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https://www.readbyqxmd.com/read/28093552/integrating-hebbian-and-homeostatic-plasticity-the-current-state-of-the-field-and-future-research-directions
#1
REVIEW
Tara Keck, Taro Toyoizumi, Lu Chen, Brent Doiron, Daniel E Feldman, Kevin Fox, Wulfram Gerstner, Philip G Haydon, Mark Hübener, Hey-Kyoung Lee, John E Lisman, Tobias Rose, Frank Sengpiel, David Stellwagen, Michael P Stryker, Gina G Turrigiano, Mark C van Rossum
We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next provide a synopsis of the outstanding questions that emerged from the discussion at the end of the meeting and finally suggest potential directions of research that we believe are most promising to develop an understanding of how these two forms of plasticity interact to facilitate functional changes in the brain...
March 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27965823/feasibility-of-a-stepped-wedge-cluster-rct-and-concurrent-observational-sub-study-to-evaluate-the-effects-of-modified-ward-night-lighting-on-inpatient-fall-rates-and-sleep-quality-a-protocol-for-a-pilot-trial
#2
Satyan R Chari, Simon Smith, Alison Mudge, Alex A Black, Mariana Figueiro, Muhtashimuddin Ahmed, Mark Devitt, Terry P Haines
BACKGROUND: Falls among hospitalised patients impose a considerable burden on health systems globally and prevention is a priority. Some patient-level interventions have been effective in reducing falls, but others have not. An alternative and promising approach to reducing inpatient falls is through the modification of the hospital physical environment and the night lighting of hospital wards is a leading candidate for investigation. In this pilot trial, we will determine the feasibility of conducting a main trial to evaluate the effects of modified night lighting on inpatient ward level fall rates...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27917481/comprehensive-cellular-resolution-atlas-of-the-adult-human-brain
#3
Song-Lin Ding, Joshua J Royall, Susan M Sunkin, Lydia Ng, Benjamin A C Facer, Phil Lesnar, Angie Guillozet-Bongaarts, Bergen McMurray, Aaron Szafer, Tim A Dolbeare, Allison Stevens, Lee Tirrell, Thomas Benner, Shiella Caldejon, Rachel A Dalley, Nick Dee, Christopher Lau, Julie Nyhus, Melissa Reding, Zackery L Riley, David Sandman, Elaine Shen, Andre van der Kouwe, Ani Varjabedian, Michelle Write, Lilla Zollei, Chinh Dang, James A Knowles, Christof Koch, John W Phillips, Nenad Sestan, Paul Wohnoutka, H Ronald Zielke, John G Hohmann, Allan R Jones, Amy Bernard, Michael J Hawrylycz, Patrick R Hof, Bruce Fischl, Ed S LeinReference
No abstract text is available yet for this article.
February 1, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27875925/the-application-of-subjective-job-task-analysis-techniques-in-physically-demanding-occupations-evidence-for-the-presence-of-self-serving-bias
#4
Benjamin Lee-Bates, Daniel C Billing, Peter Caputi, Greg L Carstairs, Denise Linnane, Kane Middleton
The aim of this study was to determine if perceptions of physically demanding job tasks are biased by employee demographics and employment profile characteristics including: age, sex, experience, length of tenure, rank and if they completed or supervised a task. Surveys were administered to 427 Royal Australian Navy personnel who characterised 33 tasks in terms of physical effort, importance, frequency, duration and vertical/horizontal distance travelled. Results showed no evidence of bias resulting from participant characteristics, however participants who were actively involved in both task participation and supervision rated these tasks as more important than those involved only in the supervision of that task...
December 9, 2016: Ergonomics
https://www.readbyqxmd.com/read/27703793/gadl1-variant-and-medication-adherence-in-predicting-response-to-lithium-maintenance-treatment-in-bipolar-i-disorder
#5
Chih-Ken Chen, Chau-Shoun Lee, Hsuan-Yu Chen, Lawrence Shih-Hsin Wu, Jung-Chen Chang, Chia-Yih Liu, Andrew Tai-Ann Cheng
BACKGROUND: Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders. AIMS: To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 (GADL1) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder. METHOD: Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder (n=215)...
September 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703779/-he-left-me-a-message-on-facebook-comparing-the-risk-profiles-of-self-harming-patients-who-leave-paper-suicide-notes-with-those-who-leave-messages-on-new-media
#6
Jessica R Barrett, Hitesh Shetty, Matthew Broadbent, Sean Cross, Matthew Hotopf, Robert Stewart, William Lee
BACKGROUND: In cases of non-fatal self-harm, suicide notes are a major risk factor for repeated self-harm and suicide. Suicide notes can now be left on new media services, emails or text messages, as well as on paper. AIMS: In a group of people who had harmed themselves, we aimed to compare new media note-leavers with paper note-leavers and characterise these groups demographically and by risk factors. METHOD: Clinical notes of patients who presented with non-fatal self-harm to two London emergency departments were anonymously searched for mentions of new media use...
May 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703772/the-people-with-asperger-syndrome-and-anxiety-disorders-passa-trial-a-pilot-multicentre-single-blind-randomised-trial-of-group-cognitive-behavioural-therapy
#7
Peter E Langdon, Glynis H Murphy, Lee Shepstone, Edward C F Wilson, David Fowler, David Heavens, Aida Malovic, Alexandra Russell, Alice Rose, Louise Mullineaux
BACKGROUND: There is a growing interest in using cognitive-behavioural therapy (CBT) with people who have Asperger syndrome and comorbid mental health problems. AIMS: To examine whether modified group CBT for clinically significant anxiety in an Asperger syndrome population is feasible and likely to be efficacious. METHOD: Using a randomised assessor-blind trial, 52 individuals with Asperger syndrome were randomised into a treatment arm or a waiting-list control arm...
March 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703770/maternal-vitamin-d-deficiency-and-the-risk-of-autism-spectrum-disorders-population-based-study
#8
Cecilia Magnusson, Michael Lundberg, Brian K Lee, Dheeraj Rai, Håkan Karlsson, Renee Gardner, Kyriaki Kosidou, Stefan Arver, Christina Dalman
BACKGROUND: Maternal vitamin D deficiency may increase risk of autism spectrum disorder (ASD), but direct evidence is lacking. AIMS: To clarify the relationship between maternal vitamin D deficiency and offspring risk of ASD with and without intellectual disability. METHOD: Using a register-based total population study (N=509 639), we calculated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of ASD with and without intellectual disability in relation to lifetime diagnoses of maternal vitamin D deficiency...
March 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703760/predicting-hospital-aggression-in-secure-psychiatric-care
#9
Jane L Ireland, Lee J Priday, Carol A Ireland, Simon Chu, Jennifer Kilcoyne, Caroline Mulligan
BACKGROUND: Risk assessment instruments have become a preferred means for predicting future aggression, claiming to predict long-term aggression risk. AIMS: To investigate the predictive value over 12 months and 4 years of two commonly applied instruments (Historical, Clinical and Risk Management - 20 (HCR-20) and Violence Risk Appraisal Guide (VRAG)). METHOD: Participants were adult male psychiatric patients detained in a high secure hospital...
January 2016: BJPsych Open
https://www.readbyqxmd.com/read/27634166/motor-trajectories-from-birth-to-5-years-of-children-born-at-less-than-30-weeks-gestation-early-predictors-and-functional-implications-protocol-for-a-prospective-cohort-study
#10
Alicia J Spittle, Jennifer L McGinley, Deanne Thompson, Ross Clark, Tara L FitzGerald, Benjamin F Mentiplay, Katherine J Lee, Joy E Olsen, Alice Burnett, Karli Treyvaud, Elisha Josev, Bonnie Alexander, Claire E Kelly, Lex W Doyle, Peter J Anderson, Jeanie Ly Cheong
INTRODUCTION: Motor impairments are one of the most frequently reported adverse neurodevelopmental consequences in children born < 30 weeks' gestation. Up to 15% of children born at < 30 weeks have cerebral palsy and an additional 50% have mild to severe motor impairment at school age. The first 5 years of life are critical for the development of fundamental motor skills. These skills form the basis for more complex skills that are required to competently and confidently participate in schooling, sporting and recreational activities...
October 2016: Journal of Physiotherapy
https://www.readbyqxmd.com/read/27609629/clabsi-risk-factors-in-the-nicu-potential-for-prevention-a-picnic-study
#11
Maya Dahan, Shauna O'Donnell, Julie Hebert, Milagros Gonzales, Bonita Lee, A Uma Chandran, Samantha Woolsey, Sandra Escoredo, Heather Chinnery, Caroline Quach
OBJECTIVE Central-line-associated bloodstream infections (CLABSI) are an important cause of morbidity and mortality in neonates. We aimed to determine whether intra-abdominal pathologies are an independent risk factor for CLABSI. METHODS We performed a retrospective matched case-control study of infants admitted to the neonatal intensive care units (NICUs) of the Montreal Children's Hospital (Montreal) and the Royal Alexandra Hospital, Edmonton, Canada. CLABSI cases that occurred between April 2009 and March 2014 were identified through local infection control databases...
December 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27511915/royal-london-space-analysis-plaster-versus-digital-model-assessment
#12
Balpreet Grewal, Robert T Lee, Lifong Zou, Ama Johal
AIM: With the advent of digital study models, the importance of being able to evaluate space requirements becomes valuable to treatment planning and the justification for any required extraction pattern. This study was undertaken to compare the validity and reliability of the Royal London space analysis (RLSA) undertaken on plaster as compared with digital models. MATERIALS AND METHODS: A pilot study (n = 5) was undertaken on plaster and digital models to evaluate the feasibility of digital space planning...
August 10, 2016: European Journal of Orthodontics
https://www.readbyqxmd.com/read/27428766/evolution-of-depression-and-anxiety-symptoms-in-parents-of-very-preterm-infants-during-the-newborn-period
#13
Carmen C Pace, Alicia J Spittle, Charlotte M-L Molesworth, Katherine J Lee, Elisabeth A Northam, Jeanie L Y Cheong, Peter G Davis, Lex W Doyle, Karli Treyvaud, Peter J Anderson
IMPORTANCE: Mothers experience heightened depression and anxiety following very preterm (VPT) birth, but how these symptoms evolve during the first months after birth is unknown. Research on the psychological adjustment of fathers following VPT birth is limited. OBJECTIVES: To describe the trajectory and predictors of distress in parents of VPT infants during the first 12 weeks after birth, and to compare rates of depression and anxiety in parents of VPT infants with those in parents of healthy full-term (FT) infants shortly after birth and at 6 months' postnatal age...
September 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27418273/comprehensive-cellular-resolution-atlas-of-the-adult-human-brain
#14
Song-Lin Ding, Joshua J Royall, Susan M Sunkin, Lydia Ng, Benjamin A C Facer, Phil Lesnar, Angie Guillozet-Bongaarts, Bergen McMurray, Aaron Szafer, Tim A Dolbeare, Allison Stevens, Lee Tirrell, Thomas Benner, Shiella Caldejon, Rachel A Dalley, Nick Dee, Christopher Lau, Julie Nyhus, Melissa Reding, Zackery L Riley, David Sandman, Elaine Shen, Andre van der Kouwe, Ani Varjabedian, Michelle Write, Lilla Zollei, Chinh Dang, James A Knowles, Christof Koch, John W Phillips, Nenad Sestan, Paul Wohnoutka, H Ronald Zielke, John G Hohmann, Allan R Jones, Amy Bernard, Michael J Hawrylycz, Patrick R Hof, Bruce Fischl, Ed S Lein
Detailed anatomical understanding of the human brain is essential for unraveling its functional architecture, yet current reference atlases have major limitations such as lack of whole-brain coverage, relatively low image resolution, and sparse structural annotation. We present the first digital human brain atlas to incorporate neuroimaging, high-resolution histology, and chemoarchitecture across a complete adult female brain, consisting of magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and 1,356 large-format cellular resolution (1 µm/pixel) Nissl and immunohistochemistry anatomical plates...
November 1, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27409810/a-comprehensive-transcriptional-map-of-primate-brain-development
#15
Trygve E Bakken, Jeremy A Miller, Song-Lin Ding, Susan M Sunkin, Kimberly A Smith, Lydia Ng, Aaron Szafer, Rachel A Dalley, Joshua J Royall, Tracy Lemon, Sheila Shapouri, Kaylynn Aiona, James Arnold, Jeffrey L Bennett, Darren Bertagnolli, Kristopher Bickley, Andrew Boe, Krissy Brouner, Stephanie Butler, Emi Byrnes, Shiella Caldejon, Anita Carey, Shelby Cate, Mike Chapin, Jefferey Chen, Nick Dee, Tsega Desta, Tim A Dolbeare, Nadia Dotson, Amanda Ebbert, Erich Fulfs, Garrett Gee, Terri L Gilbert, Jeff Goldy, Lindsey Gourley, Ben Gregor, Guangyu Gu, Jon Hall, Zeb Haradon, David R Haynor, Nika Hejazinia, Anna Hoerder-Suabedissen, Robert Howard, Jay Jochim, Marty Kinnunen, Ali Kriedberg, Chihchau L Kuan, Christopher Lau, Chang-Kyu Lee, Felix Lee, Lon Luong, Naveed Mastan, Ryan May, Jose Melchor, Nerick Mosqueda, Erika Mott, Kiet Ngo, Julie Nyhus, Aaron Oldre, Eric Olson, Jody Parente, Patrick D Parker, Sheana Parry, Julie Pendergraft, Lydia Potekhina, Melissa Reding, Zackery L Riley, Tyson Roberts, Brandon Rogers, Kate Roll, David Rosen, David Sandman, Melaine Sarreal, Nadiya Shapovalova, Shu Shi, Nathan Sjoquist, Andy J Sodt, Robbie Townsend, Lissette Velasquez, Udi Wagley, Wayne B Wakeman, Cassandra White, Crissa Bennett, Jennifer Wu, Rob Young, Brian L Youngstrom, Paul Wohnoutka, Richard A Gibbs, Jeffrey Rogers, John G Hohmann, Michael J Hawrylycz, Robert F Hevner, Zoltán Molnár, John W Phillips, Chinh Dang, Allan R Jones, David G Amaral, Amy Bernard, Ed S Lein
The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons...
21, 2016: Nature
https://www.readbyqxmd.com/read/27352081/exposure-calls-to-u-s-poison-centers-involving-electronic-cigarettes-and-conventional-cigarettes-september-2010-december-2014
#16
Kevin Chatham-Stephens, Royal Law, Ethel Taylor, Stephanie Kieszak, Paul Melstrom, Rebecca Bunnell, Baoguang Wang, Hannah Day, Benjamin Apelberg, Lee Cantrell, Howell Foster, Joshua G Schier
INTRODUCTION: E-cigarette use is increasing, and the long-term impact on public health is unclear. We described the acute adverse health effects from e-cigarette exposures reported to U.S. poison centers. METHODS: We compared monthly counts and demographic, exposure, and health effects data of calls about e-cigarettes and conventional cigarettes made to poison centers from September 2010 through December 2014. RESULTS: Monthly e-cigarette calls increased from 1 in September 2010, peaked at 401 in April 2014, and declined to 295 in December 2014...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27301857/-louis-xiv-s-ginseng-shaping-of-knowledge-on-an-herbal-medicine-in-the-late-17th-and-the-early-18th-century-france
#17
Hye-Min Lee
This article aims to investigate the shaping of knowledge and discourse on ginseng, especially among physicians and botanists, since its introduction to France from the 17th century until the early 18th century. In France, knowledge on herbal medicine, including that of ginseng, was shaped under the influence of the modern state's policy and institution: mercantilism and the Académie royale des sciences. The knowledge of herbal medicine developed as an important part of the mercantilist policy supported systematically by the Académie...
April 2016: Ŭi Sahak
https://www.readbyqxmd.com/read/27261420/geographical-variation-in-the-management-of-urolithiasis-in-australia
#18
Minh A Tran, Ming Chak-Lee, Simon V Bariol
BACKGROUND: To examine any geographical variation in the management of urolithiasis amongst the Australian states and territories. METHODS: Retrospective study with data obtained from the Medicare Australia database, the Royal Australasian College of Surgeons and the Urological Society of Australia and New Zealand. RESULTS: Minimally invasive stone treatment with shock wave lithotripsy (SWL) and ureteroscopy (URS) accounted for the majority of stone treatments in Australia (98%)...
June 3, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27183289/incidence-and-risk-factors-of-retinopathy-of-prematurity-from-2-neonatal-intensive-care-units-in-a-hong-kong-chinese-population
#19
Gordon S K Yau, Jacky W Y Lee, Victor T Y Tam, Catherine C L Liu, Stan Yip, Edith Cheng, Benjamin C Y Chu, Can Y F Yuen
PURPOSE: To determine the incidence and risk factors of retinopathy of prematurity (ROP) in very low birth weight (VLBW) preterm Chinese infants. DESIGN: Retrospective review. METHODS: Medical records were reviewed for all neonates screened for ROP between January 2007 and December 2012 in Hong Kong. Screening was offered to VLBW (≤1500 g) and/or preterm (gestation, ≤32 weeks) neonates using the Royal College of Ophthalmologists ROP guideline and the International Classification of ROP by 3 pediatric ophthalmologists...
May 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27083457/chairman-s-opening-address-at-the-sir-william-wilde-bi-centenary-symposium
#20
C Lee
The opening address by Professor T Clive Lee at the William Wilde Bi-Centenary Symposium, hosted by the Royal Academy of Medicine in Ireland, History of Medicine Section on 6 May 2015.
May 2016: Irish Journal of Medical Science
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