, even in the presence of disorder. The realization of flat-band states in photonic lattices opens an exciting door towards quantum simulation of flat-band models in a highly controllable environment...
June 19, 2015: Physical Review Letters
https://www.readbyqxmd.com/read/26002928/genetic-risk-score-for-essential-hypertension-and-risk-of-preeclampsia
#15
MULTICENTER STUDY
Caitlin J Smith, Audrey F Saftlas, Cassandra N Spracklen, Elizabeth W Triche, Andrew Bjonnes, Brendan Keating, Richa Saxena, Patrick J Breheny, Andrew T Dewan, Jennifer G Robinson, Josephine Hoh, Kelli K Ryckman
BACKGROUND: Preeclampsia is a hypertensive complication of pregnancy characterized by novel onset of hypertension after 20 weeks gestation, accompanied by proteinuria. Epidemiological evidence suggests that genetic susceptibility exists for preeclampsia; however, whether preeclampsia is the result of underlying genetic risk for essential hypertension has yet to be investigated. Based on the hypertensive state that is characteristic of preeclampsia, we aimed to determine if established genetic risk scores (GRSs) for hypertension and blood pressure are associated with preeclampsia...
January 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/25839909/land-use-change-impacts-on-air-quality-and-climate
#16
Colette L Heald, Dominick V Spracklen
No abstract text is available yet for this article.
May 27, 2015: Chemical Reviews
https://www.readbyqxmd.com/read/25835577/a-retrospective-study-of-administration-of-vaccination-for-hepatitis-b-among-newborn-infants-prior-to-hospital-discharge-at-a-midwestern-tertiary-care-center
#17
Helen I Myers, Cassandra N Spracklen, Kelli K Ryckman, Jeffrey C Murray
OBJECTIVES: Infants are at high risk of developing chronic, life-threatening disease as a result of hepatitis B virus infection. Universal vaccination of infants against hepatitis B virus, before discharge from the hospital after delivery is recommended as a measure to eradicate infection and associated mortality and morbidity. The purpose of this study was to determine rates of perinatal hepatitis B vaccine (Hep B) administration at a tertiary care center in Iowa and to assess the impact of maternal factors on Hep B uptake...
May 11, 2015: Vaccine
https://www.readbyqxmd.com/read/25721621/influence-of-a-loop-electrosurgical-excision-procedure-leep-on-levels-of-cytokines-in-cervical-secretions
#18
Audrey F Saftlas, Cassandra N Spracklen, Kelli K Ryckman, Colleen K Stockdale, Kerri Penrose, Kevin Ault, Linda M Rubenstein, Ligia A Pinto
Over the past decade, there has been heightened interest in determining if there is an increased risk of adverse reproductive outcomes among women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN). The objective of this exploratory study was to determine if the treatment of CIN with a LEEP is associated with changes in cervical soluble immune markers. Cervical cytokine concentrations were measured in women treated with LEEP and a control group of women who had colposcopy only and did not undergo LEEP...
June 2015: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/25612005/maternal-lipid-levels-during-pregnancy-and-gestational-diabetes-a-systematic-review-and-meta-analysis
#19
REVIEW
K K Ryckman, C N Spracklen, C J Smith, J G Robinson, A F Saftlas
BACKGROUND: Lipid levels during pregnancy in women with gestational diabetes mellitus (GDM) have been extensively studied; however, it remains unclear whether dyslipidaemia is a potential marker of preexisting insulin resistance. OBJECTIVE: To evaluate the relationship between lipid measures throughout pregnancy and GDM. SEARCH STRATEGY: We searched PubMed-MedLine and SCOPUS (inception until January 2014) and reference lists of relevant studies...
April 2015: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/25523295/genetic-predisposition-to-dyslipidemia-and-risk-of-preeclampsia
#20
Cassandra N Spracklen, Audrey F Saftlas, Elizabeth W Triche, Andrew Bjonnes, Brendan Keating, Richa Saxena, Patrick J Breheny, Andrew T Dewan, Jennifer G Robinson, Josephine Hoh, Kelli K Ryckman
BACKGROUND: Large epidemiologic studies support the role of dyslipidemia in preeclampsia; however, the etiology of preeclampsia or whether dyslipidemia plays a causal role remains unclear. We examined the association between the genetic predisposition to dyslipidemia and risk of preeclampsia using validated genetic markers of dyslipidemia. METHODS: Preeclampsia cases (n = 164) and normotensive controls (n = 110) were selected from live birth certificates to nulliparous Iowa women during the period August 2002 to May 2005...
July 2015: American Journal of Hypertension
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