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https://www.readbyqxmd.com/read/28231139/evaluation-of-the-bitterness-masking-effect-of-powdered-roasted-soybeans
#1
Yoshimasa Makita, Tomoko Ishida, Noriko Kobayashi, Mai Fujio, Kyoko Fujimoto, Rina Moritomo, Jun-Ichi Fujita, Shin-Ichi Fujiwara
The masking of bitterness is considered important because many pharmaceutical compounds have a bitter taste. The bitterness-masking effect of powdered roasted soybeans (PRS) was investigated using a bitter taste sensor. PRS was revealed to significantly suppress the bitterness of quinine hydrochloride and denatonium benzoate. Furthermore, the bitterness-masking mechanism of PRS extracts was evaluated using dynamic light scattering. These results showed that the extracted suspension consisted of particles that were several hundreds of nanometers in size...
June 18, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231125/fundamental-study-on-the-impact-of-gluten-free-starches-on-the-quality-of-gluten-free-model-breads
#2
Stefan W Horstmann, Markus C E Belz, Mareile Heitmann, Emanuele Zannini, Elke K Arendt
Starch is widely used as an ingredient and significantly contributes to texture, appearance, and overall acceptability of cereal based foods, playing an important role due to its ability to form a matrix, entrapping air bubbles. A detailed characterisation of five gluten-free starches (corn, wheat, rice, tapioca, potato) was performed in this study. In addition, the influence of these starches, with different compositional and morphological properties, was evaluated on a simple gluten-free model bread system...
April 21, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230764/cinnamic-acid-and-its-derivatives-mechanisms-for-prevention-and-management-of-diabetes-and-its-complications
#3
REVIEW
Sirichai Adisakwattana
With recent insight into the development of dietary supplements and functional foods, search of effective phytochemical compounds and their mechanisms involved in prevention and management of diabetes and its complications are now being assessed. Cinnamic acid and its derivatives occur naturally in high levels of plant-based foods. Among various biological activities, cinnamic acid and its derivatives are associated with a beneficial influence on diabetes and its complications. The aim of the review is to summarize the potential mechanisms of these compounds for prevention and management of diabetes and its complications...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28229944/development-and-in-vivo-evaluation-of-an-innovative-hydrochlorothiazide-in-cyclodextrins-in-solid-lipid-nanoparticles-formulation-with-sustained-release-and-enhanced-oral-bioavailability-for-the-hypertension-treatment-in-pediatrics
#4
Marzia Cirri, Natascia Mennini, Francesca Maestrelli, Paola Mura, Carla Ghelardini, Lorenzo di Cesare Mannelli
An innovative pediatric oral formulation of hydrochlorothiazide (HCT) (2mg/mL), endowed with improved bioavailability and sustained release properties and suitable for the hypertension treatment in pediatric patients, was developed by combining the drug-cyclodextrin complexation and the incorporation of the complex into Solid Lipid Nanoparticles (SLN). Precirol(®)ATO5-based SLN, with two different surfactants (Pluronic(®)F68 and Tween(®)80) loaded with the drug as such or as binary system with hydroxypropyl-beta-cyclodextrin (HPβCd) and sulfobutyl-ether-beta-cyclodextrin (SBEβCd) both as physical mixture (P...
February 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28226286/peripheral-nerve-ultrasonography-in-patients-with-transthyretin-amyloidosis
#5
Simon Podnar, Stayko Sarafov, Ivailo Tournev, Gregor Omejec, Janez Zidar
OBJECTIVE: To systematically study peripheral nerve morphology in patients with transthyretin (TTR) amyloidosis and TTR gene mutation carriers using high-resolution ultrasonography (US). METHODS: In this prospective cross-sectional study we took a structured history, performed neurological examination, and measured peripheral nerve cross-sectional areas (CSAs) bilaterally at 28 standard locations using US. Demographic and US findings were compared to controls. RESULTS: Peripheral nerve CSAs were significantly larger in 33 patients with familial amyloid polyneuropathy (FAP) compared to 50 controls, most dramatically at the common entrapment sites (median nerve at the wrist, ulnar nerve at the elbow), and in the proximal nerve segments (median nerve in the upper arm, sciatic nerve in the thigh)...
January 29, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28224390/plga-nanoparticles-as-subconjunctival-injection-for-management-of-glaucoma
#6
Hamed A Salama, Mahmoud Ghorab, Azza A Mahmoud, Mayssa Abdel Hady
Nanoparticles fabricated from the biodegradable and biocompatible polymer, polylactic-co-glycolic acid (PLGA), could be a promising system for targeting ocular drug delivery. The objective of this work was to investigate the possibility of encapsulating brinzolamide in PLGA nanoparticles in order to be applied as a subconjunctival injection that could represent a starting point for developing new therapeutic strategies against increase in ocular pressure. The brinzolamide-loaded PLGA nanoparticles were fabricated using emulsion-diffusion-evaporation method with varying concentrations of Tween 80 or poloxamer 188 (Plx) in aqueous and organic phases...
February 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28224244/preparation-of-magnetic-melamine-formaldehyde-resin-and-its-application-to-extract-nonsteroidal-anti-inflammatory-drugs
#7
Shu-Wen Xue, Jing Li, Li Xu
Magnetic melamine-formaldehyde resin was prepared via water-in-oil emulsification approach by entrapping Fe3O4 magnetic nanoparticles as the core. The preparation of the magnetic resin was optimized by investigating the amount of polyethylene glycol 20000 and Fe3O4 nanoparticles, the concentration of the catalyst (hydrochloric acid), as well as the mechanical stirring rate. The prepared material was characteristic of excellent anion-exchange capacity, good water wettability, and proper magnetism. Its application was demonstrated by magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs coupled to high performance liquid chromatography-UV analysis...
February 21, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28222399/improved-yeast-delivery-of-fluconazole-with-a-nanostructured-lipid-carrier-system
#8
Hamid Reza Kelidari, Maryam Moazeni, Roghayeh Babaei, Majid Saeedi, Jafar Akbari, Parisa Islami Parkoohi, Mojtaba Nabili, Atefeh Abdollahi Gohar, Katayoun Morteza-Semnani, Ali Nokhodchi
Despite the growing trends in the number of patients at risk for invasive fungal infections, management with current antifungal agents results in complications due to changes in the epidemiology and drug susceptibility of invasive fungal infections. In the present research fluconazole-loaded nanostructured lipid carriers were prepared using probe ultrasonication techniques and investigated the efficacy of the optimal formulation on a large number of Candida species. The morphology of the obtained nanostructured lipid carriers was characterized by transmission-electron microscopy...
February 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28220956/releasing-the-cohesin-ring-a-rigid-scaffold-model-for-opening-the-dna-exit-gate-by-pds5-and-wapl
#9
Zhuqing Ouyang, Hongtao Yu
The ring-shaped ATPase machine, cohesin, regulates sister chromatid cohesion, transcription, and DNA repair by topologically entrapping DNA. Here, we propose a rigid scaffold model to explain how the cohesin regulators Pds5 and Wapl release cohesin from chromosomes. Recent studies have established the Smc3-Scc1 interface as the DNA exit gate of cohesin, revealed a requirement for ATP hydrolysis in ring opening, suggested regulation of the cohesin ATPase activity by DNA and Smc3 acetylation, and provided insights into how Pds5 and Wapl open this exit gate...
February 21, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28220607/neurological-and-spinal-manifestations-of-the-ehlers-danlos-syndromes
#10
Fraser C Henderson, Claudiu Austin, Edward Benzel, Paolo Bolognese, Richard Ellenbogen, Clair A Francomano, Candace Ireton, Petra Klinge, Myles Koby, Donlin Long, Sunil Patel, Eric L Singman, Nicol C Voermans
The Ehlers-Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin extensibility, and tissue fragility. This communication briefly reports upon the neurological manifestations that arise including the weakness of the ligaments of the craniocervical junction and spine, early disc degeneration, and the weakness of the epineurium and perineurium surrounding peripheral nerves. Entrapment, deformation, and biophysical deformative stresses exerted upon the nervous system may alter gene expression, neuronal function and phenotypic expression...
February 21, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28220386/clogging-development-and-hydraulic-performance-of-the-horizontal-subsurface-flow-stormwater-constructed-wetlands-a-laboratory-study
#11
Ping Tang, Bohai Yu, Yongchao Zhou, Yiping Zhang, Jin Li
The horizontal subsurface constructed wetland (HSSF CW) is a highly effective technique for stormwater treatment. However, progressive clogging in HSSF CW is a widespread operational problem. The aim of this study was to understand the clogging development of HSSF CWs during stormwater treatment and to assess the influence of microorganisms and vegetation on the clogging. Moreover, the hydraulic performance of HSSF CWs in the process of clogging was evaluated in a tracer experiment. The results show that the HSSF CW can be divided into two sections, section I (circa 0-35 cm) and section II (circa 35-110 cm)...
February 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28218822/single-molecular-junction-study-on-h2o-c60-h2o-is-electrostatically-isolated
#12
Satoshi Kaneko, Yoshifumi Hashikawa, Shintaro Fujii, Yasujiro Murata, Manabu Kiguchi
A water molecule exhibits characteristic properties on the basis of hydrogen-bondings. In the past decade, a single water molecule placed in the non-hydrogen-bonding environment has attracted growing attention. To reveal fundamental properties of a single water molecule, endohedral fullerene H2O@C60 becomes an ideal and suitable model. We examined the electronic properties of H2O@C60 by applying the single-molecule measurement. The conductance of a single molecular junction based on H2O@C60 was found to be comparable with that of empty C60...
February 20, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28217661/winged-scapula-caused-by-rhomboid-paralysis-a-case-report
#13
Maria Grazia Benedetti, Alessandro Zati, Silvia Bonfiglioli Stagni, Isabella Fusaro, Roberta Monesi, Roberto Rotini
Scapular winging secondary to dorsal scapular nerve (DSN) damage is an underestimated condition. It is often caused by entrapment of the nerve due to a hypertrophic middle scalene muscle, or by stretching of the DSN during traumatic movements. The condition has also been attributed to myofascial pain syndrome of the rhomboids with entrapment of the DSN. The non-specific symptomatology reported by patients is often incorrectly diagnosed, and this can result in a high level of disability of the upper limb. A clinical case of misdiagnosed dorsal scapula entrapment is presented...
October 2016: Joints
https://www.readbyqxmd.com/read/28216437/extracellular-eosinophilic-traps-in-association-with-staphylococcus-aureus-at-the-site-of-epithelial-barrier-defects-in-severe-airway-inflammation
#14
Elien Gevaert, Nan Zhang, Olga Krysko, Feng Lan, Gabriële Holtappels, Natalie De Ruyck, Hans Nauwynck, Shida Yousefi, Hans-Uwe Simon, Claus Bachert
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a Th2-biased eosinophilic inflammation. Eosinophils have been shown to generate so-called extracellular eosinophilic traps (EETs) under similar pathological conditions. OBJECTIVE: Our aim was to investigate a possible link between EET formation and the presence of Staphylococcus aureus, an organism frequently colonizing the upper airways, at the human mucosal site of the disease. METHODS: Tissue slides were investigated for the presence of EETs and S...
February 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28216300/boronic-acid-tethered-amphiphilic-hyaluronic-acid-derivative-based-nanoassemblies-for-tumor-targeting-and-penetration
#15
Jae Young Jeong, Eun-Hye Hong, Song Yi Lee, Jae-Young Lee, Jae-Hyoung Song, Seung-Hak Ko, Jae-Seong Shim, Sunghwa Choe, Dae-Duk Kim, Hyun-Jeong Ko, Hyun-Jong Cho
(3-Aminomethylphenyl)boronic acid (AMPB)-installed hyaluronic acid-ceramide (HACE)-based nanoparticles (NPs), including manassantin B (MB), were fabricated for tumor-targeted delivery. The amine group of AMPB was conjugated to the carboxylic acid group of hyaluronic acid (HA) via amide bond formation, and synthesis was confirmed by spectroscopic methods. HACE-AMPB/MB NPs with a 239-nm mean diameter, narrow size distribution, negative zeta potential, and > 90% drug encapsulation efficiency were fabricated...
February 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28216135/fate-of-phenanthrene-and-mineralization-of-its-non-extractable-residues-in-an-oxic-soil
#16
Yongfeng Wang, Jun Xu, Jun Shan, Yini Ma, Rong Ji
The fate of organic pollutants in the environment, especially the formation and stability of non-extractable (i.e., bound) residues (NERs) determines their environmental risk. Using (14)C-tracers, we studied the fate of the carcinogen phenanthrene in active or sterilized oxic loamy soil in the absence and presence of the geophagous earthworm Metaphire guillelmi and characterized the NERs derived from phenanthrene. After incubation of (14)C-phenanthrene in active soil for 28 days, 40 ± 3.1% of the initial amount was mineralized and 70...
February 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28215563/chitosan-immobilized-novel-peroxidase-from-azadirachta-indica-characterization-and-application
#17
Veda P Pandey, Jyoti Rani, Nivedita Jaiswal, Swati Singh, Manika Awasthi, Ajit K Shasany, Sameeksha Tiwari, Upendra N Dwivedi
In the present paper, a peroxidase was purified from the leaves of a medicinal tree, namely Azadirachta indica, to 45.2 folds with overall recovery of 61%. Based on the subunit size, the purified peroxidase was suggested to be a monomeric structure of size 50kDa and exhibited good thermostability as it was fully stable at 65°C for 1hr and also retained about 73% activity at 70°C till 30min. The substrate affinity was found to be in order of guaiacol > pyrogallol > o-dianisidine. The purified peroxidase was found to be insensitive towards high concentrations of Na(+), Ca(2+), Mg(2+) and Mn(2+)...
February 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28215553/organization-of-rescue-behaviour-sequences-in-ants-cataglyphis-cursor-reflects-goal-directedness-plasticity-and-memory
#18
Thierry Duhoo, Jean-Luc Durand, Karen L Hollis, Elise Nowbahari
The experimental study of rescue behaviour in ants, behaviour in which individuals help entrapped nestmates in distress, has revealed that rescuers respond to victims with very precisely targeted behaviour. In Cataglyphis cursor, several different components of rescue behaviour have been observed, demonstrating the complexity of this behaviour, including sand digging and sand transport to excavate the victim, followed by pulling on the victim's limbs as well as the object holding the victim in place, behaviour that serves to free the victim...
February 12, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28215511/popliteal-artery-entrapment-syndrome-in-children-experience-with-four-cases-of-acute-ischaemia-and-review-of-the-literature
#19
REVIEW
N Settembre, Z Bouziane, M A Bartoli, V Nabokov, M Venermo, P Feugier, S Malikov
OBJECTIVE: Popliteal artery entrapment syndrome (PAES) is an uncommon anatomical anomaly, frequently described in adults. The most common symptom is claudication. Acute limb ischaemia (ALI) in children is rare, but it may evolve and lead to limb loss or lifelong complications. Clinical and surgical experience of PAES in children is reported. Data from the literature are analysed in order to assess the severity of this disease and to identify the factors characterising the diagnosis and the outcome of treatment in paediatric patients...
February 16, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28213218/dynamic-flow-through-approach-to-evaluate-readily-bioaccessible-antioxidants-in-solid-food-samples
#20
Miguel A Maia, Tânia R P Soares, Ana I P Mota, María Rosende, Luís M Magalhães, Manuel Miró, Marcela A Segundo
Release of bioactive compounds from food matrices is regarded as the first step towards their human bioavailability. The objective of this work was the implementation of an affordable and robust flow-through device for expedient dynamic leaching experiments aiming at the assessment of readily bioaccessible antioxidant compounds in solid food commodities. A simple configuration is proposed using commercially available devices containing regenerated cellulose filters placed in polypropylene holders to entrap the solid sample, featuring a disposable, single use extraction chamber...
May 1, 2017: Talanta
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