keyword
MENU ▼
Read by QxMD icon Read
search

Preformance

keyword
https://www.readbyqxmd.com/read/28081035/removal-of-ribonucleotides-by-p53-protein-incorporated-during-dna-synthesis-by-hiv-1-reverse-transcriptase
#1
Tzofit Akua, Galia Rahav, Yossi Saragani, Amnon Hizi, Mary Bakhanashvili
OBJECTIVE(S): HIV-1 reverse transcriptase frequently incorporates ribonucleotides into the proviral DNA in macrophages, but not in lymphocytes. The enzyme exerts an efficient ribonucleotide-terminated primer extension capacity. Furthermore, ribonucleotide-editing repair is attenuated in macrophages. Tumor suppressor p53 protein, displaying an intrinsic 3'→5' exonuclease activity, was found to be involved in efficient proofreading of base-base mismatches produced during DNA synthesis...
January 28, 2017: AIDS
https://www.readbyqxmd.com/read/28076957/collapse-precedes-folding-in-denaturant-dependent-assembly-of-ubiquitin
#2
Govardhan Reddy, Dave Thirumalai
The folding of small protein Ubiquitin (Ub), which plays an indispensable role in targeting proteins for degradation and DNA damage response is complex. A number of experiments on Ub folding have reached differing conclusions regarding the relation between collapse and folding, and whether intermediates are populated. In order to resolve these vexing issues, we elucidate the denaturant-dependent thermodynamics and kinetics of Ub folding at low and neutral pH as a function of Guanidinium chloride and Urea using coarse-grained molecular simulations...
January 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28074646/differences-in-protein-concentration-dependence-for-nucleation-and-elongation-in-light-chain-amyloid-formation
#3
Luis Miguel Blancas-Mejía, Pinaki Misra, Marina Ramirez-Alvarado
Light chain (AL) amyloidosis is a lethal disease characterized by the deposition of the immunoglobulin light chain into amyloid fibrils, resulting in organ dysfunction and failure. Amyloid fibrils have the ability to self-propagate recruiting soluble protein into the fibril by a nucleation-polymerization mechanism, characteristic of auto-catalytic reactions. Experimental data suggest the existence of a critical concentration to initiate fibril formation. As such, the initial concentration of soluble amyloidogenic protein is expected to have a profound effect on the rate of fibril formation...
January 11, 2017: Biochemistry
https://www.readbyqxmd.com/read/28074639/colloidal-synthesis-of-ch3-nh3-pbbr3-nanoplatelets-with-polarized-emission-through-self-organization
#4
Lige Liu, Sheng Huang, Longfei Pan, Li-Jie Shi, Bingsuo Zou, Luogen Deng, Haizheng Zhong
We report a combined experimental and theoretical study of the synthesis of CH3 NH3 PbBr3 nanoplatelets through self-organization. Shape transformation from spherical nanodots to square or rectangular nanoplatelets can be achieved by keeping the preformed colloidal nanocrystals at a high concentration (3.5 mg mL(-1) ) for 3 days, or combining the synthesis of nanodots with self-organization. The average thickness of the resulting CH3 NH3 PbBr3 nanoplatelets is similar to the size of the original nanoparticles, and we also noticed several nanoplatelets with circular or square holes, suggesting that the shape transformation experienced a self-organization process through dipole-dipole interactions along with a realignment of dipolar vectors...
January 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28069496/probiotic-e-coli-nissle-1917-biofilms-on-silicone-substrates-for-bacterial-interference-against-pathogen-colonization
#5
Quan Chen, Zhiling Zhu, Jun Wang, Analette I Lopez, Siheng Li, Amit Kumar, Fei Yu, Haoqing Chen, Chengzhi Cai, Lijuan Zhang
: Bacterial interference is an alternative strategy to fight against device-associated bacterial infections. Pursuing this strategy, a non-pathogenic bacterial biofilm is used as a live, protective barrier to fence off pathogen colonization. In this work, biofilms formed by probiotic Escherichia coli strain Nissle 1917 (EcN) are investigated for their potential for long-term bacterial interference against infections associated with silicone-based urinary catheters and indwelling catheters used in the digestive system, such as feeding tubes and voice prostheses...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28069262/advanced-modeling-reconciles-counterintuitive-decisions-in-lead-optimization
#6
REVIEW
Ariel Fernández, L Ridgway Scott
Lead optimization (LO) is essential to fulfill the efficacy and safety requirements of drug-based targeted therapy. The ease with which water may be locally removed from around the target protein crucially influences LO decisions. However, inferred binding sites often defy intuition and the resulting LO decisions are often counterintuitive, with nonpolar groups in the drug placed next to polar groups in the target. We first introduce biophysical advances to reconcile these apparent mismatches. We incorporate three-body energy terms that account for the net stabilization of preformed target structures upon removal of interfacial water concurrent with drug binding...
January 6, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28063003/effect-of-poly-l-arginine-in-inhibiting-scrapie-prion-protein-of-cultured-cells
#7
Muhammad Waqas, Hye-Mi Lee, Jeeyoung Kim, Glenn Telling, Jin-Ki Kim, Dae-Hwan Kim, Chongsuk Ryou
Biological effect of poly-L-arginine (PLR), the linear homopolymer comprised of L-arginine, was investigated to determine the activity of suppressing prions. PLR decreased the level of scrapie prion protein (PrP(Sc)) in cultured cells permanently infected with prions in a concentration-dependent manner. The PrP(Sc) inhibition efficacy of PLR was greater than that of another prion-suppressant poly-L-lysine (PLK) in a molecular mass-dependent fashion. The effective concentration of PLR to inhibit prions was achieved safely below the cytotoxic concentrations, and overall cytotoxicity of PLR was similar to that of PLK...
January 7, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28060072/zone-i-of-tear-microdesiccates-is-a-lipid-containing-structure
#8
Felipe Traipe, Leonidas Traipe, Daniela Salinas-Toro, Daniela López, Felipe Valenzuela, Claudio Pérez, Cristian Cartes, Francisca Zuazo, Patricia Varela, Héctor Toledo-Araya, Remigio López-Solís
PURPOSE: Morphological features of tear microdesiccates on glass surfaces have been associated with tear fluid status. Tear-film lipids play a critical role in the pathophysiology of some ocular surface disorders. Tear microdesiccates display 4 distinctive morphological domains (zones I, II, III, and transition band). In this study, we investigated the lipid location in tear microdesiccates. METHODS: Tear from individual healthy eyes (assessed by symptoms, signs, and slit-lamp examination) was collected using absorbing minisponges...
February 2017: Cornea
https://www.readbyqxmd.com/read/28059206/spatial-division-multiplexed-brillouin-distributed-sensing-based-on-a-heterogeneous-multicore-fiber
#9
Zhiyong Zhao, Yunli Dang, Ming Tang, Borui Li, Lin Gan, Songnian Fu, Huifeng Wei, Weijun Tong, Ping Shum, Deming Liu
We have experimentally investigated spatial-division multiplexed (SDM) Brillouin optical time-domain analysis in a heterogeneous multicore fiber whose central core and six outer cores are made from different preforms, showing a ∼70  MHz Brillouin frequency shift (BFS) difference between them. It reveals that the heterogeneous central core and the outer cores have different temperature sensitivities, but their strain sensitivities are almost the same. By making use of the distinct temperature coefficients of these two kinds of cores, simultaneous and discriminative temperature and strain measurements are achieved...
January 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28058219/impact-of-preformed-donor-specific-antibodies-against-hla-class-i-on-kidney-graft-outcomes-comparative-analysis-of-exclusively-anti-cw-vs-anti-a-and-or-b-antibodies
#10
Sofia Santos, Jorge Malheiro, Sandra Tafulo, Leonídio Dias, Rute Carmo, Susana Sampaio, Marta Costa, Andreia Campos, Sofia Pedroso, Manuela Almeida, La Salete Martins, Castro Henriques, António Cabrita
AIM: To analyze the clinical impact of preformed antiHLA-Cw vs antiHLA-A and/or -B donor-specific antibodies (DSA) in kidney transplantation. METHODS: Retrospective study, comparing 12 patients transplanted with DSA exclusively antiHLA-Cw with 23 patients with preformed DSA antiHLA-A and/or B. RESULTS: One year after transplantation there were no differences in terms of acute rejection between the two groups (3 and 6 cases, respectively in the DSA-Cw and the DSA-A-B groups; P = 1)...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28044248/the-opinion-of-children-and-their-parents-about-four-different-types-of-dental-restorations-in-a-public-health-service-in-brazil
#11
R Maciel, D Salvador, K Azoubel, R Redivivo, C Maciel, C da Franca, E Amerongen, V Colares
AIM: To investigate the opinion of children and their parents of four different types of restoration placed in primary molars. METHODS: A mixed method study in which both children and their parents were involved. In the quantitative study, children and parents gave their opinion using a face scale about four different types of restoration immediately after placement, evaluating how satisfied they were. In the qualitative part, children and their parents were interviewed to report their preference among the four types of restoration using dental models and photos...
January 2, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28042445/guided-bone-regeneration-via-a-preformed-titanium-foil-clinical-histological-and-histomorphometric-outcome-of-a-case-series
#12
M Andreasi Bassi, C Andrisani, S Lico, Z Ormanier, L Ottria, M Gargari
PURPOSE: The aim of this paper was to evaluate the histological and histomorphometric outcome of Preformed Titanium Foil (PTF) to perform Guided Bone Regeneration (GBR) in posterior mandibular atrophies. MATERIALS AND METHODS: 10 subjects (1 male; 9 females; mean age 58±11.37 years), with distal mandibular atrophies were selected to perform GBR by means of PTF, using a moldable allograft paste as graft material. The devices, made of a 0,2 mm thick pure titanium foil, were pre-shaped using stereolithographic models obtained from CT-scan of the patients' recipient site...
October 2016: Oral & Implantology
https://www.readbyqxmd.com/read/28042444/endoscopic-management-of-the-schneiderian-membrane-perforation-during-transcrestal-sinus-augmentation-a-case-report
#13
M Andreasi Bassi, C Andrisani, S Lico, Z Ormanier, A Barlattani, L Ottria
PURPOSE: In this article the Authors describe a procedure aimed to restore under endoscopic control, the continuity, of the Schneiderian membrane (SM) incidentally teared during a sinus lift with transcrestal approach. MATERIALS E METHODS: In a 44-year-old male, due to aforementioned complication, the SM was gently detached via transcrestal approach, with a customized small ball burnisher, in order to facilitate the placement of a collagen sponge, to close the communication with the sinus, followed by the subsequent insertion of a graft material...
October 2016: Oral & Implantology
https://www.readbyqxmd.com/read/28038883/orbital-fracture-repair-outcomes-with-preformed-titanium-mesh-implants-and-comparison-to-porous-polyethylene-coated-titanium-sheets
#14
Michelle Y Peng, Shannath L Merbs, Michael P Grant, Nicholas R Mahoney
BACKGROUND: Restoration of orbital volume after internal orbital fractures can prevent enophthalmos. A variety of allografts are commonly used including titanium mesh with and without porous polyethylene coating. Some controversy exists over the use of uncoated titanium mesh in the orbit. Newer products contoured to the three dimensional orbital anatomy aim to improve reestablishment of the complex orbital shape though studies of outcomes with their use are limited. METHODS: A retrospective chart review was performed to evaluate surgical outcomes in all patients who underwent orbital fracture repair with DePuy/Synthes titanium MatrixMIDFACE prefabricated implants (PFTi) as compared with porous polyethylene/titanium hybrid implants (PPETi) including Stryker Medpor Titan, MTB, and BTB implants...
December 3, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28038736/-bone-cement-implant-as-an-alternative-for-orbital-floor-reconstruction-a-case-report
#15
Enrique Vargas-Solalinde, Marisol E Huichapa-Padilla, Daniel Garza-Cantú, Víctor H Reyna-Martínez, Julio Alatorre-Ricardo, Juan Luis González-Treviño
BACKGROUND: The management of orbitary fractures is one of the most challenging in facial trauma; the variety of reconstruction materials for its treatment is broad and is constantly improving, but despite this there is no consensus for its use or literature that sustains it. OBJECTIVE: To present the use and design of a preformed bone implant as an alternative for the reconstruction of orbital floor fractures in the pediatric age group. CLINICAL CASE: A 7-year old male who suffered a right hemifacial contusion trauma with clinical and tomographic diagnosis of right pure blowout type orbital floor fracture with inferior rectus muscle entrapment and right post-traumatic palpebral ptosis...
December 27, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28038426/oxidized-epigallocatechin-gallate-inhibited-lysozyme-fibrillation-more-strongly-than-the-native-form
#16
Ting-Ting An, Shuang Feng, Cheng-Ming Zeng
Epigallocatechin gallate (EGCG), the most abundant flavanoid in green tea, is currently being evaluated in the clinic due to its benefits in the treatment of amyloid disorders. Its anti-amyloidogenic effect has been attributed to direct interaction of the intact molecule with misfolded polypeptides. In addition, antioxidant activity is also involved in the anti-amyloidogenic role. The detailed molecular mechanism is still unclear and requires further investigation. In the present study, the kinetics of EGCG oxidation and the anti-amyloidogenic effect of the resultant oxidation substances have been examined...
December 21, 2016: Redox Biology
https://www.readbyqxmd.com/read/28036165/scale-activity-relationship-of-mnox-feoy-nanocage-catalysts-derived-from-prussian-blue-analogues-for-low-temperature-no-reduction-experimental-and-dft-studies
#17
Lijun Yan, Yangyang Liu, Kaiwen Zha, Hongrui Li, Liyi Shi, Dengsong Zhang
Size effects have been recognized to promote the catalytic activity and selectivity of metal oxide particles. So far, limited works and studies are conducted to investigate the size effect of metal oxide with the tailored shape in the selective catalytic reduction of NOx with NH3 (NH3-SCR). Herein, the MnOx-FeOy nanocage catalysts with varied scales (0.25, 0.5, 1, and 2 μm) were synthesized via a Prussian blue analogue (PBA)-derived method and used for NH3-SCR of NO. By preforming a series of the activity tests over the nanocages with different scales, the NH3-SCR activity of 0...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28032100/high-insecticides-resistance-in-culex-pipiens-diptera-culicidae-from-tehran-capital-of-iran
#18
Yaser Salim-Abadi, Mohammad Ali Oshaghi, Ahmad Ali Enayati, Mohammad Reza Abai, Hassan Vatandoost, Mohammad Reza Eshraghian, Hossein Mirhendi, Ahmad Ali Hanafi-Bojd, Mohammad Amin Gorouhi, Fatemeh Rafi
BACKGROUND: During recent years transmission of Dirofilaria immitis (dog heart worm) by Culex pipiens and West Nile virus have been reported from Iran. The present study was preformed for evaluating the susceptibility status of Cx. pipiens collected from capital city of Tehran, Iran. METHODS: Four Insecticides including: DDT 4%, Lambdacyhalothrin 0.05%, Deltamethrin 0.05% and Cyfluthrin 0.15 % according to WHO standard methods were used for evaluating the susceptibility status of Cx...
December 2016: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/28029247/enhancing-the-catalytic-activity-of-zn-containing-magnetic-oxides-in-a-methanol-synthesis-identifying-the-key-factors
#19
Nicholas Baird, Jasper W Dittmar, Yaroslav B Losovyj, David Gene Morgan, Barry D Stein, Maren Pink, Nina V Kuchkina, Elena S Serkova, Olga L Lependina, Maxim E Grigoriev, Alexander I Sidorov, Mikhail G Sulman, Zinaida B Shifrina, Lyudmila M Bronstein
A new family of Ni-, Co-, and Cr-doped Zn-containing magnetic oxide nanoparticles (NPs) stabilized by polyphenylquinoxaline (PPQ) and hyperbranched pyridylphenylene polymer (PPP) has been developed. These NPs have been synthesized by thermal decomposition of Zn and doping metal acetylacetonates in the reaction solution of preformed magnetite NPs, resulting in single-crystal NPs with spinel structure. For the PPQ-capped NPs, it was demonstrated that all three types of metal species (Fe, Zn, and a doping metal) reside within the same NPs, the surface of which is enriched with Zn and a doping metal, while the deeper layers are enriched with Fe...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28026966/facet-selective-growth-of-organic-heterostructured-architectures-via-sequential-crystallization-of-structurally-complementary-%C3%AF-conjugated-molecules
#20
Yilong Lei, Yanqiu Sun, Liangsheng Liao, Shuit-Tong Lee, Wai-Yeung Wong
In contrast to those for their polymeric counterparts, the controlled construction of organic heterostructured architectures derived from π-conjugated organic molecules has been rare and remains a great challenge. Herein, we develop a simple single-step solution strategy for the realization of organic heterostructures comprising coronene and perylene. Under a sequential crystallization process, an efficient doping step for coronene and perylene domains enables their perfect lattice matching, which facilitates facet-selective epitaxial growth of perylene domains on both the tips and the side surfaces of the preformed seed microwires by manipulating the growth pathways of the two pairs of materials...
January 3, 2017: Nano Letters
keyword
keyword
45413
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"