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https://www.readbyqxmd.com/read/29235901/a-novel-mixed-polymeric-micelle-for-co-delivery-of-paclitaxel-and-retinoic-acid-and-overcoming-multidrug-resistance-synthesis-characterization-cytotoxicity-and-pharmacokinetic-evaluation
#1
Jaber Emami, Mahboubeh Rezazadeh, Mahboubeh Mashayekhi, Mahboubeh Rostami, Ali Jahanian-Najafabadi
In the current study, retinoic acid (RA) was conjugated to Pluronic F127 (PF127) through an esterification process. Mixed micelles were formed with tocopheryl polyethylene glycol 1000 (TPGS) for co-delivery of paclitaxel (PTX) and RA to the cancer cells. Mixed micelles of RA-PF127 and TPGS in different weight ratios (10:0, 7:3, 5:5, 3:7, 0:10 w/w) were prepared and physicochemical properties including, particle size, zeta potential, critical micelle concentration (CMC), drug loading content, entrapment efficiency, drug release, cellular uptake and in vitro cytotoxicity, were investigated in details...
December 13, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29234659/accessory-muscle-of-the-flexor-digitorum-superficialis-and-its-clinical-implications
#2
Edie Benedito Caetano, João José Sabongi Neto, Lucas Augusto Ayres Ribas, Edson Vinícius Milanello
Anatomical variations of the flexor digitorum superficialis (FDS) muscle and tendon unit are frequently reported by anatomists and clinicians. Anatomical muscle variations of the FDS and its tendons may include variations of muscle belly, presence of accessory or duplicate tendons, abnormal tendon connections, and absence of muscle or tendon components. Such variations may or may not have clinical implications. This report presents a case not described previously: a unilateral accessory muscle of the flexor digitorum superficialis which was connected by a thick tendon to the flexor digitorum superficialis muscle; it was directed proximally to the insertion of the medial epicondyle of the humerus, next to the superficialis head of the pronator teres muscle...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29234567/nerve-entrapment-in-the-hip-region-current-concepts-review
#3
RobRoy Martin, Hal David Martin, Benjamin R Kivlan
The purpose of this clinical commentary is to review the anatomy, etiology, evaluation, and treatment techniques for nerve entrapments of the hip region. Nerve entrapment can occur around musculotendinous, osseous, and ligamentous structures because of the potential for increased strain and compression on the peripheral nerve at those sites. The sequela of localized trauma may also result in nerve entrapment if normal nerve gliding is prevented. Nerve entrapment can be difficult to diagnose because patient complaints may be similar to and coexist with other musculoskeletal conditions in the hip and pelvic region...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29234313/food-grade-pimenta-leaf-essential-oil-reduces-the-attachment-of-salmonella-enterica-heidelberg-2011-ground-turkey-outbreak-isolate-on-to-turkey-skin
#4
Divek V T Nair, Anup Kollanoor Johny
Salmonella attached to the poultry skin is a major source of carcass contamination during processing. Once attached to the poultry skin, it is difficult to detach and inactivate Salmonella by commonly used antimicrobial agents since the pathogen is entrapped deeply in the feather follicles and the crevices on the skin. Essential oils could be natural, safe, and effective alternatives to synthetic antimicrobial agents during commercial and organic processing setup. The present study evaluated the efficacy of pimenta (Pimenta officinalis Lindl...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29231740/conserved-activity-of-reassociated-homotetrameric-protein-subunits-released-from-mesoporous-silica-nanoparticles
#5
Gauri V Deodhar, Marisa L Adams, Sutapa Joardar, Madhura Joglekar, Malcolm Davidson, Madelyn Mettler, Sydney A Toler, Fiona Davies, Brian G Trewyn
Mesoporous silica nanoparticles (MSN) with enlarged pores were prepared, characterized, and reversibly dissociated subunits of Concanavalin A were entrapped in the mesopores as shown by multiple biochemical and material characterizations. When loaded in the MSN, we demonstrated protein stability from proteases and, upon release, the subunits reassociated into active proteins shown through mannose binding. We have demonstrated a versatile and facile method to load multisubunit proteins into MSN with potential applications in enhancing the delivery of large therapeutic proteins...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29231058/efaverinz-and-nano-gold-loaded-mannosylated-niosomes-a-host-cell-targeted-topical-hiv-1-prophylaxis-via-thermogel-system
#6
Tanushree Malik, Gaurav Chauhan, Goutam Rath, Rohan N Kesarkar, Abhay S Chowdhary, Amit K Goyal
Sexual dissemination of Human Immunodeficiency Virus-1 (HIV-1) is the prime mode of its spread. Topical microbicidal approach has gained much attention, but no real success is observed till date, either due to toxicity or resistance of active moieties and the lack of efficient drug delivery approaches. In this research protocol, a unique combination approach of a standard drug moiety, that is, Efaverinz (EFV) and a nanometal, that is, gold nanoparticles (GNPs) was tried. Both these candidates were delivered through a mannosylated niosomal system, to exploit protein (lectins present on HIV host cells) - carbohydrate (oligosaccharides such as mannan present on HIV gp-120 receptor) interaction...
December 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29230740/-peroneal-nerve-entrapment-syndrome
#7
REVIEW
Alexander Schuh, René Handschu, Thomas Eibl, Michael Janka, Wolfgang Hönle
No abstract text is available yet for this article.
December 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29229951/a-new-high-pressure-form-of-mg2sio4-highlighting-diffusionless-phase-transitions-of-olivine
#8
Naotaka Tomioka, Takuo Okuchi
High-pressure polymorphism of olivine (α-phase of Mg2SiO4) is of particular interest for geophysicists aiming to understand the structure and dynamics of the Earth's interior because of olivine's prominent abundance in the upper mantle. Therefore, natural and synthetic olivine polymorphs have been actively studied in the past half century. Here, we report a new high-pressure polymorph, the ε*-phase, which was discovered in a heavily shocked meteorite. It occurs as nanoscale lamellae and has a topotaxial relationship with the host ringwoodite (γ-phase of Mg2SiO4)...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29227373/incidence-of-meniscal-entrapment-and-associated-knee-injuries-in-tibial-spine-avulsions
#9
Jason T Rhodes, Peter C Cannamela, Aristides I Cruz, Meredith Mayo, Alexandra C Styhl, Connor G Richmond, Theodore J Ganley, Kevin G Shea
BACKGROUND: Tibial spine avulsions (TSA) have historically been treated as isolated injuries. Data on associated injuries are limited with existing literature reporting wide ranging incidences. The purpose of this multicenter study was to (1) describe the incidence of meniscal entrapment and associated knee injuries in TSA and to (2) compare surgical and magnetic resonance image (MRI) findings for these injuries. Our hypothesis is that tibial spine injuries are not usually isolated injuries, and other meniscal, ligament, and cartilage injuries may be present...
December 8, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29226503/development-characterization-and-evaluation-of-sunscreen-cream-containing-solid-lipid-nanoparticles-of-silymarin
#10
Gladyston Netto MPharm, Jobin Jose
BACKGROUND: Most of the sunscreen formulations mainly contain chemicals or synthetic molecules. Nowadays, researchers are mainly focussing on herbal formulations due to toxicity of the synthetic molecules. Silymarin is a natural flavonoids having excellent antioxidant properties. Solid lipid nanoparticles are novel drug carriers which improve the drug stability and tolerance effect and also enhance the permeation effect. AIMS: This study aimed at the preparation of solid lipid nanoparticles containing silymarin that will be incorporated into a sunscreen cream and determine its sun protection factor...
December 10, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29225897/-bottom-hung-window-trauma-in-cats-neurological-evaluation-and-outcome-in-71-cats-with-bilateral-hindlimb-injury
#11
Gabriele M Gradner, Lina Dogman-Rauberger, Gilles Dupré
Objectives: Influence of neurological status on the mortality rate of paraparetic/paralysed cats presenting after entrapment in a bottom-hung window was evaluated. It was hypothesised that (1) loss of deep pain sensation at admission would not be a negative prognostic factor for regaining motor function and that (2) mortality rate would be influenced by the severity of neurological grade upon admission. Methods: Clinical and pathological data of affected cats that presented at our institution between 2001 and 2012 for this specific trauma were collected retrospectively: breed, age, sex, last contact with owner (<3 hours and >3 hours), whether the cat was suffering from monoparesis or paraparesis/paraplegia, duration of hospitalisation, rectal temperature, surface temperature of the skin of the hindlimbs, femoral pulse and tone of the pelvic musculature...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/29225861/accidental-knotting-and-subsequent-removal-of-a-catheter-from-the-epidural-space-in-an-adult-cow-a-case-report
#12
Graeme M Doodnaught, Caroline Constant, André Desrochers, Daniel S J Pang
This is the first reported case in the veterinary literature of a knot in an epidural catheter. The report reviews this very rare complication and describes options for investigation and retrieval of catheters entrapped in the epidural space of any species.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29225609/efficiency-of-trichome-based-plant-defense-in-phaseolus-vulgaris-depends-on-insect-behavior-plant-ontogeny-and-structure
#13
Zhenlong Xing, Yongqiang Liu, Wanzhi Cai, Xinzheng Huang, Shengyong Wu, Zhongren Lei
Plant trichomes often function as physical barriers in preventing arthropod feeding and oviposition. Even though insects are frequently reported being entrapped and killed by trichome traps, the actual trapping behavior has not yet been described in detail. Capture experiments showed that capture efficiency during the plant's vegetative stage was considerably higher than in the fruiting and cotyledon stages. The ventral surface of the leaf was more effective in trapping flies than other parts of the plant. Capture-events monitoring showed that the mouthparts, legs, and ovipositor of Liriomyza trifolii adults are the body parts involved in entrapment by surface trichomes on Phaseolus vulgaris plants, and subsequently, deter their ability to feed, walk, and oviposit...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29225176/synthesis-of-biaryls-using-palladium-nanoparticles-immobilized-on-metformine-functionalized-polystyrene-resin-as-a-reusable-and-efficient-nanocatalyst
#14
Hojat Veisi, Seyed Ahmad Mirshokraie, Hossein Ahmadian
This study includes the procedure performed for the Pd@PS-Met preparation as a novel polymeric nanocatalyst, in which to entrapped palladium nanoparticles (Pd NPs) without agglomeration, metformine groups are applied (as linkers). The obtained catalyst could be evaluated using transmission electron microscopy (TEM), wavelength-dispersive X-ray spectroscopy (WDX), scanning electron microscopy (SEM), X-ray powder diffraction (XRD), inductively coupled plasma (ICP), fourier transform infrared (FTIR), and Energy-dispersive X-ray spectroscopy (EDS)...
December 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29224930/transport-of-dissolved-organic-matter-in-boom-clay-size-effects
#15
D Durce, M Aertsens, D Jacques, N Maes, M Van Gompel
A coupled experimental-modelling approach was developed to evaluate the effects of molecular weight (MW) of dissolved organic matter (DOM) on its transport through intact Boom Clay (BC) samples. Natural DOM was sampled in-situ in the BC layer. Transport was investigated with percolation experiments on 1.5cm BC samples by measuring the outflow MW distribution (MWD) by size exclusion chromatography (SEC). A one-dimensional reactive transport model was developed to account for retardation, diffusion and entrapment (attachment and/or straining) of DOM...
December 5, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29223119/bio-fabrication-of-silver-nanoparticles-as-an-effective-wound-healing-agent-in-the-wound-care-after-anorectal-surgery
#16
Yating Wang, Yinghong Qiao, Pei Wang, Qiang Li, Chaofeng Xia, Man Ju
Nowadays biological mediated syntheses of metal nanoparticles were utilized for various life caring applications. Our research group utilized Delonix elata leaf aqueous extract for the synthesis of silver nanoparticles. Further the synthesized silver nanoparticles were subjected for various characterization techniques which resulted in spherically agglomerated with biological components entrapped in it and also with average particle size of 36nm were studied and reported. Later the synthesized silver nanoparticles were subjected for wound healing property by size of measured lessions and body weight which results in better wound healing property were studied and discussed...
October 27, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29223048/extraction-protocol-and-liquid-chromatography-tandem-mass-spectrometry-method-for-determining-micelle-entrapped-paclitaxel-at-the-cellular-and-subcellular-levels-application-to-a-cellular-uptake-and-distribution-study
#17
Nan Zheng, Bin Lian, Wenwen Du, Guobing Xu, Jiafu Ji
Paclitaxel-loaded polymeric micelles (PTX-PM) are commonly used as tumor-targeted nanocarriers and display outstanding antitumor features in clinic, but its accumulation and distribution in vitro are lack of investigation. It is probably due to the complex micellar system and its low concentration at the cellular or subcellular levels. In this study, we developed an improved extraction method, which was a combination of mechanical disruption and liquid-liquid extraction (LLE), to extract the total PTX from micelles in the cell lysate and subcellular compartments...
December 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29222698/efficacy-evaluation-of-iclaprim-in-a-neutropenic-rat-lung-infection-model-with-methicillin-resistant-staphylococcus-aureus-entrapped-in-alginate-microspheres
#18
David B Huang, Ian Morrissey, Timothy Murphy, Stephen Hawser, Mark H Wilcox
The objective of this study was to demonstrate the efficacy of iclaprim in a neutropenic rat lung infection model with methicillin-resistant Staphylococcus aureus (MRSA) entrapped in alginate beads. An inoculum of 5.25 × 105 colony-forming units (CFU)/mL of S. aureus strain AH1252 was administered intratracheally to rats with prepared alginate bacteria suspensions. Beginning 2 h post-infection, rats received: (1) iclaprim 80 mg/kg (n = 16); (2) iclaprim 60 mg/kg (n = 16), or (3) vancomycin 50 mg/kg (n = 24), for 3 days via subcutaneous (SC) injection every 12 h...
December 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29222673/ureteric-entrapment-in-sacroiliac-joint-causing-hydroureter-and-ipsilateral-kidney-hypertrophy
#19
Yurie Otsuru, Chuichi Kondo, Shohei Hara, Hideo Takahashi, Kenjiro Matsuno
A unilateral megaureter was found in an elderly female cadaver during routine dissection. The left proximal ureter, which was thick and convolute, descended and entered into the pelvic cavity, where the distal ureter was attached to the posterior pelvic wall at the inlet level. Removal of connective tissue surrounding the attached region revealed ureteric entrapment in the sacroiliac joint. The ipsilateral kidney, from which the megaureter originated, showed no pelvicalyceal dilatation. In contrast, the left kidney was enlarged, weighing 24% more than the right kidney...
December 8, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/29219628/penetration-enhancer-containing-spanlastics-pecss-for-transdermal-delivery-of-haloperidol-in-vitro-characterization-ex-vivo-permeation-and-in-vivo-biodistribution-studies
#20
Abdurrahman M Fahmy, Doaa Ahmed El-Setouhy, Ahmed B Ibrahim, Basant A Habib, Saadia A Tayel, Noha A Bayoumi
Haloperidol (Hal) is one of the widely used antipsychotic drugs. When orally administered, it suffers from low bioavailability due to hepatic first pass metabolism. This study aimed at developing Hal-loaded penetration enhancer-containing spanlastics (PECSs) to increase transdermal permeation of Hal with sustained release. PECSs were successfully prepared using ethanol injection method showing reasonable values of percentage entrapment efficiency, particle size, polydispersity index and zeta potential. The statistical analysis of the ex vivo permeation parameters led to the choice of F1L - made of Span® 60 and Tween® 80 at the weight ratio of 4:1 along with 1% w/v Labrasol® - as the selected formula (SF)...
November 2018: Drug Delivery
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