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https://www.readbyqxmd.com/read/28323933/research-resource-transcriptional-dynamics-of-cultured-human-villous-cytotrophoblasts
#1
Joshua F Robinson, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Terrence Dent, Helia Seifikar, Emily G Hamilton, Susan J Fisher
During human pregnancy, cytotrophoblasts (CTBs) play key roles in uterine invasion, vascular remodeling, and anchoring of the feto-placental unit. Due to the challenges associated with studying human placentation in utero, cultured primary villous CTBs are used as a model of the differentiation pathway that leads to invasion of the uterine wall. In vitro, CTBs emulate in vivo cell behaviors, such as migration, aggregation and substrate penetration. While some of the molecular features related to these cell behaviors have been described, the underlying mechanisms, at a global level, remain undefined at mid-gestation...
March 8, 2017: Endocrinology
https://www.readbyqxmd.com/read/28322505/evaluation-of-the-efficacy-and-color-stability-of-two-different-at-home-bleaching-systems-on-teeth-of-different-shades-a-randomized-controlled-clinical-trial
#2
Betül Aka, Esra Uzer Celik
OBJECTIVE: This randomized controlled clinical trial compared the bleaching efficacy of two different at-home bleaching systems on teeth of different shades and their color stability after a 6-month follow-up. MATERIALS AND METHODS: Ninety-two patients (777 teeth) were randomly divided into three groups: (a) negative control, (b) patients treated with a custom-made tray containing 10% carbamide peroxide (10% CP/PF) (Opalescence PF), and (c) patients treated with a pre-loaded tray containing 6% hydrogen peroxide (6% HP/Go) (Opalescence Go)...
March 21, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28318045/diagnosis-of-gastro-oesophageal-reflux-disease-is-enhanced-by-adding-oesophageal-histology-and-excluding-epigastric-pain
#3
N Vakil, M Vieth, B Wernersson, J Wissmar, J Dent
BACKGROUND: The diagnosis of gastro-oesophageal reflux disease (GERD) in clinical practice is limited by the sensitivity and specificity of symptoms and diagnostic testing. AIM: To determine if adding histology as a criterion and excluding patients with epigastric pain enhances the diagnosis for GERD. METHODS: Patients with frequent upper gastrointestinal symptoms who had not taken a proton pump inhibitor in the previous 2 months and who had evaluable distal oesophageal biopsies were included (Diamond study: NCT00291746)...
March 20, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28314577/nanotubes-the-fast-track-to-treatment-of-dent-disease
#4
Thomas E Willnow
Studies in mice have suggested bone marrow transplantation as a strategy to correct the endocytic dysfunction of the proximal tubules in renal Fanconi syndrome, yet the mode of action has remained mysterious. Using a mouse model of Dent disease, Gabriel et al. now show that rescue of the resorptive capacity in the diseased kidney involves cell-to-cell contact between engrafted and host cells via nanotubes, cellular projections that enable transfer of wild-type activity into mutant cells of the proximal tubule...
April 2017: Kidney International
https://www.readbyqxmd.com/read/28303891/il-21-restricts-t-follicular-regulatory-t-cell-proliferation-through-bcl-6-mediated-inhibition-of-responsiveness-to-il-2
#5
Christoph Jandl, Sue M Liu, Pablo F Cañete, Joanna Warren, William E Hughes, Alexis Vogelzang, Kylie Webster, Maria E Craig, Gulbu Uzel, Alexander Dent, Polina Stepensky, Bärbel Keller, Klaus Warnatz, Jonathan Sprent, Cecile King
T follicular regulatory (Tfr) cells control the magnitude and specificity of the germinal centre reaction, but how regulation is contained to ensure generation of high-affinity antibody is unknown. Here we show that this balance is maintained by the reciprocal influence of interleukin (IL)-2 and IL-21. The number of IL-2-dependent FoxP3(+) regulatory T cells is increased in the peripheral blood of human patients with loss-of-function mutations in the IL-21 receptor (IL-21R). In mice, IL-21:IL-21R interactions influence the phenotype of T follicular cells, reducing the expression of CXCR4 and inhibiting the expansion of Tfr cells after T-cell-dependent immunization...
March 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28302290/statin-intolerance-and-risk-of-coronary-heart-events-and-all-cause-mortality-following-myocardial-infarction
#6
Maria-Corina Serban, Lisandro D Colantonio, Angelika D Manthripragada, Keri L Monda, Vera A Bittner, Maciej Banach, Ligong Chen, Lei Huang, Ricardo Dent, Shia T Kent, Paul Muntner, Robert S Rosenson
BACKGROUND: Many patients report adverse reactions to, and may not tolerate, statin therapy. These patients may be at increased risk for coronary heart disease (CHD) events and mortality. OBJECTIVES: This study evaluated the risk for recurrent myocardial infarction (MI), CHD events, and all-cause mortality in Medicare beneficiaries with statin intolerance and in those with high adherence to statin therapy. METHODS: We studied 105,329 Medicare beneficiaries who began a moderate- or high-intensity statin dosage after hospitalization for MI between 2007 and 2013...
March 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28284943/energy-efficient-electrocoagulation-using-a-new-flow-column-reactor-to-remove-nitrate-from-drinking-water-experimental-statistical-and-economic-approach
#7
Khalid S Hashim, Andy Shaw, Rafid Al Khaddar, Montserrat Ortoneda Pedrola, David Phipps
In this investigation, a new bench-scale electrocoagulation reactor (FCER) has been applied for drinking water denitrification. FCER utilises the concepts of flow column to mix and aerate the water. The water being treated flows through the perforated aluminium disks electrodes, thereby efficiently mixing and aerating the water. As a result, FCER reduces the need for external stirring and aerating devices, which until now have been widely used in the electrocoagulation reactors. Therefore, FCER could be a promising cost-effective alternative to the traditional lab-scale EC reactors...
March 9, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28282448/correction-ifn-%C3%AE-and-il-21-double-producing-t-cells-are-bcl6-independent-and-survive-into-the-memory-phase-in-plasmodium-chabaudi-infection
#8
Victor H Carpio, Michael M Opata, Marelle E Montañez, Pinaki P Banerjee, Alexander L Dent, Robin Stephens
[This corrects the article DOI: 10.1371/journal.pone.0144654.].
2017: PloS One
https://www.readbyqxmd.com/read/28272846/do-surgeons-have-a-sell-by-date
#9
D M Dent
When should surgeons retire? Do they have a defined shelf life and a sell-by date? At what point should they chuck in the scalpel and hang up their gloves? The answer to these questions for young and old surgeons is found by them merely looking around themselves: the young to make continuous mental notes about what to do (and not to do) when they get older; older surgeons to do so as a reality or insight check. The first gaze is at the theory and understanding that underpins surgery - academic surgery if you will - and the second gaze is at the craft of cutting, for surgeons are really just journeymencraftsmen, the better ones with well-developed cognitive and manipulative skills...
November 2016: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28259321/school-based-oral-hygiene-education-program-has-long-term-positive-effects-on-oral-health-indicators
#10
Helena Silveira Schuch, Loc Giang Do
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Long-term effectiveness of school-based children oral hygiene program on oral health after 10-year follow-up. Lai H, Fann JC-Y, Yen AM-F, Chen L-S, Lai M-H, Chiu SY-H. Community Dent Oral Epidemiol 2016;44(3):209-15. SOURCE OF FUNDING: Information not available TYPE OF STUDY/DESIGN: Prospective cohort design.
March 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28259318/the-use-of-adhesive-systems-under-fissure-sealants-improves-their-retention-with-etch-and-rinse-performing-better-than-self-etching-adhesive-systems
#11
Stefania Martignon, Olga Lucia Zarta
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Adhesive systems under fissure sealants: yes or no?: A systematic review and meta-analysis. Bagherian A, Shirazi AS, Sadeghi R. J Am Dent Assoc 2016;147(6):446-56. SOURCE OF FUNDING: The authors reported that no external funding sources directly supported this study TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data.
March 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28259317/some-but-not-all-psychosocial-factors-are-correlated-with-oral-hygiene-behavior-among-children-age-9-to-19%C3%A2-years
#12
Deborah E Polk
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Psychosocial correlates of oral hygiene behaviour in people aged 9 to 19 - a systematic review with meta-analysis. Scheerman JFM, van Loveren C, van Meijel B, Dusseldorp E, Wartewig E, Verrips GHW, Ket JCF, van Empelen P. Community Dent Oral Epidemiol 2016;44(4):331-41. SOURCE OF FUNDING: Information not available TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data.
March 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28259316/individuals-who-brush-their-teeth-infrequently-may-be-at-greater-risk-for-new-carious-lesions
#13
Norman Tinanoff
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Effect of Toothbrushing Frequency on Incidence and Increment of Dental Caries: A Systematic Review and Meta-Analysis. Kumar S, Tadadamadla J, Johnson NW. J Dent Res 2016;95(11):1230-6. SOURCE OF FUNDING: Information not available TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data.
March 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28259315/clinical-practice-guidelines-proposed-the-use-of-pit-and-fissure-sealants-to-prevent-and-arrest-noncavitated-carious-lesions
#14
Chris Deery
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Evidence-based clinical practice guideline for the use of pit-and-fissure sealants: A report of the American Dental Association and the American Academy of Pediatric Dentistry. Wright JT, Crall JJ, Fontana M, Gillette EJ, Nový BB, Dhar V, Donly K, Hewlett ER, Quinonez RB, Chaffin J, Crespin M, Iafolla T, Siegal MD, Tampi MP, Graham L, Estrich C, Carrasco-Labra A. J Am Dent Assoc. 2016;147(8):672-82. SOURCE OF FUNDING: American Dental Association and the American Academy of Pediatric Dentistry...
March 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28259314/self-reported-dental-anxiety-is-associated-with-both-state-anxiety-and-dental-procedure-related-pain
#15
Lisa J Heaton
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Association between anxiety and pain in dental treatment: a systematic review and meta-analysis. Lin CS, Wu SY, Yi CA. J Dent Res 2016;November 14:0022034516678168. SOURCE OF FUNDING: Ministry of Science and Technology of Taiwan (103-2314-B-010-025-MY3). TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data.
March 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28259243/a-randomized-trial-examining-the-effects-of-conjoint-behavioral-consultation-in-rural-schools-student-outcomes-and-the-mediating-role-of-the-teacher-parent-relationship
#16
Susan M Sheridan, Amanda L Witte, Shannon R Holmes, Michael J Coutts, Amy L Dent, Gina M Kunz, ChaoRong Wu
The results of a large-scale randomized controlled trial of Conjoint Behavioral Consultation (CBC) on student outcomes and teacher-parent relationships in rural schools are presented. CBC is an indirect service delivery model that addresses concerns shared by teachers and parents about students. In the present study, the intervention was aimed at promoting positive school-related social-behavioral skills and strengthening teacher-parent relationships in rural schools. Participants were 267 students in grades K-3, their parents, and 152 teachers in 45 Midwest rural schools...
April 2017: Journal of School Psychology
https://www.readbyqxmd.com/read/28258661/polymerization-mode-of-self-adhesive-dual-cured-dental-resin-cements-light-cured-through-various-restorative-materials
#17
Ji Suk Shim, Jeong Kyung Kang, Nayansi Jha, Jae Jun Ryu
OBJECTIVE: The aim of this study was to investigate the polymerization mode of self-adhesive, dual-cured resin cements light-cured through overlying materials with different degree of translucency by measuring the degree of conversion (DC). MATERIALS AND METHODS: Three kinds of self-adhesive, dual-cured resin cements (G-CEM LinkAce(TM) , Maxcem Elite(TM) , and BisCem(®) ) were light-cured through three different restorative materials that included porcelain-fused metal (PFM), zirconia, and lithium disilicate...
March 4, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28256525/magnetic-nanoparticles-a-strategy-to-target-the-choroidal-layer-in-the-posterior-segment-of-the-eye
#18
Martina Giannaccini, Lucia Pedicini, Guglielma De Matienzo, Federica Chiellini, Luciana Dente, Vittoria Raffa
Despite the higher rate of blindness due to population aging, minimally invasive and selective drug delivery to the eye still remains an open challenge, especially in the posterior segment. The retina, the retinal pigment epithelium (RPE) and the choroid are posterior segment cell layers, which may be affected by several diseases. In particular, damages to the choroid are associated with poor prognosis in the most severe pathologies. A drug delivery approach, able to target the choroid, is still missing. Recently, we demonstrated that intravitreally injected magnetic nanoparticles (MNP) are able to rapidly and persistently localise within the RPE in an autonomous manner...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28250051/systemic-autoimmunity-induced-by-the-tlr7-8-agonist-resiquimod-causes-myocarditis-and-dilated-cardiomyopathy-in-a-new-mouse-model-of-autoimmune-heart-disease
#19
Muneer G Hasham, Nicoleta Baxan, Daniel J Stuckey, Jane Branca, Bryant Perkins, Oliver Dent, Ted Duffy, Tolani S Hameed, Sarah E Stella, Mohammed Bellahcene, Michael D Schneider, Sian E Harding, Nadia Rosenthal, Susanne Sattler
Systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here, we characterise immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the Toll-like receptor 7/8 (TLR7/8) agonist Resiquimod...
March 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28249876/pooled-safety-analysis-of-evolocumab-in-over-6000-patients-from-double-blind-and-open-label-extension-studies
#20
Peter P Toth, Olivier Descamps, Jacques Genest, Naveed Sattar, David Preiss, Ricardo E Dent, Constantine S Djedjos, Yuna Wu, Michelle Geller, Magdalena Uhart, Ransi Somaratne, Scott M Wasserman
Background -Evolocumab, a fully human monoclonal antibody to PCSK9, markedly reduces LDL-C across diverse patient populations. The objective of this study was to assess the safety and tolerability of evolocumab in a pooled safety analysis from phase 2 or 3 randomized and placebo or comparator-controlled trials (integrated parent trials) and the first year of open-label extension (OLE) trials that included a standard-of-care control group. Methods -This analysis included adverse event (AE) data from 6026 patients in 12 phase 2 and 3 parent trials, with a median exposure of 2...
March 1, 2017: Circulation
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