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Disk Degeneration

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https://www.readbyqxmd.com/read/27918900/differential-gene-expression-in-the-condylar-cartilage-of-growing-rabbits-with-temporomandibular-joint-anterior-disk-displacement-a-transcriptomic-study
#1
Shuhua Wang, Liquan Deng, Ye Li, Huiling Wu, Zhiyuan Gu
Internal derangement (ID) in the temporomandibular joint (TMJ) comprises a group of clinical problems with relatively high prevalence. However, the temporal changes in gene expression of condylar cartilage during continuous ID remain unclear. The aim of the current study is to investigate by microarray analysis, the differentially-expressed gene pattern in condylar cartilage of rabbits with ID from one to eight weeks of ID progression. Histological results (hematoxylin and eosin staining) indicated that abnormal collagen fiber arrangements, fragmentation of fibrils, and inflammatory cell-infiltration were detected from one to four weeks in joint disc specimens, while newly formed vessels, mucoid degeneration, meniscal tears, and the presence of osteoclasts and osteoblasts were observed at later time points...
November 6, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27906742/is-preexisting-cervical-disk-degeneration-a-prognostic-factor-in-whiplash-associated-disorders
#2
Nam-Su Chung, Chang-Hoon Jeon, Yu-Sang Lee, Jang-Ho Park, Han-Dong Lee
STUDY DESIGN: This is a retrospective control study. OBJECTIVE: We aimed to determine whether preexisting cervical disk degeneration is a prognostic factor in Whiplash-associated disorder (WAD). SUMMARY OF BACKGROUND DATA: WAD is a common injury of traffic accident and has a broad range of prognoses. Although numerous studies have investigated prognostic factors in WAD, few have evaluated the effect of preexisting disk degeneration. MATERIALS AND METHODS: This study involved 45 consecutive patients with grade I or II WAD having advanced disk degeneration (at least 1 disk of Miyazaki grade≥III on magnetic resonance imaging) and a control cohort of 52 patients with no or mild disk degeneration (all disks having Miyazaki grades≤II)...
November 30, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27879508/effect-of-an-annular-closure-device-barricaid-on-same-level-recurrent-disk-herniation-and-disk-height-loss-after-primary-lumbar-discectomy-two-year-results-of-a-multicenter-prospective-cohort-study
#3
Scott L Parker, Gordan Grahovac, Duje Vukas, Milorad Vilendecic, Darko Ledic, Matthew J McGirt, Eugene J Carragee
STUDY DESIGN: A prospective cohort study. OBJECTIVE: To evaluate whether an annular closure device could be implanted safely to reduce same-level recurrent disk herniation, or attenuate disk height loss and improve the outcome after lumbar discectomy. SUMMARY OF BACKGROUND DATA: Same-level recurrent disk herniation, disk height loss, and progressive degeneration are common complications and sequelae after lumbar discectomy. Techniques to reduce these consequences may improve outcomes...
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27853661/cell-therapy-with-human-dermal-fibroblasts-enhances-intervertebral-disk-repair-and-decreases-inflammation-in-the-rabbit-model
#4
Ana Chee, Peng Shi, Thomas Cha, Ting-Hsien Kao, Shu-Hua Yang, Jun Zhu, Ding Chen, Yejia Zhang, Howard S An
Study Design Pilot study using the rabbit model. Objective Low back pain is often associated with disk degeneration. Cell therapy for degenerating disks may promote tissue regeneration and repair. Human dermal fibroblasts, obtained from the patient's skin tissue or donated tissue, may be a promising cell therapy option for degenerating disks. The objective of these studies is to determine the effects of intradiscal transplantation of neonatal human dermal fibroblasts (nHDFs) on intervertebral disk (IVD) degeneration by measuring disk height, magnetic resonance imaging (MRI) signal intensity, gene expression, and collagen immunostaining...
December 2016: Global Spine Journal
https://www.readbyqxmd.com/read/27826214/clinical-outcome-following-diam-implantation-for-symptomatic-lumbar-internal-disk-disruption-a-3-year-retrospective-analysis
#5
Kang Lu, Po-Chou Liliang, Hao-Kuang Wang, Jui-Sheng Chen, Te-Yuan Chen, Ruyi Huang, Han-Jung Chen
BACKGROUND/OBJECTIVE: Internal disk disruption (IDD), an early event of lumbar disk degeneration, is the most common cause of low back pain. Since increased intradiskal pressure (IDP) is associated with symptoms and progression of disk degeneration, unloading a painful disk with an interspinous process device (IPD) is a rational treatment option. The goal of this study was to evaluate the effectiveness of dynamic stabilization with an IPD in the treatment of symptomatic IDD of the lumbar spine...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27807886/the-expression-of-cytokine-and-its-significance-for-the-intervertebral-disks-of-kazakhs
#6
Miao Xiaogang, Hou Quanshan, Zhang Liping, Habaxi Kaken
BACKGROUND: Proinflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 are expressed in herniated intervertebral disks of Kazakhs, but their significance is not yet understood. METHODS: Specimens of herniated lumbar disk were collected from 30 patients with single disk herniation during lumbar discectomy. As a control, 10 specimens were collected postmortem from the cadavers of individuals who did not die from spinal disease. The clinical symptoms in all cases were evaluated preoperation by the JOA index...
November 3, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27783214/selenium-reduces-early-signs-of-tumor-necrosis-factor-alpha-induced-meniscal-tissue-degradation
#7
Klaus Häfelein, Andrea Preuße-Prange, Peter Behrendt, Bodo Kurz
Meniscal integrity is a prerequisite for sustained knee joint health and prevention of meniscal degeneration is a main research goal. Cartilage-protective effects of selenium have been described, but little is known about the impact on the meniscus. We therefore investigated the influence of sodium selenite on meniscal explants under tumor necrosis factor-alpha (TNFα)-stimulated proinflammatory conditions. Meniscal explant disks (3 mm diameter × 1 mm thickness) were isolated from 2-year-old cattle and incubated with TNFα (10 ng/ml) and sodium selenite (low dose, LoD 6...
October 25, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27761804/the-presence-of-the-neuronal-nitric-oxide-synthase-isoform-in-the-intervertebral-disk
#8
Vitor Castania, Ana Carolina Issy, João Walter Silveira, Frederico Rogério Ferreira, Simoneide S Titze-de-Almeida, Fernando F B Resende, Nádia Rubia Ferreira, Ricardo Titze-de-Almeida, Helton L A Defino, Elaine Del Bel
Intervertebral disk degeneration is a progressive and debilitating disease with multifactorial causes. Nitric oxide (NO) might contribute to the cell death pathway. We evaluated the presence of the constitutive form of the neuronal NOS (nNOS) in both health and degenerated intervertebral disk through qPCR and immunohistochemistry. We also analyzed the potential role of nNOS modulation in the tail needle puncture model of intervertebral disk degeneration. Male Wistar rats were submitted to percutaneous disk puncture with a 21-gauge needle of coccygeal vertebras...
October 19, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27755207/imaging-evaluation-and-relative-significance-in-cases-of-cervical-disk-allografting-radiographic-character-after-total-disk-transplantation
#9
Yu Ding, Di-Ke Ruan, Qing He, Li Sheng Hou, Jian Ning Lin, Hong Peng Cui
STUDY DESIGN: The clinical and radiologic data of total disk allografting (TDA) cases were collected and analyzed to explore the correlation between neurological function improvements and imaging changes. OBJECTIVE: The aim of the study was to assess the medium-term and long-term outcome and radiographic character after TDA, and, furthermore, to explore the significance of the changes of imaging signs after the transplantation. SUMMARY OF BACKGROUND DATA: Spinal fusion may result in the adjacent segment degeneration...
November 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27755201/radiographic-adjacent-segment-degeneration-at-5-years-after-l4-5-posterior-lumbar-interbody-fusion-with-pedicle-screw-instrumentation-evaluation-by-computed-tomography-and-annual-screening-with-magnetic-resonance-imaging
#10
Shiro Imagama, Noriaki Kawakami, Yuji Matsubara, Taichi Tsuji, Tetsuya Ohara, Yoshito Katayama, Naoki Ishiguro, Tokumi Kanemura
STUDY DESIGN: Retrospective clinical study. OBJECTIVE: To investigate adjacent segment degeneration (ASD) at 5 years after L4/5 posterior lumbar interbody fusion with pedicle screw instrumentation and L4/5 decompression surgery using plain radiographs, computed tomography (CT), and magnetic resonance imaging (MRI), with the evaluation of annual changes on MRI. SUMMARY OF BACKGROUND DATA: Methods of evaluation have been inconsistent among studies of ASD...
November 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27742516/massive-lumbar-disc-herniation-following-therapeutic-water-boiling-of-the-lower-extremities-a-case-report-and-literature-review
#11
A Spallone, M Çelniku
A 49 years-old man came to our attention with severe flaccid paraparesis occurring 10 days before, almost immediately after he had immerged his legs in boiling water for treating his severe left lombo-crural pain. This was known to be due to a right L3-L4 herniated disk diagnosed by MRI. At the examination he showed severe motor paresis and absent reflexes of his lower limbs, whilst crural pain was very mild and sensation and urinary function were unaffected. The results of his neurological examination led us to suspect an acute motor axon degeneration related to the heating shock...
October 11, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27684084/spondylolysis-and-end-plate-arthrosis-at-l5-s1-a-cadaveric-study
#12
Peter T McCunniff, Hojun Yoo, Charles Yu, Navkirat S Bajwa, Jason O Toy, Uri M Ahn, Nicholas Ahn
This study examined the effect of bilateral and unilateral L5 pars defects on the degree of disk degeneration at the L5-S1 level in cadaveric specimens. An observational study was performed of 690 cadaveric specimens selected at random. These specimens represent individuals who died between 1893 and 1938. The study included 558 male and 132 female cadavers. Of the 120 specimens with L5 spondylolysis, 95 cases were bilateral and 25 were unilateral. The remaining 544 specimens were used as the control cohort...
September 29, 2016: Orthopedics
https://www.readbyqxmd.com/read/27661661/intervertebral-disc-repair-by-allogeneic-mesenchymal-bone-marrow-cells-a-randomized-controlled-trial
#13
David C Noriega, Francisco Ardura, Ruben Hernández-Ramajo, Miguel Angel Martín-Ferrero, Israel Sánchez-Lite, Borja Toribio, Mercedes Alberca, Veronica García, José Maria Moraleda, Ana Sánchez, Javier García-Sancho
BACKGROUND: Degenerative disc disease often causes severe low-back pain, a public health problem with huge economic and life quality impact. Chronic cases often require surgery, which may lead to biomechanical problems and accelerated degeneration of the adjacent segments. Autologous mesenchymal stromal cells (MSC) treatments have shown feasibility, safety and strong indications of clinical efficacy. We present here a randomized, controlled trial using allogeneic MSC, which are logistically more convenient than autologous cells...
September 21, 2016: Transplantation
https://www.readbyqxmd.com/read/27630802/a-novel-minimally-invasive-approach-to-repair-degenerative-disk-disease-in-an-ovine-model-using-injectable-polymethyl-methacrylate-and-bovine-collagen-pmma-bc
#14
Reid Hoshide, Erica Feldman, Anisha Narayan, William Taylor
BACKGROUND: The natural, inflammatory repair processes of an injured intervertebral degenerative disc can propagate further injury and destruction. While there are many different treatment modalities of the pain related to degenerative disc disease, none are actually reparative in nature. Treatment strategies to repair a degenerative disc without inducing a destructive inflammatory milieu have been elusive.  PURPOSE: The purpose of this experiment is to discover the feasibility of reconstructing an injured intervertebral disc using an injected, inert polymer as the foundation for endogenous collagen growth...
2016: Curēus
https://www.readbyqxmd.com/read/27590020/matrix-homeostasis-within-the-immature-annulus-fibrosus-depends-on-the-frequency-of-dynamic-compression-a-study-based-on-the-self-developed-mechanically-active-bioreactor
#15
Pei Li, Yibo Gan, Yuan Xu, Lei Song, Haoming Wang, Chengmin Zhang, Liyuan Wang, Chen Zhao, Lei Luo, Qiang Zhou
Evidence suggests that mechanical load is related to structural destruction of disk annulus fibrosus (AF) either in adult disk degeneration or in child disk acute injury. Both biochemical and biomechanical properties are different between immature and mature disks. However, the effects of mechanical compression on immature AF are not fully clear. This study was to investigate the effects of a relatively wide range of dynamic compressive frequency on matrix homeostasis within the immature AF. Immature disks from pig (3-4 months) were randomly assigned into the control group (non-compression) and compression groups (0...
September 2, 2016: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/27567635/a-prospective-randomized-multicenter-phase-i-ii-clinical-trial-to-evaluate-safety-and-efficacy-of-novocart-disk-plus-autologous-disk-chondrocyte-transplantation-in-the-treatment-of-nucleotomized-and-degenerative-lumbar-disks-to-avoid-secondary-disease-safety
#16
Anja Tschugg, Michael Diepers, Steinert Simone, Felix Michnacs, Sebastian Quirbach, Martin Strowitzki, Hans Jörg Meisel, Claudius Thomé
NOVOCART(®) Disk plus, an autologous cell compound for autologous disk chondrocyte transplantation, was developed to reduce the degenerative sequel after lumbar disk surgery or to prophylactically avoid degeneration in adjacent disks, if present. The NDisc trial is an ongoing multi-center, randomized study with a sequential phase I study within the combined phase I/II trial with close monitoring of tolerability and safety. Twenty-four adult patients were randomized and treated with the investigational medicinal product NDisc plus or the carrier material only...
August 27, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27536737/rate-of-lumbar-paravertebral-muscle-fat-infiltration-versus-spinal-degeneration-in-asymptomatic-populations-an-age-aggregated-cross-sectional-simulation-study
#17
Rebecca J Crawford, Thomas Volken, Stephanie Valentin, Markus Melloh, James M Elliott
BACKGROUND: The spinal column including its vertebrae and disks has been well examined and extensively reported in relation to age-aggregated degeneration. In contrast, paravertebral muscles are poorly represented in describing normative degeneration. Increasing evidence points to the importance of paravertebral muscle quality in low back health, and their potential as a modifiable factor in low back pain (LBP). Studies examining normative decline of paravertebral muscles are needed to advance the field's etiological understanding...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27505961/-biomechanical-analysis-on-the-correlation-between-iliac-rotation-displacement-and-l-4-5-disc-degeneration
#18
Ning-ning Shi, Guo-quan Shen, Shui-yong He, Ru-bao Guo
OBJECTIVE: To study the biomechanical relationship between iliac rotation displacement and L(4,5) disc degeneration, and to provide clinical evidences for the prevention and treatment of L(4,5) disc degeneration and herniation. METHODS: From March 2012 to February 2014,68 patients with lumbar disc herniation combined with sacroiliac joint disorders were selected. Among them, 42 patients with L(4,5) disc herniation combined with sacroiliac joint disorders included 22 males and 20 females, ranging in age from 19 to 63 years old, with an average of (51...
May 2016: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/27484337/periodic-mechanical-stress-induces-the-extracellular-matrix-expression-and-migration-of-rat-nucleus-pulposus-cells-by-upregulating-the-expression-of-intergrin-%C3%AE-1-and-phosphorylation-of-downstream-phospholipase-c%C3%AE-1
#19
Gongming Gao, Jin He, Luming Nong, Hua Xie, Yongjing Huang, Nanwei Xu, Dong Zhou
Intervertebral disk degeneration (IDD) is a major cause of low back pain and an important socioeconomic burden. Degradation of the extracellular matrix (ECM) of nucleus pulposus (NP) cells in the interverterbal disk is important for IDD. Stress of a suitable frequency and amplitude promotes the synthesis of the ECM of NP cells, however, the associated mechanisms remain to be fully elucidated The present study aimed to investigate the effect of integrin α1 on the migration and ECM synthesis of NP cells under soft periodic mechanical stress...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27467379/photoreceptor-inner-segment-morphology-in-best-vitelliform-macular-dystrophy
#20
Drew Scoles, Yusufu N Sulai, Robert F Cooper, Brian P Higgins, Ryan D Johnson, Joseph Carroll, Alfredo Dubra, Kimberly E Stepien
PURPOSE: To characterize outer retina structure in best vitelliform macular dystrophy (BVMD) and to determine the effect of macular lesions on overlying and adjacent photoreceptors. METHODS: Five individuals with BVMD were followed prospectively with spectral domain optical coherence tomography and confocal and nonconfocal split-detector adaptive optics scanning light ophthalmoscopy (AOSLO). The AOSLO cone photoreceptor mosaic images were obtained within and around retinal lesions...
October 3, 2016: Retina
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