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https://www.readbyqxmd.com/read/28583705/associations-of-newborn-brain-magnetic-resonance-imaging-with-long-term-neurodevelopmental-impairments-in-very-preterm-children
#1
Peter J Anderson, Karli Treyvaud, Jeffrey J Neil, Jeanie L Y Cheong, Rodney W Hunt, Deanne K Thompson, Katherine J Lee, Lex W Doyle, Terrie E Inder
OBJECTIVE: To determine the relationship between brain abnormalities on newborn magnetic resonance imaging (MRI) and neurodevelopmental impairment at 7 years of age in very preterm children. STUDY DESIGN: A total of 223 very preterm infants (<30 weeks of gestation or <1250 g) born at Melbourne's Royal Women's Hospital had a brain MRI scan at term equivalent age. Scans were scored using a standardized system that assessed structural abnormality of cerebral white matter, cortical gray matter, deep gray matter, and cerebellum...
June 2, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28476422/long-term-results-of-anatomic-correction-for-congenitally-corrected-transposition-of-the-great-arteries-a-19-year-experience
#2
Christian P Brizard, Alice Lee, Diana Zannino, Andrew M Davis, Tyson A Fricke, Yves d'Udekem, Igor E Konstantinov, Johann Brink, Michael M H Cheung
OBJECTIVE: The surgical indication, timing, strategy, and surgical technique for anatomic correction of congenitally corrected transposition of the great arteries are challenging. We evaluated the long-term results at The Royal Children's Hospital Melbourne. METHODS: Review of 32 successive anatomic corrections between 1996 and 2015. RESULTS: Twenty-one double-switch (66%), 6 Senning/Bex-Nikaidoh (19%), and 5 Senning/Rastelli (16%) procedures were performed (median age, 1...
July 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28349556/cerebral-oxygenation-as-measured-by-near-infrared-spectroscopy-in-neonatal-intensive-care-correlation-with-arterial-oxygenation
#3
Carol Lu Hunter, Ju Lee Oei, Kei Lui, Timothy Schindler
AIM: To assess correlation between cerebral oxygenation (rScO2 ), as measured by near-infrared spectroscopy (NIRS), and arterial oxygenation (PaO2 ), as measured by arterial blood gases, in preterm neonates. METHODS: Preterm neonates <37 weeks gestation with an indwelling arterial vascular catheter were recruited between April and August 2015 from the neonatal intensive care unit of the Royal Hospital for Women, Randwick NSW, Australia. The NIRS sensor was placed on the frontolateral aspect of the head prior to arterial gas sampling...
March 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28260265/managing-corneal-foreign-bodies-in-office-based-general-practice
#4
Alison Fraenkel, Lawrence R Lee, Graham A Lee
BACKGROUND: Patients with a corneal foreign body may first present to their general practitioner (GP). Safe and efficacious management of these presentations avoids sight-threatening and eye-threatening complications. Removal of a simple, superficial foreign body without a slit lamp is within The Royal Australian College of General Practitioners' (RACGP's) curriculum and scope of practice. Knowing the rele-vant procedural skills and indications for referral is equally important. OBJECTIVE: The objective of this article is to provide an evidence-based and expert-based guide to the management of corneal foreign bodies in the GP's office...
March 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28218755/changes-in-the-incidence-patterns-and-outcomes-of-graft-failure-following-hematopoietic-stem-cell-transplantation-for-hurler-syndrome
#5
S H Lum, W P Miller, S Jones, K Poulton, W Ogden, H Lee, A Logan, D Bonney, T C Lund, P J Orchard, R F Wynn
Hematopoietic stem cell transplantation (HSCT) is the standard of care in children with Hurler syndrome (HS) as it is the only therapy that can arrest disease progression. We examined the incidence, patterns and outcomes of graft failure in all HS children undergoing first HSCT at the Royal Manchester Children's Hospital or the University of Minnesota Children's Hospital from 1983 to 2016. Implementation of busulfan pharmacokinetic monitoring started in 2004 in both institutions. Two hundred and forty HS children were included in this analysis (historical era (pre-2004), n=131; current era (post 2004), n=109)...
June 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28188769/lifetime-cancer-risk-and-combined-oral-contraceptives-the%C3%A2-royal-college-of-general-practitioners-oral-contraception-study
#6
Lisa Iversen, Selvaraj Sivasubramaniam, Amanda J Lee, Shona Fielding, Philip C Hannaford
BACKGROUND: Oral contraceptives have been used by hundreds of millions of women around the world. Important questions remain regarding the very long-term cancer risks that are associated with oral contraception. Despite previous research, important questions remain about the safety of these contraceptives: (1) How long do endometrial, ovarian, and colorectal cancer benefits persist? (2) Does combined oral contraceptive use during the reproductive years produce new cancer risks later in life? (3) What is the overall balance of cancer among past users as they enter the later stages of their lives? OBJECTIVES: The purpose of this study was to examine the very long-term cancer risks or benefits associated with the use of combined oral contraceptives, including the estimated overall life-time balance...
February 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28152144/association-between-moderate-and-late-preterm-birth-and-neurodevelopment-and-social-emotional-development-at-age-2-years
#7
Jeanie L Cheong, Lex W Doyle, Alice C Burnett, Katherine J Lee, Jennifer M Walsh, Cody R Potter, Karli Treyvaud, Deanne K Thompson, Joy E Olsen, Peter J Anderson, Alicia J Spittle
Importance: Moderate and late preterm (MLPT) births comprise most preterm infants. Therefore, long-term developmental concerns in this population potentially have a large public health influence. While there are increasing reports of developmental problems in MLPT children, detail is lacking on the precise domains that are affected. Objective: To compare neurodevelopment and social-emotional development between MLPT infants and term-born control infants at age 2 years...
April 3, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28131800/changing-objective-structured-clinical-examinations-stations-at-lunchtime-during-all-day-postgraduate-surgery-examinations-improves-examiner-morale-and-stress
#8
Peter A Brennan, Duncan S Scrimgeour, Sheena Patel, Roshnee Patel, Gareth Griffiths, David T Croke, Lee Smith, Richard Arnett
BACKGROUND: Human factors are important causes of error, but little is known about their possible effect during objective structured clinical examinations (OSCE). We have previously identified stress and pressure in OSCE examiners in the postgraduate intercollegiate Membership of the Royal College of Surgeons (MRCS) examination. After modifying examination delivery by changing OSCE stations at lunchtime with no demonstrable effect on candidate outcome, we resurveyed examiners to ascertain whether examiner experience was improved...
January 26, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28118692/intercollegiate-conversations-australian-and-new-zealand-college-of-anaesthetists
#9
Victor Lee, Ian S Graham
In the first of a series of online interviews with other Australian and New Zealand Specialty Colleges about the developments and shared challenges with implementing competency-based medical education, I spoke with the current Dean of Education at the Australian and New Zealand College of Anaesthetists, Dr Ian Graham. Dr Graham is not an anaesthetist. He is a Fellow of the Royal Australasian College of Medical Administrators, educator and consultant in health management. He was appointed into the role of part-time Dean of Education at the Australian and New Zealand College of Anaesthetists in August 2014...
June 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28093552/integrating-hebbian-and-homeostatic-plasticity-the-current-state-of-the-field-and-future-research-directions
#10
REVIEW
Tara Keck, Taro Toyoizumi, Lu Chen, Brent Doiron, Daniel E Feldman, Kevin Fox, Wulfram Gerstner, Philip G Haydon, Mark Hübener, Hey-Kyoung Lee, John E Lisman, Tobias Rose, Frank Sengpiel, David Stellwagen, Michael P Stryker, Gina G Turrigiano, Mark C van Rossum
We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next provide a synopsis of the outstanding questions that emerged from the discussion at the end of the meeting and finally suggest potential directions of research that we believe are most promising to develop an understanding of how these two forms of plasticity interact to facilitate functional changes in the brain...
March 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27965823/feasibility-of-a-stepped-wedge-cluster-rct-and-concurrent-observational-sub-study-to-evaluate-the-effects-of-modified-ward-night-lighting-on-inpatient-fall-rates-and-sleep-quality-a-protocol-for-a-pilot-trial
#11
Satyan R Chari, Simon Smith, Alison Mudge, Alex A Black, Mariana Figueiro, Muhtashimuddin Ahmed, Mark Devitt, Terry P Haines
BACKGROUND: Falls among hospitalised patients impose a considerable burden on health systems globally and prevention is a priority. Some patient-level interventions have been effective in reducing falls, but others have not. An alternative and promising approach to reducing inpatient falls is through the modification of the hospital physical environment and the night lighting of hospital wards is a leading candidate for investigation. In this pilot trial, we will determine the feasibility of conducting a main trial to evaluate the effects of modified night lighting on inpatient ward level fall rates...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27917481/comprehensive-cellular-resolution-atlas-of-the-adult-human-brain
#12
Song-Lin Ding, Joshua J Royall, Susan M Sunkin, Lydia Ng, Benjamin A C Facer, Phil Lesnar, Angie Guillozet-Bongaarts, Bergen McMurray, Aaron Szafer, Tim A Dolbeare, Allison Stevens, Lee Tirrell, Thomas Benner, Shiella Caldejon, Rachel A Dalley, Nick Dee, Christopher Lau, Julie Nyhus, Melissa Reding, Zackery L Riley, David Sandman, Elaine Shen, Andre van der Kouwe, Ani Varjabedian, Michelle Write, Lilla Zollei, Chinh Dang, James A Knowles, Christof Koch, John W Phillips, Nenad Sestan, Paul Wohnoutka, H Ronald Zielke, John G Hohmann, Allan R Jones, Amy Bernard, Michael J Hawrylycz, Patrick R Hof, Bruce Fischl, Ed S LeinReference
No abstract text is available yet for this article.
February 1, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27875925/the-application-of-subjective-job-task-analysis-techniques-in-physically-demanding-occupations-evidence-for-the-presence-of-self-serving-bias
#13
Benjamin Lee-Bates, Daniel C Billing, Peter Caputi, Greg L Carstairs, Denise Linnane, Kane Middleton
The aim of this study was to determine if perceptions of physically demanding job tasks are biased by employee demographics and employment profile characteristics including: age, sex, experience, length of tenure, rank and if they completed or supervised a task. Surveys were administered to 427 Royal Australian Navy personnel who characterised 33 tasks in terms of physical effort, importance, frequency, duration and vertical/horizontal distance travelled. Results showed no evidence of bias resulting from participant characteristics, however participants who were actively involved in both task participation and supervision rated these tasks as more important than those involved only in the supervision of that task...
December 9, 2016: Ergonomics
https://www.readbyqxmd.com/read/27703793/gadl1-variant-and-medication-adherence-in-predicting-response-to-lithium-maintenance-treatment-in-bipolar-i-disorder
#14
Chih-Ken Chen, Chau-Shoun Lee, Hsuan-Yu Chen, Lawrence Shih-Hsin Wu, Jung-Chen Chang, Chia-Yih Liu, Andrew Tai-Ann Cheng
BACKGROUND: Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders. AIMS: To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder. METHOD: Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n=215)...
September 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703779/-he-left-me-a-message-on-facebook-comparing-the-risk-profiles-of-self-harming-patients-who-leave-paper-suicide-notes-with-those-who-leave-messages-on-new-media
#15
Jessica R Barrett, Hitesh Shetty, Matthew Broadbent, Sean Cross, Matthew Hotopf, Robert Stewart, William Lee
BACKGROUND: In cases of non-fatal self-harm, suicide notes are a major risk factor for repeated self-harm and suicide. Suicide notes can now be left on new media services, emails or text messages, as well as on paper. AIMS: In a group of people who had harmed themselves, we aimed to compare new media note-leavers with paper note-leavers and characterise these groups demographically and by risk factors. METHOD: Clinical notes of patients who presented with non-fatal self-harm to two London emergency departments were anonymously searched for mentions of new media use...
May 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703772/the-people-with-asperger-syndrome-and-anxiety-disorders-passa-trial-a-pilot-multicentre-single-blind-randomised-trial-of-group-cognitive-behavioural-therapy
#16
Peter E Langdon, Glynis H Murphy, Lee Shepstone, Edward C F Wilson, David Fowler, David Heavens, Aida Malovic, Alexandra Russell, Alice Rose, Louise Mullineaux
BACKGROUND: There is a growing interest in using cognitive-behavioural therapy (CBT) with people who have Asperger syndrome and comorbid mental health problems. AIMS: To examine whether modified group CBT for clinically significant anxiety in an Asperger syndrome population is feasible and likely to be efficacious. METHOD: Using a randomised assessor-blind trial, 52 individuals with Asperger syndrome were randomised into a treatment arm or a waiting-list control arm...
March 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703770/maternal-vitamin-d-deficiency-and-the-risk-of-autism-spectrum-disorders-population-based-study
#17
Cecilia Magnusson, Michael Lundberg, Brian K Lee, Dheeraj Rai, Håkan Karlsson, Renee Gardner, Kyriaki Kosidou, Stefan Arver, Christina Dalman
BACKGROUND: Maternal vitamin D deficiency may increase risk of autism spectrum disorder (ASD), but direct evidence is lacking. AIMS: To clarify the relationship between maternal vitamin D deficiency and offspring risk of ASD with and without intellectual disability. METHOD: Using a register-based total population study (N=509 639), we calculated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of ASD with and without intellectual disability in relation to lifetime diagnoses of maternal vitamin D deficiency...
March 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703760/predicting-hospital-aggression-in-secure-psychiatric-care
#18
Jane L Ireland, Lee J Priday, Carol A Ireland, Simon Chu, Jennifer Kilcoyne, Caroline Mulligan
BACKGROUND: Risk assessment instruments have become a preferred means for predicting future aggression, claiming to predict long-term aggression risk. AIMS: To investigate the predictive value over 12 months and 4 years of two commonly applied instruments (Historical, Clinical and Risk Management - 20 (HCR-20) and Violence Risk Appraisal Guide (VRAG)). METHOD: Participants were adult male psychiatric patients detained in a high secure hospital...
January 2016: BJPsych Open
https://www.readbyqxmd.com/read/27634166/motor-trajectories-from-birth-to-5-years-of-children-born-at-less-than-30-weeks-gestation-early-predictors-and-functional-implications-protocol-for-a-prospective-cohort-study
#19
Alicia J Spittle, Jennifer L McGinley, Deanne Thompson, Ross Clark, Tara L FitzGerald, Benjamin F Mentiplay, Katherine J Lee, Joy E Olsen, Alice Burnett, Karli Treyvaud, Elisha Josev, Bonnie Alexander, Claire E Kelly, Lex W Doyle, Peter J Anderson, Jeanie Ly Cheong
INTRODUCTION: Motor impairments are one of the most frequently reported adverse neurodevelopmental consequences in children born < 30 weeks' gestation. Up to 15% of children born at < 30 weeks have cerebral palsy and an additional 50% have mild to severe motor impairment at school age. The first 5 years of life are critical for the development of fundamental motor skills. These skills form the basis for more complex skills that are required to competently and confidently participate in schooling, sporting and recreational activities...
October 2016: Journal of Physiotherapy
https://www.readbyqxmd.com/read/27609629/clabsi-risk-factors-in-the-nicu-potential-for-prevention-a-picnic-study
#20
Maya Dahan, Shauna O'Donnell, Julie Hebert, Milagros Gonzales, Bonita Lee, A Uma Chandran, Samantha Woolsey, Sandra Escoredo, Heather Chinnery, Caroline Quach
OBJECTIVE Central-line-associated bloodstream infections (CLABSI) are an important cause of morbidity and mortality in neonates. We aimed to determine whether intra-abdominal pathologies are an independent risk factor for CLABSI. METHODS We performed a retrospective matched case-control study of infants admitted to the neonatal intensive care units (NICUs) of the Montreal Children's Hospital (Montreal) and the Royal Alexandra Hospital, Edmonton, Canada. CLABSI cases that occurred between April 2009 and March 2014 were identified through local infection control databases...
December 2016: Infection Control and Hospital Epidemiology
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