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https://www.readbyqxmd.com/read/28918394/apolipoprotein-l1-confers-ph-switchable-ion-permeability-to-phospholipid-vesicles
#1
Jonathan Bruno, Nicola Pozzi, Jonathan Oliva, John C Edwards
Apolipoprotein L1 (ApoL1) is a human serum protein conferring resistance to African trypanosomes, and certain ApoL1 variants increase susceptibility to some progressive kidney diseases. ApoL1 has been hypothesized to function like a pore-forming colicin and been reported to have permeability effects on both intracellular and plasma membranes. Here, to gain insight into how ApoL1 may function in vivo, we used vesicle-based ion-permeability, direct membrane-association, and intrinsic fluorescence to study the activities of purified recombinant ApoL1...
September 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28918150/short-communication-effects-of-lysolecithin-on-milk-fat-synthesis-and-milk-fatty-acid-profile-of-cows-fed-diets-differing-in-fiber-and-unsaturated-fatty-acid-concentration
#2
D E Rico, Y Ying, K J Harvatine
Thirteen multiparous Holstein cows were used in a crossover design that tested the effect of lysolecithin in diets differing in neutral detergent fiber (NDF) and unsaturated fatty acid (FA) concentrations. Experimental periods were 20 d in length and included two 10-d phases. A standard fiber and lower fat diet was fed the first 10 d (30.5% NDF, no added oil, lower-risk phase) and a lower NDF and higher oil diet was fed during the second 10 d (29.0% NDF and 2% oil from whole soybeans and soybean oil, high-risk phase)...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28918091/opposed-effects-of-dityrosine-formation-in-soluble-and-aggregated-%C3%AE-synuclein-on-fibril-growth
#3
Michael M Wördehoff, Hamed Shaykhalishahi, Luca Groß, Lothar Gremer, Matthias Stoldt, Alexander K Buell, Dieter Willbold, Wolfgang Hoyer
Parkinson's disease (PD) is the second most common neurodegenerative disease. It is characterized by aggregation of the protein α-synuclein (α-syn) in Lewy bodies, mitochondrial dysfunction, and increased oxidative stress in the substantia nigra. Oxidative stress leads to several modifications of biomolecules including dityrosine (DiY)-crosslinking in proteins, which has recently been detected in α-syn in Lewy bodies from PD patients. Here we report that α-syn is highly susceptible to UV-induced DiY formation...
September 13, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28917837/memantine-inhibits-%C3%AE-amyloid-aggregation-and-disassembles-preformed-%C3%AE-amyloid-aggregates
#4
Kaori Ito, Mitsuhiro Makino, Keiko Okado, Taisuke Tomita
Memantine, an uncompetitive glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist, is widely used as a medication for the treatment of Alzheimer's disease (AD). We previously reported that chronic treatment of AD with memantine reduces the amount of insoluble β-amyloid (Aβ) and soluble Aβ oligomers in animal models of AD. The mechanisms by which memantine reduces Aβ levels in the brain were evaluated by determining the effect of memantine on Aβ aggregation using thioflavin T and transmission electron microscopy...
September 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28912946/crosslinking-method-of-hyaluronic-based-hydrogel-for-biomedical-applications
#5
Sureerat Khunmanee, Younghyen Jeong, Hansoo Park
In the field of tissue engineering, there is a need for advancement beyond conventional scaffolds and preformed hydrogels. Injectable hydrogels have gained wider admiration among researchers as they can be used in minimally invasive surgical procedures. Injectable gels completely fill the defect area and have good permeability and hence are promising biomaterials. The technique can be effectively applied to deliver a wide range of bioactive agents, such as drugs, proteins, growth factors, and even living cells...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28911099/bacillus-subtilis-reca-with-dpra-ssba-antagonizes-recx-function-during-natural-transformation
#6
Shimin Le, Ester Serrano, Ryo Kawamura, Begoña Carrasco, Jie Yan, Juan C Alonso
Bacillus subtilis DprA and RecX proteins, which interact with RecA, are crucial for efficient chromosomal and plasmid transformation. We showed that RecA, in the rATP·Mg2+ bound form (RecA·ATP), could not compete with RecX, SsbA or SsbB for assembly onto single-stranded (ss)DNA, but RecA·dATP partially displaced these proteins from ssDNA. RecX promoted reversible depolymerization of preformed RecA·ATP filaments. The two-component DprA-SsbA mediator reversed the RecX negative effect on RecA filament extension, but not DprA or DprA and SsbB...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28906399/characteristics-of-infection-and-its-impact-on-short-term-outcome-in-patients-with-acute-on-chronic-liver-failure
#7
Junjun Cai, Mengchen Zhang, Tao Han, Hui-Qing Jiang
Bacterial infections are an important cause of mortality in liver failure. However, the type of infection, predictors of infection, and their impact on outcomes in patients with acute-on-chronic liver failure (ACLF) are limited.A total of 389 patients with ACLF were admitted in this retrospective, corhort study. Once admitted, clinical data including first infection site, type (community-acquired, healthcare-associated, or nosocomial), and second infection occurrence during hospitalization were collected. The outcome was mortality within 90 days...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28905504/is-essential-tremor-a-single-entity
#8
Franziska Hopfner, Günther Deuschl
Essential tremor (ET) is a frequent movement disorder. A new tremor classification has subdivided ET, into the classical form with bilateral action tremor of the hands with or without involvement of further tremor locations and without any other explaining signs or symptoms for the tremor and into 'ET plus' which comes additionally with further neurologic signs of unknown origin. This will provide a better foundation for subclassifying the condition. The immediate cause of ET is a preformed oscillating network within the central nervous system as revealed with electrophysiologic methods...
September 14, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28898953/transfer-of-mercury-and-phenol-derivatives-across-the-placenta-of-baltic-grey-seals-halichoerus-grypus-grypus
#9
Iga Nehring, Agnieszka Grajewska, Lucyna Falkowska, Marta Staniszewska, Iwona Pawliczka, Dominika Saniewska
The placenta is an intermediary organ between the female and the developing foetus. Some chemical substances, including the most harmful ones, exhibit the ability to accumulate in or penetrate through the placenta. The aim of the study was to determine the role of the placenta of the Baltic grey seal (Halichoerus grypus grypus) in the transfer of endocrine disrupting compounds (EDCs) - (bisphenol A, 4-tert- octylphenol, 4- nonylphenol), as well as total and organic mercury. 30 placentas were collected from grey seals pupping under human care at the Hel Marine Station in the years 2007-2016...
September 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28893370/inhibitory-efficacy-of-geraniol-on-biofilm-formation-and-development-of-adaptive-resistance-in-staphylococcus-epidermidis-rp62a
#10
Arunachalam Kannappan, Murugesan Sivaranjani, Ramanathan Srinivasan, Janarthanam Rathna, Shunmugiah Karutha Pandian, Arumugam Veera Ravi
PURPOSE: The current study has been designed to delineate the efficacy of geraniol (GE) on biofilm formation in Staphylococcus epidermidis as well as the effect of subinhibitory concentrations of GE on the development of adaptive resistance. METHODOLOGY: Biofilm biomass quantification assay was performed to evaluate the antibiofilm activity of GE against S. epidermidis. Microscopic observation of biofilms and extracellular polymeric substance (EPS), slime and cell surface hydrophobicity (CSH) production were also studied to support the antibiofilm potential of GE...
September 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28891557/functions-of-tissue-resident-eosinophils
#11
REVIEW
Peter F Weller, Lisa A Spencer
Eosinophils are a prominent cell type in particular host responses such as the response to helminth infection and allergic disease. Their effector functions have been attributed to their capacity to release cationic proteins stored in cytoplasmic granules by degranulation. However, eosinophils are now being recognized for more varied functions in previously underappreciated diverse tissue sites, based on the ability of eosinophils to release cytokines (often preformed) that mediate a broad range of activities into the local environment...
September 11, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28891156/overcoming-pre-existing-alloantibody-in-renal-transplantation-improving-outcomes-while-reducing-need-and-cost
#12
EDITORIAL
A Bentall, Solomon Shlomo J Cohney
In this week's journal, Axelrod and colleagues examine costs incurred by various US centers undertaking Incompatible Live-Donor Kidney Transplantation (ILDKT) - living donor renal transplantation in the presence of preformed antibody (ies) directed against donor HLA (DSAb) [1]. As expected, cost increased as the immunological barrier intensified (as defined by solid phase and cell based assays). While certain aspects of cost recovery are specific to US health care, effectively managing humoral allo-immunity is important to all transplant clinicians, with little progress despite nearly 2 decades of ILDKT [2, 3]...
September 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28890370/a-mechanistic-insight-into-protein-ligand-interaction-folding-misfolding-aggregation-and-inhibition-of-protein-aggregates-an-overview
#13
REVIEW
Tajalli Ilm Chandel, Masihuz Zaman, Mohsin Vahid Khan, Maroof Ali, Gulam Rabbani, Mohd Ishtikhar, Rizwan Hasan Khan
This review article summarises the possible mechanisms of the protein-ligand interaction, folding, misfolding, aggregation and inhibition of protein aggregates. Under certain stressed condition the folding process deviates from its path and results into misfolding and aggregation of proteins. So aggregates have to be inhibited in order to cure the diseases. In some cases of protein-ligand interaction studies we have seen that the interaction of a protein with more than one ligand may show both type of quenching mechanisms i...
September 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28890333/static-and-dynamic-dna-loops-form-ap-1-bound-activation-hubs-during-macrophage-development
#14
Douglas H Phanstiel, Kevin Van Bortle, Damek Spacek, Gaelen T Hess, Muhammad Saad Shamim, Ido Machol, Michael I Love, Erez Lieberman Aiden, Michael C Bassik, Michael P Snyder
The three-dimensional arrangement of the human genome comprises a complex network of structural and regulatory chromatin loops important for coordinating changes in transcription during human development. To better understand the mechanisms underlying context-specific 3D chromatin structure and transcription during cellular differentiation, we generated comprehensive in situ Hi-C maps of DNA loops in human monocytes and differentiated macrophages. We demonstrate that dynamic looping events are regulatory rather than structural in nature and uncover widespread coordination of dynamic enhancer activity at preformed and acquired DNA loops...
September 1, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28888601/interaction-of-potassium-carbonate-and-soybean-oil-supplementation-on-performance-of-early-lactation-dairy-cows-fed-a-high-concentrate-diet
#15
A R Alfonso-Avila, E Baumann, É Charbonneau, P Y Chouinard, G F Tremblay, R Gervais
Potassium carbonate supplementation is known to improve milk fat synthesis and to modify milk mineral composition in dairy cows. The objective of the current experiment was to evaluate the effect of K2CO3 on production performance, biohydrogenation of fatty acids (FA), and mineral composition of milk in early-lactation dairy cows fed a high-concentrate diet with or without soybean oil (SBO), as a source of polyunsaturated FA. Twenty-eight ruminally fistulated Holstein cows were used in a randomized complete block design...
September 6, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28888039/role-of-aldh1-in-the-prognosis-of-esophageal-cancer-and-its-relationship-with-tumor-microenvironment
#16
Miao-Fen Chen, Ping-Tsung Chen, Ming-Shian Lu, Wen-Cheng Chen
Aldehyde dehydrogenase 1 (ALDH1) is associated with tumorigenesis, and significantly increased in cancer stem-like cells. In the present study, the role of ALDH1 in esophageal squamous cell carcinoma (ESCC) was investigated. We retrospectively analyzed the clinical outcomes of 148 ESCC and examined its correlation with ALDH1 levels. Furthermore, we preformed cellular and animal experiments to investigate the role of ALDH1 in tumor progression and microenvironment. Our data revealed that ALDH1 staining was positively linked to a higher clinical stage, higher loco-regional failure rate and shorter survival time...
September 9, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28887558/dramatically-enhanced-superconductivity-in-elemental-bismuth-from-excitonic-fluctuation-exchange
#17
S Koley, M S Laad, A Taraphder
Motivated by the remarkable discovery of superconductivity in elemental Bismuth at ambient pressure, we study its normal state in detail using a combination of tight-binding (TB) band-structure supplemented by dynamical mean-field theory (DMFT). We show that a two-fluid model composed of preformed and dynamically fluctuating excitons coupled to a tiny number of carriers provides a unified rationalization of a range of ill-understood normal state spectral and transport data. Based on these, we propose that resonant scattering involving a very low density of renormalized carriers and the excitonic liquid drives logarithmic enhancement of vertex corrections, boosting superconductivity in Bi...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887056/quantification-of-volume-and-lipid-filling-of-intracellular-vesicles-carrying-the-abca3-transporter
#18
Stefanie Höppner, Susanna Kinting, Adriano A Torrano, Ulrike Schindlbeck, Christoph Bräuchle, Ralf Zarbock, Thomas Wittman, Matthias Griese
The ABCA3 lipid transporter is located in the limiting membrane of lamellar bodies (LBs) in type-II-pneumocytes. Mutations within the ABCA3 gene may functionally impair the transporter, causing lung diseases in newborns, children and adults. Assays to quantify volume and lipid filling of the LBs on the level of the vesicular structures and thereby assess the function of ABCA3 are still lacking. In the present study human influenza haemagglutinin- (HA-) tagged wild type and mutant ABCA3 proteins were stably expressed in lung A549 cells...
September 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28882703/pegylation-for-enhancing-nanoparticle-diffusion-in-mucus
#19
Justin T Huckaby, Samuel K Lai
The viscoelastic mucus secretions coating exposed organs such as the lung airways and the female reproductive tract can trap and quickly eliminate not only foreign pathogens and ultrafine particles but also particle-based drug delivery systems, thus limiting sustained and targeted drug delivery at mucosal surfaces. To improve particle distribution across the mucosa and enhance delivery to the underlying epithelium, many investigators have sought to develop nanoparticles capable of readily traversing mucus. The first synthetic nanoparticles shown capable of rapidly penetrating physiological mucus secretions utilized a dense coating of polyethylene glycol (PEG) covalently grafted onto the surface of preformed polymeric nanoparticles...
September 4, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28882180/high-performance-of-targeted-next-generation-sequencing-on-variance-detection-in-clinical-tumor-specimens-in-comparison-with-current-conventional-methods
#20
Dan Su, Dadong Zhang, Kaiyan Chen, Jing Lu, Junzhou Wu, Xinkai Cao, Lisha Ying, Qihuang Jin, Yizhou Ye, Zhenghua Xie, Lei Xiong, Weimin Mao, Fugen Li
BACKGROUND: Next generation sequencing (NGS) is being increasingly applied for assisting cancer molecular diagnosis. However, it is still needed to validate NGS accuracy on detection of DNA alternations based on a large number of clinical samples, especially for DNA rearrangements and copy number variations (CNVs). This study is to set up basic parameters of targeted NGS for clinical diagnosis and to understand advantage of targeted NGS in comparison with the conventional methods of molecular diagnosis...
September 7, 2017: Journal of Experimental & Clinical Cancer Research: CR
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