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statin in acute coronary syndrome

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https://www.readbyqxmd.com/read/28917689/effect-of-early-pitavastatin-therapy-on-coronary-fibrous-cap-thickness-assessed-by-optical-coherence-tomography-in-patients-with-acute-coronary-syndrome-the-escort-study
#1
Tsuyoshi Nishiguchi, Takashi Kubo, Takashi Tanimoto, Yasushi Ino, Yoshiki Matsuo, Takashi Yamano, Kosei Terada, Hiroki Emori, Yosuke Katayama, Akira Taruya, Yuichi Ozaki, Yasutsugu Shiono, Kunihiro Shimamura, Takeyoshi Kameyama, Hironori Kitabata, Tomoyuki Yamaguchi, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
OBJECTIVES: The aim of the present study was to assess the effect of early statin therapy on fibrous-cap thickness in coronary plaques of patients with acute coronary syndrome (ACS) by using optical coherence tomography. BACKGROUND: Statins can contribute to the stabilization of coronary plaques. METHODS: This is a prospective, randomized, active-controlled, single-center study. Patients with ACS and untreated dyslipidemia were enrolled and randomly allocated (ratio 1:1) to either the early statin group (received pitavastatin 4 mg/day from baseline) or the late statin group (received pitavastatin 4 mg/day from 3 weeks after the baseline)...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28916255/impact-of-nonfasting-triglycerides-high-density-lipoprotein-cholesterol-ratio-on-secondary-prevention-in-patients-treated-with-statins
#2
Ichiro Matsumoto, Atsushi Misaki, Mizuki Kurozumi, Tsunetatsu Nanba, Yuichiro Takagi
BACKGROUND: Some studies have demonstrated that low-density lipoprotein cholesterol (LDL-C) lowering therapy is one of the most important strategies to prevent coronary artery disease. Also, serum triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) are recognized as independent risk factors of cardiovascular diseases. The aim of this study was to investigate whether the nonfasting TG/HDL-C ratio could affect the incidence of cardiovascular events after percutaneous coronary intervention (PCI) even in patients treated with statins...
September 12, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28902639/the-role-of-specialized-prevention-clinics-for-the-short-term-follow-up-of-acute-coronary-syndromes
#3
Salih Kılıç, Evrim Şimşek, Hatice Soner Kemal, Elif İlkay Yüce, Cüneyt Türkoğlu, Meral Kayıkçıoğlu
OBJECTIVE: This study aimed to investigate the effect of specialized prevention clinics and standard clinics follow-ups on secondary protection after acute coronary syndrome (ACS) on cardiovascular risk factors. METHODS: A total of 118 patients who received thrombolytic therapy after being diagnosed with ST-segment elevation myocardial infarction were followed up for 6 months. After ACS, patients in a specialized prevention clinic (Group 1) (n=67) and those in a standard clinic (Group 2) (n=51) were compared in terms of the change in their lifestyle, management of risk factors, and drug compliance...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28886926/2017-focused-update-of-the-2016%C3%A2-acc%C3%A2-expert-consensus-decision-pathway-on-the-role-of-non-statin-therapies-for-ldl-cholesterol-lowering-in%C3%A2-the-management-of-atherosclerotic-cardiovascular-disease-risk-a-report-of-the-american-college-of-cardiology-task-force
#4
Donald M Lloyd-Jones, Pamela B Morris, Christie M Ballantyne, Kim K Birtcher, David D Daly, Sondra M DePalma, Margo B Minissian, Carl E Orringer, Sidney C Smith
In 2016, the American College of Cardiology published the first expert consensus decision pathway (ECDP) on the role of non-statin therapies for low-density lipoprotein (LDL)-cholesterol lowering in the management of atherosclerotic cardiovascular disease (ASCVD) risk. Since the publication of that document, additional evidence and perspectives have emerged from randomized clinical trials and other sources, particularly considering the longer-term efficacy and safety of proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors in secondary prevention of ASCVD...
August 30, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28882733/-risk-of-fatal-non-fatal-events-in-patients-with-previous-coronary-heart-disease-acute-myocardial-infarction-and-treatment-with-non-steroidal-anti-inflammatory-drugs
#5
REVIEW
L Muñoz Olmo, J Juan Armas, J J Gomariz García
BACKGROUND: Primary Care is the fundamental axis of our health system and obliges us to be consistent with our prescriptions. The non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with increased cardiovascular risk and increased risk of all causes of death, as well as acute myocardial infarction (AMI) in patients with a previous myocardial infarction. Pain and cardiac patient management are 2 basic pillars in our daily activity, and we must know the limitations of NSAIDs in patients with established cardiovascular risk...
September 4, 2017: Semergen
https://www.readbyqxmd.com/read/28881268/high-density-lipoprotein-cholesterol-associated-with-change-in-coronary-plaque-lipid-burden-assessed-by-near-infrared-spectroscopy
#6
Satoshi Honda, Samuel L Sidharta, Daisuke Shishikura, Kohei Takata, Giuseppe A Di Giovanni, Tracy Nguyen, Alex Janssan, Susan W Kim, Jordan Andrews, Peter J Psaltis, Matthew I Worthley, Stephen J Nicholls
BACKGROUND AND AIMS: Little is known about the relation between serum lipid parameters and serial change in plaque composition using in vivo coronary imaging. The aim of this study was to examine the association between serum lipids and change in coronary plaque lipid burden assessed by near-infrared spectroscopy (NIRS). METHODS: We performed serial NIRS-intravascular ultrasound studies in 49 patients who underwent coronary angiography for an acute coronary syndrome (ACS) or stable ischemic symptoms...
August 31, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28875506/medications-recommended-for-secondary-prevention-after-first-acute-coronary-syndrome-effectiveness-of-treatment-combinations-in-real-life-setting
#7
Julien Bezin, Olaf H Klungel, Régis Lassalle, Caroline Dureau-Pournin, Nicholas Moore, Antoine Pariente
Long-term effectiveness of Evidence-Based Cardiovascular Medications (EBCMs) indicated after Acute Coronary Syndrome (ACS) needs to be assessed considering the combination effects for these drugs recommended in association. Using a nationwide database, we conducted a cohort study to evaluate the effectiveness of all possible incomplete EBCMs-based combinations as compared to that associating the four recommended EBCMs over up to five years of follow-up. Among the 31,668 patients included, 22.9% had ACS recurrence or died during follow-up...
September 5, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28867006/anti-inflammatory-treatment-and-risk-of-depression-in-91-842-patients-with-acute-coronary-syndrome-and-91-860-individuals-without-acute-coronary-syndrome-in-denmark
#8
Ida Kim Wium-Andersen, Marie Kim Wium-Andersen, Martin Balslev Jørgensen, Merete Osler
BACKGROUND: We examined if treatment with acetylsalicylic acid (ASA), non-steroid anti-inflammatory drugs (NSAID), or statins after acute coronary syndrome (ACS) are associated with decreased risk of depression. METHOD: This register-based cohort study included all individuals with a first-time hospital admissions with an ACS diagnosis registered between January 2001 to December 2009 (N=91,842) and a comparable reference population without ACS (N=91,860). Information of ASA, NSAID, and statin use were retrieved from a national prescription register...
November 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28865748/circulating-pcsk9-levels-in-acute-coronary-syndrome-results-from-the-pc-sca-9-prospective-study
#9
B Cariou, P Guérin, C Le May, V Letocart, L Arnaud, B Guyomarch, M Pichelin, V Probst
BACKGROUND: Serum proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations have been shown to be positively associated with LDL cholesterol (LDL-C), but the relationship between PCSK9 and coronary atherosclerosis lesions remains unclear. OBJECTIVE: This study aims to investigate the correlation between serum PCSK9 levels and coronary damage severity in patients hospitalized for acute coronary syndrome (ACS). METHODS: In this prospective proof-of-concept study, coronary lesions were assessed using SYNTAX scores...
August 30, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28863874/a-randomized-controlled-trial-of-eicosapentaenoic-acid-in-patients-with-coronary-heart-disease-on-statins
#10
Tetsu Watanabe, Kaoru Ando, Hyuma Daidoji, Yoichiro Otaki, Shigeo Sugawara, Motoyuki Matsui, Eiichiro Ikeno, Osamu Hirono, Hiroshi Miyawaki, Yoshinori Yashiro, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Tetsuro Shishido, Takehiko Miyashita, Takuya Miyamoto, Isao Kubota
BACKGROUND: There is a residual risk of coronary heart disease (CHD) despite intensive statin therapy for secondary prevention. The aim of this study was to investigate whether coronary plaque regression and stabilization are reinforced by the addition of eicosapentaenoic acid (EPA) to high-dose pitavastatin (PTV). METHODS: We enrolled 193 CHD patients who underwent percutaneous coronary intervention (PCI) in six hospitals. Patients were randomly allocated to the PTV group (PTV 4mg/day, n=96) or PTV/EPA group (PTV 4mg/day and EPA 1800mg/day, n=97), and prospectively followed for 6-8 months...
August 29, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28859658/the-effect-of-socioeconomic-disadvantage-on-prescription-of-guideline-recommended-medications-for-patients-with-acute-coronary-syndrome-systematic-review-and-meta-analysis
#11
REVIEW
Karice K Hyun, David Brieger, Mark Woodward, Sarah Richtering, Julie Redfern
BACKGROUND: There are varying data on whether socioeconomic status (SES) affects the treatment in patients with acute coronary syndrome (ACS). Our aim was to obtain a reliable estimate of the effect of SES on discharge prescription of medications following an ACS through systematic review and meta-analysis. METHODS: Medline, EMBASE and Global Health were searched systematically on 6th April 2016. Studies were eligible if the participants had ACS and reported the rate/odds of guideline-recommended ACS medications prescription (aspirin, antiplatelet, beta blocker, angiotensin co-enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARB) and statin) at discharge stratified by SES...
August 31, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28855433/effects-of-cardiac-rehabilitation-on-high-density-lipoprotein-mediated-cholesterol-efflux-capacity-and-paraoxonase-1-activity-in-patients-with-acute-coronary-syndrome
#12
Fumiaki Furuyama, Shinji Koba, Yuya Yokota, Fumiyoshi Tsunoda, Makoto Shoji, Youichi Kobayashi
AIMS: We evaluated whether exercised-based cardiac rehabilitation (CR) can ameliorate the HDL function, i.e., cholesterol efflux capacity (CEC) and paraoxonase-1 activity in patients with acute coronary syndrome (ACS). METHODS: This study is a retrospective analysis of stored serum from patients with ACS following successful percutaneous coronary intervention. The CEC, measured by a cell-based ex vivo assay using apolipoprotein B-depleted serum and (3)H-cholesterol labeled macrophages and arylesterase activity (AREA) at the onset or early phase of ACS, and the follow-up periods were compared between 69 patients who completed the five-month outpatient CR program (CR group) and 15 patients who did not participate and/or dropped out from CR program (non-CR group)...
August 30, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28840456/effects-of-statin-therapy-on-platelet-reactivity-after-percutaneous-coronary-revascularization-in-patients-with-acute-coronary-syndrome
#13
Anna Toso, Stefano De Servi, Mario Leoncini, Dominick J Angiolillo, Paolo Calabrò, Federico Piscione, Marco Cattaneo, Diego Maffeo, Antonio Bartorelli, Cataldo Palmieri, Marco De Carlo, Davide Capodanno, Philippe Genereux, Francesco Bellandi, Chiara Barozzi, Luciana Tomasi, Diego Della Riva, Tullio Palmerini
Statin use is associated with enhanced pharmacodynamic response to clopidogrel in patients with stable coronary artery disease undergoing percutaneous coronary intervention (PCI). However, the impact of statin therapy on clopidogrel response profiles in patients with acute coronary syndrome (ACS) undergoing PCI has not been established and represents the objective of this investigation. On-treatment P2Y12 platelet reactivity was measured using the vasodilator stimulated phosphoprotein (VASP) phosphorylation assay before PCI, at hospital discharge, and at 1 month after PCI in ACS patients enrolled in the multicenter, prospective GEne polymorphisms, Platelet Reactivity, and Syntax Score (GEPRESS) study (n = 962)...
August 24, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28822510/high-versus-low-dose-statin-therapy-in-indian-patients-with-acute-st-segment-elevation-myocardial-infarction-undergoing-thrombolysis
#14
K Priti, Anand Agrawal, Bhanwar L Ranwa
OBJECTIVES: This study sought to compare high dose versus low dose statin therapy in Indian patients with ST-segment elevation myocardial infarction (STEMI) undergoing thrombolysis. BACKGROUND: Randomized trials have demonstrated that statin treatment reduced major adverse cardiac events (MACEs) in patients with stable angina pectoris and acute coronary syndrome. However, randomized studies of statin therapy in Indian patients with STEMI are scarce. METHODS: Of 1859 patients with acute STEMI, 1027 eligible patients were randomized to 80-mg (n=512) or 10-mg (n=515) atorvastatin...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28814233/statins-in-acute-coronary-syndromes
#15
Manolis Vavuranakis, Maria Kariori, Gerasimos Siasos, Konstantinos Kalogeras, Dimitris Tousoulis
BACKGROUND: Patients with acute coronary syndrome (ACS) frequently experience recurrent adverse events from the cardiovascular system comparing to either healthy individuals or individuals with stable coronary artery disease. This is attributed to the inflammatory cascade that is activated during ACS resulting in increased risk for rupture of vulnerable plaques. OBJECTIVE: Therefore, it is of great importance to avoid recurrent events with treatment aiming at secondary prevention which includes the management of lipid profile besides alteration in the lifestyle and habits...
August 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28812321/prognostic-impact-of-intensive-statin-therapy-on-n-terminal-pro-bnp-level-in-non-st-segment-elevation-acute-myocardial-infarction-patients
#16
Mohamed Shehata, Ayman Samir, May Dardiri
OBJECTIVE: This study explored the impact of intensive daily dosing of atorvastatin on in-hospital N-terminal pro-B-type natriuretic peptide level, left ventricular systolic function and incidence of major adverse cardiac events in non-ST-segment elevation myocardial infarction patients. BACKGROUND: Several studies showed that early initiation of statin therapy in acute coronary syndrome patients has a favorable prognostic impact. METHODS: Hundred statin naive patients were prospectively enrolled...
August 15, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28810873/six-month-adherence-to-statin-use-and-subsequent-risk-of-major-adverse-cardiovascular-events-mace-in-patients-discharged-with-acute-coronary-syndromes
#17
Gaoqiang Xie, Yihong Sun, Phyo Kyaw Myint, Anushka Patel, Xingzi Yang, Min Li, Xian Li, Tao Wu, Shenshen Li, Runlin Gao, Yangfeng Wu
BACKGROUND: The evidence of adherence to statin decreasing risk of major adverse cardiovascular events (MACEs) is still lack among patients discharged with acute coronary syndrome (ACS). Our objective is to determine the relationship between six-month adherence to statins and subsequent risk of MACEs in patients discharged with ACS. METHODS: Using two prospective registry cohorts (CPACS-1 and -2), we analyzed data from 12,516 consecutive patients with ACS who were prescribed statin at hospital discharge and survived beyond 6 months without recurrent myocardial infarction (MI) or stroke...
August 15, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28796030/the-renoprotective-effects-of-simvastatin-and-atorvastatin-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention-an-observational-study
#18
Huan Ma, Yong Liu, Haixia Xie, Guolin Zhang, Huimin Zhan, Zhi Liu, Ping Wang, Qingshan Geng, Lan Guo
Some statins, such as atorvastatin, have proven renoprotective effects. The comparative renoprotective potential of simvastatin is less clear. This study aimed to compare the renoprotective effects of simvastatin with atorvastatin in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). This observational study examined the medical records of 271 patients who were treated at the Guangdong Cardiovascular Institute from April 2004 to February 2008. Patients had received either 40 mg simvastatin (n = 128) or 20 mg atorvastatin (n = 143), daily, for a period of at least 6 months following PCI...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28792164/survey-of-assessment-and-management-of-coronary-heart-disease-patients-smart-in-india
#19
Amit Singh, Vikram Singh, Rupesh Ranjan
OBJECTIVE: Survey of Assessment and MAnagement of CoRonary Heart Disease PaTients was undertaken to describe profile and management pattern of adult Acute Coronary Syndrome (ACS) patients from presentation till discharge, in private tertiary care Indian hospitals. MATERIALS AND METHODS: This was an observational, prospective study. Based on standard criteria, patients were diagnosed to have ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI) or unstable angina (UA)...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28761680/nurse-coordinated-care-improves-the-achievement-of-ldl-cholesterol-targets-through-more-intensive-medication-titration
#20
Marjolein Snaterse, Harald T Jorstad, Marlies Heiligenberg, Gerben Ter Riet, S Matthijs Boekholdt, Wilma Scholte Op Reimer, Ron J Peters
BACKGROUND: Nurse-coordinated care (NCC) improves the achievement of low-density lipoprotein-cholesterol (LDL-C) targets after an acute coronary syndrome (ACS). We hypothesised that NCC improves achievement of LDL-C targets through more intensive medication titration. METHODS: We used data from Randomised Evaluation of Secondary Prevention by Outpatient Nurse Specialists (RESPONSE), a multicentre randomised trial on the efficacy of NCC in 754 ACS patients. Follow-up data were collected at 6 and 12 months...
2017: Open Heart
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