Read by QxMD icon Read

Disk Degeneration

Moustafa N Aboushelib, Hala Ragab, Mohamed Arnaot
PURPOSE: To evaluate the influence of different aging techniques on zirconia-composite microtensile bond strength using different surface treatments over a 5-year follow-up period. MATERIALS AND METHODS: Zirconia disks received three surface treatments: airborne-particle abrasion with 50-μm aluminum oxide particles, selective infiltration etching (SIE), or fusion sputtering (FS). The specimens were bonded to pre-aged composite disks using a composite cement containing phosphate monomers (Panavia F2...
2018: Journal of Adhesive Dentistry
Xianda Gao, Linfeng Wang, Jingtao Zhang, Peng Wang, Yong Shen
STUDY DESIGN: This is retrospective study. OBJECTIVE: Our purpose is to examine the state of the L5-S1 disk after long fusion arthrodesis stopping at L5 in adult scoliosis, and to identify the risk factors for disk degeneration. SUMMARY OF BACKGROUND DATA: The long fusion arthrodesis surgery for adult scoliosis has shown to have good clinical results. However, there is still some controversy with reference to the potential caudal extents of the fusion, that is, L5 or S1...
March 2, 2018: Clinical Spine Surgery
Peter Trampus, Christine Goepfert, Monika Welle, Diana Henke, Franck Forterre, Daniela Schweizer-Gorgas
Muscle signal alteration detected on MRI is seen in diverse pathologic conditions. We observed signal alterations within the paraspinal muscles in dogs with acute thoracolumbar intervertebral disk extrusion. The aim of this retrospective study was to describe MRI features of paraspinal muscle signal alteration in dogs with acute thoracolumbar intervertebral disk extrusion and to investigate an association of the signal alterations with neurological grade, type and location of intervertebral disk extrusion, degree of spinal cord compression, and presence of epidural hemorrhage...
2018: Frontiers in Veterinary Science
Wei Guo, Bin Zhang, Kun Mu, Shi-Qing Feng, Zhan-Yin Dong, Guang-Zhi Ning, Hao-Ran Li, Shen Liu, Ling Zhao, Yan Li, Bing-Bing Yu, Hui-Quan Duan, Chao Sun, Yong-Jin Li
Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. In conclusion, the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD...
February 23, 2018: Cell Death & Disease
M C Sánchez-Migallón, F J Valiente-Soriano, M Salinas-Navarro, F M Nadal-Nicolás, M Jiménez-López, M Vidal-Sanz, M Agudo-Barriuso
We have investigated the long term effects of two different models of unilateral optic nerve (ON) lesion on retinal ganglion cells (RGCs) and their axons, in the injured and contralateral retinas of adult albino mice. Intact animals were used as controls. The left ON was intraorbitally crushed or transected at 0.5 mm from the optic disk and both retinas were analyzed at 2, 3, 5, 7, 14, 30, 45 or 90 days after injury. RGCs were immunoidentified with anti-Brn3a, and their axons with anti-highly phosphorylated axonal neurofilament subunit H (pNFH)...
February 13, 2018: Experimental Eye Research
Sascha Hopp, Ishaq Ojodu, Atul Jain, Tobias Fritz, Tim Pohlemann, Jens Kelm
INTRODUCTION: Radiographic abnormalities of the symphysis as well as the formation of accessory clefts, indicating injury at the rectus-adductor aponeurosis, reportedly relate to longstanding groin pain in athletes. However, yet, no systematic classification for clinical and scientific purposes exists. We aimed to (1) create a radiographic classification based on symphysography; (2) test intra- and interobserver reliability; (3) characterise clinical significance of the morphologic patterns by evaluating success of injection therapy...
February 7, 2018: Archives of Orthopaedic and Trauma Surgery
A Schänzer, S Rupp, S Gräf, D Zengeler, C Jux, H Akintürk, L Gulatz, N Mazhari, T Acker, R Van Coster, B K Garvalov, A Hahn
Myofibrillary myopathies (MFM) are hereditary myopathies histologically characterized by degeneration of myofibrils and aggregation of proteins in striated muscle. Cardiomyopathy is common in MFM but the pathophysiological mechanisms are not well understood. The BAG3-Pro209Leu mutation is associated with early onset MFM and severe restrictive cardiomyopathy (RCM), often necessitating heart transplantation during childhood. We report on a young male patient with a BAG3-Pro209Leu mutation who underwent heart transplantation at eight years of age...
January 6, 2018: Molecular Genetics and Metabolism
William R McGehee, Thomas Michels, Vladimir Aksyuk, Jabez J McClelland
High-resolution imaging of optical resonator modes is a key step in the development and characterization of nanophotonic devices. Many sub-wavelength mode-imaging techniques have been developed using optical and electron beam excitation-each with its own limitations in spectral and spatial resolution. Here, we report a 2D imaging technique using a pulsed, low-energy focused ion beam of Li+ to probe the near-surface fields inside photonic resonators. The ion beam locally modifies the resonator structure, causing temporally varying spectroscopic shifts of the resonator...
November 2017: Optica
Timothy T Roberts, Ryan J Filler, Jason W Savage, Edward C Benzel
In the United States, cervical total disk arthroplasty (TDA) is US Federal Drug Administration (FDA) approved for use in both 1 and 2-level constructions for cervical disk disease resulting in myelopathy and/or radiculopathy. TDA designs vary in form, function, material composition, and even performance in vivo. However, the therapeutic goals are the same: to remove the painful degenerative/damaged elements of the intervertebral discoligamenous joint complex, to preserve or restore the natural range of spinal motion, and to mitigate stresses on adjacent spinal segments, thereby theoretically limiting adjacent segment disease (ASDis)...
January 8, 2018: Clinical Spine Surgery
Kittipong Sessumpun, Permsak Paholpak, Kevork N Hindoyan, Koji Tamai, Thananit Sangkomkamhang, Zorica Buser, Jeffrey C Wang
STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate how each type of sagittal cervical alignment affects the motion of the upper and subaxial cervical spine using kinematic magnetic resonance imaging. SUMMARY OF BACKGROUND DATA: The sagittal malalignment of the cervical spine from degeneration in the subaxial cervical spine reflects a disruption in the kinematic properties of the cervical spine and affects the motion of adjacent segments...
January 8, 2018: Clinical Spine Surgery
Karine Evangelho, Maria Mogilevskaya, Monica Losada-Barragan, Jeinny Karina Vargas-Sanchez
PURPOSE: Glaucoma is the leading cause of blindness in humans, affecting 2% of the population. This disorder can be classified into various types including primary, secondary, glaucoma with angle closure and with open angle. The prevalence of distinct types of glaucoma differs for each particular region of the world. One of the most common types of this disease is primary open-angle glaucoma (POAG), which is a complex inherited disorder characterized by progressive retinal ganglion cell death, optic nerve head excavation and visual field loss...
December 30, 2017: International Ophthalmology
Łukasz Kubaszewski, Anetta Zioła-Frankowska, Zuzanna Gasik, Marcin Frankowski, Mikołaj Dąbrowski, Bartłomiej Molisak, Jacek Kaczmarczyk, Robert Gasik
BACKGROUND: The work is designed to uncover the pattern of mutual relation among trace elements and epidemiological data in the degenerated intervertebral disk tissue in humans. Hitherto the reason of the degenerative process is not fully understood. Trace elements are the basic components of the biological compound related both its metabolism as well as environmental exposure. The relation pattern among elements occurs gives new perspective in solving the cause of the disease. MATERIAL AND METHODS: We have analysed trace elements content in the 30 intervertebral disc from 22 patients with degenerative disc disease...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
Evgenii Belykh, Kaan Yagmurlu, Nikolay L Martirosyan, Ting Lei, Mohammadhassan Izadyyazdanabadi, Kashif M Malik, Vadim A Byvaltsev, Peter Nakaji, Mark C Preul
Background: Technological innovations based on light amplification created by stimulated emission of radiation (LASER) have been used extensively in the field of neurosurgery. Methods: We reviewed the medical literature to identify current laser-based technological applications for surgical, diagnostic, and therapeutic uses in neurosurgery. Results: Surgical applications of laser technology reported in the literature include percutaneous laser ablation of brain tissue, the use of surgical lasers in open and endoscopic cranial surgeries, laser-assisted microanastomosis, and photodynamic therapy for brain tumors...
2017: Surgical Neurology International
Li Li, Tong Shen, Yi-Kai Li
OBJECTIVE: This study aimed to investigate stress distribution and disk displacement in healthy and degenerated intervertebral disks during simulated lumbar rotation manipulation (LRM) in the sitting and side-lying positions. METHODS: Three-dimensional (3D) finite element models of healthy, mildly degenerated and moderately degenerated L4/5 spinal units were reconstructed. Lumbar rotation manipulation in the sitting and side-lying positions were simulated, and alterations in stress distribution and disk displacement in the lumbar disks were observed...
October 2017: Journal of Manipulative and Physiological Therapeutics
Bolong Zheng, Dingjun Hao, Hua Guo, Baorong He
BACKGROUND: ACDF has been considered as the gold standard in the treatment of single level cervical disk protrusion. However, it may cause adjacent level degeneration due to regional biomechanical changes. TDR has been applied with satisfactory results for over a decade, but there is no consensus if TDR is safer and more efficient than ACDF. The current study was carried out to compare the efficiency and safety of TDR and ACDF in the treatment of patients with single level cervical disk protrusion...
November 28, 2017: BMC Surgery
Stefan Schwan, Christopher Ludtka, Ingo Wiesner, Andre Baerthel, Andrea Friedmann, Felix Göhre
PURPOSE: This work describes a minimally invasive damage model for ovine lumbar discs via partial nucleotomy using a posterolateral approach. METHODS: Two cadavers were dissected to analyze the percutaneous corridor. Subsequently, 28 ovine had their annulus fibrosus punctured via awl penetration under fluoroscopic control and nucleus pulposus tissue removed via rongeur. Efficacy was assessed by animal morbidity, ease of access to T12-S1 disc spaces, and production of a mechanical injury as verified by discography, radiography, and histology...
January 2018: European Spine Journal
Nick D Jeffery, Paul M Freeman
Fenestration offers the advantages of prophylaxis without the need for specialized instrumentation and imaging. Currently there is a lack of equipoise regarding the efficacy of fenestration relative to decompression for treatment of acute canine intervertebral disk herniation; most veterinary spinal surgeons do not consider the 2 procedures equivalently efficacious. Therapeutic fenestration should perhaps be given greater consideration, especially if advanced imaging shows only mild to moderate spinal cord compression or there are restrictions on the duration of surgery, when it might be better to spend the time on fenestration rather than decompression...
January 2018: Veterinary Clinics of North America. Small Animal Practice
Li-Shan Huang, Ping-Ping Huang, Xiu-Bing Tong, Zhong-Li Li, Yan-Ping Fang, Jun Liao
OBJECTIVE: To observe the effect of chiropractics on intervertebral disk extracell matrix metalloproteinase (MMP)-1, MMP-3, MMP-13, cellular collagen type Ⅱ (COL-Ⅱ), tissue inhibitor 1 of metalloproteinase (TIMP-1) and extracellular matrix (ECM) in the rats with cervical spondylosis, so as to explore its mechanism underlying improvement of cervical spondylosis. METHODS: A total of 40 SD rats were randomized into a sham group, a model group, a chiropractics group and a mobic group, 8 rats in each one...
August 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
M Demir, M Kemal Tumer, M Çiçek, M Uysal, A Yoldas, A Doganer
BACKGROUND: The effects of aging on the histopathological changes of Temporomandibular joint (TMJ) and the existence and age related alterations of immunochemical expressions of type I collagen and matrix metalloproteinase-2 (MMP-2) proteins was aimed to be displayed. MATERIALS AND METHODS: In this study, 14 Balb/C type white mice (50-80g) were included. Groups were organized as Group I two month old young mice group (n=7) and Group II 18 month old mice group (n=7)...
October 24, 2017: Folia Morphologica (Warsz)
Kazuki Sakakura, Go Ikeda, Yasunobu Nakai, Noriyuki Watanabe, Masanari Shiigai, Kazuya Uemura, Tetsuya Yamamoto, Akira Matsumura
Although Terson's syndrome is a well-known cause of vision loss due to intracerebral aneurysm rupture, optic nerve neuropathy can also occur because of other causes. Here, we report such a case, i.e., a ruptured anterior communicating artery aneurysm accompanied by vision loss and visual field disturbances due to a cause other than Terson's syndrome. A 47-year-old man presented with right superior altitudinal hemianopia. Computed tomography (CT) showed subarachnoid hemorrhage (SAH), and three-dimensional CT angiography revealed an anterior communicating artery aneurysm...
October 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"