keyword
https://read.qxmd.com/read/38535441/the-peptide-lltragl-derived-from-rapana-venosa-exerts-protective-effect-against-inflammatory-bowel-disease-in-zebrafish-model-by-regulating-multi-pathways
#1
JOURNAL ARTICLE
Yongna Cao, Fenghua Xu, Qing Xia, Kechun Liu, Houwen Lin, Shanshan Zhang, Yun Zhang
Inflammatory bowel disease (IBD) is a chronic inflammatory bowel disease with unknown pathogenesis which has been gradually considered a public health challenge worldwide. Peptides derived from Rapana venosa have been shown to have an anti-inflammatory effect. In this study, peptide LLTRAGL derived from Rapana venosa was prepared by a solid phase synthesis technique. The protective effects of LLTRAGL were studied in a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced zebrafish colitis model. The underlying mechanisms of LLTRAGL were predicted and validated by transcriptome, real-time quantitative PCR assays and molecular docking...
February 22, 2024: Marine Drugs
https://read.qxmd.com/read/38533515/tigit-acts-as-an-immune-checkpoint-upon-inhibition-of-pd1-signaling-in-autoimmune-diabetes
#2
JOURNAL ARTICLE
Prerak Trivedi, Gaurang Jhala, David J De George, Chris Chiu, Claudia Selck, Tingting Ge, Tara Catterall, Lorraine Elkerbout, Louis Boon, Nicole Joller, Thomas W Kay, Helen E Thomas, Balasubramanian Krishnamurthy
INTRODUCTION: Chronic activation of self-reactive T cells with beta cell antigens results in the upregulation of immune checkpoint molecules that keep self-reactive T cells under control and delay beta cell destruction in autoimmune diabetes. Inhibiting PD1/PD-L1 signaling results in autoimmune diabetes in mice and humans with pre-existing autoimmunity against beta cells. However, it is not known if other immune checkpoint molecules, such as TIGIT, can also negatively regulate self-reactive T cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533385/altered-ocular-surface-microbiota-in-obesity-a-case-control-study
#3
JOURNAL ARTICLE
Chenghong Liang, Limin Wang, Xiudan Wang, Yifan Jia, Qinyuan Xie, Lingyun Zhao, Huijuan Yuan
PURPOSE: This study aimed to investigate the composition of ocular surface microbiota in patients with obesity. METHODS: This case-control study, spanning from November 2020 to March 2021 at Henan Provincial People's Hospital, involved 35 patients with obesity and an equivalent number of age and gender-matched healthy controls. By employing 16S rRNA sequencing, this study analyzed the differences in ocular surface microbiota between the two groups. The functional prediction analysis of the ocular surface microbiota was conducted using PICRUSt2...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38530519/therapeutic-effect-of-levetiracetam-against-thioacetamide-induced-hepatic-encephalopathy-through-inhibition-of-oxidative-stress-and-downregulation-of-nf-%C3%AE%C2%BAb-nlrp3-inos-no-pro-inflammatory-cytokines-and-apoptosis
#4
JOURNAL ARTICLE
Keyvan Amirshahrokhi, Mahsa Imani
Hepatic encephalopathy (HE) is a serious brain disorder which associated with neurological and psychiatric manifestations. Oxidative stress and neuroinflammation and apoptosis play main roles in the development of brain damage in HE. Levetiracetam is an antiseizure drug with established antioxidant and anti-inflammatory activities. In the present study we investigated the therapeutic effects of levetiracetam against brain injury in HE and its underlying mechanisms of action. Male C57BL/6 mice were subjected to the induction of HE by the injection of thioacetamide (200 mg/kg) for 2 days...
March 26, 2024: Inflammation
https://read.qxmd.com/read/38529047/identification-and-validation-of-the-pyroptosis-related-hub-gene-signature-and-the-associated-regulation-axis-in-diabetic-keratopathy
#5
JOURNAL ARTICLE
Yi Cui, Li Wang, Wentao Liang, Li Huang, Shuting Zhuang, Hong Shi, Nuo Xu, Jianzhang Hu
BACKGROUND: Diabetic keratopathy (DK) poses a significant challenge in diabetes mellitus, yet its molecular pathways and effective treatments remain elusive. The aim of our research was to explore the pyroptosis-related genes in the corneal epithelium of the streptozocin-induced diabetic rats. METHODS: After sixteen weeks of streptozocin intraperitoneal injection, corneal epithelium from three diabetic rats and three normal groups underwent whole-transcriptome sequencing...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38526919/cxcl13-cxcr5-promote-chronic-postsurgical-pain-and-astrocyte-activation-in-rats-by-targeting-nlrp3
#6
JOURNAL ARTICLE
Hongda Yi, Bin Zhu, Caihong Zheng, Zhenyang Ying, Mei Cheng
Chronic postsurgical pain (CPSP) with high incidence negatively impacts the quality of life. X-C motif chemokine 13 (CXCL13) has been associated with postsurgery inflammation and exacerbates neuropathic pain in patients with CPSP. This study was aimed to illustrate the relationship between CXCL13 and nod-like receptor protein-3 (NLRP3), which is also involved in CPSP. A CPSP model was constructed by skin/muscle incision and retraction (SMIR) in right medial thigh, and the rats were divided into three groups: Sham, SMIR, and SMIR + anti-CXCL13 (intrathecally injected with anti-CXCL13 antibody)...
March 8, 2024: Neuroreport
https://read.qxmd.com/read/38522660/electroacupuncture-alleviates-post-stroke-cognitive-impairment-through-inhibiting-mir-135a-5p-mtor-nlrp3-axis-mediated-autophagy
#7
JOURNAL ARTICLE
Jianchang Luo, Jiawang Lang, Wenbin Xu, Luodan Wang, Zhipeng Zhao, Jie Jia, Boxu Lang
Post-stroke cognitive impairment is a significant challenge with limited treatment options. Electroacupuncture (EA) has shown promise in improving cognitive function after stroke. Our study explores the underlying mechanism of EA in alleviating cognitive impairment through the inhibition of autophagy. We utilized a rat model of stroke induced by middle cerebral artery occlusion (MCAO) to evaluate the efficacy of EA. Treatment with EA was observed to markedly improve cognitive function and reduce inflammation in MCAO rats, as evidenced by decreased neurological deficit scores, shorter latencies in the water maze test, and diminished infarct volumes...
March 22, 2024: Neuroscience
https://read.qxmd.com/read/38519940/total-iridoid-glycoside-extract-of-lamiophlomis-rotata-benth-kudo-accelerates-diabetic-wound-healing-by-the-nrf2-cox2-axis
#8
JOURNAL ARTICLE
Xiaoyu Geng, Ying Wang, Huan Li, Liang Song, Chen Luo, Xiaojie Gu, Haixin Zhong, Huilin Chen, Xinzhu Chen, Jianwei Wang, Zheng Pan
BACKGROUND: Lamiophlomis rotata (Benth.) Kudo (L. rotata), the oral Traditional Tibetan herbal medicine, is adopted for treating knife and gun wounds for a long time. As previously demonstrated, total iridoid glycoside extract of L. rotata (IGLR) induced polarization of M2 macrophage to speed up wound healing. In diabetic wounds, high levels inflammatory and chemotactic factors are usually related to high reactive oxygen species (ROS) levels. As a ROS target gene, nuclear factor erythroid 2-related factor 2 (NRF2), influences the differentiation of monocytes to M1/M2 macrophages...
March 22, 2024: Chinese Medicine
https://read.qxmd.com/read/38512440/investigation-of-shared-genetic-features-and-related-mechanisms-between-diabetes-and-tuberculosis
#9
JOURNAL ARTICLE
Lifei Huang, Zhihao Liu, Xiaodong Lv, Yahong Sun
OBJECTIVE: This study aimed to integrate bioinformatics technology to explore shared hub genes and related mechanisms between diabetes and tuberculosis and to provide a theoretical basis for revealing the disease mechanisms in patients with both diabetes and tuberculosis. METHODS: Differentially expressed genes and Venn analysis were used to identify shared genes between diabetes and tuberculosis. PPI network analysis was used to screen key hub genes. GO and KEGG analyses were used to analyze the potential biological functions of these key hub genes...
March 21, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38510083/case-report-identification-of-a-card8-variant-in-all-three-patients-with-pfapa-syndrome-complicated-with-kawasaki-disease
#10
Haruhiko Nakamura, Atsuo Kikuchi, Hideyuki Sakai, Miki Kamimura, Yohei Watanabe, Ryoichi Onuma, Jun Takayama, Gen Tamiya, Yoichi Mashimo, Ryota Ebata, Hiromichi Hamada, Tomohiro Suenaga, Yoshihiro Onouchi, Satoru Kumaki
BACKGROUND: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA syndrome), and Kawasaki disease (KD) are both considered to be disorders of the innate immune system, and the potential role of inflammasome activation in the immunopathogenesis of both diseases has been previously described. CASE PRESENTATION: Herein, we report the clinical courses of three patients who presented a rare combination of PFAPA syndrome and KD. Two patients who presented KD later developed the PFAPA syndrome, of whom one developed recurrent KD 2 years after the initial diagnosis...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38506417/anti-inflammatory-effect-of-echinacoside-in-collagen-induced-arthritis-via-nrf2-drp1-pathway
#11
JOURNAL ARTICLE
Xiaoyan Wang, Lingxinyu Li, Mengyun Zhang, Ruike Ji, Na Li, Kun Wang, Zhufeng Chen
BACKGROUND: Oxidative damage plays an important role in the progression of rheumatoid arthritis (RA). Emerging research evidence suggests that natural antioxidants may effectively ameliorate this disease. OBJECTIVES: To investigate the therapeutic effect of echinacoside (ECH) in a collagen-induced arthritis (CIA) mouse model and thus elucidate the underlying molecular mechanism in RA. MATERIAL AND METHODS: Collagen-induced arthritis mice were intraperitoneally administered 1% dimethyl sulfoxide (DMSO) (control) or 0...
March 20, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38505967/dictyophora-indusiata-polysaccharide-mediates-priming-of-the-nlrp3-inflammasome-activation-via-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-to-exert-immunostimulatory-effects
#12
JOURNAL ARTICLE
Youyi Liu, Huanxiao Zhang, Yuxuan Li, Hanqian Zha, Yujie Gao, Hui Chen, Yalin Wang, Tongxin Zhou, Chao Deng
Dictyophora indusiata, commonly known as bamboo fungus, is a type of edible mushroom that is highly popular worldwide for its rich flavor and nutritional value. It is also recognized for its pharmaceutical efficacy, with medicinal benefits attributed to its consumption. One of the most important components of Dictyophora indusiata is polysaccharide, which has been acknowledged as a promising regulator of biological response due to its immunostimulatory and anti-inflammatory properties. However, the specific roles of polysaccharide in modulating the NOD-like receptor protein 3 (NLRP3) inflammasome activation within macrophages remain relatively under-researched...
March 2024: Journal of Applied Biomedicine
https://read.qxmd.com/read/38504536/yemazhui-ameliorates-lipopolysaccharide-induced-acute-lung-injury-modulation-of-the-toll-like-receptor-4-nuclear-factor-kappa-b-nod-like-receptor-family-pyrin-domain-containing-3-protein-signaling-pathway-and-intestinal-flora-in-rats
#13
JOURNAL ARTICLE
Ren Li, Hai Yang, Yang Xue, Luo Xianqin
OBJECTIVE: To investigate the impact of Yemazhui ( Herba Eupatorii Lindleyani , HEL) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) and explore its underlying mechanism in vivo . METHODS: The chemical constituents of HEL were analyzed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry method. Then, HEL was found to suppress LPS-induced ALI in vivo . Six-week-old male Sprague-Dawley rats were randomly divided into 6 groups: control, LPS, Dexamethasone (Dex), HEL low dose 6 g/kg (HEL-L), HEL medium dose 18 g/kg (HEL-M) and HEL high dose 54 g/kg (HEL-H) groups...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38503169/dt-13-attenuates-inflammation-by-inhibiting-nlrp3-inflammasome-related-genes-in-raw264-7-macrophages
#14
JOURNAL ARTICLE
Shikha Raina, Emely Hübner, Esther Samuel, Gregor Nagel, Hendrik Fuchs
Plant derived saponins or other glycosides are widely used for their anti-inflammatory, antioxidant, and anti-viral properties in therapeutic medicine. In this study, we focus on understanding the function of the less known steroidal saponin from the roots of Liriope muscari L. H. Bailey - saponin C (also known as DT-13) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages in comparison to the well-known saponin ginsenoside Rk1 and anti-inflammatory drug dexamethasone. We proved that DT-13 reduces LPS-induced inflammation by inhibiting nitric oxide (NO) production, interleukin-6 (IL-6) release, cycloxygenase-2 (COX-2), tumour necrosis factor-alpha (TNF-α) gene expression, and nuclear factor kappa-B (NFκB) translocation into the nucleus...
March 13, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38502592/immunological-landscape-of-retinal-ischemia-reperfusion-injury-insights-into-resident-and-peripheral-immune-cell-responses
#15
REVIEW
Shan He, Cuiying Liu, Changhong Ren, Heng Zhao, Xuxiang Zhang
Retinal ischemia-reperfusion injury (RIRI) is a complex condition characterized by immune cell-mediated inflammation and consequent neuronal damage. This review delves into the immune response mechanisms in RIRI, particularly emphasizing the roles played by resident and peripheral immune cells. It highlights the pivotal role of microglia, the primary resident immune cells, in exacerbating neuroinflammation and neuronal damage through their activation and subsequent release of pro-inflammatory mediators. Additionally, the review explores the contributions of other glial cell types, such as astrocytes and Müller cells, in modulating the immune response within the retinal environment...
March 1, 2024: Aging and Disease
https://read.qxmd.com/read/38501146/ephrin-b1-regulates-inflammatory-pathways-in-retinal-m%C3%A3-ller-cells
#16
JOURNAL ARTICLE
Li Liu, Youde Jiang, Mohamed Al-Shabrawey, Jena J Steinle
The role of inflammation has been accepted as a factor in the complications of diabetic retinopathy. Discovery of the upstream regulation of these inflammatory factors has remained a challenge. In this study, we explored the actions of ephrin B1 in retinal Müller cells and their actions on inflammatory proteins. We used diabetic human and mouse samples, as well as Müller cells in culture to measure ephrin B1 in Müller cells. We then generated Müller cell specific ephrin B1 knockout mice...
2024: Journal of diabetes and clinical research
https://read.qxmd.com/read/38498304/design-and-synthesis-of-3-2-h-chromen-3-yl-5-aryl-1-2-4-oxadiazole-derivatives-as-novel-toll-like-receptor-2-1-agonists-that-inhibit-lung-cancer-in-vitro-and-in-vivo
#17
JOURNAL ARTICLE
Yijie Wang, Xu Cheng, Xinru Liu, Jing Xu, Lin Wang, Shouguo Zhang, Shuchen Liu, Tao Peng
Toll-like receptor (TLR) 2 is a transmembrane receptor that participates in the innate immune response by forming a heterodimer with TLR1 or TLR6. TLR2 agonists play an important role in tumor therapy. Herein, we synthesized a series of 3-(2 H -chromen-3-yl)-5-aryl-1,2,4-oxadiazole derivatives and identified WYJ-2 as a potent small and selective molecule agonist of TLR2/1, with an EC50 of 18.57 ± 0.98 nM in human TLR2 and TLR1 transient-cotransfected HEK 293T cells. WYJ-2 promoted the formation of TLR2/1 heterodimers and activated the nuclear factor kappa B (NF-κB) signaling pathway...
March 18, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38497930/er-stress-promotes-mitochondrial-calcium-overload-and-activates-the-ros-nlrp3-axis-to-mediate-fatty-liver-ischemic-injury
#18
JOURNAL ARTICLE
Fei Li, Zhu Guan, Yiyun Gao, Yan Bai, Xinyu Zhan, Xingyue Ji, Jian Xu, Haoming Zhou, Zhuqing Rao
BACKGROUND: Fatty livers are widely accepted as marginal donors for liver transplantation but are more susceptible to liver ischemia and reperfusion (IR) injury. Increased macrophage-related inflammation plays an important role in the aggravation of fatty liver IR injury. Here, we investigate the precise mechanism by which endoplasmic reticulum (ER) stress activates macrophage NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) signaling by regulating mitochondrial calcium overload in fatty liver IR...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38492338/butyrate-alleviates-alcoholic-liver-disease-associated-inflammation-through-macrophage-regulation-and-polarization-via-the-hdac1-mir-155-axis
#19
JOURNAL ARTICLE
Lina Zhang, Zhiguo Ma, Xiaoxu Zhang, Jing Wang, Wenyan Tian, Yi Ren, Yajuan Liu, Ting Wang, Yiwei Li, Yuanyuan Liu, Wenke Shen, Ting Li, Jian Liu, Junbai Ma, Xiaoxia Zhang, Shaoqi Yang, Hao Wang
BACKGROUND: We recently found that butyrate could ameliorate inflammation of alcoholic liver disease (ALD) in mice. However, the exact mechanism remains incompletely comprehended. Here, we examined the role of butyrate on ALD-associated inflammation through macrophage (Mψ) regulation and polarization using in vivo and in vitro experiments. METHODS: For in vivo experiments, C57BL/6J mice were fed modified Lieber-DeCarli liquid diets supplemented with or without ethanol and sodium butyrate (NaB)...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38490287/study-on-the-therapeutic-mechanism-of-hj-granules-in-a-rat-model-of-urinary-tract-infection-caused-by-escherichia-coli
#20
JOURNAL ARTICLE
Shan Cao, Shuangrong Gao, Chen Ni, Yingli Xu, Bo Pang, Jingsheng Zhang, Yu Zhang, Yaxin Wang, Zihan Geng, Shurang Li, Ronghua Zhao, Bing Han, Xiaolan Cui, Yanyan Bao
ETHNOPHARMACOLOGICAL RELEVANCE: Urinary tract infections (UTIs) are globally prevalent infectious diseases, predominantly caused by uropathogenic Escherichia coli (UPEC). The misuse of antibiotics has led to the emergence of several drug-resistant strains. Traditional Chinese Medicine (TCM) has its own advantages in the treatment of UTIs. HJ granules is a herbal formula used for the treatment of UTIs. However, its mechanism of action is not clear. AIM OF THE STUDY: The aim of this study was to investigate the therapeutic efficacy and mechanism of action of HJ granules in a rat model of UTI caused by Escherichia coli (E coli) CFT073...
March 13, 2024: Journal of Ethnopharmacology
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