keyword
https://read.qxmd.com/read/38488878/the-prediction-of-estimated-cerebral-perfusion-pressure-with-trans-systolic-time-in-preterm-and-term-infants
#21
JOURNAL ARTICLE
Masashi Zuiki, Mikito Ohta, Naoe Fujita, Daisuke Uda, Madoka Uesugi, Akio Yamano, Eisuke Ichise, Hidechika Morimoto, Kanae Hashiguchi, Daisuke Kinoshita, Tatsuji Hasegawa, Tomoko Iehara
It is important to monitor cerebral perfusion in infants because hypo- and hyperperfusion can contribute to neurological injury. This study aimed to clarify the relationship between trans-systolic time (TST) and critical closing pressure (CrCP) or estimated cerebral perfusion pressure (CPPe) in neonates. Moreover, we aimed to determine the TST values in preterm and term infants with stable cerebral perfusion to clarify normative reference data. This multicentre prospective study included infants with arterial lines admitted to the neonatal intensive care units between December 2021 and August 2023...
March 15, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38488628/brachial-plexus-birth-injuries-a-multi-speciality-approach-commentary-and-opinions
#22
EDITORIAL
Dan A Zlotolow
The management of brachial plexus birth injuries (BPBI) remains controversial and ever evolving. In this article, studies are examined to provide further insight into the ongoing controversies and debates surrounding BPBI. The articles are diverse and examine the topics of aetiology, demographics, reliability versus accuracy of measurements and surgical management. The management of BPBI may differ depending on resources. Outcome measures may also vary depending on geography. Future research should focus on developing consensus-validated measures and reproducible surgical techniques...
March 15, 2024: Journal of Hand Surgery, European Volume
https://read.qxmd.com/read/38488462/heimler-syndrome-with-a-complaint-of-blurred-vision-caused-by-compound-heterozygous-variants-in-pex1
#23
JOURNAL ARTICLE
Yanchen Zhang, Zhixing Li, Bing Lin, Xiaoling Liu, Zuhua Sun
INTRODUCTION: Heimler syndrome (HS) is a rare disorder that includes sensorineural hearing loss (SNHL), nail abnormalities, and enamel hypoplasia. Patients with this syndrome can also exhibit ocular manifestations. At present, only a few cases of HS have been reported, existing knowledge of this syndrome is limited, and many cases have been misdiagnosed or even missed. This is the first report of Heimler syndrome with blurred vision as the first complaint, which was diagnosed by genetic analysis in the ophthalmology department...
March 15, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38484753/global-age-sex-specific-mortality-life-expectancy-and-population-estimates-in-204-countries-and-territories-and-811-subnational-locations-1950-2021-and-the-impact-of-the-covid-19-pandemic-a-comprehensive-demographic-analysis-for-the-global-burden-of-disease
#24
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020-21 COVID-19 pandemic period...
March 8, 2024: Lancet
https://read.qxmd.com/read/38483391/teen-pregnancy-and-risk-of-premature-mortality
#25
JOURNAL ARTICLE
Joel G Ray, Longdi Fu, Peter C Austin, Alison L Park, Hilary K Brown, Sonia M Grandi, Ashley Vandermorris, Alexa Boblitz, Eyal Cohen
IMPORTANCE: Unintentional injury, suicide, and homicide are leading causes of death among young females. Teen pregnancy may be a marker of adverse life experiences. OBJECTIVE: To evaluate the risk of premature mortality from 12 years of age onward in association with number of teen pregnancies and age at pregnancy. DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study was conducted among all females alive at 12 years of age from April 1, 1991, to March 31, 2021, in Ontario, Canada (the most populous province, which has universal health care and data collection)...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38481797/parp1-promotes-heart-regeneration-and-cardiomyocyte-proliferation
#26
JOURNAL ARTICLE
Jiangcheng Shu, Shu Yan, Chenhui Ju, Long Chen, Minglu Liang, Cheng Wang, Kai Huang
Myocardial infarction causes cardiomyocyte loss, and depleted cardiomyocyte proliferative capacity after birth impinges the heart repair process, eventually leading to heart failure. This study aims to investigate the role of Poly(ADP-Ribose) Polymerase 1 (PARP1) in the regulation of cardiomyocyte proliferation and heart regeneration. Our findings demonstrated that PARP1 knockout impaired cardiomyocyte proliferation, cardiac function, and scar formation, while PARP1 overexpression improved heart regeneration in apical resection-operated mice...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38479452/characterization-of-protein-lactylation-in-relation-to-cardiac-metabolic-reprogramming-in-neonatal-mouse-hearts
#27
JOURNAL ARTICLE
Tongyu Zhang, Yingxi Zhu, Xiaochen Wang, Danyang Chong, Haiquan Wang, Dandan Bu, Mengfei Zhao, Lei Fang, Chaojun Li
In mammals, the neonatal heart can regenerate upon injury within a short time after birth, while adults lose this ability. Metabolic reprogramming has been demonstrated to be critical for cardiomyocyte proliferation in the neonatal heart. Herein, we reveal that cardiac metabolic reprogramming could be regulated by altering global protein lactylation. Through performing 4D label-free proteomics and lysine lactylation (Kla) omics analyses in postnatal day 1, 5, and 7 mouse hearts, 2297 Kla sites from 980 proteins are identified, among which 1262 Kla sites from 409 proteins are quantified...
March 11, 2024: Journal of Genetics and Genomics
https://read.qxmd.com/read/38470173/ethnic-background-as-a-risk-factor-for-permanent-brachial-plexus-birth-injury-a-population-based-study
#28
JOURNAL ARTICLE
Petra Grahn, Mika Gissler, Yrjänä Nietosvaara, Marja Kaijomaa
INTRODUCTION: Brachial plexus birth injury is the most common birth injury causing permanent disability in Finland. This study aimed to assess risk factors of a permanent brachial plexus birth injury and calculate the incidence. MATERIAL AND METHODS: This is a retrospective population-based study including all deliveries between 2006 and 2022 in Southern Finland. The number of children born, obstetric data, and migrant status were gathered from the registries of the Finnish Institute for Health and Welfare, and Statistics Finland...
March 12, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38468947/risk-and-protective-factors-for-self-harm-thoughts-and-behaviours-in-transgender-and-gender-diverse-people-a-systematic-review
#29
REVIEW
K Bird, J Arcelus, L Matsagoura, B A O'Shea, E Townsend
BACKGROUND: Self-harm (any self-injury or -poisoning regardless of intent) is highly prevalent in transgender and gender diverse (TGD) populations. It is strongly associated with various adverse health and wellbeing outcomes, including suicide. Despite increased risk, TGD individuals' unique self-harm pathways are not well understood. Following PRISMA guidelines we conducted the first systematic review of risk and protective factors for self-harm in TGD people to identify targets for prevention and intervention...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38467191/endothelial-slc35a1-deficiency-causes-loss-of-lsec-identity-and-exacerbates-neonatal-lipid-deposition-in-the-liver-in-mice
#30
JOURNAL ARTICLE
Bin Zuo, Fei Yang, Lulu Huang, Jingjing Han, Tianyi Li, Zhenni Ma, Lijuan Cao, Yun Li, Xia Bai, Miao Jiang, Yang He, Lijun Xia
BACKGROUND & AIMS: The functional maturation of the liver largely occurs after birth. In the early stages of life, the liver of a newborn encounters enormous high-fat metabolic stress caused by the consumption of breast milk. It is unclear how the maturing liver adapts to high lipid metabolism. Liver sinusoidal endothelial cells (LSECs) play a fundamental role in establishing liver vasculature and are decorated with many glycoproteins on their surface. The Slc35a1 gene encodes a CMP-sialic acid transporter responsible for transporting CMP-sialic acids between the cytoplasm and the Golgi apparatus for protein sialylation...
March 9, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38467046/infantile-traumatic-pericallosal-aneurysm-illustrative-case
#31
JOURNAL ARTICLE
Zachary S Hubbard, Conor M Cunningham, Brian F Saway, Matthew J Triano, Aaron T Miller, Guilherme Porto, Libby Kosnik Infinger, Alejandro M Spiotta
BACKGROUND: Traumatic aneurysms are a rare sequela of nonaccidental head trauma in infants. The rate of nonaccidental trauma (NAT) in the pediatric population is increasing; therefore, traumatic aneurysms are an important consideration in the evaluation of pediatric patients with abusive head trauma. OBSERVATIONS: A 24-day-old infant with no significant past medical or birth history presented with twitching and poor oral intake for 1 day. The patient was found to have bilateral subdural hematomas, multifocal contusions, and traumatic subarachnoid hemorrhage...
March 11, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38462267/management-of-impacted-fetal-head-at-cesarean-delivery
#32
REVIEW
Katie R Cornthwaite, Rachna Bahl, Katherine Lattey, Tim Draycott
Globally, more than 1 in 5 women give birth by cesarean delivery, and at least 5% of these births are at full cervical dilatation. In these circumstances, and when labor has been prolonged in the first stage of labor, the fetal head can become low and wedged deep in the woman's pelvis, making it difficult to deliver the baby. This emergency is known as impacted fetal head. These are technically challenging births associated with serious risks to both the woman and the baby. The difficulty in disimpacting the fetal head increases maternal risks of hemorrhage and injury to adjacent organs and may have long-term consequences for future pregnancies...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462266/water-birth-a-systematic-review-and-meta-analysis-of-maternal-and-neonatal-outcomes
#33
JOURNAL ARTICLE
Jordan A McKinney, Gustavo Vilchez, Alicia Jowers, Amanda Atchoo, Lifeng Lin, Andrew M Kaunitz, Kendall E Lewis, Luis Sanchez-Ramos
OBJECTIVE: This systematic review and meta-analysis aimed to conduct a thorough and contemporary assessment of maternal and neonatal outcomes associated with water birth in comparison with land-based birth. DATA SOURCES: We conducted a comprehensive search of PubMed, EMBASE, CINAHL, and gray literature sources, from inception to February 28, 2023. STUDY ELIGIBILITY CRITERIA: We included randomized and nonrandomized studies that assessed maternal and neonatal outcomes in patients who delivered either conventionally or while submerged in water...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462264/the-odonassist-inflatable-device-for-assisted-vaginal-birth-the-assist-ii-study-united-kingdom
#34
RANDOMIZED CONTROLLED TRIAL
Emily J Hotton, Nichola Bale, Claire Rose, Paul White, Julia Wade, Nicolas Mottet, Abi J Loose, Mohamed Elhodaiby, Erik Lenguerrand, Tim J Draycott, Joanna F Crofts
BACKGROUND: Decreasing rates of assisted vaginal birth have been paralleled with increasing rates of cesarean deliveries over the last 40 years. The OdonAssist is a novel device for assisted vaginal birth. Iterative changes to clinical parameters, device design, and technique have been made to improve device efficacy and usability. OBJECTIVE: This study aimed to determine if the feasibility, safety, and efficacy of the OdonAssist device were sufficient to justify conducting a future randomized controlled trial...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462263/assisted-vaginal-birth-in-21st-century-current-practice-and-new-innovations
#35
REVIEW
Rachna Bahl, Emily Hotton, Joanna Crofts, Tim Draycott
Assisted vaginal birth rates are falling globally with rising cesarean delivery rates. Cesarean delivery is not without consequence, particularly when carried out in the second stage of labor. Cesarean delivery in the second stage is not entirely protective against pelvic floor morbidity and can lead to serious complications in a subsequent pregnancy. It should be acknowledged that the likelihood of morbidity for mother and baby associated with cesarean delivery increases with advancing labor and is greater than spontaneous vaginal birth, irrespective of the method of operative birth in the second stage of labor...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462251/parturition-at-term-induction-second-and-third-stages-of-labor-and-optimal-management-of-life-threatening-complications-hemorrhage-infection-and-uterine-rupture
#36
EDITORIAL
Roberto Romero, Virginia Sabo Romero, Karim D Kalache, Joanne Stone
Childbirth is a defining moment in anyone's life, and it occurs 140 million times per year. Largely a physiologic process, parturition does come with risks; one mother dies every two minutes. These deaths occur mostly among healthy women, and many are considered preventable. For each death, 20 to 30 mothers experience complications that compromise their short- and long-term health. The risk of birth extends to the newborn, and, in 2020, 2.4 million neonates died, 25% in the first day of life. Hence, intrapartum care is an important priority for society...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38459740/early-versus-late-caffeine-and-or-non-steroidal-anti-inflammatory-drugs-nsaids-for-prevention-of-intermittent-hypoxia-induced-neuroinflammation-in-the-neonatal-rat
#37
JOURNAL ARTICLE
Myra Batool, Charles L Cai, Jacob V Aranda, Ivan Hand, Kay D Beharry
Preterm infants often experience frequent intermittent hypoxia (IH) episodes which are associated with neuroinflammation. We tested the hypotheses that early caffeine and/or non-steroidal inflammatory drugs (NSAIDs) confer superior therapeutic benefits for protection against IH-induced neuroinflammation than late treatment. Newborn rats were exposed to IH or hyperoxia (50% O2 ) from birth (P0) to P14. For early treatment, the pups were administered: 1) daily caffeine (Caff) citrate (Cafcit, 20 mg/kg IP loading on P0, followed by 5 mg/kg from P1-P14); 2) ketorolac (Keto) topical ocular solution in both eyes from P0 to P14; 3) ibuprofen (Ibu, Neoprofen, 10 mg/kg loading dose on P0 followed by 5 mg/kg/day on P1 and P2); 4) Caff+Keto co-treatment; 5) Caff+Ibu co-treatment; or 6) equivalent volume saline (Sal)...
March 8, 2024: International Journal of Developmental Neuroscience
https://read.qxmd.com/read/38458802/incidence-contributing-factors-and-outcomes-of-birth-injury-among-newborns-in-africa-a-systematic-review-of-quantitative-evidence-protocol
#38
JOURNAL ARTICLE
Abera Mersha, Shitaye Shibiru
INTRODUCTION: Birth injury is a significant public health problem in Africa, with a high incidence and associated mortality and morbidity. Systematic reviews that indicate the incidence, contributing factors and outcomes of birth injury in Africa provide valuable evidence to policy-makers and programme planners for improving prevention and treatment strategies. Therefore, this review is aimed to evaluate the incidence, contributing factors and outcomes of birth injury among newborns in Africa...
March 8, 2024: BMJ Open
https://read.qxmd.com/read/38448376/correlation-between-preoperative-three-dimensional-transvaginal-ultrasound-and-postoperative-pregnancy-outcomes-after-hysteroscopic-adhesiolysis
#39
JOURNAL ARTICLE
Jing Zhou, Dabao Xu, Xingping Zhao, Yajun Li
OBJECTIVES: Uterine adhesion is mainly caused by endometrial injury, leading to poor postoperative pregnancy outcome. Therefore, preoperative evaluation on uterine cavity, especially endometrial condition, is very necessary. This study aims to explore the correlation between preoperative three-dimensional transvaginal ultrasound (3D-TVS) imaging characteristics and postoperative pregnancy outcomes after hysteroscopic adhesiolysis (HA). METHODS: A total of 401 patients, who underwent HA surgery from February 22, 2018 to October 31, 2018 at the Third Xiangya Hospital of Central South University or Changsha Jiangwan Hospital, were enrolled, and we collected data regarding the preoperative 3D-TVS imaging characteristics and followed up their postoperative pregnancy outcomes...
December 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/38447679/the-association-between-unintended-hysterotomy-extensions-with-cesarean-delivery-and-subsequent-preterm-birth
#40
JOURNAL ARTICLE
Giulia M Muraca, Tzuria Peled, Abirami Kirubarajan, Ari Weiss, Hen Y Sela, Sorina Grisaru-Granovsky, Misgav Rottenstreich
BACKGROUND: An increased risk of preterm birth has been observed among individuals with a previous second stage cesarean delivery compared with a previous vaginal delivery. One mechanism that may contribute to the increased risk of preterm birth following second stage cesarean delivery is the increased risk of cervical injury due to extension of the uterine incision (hysterotomy) into the cervix. Investigating the contribution of hysterotomy extension to the rate of preterm birth has not been well-studied and may shed light on the mechanisms underlying the observed relationship between mode of delivery and subsequent preterm birth...
March 4, 2024: American journal of obstetrics & gynecology MFM
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