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https://www.readbyqxmd.com/read/27882658/access-to-clinical-trials-for-adolescents-with-soft-tissue-sarcomas-enrollment-in-european-pediatric-soft-tissue-sarcoma-study-group-epssg-protocols
#1
Andrea Ferrari, Annalisa Trama, Angela De Paoli, Christophe Bergeron, Johannes H M Merks, Meriel Jenney, Daniel Orbach, Julia C Chisholm, Soledad Gallego, Heidi Glosli, Gian Luca De Salvo, Laura Botta, Gemma Gatta, Gianni Bisogno
BACKGROUND: Adolescents with cancer are enrolled in clinical trials at far lower rates than children. This report compares the number of adolescents (15-19-year-olds) and children (0-14-year-olds) enrolled in the protocols of the European pediatric Soft tissue sarcoma Study Group (EpSSG) with the number of cases expected to occur. METHODS: The observed-to-expected (O/E) ratio was detected in the EpSSG countries contributing most of the cases, that is, Italy, France, Spain, the Netherlands, United Kingdom, and Ireland...
November 24, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27815245/the-coprinopsis-cinerea-tup1-homologue-cag1-is-required-for-gill-formation-during-fruiting-body-morphogenesis
#2
Ryo Masuda, Naoki Iguchi, Kooki Tukuta, Takahiro Nagoshi, Kazuki Kemuriyama, Hajime Muraguchi
The pileus (cap) of the fruiting body in homobasidiomycete fungi bears the hymenium, a layer of cells that includes the basidia where nuclear fusion, meiosis and sporulation occur. Coprinopsis cinerea is a model system for studying fruiting body development. The hymenium of C. cinerea forms at the surface of the gills in the pileus. In the previous study, we identified a mutation that blocks gill formation, which yields primordia that never mature called cap-growthless1-1 (cag1-1). In this study, we found that the cag1 gene encodes a homologue of Saccharomyces cerevisiae Tup1...
November 4, 2016: Biology Open
https://www.readbyqxmd.com/read/27778512/multifunctional-gold-nanoclusters-based-nanosurface-energy-transfer-probe-for-real-time-monitoring-of-cell-apoptosis-and-self-evaluating-of-pro-apoptotic-theranostics
#3
Yong Li, Pei Li, Rong Zhu, Chao Luo, Hao Li, Shanfang Hu, Zhou Nie, Yan Huang, Shouzhuo Yao
Bioimaging probes for accurately monitoring apoptosis process have extensive significance for cell biological studies and clinical investigations. Herein, novel multifunctional peptide-tailored gold nanoclusters (AuNCs) have been developed for real-time imaging of caspase-indicated cell apoptosis. The AuNCs nanoprobe was facilely prepared by a one-step peptide-mediated biomineralization with the dye (TRAMA)-tagged peptides specific to caspase 3 as both template agents and the signal switch. Unlike conventional FRET-based fluorescent probes of caspase activity, these nanoprobes relied on the unique quenching effect of AuNCs through the nanosurface energy transfer (NSET) from dye to AuNCs...
November 2, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27716878/data-quality-in-rare-cancers-registration-the-report-of-the-rarecare-data-quality-study
#4
Annalisa Trama, Rafael Marcos-Gragera, Maria Josè Sánchez Pérez, Jan Maarten van der Zwan, Eva Ardanaz, Christine Bouchardy, Juan Manuel Melchor, Carmen Martinez, Riccardo Capocaccia, Massimo Vicentini, Sabine Siesling, Gemma Gatta
PURPOSE: Rare cancers represent 22% of all tumors in Europe; however, the quality of the data of rare cancers may not be as good as the quality of data for common cancer. The project surveillance of rare cancers in Europe (RARECARE) had, among others, the objective of assessing rare cancer data quality in population-based cancer registries (CRs). Eight rare cancers were considered: mesothelioma, liver angiosarcoma, sarcomas, tumors of oral cavity, CNS tumors, germ cell tumors, leukemia, and malignant digestive endocrine tumors...
October 3, 2016: Tumori
https://www.readbyqxmd.com/read/27620947/prostate-cancer-changes-in-clinical-presentation-and-treatments-in-two-decades-an-italian-population-based-study
#5
Annalisa Trama, Laura Botta, Nicola Nicolai, Paolo Giorgi Rossi, Paolo Contiero, Mario Fusco, Michele Lodde, Fabio Pannozzo, Silvano Piffer, Antonella Puppo, Andreas Seeber, Rosario Tumino, Riccardo Valdagni, Gemma Gatta
INTRODUCTION: The incidence of prostate cancer is on the rise in many industrialised countries, including Italy, most likely because of the spread of PSA testing. In Italy, prostate cancer mortality has been dropping since 2000, but it is difficult to understand whether PSA testing is the main reason, considering the role of treatment in prognosis. The objectives of this study were: (1) to describe Italian trends of prostate cancer risk categories and corresponding changes in treatment patterns and (2) to interpret changes in survival over time...
November 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27614694/personalise-medicine-do-not-medicalise-persons-the-case-of-patients-with-stage-i-testis-tumour-undergoing-surveillance
#6
Nicola Nicolai, Annalisa Trama
No abstract text is available yet for this article.
September 7, 2016: European Urology
https://www.readbyqxmd.com/read/27612593/amino-acid-changes-in-the-hiv-1-gp41-membrane-proximal-region-control-virus-neutralization-sensitivity
#7
Todd Bradley, Ashley Trama, Nancy Tumba, Elin Gray, Xiaozhi Lu, Navid Madani, Fatemeh Jahanbakhsh, Amanda Eaton, Shi-Mao Xia, Robert Parks, Krissey E Lloyd, Laura L Sutherland, Richard M Scearce, Cindy M Bowman, Susan Barnett, Salim S Abdool-Karim, Scott D Boyd, Bruno Melillo, Amos B Smith, Joseph Sodroski, Thomas B Kepler, S Munir Alam, Feng Gao, Mattia Bonsignori, Hua-Xin Liao, M Anthony Moody, David Montefiori, Sampa Santra, Lynn Morris, Barton F Haynes
Most HIV-1 vaccines elicit neutralizing antibodies that are active against highly sensitive (tier-1) viruses or rare cases of vaccine-matched neutralization-resistant (tier-2) viruses, but no vaccine has induced antibodies that can broadly neutralize heterologous tier-2 viruses. In this study, we isolated antibodies from an HIV-1-infected individual that targeted the gp41 membrane-proximal external region (MPER) that may have selected single-residue changes in viral variants in the MPER that resulted in neutralization sensitivity to antibodies targeting distal epitopes on the HIV-1 Env...
October 2016: EBioMedicine
https://www.readbyqxmd.com/read/27609377/-establishment-of-traumatic-occlusion-model-in-sprague-dawley-rats
#8
Xian-Zhen Xin, Xu Yang, Bin Wei
PURPOSE: In this study, different methods were used to observe and obtain the most effective one to establish occlusal trauma model in Sprague-Dawley rats. METHODS: SPF male SD rats weighing 150~200 g and aged 10 to 12 weeks were used in this study. The rats' maxillary molars were bonded with stainless steel wire, resin , casting half crown , casting half combined crowns, half crown using selective laser melting (SLM) technology, half combined crowns using SLM technology through Super-bond and Multi-link bonding under general anesthesia...
June 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27521630/taxonomy-and-phylogeny-of-phellinidium-hymenochaetales-basidiomycota-a-redefinition-and-the-segregation-of-coniferiporia-gen-nov-for-forest-pathogens
#9
Li-Wei Zhou, Josef Vlasák, Yu-Cheng Dai
Phellinidium, including 13 accepted polypore species mostly with resupinate basidiocarps, is one of the most aggressive forest pathogenic genera. This genus is characterized by the combination of a monomitic hyphal structure, abundant hyphoid setae in the context and trama, and hyaline and thin-walled basidiospores. To explore the relationships among the species of Phellinidium, especially those between forest pathogens and saprophytes, we examined 29 specimens representing all 13 previously known species from Asia, Europe and America from morphological and phylogenetic perspectives...
August 2016: Fungal Biology
https://www.readbyqxmd.com/read/27502605/accreditation-for-centers-of-sarcoma-surgery
#10
Sergio Sandrucci, Annalisa Trama, Vittorio Quagliuolo, Alessandro Gronchi
Soft-tissue sarcomas (STS) are a heterogeneous group of neoplasms which may be subclassified into over 70 specific histologies and may be distributed throughout the body. Approximately one-half arises in the extremities and one-third arises in the abdomen, pelvis, and retroperitoneum. The diversity and rarity of sarcomas combined with the quite large number of affected patients are factors which underline of the importance of networking in diagnosis, therapy, and research dealing with rare cancers. The expertise of the treating center is one of the most significant factors affecting survival in STS...
August 8, 2016: Updates in Surgery
https://www.readbyqxmd.com/read/27381634/envelope-specific-b-cell-populations-in-african-green-monkeys-chronically-infected-with-simian-immunodeficiency-virus
#11
Ruijun Zhang, David R Martinez, Quang N Nguyen, Justin Pollara, Trina Arifin, Christina Stolarchuk, Andrew Foulger, Josh D Amos, Robert Parks, Jonathon E Himes, Minyue Wang, Regina W Edwards, Ashley M Trama, Nathan Vandergrift, Lisa Colvin, Ken Dewar, Nikoleta Juretic, Jessica Wasserscheid, Guido Ferrari, Hua-Xin Liao, Sallie R Permar
African green monkeys (AGMs) are natural primate hosts of simian immunodeficiency virus (SIV). Interestingly, features of the envelope-specific antibody responses in SIV-infected AGMs are distinct from that of HIV-infected humans and SIV-infected rhesus monkeys, including gp120-focused responses and rapid development of autologous neutralization. Yet, the lack of genetic tools to evaluate B-cell lineages hinders potential use of this unique non-human primate model for HIV vaccine development. Here we define features of the AGM Ig loci and compare the proportion of Env-specific memory B-cell populations to that of HIV-infected humans and SIV-infected rhesus monkeys...
July 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27237614/survival-of-european-adolescents-and-young-adults-diagnosed-with-cancer-in-2000-07-population-based-data-from-eurocare-5
#12
Annalisa Trama, Laura Botta, Roberto Foschi, Andrea Ferrari, Charles Stiller, Emmanuel Desandes, Milena Maria Maule, Franco Merletti, Gemma Gatta
BACKGROUND: Data from EUROCARE have consistently shown lower survival for adolescents and young adults (AYAs; aged 15-24 years) than for children (0-14 years) for most cancers that affect both groups, and modest survival improvements up to 2000-02. AYAs have longer survival than that of adults for most cancers. We used the latest definition of AYAs (aged 15-39 years) and provided estimates of 5-year relative survival for European AYAs with cancer diagnosed in 2000-07, compared with children and adults (40-69 years) with cancer, and assessed survival improvements over time...
July 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27198344/209p-smo-mutation-is-a-strong-negative-prognostic-factor-in-malignant-pleural-mesothelioma
#13
D Signorelli, C Proto, M Ganzinelli, G Lo Russo, L Botta, A Trama, G Pasello, M Tiseo, G Pelosi, M Garassino
No abstract text is available yet for this article.
April 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27122615/initiation-of-immune-tolerance-controlled-hiv-gp41-neutralizing-b-cell-lineages
#14
Ruijun Zhang, Laurent Verkoczy, Kevin Wiehe, S Munir Alam, Nathan I Nicely, Sampa Santra, Todd Bradley, Charles W Pemble, Jinsong Zhang, Feng Gao, David C Montefiori, Hilary Bouton-Verville, Garnett Kelsoe, Kevin Larimore, Phillip D Greenberg, Robert Parks, Andrew Foulger, Jessica N Peel, Kan Luo, Xiaozhi Lu, Ashley M Trama, Nathan Vandergrift, Georgia D Tomaras, Thomas B Kepler, M Anthony Moody, Hua-Xin Liao, Barton F Haynes
Development of an HIV vaccine is a global priority. A major roadblock to a vaccine is an inability to induce protective broadly neutralizing antibodies (bnAbs). HIV gp41 bnAbs have characteristics that predispose them to be controlled by tolerance. We used gp41 2F5 bnAb germline knock-in mice and macaques vaccinated with immunogens reactive with germline precursors to activate neutralizing antibodies. In germline knock-in mice, bnAb precursors were deleted, with remaining anergic B cells capable of being activated by germline-binding immunogens to make gp41-reactive immunoglobulin M (IgM)...
April 27, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27055572/gymnopanella-nothofagi-a-new-genus-and-species-of-gymnopoid-fungi-omphalotaceae-from-chilean-nothofagus-forest
#15
Pablo Andrés Sandoval-Leiva, Jennifer V McDonald, R Greg Thorn
A novel, lignicolous agaric from Nothofagus forests of southern Chile is described as a new genus and species, Gymnopanella nothofagi This taxon falls within the family Omphalotaceae as a sister group to Gymnopus in phylogenetic analyses based on sequences spanning the internal transcribed spacer region and D1/D2 region of nuclear 28S rDNA. Morphologically it is characterized by convex to flabellate basidiomata with distinctly gelatinized trama, pileipellis in the form of a cutis with erect fascicles of cylindrical, spirally incrusted hyphae and nonamyloid, broadly ellipsoid basidiospores...
July 2016: Mycologia
https://www.readbyqxmd.com/read/26951748/italian-cancer-figures-report-2015-the-burden-of-rare-cancers-in-italy
#16
Susanna Busco, Carlotta Buzzoni, Sandra Mallone, Annalisa Trama, Marine Castaing, Francesca Bella, Rosalba Amodio, Sabrina Bizzoco, Tiziana Cassetti, Claudia Cirilli, Rosanna Cusimano, Roberta De Angelis, Mario Fusco, Gemma Gatta, Valerio Gennaro, Adriano Giacomin, Paolo Giorgi Rossi, Lucia Mangone, Salvatore Mannino, Silvia Rossi, Daniela Pierannunzio, Andrea Tavilla, Sandro Tognazzo, Rosario Tumino, Massimo Vicentini, Maria Francesca Vitale, Emanuele Crocetti, Luigino DalMaso
OBJECTIVES This collaborative study, based on data collected by the network of Italian Cancer Registries (AIRTUM), describes the burden of rare cancers in Italy. Estimated number of new rare cancer cases yearly diagnosed (incidence), proportion of patients alive after diagnosis (survival), and estimated number of people still alive after a new cancer diagnosis (prevalence) are provided for about 200 different cancer entities. MATERIALS AND METHODS Data herein presented were provided by AIRTUM population- based cancer registries (CRs), covering nowadays 52%of the Italian population...
January 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/26917456/diagnosis-and-management-of-typical-and-atypical-lung-carcinoids
#17
REVIEW
Sara Pusceddu, Giuseppe Lo Russo, Marianna Macerelli, Claudia Proto, Milena Vitali, Diego Signorelli, Monica Ganzinelli, Paolo Scanagatta, Leonardo Duranti, Annalisa Trama, Roberto Buzzoni, Giuseppe Pelosi, Ugo Pastorino, Filippo de Braud, Marina Chiara Garassino
An estimated 20% to 30% of all neuroendocrine tumours originate in the bronchial tree and lungs. According to the 2015 World Health Organization categorization, these tumours are separated into four subtypes characterized by increasing biological aggressiveness: typical carcinoid, atypical carcinoid, large-cell neuroendocrine carcinoma and small-cell carcinoma. Although typical and atypical lung carcinoids account for less than 1-5% of all pulmonary malignancies, the incidence of these neoplasms has risen significantly in recent decades...
April 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/26818050/thymoma-and-thymic-carcinomas
#18
REVIEW
Marta Scorsetti, Francesco Leo, Annalisa Trama, Rolando D'Angelillo, Danila Serpico, Marianna Macerelli, Paolo Zucali, Gemma Gatta, Marina Chiara Garassino
Thymomas (Ts) and thymic carcinomas (TCs) are rare tumours of the mediastinum with an incidence rate of 1.7/million per year in Europe. Histological classification is based on rate of non-malignant-appearing thymic epithelial cells and proportions of lymphocytes (A, AB, B1, B2, B3, and C), while staging system concerns localisation of the involved areas. Surgery is the mainstay of treatment with a 10-year survival of 80%, 78%, 75%, and 42% for stages I, II, III and IV, respectively, with an R0 resection. Radiotherapy has a role in selected cases (stage III patients or R1-2 residual) and platinum-based chemotherapy remains the standard of care for patients with advanced disease...
March 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/26242599/the-function-and-affinity-maturation-of-hiv-1-gp120-specific-monoclonal-antibodies-derived-from-colostral-b-cells
#19
T L Jeffries, C R Sacha, J Pollara, J Himes, F H Jaeger, S M Dennison, E McGuire, E Kunz, J A Eudailey, A M Trama, C LaBranche, G G Fouda, K Wiehe, D C Montefiori, B F Haynes, H-X Liao, G Ferrari, S M Alam, M A Moody, S R Permar
Despite the risk of transmitting HIV-1, mothers in resource-poor areas are encouraged to breastfeed their infants because of beneficial immunologic and nutritional factors in milk. Interestingly, in the absence of antiretroviral prophylaxis, the overwhelming majority of HIV-1-exposed, breastfeeding infants are naturally protected from infection. To understand the role of HIV-1 envelope (Env)-specific antibodies in breast milk in natural protection against infant virus transmission, we produced 19 HIV-1 Env-specific monoclonal antibodies (mAbs) isolated from colostrum B cells of HIV-1-infected mothers and investigated their specificity, evolution, and anti-HIV-1 functions...
March 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/26229114/hiv-1-vaccines-diversion-of-hiv-1-vaccine-induced-immunity-by-gp41-microbiota-cross-reactive-antibodies
#20
Wilton B Williams, Hua-Xin Liao, M Anthony Moody, Thomas B Kepler, S Munir Alam, Feng Gao, Kevin Wiehe, Ashley M Trama, Kathryn Jones, Ruijun Zhang, Hongshuo Song, Dawn J Marshall, John F Whitesides, Kaitlin Sawatzki, Axin Hua, Pinghuang Liu, Matthew Z Tay, Kelly E Seaton, Xiaoying Shen, Andrew Foulger, Krissey E Lloyd, Robert Parks, Justin Pollara, Guido Ferrari, Jae-Sung Yu, Nathan Vandergrift, David C Montefiori, Magdalena E Sobieszczyk, Scott Hammer, Shelly Karuna, Peter Gilbert, Doug Grove, Nicole Grunenberg, M Juliana McElrath, John R Mascola, Richard A Koup, Lawrence Corey, Gary J Nabel, Cecilia Morgan, Gavin Churchyard, Janine Maenza, Michael Keefer, Barney S Graham, Lindsey R Baden, Georgia D Tomaras, Barton F Haynes
An HIV-1 DNA prime vaccine, with a recombinant adenovirus type 5 (rAd5) boost, failed to protect from HIV-1 acquisition. We studied the nature of the vaccine-induced antibody (Ab) response to HIV-1 envelope (Env). HIV-1-reactive plasma Ab titers were higher to Env gp41 than to gp120, and repertoire analysis demonstrated that 93% of HIV-1-reactive Abs from memory B cells responded to Env gp41. Vaccine-induced gp41-reactive monoclonal antibodies were non-neutralizing and frequently polyreactive with host and environmental antigens, including intestinal microbiota (IM)...
August 14, 2015: Science
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