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https://www.readbyqxmd.com/read/28534838/electrophilic-trifluoromethylselenolation-of-boronic-acids
#1
Clément Ghiazza, Anis Tlili, Thierry Billard
Trifluoromethylselenylated compounds are emergent compounds with interesting physicochemical properties that still suffer from a lack of efficient synthetic methods. We recently developed an efficient one-pot strategy to generate in situ CF₃SeCl and use it in various reactions. Herein, we continue our study of the reactivity scope of this preformed reagent. Cross-coupling reactions with aromatic and heteroaromatic boronic acids have been investigated. The expected products have been obtained, using a stoichiometric amount of copper, with moderate yields...
May 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28534083/synthetic-alpha-synuclein-fibrils-cause-mitochondrial-impairment-and-selective-dopamine-neurodegeneration-in-part-via-inos-mediated-nitric-oxide-production
#2
Victor Tapias, Xiaoping Hu, Kelvin C Luk, Laurie H Sanders, Virginia M Lee, J Timothy Greenamyre
Intracellular accumulation of α-synuclein (α-syn) are hallmarks of synucleinopathies, including Parkinson's disease (PD). Exogenous addition of preformed α-syn fibrils (PFFs) into primary hippocampal neurons induced α-syn aggregation and accumulation. Likewise, intrastriatal inoculation of PFFs into mice and non-human primates generates Lewy bodies and Lewy neurites associated with PD-like neurodegeneration. Herein, we investigate the putative effects of synthetic human PFFs on cultured rat ventral midbrain dopamine (DA) neurons...
May 22, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28531869/a-rare-case-of-subacute-appendicitis-actinomycosis-as-the-final-pathology-reports-a-case-report-and-literature-review
#3
G A Gómez-Torres, O S Ortega-Gárcia, E G Gutierrez-López, C A Carballido-Murguía, J A Flores-Rios, C R López-Lizarraga, C A Bautista López, C F Ploneda-Valencia
INTRODUCTION: Acute appendicitis is the most common indication for an emergency abdominal surgery in the world, with a lifetime incidence of around 10%. Actinomycetes are the etiology of appendicitis in only 0.02%-0.06%, having as the final pathology report a chronic inflammatory response; less than 10% of the cases are diagnosed before surgery. Here, we present the case of a subacute appendicitis secondary to actinomycosis. CASE REPORT: A 39-year-old male presented with a twelve-day evolution of intermittent abdominal pain in the right lower quadrant, treated at the beginning with ciprofloxacin and urinary analgesic...
May 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28529382/reversibly-manipulating-the-surface-chemistry-of-polymeric-nanostructures-via-a-grafting-to-approach-mediated-by-nucleobase-interactions
#4
Zan Hua, Robert Keogh, Zhen Li, Thomas R Wilks, Guosong Chen, Rachel K O'Reilly
"Grafting to" polymeric nanostructures or surfaces is a simple and versatile approach to achieve functionalization. Herein, we describe the formation of mixed polymer-grafted nanoparticles through a supramolecular "grafting to" method that exploits multiple hydrogen-bonding interactions between the thymine (T)-containing cores of preformed micelles and the complementary nucleobase adenine (A) of added diblock copolymers. To demonstrate this new "grafting to" approach, mixed-corona polymeric nanoparticles with different sizes were prepared by the addition of a series of complementary diblock copolymers containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) to a preformed micelle with a different coronal forming block, poly(4-acryloylmorpholine) (PNAM)...
May 9, 2017: Macromolecules
https://www.readbyqxmd.com/read/28529070/parameters-influencing-the-course-of-passive-drug-loading-into-lipid-nanoemulsions
#5
Katrin Göke, Heike Bunjes
Passive drug loading can be used to effectively identify suitable colloidal lipid carrier systems for poorly water-soluble drugs. This method comprises incubation of preformed carrier systems with drug powder and subsequent determination of the resulting drug load of the carrier particles. Until now, the passive loading mechanism is unknown, which complicates reliable routine use. In this work, the influence of drug characteristics on the course of passive loading was investigated systematically varying drug surface area and drug solubility...
May 18, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28520407/controlling-configurational-isomerism-in-three-component-colloidal-hybrid-nanoparticles
#6
James M Hodges, Raymond E Schaak
Colloidal hybrid nanoparticles are solution-dispersible constructs that join together multiple distinct nanoscale materials through direct solid-solid interfaces. Given their multifunctionality and synergistic properties that emerge from interfacial coupling, hybrid nanoparticles are of interest for applications in biomedical imaging, solar energy conversion, heterogeneous catalysis, nanophotonics, and beyond. High-order hybrid nanoparticles, which incorporate three or more nanocrystal domains, offer greater tunability and functional diversity relative to one or two-component nanoparticles...
May 18, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28517936/in-situ-hydrogel-conditioning-of-tissue-samples-to-enhance-the-drug-s-sensitivity-in-ambient-mass-spectrometry-imaging
#7
Xiaowei Song, Zhigang Luo, Xin Li, Tiegang Li, Zhonghua Wang, Chenglong Sun, Luojiao Huang, Ping Xie, Xiaoyu Liu, Jiuming He, Zeper Abliz
Ion suppression from the tissue matrix has a severe effect on the mass spectrometry imaging (MSI) of drugs. This problem hinders further applications of MSI in preclinical drug research and development. In this study, an in situ hydrogel conditioning method was developed to enhance the sensitivity of air-flow-assisted desorption electrospray ionization (AFADESI)-MSI. Instead of the traditional wash-up or digestion treatment in solvent, this method used a solid phase hydrogel to "wash" tissue sections. It was demonstrated that this in situ hydrogel conditioning method improve the drug signal by as much as 2- to 25-folds in MSI, especially for hydrophobic compounds...
May 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28515715/anti-biofilm-and-antivirulence-activities-of-metabolites-from-plectosphaerella-cucumerina-against-pseudomonas-aeruginosa
#8
Jinwei Zhou, Shiyuan Bi, Hongjuan Chen, Tongtong Chen, Rui Yang, Minghui Li, Yonghong Fu, Ai-Qun Jia
This study reported the efficacy of the metabolites of Plectosphaerella cucumerina, one phyllosphere fungus from Orychophragmus violaceus, against Pseudomonas aeruginosa quorum sensing (QS) and QS-regulated biofilms. The minimum inhibitory concentration (MIC) of the ethyl acetate (EtOAc) extract from P. cucumerina against P. aeruginosa PAO1 was 1.25 mg mL(-1). At sub-MIC concentrations, P. cucumerina extract (0.25-1 mg mL(-1)) not only inhibited biofilm formation but also disrupted preformed biofilms of P. aeruginosa PAO1 without affecting its growth...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28505773/relativistic-laser-hosing-instability-suppression-and-electron-acceleration-in-a-preformed-plasma-channel
#9
T W Huang, C T Zhou, H Zhang, S Z Wu, B Qiao, X T He, S C Ruan
The hosing processes of a relativistic laser pulse, electron acceleration, and betatron radiation in a parabolic plasma channel are investigated in the direct laser acceleration regime. It is shown that the laser hosing instability would result in the generation of a randomly directed off-axis electron beam and radiation source with a large divergence angle. While employing a preformed parabolic plasma channel, the restoring force provided by the plasma channel would correct the perturbed laser wave front and thus suppress the hosing instability...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28501397/effect-of-conjugated-linoleic-acid-and-acetate-on-milk-fat-synthesis-and-adipose-lipogenesis-in-lactating-dairy-cows
#10
N Urrutia, K J Harvatine
During biohydrogenation-induced milk fat depression (MFD), nutrients are spared from milk fat synthesis and are available for other metabolic uses. Acetate is the major carbon source spared and it may increase lipid synthesis in adipose tissue during MFD. The objective of this study was to compare the effect of trans-10, cis-12 conjugated linoleic acid (CLA) and the amount of acetate spared during CLA-induced MFD on adipose tissue lipogenesis. Nine multiparous, lactating, ruminally cannulated Holstein cows (244 ± 107 d in milk; 25 ± 8...
May 10, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28499132/multiple-dictyostelid-species-destroy-biofilms-of-klebsiella-oxytoca-and-other-gram-negative-species
#11
Dean Sanders, Katarzyna D Borys, Fikrullah Kisa, Sheryl A Rakowski, Marcela Lozano, Marcin Filutowicz
Dictyostelids are free-living phagocytes that feed on bacteria in diverse habitats. When bacterial prey is in short supply or depleted, they undergo multicellular development culminating in the formation of dormant spores. In this work, we tested isolates representing four dictyostelid species from two genera (Dictyostelium and Polysphondylium) for the potential to feed on biofilms preformed on glass and polycarbonate surfaces. The abilities of dictyostelids were monitored for three hallmarks of activity: 1) spore germination on biofilms, 2) predation on biofilm enmeshed bacteria by phagocytic cells and 3) characteristic stages of multicellular development (streaming and fructification)...
April 12, 2017: Protist
https://www.readbyqxmd.com/read/28495324/biology-of-the-somatotroph-axis-after-the-pituitary
#12
Ron G Rosenfeld, Vivian Hwa
Normal growth requires that pituitary-secreted growth hormone (GH) bind to its specific receptor and activate a complex signaling cascade, leaving to production of insulin-like growth factor-I (IGF-I), which, in turn, activates its own receptor (IGF1R). The GH receptor (GHR) is preformed as a dimer and is transported in a nonligand bound state to the cell surface. Binding of GH to the GHR dimer, results in a conformational change of the dimer, activation of the intracellular Janus Kinase 2 (JAK2) and phosphorylation of signal transducer and activator of transcription (STAT) 5B...
May 8, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28487997/the-effectiveness-of-anti-biofilm-and-anti-virulence-properties-of-dihydrocelastrol-and-dihydrocelastryl-diacetate-in-fighting-against-methicillin-resistant-staphylococcus-aureus
#13
Seung-Gyun Woo, So-Min Lee, So-Yeon Lee, Kyoung-Hee Lim, Eun-Ju Ha, Sa-Hyun Kim, Yong-Bin Eom
Human pathogens have readily been converted into multidrug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), because of the long-term use of conventional antibiotics. In addition, the biofilms formed by S. aureus cells are especially problematic and are related to the persistence of chronic infections because they constitute a major mechanism of promoting tolerance to diverse antimicrobial agents. Hence, the inhibitions of biofilm formation and/or toxin production are accepted as alternative means of controlling S...
May 9, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28486639/dna-synthesis-determines-the-binding-mode-of-the-human-mitochondrial-single-stranded-dna-binding-protein
#14
José A Morin, Fernando Cerrón, Javier Jarillo, Elena Beltran-Heredia, Grzegorz L Ciesielski, J Ricardo Arias-Gonzalez, Laurie S Kaguni, Francisco J Cao, Borja Ibarra
Single-stranded DNA-binding proteins (SSBs) play a key role in genome maintenance, binding and organizing single-stranded DNA (ssDNA) intermediates. Multimeric SSBs, such as the human mitochondrial SSB (HmtSSB), present multiple sites to interact with ssDNA, which has been shown in vitro to enable them to bind a variable number of single-stranded nucleotides depending on the salt and protein concentration. It has long been suggested that different binding modes might be used selectively for different functions...
May 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28486131/large-cytoplasm-is-linked-to-the-error-prone-nature-of-oocytes
#15
Hirohisa Kyogoku, Tomoya S Kitajima
Chromosome segregation during meiosis in oocytes is error prone. The uniquely large cytoplasmic size of oocytes, which provides support for embryogenesis after fertilization, might be a predisposing factor for meiotic errors. However, this hypothesis remains unproven. Here, we show that cytoplasmic size affects the functionality of the acentrosomal spindle. Artificially decreasing the cytoplasmic size in mouse oocytes allows the acentrosomal spindle poles to have a better-focused distribution of microtubule-organizing centers and to biorient chromosomes more efficiently, whereas enlargement of the cytoplasmic size has the opposite effects...
May 8, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28481447/solvent-geometry-regulated-cooperative-supramolecular-polymerization
#16
Suhrit Ghosh
This article discloses H-bonding driven supramolecular polymerization of a core-substituted naphthalene-diimide derivative NDI-1 which exhibits J-aggregation in all tested hydrocarbon solvents however spontaneous gelation was noticed only in linear alkanes in contrast to free flowing solution in their cyclic analogues. Mechanistic investigation by variable temperature UV/Vis studies and analyzing the data using an appropriate model(s) elucidate a highly cooperative self-assembly pathway in linear hydrocarbons (heptane, octane, nonane or decane) in sharp contrast to cyclohexane or methyl-cyclohexane in which an ill-defined polymerization was noticed...
May 8, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28477360/impact-of-transplant-accessibility-for-sensitized-patients-by-avoiding-unacceptable-antigens
#17
Arnaud Del Bello, Nicolas Congy-Jolivet, Benoit Audry, Corinne Antoine, Laure Esposito, Anne-Laure Hebral, Nassim Kamar
Recent data have confirmed the negative impact of preformed donor-specific antibodies after liver transplantation. In order to reduce the risk of developing lesions associated with acute and chronic antibody-mediated rejection in liver-transplant recipients, we evaluated the consequences in terms of transplant accessibility, associated with avoiding preformed DSAs according to several MFI-titer thresholds that have been previously reported to be relevant in liver transplantation. Among the 484 included LT candidates, 99 (20...
May 6, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28475317/rational-synthesis-of-chiral-metal-organic-frameworks-from-preformed-rodlike-secondary-building-units
#18
Thais Grancha, Xiaoni Qu, Miguel Julve, Jesús Ferrando-Soria, Donatella Armentano, Emilio Pardo
The lack of rational design methodologies to obtain chiral rod-based MOFs is a current synthetic limitation that hampers further expansion of MOF chemistry. Here we report a metalloligand design strategy consisting of the use, for the first time, of preformed 1D rodlike SBUs (1) for the rational preparation of a chiral 3D MOF (2) exhibiting a rare eta net topology. The encoded chiral information on the enantiopure ligand is efficiently transmitted first to the preformed helical 1D building block and, in a second stage, to the resulting chiral 3D MOF...
May 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28475177/the-role-of-hybrid-ubiquitin-chains-in-the-myd88-and-other-innate-immune-signalling-pathways
#19
REVIEW
Philip Cohen, Sam Strickson
The adaptor protein MyD88 is required for signal transmission by toll-like receptors and receptors of the interleukin-1 family of cytokines. MyD88 signalling triggers the formation of Lys63-linked and Met1-linked ubiquitin (K63-Ub, M1-Ub) chains within minutes. The K63-Ub chains, which are formed by the E3 ubiquitin ligases TRAF6, Pellino1 and Pellino2, activate TAK1, the master kinase that switches on mitogen-activated protein (MAP) kinase cascades and initiates activation of the canonical IκB kinase (IKK) complex...
May 5, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28471643/lipostar-a-comprehensive-platform-neutral-cheminformatics-tool-for-lipidomics
#20
Laura Goracci, Sara Tortorella, Paolo Tiberi, Roberto Maria Pellegrino, Alessandra Di Veroli, Aurora Valeri, Gabriele Cruciani
To date, the main limitations for LC-MS-based untargeted lipidomics reside in the lack of adequate computational and cheminfor-matics tools that are able to support the analysis of several thousands of species from biological samples, enabling data mining and automating lipid identification and external prediction processes. To address these issues, we developed Lipostar, a novel vendor-neutral high-throughput software that effectively supports both targeted and untargeted LC-MS lipidomics, implementing data ac-quisition, user-friendly multivariate analysis (to be used for model generation and new sample predictions), and advanced lipid iden-tification protocols that can work with or without the support of preformed lipid databases...
May 4, 2017: Analytical Chemistry
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