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metabolic response to trauma

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https://www.readbyqxmd.com/read/28768259/prospective-controlled-study-of-invasiveness-and-post-aggression-metabolism-in-patients-undergoing-robotic-assisted-radical-prostatectomy
#1
Andreas Martinschek, Lisa Stumm, Manuel Ritter, Elmar Heinrich, Christian Bolenz, Lutz Trojan
OBJECTIVES: To evaluate in a prospective, controlled, nonrandomized study the surgical stress and acute-phase systemic response in robotic-assisted laparoscopic prostatectomy (RALP) compared to open radical retro-pubic prostatectomy (ORRP) by measuring humoral mediators. METHODS: Forty consecutive patients undergoing either RALP or ORRP were prospectively included to assess the extent of systemic response. Blood samples were collected before surgery (T1), at the time of prostatectomy (T2), at the time of wound closure (T3), and 12 h (T4), 24 h (T5), and 48 h (T6) after surgery, and assayed for interleukins (IL-6 and IL-10), C-reactive protein (CRP), and hemoglobin...
July 29, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28758144/immune-signaling-mechanisms-of-ptsd-risk-and-symptom-development-insights-from-animal-models
#2
Jessica Deslauriers, Susan Powell, Victoria B Risbrough
Post-traumatic stress disorder (PTSD) is characterized by persistent re-experiencing of a traumatic event, avoidance, and increased arousal. The approved pharmacological treatments for PTSD have limited efficacy (~60% treatment response), supporting the need for identification of biomarkers and novel pharmacological therapies. Mounting evidence suggests increased inflammatory markers and altered immune gene expression correlate with the severity of symptoms in PTSD patients. However a causal role of immune signaling in development and maintenance of PTSD symptoms is not clear, as inflammation may also be an epiphenomenon related to metabolic and behavioral effects of stress...
April 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28741388/comparative-proteomic-analysis-of-the-effect-of-the-four-herb-chinese-medicine-anbp-on-promoting-mouse-skin-wound-healing
#3
Li Chen, Qian Hou, Zhong-Zhi Zhou, Mei-Rong Li, Ling-Zhi Zhong, Xiang-Dong Deng, Zi-Ying Zhu, Zhong-Yi Cheng, Jun Zhu, Cong-Lian Xiang, Wen-Jun He, Xiao-Bing Fu
Traditional Chinese medicine has great potential to improve wound healing. ANBP, the mixture of 4 Chinese herbs- Agrimoniapilosa, Nelumbonucifera, Boswelliacarteri, and Pollen typhae-is effective in trauma treatment while its mechanism is still elusive. In this study, quantitative proteomics and bioinformatics analyses were performed to decipher the possible roles of ANBP in accelerated wound healing of mouse skin. Among all 3171 identified proteins, 90, 71, 80, and 140 proteins were found to be differently expressed in 6 hours, 3 days, 7 days, and 14 days ANBP-treated tissues compared with corresponding control tissues, respectively...
July 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28704681/cytokine-il1%C3%AE-and-lactate-as-markers-for-tissue-damage-in-spineboard-immobilisation-a-prospective-randomised-open-label-crossover-trial
#4
Baukje Hemmes, Luuk A de Wert, Peter R G Brink, Cees W J Oomens, Dan L Bader, Martijn Poeze
BACKGROUND: Spinal immobilisation using a rigid long spineboard is a well-established procedure in trauma care. During immobilisation, the body is exposed to high tissue-interface pressures. This may lead to a localised inflammatory response of the skin, which may be used to monitor the body's response to different types of immobilisation device. AIM: In this study we compared the standard rigid spineboard with a new soft-layered spineboard regarding tissue-interface pressures, skin redness as an indicator of reactive hyperaemia and cutaneous IL1α and lactate release...
June 23, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28683495/osteoimmunology-influence-of-the-immune-system-on-bone-regeneration-and-consumption
#5
Andreas Limmer, Dieter C Wirtz
Background Stimulating bone regeneration is a central aim in orthopaedic and trauma surgery. Although the replacement of bone with artificial materials like cement or apatite helps to keep up bone stability, new bone often cannot be regenerated. Increasing research efforts have led to the clinical application of growth factors stimulating bone growth (e.g. bone morphogenic protein, BMP) and inhibitors preventing bone consumption (e.g. RANKL blocking antibodies). These factors mostly concentrate on stimulating osteoblast or preventing osteoclast activity...
June 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28682939/burn-trauma-acutely-increases-the-respiratory-capacity-and-function-of-liver-mitochondria
#6
Fredrick J Bohanon, Omar Nunez Lopez, David N Herndon, Xiaofu Wang, Nisha Bhattarai, Amina El Ayadi, Anesh Prasai, Jayson W Jay, Yesenia Rojas-Khalil, Tracy E Toliver-Kinsky, Celeste C Finnerty, Ravi S Radhakrishnan, Craig Porter
BACKGROUND: A complete understanding of the role of the liver in burn-induced hypermetabolism is lacking. We investigated the acute effect of severe burn trauma on liver mitochondrial respiratory capacity and coupling control as well as the signaling events underlying these alterations. METHODS: Male BALB/c mice (8-12 weeks) received full-thickness scald burns on ∼30% of the body surface. Liver tissue was harvested 24 hours post injury. Mitochondrial respiration was determined by high-resolution respirometry...
July 4, 2017: Shock
https://www.readbyqxmd.com/read/28625441/the-protective-effects-of-dexmedetomidine-on-ischemic-brain-injury-a-meta-analysis
#7
REVIEW
Lianxiang Jiang, Meizhu Hu, Yan Lu, Ya Cao, Yan Chang, Zeping Dai
BACKGROUND: Intracranial lesions, trauma or surgery-related damage activate immune inflammation and neuroendocrine responses, causing ischemic brain injury. Studies have shown that inflammatory cascade mediated by neuroendocrine hormones and proinflammatory mediators is implicated in the pathophysiology of ischemic brain injury. Alpha2-adrenoceptor agonists, dexmedetomidine, is widely used as neuroprotectants in anesthesia practice. However, it is still lack of a comprehensive meta-analysis to evaluate the neuroprotection of dexmedetomidine against ischemic brain injury via suppressing these two physiological responses...
August 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28614388/osteoblast-specific-overexpression-of-complement-receptor-c5ar1-impairs-fracture-healing
#8
Stephanie Bergdolt, Anna Kovtun, Yvonne Hägele, Astrid Liedert, Thorsten Schinke, Michael Amling, Markus Huber-Lang, Anita Ignatius
The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts. C5aR1 induces osteoblast migration, cytokine generation and osteoclastogenesis, however, the exact role of C5aR1-mediated signaling in osteoblasts is not entirely known. Therefore, we hypothesized that osteoblasts are essential target cells for C5a and that fracture healing should be disturbed in mice with an osteoblast-specific C5aR1 overexpression (Col1a1-C5aR1)...
2017: PloS One
https://www.readbyqxmd.com/read/28602695/-presumed-cardiac-arrest-in-children-and-young-adults-a-misnomer
#9
Katherine S Allan, Laurie J Morrison, Arnold Pinter, Jack V Tu, Paul Dorian
AIM: To use a novel methodology to assess the incidence and specific causes of Out-of-Hospital Cardiac Arrest (OHCA) within a young urban cohort. METHODS: All EMS attended OHCA patients in a large urban area, between 2009 and 2012, aged 2-45 years, treated or untreated, who died or survived, and that were designated as "no obvious cause" etiology by trained data abstractors were included. Using multisource (medical and coroner) records, an expert panel adjudicated the causes of the OHCAs as: confirmed cardiac causes, confirmed non- cardiac causes, and other causes...
June 7, 2017: Resuscitation
https://www.readbyqxmd.com/read/28590356/plasma-succinate-is-a-predictor-of-mortality-in-critically-injured-patients
#10
Angelo D'Alessandro, Hunter B Moore, Ernest E Moore, Julie A Reisz, Matthew J Wither, Arsen Ghasabyan, James Chandler, Christopher C Silliman, Kirk C Hansen, Anirban Banerjee
BACKGROUND: Trauma is the leading cause of mortality under the age of 40. Recent observations on metabolic reprogramming during hypoxia and ischemia indicate that hypoxic mitochondrial uncoupling promotes the generation of succinate, which in turn mediates reperfusion injury and inflammatory sequelae upon reoxygenation. Plasma levels of succinate significantly increase in response to trauma and hemorrhage in experimental models and clinical samples, suggesting that succinate may represent a candidate marker of systemic perfusion in trauma...
June 6, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28579457/metformin-ameliorates-gender-and-age-dependent-hemodynamic-instability-and-myocardial-injury-in-murine-hemorrhagic-shock
#11
Dzmitry Matsiukevich, Giovanna Piraino, Patrick Lahni, Paul W Hake, Vivian Wolfe, Michael O'Connor, Jeanne James, Basilia Zingarelli
Severity of multiple organ failure is significantly impacted by age and gender in patients with hemorrhagic shock. However, the molecular mechanisms underlying the enhanced organ injury are not fully understood. AMP-activated protein kinase (AMPK) is a pivotal orchestrator of metabolic responses during stress. We investigated whether hemorrhage-induced myocardial injury is age and gender dependent and whether treatment with metformin, an AMPK activator, affords cardioprotective effects. C57/BL6 young (3-5months) and mature (9-12months) male and female mice were subjected to hemorrhagic shock by blood withdrawing followed by resuscitation with blood and Lactated Ringer's solution...
June 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28539742/neutralization-of-inflammation-by-inhibiting-in-vitro-and-in-vivo-secretory-phospholipase-a2-by-ethanol-extract-of-boerhaavia-diffusa-l
#12
Aladahalli S Giresha, Siddanakoppalu N Pramod, A D Sathisha, K K Dharmappa
BACKGROUND: Inflammation is a normal and necessary prerequisite to healing of the injured tissues. Inflammation contributes to all disease process including immunity, vascular pathology, trauma, sepsis, chemical, and metabolic injuries. The secretory phospholipase A2 (sPLA2) is a key enzyme in the production of pro-inflammatory mediators in chronic inflammatory disorders such as rheumatoid arthritis, coronary heart disease, diabetes, and asthma. The sPLA2 also contribute to neuroinflammatory disorders such as Parkinson's, Alzheimer's, and Crohn's disease...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28534301/effects-of-acetyl-l-carnitine-in-diabetic-neuropathy-and-other-geriatric-disorders
#13
REVIEW
G Sergi, S Pizzato, F Piovesan, C Trevisan, N Veronese, E Manzato
A long history of diabetes mellitus and increasing age are associated with the onset of diabetic neuropathy, a painful and highly disabling complication with a prevalence peaking at 50% among elderly diabetic patients. Acetyl-L-carnitine (ALC) is a molecule derived from the acetylation of carnitine in the mitochondria that has an essential role in energy production. It has recently been proposed as a therapy to improve the symptoms of diabetic neuropathy. ALC is widely distributed in mammalian tissues, including the brain, blood-brain barrier, brain neurons, and astrocytes...
May 22, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28533056/white-matter-damage-after-traumatic-brain-injury-a-role-for-damage-associated-molecular-patterns
#14
REVIEW
Molly Braun, Kumar Vaibhav, Nancy M Saad, Sumbul Fatima, John R Vender, Babak Baban, Md Nasrul Hoda, Krishnan M Dhandapani
Traumatic brain injury (TBI) is a leading cause of mortality and long-term morbidity worldwide. Despite decades of pre-clinical investigation, therapeutic strategies focused on acute neuroprotection failed to improve TBI outcomes. This lack of translational success has necessitated a reassessment of the optimal targets for intervention, including a heightened focus on secondary injury mechanisms. Chronic immune activation correlates with progressive neurodegeneration for decades after TBI; however, significant challenges remain in functionally and mechanistically defining immune activation after TBI...
May 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28512432/whole-body-cryotherapy-in-athletes-from-therapy-to-stimulation-an-updated-review-of-the-literature
#15
REVIEW
Giovanni Lombardi, Ewa Ziemann, Giuseppe Banfi
Nowadays, whole-body cryotherapy is a medical physical treatment widely used in sports medicine. Recovery from injuries (e.g., trauma, overuse) and after-season recovery are the main purposes for application. However, the most recent studies confirmed the anti-inflammatory, anti-analgesic, and anti-oxidant effects of this therapy by highlighting the underlying physiological responses. In addition to its therapeutic effects, whole-body cryotherapy has been demonstrated to be a preventive strategy against the deleterious effects of exercise-induced inflammation and soreness...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28501568/polytrauma-induced-hepatic-stress-response-and-the-development-of-liver-insulin-resistance
#16
Robert M Akscyn, J Lee Franklin, Tatyana A Gavrikova, Joseph L Messina
Insulin resistance and metabolic dysfunction are common following injury. Polytrauma is defined as combined injuries to more than one body part or organ system, and is common in modern warfare, as well as automobile and industrial accidents. Polytrauma can include any combination of burn injury, fracture, hemorrhage, trauma to the extremities, and blunt or penetrating trauma. Multiple minor injuries are often more deleterious than a more severe single injury. To investigate the mechanisms of development of insulin resistance following injury, we have developed a rat model of polytrauma which combined soft tissue trauma with burn injury and penetrating gastrointestinal (GI) trauma...
May 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28500085/the-most-common-vices-of-men-can-damage-fertility-and-the-health-of-the-next-generation
#17
Tod Fullston, Nicole O McPherson, Deirdre Zander-Fox, Michelle Lane
There is growing evidence from animal and human studies that demonstrate that acquired paternal traits can impair both a male's fertility and the health of his offspring, including advanced age, smoking, stress, trauma, under-nutrition, infection, toxin exposure, and obesity. Curiously, many of these factors manifest as impaired neurological, behavioural, and/or metabolic functioning in offspring. The underlying molecular mechanisms that respond to the paternal environment and act as vectors of intergenerational transmission are beginning to emerge...
May 12, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28496410/clinical-applications-of-iso-inertial-eccentric-overload-yoyo%C3%A2-resistance-exercise
#18
REVIEW
Per A Tesch, Rodrigo Fernandez-Gonzalo, Tommy R Lundberg
In the quest for a viable non-gravity dependent method to "lift weights" in space, our laboratory introduced iso-inertial resistance (YoYo™) exercise using spinning flywheel(s), more than 25 years ago. After being thoroughly tested in individuals subjected to various established spaceflight analogs, a multi-mode YoYo™ exercise apparatus was eventually installed on the International Space Station in 2009. The method, applicable to any muscle group, provides accommodated resistance and optimal muscle loading through the full range of motion of concentric actions, and brief episodes of eccentric overload...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28451864/prolotherapy-induces-an-inflammatory-response-in-human-tenocytes-in-vitro
#19
Emmanuel C Ekwueme, Mahir Mohiuddin, Jazmin A Yarborough, P Gunnar Brolinson, Denitsa Docheva, Hugo A M Fernandes, Joseph W Freeman
BACKGROUND: Proliferative therapy, or prolotherapy, is a controversial treatment method for many connective tissue injuries and disorders. It involves the injection of a proliferant, or irritant solution, into the site of injury, which causes small-scale cell death. This therapeutic trauma is theorized to initiate the body's wound-healing cascade, perhaps leading to tissue repair. The immediate effects of many of these proliferants are poorly characterized, as are the cellular responses to them; here, we sought to evaluate the immediate effects of two common proliferants (dextrose and P2G, a combination of phenol, glucose, and glycerin) on the cellular response of human tenocytes, and begin to explicate the mechanisms with which each proliferant functions...
August 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28448295/the-role-of-mitochondrial-stress-in-muscle-wasting-following-severe-burn-trauma
#20
John O Ogunbileje, David N Herndon, Andrew J Murton, Craig Porter
Increased resting metabolic rate (hypermetabolism) and skeletal muscle wasting are hallmarks of the pathophysiological stress response to severe burn trauma. However, whether these two responses occur independently in burn patients or are in fact related remains unclear. In light of recent evidence demonstrating that increased proteolysis in skeletal muscle of burned patients is accompanied by mitochondrial hypermetabolism, oxidative stress, and protein damage; in this article, we discuss the evidence for a role for the mitochondrion in skeletal muscle wasting following severe burn trauma...
April 21, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
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