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https://www.readbyqxmd.com/read/28817808/ppar%C3%AE-agonist-stimulated-angiogenesis-by-improving-endothelial-precursor-cell-function-via-a-nlrp3-inflammasome-pathway
#1
Yaping Deng, Xue Han, Zheng Yao, Yuannan Sun, Jiawen Yu, Jian Cai, Guofei Ren, Guojun Jiang, Feng Han
BACKGROUND: Impaired wound healing is a common complication of diabetes and is the leading cause of lower extremity amputation. Treatment with fenofibrate, a peroxisome proliferators-activated receptor α (PPARα) agonist, was associated with a lower risk of amputations, particularly minor amputations without known large-vessel diseases, probably through non-lipid mechanisms. The current study aimed to test our hypothesis that fenofibrate stimulates angiogenesis and restores endothelial precursor cell (EPC) function via inhibiting Nod-like receptor protein 3 (NLRP3) inflammasome in streptozotocin (STZ)-induced diabetic mice...
August 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28808003/signaling-from-the-plasma-membrane-localized-plant-immune-receptor-rpm1-requires-self-association-of-the-full-length-protein
#2
Farid El Kasmi, Eui-Hwan Chung, Ryan G Anderson, Jinyue Li, Li Wan, Timothy K Eitas, Zhiyong Gao, Jeffery L Dangl
Plants evolved intracellular immune receptors that belong to the NOD-like receptor (NLR) family to recognize the presence of pathogen-derived effector proteins. NLRs possess an N-terminal Toll-like/IL-1 receptor (TIR) or a non-TIR domain [some of which contain coiled coils (CCs)], a central nucleotide-binding (NB-ARC) domain, and a C-terminal leucine-rich repeat (LRR). Activation of NLR proteins results in a rapid and high-amplitude immune response, eventually leading to host cell death at the infection site, the so-called hypersensitive response...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807724/the-versatile-functions-of-lrr-only-proteins-in-mollusk-chlamys-farreri
#3
Mengqiang Wang, Lingling Wang, Zhihao Jia, Xiudan Wang, Qilin Yi, Zhao Lv, Linsheng Song
Leucine-rich repeat (LRR)-only proteins are involved in the innate immune responses as they mediate protein-ligand interactions. In the present study, three novel LRR-only proteins, CfLRRop-4, CfLRRop-5 and CfLRRop-6, were identified and characterized from Zhikong scallop Chlamys farreri. They all contained LRR motifs with consensus signature sequences of LxxLxLxxNxL or LxxLxLxxCxxL. All the mRNA transcripts of three CfLRRops were high abundant in hepatopancreas, gills and gonads, and their mRNA transcripts in hemocytes could respond to the stimulations of different microbes, including Vibrio anguillarum, Micrococcus luteus and Pichia pastoris...
August 11, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28807666/microrna-132-with-therapeutic-potential-in-chronic-wounds
#4
Xi Li, Dongqing Li, Aoxue Wang, Tongbin Chu, Warangkana Lohcharoenkal, Xiaowei Zheng, Jacob Grünler, Sampath Narayanan, Sofie Eliasson, Eva K Herter, Yang Wang, Yannan Ma, Marcus Ehrström, Liv Eidsmo, Maria Kasper, Andor Pivarcsi, Enikö Sonkoly, Sergiu-Bogdan Catrina, Mona Ståhle, Ning Xu Landén
Chronic wounds represent a major and rising health and economic burden worldwide. There is a continued search towards more effective wound therapy. We found significantly reduced microRNA-132 (miR-132) expression in human diabetic ulcers compared to normal skin wounds, and also in skin wounds of leptin receptor-deficient (db/db) diabetic mice compared to wild-type mice. Local replenishment of miR-132 in the wounds of db/db mice accelerated wound closure effectively, which was accompanied by increased proliferation of wound-edge keratinocytes and reduced inflammation...
August 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28803958/identification-and-characterization-of-lymph-organ-micrornas-in-red-swamp-crayfish-procambarus-clarkii-infected-with-white-spot-syndrome-virus
#5
Zhi-Qiang Du, Xiao-Yun Leng, Xiu-Li Shen, Yan-Hui Jin, Xin-Cang Li
MicroRNAs (miRNAs) were important post-transcriptional regulators and played vital roles in innate immunity system of invertebrates, especially in the aspect of antivirus. In this study, using high-throughput small RNAs Illumina sequencing system, differently expressed miRNAs (DEMs) from lymph organs in red swamp crayfish, Procambarus clarkii, infected with white spot syndrome virus, were identified. As a result, 32 known miRNAs and 7 novel miRNAs were identified in crayfish lymph organ small RNAs library of NG and WG...
August 10, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28801521/role-of-pattern-recognition-receptors-of-the-neurovascular-unit-in-inflamm-aging
#6
Imola Wilhelm, Ádám Nyúl-Tóth, Mihaly Kozma, Attila E Farkas, Istvan A Krizbai
Aging is associated with chronic inflammation (inflamm-aging) partly mediated by increased levels of damage-associated molecular patterns (DAMPs) which activate pattern recognition receptors (PRRs) of the innate immune system. Furthermore, many aging-related disorders are associated with inflammation. PRRs, like Toll-like receptors (TLRs) and NOD-like receptors (NLRs) are not only expressed in cells of the innate immune system, but other cells as well, including cells of the neurovascular unit (NVU) and cerebral vasculature forming the blood-brain barrier (BBB)...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28791669/strategies-for-preventing-peritoneal-fibrosis-in-peritoneal-dialysis-patients-new-insights-based-on-peritoneal-inflammation-and-angiogenesis
#7
REVIEW
Zhen Zhang, Na Jiang, Zhaohui Ni
Peritoneal dialysis (PD) is an established form of renal replacement therapy. Long-term PD leads to morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosis, a known cause of loss of peritoneal ultrafiltration capacity. Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis. This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammation and angiogenesis, including Toll-like receptor ligand-mediated, NOD-like receptor protein 3/interleukin-1β, vascular endothelial growth factor, and angiopoietin-2/Tie2 signaling pathways...
August 8, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28783736/glutamate-alleviates-muscle-protein-loss-by-modulating-tlr4-nods-akt-foxo-and-mtor-signaling-pathways-in-lps-challenged-piglets
#8
Ping Kang, Xiuying Wang, Huanting Wu, Huiling Zhu, Yongqing Hou, Longmei Wang, Yulan Liu
The experiment was conducted to study the effect of the glutamate (Glu) on muscle protein loss through toll-like receptor 4 (TLR4), nucleotide-binding oligomerization domain proteins (NODs), Akt/Forkhead Box O (Akt/FOXO) and mammalian target of rapamycin (mTOR) signaling pathways in LPS-challenged piglets. Twenty-four weaned piglets were assigned into four treatments: (1) Control; (2) LPS+0% Glu; (3) LPS + 1.0% Glu; (4) LPS + 2.0% Glu. The experiment was lasted for 28 days. On d 28, the piglets in the LPS challenged groups were injected with LPS on 100 μg/kg body weight (BW), and the piglets in the control group were injected with the same volume of 0...
2017: PloS One
https://www.readbyqxmd.com/read/28782622/banxia-houpu-decoction-restores-glucose-intolerance-in-cums-rats-through-improvement-of-insulin-signaling-and-suppression-of-nlrp3-inflammasome-activation-in-liver-and-brain
#9
Ke-Ke Jia, Yan-Jing Zheng, Yan-Xiu Zhang, Jia-Hui Liu, Rui-Qing Jiao, Ying Pan, Ling-Dong Kong
ETHNOPHARMACOLOGICAL RELEVANCE: Banxia-houpu decoction is a famous formula in traditional Chinese medicine (TCM) with the powerful anti-depressant activity. AIM OF THE STUDY: This study aimed to investigate the effect of Banxia-houpu decoction on glucose intolerance associated with anhedonia in chronic unpredictable mild stress (CUMS) rats, then to explore its underlying pharmacological mechanisms. MATERIALS AND METHODS: After 6-week CUMS procedure, male Wistar rats were given Banxia-houpu decoction (3...
August 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28780410/genome-wide-transcriptome-analysis-of-hippocampus-in-rats-indicated-that-tlr-nlr-signaling-pathway-was-involved-in-the-pathogenisis-of-depressive-disorder-induced-by-chronic-restraint-stress
#10
Yu Wang, Huili Jiang, Hong Meng, Jun Lu, Jing Li, Xuhui Zhang, Xinjing Yang, Bingcong Zhao, Yang Sun, Tuya Bao
Data from clinical investigations and laboratory fundings have provided preliminary evidence for the effectiveness and safety of acupuncture therapy in depression. However, the mechanisms underlying the antidepressant response of acupuncture are not fully elucidated. To elucidate the potential effects of acupuncture for depression on the hippocampal genome-wide transcriptome at the molecular level, we evaluated the transcriptomic profile of depression rats under treatment of acupuncture, and fluoxetine. We identified a very significant effect of acupucture intervention, with 107 genes differentially expressed in acupuncture vs...
August 2, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28776416/synthetic-agonists-of-nod-like-rig-i-like-and-c-type-lectin-receptors-for-probing-the-inflammatory-immune-response
#11
Amy E Nielsen, Joseph D Hantho, Rock J Mancini
Synthetic agonists of innate immune cells are of interest to immunologists due to their synthesis from well-defined materials, optimized activity, and monodisperse chemical purity. These molecules are used in both prophylactic and therapeutic contexts from vaccines to cancer immunotherapies. In this review we highlight synthetic agonists that activate innate immune cells through three classes of pattern recognition receptors: NOD-like receptors, RIG-I-like receptors, and C-type lectin receptors. We classify these agonists by the receptor they activate and present them from a chemical perspective, focusing on structural components that define agonist activity...
August 4, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28768269/a-potential-role-for-the-nod1-variant-rs6958571-in-gram-positive-blood-stream-infection-in-elbw-infants
#12
Venkatesh Sampath, Neil Mulrooney, Aloka L Patel, Jonathan Cohen, Liyun Zhang, Jeffery Garland, Pascal M Lavoie, John Dagle, Pippa Simpson
BACKGROUND: The genetic basis of sepsis susceptibility in preterm infants remains understudied. Herein, we investigated the nucleotide binding-oligomerization domain (NOD)-like receptor (NLR) family of immune receptors as putative loci for preterm sepsis susceptibility. OBJECTIVE: To determine whether single nucleotide polymorphisms (SNPs) in NLR genes are associated with blood stream infections (BSI) in premature infants. METHODS: An international cohort of infants with gestational age (GA) <35 weeks were genotyped for SNPs in the ATG16L1, CARD8, NLRP3, NOD2, and NOD1 genes...
August 3, 2017: Neonatology
https://www.readbyqxmd.com/read/28766178/differential-regulation-of-il-1%C3%AE-and-il-6-release-in-murine-macrophages
#13
Seishiro Hirano, Quan Zhou, Akiko Furuyama, Sanae Kanno
Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1β release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome. However, the conversion of pro-IL-1β to its active form seems to depend on the macrophage cell types. In the present study, bone marrow-derived macrophages (BMM) and three murine macrophage cell lines, J774.1, J774A.1, and RAW264.7 were exposed to ATP or fibrous titanium dioxide (FTiO2) in the presence or absence of lipopolysaccharide (LPS), and the concentrations of IL-1β and IL-6 in both cell lysates and in the culture media were measured by immunoblotting to differentiate active form of IL-1β from pro-IL-1β...
August 1, 2017: Inflammation
https://www.readbyqxmd.com/read/28752716/-progress-on-mechanisms-for-pathogensto-evade-nod-like-receptor-and-toll-like-receptor-signaling-pathways
#14
H E Yujie, Pan Jianping
The innate immune system provides a first line of defense against invading pathogens, in which the pattern recognition receptors (PRR) recognize pathogen-associated molecular patterns (PAMP) and initiate the downstream signaling pathways to eliminate the encountered pathogens. There are two main classes of such signaling pathways: NOD-like receptor (NLR) signaling pathway and Toll-like receptor (TLR) signaling pathway. The microbial pathogens under selective pressure have evolved numerous mechanisms to avoid and/or manipulate the NLR and TLR signal transduction for survival and replication...
March 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28752408/the-nlrp3-inflammasome-an-important-driver-of-neuroinflammation-in-hemorrhagic-stroke
#15
REVIEW
Shao-Jun Yang, Gao-Feng Shao, Jiang-Li Chen, Jie Gong
Hemorrhagic stroke is a devastating clinical event with no effective medical treatment. Neuroinflammation, which follows a hemorrhagic stroke, is an important element that involves both acute brain injury and subsequent brain rehabilitation. Therefore, delineating the key inflammatory mediators and deciphering their pathophysiological roles in hemorrhagic strokes is of great importance in the development of novel therapeutic targets for this disease. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that is localized within the cytoplasm...
July 27, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28741645/inflammasome-and-autophagy-regulation-a-two-way-street
#16
Qian Sun, Jie Fan, Timothy R Billiar, Melanie J Scott
Inflammation plays a significant role in protecting hosts against pathogens. Inflammation induced by non-infectious, endogenous agents can be detrimental, and if excessive can result in organ and tissue damage. The inflammasome is a major innate immune pathway that can be activated via both exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs). Inflammasome activation involves formation and oligomerization of a protein complex including a NOD-like receptor (NLR), an adaptor protein (ASC) and procaspase-1...
July 24, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28740491/nod-like-receptor-p3-inflammasome-controls-protective-th1-th17-immunity-against-pulmonary-paracoccidioidomycosis
#17
Claudia Feriotti, Eliseu Frank de Araújo, Flavio Vieira Loures, Tania Alves da Costa, Nayane Alves de Lima Galdino, Dario Simões Zamboni, Vera Lucia Garcia Calich
The NOD-like receptor P3 (NLRP3) inflammasome is an intracellular multimeric complex that triggers the activation of inflammatory caspases and the maturation of IL-1β and IL-18, important cytokines for the innate immune response against pathogens. The functional NLRP3 inflammasome complex consists of NLRP3, the adaptor protein apoptosis-associated speck-like protein, and caspase-1. Various molecular mechanisms were associated with NLRP3 activation including the presence of extracellular ATP, recognized by the cell surface P2X7 receptor (P2X7R)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28740490/inhibition-of-the-nod-like-receptor-protein-3-inflammasome-is-protective-in-juvenile-influenza-a-virus-infection
#18
Bria M Coates, Kelly L Staricha, Nandini Ravindran, Clarissa M Koch, Yuan Cheng, Jennifer M Davis, Dale K Shumaker, Karen M Ridge
Influenza A virus (IAV) is a significant cause of life-threatening lower respiratory tract infections in children. Antiviral therapy is the mainstay of treatment, but its effectiveness in this age group has been questioned. In addition, damage inflicted on the lungs by the immune response to the virus may be as important to the development of severe lung injury during IAV infection as the cytotoxic effects of the virus itself. A crucial step in the immune response to IAV is activation of the NOD-like receptor protein 3 (NLRP3) inflammasome and the subsequent secretion of the inflammatory cytokines, interleukin-1β (IL-1β), and interleukin-18 (IL-18)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28740332/a-protective-role-of-glibenclamide-in-inflammation-associated-injury
#19
REVIEW
Gensheng Zhang, Xiuhui Lin, Shufang Zhang, Huiqing Xiu, Chuli Pan, Wei Cui
Glibenclamide is the most widely used sulfonylurea drug for the treatment of type 2 diabetes mellitus (DM). Recent studies have suggested that glibenclamide reduced adverse neuroinflammation and improved behavioral outcomes following central nervous system (CNS) injury. We reviewed glibenclamide's anti-inflammatory effects: abundant evidences have shown that glibenclamide exerted an anti-inflammatory effect in respiratory, digestive, urological, cardiological, and CNS diseases, as well as in ischemia-reperfusion injury...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28739827/transcriptional-profiling-of-the-chicken-tracheal-response-to-virulent-mycoplasma-gallisepticum-strain-rlow
#20
J Beaudet, E R Tulman, K Pflaum, X Liao, G F Kutish, S M Szczepanek, L K Silbart, S J Geary
Mycoplasma gallisepticum, the primary etiologic agent of Chronic Respiratory Disease (CRD) in poultry, leads to prolonged recruitment and activation of inflammatory cells in the respiratory mucosa. This is consistent with the current model of immune dysregulation that ostensibly allows the organism to evade clearance mechanisms and establish chronic infection. To date, studies using qRT-PCR and microarrays have shown a significant transient up-regulation of cytokines and chemokines from tracheal epithelial cells (TECs) in vitro and tracheal tissue ex vivo in response to virulent strain Rlow, that contributes to the infiltration of inflammatory cells into the tracheal mucosa...
July 24, 2017: Infection and Immunity
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