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https://www.readbyqxmd.com/read/28916632/tissue-sex-and-age-specific-dna-methylation-of-rat-glucocorticoid-receptor-gene-promoter-and-insulin-like-growth-factor-2-imprinting-control-region
#1
Ogechukwu Brenda Agba, Ludwig Lausser, Klaus Huse, Christoph Bergmeier, Niels Jahn, Marco Groth, Martin Bens, Arne Sahm, Maria Gall, Otto W Witte, Hans A Kestler, Matthias Schwab, Matthias Platzer
Tissue-, sex- and age-specific epigenetic modifications such as DNA methylation are largely unknown. Changes in DNA methylation of the glucocorticoid receptor gene (NR3C1) and imprinting control region (ICR) of IGF2 and H19 genes during the lifespan are particularly interesting since these genes are susceptible to epigenetic modifications by prenatal stress or malnutrition. They are important regulators of development and aging. Methylation changes of NR3C1 affect glucocorticoid receptor expression, which is associated with stress sensitivity and stress-related diseases predominantly occurring during aging...
September 15, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28914367/no-association-of-single-nucleotide-polymorphisms-within-h19-and-hox-transcript-antisense-rna-hotair-with-genetic-susceptibility-to-systemic-lupus-erythematosus-rheumatoid-arthritis-and-primary-sj%C3%A3-gren-s-syndrome-in-a-chinese-han-population
#2
An-Fang Huang, Lin-Chong Su, Hong Jia, Yi Liu, Wang-Dong Xu
The H19 (rs2839698, rs3741219) and HOTAIR (rs920778) polymorphisms were related to many kinds of cancers. However, these polymorphisms have been scarcely explored in different autoimmune diseases. Here, we aimed to examine the association of the polymorphisms with susceptibility to or protection against systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and primary Sjögren's syndrome (pSS) among Chinese Han patients. We conducted a case-control study including 800 patients (300 with SLE, 350 with RA, and 150 with pSS) and 350 healthy control individuals...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28890290/the-role-of-long-non-coding-rna-h19-in-musculoskeletal-system-a-new-player-in-an-old-game
#3
REVIEW
Yang Liu, Gang Li, Jin-Fang Zhang
The long non-coding RNAs (lncRNAs) have gained much attention due to its essential roles in molecular regulation. As one of the classic lncRNAs, H19 is strongly expressed during embryogenesis and plays a crucial biological function during development. Mesenchymal stem cells (MSCs) are an ideal cell source for tissue engineering in musculoskeletal system as they own the multi-differentiation ability towards osteogenesis, adipogenesis, tenogenesis or chondrogenesis. In recent years, many studies have been found in the field of H19 mediated cellular differentiation of MSCs...
September 7, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28886306/lncrna-h19-contributes-to-rh2-mediated-mc3t3-e1cell-proliferation-by-regulation-of-osteopontin
#4
B Dong, T-T Pang
20(R)-ginsenoside Rh2 (Rh2) is one of the most active components of red ginseng, possessing the beneficial effects in cancer prevention and metabolic diseases. However, the detailed mechanisms that contribute to Rh2-mediated bone formation remain largely unknown. In this study, we assessed the expression of 17 long non-coding RNAs (lncRNAs) in cultured MC3T3-E1 cells under Rh2 treatments. We found that lncRNA H19 was significantly increased in Rh2-treated MC3T3-E1 cells. Expression of lncRNA H19 was promoted in a dose- and time-dependent manner after Rh2 treatments...
August 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28881833/lncrna-h19-mediates-bmp9-induced-osteogenic-differentiation-of-mesenchymal-stem-cells-mscs-through-notch-signaling
#5
Junyi Liao, Xinyi Yu, Xue Hu, Jiaming Fan, Jing Wang, Zhicai Zhang, Chen Zhao, Zongyue Zeng, Yi Shu, Ruyi Zhang, Shujuan Yan, Yasha Li, Wenwen Zhang, Jing Cui, Chao Ma, Li Li, Yichun Yu, Tingting Wu, Xingye Wu, Jiayan Lei, Jia Wang, Chao Yang, Ke Wu, Ying Wu, Jun Tang, Bai-Cheng He, Zhong-Liang Deng, Hue H Luu, Rex C Haydon, Russell R Reid, Michael J Lee, Jennifer Moriatis Wolf, Wei Huang, Tong-Chuan He
Mesenchymal stem cells (MSCs) are multipotent progenitor cells that can undergo self-renewal and differentiate into multiple lineages. Osteogenic differentiation from MSCs is a well-orchestrated process and regulated by multiple signaling pathways. We previously demonstrated that BMP9 is one of the most potent osteogenic factors. However, molecular mechanism through which BMP9 governs osteoblastic differentiation remains to be fully understood. Increasing evidence indicates noncoding RNAs (ncRNAs) may play important regulatory roles in many physiological and/or pathologic processes...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28879612/how-long-noncoding-rnas-enforce-their-will-on-mitochondrial-activity-regulation-of-mitochondrial-respiration-reactive-oxygen-species-production-apoptosis-and-metabolic-reprogramming-in-cancer
#6
REVIEW
Boel De Paepe, Steve Lefever, Pieter Mestdagh
The cellular transcriptome contains a wide diversity of untranslated RNAs, of which the class of regulatory long noncoding RNAs (lncRNAs) has only recently been recognized. Evidence swiftly accumulates of lncRNAs influencing mitochondrial activities of eukaryotic cells, and perturbed expression is conspicuously associated with human diseases. In this review, we describe the multifaceted effects of lncRNAs on mitochondrial function, more particularly on the balance between oxidative phosphorylation and glycolysis, on the production of reactive oxygen species, and on apoptosis in human cells...
September 6, 2017: Current Genetics
https://www.readbyqxmd.com/read/28878401/structural-basis-for-crmp2-induced-axonal-microtubule-formation
#7
Shinsuke Niwa, Fumio Nakamura, Yuri Tomabechi, Mari Aoki, Hideki Shigematsu, Takashi Matsumoto, Atsushi Yamagata, Shuya Fukai, Nobutaka Hirokawa, Yoshio Goshima, Mikako Shirouzu, Ryo Nitta
Microtubule associated protein Collapsin response mediator protein 2 (CRMP2) regulates neuronal polarity in developing neurons through interactions with tubulins or microtubules. However, how CRMP2 promotes axonal formation by affecting microtubule behavior remains unknown. This study aimed to obtain the structural basis for CRMP2-tubulin/microtubule interaction in the course of axonogenesis. The X-ray structural studies indicated that the main interface to the soluble tubulin-dimer is the last helix H19 of CRMP2 that is distinct from the known C-terminal tail-mediated interaction with assembled microtubules...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870985/whole-exome-sequencing-gives-additional-benefits-compared-to-candidate-gene-sequencing-in-the-molecular-diagnosis-of-children-with-growth-hormone-or-igf-1-insensitivity
#8
Lucy Shapiro, Sumana Chatterjee, Dina Ramadan, Kate M Davies, Martin O Savage, Louise A Metherell, Helen L Storr
GH insensitivity (GHI) is characterised by short stature, IGF-1 deficiency and normal/elevated serum GH. IGF-1 insensitivity results in pre- and post-natal growth failure with normal/high IGF-1 levels. The prevalence of genetic defects is unknown. OBJECTIVE: To identify the underlying genetic diagnoses in a paediatric cohort with GH or IGF-1 insensitivity using candidate gene (CGS) and whole exome sequencing (WES) and assess factors associated with the discovery of a genetic defect. METHODS: We undertook a prospective study of 132 patients with short stature and suspected GH or IGF-1 insensitivity referred to our centre for genetic analysis...
September 4, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28870328/sphingolipids-in-marine-microalgae-development-and-application-of-a-mass-spectrometric-method-for-global-structural-characterization-of-ceramides-and-glycosphingolipids-in-three-major-phyla
#9
Yanrong Li, Yamin Lou, Tong Mu, Aiying Ke, Zhaoshou Ran, Jilin Xu, Juanjuan Chen, Chengxu Zhou, Xiaojun Yan, Qingshan Xu, Yinghong Tan
Sphingolipid compositions are crucial for the structural and physiological properties of microalgae membranes. In the present study, we developed a quadrupole time-of-flight (Q-TOF) mass spectrometric method based on MS(E) data collection for the identification of sphingolipids with high efficiency, selectivity, sensitivity and mass accuracy and applied this method for precise structural identification and quantitative profiling of ceramides and glycosphingolipids in total lipid extracts from 17 strains of microalgae, including 11 strains of diatom, 3 strains of dinoflagellate and 3 strains of haptophyta...
September 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28867213/transgenerational-pancreatic-impairment-with-igf2-h19-epigenetic-alteration-induced-by-p-p-dde-exposure-in-early-life
#10
Yang Song, Lei Yang
The hypothesis of fetal origins indicates that exposures in early development could induce epigenetic modifications in the male germ-line, affecting the susceptibility of adult-onset disease for generations. p,p'-DDE, the primary metabolite of persistent organochlorine pesticide DDT, is highly correlated with impaired glucose tolerance (IGT) and a strong contributing factor to type 2 diabetes. In our previous study, ancestral p,p'-DDE exposure could induce transgenerational impaired male fertility with sperm Igf2 hypomethylation...
September 1, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28865728/gender-specific-association-of-exposure-to-non-dioxin-like-polychlorinated-biphenyls-during-pregnancy-with-methylation-levels-of-h19-and-long-interspersed-nuclear-element-1-in-cord-blood-in-the-hokkaido-study
#11
Sumitaka Kobayashi, Fumihiro Sata, Chihiro Miyashita, Ryu Miura, Kaoru Azumi, Sachiko Kobayashi, Houman Goudarzi, Atsuko Araki, Mayumi Ishizuka, Takashi Todaka, Jumboku Kajiwara, Tsuguhide Hori, Reiko Kishi
BACKGROUND: Associations between prenatal exposure to polychlorinated biphenyls (PCBs) and reduced birth-size, and between DNA methylation of insulin-like growth factor-2 (IGF-2), H19 locus, and long interspersed nuclear element-1 (LINE-1) and reduced birth-size are well established. To date, however, studies on the associations between prenatal exposure to PCBs and alterations in methylation of IGF-2, H19, and LINE-1 are lacking. Thus, in this study, we examined these associations with infant-gender stratification...
August 30, 2017: Toxicology
https://www.readbyqxmd.com/read/28864009/negative-uterine-asynchrony-retards-early-equine-conceptus-development-and-upregulation-of-placental-imprinted-genes
#12
Charlotte Gibson, Marta de Ruijter-Villani, Tom A E Stout
INTRODUCTION: Placental imprinted genes appear to be sensitive indicators of an inappropriate pre-implantation environment. This study examined the effects of negative uterine asynchrony after embryo transfer (ET) on early horse embryo development, and yolk-sac membrane expression of DNA methyltransferases (DNMTs) and equine specific placental imprinted genes. METHODS: Day 8 embryos were transferred to recipient mares on day 8 (synchronous) or day 3 (asynchronous) after ovulation, and conceptuses were recovered 6 or 11 days later (day 14 or 19 of development)...
September 2017: Placenta
https://www.readbyqxmd.com/read/28857495/identification-of-dysregulated-lncrnas-profiling-and-metastasis-associated-lncrnas-in-colorectal-cancer-by-genome-wide-analysis
#13
Yan Chen, Xiang Yu, Yongcan Xu, Hua Shen
The colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide, but the pathogenesis of CRC remains not well-known. Increasing studies have highlighted the critical roles of long noncoding RNAs (lncRNAs) in tumorigenesis and cancer cells metastasis, however, the expression pattern, biological roles of lncRNAs, and the mechanisms responsible for their function in CRC remain elusive. In this study, we performed a genome-wide comprehensive analysis of lncRNAs profiling and clinical relevance to identify novel lncRNAs for the further study in CRC...
August 31, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28837672/cardiac-transcriptome-profiling-of-diabetic-akita-mice-using-microarray-and-next-generation-sequencing
#14
Varun Kesherwani, Hamid R Shahshahan, Paras K Mishra
Although diabetes mellitus (DM) causes cardiomyopathy and exacerbates heart failure, the underlying molecular mechanisms for diabetic cardiomyopathy/heart failure are poorly understood. Insulin2 mutant (Ins2+/-) Akita is a mouse model of T1DM, which manifests cardiac dysfunction. However, molecular changes at cardiac transcriptome level that lead to cardiomyopathy remain unclear. To understand the molecular changes in the heart of diabetic Akita mice, we profiled cardiac transcriptome of Ins2+/- Akita and Ins2+/+ control mice using next generation sequencing (NGS) and microarray, and determined the implications of differentially expressed genes on various heart failure signaling pathways using Ingenuity pathway (IPA) analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28829794/isolation-and-characterization-of-non-o157-shiga-toxin-producing-escherichia-coli-from-beef-carcasses-cuts-and-trimmings-of-abattoirs-in-argentina
#15
Victoria Brusa, Viviana Restovich, Lucía Galli, David Teitelbaum, Marcelo Signorini, Hebe Brasesco, Alejandra Londero, Diego García, Nora Lía Padola, Valeria Superno, Marcelo Sanz, Sandra Petroli, Magdalena Costa, Mariana Bruzzone, Adriana Sucari, Marcela Ferreghini, Luciano Linares, Germán Suberbie, Ricardo Rodríguez, Gerardo A Leotta
Several foods contaminated with Shiga toxin-producing Escherichia coli (STEC) are associated with human diseases. Some countries have established microbiological criteria for non-O157 STEC, thus, the absence of serogroups O26, O45, O103, O104, O111, O121, and O145 in sprouts from the European Union or ground beef and beef trimmings from the United States is mandatory. While in Argentina screening for O26, O103, O111, O145 and O121 in ground beef, ready-to-eat food, sausages and vegetables is mandatory, other countries have zero-tolerance for all STEC in chilled beef...
2017: PloS One
https://www.readbyqxmd.com/read/28818070/rs1859168-a%C3%A2-%C3%A2-c-polymorphism-regulates-hottip-expression-and-reduces-risk-of-pancreatic-cancer-in-a-chinese-population
#16
Pinghai Hu, Ou Qiao, Jun Wang, Jiao Li, Hao Jin, Zhaolian Li, Yan Jin
BACKGROUND: Long non-coding RNAs (lncRNAs) are aberrantly expressed in many types of human cancer including pancreatic cancer (PC) and correlated with tumorigenesis and cancer prognosis, whereas knowledge about regulatory mechanism of lncRNA expression is few known. This study aimed to explore whether polymorphisms in lncRNAs genes are associated with PC susceptibility by affecting its expression. METHODS: We first genotyped three common single-nucleotide polymorphisms (SNPs) of lncRNA genes (HOTTIP rs1859168, HOTAIR rs4759314, and H19 rs217727) in 416 paired PC patients and controls, and then validated the results in another 505 paired PC patients and controls...
August 17, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28815535/history-discovery-and-classification-of-lncrnas
#17
Julien Jarroux, Antonin Morillon, Marina Pinskaya
The RNA World Hypothesis suggests that prebiotic life revolved around RNA instead of DNA and proteins. Although modern cells have changed significantly in 4 billion years, RNA has maintained its central role in cell biology. Since the discovery of DNA at the end of the nineteenth century, RNA has been extensively studied. Many discoveries such as housekeeping RNAs (rRNA, tRNA, etc.) supported the messenger RNA model that is the pillar of the central dogma of molecular biology, which was first devised in the late 1950s...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28814981/cpg-location-and-methylation-level-are-crucial-factors-for-the-early-detection-of-oral-squamous-cell-carcinoma-in-brushing-samples-using-bisulfite-sequencing-of-a-13-gene-panel
#18
Luca Morandi, Davide Gissi, Achille Tarsitano, Sofia Asioli, Andrea Gabusi, Claudio Marchetti, Lucio Montebugnoli, Maria Pia Foschini
BACKGROUND: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. The purpose of this study was to evaluate the diagnostic value of methylation level in a set of 18 genes by bisulfite next-generation sequencing...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28814771/rna-sequencing-of-db-db-mice-liver-identifies-lncrna-h19-as-a-key-regulator-of-gluconeogenesis-and-hepatic-glucose-output
#19
Neha Goyal, Ambily Sivadas, K V Shamsudheen, Rijith Jayarajan, Ankit Verma, Sridhar Sivasubbu, Vinod Scaria, Malabika Datta
Liver plays a key role in maintaining glucose homeostasis and impaired hepatic glucose metabolism is associated with type 2 diabetes. In the present study, we used RNA sequencing to profile the transcriptome of the livers of diabetic db/db mice as compared to the normal db/+ mice and identified 218 differentially expressed genes. Amongst these, there were 3 lncRNAs that were significantly downregulated and H19 was the most altered lncRNA in the livers of db/db mice. H19 expression significantly correlated with the expression of genes of the glycolysis and gluconeogenesis pathways, which suggest that altered hepatic H19 levels can directly or indirectly modulate their expression...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808260/transcriptional-profiling-identifies-differential-expression-of-long-non-coding-rnas-in-jo-1-associated-and-inclusion-body-myositis
#20
Philip D Hamann, Benoit T Roux, James A Heward, Seth Love, Neil J McHugh, Simon W Jones, Mark A Lindsay
Myositis is characterised by muscle inflammation and weakness. Although generally thought to be driven by a systemic autoimmune response, increasing evidence suggests that intrinsic changes in the muscle might also contribute to the pathogenesis. Long non-coding RNAs (lncRNAs) are a family of novel genes that regulate gene transcription and translation. To determine the potential role of lncRNAs, we employed next generation sequencing to examine the transcriptome in muscle biopsies obtained from two histologically distinct patient populations, inclusion body myositis (IBM) and anti-Jo-1-associated myositis (Jo-1)...
August 14, 2017: Scientific Reports
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