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https://www.readbyqxmd.com/read/29165543/identification-of-older-adults-with-frailty-in-the-emergency-department-using-a-frailty-index-results-from-a-multinational-study
#1
Audrey-Anne Brousseau, Elsa Dent, Ruth Hubbard, Don Melady, Marcel Émond, Éric Mercier, Andrew P Costa
Objective: frailty is a central concept in geriatric medicine, yet its utility in the Emergency Department (ED) is not well understood nor well utilised. Our objectives were to develop an ED frailty index (FI-ED), using the Rockwood cumulative deficits model and to evaluate its association with adverse outcomes. Method: this was a large multinational prospective cohort study using data from the interRAI Multinational Emergency Department Study. The FI-ED was developed from the Canadian cohort and validated in the multinational cohort...
November 20, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29165539/management-of-musculoskeletal-conditions-in-rural-south-australia-a-randomised-controlled-trial
#2
E Dent, E Hoon, J Karnon, A Kitson, J Dollard, J Newbury, G Harvey, T Gill, J Beilby
With age, the prevalence of musculoskeletal conditions increases markedly. This rural-based study determined the benefits of two approaches for managing musculoskeletal conditions: a multiple-component 'Self-management Plus' intervention, and usual care. The intervention combined self-management education with physical activity and health professional support. 6-month outcomes included: Clinical Global Impression-Improvement Scale (CGI-IS) and Quality of Life (QoL). A total of 145 people were recruited; mean (SD) age was 66...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29164776/nutritional-screening-and-dietitian-consultation-rates-in-a-geriatric-evaluation-and-management-unit
#3
Elsa Dent, Olivia Wright, Emiel O Hoogendijk, Ruth E Hubbard
AIM: Nutritional screening may not always lead to intervention. The present study aimed to determine: (i) the rate of nutritional screening in hospitalised older adults; (ii) whether nutritional screening led to dietitian consultation and (iii) factors associated with malnutrition. METHODS: In this prospective study of patients aged ≥70 years admitted to a Geriatric Evaluation and Management Unit (GEMU), malnutrition was screened for using the Mini Nutritional Assessment Short Form (MNA-SF) and identified using the Mini Nutritional Assessment (MNA)...
November 22, 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29163826/hdac-inhibitors-enhance-neratinib-activity-and-when-combined-enhance-the-actions-of-an-anti-pd-1-immunomodulatory-antibody-in-vivo
#4
Laurence Booth, Jane L Roberts, Andrew Poklepovic, Francesca Avogadri-Connors, Richard E Cutler, Alshad S Lalani, Paul Dent
Patients whose NSCLC tumors become afatinib resistant presently have few effective therapeutic options to extend their survival. Afatinib resistant NSCLC cells were sensitive to clinically relevant concentrations of the irreversible pan-HER inhibitor neratinib, but not by the first generation ERBB1/2/4 inhibitor lapatinib. In multiple afatinib resistant NSCLC clones, HDAC inhibitors reduced the expression of ERBB1/3/4, but activated c-SRC, which resulted in higher total levels of ERBB1/3 phosphorylation. Neratinib also rapidly reduced the expression of ERBB1/2/3/4, c-MET and of mutant K-/N-RAS; K-RAS co-localized with phosphorylated ATG13 and with cathepsin B in vesicles...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163523/interleukin-5-mediates-parasite-induced-protection-against-experimental-autoimmune-encephalomyelitis-association-with-induction-of-antigen-specific-cd4-cd25-t-regulatory-cells
#5
Giang T Tran, Paul L Wilcox, Lindsay A Dent, Catherine M Robinson, Nicole Carter, Nirupama D Verma, Bruce M Hall, Suzanne J Hodgkinson
Objective: To examine if the protective effect of parasite infection on experimental autoimmune encephalomyelitis (EAE) was due to interleukin (IL)-5, a cytokine produced by a type-2 response that induces eosinophilia. We hypothesize that, in parasite infections, IL-5 also promotes expansion of antigen-specific T regulatory cells that control autoimmunity. Methods: Nippostrongylus brasiliensis larvae were used to infect Lewis rats prior to induction of EAE by myelin basic protein...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29161805/robot-assisted-radical-cystectomy-with-totally-intracorporeal-urinary-diversion-initial-single-surgeon-s-experience-after-a-modified-modular-training
#6
Angelo Porreca, Francesco Chessa, Daniele Romagnoli, Antonio Salvaggio, Angelo Cafarelli, Marco Borghesi, Lorenzo Bianchi, Matteo Dandrea, Daniele D'Agostino, Donato Dente, Emanuele Cappa, Peter Wiklund, Eugenio Brunocilla, Riccardo Schiavina
BACKGROUND: To report the perioperative and early functional outcomes of patients undergoing Robot-assisted radical cystectomy (RARC) with totally intracorporeal urinary diversion performed by a single surgeon after a modified modular training. METHODS: The surgeon (A.P.) attained a 30-days modified modular training at a referring Centre mentored by a worldwide-recognized robotic surgeon (P.W.). The training program consisted of: a) e-learning based on 10 hours of theoretical lessons made by the mentor; b) video-session concerning the different steps of the procedure, c) step-by-step in vivo modular training...
November 21, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29151592/diet-resistant-obesity-is-characterized-by-a-distinct-plasma-proteomic-signature-and-impaired-muscle-fiber-metabolism
#7
A B Thrush, G Antoun, M Nikpay, D A Patten, C DeVlugt, J-F Mauger, B L Beauchamp, P Lau, R Reshke, É Doucet, P Imbeault, R Boushel, D Gibbings, J Hager, A Valsesia, R Slack, O Y Al-Dirbashi, R Dent, R McPherson, M-E Harper
BACKGROUND/OBJECT: Inter-individual variability in weight loss during obesity treatment is complex and poorly understood. Here we use whole body and tissue approaches to investigate fuel oxidation characteristics in skeletal muscle fibers, cells, and distinct circulating protein biomarkers before and after a high fat meal (HFM) challenge in those who lost the most (obese diet-sensitive; ODS), vs the least (obese diet-resistant; ODR) amount of weight in a highly controlled weight management program...
November 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29148982/a-dentin-derived-hydrogel-bioink-for-3d-printing-of-cell-laden-scaffolds-for-regenerative-dentistry
#8
Avathamsa Athirasala, Anthony Tahayeri, Greeshma Thrivikraman, Cristiane Miranda Franca, Nelson Monteiro, Victor Tran, Jack Ferracane, Luiz Bertassoni
Recent studies in tissue engineering have adopted extracellular matrix (ECM) derived scaffolds as natural and cytocompatible microenvironments for tissue regeneration. The dentin matrix, specifically, has been shown to be associated with a host of soluble and insoluble signaling molecules that can promote odontogenesis. Here, we have developed a novel bioink, blending printable alginate (3% w/v) hydrogels with the soluble and insoluble fractions of the dentin matrix. We have optimized the printing parameters and the concentrations of the individual components of the bioink for print accuracy, cell viability and odontogenic potential...
November 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/29137723/the-promise-and-problems-of-non-physician-practitioners-in-general-surgery-education-results-of-a-multi-center-mixed-methods-study-of-faculty
#9
James E Coverdill, Jeff Scott Shelton, Adnan Alseidi, David C Borgstrom, Daniel L Dent, Russell Dumire, Jonathan Fryer, Thomas H Hartranft, Steven B Holsten, M Timothy Nelson, Mohsen M Shabahang, Stanley R Sherman, Paula M Termuhlen, Randy J Woods, John D Mellinger
BACKGROUND: Nurse Practitioners and Physician Assistants - called non-physician practitioners or NPPs - are common, but little is known about their educational promise and problems. METHODS: General surgery faculty in 13 residency programs were surveyed (N = 279 with a 71% response rate) and interviewed (N = 43) about experiences with NPPs. The survey documents overall patterns and differences by program type and primary service; interviews point to deeper rationales and concerns...
November 5, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29137331/hdac-inhibitors-enhance-the-immunotherapy-response-of-melanoma-cells
#10
Laurence Booth, Jane L Roberts, Andrew Poklepovic, John Kirkwood, Paul Dent
We focused on the ability of the pan-histone deacetylase (HDAC) inhibitors AR42 and sodium valproate to alter the immunogenicity of melanoma cells. Treatment of melanoma cells with HDAC inhibitors rapidly reduced the expression of multiple HDAC proteins as well as the levels of PD-L1, PD-L2 and ODC, and increased expression of MHCA. In a cell-specific fashion, melanoma isolates released the immunogenic protein HMGB1 into the extracellular environment. Very similar data were obtained in ovarian and H&NSCC PDX isolates, and in established tumor cell lines from the lung and kidney...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132645/assessing-the-16-hour-intern-shift-limit-results-of-a-multi-center-mixed-methods-study-of-residents-and-faculty-in-general-surgery
#11
James E Coverdill, Adnan Alseidi, David C Borgstrom, Daniel L Dent, Russell Dumire, Jonathan Fryer, Thomas H Hartranft, Steven B Holsten, M Timothy Nelson, Mohsen M Shabahang, Stanley R Sherman, Paula M Termuhlen, Randy J Woods, John D Mellinger
BACKGROUND: The study explores how residents and faculty assess the ACGME's 16-h limit on intern shifts. METHODS: Questionnaire response rates were 76% for residents (N = 291) and 71% for faculty (N = 279) in 13 general surgery residency programs. Results include means, percentage in agreement, and statistical tests for 15 questionnaire items. Semi-structured interviews conducted with 39 residents and 43 faculty were analyzed for main themes. RESULTS: Few view the intern shift limit as a positive change...
November 4, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29118716/etiology-and-recovery-of-neuromuscular-fatigue-following-competitive-soccer-match-play
#12
Callum G Brownstein, Jack P Dent, Paul Parker, Kirsty M Hicks, Glyn Howatson, Stuart Goodall, Kevin Thomas
Aim: Previous research into the etiology of neuromuscular fatigue following competitive soccer match-play has primarily focused on peripheral perturbations, with limited research assessing central nervous system function in the days post-match. The aim of the present study was to examine the contribution and time-course of recovery of central and peripheral factors toward neuromuscular fatigue following competitive soccer match-play. Methods: Sixteen male semi-professional soccer players completed a 90-min soccer match...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29115720/pathological-outcomes-in-rectal-cancer-following-laparoscopic-surgery
#13
Henry Yan Chi Cheung, Owen F Dent, Gillian L Richardson, Charles Chan, Anil Keshava, Christopher J Young
AIM: This study examined pathological quality-of-surgery indicators in laparoscopic and open rectal cancer resection specimens. METHODS: Retrospective analysis of consecutive, prospectively recorded laparoscopic (LR) or open (OR) resections for rectal cancer. Indicators included integrity of the perirectal fascial envelope, circumferential margin clearance, lymph node yield and distal margin clearance. RESULTS: Between January 2007 and December 2013, 168 LR and 189 OR were performed...
November 8, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29111103/muscle-specific-knockout-of-general-control-of-amino-acid-synthesis-5-gcn5-does-not-enhance-basal-or-endurance-exercise-induced-mitochondrial-adaptation
#14
Jessica R Dent, Vitor F Martins, Kristoffer Svensson, Samuel A LaBarge, Noah C Schlenk, Mary C Esparza, Elisa H Buckner, Gretchen A Meyer, D Lee Hamilton, Simon Schenk, Andrew Philp
OBJECTIVE: Lysine acetylation is an important post-translational modification that regulates metabolic function in skeletal muscle. The acetyltransferase, general control of amino acid synthesis 5 (GCN5), has been proposed as a regulator of mitochondrial biogenesis via its inhibitory action on peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α). However, the specific contribution of GCN5 to skeletal muscle metabolism and mitochondrial adaptations to endurance exercise in vivo remain to be defined...
October 16, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29105509/the-role-of-feature-based-discrimination-in-driving-health-disparities-among-black-americans
#15
Randl B Dent, Nao Hagiwara, Elena V Stepanova, Tiffany L Green
OBJECTIVE: A growing body of research finds that darker skin tone is often associated with poorer physical and mental health in Blacks. However, the psychosocial mechanisms underlying the skin tone-health link remain elusive. The present study seeks to address this knowledge gap by investigating the direct and indirect (through perceived discrimination, socioeconomic status, and self-esteem) effects of skin tone on self-reported physical and mental health. DESIGN: An urban sample of 130 Blacks aged 35 and above completed a self-administered computerized survey as a part of larger cross-sectional study...
November 6, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29104396/treatment-of-maxillary-impacted-canine-using-ballista-spring-and-orthodontic-wire-traction
#16
Pradeep Raghav, Kanika Singh, C Munish Reddy, Divya Joshi, Shalu Jain
In orthodontic practice, impaction of maxillary permanent canines is a frequently encountered clinical problem. After the third molar, the canine is the most frequently impacted tooth. For functional occlusion, bringing the impacted canine into occlusion is important to achieve final esthetic in orthodontic practice. This article illustrates a distinct case in which the three permanent canines maintained their unerupted status till the age of 18 years. The three impacted canines were surgically exposed, attachment bonded, traction given with ballista spring for vertical and labial movement, and ideally positioned with fixed orthodontic mechanotherapy...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29104395/primary-maxillary-bilateral-central-incisors-with-two-roots
#17
Shweta S Jajoo
A rare case of birooted primary maxillary central incisor is reported. A 5-year-old male patient reported with carious maxillary primary anterior teeth. Radiographic examination incidentally revealed root bifurcation in primary maxillary central incisors bilaterally. This represents a rare finding. There are few cases that have reported birooted permanent incisors, but there is no case reported till date with birooted primary incisors. This report discusses the findings in the context of the available literature...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29104394/functional-lingual-arch-with-hinge-type-lockable-dentulous-component
#18
Paul Chalakkal, Amanda N Ferreira, Godwin C Da Costa, Meena A Aras
The conventional lingual arch is a nonfunctional fixed space maintainer used in the mandibular arch to maintain arch length by the prevention of mesial movement of the permanent first molars. This study highlights a functional lingual arch with a hinge-type lockable dentulous component that incorporates molar tubes, with various advantages over the conventional lingual arch. How to cite this article: Chalakkal P, Ferreira AN, Da Costa GC, Aras MA. Functional Lingual Arch with Hinge-type Lockable Dentulous Component...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29104393/distalization-of-maxillary-first-permanent-molar-by-pendulum-appliance-in-mixed-dentition-period
#19
Sujatha Paranna, Prakashchandra Shetty, Latha Anandakrishna, Anuradha Rawat
Introduction: Mesial drifting of molar teeth in maxillary arch is corrected by movement of the molars distally. In addition to traditional distal movement techniques, such as extraoral force application and removable appliances, various intra-arch devices have been introduced since 1980s. These intra-arch appliances have nearly eliminated the need for patient cooperation. Case report: The purpose of this paper is to report a case of 10-year-old male patient with loss of space in maxillary molar teeth treated by intra-arch appliance-pendulum appliance by distalization of maxillary first permanent molar teeth...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29104392/association-between-fever-and-primary-tooth-eruption-a-systematic-review-and-meta-analysis
#20
REVIEW
Mariana A Nemezio, Katharina Mh De Oliveira, Priscilla C Romualdo, Alexandra M Queiroz, Francisco Wg Paula-E-Silva, Raquel Ab Silva, Erika C Küchler
Aim: To perform a systematic review and meta-analysis to establish if fever is associated with primary tooth eruption. Materials and methods: Literature searches involved Pubmed, MEDLINE, Web of Science, Scopus and Cochrane. The potentially relevant studies had the full text analyzed. Only studies concerning fever during eruption period of primary tooth in humans were included. Papers in non-English language, and papers that included syndromic patients or patients with any disease were excluded...
July 2017: International Journal of Clinical Pediatric Dentistry
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