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https://www.readbyqxmd.com/read/28810994/comparison-of-point-of-care-versus-laboratory-troponin-testing-in-an-emergency-department-setting
#1
Michael Juliano, Courtney Wason
BACKGROUND: There have been concerns regarding troponin results accuracy between point-of-care (POC) testing preformed in an emergency department (ED) setting and laboratory testing. The purpose of this study was to compare the results of cardiac troponin I testing as concerns POC testing and laboratory analysis as a way to show that these results are interchangeable. METHODS: A retrospective chart review was performed from October 2012 through September 2013 to identify all patients who presented to the ED that received both a POC and laboratory troponin associated with the same blood draw...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28807819/carrier-characteristics-influence-the-kinetics-of-passive-drug-loading-into-lipid-nanoemulsions
#2
Katrin Göke, Heike Bunjes
Passive loading as a novel screening approach is a material-saving tool for the efficient selection of a suitable colloidal lipid carrier system for poorly water soluble drug candidates. This method comprises incubation of preformed carrier systems with drug powder and subsequent determination of the resulting drug load of the carrier particles after removal of excess drug. For reliable routine use and to obtain meaningful loading results, information on the kinetics of the process is required. Passive loading proceeds via a dissolution-diffusion based mechanism, where drug surface area and drug water solubility are key parameters for fast passive loading...
August 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28807463/clinical-analysis-of-matrixmandible-preformed-reconstruction-plate-design
#3
Fabian Duttenhoefer, Florian Andreas Probst, Kirstin Vach, Carl-Peter Cornelius, Martin Zens, Rainer Schmelzeisen, Marc Christian Metzger
MatrixMANDIBLE Preformed Reconstruction Plates (MMPRPs) were developed to overcome laborious bending procedures of conventional reconstruction plates. The design comprises three sizes with a nonbendable centerpiece and two bendable sections (proximal and distal). According to the surgical protocol unnecessary parts are trimmed after the last used screw hole. In the present retrospective study postoperative radiographs from 130 patients (average age 63 years) that received treatment with MMPRPs were assessed...
June 5, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28800664/outcomes-of-cranioplasty-with-preformed-titanium-versus-freehand-molded-polymethylmethacrylate-implants
#4
Julius Höhne, Korbinian Werzmirzowsky, Christian Ott, Christoph Hohenberger, Bahaa Ghareb Hassanin, Alexander Brawanski, Karl-Michael Schebesch
No abstract text is available yet for this article.
August 11, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28799215/secondary-structure-and-dynamics-study-of-the-intrinsically-disordered-silica-mineralizing-peptide-p5-s3-during-silicic-acid-condensation-and-silica-decondensation
#5
Christian Zerfaß, Garry W Buchko, Wendy J Shaw, Stephan Hobe, Harald Paulsen
The silica forming repeat R5 of sil1 from Cylindrotheca fusiformis was the blueprint for the design of P5 S3 , a 50-residue peptide which can be produced in large amounts by recombinant bacterial expression. It contains five protein kinase A target sites and is highly cationic due to 10 lysine and 10 arginine residues. In the presence of supersaturated orthosilicic acid P5 S3 enhances silica-formation whereas it retards the dissolution of amorphous silica (SiO2 ) at globally undersaturated concentrations. The secondary structure of P5 S3 during these two processes was studied by circular dichroism (CD) spectroscopy, complemented by nuclear magnetic resonance (NMR) spectroscopy of the peptide in the absence of silicate...
August 11, 2017: Proteins
https://www.readbyqxmd.com/read/28798159/as-cath1-6-novel-cathelicidins-with-potent-antimicrobial-and-immunomodulatory-properties-from-alligator-sinensis-play-pivotal-roles-in-host-antimicrobial-immune-responses
#6
Yan Chen, Shasha Cai, Xue Qiao, Mali Wu, Zhilai Guo, Renping Wang, Yi-Qun Kuang, Haining Yu, Yipeng Wang
Crocodilians are regarded as possessing a powerful immune system. However, the composition and action of the crocodilian immune system have remained unclear until now. Cathelicidins, the principal family of host defense peptides, play pivotal roles in vertebrate immune defense against microbial invasions. However, cathelicidins from crocodilians have not been extensively studied to date. In the present study, six novel cathelicidins (As-CATH1-6) were identified and characterized from the endangered Chinese alligator (Alligator sinensis)...
August 10, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28796831/the-species-origin-of-the-serum-in-the-culture-medium-influences-the-in-vitro-toxicity-of-silica-nanoparticles-to-hepg2-cells
#7
Cédric Pisani, Estelle Rascol, Christophe Dorandeu, Jean-Charles Gaillard, Clarence Charnay, Yannick Guari, Joël Chopineau, Jean Armengaud, Jean-Marie Devoisselle, Odette Prat
The formation of a protein corona around nanoparticles can influence their toxicity, triggering cellular responses that may be totally different from those elicited by pristine nanoparticles. The main objective of this study was to investigate whether the species origin of the serum proteins forming the corona influences the in vitro toxicity assessment of silica nanoparticles. Coronas were preformed around nanoparticles before cell exposures by incubation in fetal bovine (FBS) or human (HS) serum. The compositions of these protein coronas were assessed by nano-LC MS/MS...
2017: PloS One
https://www.readbyqxmd.com/read/28795889/use-of-an-engineered-honey-to-eradicate-preformed-biofilms-of-important-wound-pathogens-an-in-vitro-study
#8
F D Halstead, M A Webber, B A Oppenheim
OBJECTIVE: We previously reported on the ability of SurgihoneyRO (SHRO), an engineered honey, to prevent biofilm formation in vitro, but data were lacking regarding the activity against preformed biofilms. This study aims to assess whether SHRO has any antibacterial activity against mature, preformed biofilms and whether there is any evidence to support the observed clinical effectiveness when SHRO has been used anecdotally on acute and chronic wounds where biofilm is most likely present...
August 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28794952/potassium-ion-selective-fluorescent-sensors-to-detect-cereulide-the-emetic-toxin-of-b-%C3%A2-cereus-in-food-samples-and-hela-cells
#9
José García-Calvo, Saturnino Ibeas, Eva-Clara Antón-García, Tomás Torroba, Gerardo González-Aguilar, Wilson Antunes, Eloísa González-Lavado, Mónica L Fanarraga
We report the development of new chemical probes for cereulide, a toxic metabolite produced by specific strains of Bacillus cereus, through displacement of potassium cations from a preformed specific complex and a subsequent change in the fluorescence emission. For this purpose, we designed fluorescent probes for potassium cations that were suitable for displacement assays with cereulide from organic extracts. The fluorescence detection of natural cereulide in rice samples was achieved by using synthetic cereulide as a reference and a potassium fluorescent reporter, and this was found to be useful as a portable and fast method for the in situ detection of cereulide in food extracts...
August 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28792661/multi-effect-of-the-water-soluble-moringa-oleifera-lectin-against-serratia-marcescens-and-bacillus-sp-antibacterial-antibiofilm-and-anti-adhesive-properties
#10
M C Moura, D S Trentin, T H Napoleão, M Primon Barros, A S Xavier, N P Carneiro, P M G Paiva, A J Macedo, L C B B Coelho
AIMS: To evaluate the antibiofilm potential of water-soluble Moringa oleifera seed lectin (WSMoL) on Serratia marcescens and Bacillus sp. METHODS AND RESULTS: WSMoL inhibited biofilm formation by S. marcescens at concentrations lower than 2.6 μg ml(-1) and impaired bacterial growth at higher concentrations, avoiding biofilm formation. For Bacillus sp., the lectin inhibited bacterial growth at all concentrations. The antibiofilm action of WSMoL is associated with damage to bacterial cells...
August 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28791754/endothelial-precursor-cells-stimulate-pericyte-like-coverage-of-bone-marrow-derived-mesenchymal-stem-cells-through-pdgf-bb-induction-which-is-enhanced-by-substance-p
#11
Mingzi Zhang, Woosung Ahn, Sumin Kim, Hyun Sook Hong, Chengshi Quan, Youngsook Son
OBJECTIVE: The aim of this study was to evaluate the angiogenicity of a combination of bone marrow-derived endothelial precursor cells (BM-EPCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) in vitro in the presence of substance P (SP), and its working mechanism. METHODS: BM-MSCs and BM-EPCs were co-cultured with or without SP. ELISA and RT-PCR were performed to detect angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF-BB)...
August 8, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28790820/effect-of-the-nanoformulation-of-sirna-lipid-assemblies-on-their-cellular-uptake-and-immune-stimulation
#12
Kohei Kubota, Kohei Onishi, Kazuaki Sawaki, Tianshu Li, Kaoru Mitsuoka, Takaaki Sato, Shinji Takeoka
Two lipid-based nanoformulations have been used to date in clinical studies: lipoplexes and lipid nanoparticles (LNPs). In this study, we prepared small interfering RNA (siRNA)-loaded carriers using lipid components of the same composition to form molecular assemblies of differing structures, and evaluated the impact of structure on cellular uptake and immune stimulation. Lipoplexes are electrostatic complexes formed by mixing preformed cationic lipid liposomes with anionic siRNA in an aqueous environment, whereas LNPs are nanoparticles embedding siRNA prepared by mixing an alcoholic lipid solution with an aqueous siRNA solution in one step...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28790818/peptide-modified-nanoparticles-inhibit-formation-of-porphyromonas-gingivalis-biofilms-with-streptococcus-gordonii
#13
Paridhi Kalia, Ankita Jain, Ranjith Radha Krishnan, Donald R Demuth, Jill M Steinbach-Rankins
PURPOSE: The interaction of Porphyromonas gingivalis with commensal streptococci promotes P. gingivalis colonization of the oral cavity. We previously showed that a synthetic peptide (BAR) derived from Streptococcus gordonii potently inhibited the formation of P. gingivalis/S. gordonii biofilms (IC50 =1.3 µM) and reduced P. gingivalis virulence in a mouse model of periodontitis. Thus, BAR represents a novel therapeutic to control periodontitis by limiting P. gingivalis colonization of the oral cavity...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28789967/protein-glycosylation-in-viral-hepatitis-related-hcc-characterization-of-heterogeneity-biological-roles-and-clinical-implications
#14
Shu Zhang, Xinyi Cao, Qiang Gao, Yinkun Liu
Protein glycosylation is one of the most frequent and well-known posttranslational modifications, playing important roles in physiopathological processes. Glycosylation is catalyzed by enzymatic additions of heterogeneous glycans with specific linkage of monosaccharides and, in a preformed fashion, to specific amino acids within glycoproteins. Altered glycan macroheterogeneity and microheterogeneity have been reported in glycoproteins produced mainly by the liver, facilitating tumorigenesis, progression, and metastasis...
August 5, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28789826/zika-virus-protease-an-antiviral-drug-target
#15
REVIEW
CongBao Kang, Thomas H Keller, Dahai Luo
The recent outbreak of Zika virus (ZIKV) infection has caused global concern due to its link to severe damage to the brain development of foetuses and neuronal complications in adult patients. A worldwide research effort has been undertaken to identify effective and safe treatment and vaccination options. Among the proposed viral and host components, the viral NS2B-NS3 protease represents an attractive drug target due to its essential role in the virus life cycle. Here, we outline recent progress in studies on the Zika protease...
August 5, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28782731/ag-au-pt-trimetallic-nanoparticles-with-defects-preparation-characterization-and-electrocatalytic-activity-in-methanol-oxidation
#16
Kontee Thongthai, Phakkhananan Pakawanit, Narong Chanlek, Jun-Hyun Kim, Supon Ananta, Laongnuan Srisombat
Two series of Agx/Au/Pty trimetallic nanoparticles (AgxAu1Pt2 with x ranging from 1 to 5 and Ag4Au1Pty with y ranging from 1 to 3) were prepared by a sequential chemical reduction method that involved the deposition of Pt on preformed Ag/Au core-shell particles by systematically controlling the amount of Ag, Au, and Pt metal precursor solutions. The structural changes (the diameters and increased surface roughness from the defective features) and absorption patterns (the significant reduction of the peak intensities) of the nanoparticles examined with TEM and UV-Vis spectroscopy indicated the selective incorporation of Pt on the Ag/Au nanoparticles regardless of their compositions...
August 7, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28782023/a-viral-scaffolding-protein-triggers-portal-ring-oligomerization-and-incorporation-during-procapsid-assembly
#17
Tina Motwani, Ravi K Lokareddy, Carmen A Dunbar, Juliana R Cortines, Martin F Jarrold, Gino Cingolani, Carolyn M Teschke
Most double-stranded DNA viruses package genetic material into empty precursor capsids (or procapsids) through a dodecameric portal protein complex that occupies 1 of the 12 vertices of the icosahedral lattice. Inhibiting incorporation of the portal complex prevents the formation of infectious virions, making this step an excellent target for antiviral drugs. The mechanism by which a sole portal assembly is selectively incorporated at the special vertex is unclear. We recently showed that, as part of the DNA packaging process for bacteriophage P22, the dodecameric procapsid portal changes conformation to a mature virion state...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28773821/transverse-crack-detection-in-3d-angle-interlock-glass-fibre-composites-using-acoustic-emission
#18
Matthieu Gresil, Mohamed Nasr Saleh, Constantinos Soutis
In addition to manufacturing cost and production rates, damage resistance has become a major issue for the composites industry. Three-dimensional (3D) woven composites have superior through-thickness properties compared to two-dimensional (2D) laminates, for example, improved impact damage resistance, high interlaminar fracture toughness and reduced notch sensitivity. The performance of 3D woven preforms is dependent on the fabric architecture, which is determined by the binding pattern. For this study, angle interlock (AI) structures with through-thickness binding were manufactured...
August 16, 2016: Materials
https://www.readbyqxmd.com/read/28772977/mechanical-properties-of-nonwoven-reinforced-thermoplastic-polyurethane-composites
#19
Muhammad Tausif, Achilles Pliakas, Tom O'Haire, Parikshit Goswami, Stephen J Russell
Reinforcement of flexible fibre reinforced plastic (FRP) composites with standard textile fibres is a potential low cost solution to less critical loading applications. The mechanical behaviour of FRPs based on mechanically bonded nonwoven preforms composed of either low or high modulus fibres in a thermoplastic polyurethane (TPU) matrix were compared following compression moulding. Nonwoven preform fibre compositions were selected from lyocell, polyethylene terephthalate (PET), polyamide (PA) as well as para-aramid fibres (polyphenylene terephthalamide; PPTA)...
June 5, 2017: Materials
https://www.readbyqxmd.com/read/28772654/optimizing-polymer-infusion-process-for-thin-ply-textile-composites-with-novel-matrix-system
#20
Somen K Bhudolia, Pavel Perrotey, Sunil C Joshi
For mass production of structural composites, use of different textile patterns, custom preforming, room temperature cure high performance polymers and simplistic manufacturing approaches are desired. Woven fabrics are widely used for infusion processes owing to their high permeability but their localised mechanical performance is affected due to inherent associated crimps. The current investigation deals with manufacturing low-weight textile carbon non-crimp fabrics (NCFs) composites with a room temperature cure epoxy and a novel liquid Methyl methacrylate (MMA) thermoplastic matrix, Elium(®)...
March 15, 2017: Materials
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