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https://www.readbyqxmd.com/read/29047238/identification-of-10-candidate-biomarkers-distinguishing-tuberculous-and-malignant-pleural-fluid-by-proteomic-methods
#1
Chang Youl Lee, Ji Young Hong, Myung Goo Lee, In Bum Suh
PURPOSE: Pleural effusion, an accumulation of fluid in the pleural space, usually occurs in patients when the rate of fluid formation exceeds the rate of fluid removal. The differential diagnosis of tuberculous pleurisy and malignant pleural effusion is a difficult task in high tuberculous prevalence areas. The aim of the present study was to identify novel biomarkers for the diagnosis of pleural fluid using proteomics technology. MATERIALS AND METHODS: We used samples from five patients with transudative pleural effusions for internal standard, five patients with tuberculous pleurisy, and the same numbers of patients having malignant effusions were enrolled in the study...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29046178/a-psychiatric-formulary-for-long-duration-spaceflight
#2
Eric Friedman, Brian Bui
Behavioral health is essential for the safety, well-being, and performance of crewmembers in both human spaceflight and Antarctic exploration. Over the past five decades, psychiatric issues have been documented in orbital spaceflight. In Antarctica, literature suggests up to 5% of wintering crewmembers could meet criteria for a psychiatric illness, including mood disorders, stressor-related disorders, sleep-wake disorders, and substance-related disorders. Experience from these settings indicates that psychiatric disorders on deep space missions must be anticipated...
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29028400/label-free-study-of-cosmonaut-s-urinary-proteome-changes-after-long-duration-spaceflights
#3
A Brzhozovskiy, A Kononikhin, M Indeykina, LKh Pastushkova, I A Popov, E N Nikolaev, I M Larina
During the entire time that cosmonauts stay on board the international space station, different extreme space flight factors affect their bodies. In order to find out what physiological changes occur under the influence of spaceflight, different parameters of the human body before and after flights are monitored. Analysis of the urine proteome is one of the most perspective non-invasive methods of condition monitoring. The aim of the study was to perform a comparative semi-quantitative label-free urine proteome analysis of samples collected from 21 cosmonauts before and after long-duration spaceflight at the international space station...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29023458/emergence-of-encounter-networks-due-to-human-mobility
#4
A P Riascos, José L Mateos
There is a burst of work on human mobility and encounter networks. However, the connection between these two important fields just begun recently. It is clear that both are closely related: Mobility generates encounters, and these encounters might give rise to contagion phenomena or even friendship. We model a set of random walkers that visit locations in space following a strategy akin to Lévy flights. We measure the encounters in space and time and establish a link between walkers after they coincide several times...
2017: PloS One
https://www.readbyqxmd.com/read/29021738/erratum-expanding-lorentz-and-spectrum-corrections-to-large-volumes-of-reciprocal-space-for-single-crystal-time-of-flight-neutron-diffraction-corrigendum
#5
Tara M Michels-Clark, Andrei T Savici, Vickie E Lynch, Xiaoping Wang, Michal Chodkiewicz, Thomas Weber, Hans-Beat Bürgi, Christina M Hoffmann
[This corrects the article DOI: 10.1107/S1600576716001369.].
October 1, 2017: Journal of Applied Crystallography
https://www.readbyqxmd.com/read/29018320/virtual-balancing-for-studying-and-training-postural-control
#6
Daniela Buettner, Daniela Dalin, Isabella K Wiesmeier, Christoph Maurer
Postural control during free stance has been frequently interpreted in terms of balancing an inverted pendulum. This even holds, if subjects do not balance their own, but an external body weight. We introduce here a virtual balancing apparatus, which produces torque in the ankle joint as a function of ankle angle resembling the gravity and inertial effects of free standing. As a first aim of this study, we systematically modified gravity, damping, and inertia to examine its effect on postural control beyond the physical constraints given in the real world...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28993729/differential-impact-of-single-dose-fe-ion-and-x-ray-irradiation-on-endothelial-cell-transcriptomic-and-proteomic-responses
#7
Bjorn Baselet, Omid Azimzadeh, Nadine Erbeldinger, Mayur V Bakshi, Till Dettmering, Ann Janssen, Svetlana Ktitareva, Donna J Lowe, Arlette Michaux, Roel Quintens, Kenneth Raj, Marco Durante, Claudia Fournier, Mohammed A Benotmane, Sarah Baatout, Pierre Sonveaux, Soile Tapio, An Aerts
Background and Purpose: Radiotherapy is an essential tool for cancer treatment. In order to spare normal tissues and to reduce the risk of normal tissue complications, particle therapy is a method of choice. Although a large part of healthy tissues can be spared due to improved depth dose characteristics, little is known about the biological and molecular mechanisms altered after particle irradiation in healthy tissues. Elucidation of these effects is also required in the context of long term space flights, as particle radiation is the main contributor to the radiation effects observed in space...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28993482/the-prediction-of-impact-of-a-looming-stimulus-onto-the-body-is-subserved-by-multisensory-integration-mechanisms
#8
Justine Cléry, Olivier Guipponi, Soline Odouard, Serge Pinède, Claire Wardak, Suliann Ben Hamed
In the jungle, survival is highly correlated with the ability to detect and distinguish between an approaching predator and a putative prey. From an ecological perspective, a predator rapidly approaching its prey is a stronger cue for flight than a slowly moving predator. In the present study, we use functional magnetic resonance imaging (fMRI) in the non-human primate, to investigate the neural bases of the prediction of an impact to the body by a looming stimulus, i.e. the neural bases of the interaction between a dynamic visual stimulus approaching the body and its expected consequences onto an independent sensory modality, namely, touch...
October 9, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28981964/long-distance-flights-and-high-risk-breeding-by-nomadic-waterbirds-on-desert-salt-lakes
#9
Reece D Pedler, Raoul F H Ribot, Andrew T D Bennett
Understanding and conserving mobile species presents complex challenges, especially for animals in stochastic or changing environments. Nomadic waterbirds must locate temporary water in arid biomes where rainfall is highly unpredictable in space and time. To achieve this they need to travel over vast spatial scales and time arrival to exploit pulses in food resources. How they achieve this is an enduring mystery.  We investigated these challenges in the colonial-nesting Banded Stilt (Cladorhynchus leucocephalus), a nomadic shorebird of conservation concern...
October 5, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28974259/preparing-for-the-crewed-mars-journey-microbiota-dynamics-in-the-confined-mars500-habitat-during-simulated-mars-flight-and-landing
#10
Petra Schwendner, Alexander Mahnert, Kaisa Koskinen, Christine Moissl-Eichinger, Simon Barczyk, Reinhard Wirth, Gabriele Berg, Petra Rettberg
BACKGROUND: The Mars500 project was conceived as the first full duration simulation of a crewed return flight to Mars. For 520 days, six crew members lived confined in a specifically designed spacecraft mock-up. The herein described "MIcrobial ecology of Confined Habitats and humAn health" (MICHA) experiment was implemented to acquire comprehensive microbiota data from this unique, confined manned habitat, to retrieve important information on the occurring microbiota dynamics, the microbial load and diversity in the air and on various surfaces...
October 4, 2017: Microbiome
https://www.readbyqxmd.com/read/28963810/synthesis-and-characterization-of-polycyclic-aromatic-hydrocarbons-with-different-space-constructions-based-on-the-hexaphenylbenzene-derivatives
#11
Weizhi Wang, Hua Chen, Hao Yun Zhu, Yu Li Huang, Jun Wei Yang
In recent years, low-bandgap polymers have attracted a wide range of attention in many fields. These compounds syntheses were focused on three factors according to the Roncali bandgap theory: 1) the degree of bond length alternation Eδr, 2) the aromatic resonance energy of the cycle ERes, and 3) the substituted groups ESub. Now, we designed and prepared the low-bandgap polymers in a different way by the factor Eθ, the polymer chain deviation from planarity, and EInt, the interaction of the molecular chains in the solid state...
September 30, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28962911/from-the-international-space-station-to-the-clinic-how-prolonged-unloading-may-disrupt-lumbar-spine-stability
#12
Jeannie F Bailey, Stephanie L Miller, Kristine Khieu, Conor W O'Neill, Robert M Healey, Dezba G Coughlin, Jojo V Sayson, Douglas G Chang, Alan R Hargens, Jeffrey C Lotz
Background context Prolonged microgravity exposure is associated with localized low back pain and an elevated risk of post-flight disc herniation. Though the mechanisms by which microgravity impairs the spine are unclear, they should be foundational for developing in-flight countermeasures for maintaining astronaut spine health. Because human spine anatomy has adapted to upright posture on Earth, observations of how spaceflight affects the spine should also provide new and potentially important information on spine biomechanics that benefit the general population...
September 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28960477/real-time-ultrasound-assessment-of-astronaut-spinal-anatomy-and-disorders-on-the-international-space-station
#13
Kathleen M Garcia, Michael F Harrison, Ashot E Sargsyan, Douglas Ebert, Scott A Dulchavsky
OBJECTIVES: Back pain is one of the most common conditions of astronauts during spaceflight and is hypothesized to be attributed to pathologic anatomic changes. Ultrasound (US) represents the only available imaging modality on the International Space Station, but a formal US protocol for imaging the structures of the spinal column does not exist. This investigation developed a method of acquiring diagnostic-quality images of the anterior lumbar and cervical regions of the spine during long-duration spaceflight...
September 29, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28956839/adaptation-of-dubins-paths-for-uav-ground-obstacle-avoidance-when-using-a-low-cost-on-board-gnss-sensor
#14
Ramūnas Kikutis, Jonas Stankūnas, Darius Rudinskas, Tadas Masiulionis
Current research on Unmanned Aerial Vehicles (UAVs) shows a lot of interest in autonomous UAV navigation. This interest is mainly driven by the necessity to meet the rules and restrictions for small UAV flights that are issued by various international and national legal organizations. In order to lower these restrictions, new levels of automation and flight safety must be reached. In this paper, a new method for ground obstacle avoidance derived by using UAV navigation based on the Dubins paths algorithm is presented...
September 28, 2017: Sensors
https://www.readbyqxmd.com/read/28950513/anisotropic-interaction-rules-in-circular-motions-of-pigeon-flocks-an-empirical-study-based-on-sparse-bayesian-learning
#15
Duxin Chen, Bowen Xu, Tao Zhu, Tao Zhou, Hai-Tao Zhang
Coordination shall be deemed to the result of interindividual interaction among natural gregarious animal groups. However, revealing the underlying interaction rules and decision-making strategies governing highly coordinated motion in bird flocks is still a long-standing challenge. Based on analysis of high spatial-temporal resolution GPS data of three pigeon flocks, we extract the hidden interaction principle by using a newly emerging machine learning method, namely the sparse Bayesian learning. It is observed that the interaction probability has an inflection point at pairwise distance of 3-4 m closer than the average maximum interindividual distance, after which it decays strictly with rising pairwise metric distances...
August 2017: Physical Review. E
https://www.readbyqxmd.com/read/28941951/on-decentralized-adaptive-full-order-sliding-mode-control-of-multiple-uavs
#16
Xianbo Xiang, Chao Liu, Housheng Su, Qin Zhang
In this study, a novel decentralized adaptive full-order sliding mode control framework is proposed for the robust synchronized formation motion of multiple unmanned aerial vehicles (UAVs) subject to system uncertainty. First, a full-order sliding mode surface in a decentralized manner is designed to incorporate both the individual position tracking error and the synchronized formation error while the UAV group is engaged in building a certain desired geometric pattern in three dimensional space. Second, a decentralized virtual plant controller is constructed which allows the embedded low-pass filter to attain the chattering free property of the sliding mode controller...
September 20, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28918418/new-aspects-in-the-pathomechanism-of-diseases-of-civilization-particularly-psychosomatic-disorders-part-1-theoretical-background-of-a-hypothesis
#17
Andras Sikter, Zoltan Rihmer, Roberto de Guevara
The stress defence-cascade is mostly not biphasic as Cannon thought, the sympathicotonic stress response is preceded by a vagotonic phase called freeze response. Alteration of the carbon dioxide level plays an important role during defence-cascade as its changes interfere with stress hormones, e.g. with catecholamines, thus affecting the degree of arousal. In case of humans, learned behaviour dominates instead of instinctive, so the fight-or-flight often lags; the consequence can be persistent hypocapnia or hypercapnia...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28910671/delayed-effects-of-accelerated-heavy-ions-on-the-induction-of-hprt-mutations-in-v79-hamster-cells
#18
Pavel Bláha, Nataliya A Koshlan, Igor V Koshlan, Daria V Petrova, Yulia V Bogdanova, Raisa D Govorun, Viliam Múčka, Evgeny A Krasavin
Fundamental research on the harmful effects of ionizing radiation on living cells continues to be of great interest. Recently, priority has been given to the study of high-charge and high-energy (HZE) ions that comprise a substantial part of the galactic cosmic ray (GCR) spectra that would be encountered during long-term space flights. Moreover, predictions of the delayed genetic effects of high linear energy transfer (LET) exposure is becoming more important as heavy ion therapy use is increasing. This work focuses mainly on the basic research on the delayed effects of HZE ions on V79 Chinese hamster cells, with emphasis on the induction of HPRT mutations after prolonged expression times (ET)...
October 2017: Mutation Research
https://www.readbyqxmd.com/read/28910670/mental-imagery-of-gravitational-motion
#19
Silvio Gravano, Myrka Zago, Francesco Lacquaniti
There is considerable evidence that gravitational acceleration is taken into account in the interaction with falling targets through an internal model of Earth gravity. Here we asked whether this internal model is accessed also when target motion is imagined rather than real. In the main experiments, naïve participants grasped an imaginary ball, threw it against the ceiling, and caught it on rebound. In different blocks of trials, they had to imagine that the ball moved under terrestrial gravity (1g condition) or under microgravity (0g) as during a space flight...
August 9, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28904800/alterations-in-hematologic-indices-during-long-duration-spaceflight
#20
Hawley Kunz, Heather Quiriarte, Richard J Simpson, Robert Ploutz-Snyder, Kathleen McMonigal, Clarence Sams, Brian Crucian
BACKGROUND: Although a state of anemia is perceived to be associated with spaceflight, to date a peripheral blood hematologic assessment of red blood cell (RBC) indices has not been performed during long-duration space missions. METHODS: This investigation collected whole blood samples from astronauts participating in up to 6-months orbital spaceflight, and returned those samples (ambient storage) to Earth for analysis. As samples were always collected near undock of a returning vehicle, the delay from collection to analysis never exceeded 48 h...
2017: BMC Hematology
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