Xinyue Li, Kai Ma, Tiantian Tian, Huan Pang, Tianxiang Liu, Meng Li, Jiali Li, Zhixuan Luo, Huiyuan Hu, Shanshan Hou, Jing Yu, Qiaohong Hou, Xiuling Song, Chao Zhao, Haiying Du, Jinhua Li, Zhongjun Du, Minghua Jin
Methylmercury (MeHg) is a global environmental pollutant with neurotoxicity, which can easily crosses the blood-brain barrier and cause irreversible damage to the human central nervous system (CNS). CNS inflammation and autophagy are known to be involved in the pathology of neurodegenerative diseases. Meanwhile, MeHg has the potential to induce microglia-mediated neuroinflammation as well as autophagy. This study aims to further explore the exact molecular mechanism of MeHg neurotoxicity. We conducted in vitro studies using BV2 microglial cell from the central nervous system of mice...
April 4, 2024: Environment International