keyword
MENU ▼
Read by QxMD icon Read
search

Preformance

keyword
https://www.readbyqxmd.com/read/28443279/analogs-of-the-frog-skin-antimicrobial-peptide-temporin-1tb-exhibit-a-wider-spectrum-of-activity-and-a-stronger-antibiofilm-potential-as-compared-to-the-parental-peptide
#1
Lucia Grassi, Giuseppantonio Maisetta, Giuseppe Maccari, Semih Esin, Giovanna Batoni
The frog skin-derived peptide Temporin 1Tb (TB) has gained increasing attention as novel antimicrobial agent for the treatment of antibiotic-resistant and/or biofilm-mediated infections. Nevertheless, such a peptide possesses a preferential spectrum of action against Gram-positive bacteria. In order to improve the therapeutic potential of TB, the present study evaluated the antibacterial and antibiofilm activities of two TB analogs against medically relevant bacterial species. Of the two analogs, TB_KKG6A has been previously described in the literature, while TB_L1FK is a new analog designed by us through statistical-based computational strategies...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28441965/evaluation-of-a-dna-a%C3%AE-42-vaccine-in-adult-rhesus-monkeys-macaca-mulatta-antibody-kinetics-and-immune-profile-after-intradermal-immunization-with-full-length-dna-a%C3%AE-42-trimer
#2
Doris Lambracht-Washington, Min Fu, Pat Frost, Roger N Rosenberg
BACKGROUND: Aggregated amyloid-β peptide 1-42 (Aβ42), derived from the cellular amyloid precursor protein, is one of the pathological hallmarks of Alzheimer's disease (AD). Although active immunization against Aβ42 peptide was successful in AD mouse models and led to removal of plaques and improved memory, a similar clinical trial in humans (Aβ42 peptide immunization with QS-21 adjuvant) was stopped in phase II, when 6% of the treated patients developed encephalitis. Currently ongoing passive immunizations with the injection of preformed monoclonal antibodies against different epitopes within the Aβ1-42 peptide, which do not lead to activation of the immune system, have shown some effects in slowing AD pathology...
April 26, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28441799/-treatment-of-bilateral-vocal-cord-paralysis-by-hemi-phrenic-nerve-transfer
#3
W Song, M Li, H L Zheng, L Sun, S C Chen, D H Chen, F Liu, M H Zhu, C Y Zhang, W Wang
Objective: To investigate the surgical effect of reinnervation of bilateral posterior cricoarytenoid muscles(PCA) with left hemi-phrenic nerve and endoscopic laser arytenoid resection in bilateral vocal cord fold paralysis(BVFP) and to analyze the pros and cons of the two methods. Methods: One hundred and seventeen BVFP patients who underwent reinnervation of bilateral PCA using the left hemi-phrenic nerve approach (nerve group, n=52) or laser arytenoidectomy(laser group, n=65) were enrolled in this study from Jan...
April 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28437746/catalytic-reduction-of-4-nitrophenol-and-photo-inhibition-of-pseudomonas-aeruginosa-using-gold-nanoparticles-as-photocatalyst
#4
Shafiullah Khan, Wang Runguo, Kamran Tahir, Zhang Jichuan, Liqun Zhang
A simple, green method is described for the synthesis of Gold (Au) nanoparticles (NPs) using Cotoneaster horizontalis extract as a phyto-reducer and capping agent with superior photo inhibition activity against Pseudomonas aeruginosa. Different from the other methods used elevated temperatures for nanoparticles synthesis, the novelty of our method lies in its energy saving process and fast synthesis rates (~5min for AuNPs), and its potential to tune the nanoparticles size and afterward their catalytic activity...
April 13, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28437684/fibrillar-disruption-by-ac-electric-field-induced-oscillation-a-case-study-with-human-serum-albumin
#5
Shubhatam Sen, Monojit Chakraborty, Snigdha Goley, Swagata Dasgupta, Sunando DasGupta
The effect of oscillation induced by a frequency-dependent alternating current (AC) electric field to dissociate preformed amyloid fibrils has been investigated. An electrowetting-on-dielectric type setup has been used to apply the AC field of varying frequencies on preformed fibrils of human serum albumin (HSA). The disintegration potency has been monitored by a combination of spectroscopic and microscopic techniques. The experimental results suggest that the frequency of the applied AC field plays a crucial role in the disruption of preformed HSA fibrils...
April 13, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28436306/cardiac-magnetic-resonance-imaging-has-limited-additional-yield-in-cryptogenic-stroke-evaluation-after-transesophageal-echocardiography
#6
Ava L Liberman, Rizwan E Kalani, Jessie Aw-Zoretic, Matthew Sondag, Vistasp J Daruwalla, Sumeet S Mitter, Richard Bernstein, Jeremy D Collins, Shyam Prabhakaran
Background The use of cardiac magnetic resonance imaging is increasing, but its role in the diagnostic work-up following ischemic stroke has received limited study. We aimed to explore the added yield of cardiac magnetic resonance imaging to identify cardio-aortic sources not detected by transesophageal echocardiography among patients with cryptogenic stroke. Methods A retrospective single-center cohort study was performed from 01 January 2009 to 01 March 2013. Consecutive patients who had both a stroke protocol cardiac magnetic resonance imaging and a transesophageal echocardiography preformed during a single hospitalization were included...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28436276/should-trained-lay-providers-perform-hiv-testing-a-systematic-review-to-inform-world-health-organization-guidelines
#7
C E Kennedy, P T Yeh, C Johnson, R Baggaley
New strategies for HIV testing services (HTS) are needed to achieve UN 90-90-90 targets, including diagnosis of 90% of people living with HIV. Task-sharing HTS to trained lay providers may alleviate health worker shortages and better reach target groups. We conducted a systematic review of studies evaluating HTS by lay providers using rapid diagnostic tests (RDTs). Peer-reviewed articles were included if they compared HTS using RDTs performed by trained lay providers to HTS by health professionals, or to no intervention...
April 24, 2017: AIDS Care
https://www.readbyqxmd.com/read/28434260/dapsone-associated-fixed-drug-eruption
#8
Daniel Garcia, Philip R Cohen
Dapsone is a sulfone drug used to treat infectious conditions and also numerous dermatologic diseases. Fixed drug eruption is a distinctive adverse cutaneous reaction associated with the initial administration and subsequent delivery of a specific agent. Areas Covered: The authors preformed a literature search using the following keywords: dapsone, fixed drug eruption, and adverse cutaneous drug reaction. Bibliographies were also reviewed for pertinent articles. The results were combed for relevant papers and reviewed...
April 24, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28426222/structural-and-dynamical-properties-of-tetra-alkyl-ammonium-bromide-aqueous-solutions-a-molecular-dynamics-simulation-study-using-a-polarizable-force-field
#9
Dengpan Dong, Justin B Hooper, Dmitry Bedrov
Understanding the behavior of aqueous solutions containing tetra-alkyl ammonium (TAA) cations is of great significance in a number of applications, including polymer membranes for fuel cells. In this work, a polarizable force field has been used to preform atomistic molecular dynamics (MD) simulations of aqueous solutions containing tetra-methyl ammonium (TMA) or tetra-butyl ammonium (TBA) cations and Br counterions. Extensive MD simulations of TMA-Br/water and TBA-Br/water systems were conducted as a function of solution composition (ion pair : water molar ratios of 1:10, 1:20, 1:30, 1:63, 1:500) at atmospheric pressure and 298K...
April 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28426152/donor-specific-alloreactive-t-cells-can-be-quantified-from-whole-blood-and-may-predict-cellular-rejection-after-renal-transplantation
#10
Michaela Fischer, Sarah Leyking, Marco Schäfer, Julia Elsäßer, Martin Janssen, Janine Mihm, Kai van Bentum, Danilo Fliser, Martina Sester, Urban Sester
Preformed cellular alloreactivity can exist prior to transplantation and may contribute to rejection. Here, we used a rapid flow-cytometric whole-blood assay to characterize the extent of alloreactive T cells among 1491 stimulatory reactions from 61 renal transplant candidates and 75 controls. The role of preformed donor-specific alloreactive T cells in cellular rejection was prospectively analyzed in 21 renal transplant recipients. Alloreactive CD8(+) T cells were more frequent than respective CD4(+) T cells, and these levels were stable over time...
April 20, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28422484/direct-synthesis-of-dextran-based-antibacterial-hydrogels-for-extended-release-of-biocides-and-eradication-of-topical-biofilms
#11
Jiaul Hoque, Jayanta Haldar
Cationic small molecular biocides have been developed as promising antibiofilm agents because of their tunability in chemical structures and ability to disrupt established biofilms. However, the impact of biocides in antibiofilm treatment is largely limited due to lack of an effective delivery system that can ensure sustained release of biocide at the target site. Herein we report biocide-encapsulated antibacterial and antibiofilm hydrogel that acts as efficient delivery vehicle for the biocide and eradicates matured bacterial biofilm...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28422057/antifungal-and-anti-biofilm-activities-of-acetone-lichen-extracts-against-candida-albicans
#12
Marion Millot, Marion Girardot, Lucile Dutreix, Lengo Mambu, Christine Imbert
Candida albicans is a commensal coloniser of the human gastrointestinal tract and an opportunistic pathogen, especially thanks to its capacity to form biofilms. This lifestyle is frequently involved in infections and increases the yeast resistance to antimicrobials and immune defenses. In this context, 38 lichen acetone extracts have been prepared and evaluated for their activity against C. albicans planktonic and sessile cells. Minimum inhibitory concentrations of extracts (MICs) were determined using the broth microdilution method...
April 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28421562/prevention-of-bacterial-biofilm-formation-on-soft-contact-lenses-using-natural-compounds
#13
Amira M El-Ganiny, Ghada H Shaker, Abeer A Aboelazm, Heba A El-Dash
PURPOSE: In eye care field, contact lenses (CL) have a great impact on improving vision, but their use can be limited by ocular infection. CL- associated infections can be reduced by good attention to CL storage case practice. CL-care solutions should be able to control microbial growth on CL. The aim of the study was to evaluate and compare the efficacy of CL-care solutions (found in Egyptian market) with some natural compounds in removal and inhibition of bacterial biofilm formed on soft CL...
December 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/28420216/fast-bragg-grating-inscription-in-pmma-polymer-optical-fibres-impact-of-thermal-pre-treatment-of-preforms
#14
Carlos A F Marques, Andreas Pospori, Gökhan Demirci, Onur Çetinkaya, Barbara Gawdzik, Paulo Antunes, Ole Bang, Pawel Mergo, Paulo André, David J Webb
In this work, fibre Bragg gratings (FBGs) were inscribed in two different undoped poly- (methyl methacrylate) (PMMA) polymer optical fibres (POFs) using different types of UV lasers and their inscription times, temperature and strain sensitivities are investigated. The POF Bragg gratings (POFBGs) were inscribed using two UV lasers: a continuous UV HeCd @325 nm laser and a pulsed UV KrF @248 nm laser. Two PMMA POFs are used in which the primary and secondary preforms (during the two-step drawing process) have a different thermal treatment...
April 18, 2017: Sensors
https://www.readbyqxmd.com/read/28417511/algal-supplementation-of-vegetarian-eating-patterns-improves-plasma-and-serum-docosahexaenoic-acid-concentrations-and-omega-3-indices-a-systematic-literature-review
#15
REVIEW
J C Craddock, E P Neale, Y C Probst, G E Peoples
BACKGROUND: Vegetarians are likely to have lower intakes of preformed docosahexaenoic acid (DHA) than omnivorous populations who consume fish and animal products. As such, vegetarian populations have omega-3 indices up to 60% lower than those who consume marine products. Algae, the primary producer of DHA in the marine food chain, offer an alternative source of DHA for those who do not consume marine or animal products. This systematic review aims to examine the evidence for the relationship between supplementation with algal forms of DHA and increased DHA concentrations in vegetarian populations...
April 17, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28414450/fabrication-of-au-nanoparticle-embedded-lipid-bilayer-membranes-supported-on-solid-substrates
#16
Naotoshi Sakaguchi, Yasuo Kimura, Ayumi Hirano-Iwata, Toshio Ogino
We fabricated gold nanoparticle (Au-NP)-embedded supported lipid bilayers (SLBs) by two methods. In the vesicle-vesicle fusion method, vesicles with hydrophobized Au-NPs are ruptured and fused on SiO2/Si substrates. In the vesicle-membrane fusion method, SLBs without Au-NPs were preformed on the substrate and then vesicles with Au-NPs were fused into the preformed membranes. In the former method, Au-NP incorporation into the SLBs was observed as an increase in the membrane thickness in atomic force microscopy (AFM) images and directly observed by transmission electron microscopy...
April 24, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28414290/-the-effect-of-isatin-on-protein-protein-interactions-between-cytochrome-b5-and-cytochromes-p450
#17
P V Ershov, E O Yablokov, Yu V Mezentsev, L A Kalushskiy, A V Florinskaya, A V Veselovsky, O V Gnedenko, A A Gilep, S A Usanov, A E Medvedev, A S Ivanov
Cytochromes P450 (CYP) are involved in numerous biochemical processes including metabolism of xenobiotics, biosynthesis of cholesterol, steroid hormones etc. Since some CYP catalyze indol oxidation to isatin, we have hypothesized that isatin can regulate protein-protein interactions (PPI) between components of the CYP system thus representing a (negative?) feedback mechanism. The aim of this study was to investigate a possible effect of isatin on interaction of human CYP with cytochrome b5 (CYB5A). Using the optical biosensor test system employing surface plasmon resonance (SPR) we have investigated interaction of immobilized CYB5A with various CYP in the absence and in the presence of isatin...
March 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/28412155/ascorbic-acid-inhibits-human-insulin-aggregation-and-protects-against-amyloid-induced-cytotoxicity
#18
Parvez Alam, Ayesha Zainab Beg, Mohammad Khursheed Siddiqi, Sumit Kumar Chaturvedi, Ravi Kant Rajpoot, Mohd Rehan Ajmal, Masihuz Zaman, Ali S Abdelhameed, Rizwan Hasan Khan
Protein aggregation into oligomers and fibrils are associated with many human pathophysiologies. Compounds that modulate protein aggregation and interact with preformed fibrils and convert them to less toxic species, expect to serve as promising drug candidates and aid to the drug development efforts against aggregation diseases. In present study, the kinetics of amyloid fibril formation by human insulin (HI) and the anti-amyloidogenic activity of ascorbic acid (AA) were investigated by employing various spectroscopic, imaging and computational approaches...
May 1, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28411638/approaches-for-conjugating-tailor-made-polymers-to-proteins
#19
Matthew Paeth, Jacob Stapleton, Melissa L Dougherty, Henry Fischesser, Jerry Shepherd, Matthew McCauley, Rebecca Falatach, Richard C Page, Jason A Berberich, Dominik Konkolewicz
A series of methods are outlined for attaching functional polymers to proteins. Polymers with good control over structure, functionality, and composition can be created using reversible addition-fragmentation chain transfer (RAFT) polymerization. These polymers can be covalently linked to enzymes and proteins using either the "grafting-to" approach, where a preformed polymer is attached to the protein surface, or the "grafting-from" approach, where the polymer is grown from the protein surface. Methods for grafting-to, or attaching the RAFT chain transfer agent to the protein surface outlined include the commonly used carbodiimide/activated ester (EDC/NHS) coupling...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28410976/genome-editing-via-delivery-of-cas9-ribonucleoprotein
#20
Mark DeWitt, Jacob E Corn, Dana Carroll
The CRISPR-Cas genome editing system is very powerful. The format of the CRISPR reagents and the means of delivery are often important factors in targeting efficiency. Delivery of recombinant Cas9 protein and guide RNA (gRNA) as a preformed ribonucleoprotein (RNP) complex has recently emerged as a powerful and general approach to genome editing. Here we outline methods to produce and deliver Cas9 RNPs. A donor DNA carrying desired sequence changes can also be included to program precise sequence introduction or replacement...
April 11, 2017: Methods: a Companion to Methods in Enzymology
keyword
keyword
45413
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"