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https://www.readbyqxmd.com/read/28430554/role-of-cerebrospinal-fluid-in-spaceflight-induced-ocular-changes-and-visual-impairment-in-astronauts
#1
Noam Alperin, Ahmet M Bagci, Carlos J Oliu, Sang H Lee, Byron L Lam
Purpose To determine the respective roles of vascular and cerebrospinal fluids in spaceflight-induced vision impairment in astronauts, known as the visual impairment and intracranial pressure (VIIP) syndrome. Materials and Methods This retrospective study was approved by the National Aeronautics and Space Administration institutional review board and is HIPAA compliant. All subjects provided written informed consent. Magnetic resonance (MR) imaging data from nine astronauts (mean age, 46.9 years) who flew on the space shuttle (14...
April 21, 2017: Radiology
https://www.readbyqxmd.com/read/28427408/time-averaged-simulated-microgravity-tasmg-inhibits-proliferation-of-lymphoma-cells-l-540-and-hdlm-2-using-a-3d-clinostat
#2
Yoon Jae Kim, Ae Jin Jeong, Myungjoon Kim, Chiwon Lee, Sang-Kyu Ye, Sungwan Kim
BACKGROUND: Gravity is omnipresent on Earth; however, humans in space, such as astronauts at the International Space Station, experience microgravity. Long-term exposure to microgravity is considered to elicit physiological changes, such as muscle atrophy, in the human body. In addition, certain types of cancer cells demonstrate inhibited proliferation under condition of time-averaged simulated microgravity (taSMG). However, the response of human Hodgkin's lymphoma cancer cells to reduced gravity, and the associated physiological changes in these cells, have not been elucidated...
April 20, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28421821/modeling-and-dynamic-simulation-of-astronaut-s-upper-limb-motions-considering-counter-torques-generated-by-the-space-suit
#3
Jingwen Li, Qing Ye, Li Ding, Qianfang Liao
Extravehicular activity (EVA) is an inevitable task for astronauts to maintain proper functions of both the spacecraft and the space station. Both experimental research in a microgravity simulator (e.g. neutral buoyancy tank, zero-g aircraft or a drop tower/tube) and mathematical modeling were used to study EVA to provide guidance for the training on Earth and task design in space. Modeling has become more and more promising because of its efficiency. Based on the task analysis, almost 90% of EVA activity is accomplished through upper limb motions...
April 19, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28417839/mortality-due-to-cardiovascular-disease-among-apollo-lunar-astronauts
#4
Robert J Reynolds, Steven M Day
INTRODUCTION: Recent research has postulated increased cardiovascular mortality for astronauts who participated in the Apollo lunar missions. The conclusions, however, are based on small numbers of astronauts, are derived from methods with known weaknesses, and are not consistent with prior research. METHODS: Records for NASA astronauts and U.S. Air Force astronauts were analyzed to produce standardized mortality ratios. Lunar astronauts were compared to astronauts who have never flown in space (nonflight astronauts), those who have only flown missions in low Earth orbit (LEO astronauts), and the U...
May 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28372057/a-study-of-voice-production-characteristics-of-astronuat-speech-during-apollo-11-for-speaker-modeling-in-space
#5
Chengzhu Yu, John H L Hansen
Human physiology has evolved to accommodate environmental conditions, including temperature, pressure, and air chemistry unique to Earth. However, the environment in space varies significantly compared to that on Earth and, therefore, variability is expected in astronauts' speech production mechanism. In this study, the variations of astronaut voice characteristics during the NASA Apollo 11 mission are analyzed. Specifically, acoustical features such as fundamental frequency and phoneme formant structure that are closely related to the speech production system are studied...
March 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28360122/increased-cerebral-blood-volume-pulsatility-during-head-down-tilt-with-elevated-carbon-dioxide-the-spacecot-study
#6
Gary E Strangman, Quan Zhang, Karina Marshall-Goebel, Edwin Mulder, Brian Stevens, Jonathan B Clark, Eric M Bershad
Astronauts aboard the International Space Station (ISS) have exhibited hyperopic shifts, posterior eye globe flattening, dilated optic nerve sheaths, and even optic disc swelling from spaceflight. Elevated intracranial pressure (ICP) consequent to cephalad fluid shifts is commonly hypothesized as contributing to these ocular changes. Head-down tilt (HDT) is frequently utilized as an Earth-based analog to study similar fluid shifts. Sealed environments like the ISS also exhibit elevated carbon dioxide (CO2), a potent arteriolar vasodilator that could further affect cerebral blood volume and flow, intracranial compliance, and ICP...
March 30, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28357491/acid-sphingomyelinase-ceramide-regulates-carotid-intima-media-thickness-in-simulated-weightless-rats
#7
Yao-Ping Cheng, Hai-Jun Zhang, Yu-Ting Su, Xing-Xing Meng, Xiao-Ping Xie, Yao-Ming Chang, Jun-Xiang Bao
Structural adaptation of arteries to weightlessness might lower the working ability or even threaten the physical health of astronauts, but the underlying mechanism is unclear. Acid sphingomyelinase (ASM) catalyzes ceramide (Cer) generation controlling arterial remodeling through multiple signaling pathways. In the present study, we aimed to investigate the contribution of ASM/Cer to the changes of common carotid artery intima-media thickness (CIMT) induced by simulated weightlessness. Hindlimb-unloaded tail-suspended (HU) rats were used to simulate the effect of weightlessness...
March 29, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28341594/itraq-based-proteomics-analysis-of-hippocampus-in-spatial-memory-deficiency-rats-induced-by-simulated-microgravity
#8
Tingmei Wang, Hailong Chen, Ke Lv, Guohua Ji, Yongliang Zhang, Yanli Wang, Yinghui Li, Lina Qu
It has been demonstrated that simulated microgravity (SM) may lead to cognitive dysfunction. However, the underlying mechanism remains unclear. In present study, tail-suspension (30°) rat was employed to explore the effects of 28 days of SM on hippocampus-dependent learning and memory capability and the underlying mechanisms. We found that 28-day tail-suspension rats displayed decline of learning and memory ability in Morris water maze (MWM) test. Using iTRAQ-based proteomics analysis, a total of 4774 proteins were quantified in hippocampus...
March 22, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28340597/temporal-dynamics-of-the-gut-microbiota-in-people-sharing-a-confined-environment-a-520-day-ground-based-space-simulation-mars500
#9
Silvia Turroni, Simone Rampelli, Elena Biagi, Clarissa Consolandi, Marco Severgnini, Clelia Peano, Sara Quercia, Matteo Soverini, Franck G Carbonero, Giovanna Bianconi, Petra Rettberg, Francesco Canganella, Patrizia Brigidi, Marco Candela
BACKGROUND: The intestinal microbial communities and their temporal dynamics are gaining increasing interest due to the significant implications for human health. Recent studies have shown the dynamic behavior of the gut microbiota in free-living, healthy persons. To date, it is not known whether these dynamics are applicable during prolonged life sharing in a confined and controlled environment. RESULTS: The MARS500 project, the longest ground-based space simulation ever, provided us with a unique opportunity to trace the crew microbiota over 520 days of isolated confinement, such as that faced by astronauts in real long-term interplanetary space flights, and after returning to regular life, for a total of 2 years...
March 24, 2017: Microbiome
https://www.readbyqxmd.com/read/28296928/the-probability-and-severity-of-decompression-sickness
#10
Laurens E Howle, Paul W Weber, Ethan A Hada, Richard D Vann, Petar J Denoble
Decompression sickness (DCS), which is caused by inert gas bubbles in tissues, is an injury of concern for scuba divers, compressed air workers, astronauts, and aviators. Case reports for 3322 air and N2-O2 dives, resulting in 190 DCS events, were retrospectively analyzed and the outcomes were scored as (1) serious neurological, (2) cardiopulmonary, (3) mild neurological, (4) pain, (5) lymphatic or skin, and (6) constitutional or nonspecific manifestations. Following standard U.S. Navy medical definitions, the data were grouped into mild-Type I (manifestations 4-6)-and serious-Type II (manifestations 1-3)...
2017: PloS One
https://www.readbyqxmd.com/read/28294181/three-dimensional-approach-to-investigating-biological-effects-along-energetic-ion-beam-pathways
#11
Xinglin Li, Shuguang Sun, Shanying Wang, Wenjian Li, Ying Qu, Weidong Cui, Tianren Sun, Jian Zhang, Jufang Wang, Guangming Zhou, Shuli Man, Yi Chen, Fuping Lu, Zengquan Wei, Genming Jin
Heavy ion beams have many exciting applications, including radiotherapy of deep-seated tumors and simulation tests of space irradiation for astronauts. These beams often use a feature that concentrates the energy deposition largely along the end of the energy pathway, leading to different distributions of biological effects along the axial direction. Currently, there is relatively little information regarding the radial directional difference of biological effects along the heavy ion paths. This study utilized a filter membrane that was quantatively applied with cells to demonstrate a 3D distribution model of irradiation on biological effects in living organisms...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28279267/astronaut-adherence-to-exercise-based-reconditioning-psychological-considerations-and-future-directions
#12
Carly D McKay, Martyn Standage
INTRODUCTION: Exercise-based reconditioning is essential for mitigating the negative physiological and functional effects of spaceflight. Astronaut adherence to prescribed reconditioning programmes is imperative, but there has been limited research in this area. PURPOSE: This commentary discusses adherence predictors in analogous terrestrial populations (sport, clinical rehabilitation, general exercise) that may translate to spaceflight environments. IMPLICATIONS: Reconditioning programmes should foster intrinsic motivation, realistic outcome expectancies, self-regulation skills, and strong therapeutic alliances to promote ongoing exercise adherence...
January 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28279266/parallels-between-astronauts-and-terrestrial-patients-taking-physiotherapy-rehabilitation-to-infinity-and-beyond
#13
Julie Hides, Gunda Lambrecht, Gita Ramdharry, Rebecca Cusack, Jacob Bloomberg, Maria Stokes
Exposure to the microgravity environment induces physiological changes in the cardiovascular, musculoskeletal and sensorimotor systems in healthy astronauts. As space agencies prepare for extended duration missions, it is difficult to predict the extent of the effects that prolonged exposure to microgravity will have on astronauts. Prolonged bed rest is a model used by space agencies to simulate the effects of spaceflight on the human body, and bed rest studies have provided some insights into the effects of immobilisation and inactivity...
January 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28275377/impact-of-particle-irradiation-on-the-immune-system-from-the-clinic-to-mars
#14
REVIEW
Rodrigo Fernandez-Gonzalo, Sarah Baatout, Marjan Moreels
Despite the generalized use of photon-based radiation (i.e., gamma rays and X-rays) to treat different cancer types, particle radiotherapy (i.e., protons and carbon ions) is becoming a popular, and more effective tool to treat specific tumors due to the improved physical properties and biological effectiveness. Current scientific evidence indicates that conventional radiation therapy affects the tumor immunological profile in a particular manner, which in turn, might induce beneficial effects both at local and systemic (i...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28271409/the-effect-of-spaceflight-and-microgravity-on-the-human-brain
#15
Angelique Van Ombergen, Athena Demertzi, Elena Tomilovskaya, Ben Jeurissen, Jan Sijbers, Inessa B Kozlovskaya, Paul M Parizel, Paul H Van de Heyning, Stefan Sunaert, Steven Laureys, Floris L Wuyts
Microgravity, confinement, isolation, and immobilization are just some of the features astronauts have to cope with during space missions. Consequently, long-duration space travel can have detrimental effects on human physiology. Although research has focused on the cardiovascular and musculoskeletal system in particular, the exact impact of spaceflight on the human central nervous system remains to be determined. Previous studies have reported psychological problems, cephalic fluid shifts, neurovestibular problems, and cognitive alterations, but there is paucity in the knowledge of the underlying neural substrates...
March 7, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28248986/cellular-responses-and-gene-expression-profile-changes-due-to-bleomycin-induced-dna-damage-in-human-fibroblasts-in-space
#16
Tao Lu, Ye Zhang, Yared Kidane, Alan Feiveson, Louis Stodieck, Fathi Karouia, Govindarajan Ramesh, Larry Rohde, Honglu Wu
Living organisms in space are constantly exposed to radiation, toxic chemicals or reactive oxygen species generated due to increased levels of environmental and psychological stresses. Understanding the impact of spaceflight factors, microgravity in particular, on cellular responses to DNA damage is essential for assessing the radiation risk for astronauts and the mutation rate in microorganisms. In a study conducted on the International Space Station, confluent human fibroblasts in culture were treated with bleomycin for three hours in the true microgravity environment...
2017: PloS One
https://www.readbyqxmd.com/read/28242876/rapid-adaptation-to-microgravity-in-mammalian-macrophage-cells
#17
Cora S Thiel, Diane de Zélicourt, Svantje Tauber, Astrid Adrian, Markus Franz, Dana M Simmet, Kathrin Schoppmann, Swantje Hauschild, Sonja Krammer, Miriam Christen, Gesine Bradacs, Katrin Paulsen, Susanne A Wolf, Markus Braun, Jason Hatton, Vartan Kurtcuoglu, Stefanie Franke, Samuel Tanner, Samantha Cristoforetti, Beate Sick, Bertold Hock, Oliver Ullrich
Despite the observed severe effects of microgravity on mammalian cells, many astronauts have completed long term stays in space without suffering from severe health problems. This raises questions about the cellular capacity for adaptation to a new gravitational environment. The International Space Station (ISS) experiment TRIPLE LUX A, performed in the BIOLAB laboratory of the ISS COLUMBUS module, allowed for the first time the direct measurement of a cellular function in real time and on orbit. We measured the oxidative burst reaction in mammalian macrophages (NR8383 rat alveolar macrophages) exposed to a centrifuge regime of internal 0 g and 1 g controls and step-wise increase or decrease of the gravitational force in four independent experiments...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220892/epigenetic-determinants-of-space-radiation-induced-cognitive-dysfunction
#18
Munjal M Acharya, Al Anoud D Baddour, Takumi Kawashita, Barrett D Allen, Amber R Syage, Thuan H Nguyen, Nicole Yoon, Erich Giedzinski, Liping Yu, Vipan K Parihar, Janet E Baulch
Among the dangers to astronauts engaging in deep space missions such as a Mars expedition is exposure to radiations that put them at risk for severe cognitive dysfunction. These radiation-induced cognitive impairments are accompanied by functional and structural changes including oxidative stress, neuroinflammation, and degradation of neuronal architecture. The molecular mechanisms that dictate CNS function are multifaceted and it is unclear how irradiation induces persistent alterations in the brain. Among those determinants of cognitive function are neuroepigenetic mechanisms that translate radiation responses into altered gene expression and cellular phenotype...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28212708/development-and-performance-evaluation-of-a-three-dimensional-clinostat-synchronized-heavy-ion-irradiation-system
#19
Hiroko Ikeda, Hikaru Souda, Anggraeini Puspitasari, Kathryn D Held, Jun Hidema, Takeshi Nikawa, Yukari Yoshida, Tatsuaki Kanai, Akihisa Takahashi
Outer space is an environment characterized by microgravity and space radiation, including high-energy charged particles. Astronauts are constantly exposed to both microgravity and radiation during long-term stays in space. However, many aspects of the biological effects of combined microgravity and space radiation remain unclear. We developed a new three-dimensional (3D) clinostat synchronized heavy-ion irradiation system for use in ground-based studies of the combined exposures. Our new system uses a particle accelerator and a respiratory gating system from heavy-ion radiotherapy to irradiate samples being rotated in the 3D clinostat with carbon-ion beams only when the samples are in the horizontal position...
February 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28212706/sclerostin-antibody-inhibits-skeletal-deterioration-in-mice-exposed-to-partial-weight-bearing
#20
J M Spatz, R Ellman, A M Cloutier, L Louis, M van Vliet, D Dwyer, M Stolina, H Z Ke, M L Bouxsein
Whereas much is known regarding the musculoskeletal responses to full unloading, little is known about the physiological effects and response to pharmacological agents in partial unloading (e.g. Moon and Mars) environments. To address this, we used a previously developed ground-based model of partial weight-bearing (PWB) that allows chronic exposure to reduced weight-bearing in mice to determine the effects of murine sclerostin antibody (SclAbII) on bone microstructure and strength across different levels of mechanical unloading...
February 2017: Life Sciences in Space Research
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