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https://www.readbyqxmd.com/read/27885830/extended-dual-antiplatelet-therapy-after-acute-coronary-syndrome-in-spain-results-from-the-epicor-study
#1
Alfredo Bardají, Manuel Leal, Vicente Arrarte, Xavier Garcia-Moll, Leopoldo Pérez de Isla, Héctor Bueno
INTRODUCTION: Real-world, country-specific studies of dual antiplatelet therapy (DAPT) duration among survivors of acute coronary syndrome (ACS) are important for improving long-term prognosis. AIMS: To investigate DAPT duration after hospital discharge for ACS in Spain. RESULTS: Data from patients enrolled in the Spanish cohort of the EPICOR (long-tErm follow-up of antithrombotic management Patterns In acute CORonary syndrome patients) study (NCT01171404) were analyzed for changes to antithrombotic medication up to 2 years post-discharge according to index event diagnosis and patient characteristics...
November 25, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27824951/epigenetic-signatures-at-aqp3-and-socs3-engage-in-low-grade-inflammation-across-different-tissues
#2
Carola Marzi, Lesca M Holdt, Giovanni Fiorito, Pei-Chien Tsai, Anja Kretschmer, Simone Wahl, Simonetta Guarrera, Daniel Teupser, Tim D Spector, Licia Iacoviello, Carlotta Sacerdote, Konstantin Strauch, Serene Lee, Wolfgang E Thasler, Annette Peters, Barbara Thorand, Petra Wolf, Holger Prokisch, Rosario Tumino, Christian Gieger, Vittorio Krogh, Salvatore Panico, Jordana T Bell, Giuseppe Matullo, Melanie Waldenberger, Harald Grallert, Wolfgang Koenig
BACKGROUND: Elevated levels of C-reactive protein (CRP, determined by a high-sensitivity assay) indicate low-grade inflammation which is implicated in many age-related disorders. Epigenetic studies on CRP might discover molecular mechanisms underlying CRP regulation. We aimed to identify DNA methylation sites related to CRP concentrations in cells and tissues regulating low-grade inflammation. RESULTS: Genome-wide DNA methylation was measured in peripheral blood in 1,741 participants of the KORA F4 study using Illumina HumanMethylation450 BeadChip arrays...
2016: PloS One
https://www.readbyqxmd.com/read/27711245/the-association-between-educational-level-and-cardiovascular-and-cerebrovascular-diseases-within-the-epicor-study-new-evidence-for-an-old-inequality-problem
#3
Fulvio Ricceri, Carlotta Sacerdote, Maria Teresa Giraudo, Francesca Fasanelli, Giulia Lenzo, Matteo Galli, Sabina Sieri, Valeria Pala, Giovanna Masala, Benedetta Bendinelli, Rosario Tumino, Graziella Frasca, Paolo Chiodini, Amalia Mattiello, Salvatore Panico
BACKGROUND: A consistent association has been reported between low socioeconomic status (SES) and cardiovascular events (CE), whereas the association between SES and cerebrovascular events (CBVD) is less clear. The aim of this study was to investigate the association between SES (measured using education) and CE/CBVD in a cohort study, as well as to investigate lifestyle and clinical risk factors, to help to clarify the mechanisms by which SES influences CE/CBVD. MATERIAL AND METHODS: We searched for diagnoses of CE and CBVD in the clinical records of 47,749 members of the EPICOR cohort (average follow-up time: 11 years)...
2016: PloS One
https://www.readbyqxmd.com/read/27504002/international-patterns-of-dual-antiplatelet-therapy-duration-after-acute-coronary-syndromes
#4
Héctor Bueno, Stuart Pocock, Nicolas Danchin, Lieven Annemans, John Gregson, Jesús Medina, Frans Van de Werf
OBJECTIVE: To describe international patterns of dual antiplatelet therapy (DAPT) duration after acute coronary syndrome (ACS), and explore its determinants and correlation with clinical events. METHODS: EPICOR (long-tErm follow-uP of anti-thrombotic management patterns In acute CORonary syndrome patients) is a prospective, international, observational study of 10 568 ACS hospital survivors enrolled in 555 centres from 20 countries across Europe and Latin America between 2010 and 2011, with telephone follow-up at quarterly intervals up to 24 months to assess treatment continuation and clinical events...
August 8, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27503713/mitigation-of-heat-stress-related-complications-by-a-yeast-fermentate-product
#5
Henri Alexandre Giblot Ducray, Ludmila Globa, Oleg Pustovyy, Stuart Reeves, Larry Robinson, Vitaly Vodyanoy, Iryna Sorokulova
Heat stress results in a multitude of biological and physiological responses which can become lethal if not properly managed. It has been shown that heat stress causes significant adverse effects in both human and animals. Different approaches have been proposed to mitigate the adverse effects caused by heat stress, among which are special diet and probiotics. We characterized the effect of the yeast fermentate EpiCor (EH) on the prevention of heat stress-related complications in rats. We found that increasing the body temperature of animals from 37...
August 2016: Journal of Thermal Biology
https://www.readbyqxmd.com/read/27443472/pre-and-in-hospital-antithrombotic-management-patterns-and-in-hospital-outcomes-in-patients-with-acute-coronary-syndrome-data-from-the-turkish-arm-of-the-epicor-study
#6
Fatih Sinan Ertaş, Lale Tokgözoğlu
OBJECTIVE: To evaluate the acute phase (pre- and in-hospital) antithrombotic management patterns (AMPs) and in-hospital outcomes for patients hospitalized with an acute coronary syndrome (ACS). METHODS: In total, 1034 patients [514 patients with ST-segment elevation myocardial infarction (STEMI) and 520 with unstable angina/non-STEMI (UA/NSTEMI)] hospitalized for ACS within 24 h of symptom onset were included in this multicenter prospective registry study conducted at 34 hospitals across Turkey...
June 29, 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27303240/primary-cardiac-sarcoidosis-with-syncope-and-refractory-atrial-arrhythmia-a-case-report-and-review-of-the-literature
#7
Manoj Thangam, Sriram Nathan, Biswajit Kar, Marija Petrovic, Manish Patel, Pranav Loyalka, L Maximilian Buja, Igor D Gregoric
We discuss the case of a 38-year-old black man who presented at our hospital with his first episode of syncope, recently developed atrial arrhythmias refractory to pharmacologic therapy, and a left atrial thrombus. He was diagnosed with primary cardiac sarcoidosis characterized by predominant involvement of the epicardium that caused atrial fibrillation and atrial flutter. Histologic analysis of his epicardial lesions yielded a diagnosis of sarcoidosis. This patient's atrial arrhythmia was successfully treated with a hybrid operation that involved resection of his atrial appendage, an Epicor maze procedure, and radiofrequency ablation during a catheter-based electrophysiologic study...
June 2016: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/27127635/prehospital-and-in-hospital-use-of-healthcare-resources-in-patients-surviving-acute-coronary-syndromes-an-analysis-of-the-epicor-registry
#8
Lieven Annemans, Nicolas Danchin, Frans Van de Werf, Stuart Pocock, Muriel Licour, Jesús Medina, Héctor Bueno
OBJECTIVE: The aim of this report is to provide insight into real-world healthcare resource use (HCRU) during the critical management of patients surviving acute coronary syndromes (ACS), using data from EPICOR (long-tErm follow-up of antithrombotic management Patterns In acute CORonary syndrome patients) (NCT01171404). METHODS: EPICOR was a prospective, multinational, observational study that enrolled 10 568 ACS survivors from 555 hospitals in 20 countries in Europe and Latin America, between September 2010 and March 2011...
2016: Open Heart
https://www.readbyqxmd.com/read/26617014/beta-glucan-depleted-glycopeptide-rich-extracts-from-brewer-s-and-baker-s-yeast-saccharomyces-cerevisiae-lower-interferon-gamma-production-by-stimulated-human-blood-cells-in-vitro
#9
Roderick Williams, Daniel A Dias, Nirupama Jayasinghe, Ute Roessner, Louise E Bennett
Regulation of the human immune system requires controlled pro- and anti-inflammatory responses for host defence against infection and disease states. Yeasts (Saccharomyces cerevisiae), as used in brewing and baking, are mostly known for ability to stimulate the human immune-system predominantly reflecting the pro-inflammatory cell wall β-glucans. However, in this study, using food-compatible processing methods, glycopeptide-enriched and β-glucan-depleted products were each prepared from Brewer's and Baker's yeasts, which suppressed production of interferon-γ (IFN-γ) in human whole blood cell assay, signifying that anti-inflammatory factors are also present in yeast...
April 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26554684/-dietary-habits-and-cardiovascular-disease-the-experience-of-epic-italian-collaboration
#10
Amalia Mattiello, Paolo Chiodini, Maria Santucci de Magistris, Vittorio Krogh, Sara Grioni, Francesca Fasanelli, Paolo Vineis, Calogero Saieva, Benedetta Bendinelli, Graziella Frasca, Maria Concetta Giurdanella, Salvatore Panico
OBJECTIVES: to report and evaluate the evidence produced by the EPIC Italian collaboration (EPICOR Project) on the dietary determinants of cardiovascular diseases in Italy. DESIGN: prospective study carried out in a large Italian population, composed by cohorts recruited in Northern, Central and Southern Italy. SETTING AND PARTICIPANTS: data on dietary habits collected at the baseline observation through standardised questionnaires on 47,749 free-living adults at the time of the recruitment of the study (1993-1998)...
September 2015: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/26206158/rationale-design-and-baseline-characteristics-of-the-epicor-asia-study-long-term-follow-up-of-antithrombotic-management-patterns-in-acute-coronary-syndrome-patients-in-asia
#11
MULTICENTER STUDY
Yong Huo, Stephen W-L Lee, Jitendra P S Sawhney, Hyo-Soo Kim, Rungroj Krittayaphong, Vo T Nhan, Angeles Alonso-Garcia, Ya Ling Han, Junbo Ge, Chee Tang Chin, Tiong K Ong, Stephen Jan, Yohji Itoh, Ana Maria Vega, Stuart Pocock
BACKGROUND: In-hospital and postdischarge mortality for acute coronary syndromes (ACS) vary across Asia and remain generally poorer than globally. The relationship between real-life antithrombotic management patterns (AMPs) and ACS-related outcomes in Asia is unclear. METHODS: EPICOR Asia (Long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) (NCT01361386) is a prospective, multinational, observational study of patients discharged after hospitalization for an ACS, with 2-year follow-up...
September 2015: Clinical Cardiology
https://www.readbyqxmd.com/read/26006216/high-intensity-focused-ultrasound-ablation-for-atrial-fibrillation-results-from-the-national-spanish-registry
#12
Guillermo Reyes, Xavier Ruyra, Francisco Valderrama, Antonio Jimenez, Dario Duran, Enrique Perez, Tomas Daroca, Javier Moya, Ulises Ramirez, Gonzalo Aldamiz
BACKGROUND: A National Spanish Registry to compile all patients treated with high intensity focused ultrasound (HIFU) energy for atrial fibrillation (AF) was created to evaluate the safety and efficacy of AF surgical ablation. METHODS: A national Spanish registry was created, and ten hospitals using HIFU to ablate AF joined it. A total of 412 patients undergoing cardiac surgery between 2006 and February 2013 were included. AF was divided between paroxysmal AF (33%) and persistent AF (67%) with a mean AF duration of 29...
October 2016: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/25946046/espresso-coffee-consumption-and-risk-of-coronary-heart-disease-in-a-large-italian-cohort
#13
Sara Grioni, Claudia Agnoli, Sabina Sieri, Valeria Pala, Fulvio Ricceri, Giovanna Masala, Calogero Saieva, Salvatore Panico, Amalia Mattiello, Paolo Chiodini, Rosario Tumino, Graziella Frasca, Licia Iacoviello, Amalia de Curtis, Paolo Vineis, Vittorio Krogh
BACKGROUND: The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. METHODS: We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids...
2015: PloS One
https://www.readbyqxmd.com/read/25931463/circulating-tissue-factor-levels-and-risk-of-stroke-findings-from-the-epicor-study
#14
RANDOMIZED CONTROLLED TRIAL
Licia Iacoviello, Augusto Di Castelnuovo, Amalia de Curtis, Claudia Agnoli, Graziella Frasca, Amalia Mattiello, Giuseppe Matullo, Fulvio Ricceri, Carlotta Sacerdote, Sara Grioni, Rosario Tumino, Emanuela Napoleone, Roberto Lorenzet, Giovanni de Gaetano, Salvatore Panico, Maria Benedetta Donati
BACKGROUND AND PURPOSE: Tissue factor (TF) expression is increased in inflammatory atherosclerotic plaques and has been related to their thrombogenicity. Blood-borne TF has been also demonstrated to contribute to thrombogenesis. However, few studies have evaluated the association of circulating levels of TF with stroke. We investigated the association of baseline circulating levels of TF with stroke events occurred in the European Prospective Investigation into Cancer and Nutrition-Italy cohort...
June 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/25561688/opportunities-for-improvement-in-anti-thrombotic-therapy-and-other-strategies-for-the-management-of-acute-coronary-syndromes-insights-from-epicor-an-international-study-of-current-practice-patterns
#15
Héctor Bueno, Peter Sinnaeve, Lieven Annemans, Nicolas Danchin, Muriel Licour, Jesús Medina, Stuart Pocock, Joaquín Sánchez-Covisa, Robert F Storey, J Wouter Jukema, Uwe Zeymer, Frans Van de Werf
AIMS: To describe international patterns and opportunities for improvement of pre- and in-hospital care of patients hospitalized for acute coronary syndromes (ACS), with special focus on anti-thrombotic therapy. METHODS AND RESULTS: EPICOR (long-tErm follow-uP of anti-thrombotic management patterns In acute CORonary syndrome patients), an international, cohort study, which enrolled 10,568 consecutive ACS survivors from 555 hospitals in 20 countries across Europe and Latin America (September 2010 to March 2011), prospectively registered detailed information on pre- and in-hospital management...
February 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/25381645/electrophysiological-study-6-months-after-epicor%C3%A2-high-intensity-focused-ultrasound-atrial-fibrillation-ablation
#16
Rodrigue Garcia, Frédéric Sacher, Pierre Oses, Nicolas Derval, Laurent Barandon, Arnaud Denis, Mélèze Hocini, Xavier Roques, Michel Haïssaguerre, Louis Labrousse, Pierre Jaïs
PURPOSE: Little is presently known about the outcome of atrial lesions performed with high-intensity focused ultrasound (HIFU) for atrial fibrillation ablation. We aimed to assess endocardial atrial lesions 6 months after epicardial HIFU ablation (Epicor(™)) and to evaluate the benefit of a combined ablation approach. METHODS: Thirty patients (21 males, mean age 68 ± 12 years old) undergoing HIFU atrial fibrillation ablation during cardiac surgery were enrolled...
December 2014: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/25374386/guideline-adherent-therapy-in-patients-with-acute-coronary-syndromes-the-epicor-registry-in-germany
#17
U Zeymer, H Heuer, P Schwimmbeck, S Genth-Zotz, K Wolff, C A Nienaber
BACKGROUND: Representative data on the current management of patients with acute coronary syndromes (ACS) are of high interest. The EPICOR registry aimed to prospectively collect such real-life data with particular focus on antithrombotic drug utilization and outcomes. METHODS: As part of the international prospective EPICOR registry, 29 hospitals in Germany documented 296 patients with ST-elevation myocardial infarction (STEMI)-ACS and 333 with unstable angina or non-STEMI (NSTEMI)-ACS surviving the hospital phase...
March 2015: Herz
https://www.readbyqxmd.com/read/25301783/predictors-of-one-year-mortality-at-hospital-discharge-after-acute-coronary-syndromes-a-new-risk-score-from-the-epicor-long-term-follow-up-of-antithrombotic-management-patterns-in-acute-coronary-syndrome-patients-study
#18
Stuart Pocock, Héctor Bueno, Muriel Licour, Jesús Medina, Lin Zhang, Lieven Annemans, Nicholas Danchin, Yong Huo, Frans Van de Werf
AIMS: A reliable prediction tool is needed to identify acute coronary syndrome (ACS) patients with high mortality risk after their initial hospitalization. METHODS: EPICOR (long-tErm follow uP of antithrombotic management patterns In acute CORonary syndrome patients: NCT01171404) is a prospective cohort study of 10,568 consecutive hospital survivors after an ACS event (4943 ST-segment elevation myocardial infarction (STEMI) and 5625 non-ST-elevation ACS (NSTE-ACS))...
December 2015: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/25210075/contemporary-inter-hospital-transfer-patterns-for-the-management-of-acute-coronary-syndrome-patients-findings-from-the-epicor-study
#19
Peter R Sinnaeve, Uwe Zeymer, Héctor Bueno, Nicolas Danchin, Jesús Medina, Joaquín Sánchez-Covisa, Muriel Licour, Lieven Annemans, J Wouter Jukema, Stuart Pocock, Robert F Storey, Frans Van de Werf
AIM: The EPICOR observational study was designed to describe antithrombotic strategies in a broad acute coronary syndrome (ACS) population; it also included information on inter-hospital transfers and institutional resources. METHODS AND RESULTS: EPICOR enrolled 10,568 consecutively discharged patients with ST-elevation (STE) or non-STE (NSTE) ACS in 555 centres in 20 countries across Europe and Latin America. Patients were categorized as non-transferred, transferred in from another hospital and then discharged, or transferred out to a second hospital but discharged from their initial hospital after transfer back...
June 2015: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/25105458/anti-inflammatory-properties-of-a-dried-fermentate-in-vitro-and-in-vivo
#20
Gitte S Jensen, Steve G Carter, Stuart G Reeves, Larry E Robinson, Kathleen F Benson
The aim of this study was to document anti-inflammatory properties of a dried fermentate derived from Saccharomyces cerevisiae (EpiCor(®)), hereafter referred to as dried fermentate in vitro using cell-based bioassays, and in vivo using a skin irritation model in healthy humans. In vitro testing involved parallel assessment of primary human polymorphonuclear (PMN) cell formation of reactive oxygen species (ROS) and migration toward the inflammatory mediator Leukotriene B4. In vivo evaluation used a single-blind placebo-controlled design, where dermal histamine-induced inflammation was used as a model for the complex intercellular signals involved in the initiation, escalation, and resolution of the inflammatory response...
March 2015: Journal of Medicinal Food
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