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https://www.readbyqxmd.com/read/28226607/fall-risk-probability-estimation-based-on-supervised-feature-learning-using-public-fall-datasets
#1
Gregory A Koshmak, Maria Linden, Amy Loutfi, Gregory A Koshmak, Maria Linden, Amy Loutfi, Gregory A Koshmak, Maria Linden
Risk of falling is considered among major threats for elderly population and therefore started to play an important role in modern healthcare. With recent development of sensor technology, the number of studies dedicated to reliable fall detection system has increased drastically. However, there is still a lack of universal approach regarding the evaluation of developed algorithms. In the following study we make an attempt to find publicly available fall datasets and analyze similarities among them using supervised learning...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226530/low-rank-magnetic-resonance-fingerprinting
#2
Gal Mazor, Lior Weizman, Assaf Tal, Yonina C Eldar, Gal Mazor, Lior Weizman, Assaf Tal, Yonina C Eldar, Gal Mazor, Assaf Tal, Lior Weizman, Yonina C Eldar
Magnetic Resonance Fingerprinting (MRF) is a relatively new approach that provides quantitative MRI using randomized acquisition. Extraction of physical quantitative tissue values is preformed off-line, based on acquisition with varying parameters and a dictionary generated according to the Bloch equations. MRF uses hundreds of radio frequency (RF) excitation pulses for acquisition, and therefore high under-sampling ratio in the sampling domain (k-space) is required. This under-sampling causes spatial artifacts that hamper the ability to accurately estimate the quantitative tissue values...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220399/leibniz-the-microscope-and-the-concept-of-preformation
#3
Alessandro Becchi
In recent years a certain emphasis has been put by some scholars on Leibniz's concern about empirical sciences and the relations between such concern and the development of his mature metaphysical system. In this paper I focus on Leibniz's interest for the microscope and the astonishing discoveries that such instrument made possible in the field of the life sciences during the last part of the Seventeenth century. The observation of physical bodies carried out by the "magnifying glasses" revealed a matter swarming everywhere with life and activity, contrary to the cartesian and atomistic view of matter as something sterile and passive...
March 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/28219056/anticaries-potential-of-a-sodium-monofluorophosphate-dentifrice-containing-calcium-sodium-phosphosilicate-exploratory-in-situ-randomized-trial
#4
Charles R Parkinson, Muhammad Siddiqi, Stephen Mason, Frank Lippert, Anderson T Hara, Domenick T Zero
Calcium sodium phosphosilicate (CSPS) is a bioactive glass material that alleviates dentin hypersensitivity and is postulated to confer remineralization of caries lesions. This single-centre, randomized, single (investigator)-blind, placebo-controlled, crossover, in situ study explored whether the addition of 5% CSPS to a nonaqueous fluoride (F) such as sodium monofluorophosphate (SMFP)-containing dentifrice affects its cariostatic ability. Seventy-seven subjects wore 4 gauze-covered enamel specimens with preformed lesions (2 surface-softened and 2 subsurface) placed buccally on their mandibular bilateral dentures for up to 4 weeks...
February 21, 2017: Caries Research
https://www.readbyqxmd.com/read/28218465/compliance-with-national-guidelines-on-isotretinoin-where-are-we-2-years-since-the-last-audit-results-of-the-national-isotretinoin-re-audit-2014
#5
L S Exton, S T Cheung, A G Brain, M F Mohd Mustapa, D A R de Berker
BACKGROUND: In 2010, the British Association of Dermatologists (BAD) published clinical guidelines for the safe introduction and continued use of isotretinoin in patients with acne in the UK. The BAD provides UK dermatologists with a facility for national audit, and it undertook an audit on compliance with these guidelines in 2012. AIM: To determine current clinical practices relating to use of isotretinoin among dermatologists in the UK (including geographical variations) as measured against BAD standards, and to ascertain any improvement since the 2012 audit...
February 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28218376/relationship-between-femoral-offset-and-dislocation-in-preformed-antibiotic-loaded-cement-spacers-spacer-g%C3%A2
#6
Ignacio Molinas, Ester Garcia-Oltra, Jenaro A Fernández-Valencia, Xavier Tomas, Xavier Gallart, Josep Riba, Andreu Combalia, Guillem Bori
PURPOSE: A reduction in femoral offset may decrease muscle tension and lead to spacer dislocations even though proximal femur, musculature and acetabulum remain intact. In this study, we aimed to determine whether postoperative lateral femoral offset (LFO) and modified vertical femoral offset (MVFO) values affect the risk of dislocation of a hip spacer. MATERIALS AND METHODS: We measured LFO and MVFO in properly centred, postoperative, anteroposterior radiographs of the pelvis in 66 patients (71 spacers)...
February 8, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28216793/final-report-on-the-key-comparison-ccm-p-k4-2012-in-absolute-pressure-from-1-pa-to-10-kpa
#7
Jacob Ricker, Jay Hendricks, Thomas Bock, Pražák Dominik, Tokihiko Kobata, Jorge Torres, Irina Sadkovskaya
The report summarizes the Consultative Committee for Mass (CCM) key comparison CCM.P-K4.2012 for absolute pressure spanning the range of 1 Pa to 10 000 Pa. The comparison was carried out at six National Metrology Institutes (NMIs), including National Institute of Standards and Technology (NIST), Physikalisch-Technische Bundesanstalt (PTB), Czech Metrology Institute (CMI), National Metrology Institute of Japan (NMIJ), Centro Nacional de Metrología (CENAM), and DI Mendeleyev Institute for Metrology (VNIIM). The comparison was made via a calibrated transfer standard measured at each of the NMIs facilities using their laboratory standard during the period May 2012 to September 2013...
2017: Metrologia
https://www.readbyqxmd.com/read/28207544/tser-polymorphism-is-not-associated-with-risk-of-pediatric-acute-lymphoblastic-leukemia-a-meta-analysis
#8
Zhaohua Qiao, Dan Lou, Li Ruan
BACKGROUND: Accumulating studies have explored the effect of thymidylate synthase enhancer region (TSER) variation on risk of pediatric acute lymphoblastic leukemia (ALL) with controversial results. Therefore, this quantitative meta-analysis was performed to assess synthetically the association of TSER variation with susceptibility to develop pediatric ALL. METHODS: The PubMed, ScienceDirect, Google Scholar, Wanfang Database, and China National Knowledge Infrastructure were systematically retrieved to obtain the published case-control studies about the relationship between TSER variation and pediatric ALL risk...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28206929/disparities-in-mangement-of-patients-with-benign-colorectal-disease-impact-of-urbanization-and-specialized-care
#9
Viraj Pandit, Mazhar Khalil, Bellal Joseph, Jana Jandova, Tahereh Orouji Jokar, Ansab Abbas Haider, Bardiya Zangbar, Asad Asim, Ahmed Hassan, Valentine Nfonsam
: Disparities in the management of patients with various medical conditions are well established. Colorectal diseases continue to remain one of the most common causes for surgical intervention. The aim of this study was to assess disparities (rural versus urban) in the surgical management of patients with noncancerous benign colorectal diseases. We hypothesized that there is no difference among rural versus urban centers (UC) in the surgical management for noncancerous benign colorectal diseases...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28206688/palladium-mediated-arylation-of-lysine-in-unprotected-peptides
#10
Hong Geun Lee, Guillaume Lautrette, Bradley L Pentelute, Stephen L Buchwald
A mild method for the arylation of lysine in an unprotected peptide is presented. In the presence of a preformed biarylphosphine-supported palladium(II)-aryl complex and a weak base, lysine amino groups underwent C-N bond formation at room temperature. The process generally exhibited high selectivity for lysine over other amino acids containing nucleophilic side chains and was applicable to the conjugation of a variety of organic compounds, including complex drug molecules, with an array of peptides. Finally, this method was also successfully applied to the formation of cyclic peptides by macrocyclization...
February 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28205138/kant-s-epigenesis-specificity-and-developmental-constraints
#11
Boris Demarest
In this paper, I argue that Kant adopted, throughout his career, a position that is much more akin to classical accounts of epigenesis, although he does reject the more radical forms of epigenesis proposed in his own time, and does make use of preformationist sounding terms. I argue that this is because Kant (1) thinks of what is pre-formed as a species, not an individual or a part of an individual; (2) has no qualm with the idea of a specific, teleological principle or force underlying generation, and conceives of germs and predispositions as specific constraints on such a principle or force...
March 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/28203471/lumbar-scoliosis-combined-lumbar-spinal-stenosis-and-herniation-diagnosed-patient-was-treated-with-u-route-transforaminal-percutaneous-endoscopic-lumbar-discectomy
#12
Binbin Wu, Shaobo Zhang, Qingquan Lian, Haibo Yan, Xianfa Lin, Gonghao Zhan
The objective was to report a case of a 63-year-old man with a history of low back pain (LBP) and left leg pain for 2 years, and the symptom became more serious in the past 5 months. The patient was diagnosed with lumbar scoliosis combined with lumbar spinal stenosis (LSS) and lumbar disc herniation (LDH) at the level of L4-5 that was confirmed using Computerized Topography and Magnetic Resonance Imaging. The surgical team preformed a novel technique, "U" route transforaminal percutaneous endoscopic lumbar discectomy (PELD), which led to substantial, long-term success in reduction of pain intensity and disability...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28203185/reversible-cerebral-vasoconstriction-syndrome-with-intracranial-hypertension-should-decompressive-craniectomy-be-considered
#13
Ségolène Mrozek, Laurent Lonjaret, Aude Jaffre, Anne-Christine Januel, Nicolas Raposo, Sergio Boetto, Jean-François Albucher, Olivier Fourcade, Thomas Geeraerts
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is a rare cause of intracerebral hemorrhage (ICH) causing intracranial hypertension. METHODS: Case report. RESULTS: We report a case of RCVS-related ICH leading to refractory intracranial hypertension. A decompressive craniectomy was performed to control intracranial pressure. We discuss here the management of RCVS with intracranial hypertension. Decompressive craniectomy was preformed to avoid the risky option of high cerebral perfusion pressure management with the risk of bleeding, hemorrhagic complications, and high doses of norepinephrine...
January 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28195706/piezoelectric-micro-and-nanostructured-fibers-fabricated-from-thermoplastic-nanocomposites-using-a-fiber-drawing-technique-comparative-study-and-potential-applications
#14
Xin Lu, Hang Qu, Maksim Skorobogatiy
We report an all-polymer flexible piezoelectric fiber that uses both judiciously chosen geometry and advanced materials in order to enhance fiber piezoelectric response. The microstructured/nanostructured fiber features a soft hollow polycarbonate core surrounded by a spiral multilayer cladding consisting of alternating layers of piezoelectric nanocomposites (polyvinylidene enhanced with BaTiO3, PZT, or CNT) and conductive polymer (carbon-filled polyethylene). The conductive polymer layers serve as two electrodes, and they also form two spatially offset electric connectors on the fiber surface designed for the ease of connectorization...
February 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28193532/age-dependent-atypicalities-in-body-and-face-sensitive-activation-of-the-eba-and-ffa-in-individuals-with-asd
#15
Yuko Okamoto, Hirotaka Kosaka, Ryo Kitada, Ayumi Seki, Hiroki C Tanabe, Masamichi J Hayashi, Takanori Kochiyama, Daisuke N Saito, Hisakazu T Yanaka, Toshio Munesue, Makoto Ishitobi, Masao Omori, Yuji Wada, Hidehiko Okazawa, Tatsuya Koeda, Norihiro Sadato
Individuals with autism spectrum disorder (ASD) have difficuly in recognizing bodies and faces, which are more pronounced in children than adults. If such difficulties originate from dysfunction of the extrastriate body area (EBA) and the fusiform face area (FFA), activation in these regions might be more atypical in children than in adults. We preformed functional magnetic resonance imaging while children and adults with ASD and age-matched typically developed (TD) individuals observed face, body, car, and scene...
February 10, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28179988/ips-derived-mscs-from-an-expandable-bank-to-deliver-a-prodrug-converting-enzyme-that-limits-growth-and-metastases-of-human-breast-cancers
#16
M Ullah, Y Kuroda, T J Bartosh, F Liu, Q Zhao, C Gregory, R Reger, J Xu, R H Lee, D J Prockop
One attractive strategy to treat cancers is to deliver an exogenous enzyme that will convert a non-toxic compound to a highly toxic derivative. The strategy was tested with viral vectors but was disappointing because the efficiency of transduction into tumor cells was too low. Recent reports demonstrated that the limitation can be addressed by using tissue-derived mesenchymal stromal cells (MSCs) to deliver enzyme/prodrug systems that kill adjacent cancer cells through bystander effects. Here we addressed the limitation that tissue-derived MSCs vary in their properties and are difficult to generate in the large numbers needed for clinical applications...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28179456/kinetics-of-milk-lipid-droplet-ld-transport-growth-and-secretion-revealed-by-intravital-imaging-ld-release-is-intermittently-stimulated-by-oxytocin
#17
Andrius Masedunskas, Yun Chen, Rebecca Stussman, Roberto Weigert, Ian H Mather
The lipid droplet (LD) fraction of milk has attracted special attention because it supplies preformed lipids for neonatal development and the assembled LDs are secreted by a unique apocrine mechanism. Because many aspects of this key process remain uncharacterized we developed a facile method for the intravital imaging of mammary cells in transgenic mice, which express fluorescently-tagged marker proteins. Using these techniques, we describe the first kinetic analysis of LD growth and secretion at peak lactation in real time...
February 8, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28177348/nutrient-digestibility-and-milk-production-responses-to-increasing-levels-of-palmitic-acid-supplementation-vary-in-cows-receiving-diets-with-or-without-whole-cottonseed
#18
J E Rico, J de Souza, M S Allen, A L Lock
Our study evaluated the dose-dependent effects of a palmitic acid-enriched supplement in basal diets with or without the inclusion of whole cottonseed on nutrient digestibility and production responses of dairy cows. Sixteen Holstein cows (149 ± 56 days in milk) were used in a split plot Latin square design experiment. Cows were blocked by 3.5% fat-corrected milk (FCM) and allocated to a main plot receiving either a basal diet with soyhulls (SH, = 8) or a basal diet with whole cottonseed (CS, = 8) that was fed throughout the experiment...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28175977/development-and-evaluation-of-a-novel-curved-biopsy-device-for-ct-guided-biopsy-of-lesions-unreachable-using-standard-straight-needle-trajectories
#19
Maximilian Franz Schulze-Hagen, Jochen Pfeffer, Markus Zimmermann, Martin Liebl, Saskia Freifrau von Stillfried, Christiane Kuhl, Philipp Bruners, Peter Isfort
PURPOSE: To evaluate the feasibility of a novel curved CT-guided biopsy needle prototype with shape memory to access otherwise not accessible biopsy targets. METHODS AND MATERIALS: A biopsy needle curved by 90° with specific radius was designed. It was manufactured using nitinol to acquire shape memory, encased in a straight guiding trocar to be driven out for access of otherwise inaccessible targets. Fifty CT-guided punctures were conducted in a biopsy phantom and 10 CT-guided punctures in a swine corpse...
February 7, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28174400/-l-shaped-partial-upper-sternotomy-approach-for-aortic-valve-replacement
#20
Hiroshi Munakata, Noriko Oyama, Yu Murakami, Takahiro Yamazato, Noriyuki Abe, Katsuhito Mabuni, Tadao Kugai
Transcatheter aortic valve implantation is a recent innovation in the treatment of severe aortic stenosis. On the other hand, several reports suggested that minimally invasive aortic valve replacement (MICS-AVR) is likely to be associated with reduced postoperative discomfort and faster recovery. Of note, an upper partial sternotomy for isolated aortic valve replacement( L-shaped MICS-AVR) has been accepted as the most common approach to the MICS-AVR. Since October 2013, we have preformed L-shaped MICS-AVR at our hospital...
February 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
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