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https://www.readbyqxmd.com/read/28441787/codon-usage-optimization-and-construction-of-plasmid-encoding-iranian-human-papillomavirus-type-16-e7-oncogene-for-lactococcus-lactis-subsp-cremoris-mg1363
#1
Amir Hossein Mohseni, Vadood Razavilar, Hossein Keyvani, Mohammad Reza Razavi, Ramazan Ali Khavari Nejad
HPV 16 intratypic sequence variations has been recognized in association with oncogenic potential diverge and geographic distribution. This study aimed to investigate nucleotide modifications and optimization of HPV 16 E7 regions from Iranian infected women. Cervical biopsies from 79/163 HPV 16 positive cancer patients detected in our study were analyzed by PCR in a couple of cloning of a complete ORF of the E7 gene, and sequencing. The most frequently observed variant was C196T in E7 which led to an amino acid change of R66W...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28441781/dengue-virus-non-structural-protein-5
#2
REVIEW
Abbas El Sahili, Julien Lescar
The World Health Organization estimates that the yearly number of dengue cases averages 390 million. This mosquito-borne virus disease is endemic in over 100 countries and will probably continue spreading, given the observed trend in global warming. So far, there is no antiviral drug available against dengue, but a vaccine has been recently marketed. Dengue virus also serves as a prototype for the study of other pathogenic flaviviruses that are emerging, like West Nile virus and Zika virus. Upon viral entry into the host cell and fusion of the viral lipid membrane with the endosomal membrane, the viral RNA is released and expressed as a polyprotein, that is then matured into three structural and seven non-structural (NS) proteins...
April 24, 2017: Viruses
https://www.readbyqxmd.com/read/28441513/antibody-persistence-following-meningococcal-c-conjugate-vaccination-in-children-and-adolescents-infected-with-human-immunodeficiency-virus
#3
Ana Cristina Cisne Frota, Lee H Harrison, Bianca Ferreira, Daniela Menna-Barreto, Raquel Bernardo Nana de Castro, Giselle Pereira da Silva, Ricardo Hugo de Oliveira, Thalita F Abreu, Lucimar G Milagres, Cristina B Hofer
OBJECTIVE: HIV-infected individuals (HIVI) are threatened by meningococcal infection and presented lower response to vaccines. Data are scarce on long-term persistence of human serum bactericidal antibody (hSBA) after a meningococcal C conjugate (MCC) vaccine in HIVI youth; the authors aimed to describe this persistence in HIVI. METHODS: HIVI and HIV uninfected individuals (HIVU), aged 2-18 years, CD4 >15% were recruited. Seroprotection (hSBA ≥1:4) at baseline and at 12-18 months after immunization was evaluated and the association of the different factors with the long-term persistence was calculated using logistic regression...
April 22, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28441361/immunization-strategies-targeting-newly-arrived-migrants-in-non-eu-countries-of-the-mediterranean-basin-and-black-sea
#4
Cristina Giambi, Martina Del Manso, Maria Grazia Dente, Christian Napoli, Carmen Montaño-Remacha, Flavia Riccardo, Silvia Declich, Network For The Control Of Cross-Border Health Threats In The Mediterranean Basin And Black Sea For The ProVacMed Project
Background: The World Health Organization recommends that host countries ensure appropriate vaccinations to refugees, asylum seekers and migrants. However, information on vaccination strategies targeting migrants in host countries is limited. Methods: In 2015-2016 we carried out a survey among national experts from governmental bodies of 15 non-EU countries of the Mediterranean and Black Sea in order to document and share national vaccination strategies targeting newly arrived migrants. Results: Four countries reported having regulations/procedures supporting the immunization of migrants at national level, one at sub-national level and three only targeting specific population groups...
April 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28441266/safety-of-the-inactivated-japanese-encephalitis-virus-vaccine-ixiaro%C3%A2-in-children-an-open-label-randomized-active-controlled-phase-3-study
#5
Katrin L Dubischar, Vera Kadlecek, Benjamin Sablan, Charissa Fay Borja-Tabora, Salvacion Gatchalian, Susanne Eder-Lingelbach, Zsuzsanna Mueller, Kerstin Westritschnig
BACKGROUND: Japanese encephalitis (JE) remains a serious health concern in Asian countries and has sporadically affected pediatric travelers. In the present study we monitored the safety profile of the JE virus (JEV) vaccine IXIARO in a pediatric population. METHODS: We randomized 1869 children between the age of 2 months and 17 years in an age-stratified manner to vaccination with IXIARO or one of the control vaccines, Prevnar and HAVRIX 720. Adverse events (AEs) (unsolicited and solicited local and systemic adverse events), serious AEs and medically-attended AEs were assessed up to Day 56 and Month 7 after the first dose...
April 24, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28441109/meningococcal-serogroup-b-vaccine-knowledge-and-acceptability-among-parents-in-italy
#6
Teresa Morrone, Francesco Napolitano, Luciana Albano, Gabriella Di Giuseppe
This study aimed to evaluate the knowledge and attitudes about Meningococcal meningitis B and the relative vaccine for children among a sample of parents in Italy. A cross-sectional investigation was conducted from October to December 2015 among a sample of 910 parents in the geographic area of Naples and Salerno (Italy). In total, 543 of 910 parents returned a completed questionnaire for a response rate of 59.7%. Almost all parents had heard about meningitis (95.8%), 79.8% of these knew the mode of transmission (through respiratory droplets) and 62...
April 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28441105/transcriptomic-dissection-of-the-horizontally-acquired-response-regulator-esrb-reveals-its-global-regulatory-roles-in-the-physiological-adaptation-and-activation-of-t3ss-and-the-cognate-effector-repertoire-in-edwardsiella-piscicida-during-infection-towards
#7
Yang Liu, Luyao Zhao, Minjun Yang, Kaiyu Yin, Xiaohui Zhou, Ka Yin Leung, Qin Liu, Yuanxing Zhang, Qiyao Wang
Edwardsiella piscicida is the leading pathogen threatening worldwide aquaculture industries. The two-component system (TCS) EsrA-EsrB is essential for the pathogenesis of this bacterium. However, little is known about the regulon and regulatory mechanism of EsrA-EsrB or about the factors that mediate the interaction of TCS with bacterial hosts. Here, our RNA-seq analysis indicated that EsrB strongly induces type III and type VI secretion systems (T3/T6SS) expression and that it modulates the expression of both physiology- and virulence-associated genes in E...
April 25, 2017: Virulence
https://www.readbyqxmd.com/read/28441094/background-rates-of-disease-in-latin-american-children-from-a-rotavirus-vaccine-study
#8
Marc Baay, Kaatje Bollaerts, Claudio Struchiner, Thomas Verstraeten
BACKGROUND: Knowledge of background rates of adverse events is crucial to assess vaccine safety concerns. We used data from a rotavirus vaccine study (Ruiz-Palacios et al., NEJM, 2006) including 63,225 infants from 11 Latin American countries to investigate reporting rates of serious adverse events (SAEs) among these infants, and describe rates by country, gender, age, and season. METHODS: For this randomized, double-blind, placebo-controlled, phase 3 trial, investigators from Argentina, Brazil, Chile, Colombia, Dominican Republic, Honduras, Mexico, Nicaragua, Panama, Peru, and Venezuela recruited 6-to-13-week-old healthy infants...
April 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28441089/one-size-fits-all-antibody-avidity-measurement-against-multiple-antigens-in-maternal-vaccination-studies
#9
Thomas Rice, Beate Kampmann, Beth Holder
No abstract text is available yet for this article.
April 25, 2017: Virulence
https://www.readbyqxmd.com/read/28441062/measles-cases-among-adolescents-in-southern-pakistan-2012-2015-the-case-for-revisiting-vaccination-strategies
#10
Sadia Shakoor, Erum Khan, Muhammad Imran Rajput, Wali Muhammad Rahimoon
AIMS: Surveillance of adult measles in Pakistan is a challenge as it does not enjoy the status of a reportable disease unlike childhood cases and therefore cases remain undetected and unreported or misdiagnosed. Consequently no data or estimates of young adult cases, seroprevalence, or estimates of susceptible preadolescent or young adult population exist. We have presented both laboratory conformed and clinically suspected cases of measles occurring in adolescents and adults in the southern province of Sindh in Pakistan...
April 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28440992/-autoimmune-inflammatory-syndrome-induced-by-adjuvants-a-new-clinical-entity
#11
Belkis Ferrer-Cosme, Damiana Téllez-Martínez, Alexander Batista-Duharte
Recently Shoenfeld and Agmon-Levin proposed a new clinical entity called autoimmune/inflammatory syndrome induced by adjuvants (ASIA), which includes four clinical entities called: 1) siliconosis, 2) Gulf War syndrome, 3) macrophage myofasciitis) and 4) post-vaccination phenomenon associated with adjuvants. They all have a common denominator: a prior exposure to immunoadjuvants, and, in addition, they also share several clinical criteria associated to chronic inflammation and autoimmune reactions. This proposal still needs to be validated by the scientific community, but nowadays is a topic of hot discussion in the literature and in various international conferences...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28440879/tick-borne-encephalitis-in-patients-vaccinated-against-this-disease
#12
S Lotrič-Furlan, P Bogovič, T Avšič-Županc, M Jelovšek, L Lusa, F Strle
BACKGROUND: Information on tick-borne encephalitis (TBE) in patients already vaccinated against the disease is limited. OBJECTIVES: To compare the course and outcome in patients with vaccination breakthrough TBE with findings in patients who developed TBE without previous vaccination. METHODS: All adult patients diagnosed with TBE at a single medical centre during a 16-year period and who had received at least two doses of TBE vaccine before the onset of illness qualified for the study...
April 25, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28440878/an-alert-to-latin-america-current-human-papillomavirus-vaccination-trends-highlight-key-barriers-to-successful-implementation
#13
Angelica Nogueira-Rodrigues, Alexandra Bukowski, Eduardo Paulino, Jessica St Louis, Adriana Barrichello, Cinthya Sternberg, Markus A C Gifoni, Silvana Luciani, Paul E Goss
No abstract text is available yet for this article.
April 25, 2017: Cancer
https://www.readbyqxmd.com/read/28440707/recent-developments-in-nanocarrier-aided-mucosal-vaccination
#14
Olga Kammona, Vassilis Bourganis, Theodora Karamanidou, Costas Kiparissides
To date, most of the licensed vaccines for mucosal delivery are based on live-attenuated viruses which carry the risk of regaining their pathogenicity. Therefore, the development of efficient nonviral vectors allowing the induction of potent humoral and cell-mediated immunity is regarded as an imperative scientific challenge as well as a commercial breakthrough for the pharma industries. For a successful translation to the clinic, such nanocarriers should protect the antigens from mucosal enzymes, facilitate antigen uptake by microfold cells and allow the copresentation of robust, safe for human use, mucosal adjuvants to antigen-presenting cells...
April 25, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28440668/tweeting-influenza-vaccine-to-cardiovascular-health-community
#15
Chayakrit Krittanawong, Anusith Tunhasiriwet, Sakkarin Chirapongsathorn, Takeshi Kitai
Globally, among infectious diseases, influenza is one of the leading causes of morbidity and mortality. Individuals with chronic conditions, including cardiovascular disease and diabetes, are particularly vulnerable to complications of an influenza infection. The European Society of Cardiology recommended annual influenza vaccinations for patients with cardiovascular disease. Numerous studies have suggested a link between influenza and increased risk of cardiovascular events. Despite its proven benefits, little is known about the reason for the underutilization of influenza vaccination...
April 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28440642/asymmetric-silica-nanoparticles-with-tunable-head-tail-structures-enhance-hemocompatibility-and-maturation-of-immune-cells
#16
Prasanna Lakshmi Abbaraju, Anand Kumar Meka, Hao Song, Yannan Yang, Manasi Jambhrunkar, Jun Zhang, Chun Xu, Meihua Yu, Chengzhong Yu
Asymmetric mesoporous silica nanoparticles (MSN) with controllable head-tail structures have been successfully synthesized. The head particle type is tunable (solid or porous) and the tail has dendritic large pores. The tail length and tail coverage on head particles are adjustable. Compared to spherical silica nanoparticles with a solid structure (Stöber spheres) or large-pore symmetrical MSN with fully covered tails, asymmetrical head-tail MSN (HTMSN) show superior hemocompatibility due to reduced membrane deformation of red blood cells and decreased level of reactive oxygen species...
April 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28440596/immunogenicity-of-a-fully-synthetic-muc1-glycopeptide-antitumor-vaccine-enhanced-by-poly-i-c-as-tlr3-activating-adjuvant
#17
Horst Kunz, Markus Glaffig, Natascha Stergiou, Edgar Schmitt
Fully synthetic MUC1 glycopeptide antitumor vaccines have an exactly specified structure, and induce a targeted immune response without suppression of the immune response when using an immunogenic carrier protein. However, tumor-associated aberrantly glycosylated MUC1 glycopeptides are endogenous structures, "self-antigens", which exhibit only low immunogenicity. To overcome this obstacle, a fully synthetic MUC1 glycopeptide antitumor vaccine 1 was combined with polyinosinic:polycytidylic acid, poly(I:C), as a structurally defined Toll-like receptor 3 activating adjuvant...
April 25, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28440187/genetic-modifications-of-icosahedral-plant-virus-based-nanoparticles-for-vaccine-and-immunotherapy-applications
#18
Kannan Badri Narayanan, Sung Soo Han
Vaccine development is one of the greatest achievements of modern medicine. Vaccines made of live-attenuated pathogens can revert to virulent live strains, which causes safety concerns. On the other hand, the use of purified antigenic components as subunit vaccines is safer, but less effective, as these components induce lower levels of protective immunity. Multiple copy presentation of an antigenic determinant in a well-ordered and well-defined orientation on a nanosized particle can mimic the natural host-pathogen surface interaction to provide antigen stability and immunogenicity similar to that of conventional vaccines with improved safety...
April 24, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28439753/abating-mercury-exposure-in-young-children-should-include-thimerosal-free-vaccines
#19
REVIEW
José G Dórea
Pediatric immunization is essential to prevent, control and eradicate children`s infectious diseases. Newborns and infants in less developed countries have a concentrated schedule of Thimerosal-containing vaccines (TCVs); pregnant mothers are also immunized with TCVs. Metabolic changes during early development are demonstrably an important risk factor for ethylmercury (EtHg) effects on neurodevelopment, while exposure to Thimerosal sensitizes susceptible individuals to life-long contact dermatitis. Concerns regarding toxicity of Hg have moved rich nations to withdraw it from medicines and, in particular, Thimerosal from pediatric vaccines; it has been more than 20 years since rich countries started using Thimerosal-free vaccines...
April 24, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28439708/hepatitis-b-virus-infection-assessed-3-to-18%C3%A2-years-after-vaccination-in-cuban-children-and-adolescents-born-to-hbsag-positive-mothers
#20
Licel de Los Angeles Rodríguez Lay, Marité Bello Corredor, Maria Caridad Montalvo Villalba, Annia Gertrudis Chibás Ojeda, Susel Sariego Frómeta, Manuel Diaz González, Yoandra Abad Lamoth, Meilin Sánchez Wong, Aurélie Sausy, Claude P Muller, Judith M Hübschen
Thirty-two participants, aged between 3-18 years, born to hepatitis B surface antigen (HBsAg)-positive mothers and vaccinated at birth were analyzed for hepatitis B virus (HBV) infection. Overall, 56% had anti-HB titers ≥10 IU/L; five were positive for antibodies to the core antigen (anti-HBc), and two of these were also positive for HBsAg/DNA. One of the HBsAg/anti-HBc double-negative children presented with an unusual occult infection (HBV DNA-positive). No known vaccine escape mutations were detectable...
April 24, 2017: Archives of Virology
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