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https://www.readbyqxmd.com/read/29330025/the-role-of-extracellular-and-intracellular-nicotinamide-phosphoribosyl-transferase-in-cancer-diagnostic-and-therapeutic-perspectives-and-challenges
#1
REVIEW
Maria Dalamaga, Gerasimos Socrates Christodoulatos, Christos S Mantzoros
Nicotinamide phosphoribosyl-transferase (Nampt) or pre-B cell colony-enhancing factor or visfatin represents a pleiotropic molecule acting as an enzyme, a cytokine and a growth factor. Intracellular Nampt plays an important role in cellular bioenergetics and metabolism, particularly NAD biosynthesis. NAD biosynthesis is critical in DNA repair, oncogenic signal transduction, transcription, genomic integrity and apoptosis. Although its insulin-mimetic function remains a controversial issue, extracellular Nampt presents proliferative, anti-apoptotic, pro-inflammatory, pro-angiogenic and metastatic properties...
January 9, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29317174/elective-endoscopic-variceal-ligation-is-not-a-risk-factor-for-bacterial-infection-in-patients-with-liver-cirrhosis
#2
Sergio Maimone, Francesca Saffioti, Roberto Filomia, Gaia Caccamo, Carlo Saitta, Socrate Pallio, Pierluigi Consolo, Sara Sabatini, Krizia Sitajolo, Maria Stella Franzè, Irene Cacciola, Giovanni Raimondo, Giovanni Squadrito
BACKGROUND: Patients with cirrhosis are at high risk of bacterial infections. Invasive procedures are generally believed to increase this susceptibility. AIMS: We investigated the incidence of bacterial infections in cirrhotic patients undergoing elective endoscopic variceal ligation (EVL). METHODS: We enrolled 60 consecutive cirrhotic patients who underwent a total number of 112 elective EVL procedures. One to seven bands were applied at each session until variceal eradication...
December 20, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29306880/knowledge-opinions-and-compliance-related-to-the-100-smoke-free-law-in-hospitality-venues-in-kampala-uganda-cross-sectional-results-from-the-komply-project
#3
Shannon Gravely, Kellen Namusisi Nyamurungi, Steven Ndugwa Kabwama, Gabriel Okello, Lindsay Robertson, Kelvin Khow Chuan Heng, Achiri Elvis Ndikum, Adeniyi Samuel Oginni, Jean Christophe Rusatira, Socrates Kakoulides, Mark D Huffman, Salim Yusuf, Eduardo Bianco
OBJECTIVE: This study evaluated knowledge, opinions and compliance related to Uganda's comprehensive smoke-free law among hospitality venues in Kampala Uganda. DESIGN: This multi-method study presents cross-sectional findings of the extent of compliance in the early phase of Uganda's comprehensive smoke-free law (2 months postimplementation; pre-enforcement). SETTING: Bars, pubs and restaurants in Kampala Uganda. PROCEDURE AND PARTICIPANTS: A two-stage stratified cluster sampling procedure was used to select hospitality sites stratified by all five divisions in Kampala...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29299892/cytomegalovirus-infection-after-renal-transplantation-occurrence-clinical-features-and-the-cutoff-for-antigenemia-in-a-university-hospital-in-brazil
#4
Sócrates Bezerra de Matos, Roberto Meyer, Fernanda Washington de Mendonça Lima
BACKGROUND: Cytomegalovirus (CMV) is the main infectious agent causative of morbidity and mortality in transplant recipients. This study aimed to describe the occurrence and clinical features of CMV infection, and the optimum antigenemia assay cutoff associated with symptomatic infection. MATERIALS AND METHODS: This was a cohort study that investigated 87 patients undergoing renal transplantation. The patients were monitored with the CMV antigenemia assay performed weekly for the first 3 months post-transplantation and subsequently, when CMV infection was suspected clinically...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29261521/quantitative-analysis-of-intraventricular-flow-energetics-and-vortex-in-ischaemic-hearts
#5
Bee Ting Chan, Hak Koon Yeoh, Yih Miin Liew, Socrates Dokos, Amr Al Abed, Kok Han Chee, Yang F Abdul Aziz, Ganiga Srinivasaiah Sridhar, Karuthan Chinna, Einly Lim
OBJECTIVE: This study investigated the intraventricular flow dynamics in ischaemic heart disease patients. PATIENTS AND METHODS: Fourteen patients with normal ejection fraction and 16 patients with reduced ejection fraction were compared with 20 healthy individuals. Phase-contrast MRI was used to assess intraventricular flow variables and speckle-tracking echocardiography to assess myocardial strain and left ventricular (LV) dyssynchrony. Infarct size was acquired using delayed-enhancement MRI...
December 19, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29249867/reflection-a-socratic-approach
#6
Inge C M Van Seggelen-Damen, René Van Hezewijk, Anne S Helsdingen, Iwan G J H Wopereis
Reflection is a fuzzy concept. In this article we reveal the paradoxes involved in studying the nature of reflection. Whereas some scholars emphasize its discursive nature, we go further and underline its resemblance to the self-biased dialogue Socrates had with the slave in Plato's Meno. The individual and internal nature of the reflection process creates difficulty for studying it validly and reliably. We focus on methodological issues and use Hans Linschoten's view of coupled systems to identify, analyze, and interpret empirical research on reflection...
December 2017: Theory & Psychology
https://www.readbyqxmd.com/read/29234424/anxiolytic-effect-of-citrus-aurantium-l-in-crack-users
#7
Gabriel Chaves Neto, João Euclides Fernandes Braga, Mateus Feitosa Alves, Liana Clébia de Morais Pordeus, Sócrates Golzio Dos Santos, Marcus Tullius Scotti, Reinaldo N Almeida, Margareth de Fátima Formiga Melo Diniz
The objective of this study was to investigate the anxiolytic effects of the essential oil (EO) of Citrus aurantium L. in patients experiencing crack withdrawal. This was developed with internal users in therapeutic communities in Paraíba, Brazil. The test population consisted of 51 volunteers, subdivided into three groups. To elicit anxiety, the Simulated Public Speaking (SPS) method was used. Physiological measures were assessed at specific phases during the experiment using appropriate equipment. Psychological measures of anxiety were assessed using the Trait-State Anxiety Inventory (IDATE) and the Analog Smoke Scale (HAS)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233308/evaluation-of-students-perceptions-of-the-socrative-application-versus-a-traditional-student-response-system-and-its-impact-on-classroom-engagement
#8
Anthony J Guarascio, Branden D Nemecek, David E Zimmerman
BACKGROUND AND PURPOSE: Student response systems (SRSs) or "clickers" are common tools that lecturers can implement into didactic lectures. Socrative is a convenient and free SRS application that can be downloaded on personal handheld devices and used by faculty and students. It is unknown if students prefer using this application and what advantages or disadvantages can be seen with Socrative's use. PURPOSE: To measure student preference of standard SRS methods compared to Socrative as well as the impact of Socrative use on student engagement during delivery of clinical pharmacy instruction EDUCATIONAL ACTIVITY AND SETTING: Standard SRS and Socrative incorporated lectures were presented to students during an infectious disease module...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29230581/a-new-species-of-eimeria-schneider-1875-from-the-serra-dos-%C3%A3-rg%C3%A3-os-national-park-rio-de-janeiro-brazil-with-notes-on-its-endogenous-development-in-the-montane-grass-mouse-akodon-montensis-thomas-1913-rodentia-sigmodontinae
#9
Marcos Tobias de Santana Miglionico, Lúcio André Viana, Helene Santos Barbosa, Ester Maria Mota, Sócrates Fraga da Costa Neto, Edwards Frazão-Teixeira, Paulo Sergio D'Andrea
A total of 53 specimens of the montane grass mouse, Akodon montensis Thomas, 1913 were collected in the Serra dos Órgãos National Park (SONP) in November 2014 and July 2015. The fecal material was analyzed, and a prevalence of 7.5% was recorded for a new coccidian species of the genus Eimeria Schneider, 1875, with part of its endogenous development recorded in the small intestine. The oocysts of a new coccidian species of genus Eimeria are ellipsoidal to subspherical. The wall is bi-layered, c. 1.5 μm (1...
December 11, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29213153/reference-values-of-amino-acids-acylcarnitines-and-succinylacetone-by-tandem-mass-spectrometry-for-use-in-newborn-screening-in-southwest-colombia
#10
Nora Céspedes, Angela Valencia, Carlos Alberto Echeverry, Maria Isabel Arce-Plata, Cristóbal Colón, Daisy E Castiñeiras, Paula Margarita Hurtado, Jose Angel Cocho, Sócrates Herrera, Myriam Arévalo-Herrera
Introduction: Inborn errors of metabolism (IEM) represent an important public health problem due to current diagnosis and treatment limitations, poor life quality of affected patients, and consequent untimely child death. In contrast to classical methods, tandem mass spectrometry (MS/MS) has allowed simultaneous evaluation of multiple metabolites associated with IEM offering higher sensitivity, low false positive rates and high throughput. Aims: Determine concentration levels for amino acids and acylcarnitines in blood of newborns from Colombia, to establish reference values for further use in diagnosis of IEM...
September 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29211239/urban-malaria-transmission-in-a-non-endemic-area-in-the-andean-region-of-colombia
#11
Pablo E Chaparro, Karen Molina, Alberto Alzate, Julio Padilla, Myriam Arévalo-Herrera, Sócrates Herrera
BACKGROUND: Rapid urbanisation in difficult socio-economic conditions such as inadequate housing infrastructure, lack of public services, improper sanitation, and poor water drainage systems in vegetation-rich areas lead to ecological conditions that are conducive to the breeding of mosquitoes and transmission of malaria, in semi-urban and urban settings. OBJECTIVES: This study aimed to describe the cases of malaria that were reported in the peri-urban areas of Pereira (Colombia), between 2008 and 2015...
December 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29201508/how-localized-is-pathologically-localized-prostate-cancer-the-use-of-secondary-circulating-prostate-cells-as-a-marker-of-minimal-residual-disease-and-their-association-with-patient-outcome
#12
Nigel P Murray, Socrates Aedo, Cynthia Fuentealba, Eduardo Reyes, Omar Jacob
Objective: To determine the prognostic value of secondary circulating prostate cells (CPCs) in men with pT2 prostate cancer treated with radical prostatectomy. Material and methods: Prospective observational study was performed in men with pathologically confined prostate cancer who had been treated with radical prostatectomy. CPCs were obtained by differential gel centrifugation from 8 mL venous blood and identified by standard immunocytochemistry using anti-Prostate Specific Antigen (PSA) monoclonal antibody...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29199466/toxicological-evaluation-in-silico-and-in-vivo-of-secondary-metabolites-of-cissampelos-sympodialis-in-mus-musculus-mice-following-inhalation
#13
Mateus Feitosa Alves, Larissa Adilis Maria Paiva Ferreira, Francisco Allysson Assis Ferreira Gadelha, Laércia Karla Diega Paiva Ferreira, Mayara Barbalho Felix, Marcus Tullius Scotti, Luciana Scotti, Kardilândia Mendes de Oliveira, Sócrates Golzio Dos Santos, Margareth de Fátima Formiga Melo Diniz
The ethanolic extract of the leaves of Cissampelos sympodialis showed great pharmacological potential, with inflammatory and immunomodulatory activities, however, it showed some toxicological effects. Therefore, this study aims to verify the toxicological potential of alkaloids of the genus Cissampelos through in silico methodologies, to develop a method in LC-MS/MS verifying the presence of alkaloids in the infusion and to evaluate the toxicity of the infusion of the leaves of C. sympodialis when inhaled by Swiss mice...
December 4, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29192463/le-secret-professionnel-soignant%C3%A2-un-enjeu-de-d%C3%A3-mocratie-sanitaire-entre-immanence-et-ali%C3%A3-nation
#14
Silvère Pautier
For a long time considered as total and absolute, healthcare professional secrecy is today difficult to reconcile with care practices. Lots of paradoxes question its preservation in favour of general interest and public order against the protection of private interest within an individualistic normative society. Exploring this interrogation, the article's objective is to initiate an ethical discussion from a professional caregiver secrecy's historical and sociological evolution perspective. Thus, with the help of theoretical understandings, especially those by Michel Foucault, medical secrecy is considered a defense of rationality specific to populations' government...
November 21, 2017: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/29176083/marston-bates-visionary-environmentalist
#15
Socrates Litsios
Marston Bates (1906-1974) raised questions concerning man's relationship to nature, questions that are of much greater importance today than they were during his lifetime. He began his career with the Rockefeller Foundation as a mosquito expert, and by 1955 he had established himself as one of the key players in the field of human ecology through a series of publications that brought together in a clear and readable style the complexities involved in understanding human ecology. This article traces Bates's development and discusses how the Foundation failed to engage the subject of human ecology, even at a time when it recognized its critical importance to humankind...
2017: Perspectives in Biology and Medicine
https://www.readbyqxmd.com/read/29175951/socratic-questions-and-frozen-shoulders-teaching-without-telling
#16
John Launer
No abstract text is available yet for this article.
December 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29147033/socratic-seminar-with-data-a-strategy-to-support-student-discourse-and-understanding
#17
Joan Griswold, Loren Shaw, Maureen Munn
A Socratic seminar can be a powerful tool for increasing students' ability to analyze and interpret data. Most commonly used for text-based discussion, we found that using Socratic seminar to engage students with data contributes to student understanding by allowing them to reason through and process complex information as a group. This approach also provides teachers with insights about student misconceptions and understanding of concepts by listening to the student-driven discussion. This article reports on Socratic seminar in the context of a high school type 2 diabetes curriculum that explores gene and environment interactions...
August 2017: American Biology Teacher
https://www.readbyqxmd.com/read/29142431/characterization-of-leaf-extracts-of-schinus-terebinthifolius-raddi-by-gc-ms-and-chemometric-analysis
#18
Fabíola B Carneiro, Pablo Q Lopes, Ricardo C Ramalho, Marcus T Scotti, Sócrates G Santos, Luiz A L Soares
Background: Schinus terebinthifolius Raddi belongs to Anacardiacea family and is widely known as "aroeira." This species originates from South America, and its extracts are used in folk medicine due to its therapeutic properties, which include antimicrobial, anti-inflammatory, and antipyretic effects. The complexity and variability of the chemical constitution of the herbal raw material establishes the quality of the respective herbal medicine products. Objective: Thus, the purpose of this study was to investigate the variability of the volatile compounds from leaves of S...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29135964/the-killer-of-socrates-coniine-and-related-alkaloids-in-the-plant-kingdom
#19
REVIEW
Hannu Hotti, Heiko Rischer
Coniine, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system, eventually causing death by suffocation in mammals. Coniine's most famous victim is Socrates who was sentenced to death by poison chalice containing poison hemlock in 399 BC. In chemistry, coniine holds two historical records: It is the first alkaloid the chemical structure of which was established (in 1881), and that was chemically synthesized (in 1886)...
November 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29089519/characterization-of-an-anti-fetal-achr-monoclonal-antibody-isolated-from-a-myasthenia-gravis-patient
#20
Abhishek Saxena, Jo Stevens, Hakan Cetin, Inga Koneczny, Richard Webster, Konstantinos Lazaridis, Socrates Tzartos, Kathleen Vrolix, Gisela Nogales-Gadea, Barbie Machiels, Peter C Molenaar, Jan Damoiseaux, Marc H De Baets, Katja Simon-Keller, Alexander Marx, Angela Vincent, Mario Losen, Pilar Martinez-Martinez
We report here the sequence and functional characterization of a recombinantly expressed autoantibody (mAb 131) previously isolated from a myasthenia gravis patient by immortalization of thymic B cells using Epstein-Barr virus and TLR9 activation. The antibody is characterized by a high degree of somatic mutations as well as a 6 amino acid insertion within the VHCDR2. The recombinant mAb 131 is specific for the γ-subunit of the fetal AChR to which it bound with sub-nanomolar apparent affinity, and detected the presence of fetal AChR on a number of rhabdomyosarcoma cell lines...
October 31, 2017: Scientific Reports
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