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Spinal manipulation therapy

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https://www.readbyqxmd.com/read/28073291/future-of-raav-gene-therapy-platform-for-rnai-gene-editing-and-beyond
#1
Paul Valdmanis, Mark A Kay
The use of recombinant adeno-associated viruses (rAAVs) ushered in a new millennium of gene transfer for therapeutic treatment of a number of conditions including congenital blindness, hemophilia, and spinal muscular atrophy (SMA). rAAV vectors have remarkable staying power from a therapeutic standpoint withstanding several ebbs and flows. As new technologies such as clustered regularly interspaced short palindromic repeat (CRISPR) genome editing emerge, it is now the delivery tool - the AAV vector - that is the stalwart...
January 10, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28055091/spinal-manipulation-and-mobilization-therapy-for-cervicogenic-headache
#2
Michael A Seffinger, Melissa Yunting Tang
No abstract text is available yet for this article.
January 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28042118/post-operative-neuropathy-after-total-hip-arthroplasty
#3
E P Su
Nerve palsy is a well-described complication following total hip arthroplasty, but is highly distressing and disabling. A nerve palsy may cause difficulty with the post-operative rehabilitation, and overall mobility of the patient. Nerve palsy may result from compression and tension to the affected nerve(s) during the course of the operation via surgical manipulation and retractor placement, tension from limb lengthening or compression from post-operative hematoma. In the literature, hip dysplasia, lengthening of the leg, the use of an uncemented femoral component, and female gender are associated with a greater risk of nerve palsy...
January 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28025254/shaping-the-output-of-lumbar-flexor-motoneurons-by-sacral-neuronal-networks
#4
Meir Cherniak, Lili Anglister, Aharon Lev-Tov
: The ability to improve motor function in spinal cord injury patients by reactivating spinal central pattern generators (CPGs) requires the elucidation of neurons and pathways involved in activation and modulation of spinal networks in accessible experimental models. Previously we reported on adrenoceptor-dependent sacral control of lumbar-flexor motoneuron firing in newborn rats. The current work focuses on clarification of the circuitry and connectivity involved in this unique modulation and its potential use...
December 26, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28017603/guideline-for-reporting-interventions-on-spinal-manipulative-therapy-consensus-on-interventions-reporting-criteria-list-for-spinal-manipulative-therapy-circle-smt
#5
Ruud Groeneweg, Sidney M Rubinstein, Rob A B Oostendorp, Raymond W J G Ostelo, Maurits W van Tulder
OBJECTIVE: The aim of the Consensus on Interventions Reporting Criteria List for Spinal Manipulative Therapy (CIRCLe SMT) study was to develop a criteria list for reporting spinal manipulative therapy (SMT). METHODS: A Delphi procedure was conducted from September 2011 to April 2013 and consisted of international experts in the field of SMT. The authors formed a steering committee and invited participants, selected initial items, structured the comments of the participants after each Delphi round, and formulated the feedback...
December 22, 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27965621/upper-trunk-brachial-plexus-palsy-following-chiropractic-manipulation
#6
John Cunningham, Wayne Hoskins, Scott Ferris
INTRODUCTION: Upper trunk brachial plexus palsy can result from high-energy trauma and has never been reported following spinal manipulation. BACKGROUND: The case is presented of a patient who developed an acute brachial plexus upper trunk palsy following spinal manipulative therapy. DISCUSSION: Discussion is made on the incidence of complications following manipulation and recommendations to prospectively capture all serious complications...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27912991/malignant-spinal-cord-compression-adapting-conventional-rehabilitation-approaches
#7
REVIEW
Lisa Marie Ruppert
Spinal tumors are classically grouped into 3 categories: extradural, intradural extramedullary, and intradural intramedullary. Spinal tumors may cause spinal cord compression and vascular compromise resulting in pain or neurologic compromise. They may also alter the architecture of the spinal column, resulting in spinal instability. Oncologic management of spinal tumors varies according to the stability of the spine, neurologic status, and presence of pain. Treatment options include surgical intervention, radiation therapy, chemotherapy, and hormonal manipulation...
February 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27911127/immediate-and-lasting-effects-of-a-thoracic-spine-manipulation-in-a-patient-with-signs-of-cervical-radiculopathy-and-upper-extremity-hyperalgesia-a-case-report
#8
Beth K Deschenes, Jason Zafereo
Patients with cervical radiculopathy (CR) may present with accompanying symptoms of hyperalgesia, allodynia, heaviness in the arm, and non-segmental pain that do not appear to be related to a peripheral spinal nerve. These findings may suggest the presence of central or autonomic nervous system involvement, requiring a modified management approach. The purpose of this case report is to describe the treatment of a patient with signs of CR and upper extremity (UE) hyperalgesia who had a significant decrease in her UE pain and hypersensitivity after a single thoracic spine manipulation (TSM)...
January 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/27905508/tissue-loading-created-during-spinal-manipulation-in-comparison-to-loading-created-by-passive-spinal-movements
#9
Martha Funabashi, Gregory N Kawchuk, Albert H Vette, Peter Goldsmith, Narasimha Prasad
Spinal manipulative therapy (SMT) creates health benefits for some while for others, no benefit or even adverse events. Understanding these differential responses is important to optimize patient care and safety. Toward this, characterizing how loads created by SMT relate to those created by typical motions is fundamental. Using robotic testing, it is now possible to make these comparisons to determine if SMT generates unique loading scenarios. In 12 porcine cadavers, SMT and passive motions were applied to the L3/L4 segment and the resulting kinematics tracked...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27888138/the-quality-of-placebos-used-in-randomized-controlled-trials-of-lumbar-and-pelvic-joint-thrust-manipulation-a-systematic-review
#10
REVIEW
Aaron A Puhl, Christine J Reinhart, Jon B Doan, Howard Vernon
BACKGROUND CONTEXT: Spinal manipulative therapy (SMT) has been attributed with substantial non-specific effects. Accurate assessment of the non-specific effects of SMT relies on high-quality studies with low risk of bias that compare with appropriate placebos. PURPOSE: This review aims to characterize the types and qualities of placebo control procedures used in controlled trials of manually applied, lumbar and pelvic (LP)-SMT, and to evaluate the assessment of subject blinding and expectations...
November 22, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27857638/changes-in-muscle-spasticity-in-patients-with-cerebral-palsy-after-spinal-manipulation-case-series
#11
Oleh Kachmar, Taras Voloshyn, Mykhailo Hordiyevych
OBJECTIVE: The purpose of this case series was to report quantitative changes in wrist muscle spasticity in children with cerebral palsy after 1 spinal manipulation (SM) and a 2-week course of treatment. METHODS: Twenty-nine patients, aged 7 to 18 years, with spastic forms of cerebral palsy and without fixed contracture of the wrist, were evaluated before initiation of treatment, after 1 SM, and at the end of a 2-week course of treatment. Along with daily SM, the program included physical therapy, massage, reflexotherapy, extremity joint mobilization, mechanotherapy, and rehabilitation computer games for 3 to 4 hours' duration...
December 2016: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/27822362/does-case-misclassification-threaten-the-validity-of-studies-investigating-the-relationship-between-neck-manipulation-and-vertebral-artery-dissection-stroke-yes
#12
Jessica K Paulus, David E Thaler
BACKGROUND: For patients and health care providers who are considering spinal manipulative therapy of the neck, it is crucial to establish if it is a trigger for cervical artery dissection and/or stroke, and if it is, the magnitude of the risk. DISCUSSION: We discuss the biological plausibility of how neck manipulation could cause cervical artery dissection. We also discuss how case misclassification threatens the validity of influential published studies that have investigated the relationship between neck manipulation and dissection...
2016: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/27814850/t4-syndrome-a-distinct-theoretical-concept-or-elusive-clinical-entity-a-case-report
#13
Patricia Miyuki Hirai, Oliver P Thomson
T4 syndrome has existed as a clinical concept for more than three decades and it has been identified as a source of upper extremity (UE) symptoms. This case report explores the clinical reasoning in the diagnoses and management of a patient with symptoms consistent with T4-type syndrome and critically discusses the concept of T4 syndrome using recent research to help explain the clinical presentation. Manual therapy treatment focused on stimulation of the sympathetic ganglia, decreasing local upper thoracic pain and UE referral pattern noted during passive examination...
October 2016: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/27809905/peyton-s-four-step-approach-for-teaching-complex-spinal-manipulation-techniques-a-prospective-randomized-trial
#14
Gertraud Gradl-Dietsch, Cavan Lübke, Klemens Horst, Melanie Simon, Ali Modabber, Tolga T Sönmez, Ralf Münker, Sven Nebelung, Matthias Knobe
BACKGROUND: The objectives of this prospective randomized trial were to assess the impact of Peyton's four-step approach on the acquisition of complex psychomotor skills and to examine the influence of gender on learning outcomes. METHODS: We randomly assigned 95 third to fifth year medical students to an intervention group which received instructions according to Peyton (PG) or a control group, which received conventional teaching (CG). Both groups attended four sessions on the principles of manual therapy and specific manipulative and diagnostic techniques for the spine...
November 3, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27799691/the-immediate-effects-of-spinal-thoracic-manipulation-on-respiratory-functions
#15
Doo Chul Shin, Yong Woo Lee
[Purpose] The purpose of this study was to investigate the effects of thoracic spinal manipulation therapy on respiratory function including forced vital capacity and forced expiratory volume in one second in young healthy individuals. [Subjects and Methods] Thirty young healthy subjects recruited from a local university participated in this study. Subjects were randomly allocated into an experimental group (n=15) and a control group (n=15). The experimental group received thoracic spinal manipulation and the control group received placebo thoracic spinal manipulation...
September 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27793133/the-quantity-and-quality-of-complementary-and-alternative-medicine-clinical-practice-guidelines-on-herbal-medicines-acupuncture-and-spinal-manipulation-systematic-review-and-assessment-using-agree-ii
#16
Jeremy Y Ng, Laurel Liang, Anna R Gagliardi
BACKGROUND: Complementary and alternative medicine (CAM) use is often not disclosed by patients, and can be unfamiliar to health care professionals. This may lead to underuse of beneficial CAM therapies, and overuse of other CAM therapies with little proven benefit or known contraindications. No prior research has thoroughly evaluated the credibility of knowledge-based resources. The purpose of this research was to assess the quantity and quality of CAM guidelines. METHODS: A systematic review was conducted to identify CAM guidelines...
October 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27751598/complementary-therapies-in-addition-to-medication-for-patients-with-nonchronic-nonradicular-low-back-pain-a-systematic-review
#17
Samantha Rothberg, Benjamin W Friedman
BACKGROUND: A total of 2.7 million patients present to US emergency departments annually for management of low back pain (LBP). Despite optimal medical therapy, more than 50% remain functionally impaired 3 months later. We performed a systematic review to address the following question: Among patients with nonchronic LBP, does spinal manipulation, massage, exercise, or yoga, when combined with standard medical therapy, improve pain and functional outcomes more than standard medical therapy alone? METHODS: We used published searches to identify relevant studies, supplemented with our own updated search...
January 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27743984/non-viral-xylosyltransferase-1-sirna-delivery-as-an-effective-alternative-to-chondroitinase-in-an-in-vitro-model-of-reactive-astrocytes
#18
Mohammad T Abu-Rub, Ben Newland, Michelle Naughton, Wenxin Wang, Siobhan McMahon, Abhay Pandit
Reactive astrocytosis and the subsequent glial scar is ubiquitous to injuries of the central nervous system, especially spinal cord injury (SCI) and primarily serves to protect against further damage, but is also a prominent inhibitor of regeneration. Manipulating the glial scar by targeting chondroitin sulfate proteoglycans (CSPGs) has been the focus of much study as a means to improve axon regeneration and subsequently functional recovery. In this study we investigate the ability of small interfering RNA (siRNA) delivered by a non-viral polymer vector to silence the rate-limiting enzyme involved in CSPG synthesis...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27736748/rat-models-of-spinal-cord-injury-from-pathology-to-potential-therapies
#19
Jacob Kjell, Lars Olson
A long-standing goal of spinal cord injury research is to develop effective spinal cord repair strategies for the clinic. Rat models of spinal cord injury provide an important mammalian model in which to evaluate treatment strategies and to understand the pathological basis of spinal cord injuries. These models have facilitated the development of robust tests for assessing the recovery of locomotor and sensory functions. Rat models have also allowed us to understand how neuronal circuitry changes following spinal cord injury and how recovery could be promoted by enhancing spontaneous regenerative mechanisms and by counteracting intrinsic inhibitory factors...
October 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27713576/neck-pain-in-children-a-retrospective-case-series
#20
Jocelyn Cox, Christine Davidian, Silvano Mior
INTRODUCTION: Spinal pain in the paediatric population is a significant health issue, with an increasing prevalence as they age. Paediatric patients attend for chiropractor care for spinal pain, yet, there is a paucity of quality evidence to guide the practitioner with respect to appropriate care planning. METHODS: A retrospective chart review was used to describe chiropractic management of paediatric neck pain. Two researchers abstracted data from 50 clinical files that met inclusion criteria from a general practice chiropractic office in the Greater Toronto Area, Canada...
September 2016: Journal of the Canadian Chiropractic Association
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