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Peripheral nerve surgery

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https://www.readbyqxmd.com/read/29451447/peripheral-nerve-grafts-implanted-into-the-substantia-nigra-in-patients-with-parkinson-s-disease-during-deep-brain-stimulation-surgery-1-year-follow-up-study-of-safety-feasibility-and-clinical-outcome
#1
Craig G van Horne, Jorge E Quintero, John T Slevin, Amelia Anderson-Mooney, Julie A Gurwell, Andrew S Welleford, John R Lamm, Renee P Wagner, Greg A Gerhardt
OBJECTIVE Currently, there is no treatment that slows or halts the progression of Parkinson's disease. Delivery of various neurotrophic factors to restore dopaminergic function has become a focus of study in an effort to fill this unmet need for patients with Parkinson's disease. Schwann cells provide a readily available source of such factors. This study presents a 12-month evaluation of safety and feasibility, as well as the clinical response, of implanting autologous peripheral nerve grafts into the substantia nigra of patients with Parkinson's disease at the time of deep brain stimulation (DBS) surgery...
February 16, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29447794/plasticity-after-pediatric-cochlear-implantation-implication-from-changes-in-peripheral-plasma-level-of-bdnf-and-auditory-nerve-responses
#2
Razieh Alemi, Masoud Motassadi Zarandy, Mohammad Taghi Joghataei, Ali Eftekharian, Mohammad Reza Zarrindast, Nasim Vousooghi
INTRODUCTION: Sensory neural hearing loss could lead to some structural and physiological changes in the auditory pathways, such as alteration in the expression of neurotrophins. These factors, especially Brain-Derived Neurotrophic Factor (BDNF), play an important role in synaptic functions and experience-related plasticity. Restoring cochlear function after hearing loss is possible through cochlear implantation (CI). Evaluation of the blood concentration changes of neurotrophins as prerequisites of plasticity could help scientists to determine the prognosis of CI as in the candidacy procedure or enhancing prosthesis function by adding the exact needed amount of BDNF to the electrode array...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29443722/characterizing-treatment-utilization-patterns-for-trigeminal-neuralgia-in-the-united-states
#3
Joanna M Zakrzewska, Ning Wu, John Y K Lee, Brian Werneburg, Deborah Hoffman, Ying Liu
BACKGROUND AND AIM: Trigeminal neuralgia (TN) is a rare orofacial disorder characterized by severe unilateral paroxysmal pain in the region of the fifth cranial nerve. Clinical guidelines recommend carbamazepine (only US Food and Drug Administration-approved drug for TN) and oxcarbazepine as first-line therapies. We utilized the US Truven Health MarketScan database to examine treatment patterns among patients with TN. METHODS: Included patients were aged ≥18 years, newly diagnosed with TN (≥2 TN diagnoses ≥14 days apart; no diagnosis in the prior year), continuously enrolled 1 year pre-index, with ≥3 years' follow-up post-index...
February 13, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29431049/vitamin-d-supplementation-attenuates-the-behavioral-scores-of-neuropathic-pain-in-rats
#4
Hamid Reza Banafshe, Mohammad Javad Khoshnoud, Alireza Abed, Maryam Saghazadeh, Azam Mesdaghinia
OBJECTIVE(S): Neuropathic pain due to lesion or dysfunction of the peripheral or central nervous system is often refractory to the conventional analgesics. Currently, there is no proven treatment to prevent or cure neuropathic pain. A recent surge of new data suggests the potential effects of vitamin D in the medical community. This study was designed to determine whether acute or chronic vitamin D administration was effective in alleviating symptoms of neuropathic pain in a rat model of neuropathic pain...
February 12, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29428403/the-sonic-hedgehog-signaling-pathway-regulates-inferior-alveolar-nerve-regeneration
#5
Yurie Yamada, Atsushi Ohazama, Takeyasu Maeda, Kenji Seo
Activation of Shh signaling is known to be observed following injury of the peripheral nerves such as the sciatic nerve. However, the precise role of Shh signaling during peripheral nerve regeneration is not fully understood. The inferior alveolar nerve (IAN) is most commonly injured during oral surgery. Unlike the sciatic nerve, the IAN is isolated from other craniofacial tissues, as it resides in a long bony canal within the mandible. The IAN is thus an excellent experimental model for investigating peripheral nerve regeneration...
February 8, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29422867/actin-cytoskeleton-affects-schwann-cell-migration-and-peripheral-nerve-regeneration
#6
Yaxian Wang, Qianqian Shan, Jiacheng Pan, Sheng Yi
Actin cytoskeleton regulates many essential biological functions, including cellular development, shape, polarity, and motility. The organization of actin cytoskeleton has also been associated with numerous physiological and pathological conditions, for instance, the elongation of axonal growth cone during peripheral nerve regeneration. However, the spatio-temporal expression patterns of actin cytoskeleton-related genes and the specific roles of actin cytoskeleton following peripheral nerve injury have not been fully revealed...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29421068/lean-and-green-hand-surgery
#7
REVIEW
Robert E Van Demark, Vanessa J S Smith, Anthony Fiegen
Health care in the United States is both expensive and wasteful. The cost of health care in the United States continues to increase every year. Health care spending for 2016 is estimated at $3.35 trillion. Per capita spending ($10,345 per person) is more than twice the average of other developed countries. The United States also leads the world in solid waste production (624,700 metric tons of waste in 2011). The health care industry is second only to the food industry in annual waste production. Each year, health care facilities in the United States produce 4 billion pounds of waste (660 tons per day), with as much as 70%, or around 2...
February 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29410172/impact-of-additional-treatment-of-para-lumbar-and-peripheral-nerve-diseases-after-lumbar-spine-surgery
#8
Juntaro Matsumoto, Toyohiko Isu, Kyongsong Kim, Naotaka Iwamoto, Kazuyoshi Yamazaki, Daijiro Morimoto, Masanori Isobe
INTRODUCTION: Some patients suffer failed back surgery syndrome (FBSS) after lumbar spine surgery. We report the effect of additional treatments for para-lumbar- and peripheral nerve diseases addressing residual symptoms after lumbar spine surgery. MATERIALS AND METHODS: We enrolled 74 patients (59 men and 15 women, mean age 62.9 years) who had undergone lumbar posterior decompression surgery in our department. Mean follow-up after initial lumbar surgery was 26...
January 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29406171/co-administration-of-dexamethasone-with-peripheral-nerve-block-intravenous-vs-perineural-application-systematic-review-meta-analysis-meta-regression-and-trial-sequential-analysis
#9
REVIEW
M Heesen, M Klimek, G Imberger, S E Hoeks, R Rossaint, S Straube
BACKGROUND: I.V. and perineural dexamethasone have both been found to prolong loco-regional analgesia compared with controls without dexamethasone. It is unclear whether perineural administration offers advantages when compared with i.v. dexamethasone. METHODS: A systematic literature search was performed to identify randomized controlled double-blind trials that compared i.v. with perineural dexamethasone in patients undergoing surgery. Using the random effects model, risk ratio (for binary variables), weighted mean difference (for continuous variables) and 95% confidence intervals were calculated...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29405670/low-concentration-distal-nerve-blocks-with-0-125-levobupivacaine-versus-systemic-analgesia-for-ambulatory-trapeziectomy-performed-under-axillary-block-a-randomized-controlled-trial
#10
Mireia Rodríguez, FJavier González, Sergi Sabaté, Mercedes García, Claudia Lamas, Adrià Font, Marisa Moreno, Ignasi Proubasta, M Àngels Gil, M Victoria Moral, Rolf Hoffmann
BACKGROUND: Trapeziectomy is one of the most painful procedures in ambulatory surgery. This prospective randomized trial aimed to compare postoperative pain control using distal peripheral nerve blocks (dPNB) with a low concentration of a long-acting local anaesthetic versus conventional systemic analgesia. METHODS: Fifty-two patients undergoing trapeziectomy were randomized to receive levobupivacaine 0.125% 5ml on radial and median nerves at the elbow (dNB group), or not to receive these blocks (control group)...
February 5, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29404987/enhanced-recovery-via-peripheral-nerve-block-for-open-hepatectomy
#11
Lucas W Thornblade, Yongwoo D Seo, Tracy Kwan, Jane H Cardoso, Eric Pan, Gregory Dembo, Raymond S W Yeung, James O Park
BACKGROUND: Enhanced recovery after surgery (ERAS) protocols are now commonplace in many fields of surgery, but only limited data exists for their use in hepatobiliary surgery. We implemented standardized ERAS protocols for all open hepatectomies and replaced thoracic epidurals with a transversus abdominis plane (TAP) block. METHODS: We performed a retrospective cohort study of all patients undergoing open hepatectomy during the 14 months before and 19 months after implementation of an ERAS protocol at our institution (January 2014-September 2016)...
February 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29404791/chronification-of-pain-mechanisms-current-understanding-and-clinical-implications
#12
REVIEW
Daniel J Pak, R Jason Yong, Alan David Kaye, Richard D Urman
PURPOSE OF REVIEW: The development of acute to chronic pain involves distinct pathophysiological changes in the peripheral and central nervous systems. This article reviews the mechanisms, etiologies, and management of chronic pain syndromes with updates from recent findings in the literature. RECENT FINDINGS: Chronic post-surgical pain (CPSP) is not limited to major surgeries and can develop after smaller procedures such as hernia repairs. While nerve injury has traditionally been thought to be the culprit for CPSP, it is evident that nerve-sparing surgical techniques are not completely preventative...
February 5, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29398211/peripheral-nerve-injury-after-elbow-arthroscopy-an-analysis-of-risk-factors
#13
Alexander H Jinnah, T David Luo, Ethan R Wiesler, Zhongyu Li, Gary G Poehling, Christopher J Tuohy, Benjamin R Graves, Michael T Freehill, Anastasios Papadonikolakis
PURPOSE: To identify risk factors associated with peripheral nerve injury after elbow arthroscopy and provide an updated incidence of those complications. METHODS: The elbow arthroscopies that were performed at our institution between 2006 and 2016 were identified. Over a 10-year period, 253 elbow arthroscopies were performed at our institution. Two hundred twenty-seven cases had a minimum follow-up of 4 weeks, and were included in our analysis. Minor and major nerve-related complications were recorded...
February 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29398191/spinal-hemangioma-mimicking-a-dumbbell-shaped-schwannoma-case-report-and-review-of-the-literature
#14
Kevin T Huang, Malia McAvoy, Jeffrey Helgager, Viren Vasudeva, John H Chi
Spinal hemangiomas are common, benign vascular lesions that involve the bony portion of vertebral bodies and are generally asymptomatic. Rarely, they can become aggressive and present with predominantly epidural extension, mimicking other neoplasms. We present the case of a fifty-one year old woman who presented with myelopathy and was discovered to have a large mass causing epidural spinal cord compression, thought to be due to a peripheral nerve sheath tumor. She underwent surgery for tumor debulking. Intraoperatively, the mass was found to be mostly epidural with minimal bone involvement...
February 1, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29396730/nerve-detection-during-surgery-optical-spectroscopy-for-peripheral-nerve-localization
#15
Gerrit C Langhout, Koert F D Kuhlmann, Michel W J M Wouters, Jos A van der Hage, Frits van Coevorden, Manfred Müller, Torre M Bydlon, Henricus J C M Sterenborg, Benno H W Hendriks, Theo J M Ruers
Precise nerve localization is of major importance in both surgery and regional anesthesia. Optically based techniques can identify tissue through differences in optical properties, like absorption and scattering. The aim of this study was to evaluate the potential of optical spectroscopy (diffuse reflectance spectroscopy) for clinical nerve identification in vivo. Eighteen patients (8 male, 10 female, age 53 ± 13 years) undergoing inguinal lymph node resection or resection or a soft tissue tumor in the groin were included to measure the femoral or sciatic nerve and the surrounding tissues...
February 2, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29394776/-a-rare-case-of-abdominal-malignant-triton-tumor
#16
Toshihiro Ogawa, Masao Harano, Toshiaki Morito, Kouichi Ichimura, Yasuhiro Choda, Hiroyoshi Matsukawa, Yasutomo Ojima, Hitoshi Idani, Shigehiro Shiozaki, Masazumi Okajima
A 60-year-old woman presented at our hospital with abdominal pain and vomiting.Three abdominal tumors were detected, and she was referred to our department for surgery.She underwent an enterectomy including 2 of the tumors.The third tumor could not be resected because it had invaded the superior mesenteric artery(SMA)and superior mesenteric vein(SMV). Based on positive immunohistochemistry results for S-100 protein and desmin, nerve sheath differentiation with rhabdomyoblastic differentiation was confirmed, and she was diagnosed with a malignant triton tumor(MTT)...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394670/-fluorescence-imaging-of-nerves-a-novel-trial-of-intraoperative-nerve-preservation
#17
Fumitaka Endo, Akio Sugitachi, Keisuke Koeda, Takeshi Iwaya, Yuji Akiyama, Akira Umemura, Toshimoto Kimura, Takeshi Takahara, Hiroyuki Nitta, Koki Ootsuka, Masaru Mizuno, Yusuke Kimura, Akira Sasaki
Nerve-preservation technique during surgery is important. Intraoperative nerve injury often causes permanent palsy or numbness and/or neurogenic functional disorders. To evade such intraoperative nerve injuries, we proposed a novel manner to specifically visualize peripheral nerve fibers. Low-toxic agents clinically available, amphotericin B(AmB)or fluorescein isothiocyanate(FITC)were used as neuro-indicators. In in vitro, we used Schwann cells as nerve models to basically confirm these agents effectively functioned as neural markers...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394166/migraine-surgery-an-all-or-nothing-phenomenon-prospective-evaluation-of-surgical-outcomes
#18
Lisa Gfrerer, John H Hulsen, Matthew D McLeod, Eric J Wright, William G Austen
OBJECTIVE: A detailed analysis of outcomes after migraine surgery suggests an anatomic etiology of pain, such as peripheral nerve compression, in select patients. BACKGROUND: Historically, surgeons have not played a role in the treatment of migraine. However, a subgroup of patients with extracranial anatomic triggers appear to benefit from surgical intervention. Traditionally, the determination of success or failure of migraine surgery is based on whether there is greater or less than 50% improvement of the migraine headache index (MHI) after surgery...
February 1, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29392206/reduced-intraepidermal-nerve-fiber-density-after-a-sustained-increase-in-insular-glutamate-a-proof-of-concept-study-examining-the-pathogenesis-of-small-fiber-pathology-in-fibromyalgia
#19
Steven E Harte, Daniel J Clauw, John M Hayes, Eva L Feldman, Irene C St Charles, Christopher J Watson
Introduction: Neuroimaging reveals increased glutamate within the insula of patients with fibromyalgia (FM), suggesting a link between FM symptoms and increased central excitatory neurotransmission. Many patients with FM also present with decreased intraepidermal nerve fiber density (IENFD), consistent with small fiber pathology. It remains unknown, however, whether either of these mechanistic findings represent a cause or a consequence of the other. This study tests the hypothesis that an excitatory imbalance within the insula leads to small fiber pathology...
May 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29382110/intraneural-platelet-rich-plasma-injections-for-the-treatment-of-radial-nerve-section-a-case-report
#20
Unai García de Cortázar, Sabino Padilla, Enrique Lobato, Diego Delgado, Mikel Sánchez
The radial nerve is the most frequently injured nerve in the upper extremity. Numerous options in treatment have been described for radial nerve injury, such as neurolysis, nerve grafts, or tendon transfers. Currently, new treatment options are arising, such as platelet-rich plasma (PRP), an autologous product with proved therapeutic effect for various musculoskeletal disorders. We hypothesized that this treatment is a promising alternative for this type of nerve pathology. The patient was a healthy 27-year-old man who suffered a deep and long cut in the distal anterolateral region of the right arm...
January 29, 2018: Journal of Clinical Medicine
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