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https://www.readbyqxmd.com/read/28324689/calcium-phosphate-quercetin-nanocomposite-cpqn-a-multi-functional-nanoparticle-having-ph-indicating-highly-fluorescent-and-anti-oxidant-properties
#1
Mousumi Patra, Riya Mukherjee, Milon Banik, Debanjan Dutta, Naznin Ara Begum, Tarakdas Basu
Calcium phosphate quercetin nanocomposite (CPQN) i.e., quercetin entrapped in calcium phosphate nanoparticle was synthesized by a precipitation method at 80°C, taking ammonium hydrogen phosphate, calcium nitrate and quercetin as precursors and sodium citrate as stabilizer. The nanocomposite suspension had different color at different pH values, a property that could render the nanoparticle a pH indicator. Besides color, the particles also had different size, shape, stability and quercetin content with change of pH...
March 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28324320/tailoring-the-properties-of-mpeg-plla-nanoparticles-for-better-encapsulation-and-tuned-release-of-the-hydrophilic-anticancer-drug
#2
Sachin S Surwase, Neha M Munot, Bhaskar B Idage, Susheela B Idage
Gemcitabine is used as a first-line drug for treating many solid tumours. However, it suffers from a major drawback of strong side effects and short plasma half-life because of degradation by enzyme when administered intravenously. Polyesters and copolyesters are the most widely used and preferred class of biodegradable polymer. In the present work, efforts have been made to prepare poly(ethylene glycol) monomethoxy ether-poly(L-lactide) (mPEG-PLLA), a biodegradable amphiphilic copolymer with a view to improve the entrapment and tuned release of hydrophilic drug gemcitabine...
March 21, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28323883/ubiquitously-expressed-human-beta-defensin-1-hbd1-forms-bacteria-entrapping-nets-in-a-redox-dependent-mode-of-action
#3
Judith Raschig, Daniela Mailänder-Sanchez, Anne Berscheid, Jürgen Berger, Adam A Strömstedt, Lioba F Courth, Nisar P Malek, Heike Brötz-Oesterhelt, Jan Wehkamp
Ever since the discovery of endogenous host defense antimicrobial peptides it has been discussed how these evolutionary conserved molecules avoid to induce resistance and to remain effective. An Human ß-defensin 1 (hBD1) is an ubiquitously expressed endogenous antimicrobial peptide that exhibits qualitatively distinct activities between its oxidized and reduced forms. Here, we explore these antimicrobial mechanisms. Surprisingly, using electron microscopy we detected a so far unknown net-like structure surrounding bacteria, which were treated with the reduced but not the oxidized form of hBD1...
March 21, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28323700/electrophysiological-study-for-nerve-root-entrapment-in-patients-with-isthmic-spondylolisthesis
#4
Masahiro Morita, Akira Miyauchi, Shinya Okuda, Takenori Oda, Motoki Iwasaki
STUDY DESIGN: A case series study. OBJECTIVE: To investigate the electrophysiological location of nerve root entrapment in patients with isthmic spondylolisthesis. SUMMARY OF BACKGROUND DATA: Although the lesion of the nerve root in patients with isthmic spondylolisthesis has been thought to be located at the pars interarticularis due to proliferation of fibrous cartilage, there is no electrophysiological study in relation to this accomplished fact...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28319816/dna-polyplexes-with-dendritic-glycopolymer-entrapped-gold-nanoparticles
#5
Jens Rumschöttel, Sabine Kosmella, Claudia Prietzel, Dietmar Appelhans, Joachim Koetz
Polyplexes, composed of Salmon DNA and very small gold nanoparticles embedded into a dendritic glycopolymer architecture of sugar-modified poly(ethyleneimine) (PEI-Mal) with a molar mass of about 25,000g/mol, were characterized by dynamic light scattering (DLS), zeta potential measurements, micro differential scanning calorimetry (μ-DSC) and transmission electron microscopy (TEM). The PEI-Mal-entrapped gold nanoparticles of about 2nm in diameter influence the polyplex formation of the hyperbranched PEI containing bulky maltose, and in consequence the DNA is more compactized in the inner part of spherical polyplex particles of about 150nm in diameter...
March 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28319694/sexual-trauma-is-more-strongly-associated-with-tonic-immobility-than-other-types-of-trauma-a-population-based-study
#6
Juliana Kalaf, Evandro Silva Freire Coutinho, Liliane Maria Pereira Vilete, Mariana Pires Luz, William Berger, Mauro Mendlowicz, Eliane Volchan, Sergio Baxter Andreoli, Maria Inês Quintana, Jair de Jesus Mari, Ivan Figueira
BACKGROUND: Tonic immobility is an involuntary motor and vocal inhibition reaction, considered the last-ditch response of the defensive cascade model. It is elicited in context of inescapable threat and perception of entrapment. Our aim was to investigate the association between different traumatic events and peritraumatic tonic immobility (PTI) in a representative sample of the general population. METHODS: This is a cross-sectional study of general population from Rio de Janeiro and São Paulo with 3231 victims of traumatic events aged 15-75 years who completed the Tonic Immobility Scale (TIS)...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28319384/eugenol-nanoemulsion-stabilized-with-zein-and-sodium-caseinate-by-self-assembly
#7
Lei Wang, Yue Zhang
Eugenol-loaded nanoemulsion by zein and sodium caseinate (NaCas) was prepared without using specific equipment or organic solvents. The deprotonated eugenol in hot alkaline was added into NaCas/zein mixtures with different mass ratios at pH 11.5, and then neutralized to pH 7.0. The nanoemulsions showed well-defined diameter (around 109-139 nm) and negative surface potential (-28.5~ -35.8 mv). The entrapment efficiency (EE) of 1% v/v eugenol reached 84.24% by 2% m/v NaCas/zein at a mass ratio of 1:1. This formulation also showed the narrowest size distribution, extraordinary stability during ambient storage (22 oC) up to 30 days, and retained good re-dispersiblity after spray- or freeze- drying...
March 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28317731/encapsulation-of-sesamol-in-phosphatidyl-choline-micelles-enhanced-bioavailability-and-anti-inflammatory-activity
#8
P S Yashaswini, Nawneet K Kurrey, Sridevi A Singh
Sesamol, the phenolic degradation product of sesamolin, although recognised for its anti-inflammatory effects, has low bioavailability. In this manuscript, we attempted to improve its bioavailability by encapsulation in mixed phosphatidylcholine micelles. Sesamol could be solubilised and entrapped in phosphatidylcholine mixed micelles (PCS) with 96.8% efficiency (particle size 3.0±0.06nm). Fluorescence spectra of PCS revealed lower relative fluorescence intensity (RFI 112) compared to 'free' sesamol (FS) (RFI 271)...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28315446/targeted-delivery-of-morin-a-dietary-bioflavanol-encapsulated-mannosylated-liposomes-to-the-macrophages-of-adjuvant-induced-arthritis-rats-inhibits-inflammatory-immune-response-and-osteoclastogenesis
#9
Farhath Sultana, Manoj Kumar Neog, MahaboobKhan Rasool
The purpose of the study was to develop a liposomal drug delivery system for morin, a dietary polyphenol, in order to target the synovial macrophages and investigate the remission of disease severity in the adjuvant-induced arthritic (AIA) rats. To do so, mannose decorated liposomal morin (ML-Morin) was prepared using the thin film hydration method and the physicochemical properties were characterized. The particle size and zeta potential of liposomal morin (L-Morin) was found to be 127.9nm ± 2.6 and -24.5mV ± 0...
March 14, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28315435/pharmacokinetic-study-of-solid-lipid-nanoparticles-of-altretamine-complexed-epichlorohydrin-%C3%AE-cyclodextrin-for-enhanced-solubility-and-oral-bioavailability
#10
Bina Gidwani, Amber Vyas
Altretamine is a synthetic drug approved for treatment of ovarian cancer. The only drawback with its formulation is poor aqueous solubility and low oral bioavailability. In the present work an attempt has been made to prepare inclusion complex of altretamine with epichlorohydrin beta cyclodextrin. The complexes were prepared by kneading, co-evaporation and freeze-drying method and were confirmed by FTIR, XRD, DSC, drug content and dissolution study. Kneaded complex posses maximum solubilizing efficiency of 82...
March 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28306747/hypothermic-stunning-of-green-sea-turtles-in-a-western-gulf-of-mexico-foraging-habitat
#11
Donna J Shaver, Philippe E Tissot, Mary M Streich, Jennifer Shelby Walker, Cynthia Rubio, Anthony F Amos, Jeffrey A George, Michelle R Pasawicz
Texas waters provide one of the most important developmental and foraging habitats for juvenile green turtles (Chelonia mydas) in the western Gulf of Mexico, but hypothermic stunning is a significant threat and was the largest cause of green turtle strandings in Texas from 1980 through 2015; of the 8,107 green turtles found stranded, 4,529 (55.9%) were victims of hypothermic stunning. Additionally, during this time, 203 hypothermic stunned green turtles were found incidentally captured due to power plant water intake entrapment...
2017: PloS One
https://www.readbyqxmd.com/read/28306692/carpal-tunnel-syndrome-grading-using-high-resolution-ultrasonography
#12
Hala R El Habashy, Reem A El Hadidy, Sandra M Ahmed, Basma B El Sayed, Aya S Ahmed
PURPOSE: Carpal tunnel syndrome (CTS) is a common entrapment neuropathy of the wrist. The diagnosis of CTS has been a concern for physicians for a long time. The aim of this study is to evaluate the use of the median nerve (MN) cross-sectional area (CSA) in the wrist compared with the CSA in the forearm to grade the severity of CTS in Egyptian patients. METHODS: The CSAs of the MN in the wrist and forearm were measured in 72 wrists that were diagnosed with CTS via nerve conduction studies and 80 healthy wrists...
March 16, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28304160/nucleosome-histone-tail-conformation-and-dynamics-impacts-of-lysine-acetylation-and-a-nearby-minor-groove-benzo-a-pyrene-derived-lesion
#13
Iwen Fu, Yuqin Cai, Nicholas E Geacintov, Yingkai Zhang, Suse Broyde
Histone tails in nucleosomes play critical roles in regulation of many biological processes, including chromatin compaction, transcription, and DNA repair. Moreover, post-translational modifications, notably lysine acetylation, are crucial to these functions. While the tails have been intensively studied, how the structures and dynamics of tails are impacted by the presence of a nearby bulky DNA lesion is a frontier research area, and how these properties are impacted by tail lysine acetylation remains unexplored...
March 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28303912/new-technologies-for-the-assessment-of-neuropathies
#14
REVIEW
Roberto Gasparotti, Luca Padua, Chiara Briani, Giuseppe Lauria
Technical advances are rapidly changing the clinical and instrumental approach to peripheral nerve diseases. Magnetic resonance neurography, diffusion tensor imaging and nerve ultrasonography are increasingly entering the diagnostic workup of peripheral neuropathies as tools that complement neurophysiology and enable investigation of proximal structures, such as plexuses and roots. Progress in the design of magnetic resonance scanners and sequences, and the development of high-frequency ultrasound probes mean that high-resolution peripheral nerve imaging is possible, enabling detailed examination of nerve size, morphology and internal fascicular structure that can integrate nerve conduction studies into clinical practice...
March 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28302668/sulphated-glycosaminoglycans-support-an-assortment-of-planarian-rhabdite-structures
#15
Matthew J Hayes
Planaria are soft-bodied, bilateral flatworms of the phylum Playhelminthes. They are covered in cilia and use ciliary-gliding to traverse the substratum while hunting. Their body surface is covered in a layer of viscous slime primarily derived from specialised secretory granules known as rhabdites. The slime must somehow stay associated with the surface of the animal in aqueous environments whilst also lubricating the interface of the animal and the surfaces over which the animal moves. The slime prevents damage to the animal's soft body and also contributes to adhesion to the substratum...
March 16, 2017: Biology Open
https://www.readbyqxmd.com/read/28302049/increased-enzymatic-hydrolysis-of-sugarcane-bagasse-by-a-novel-glucose-and-xylose-stimulated-%C3%AE-glucosidase-from-anoxybacillus-flavithermus-subsp-yunnanensis-e13-t
#16
Yang Liu, Rui Li, Jing Wang, Xiaohan Zhang, Rong Jia, Yi Gao, Hui Peng
BACKGROUND: β-Glucosidase is claimed as a key enzyme in cellulose hydrolysis. The cellulosic fibers are usually entrapped with hemicelluloses containing xylose. So there is ongoing interest in searching for glucose- and xylose-stimulated β-glucosidases to increase the efficiency of hydrolysis of cellulosic biomass. RESULTS: A thermostable β-glucosidase gene (Bglp) was cloned from Anoxybacillus flavithermus subsp. yunnanensis E13(T) and characterized. Optimal enzyme activity was observed at 60 °C and pH 7...
March 16, 2017: BMC Biochemistry
https://www.readbyqxmd.com/read/28301717/glucose-triggered-insulin-release-from-fe3-cross-linked-alginate-hydrogel-experimental-study-and-theoretical-modeling
#17
Evgeny Katz, Sabrina Scheja, Sergii Domanskyi, Maria Gamella, Kelly L Wormwood, Costel C Darie, Arshak Poghossian, Michael J Schöning, Artem Melman, Vladimir Privman
We study the mechanisms involved in the release, triggered by the application of glucose, of insulin entrapped in Fe3+-cross-linked alginate hydrogel particles further stabilized with a polyelectrolyte. Platelet-shaped alginate particles are synthesized containing enzyme glucose oxidase conjugated with silica nanoparticles, which are also entrapped in the hydrogel. Glucose diffuses in from solution, and production of hydrogen peroxide is catalyzed by the enzyme within the hydrogel. We argue that, specifically for the Fe3+-cross-linked systems, the produced hydrogen peroxide is further converted to free radicals via a Fenton-type reaction catalyzed by the iron cations...
March 16, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28301164/effect-of-meso-vs-macro-size-of-hierarchical-porous-silica-on-the-adsorption-and-activity-of-immobilized-%C3%AE-galactosidase
#18
Ileana-Alexandra Pavel, Sofia F Prazeres, Gemma Montalvo, Carmen Garcia-Ruiz, Vincent Nicolas, Alain Celzard, Francois Dehez, Laetitia Canabady-Rochelle, Nadia Canilho, Andreea Pasc
β-galactosidase (β-Gal) is one of the most important enzymes used in milk processing for improving their nutritional quality and digestibility. Herein, β-Gal has been entrapped into a meso-macroporous material (average pore size 9 and 200 nm, respectively) prepared by a sol-gel method from a silica precursor and a dispersion of solid lipid nanoparticles in a micelle phase. The physisorption of the enzyme depends on the concentration of the feed solution and on the pore size of the support. The enzyme is preferentially adsorbed either in mesopores or in macropores, depending on its initial concentration...
March 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28301065/dinuclear-crown-ether-palladium-complex-a-highly-effective-strategy-for-encapsulating-potassium-cations-in-small-crown-ether-rings
#19
Jose M Vila, Fatima Lucio-Martinez, Brais Bermudez, Juan Ortigueira, Harry Adams, M Teresa Pereira, Alberto Fernandez
The potential of 15-crown-5 ethers to link rather large cations as potassium is limited to the quasi parallel arrangement of two oxygen donor moieties upon appropriate orientation of the corresponding ether ring containing molecules. Substrates bearing the two crown ethers capable of achieving such coordination are hitherto unknown. The synthesis and isolation of a tailored-made dinuclear palladacycle bearing 15-crown-5 ether rings on the metallated phenyls offers such a possibility providing the adequate environment for the formation of the sandwiched [K(metalacycle-15-crown-5)2] moiety...
March 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28300578/cellular-interactions-of-the-phosphorylated-form-of-akt-in-prostate-cancer
#20
Kai H Hammerich, Anna Frolov, Rile Li, Michael Ittmann, Gustavo E Ayala
Phospho-Akt (P-Akt1) promotes proliferation and increased survival in vitro and plays an important role in prostate cancer (PCa) progression as well as the prediction of the probability of recurrence. In this study, the goal was to demonstrate the involvement and impact of P-Akt1 on cellular interactions, biomechanisms and pathways in PCa. Tissue microarrays from 640 PCa patients were immunostained with various antibodies. Ki67 was used to measure proliferation index and Tunnel for apoptotic index. Increased expression of P-Akt1 was associated with an increased proliferation, but inversely correlated with apoptotic index...
March 11, 2017: Human Pathology
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