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https://www.readbyqxmd.com/read/28930785/patients-and-clinicians-views-of-the-psychological-components-of-tinnitus-treatment-that-could-inform-audiologists-usual-care-a-delphi-survey
#1
Dean M Thompson, John Taylor, Deborah A Hall, Dawn-Marie Walker, Mary McMurran, Amanda Casey, David Stockdale, Debbie Featherstone, Derek J Hoare
OBJECTIVES: The aim of this study was to determine which components of psychological therapies are most important and appropriate to inform audiologists' usual care for people with tinnitus. DESIGN: A 39-member panel of patients, audiologists, hearing therapists, and psychologists completed a three-round Delphi survey to reach consensus on essential components of audiologist-delivered psychologically informed care for tinnitus. RESULTS: Consensus (≥80% agreement) was reached on including 76 of 160 components...
September 19, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28929973/vermont-a-multi-perspective-visual-interactive-platform-for-mutational-analysis
#2
Alexandre V Fassio, Pedro M Martins, Samuel da S Guimarães, Sócrates S A Junior, Vagner S Ribeiro, Raquel C de Melo-Minardi, Sabrina de A Silveira
BACKGROUND: A huge amount of data about genomes and sequence variation is available and continues to grow on a large scale, which makes experimentally characterizing these mutations infeasible regarding disease association and effects on protein structure and function. Therefore, reliable computational approaches are needed to support the understanding of mutations and their impacts. Here, we present VERMONT 2.0, a visual interactive platform that combines sequence and structural parameters with interactive visualizations to make the impact of protein point mutations more understandable...
September 13, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28912035/specific-removal-of-autoantibodies-by-extracorporeal-immunoadsorption-ameliorates-experimental-autoimmune-myasthenia-gravis
#3
Konstantinos Lazaridis, Ioannis Dalianoudis, Vasiliki Baltatzidi, Socrates J Tzartos
Myasthenia gravis (MG) is caused by autoantibodies, the majority of which target the muscle acetylcholine receptor (AChR). Plasmapheresis and IgG-immunoadsorption are useful therapy options, but are highly non-specific. Antigen-specific immunoadsorption would remove only the pathogenic autoantibodies, reducing the possibility of side effects while maximizing the benefit. We have extensively characterized such adsorbents, but in vivo studies are missing. We used rats with experimental autoimmune MG to perform antigen-specific immunoadsorptions over three weeks, regularly monitoring symptoms and autoantibody titers...
September 6, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28902908/histological-assessment-of-granulomas-in-natural-and-experimental-schistosoma-mansoni-infections-using-whole-slide-imaging
#4
Kátia B Amaral, Thiago P Silva, Felipe F Dias, Kássia K Malta, Florence M Rosa, Sócrates F Costa-Neto, Rosana Gentile, Rossana C N Melo
The pathology of schistosomiasis mansoni, a neglected tropical disease of great clinical and socioeconomic importance, results from the parasite eggs that become trapped in host tissues, particularly in the liver and intestines. Continuous antigenic stimulation from these eggs leads to recruitment of inflammatory cells to the sites of infection with formation of periovular granulomas. These complex structures have variable size and composition and are the most striking histopathological feature of schistosomiasis mansoni...
2017: PloS One
https://www.readbyqxmd.com/read/28902070/contending-with-preplanned-death-questions-for-clinicians
#5
Joel Yager
BACKGROUND AND OBJECTIVES: The goal of this column is to assist readers in reflecting on their attitudes and responses toward clinical and nonclinical situations involving preplanned deaths by decisionally capable individuals. Such circumstances range from encountering individuals in one's personal and professional lives who desire and intend to end their lives under their own terms, to having such individuals request assistance with predeath and postdeath arrangements. METHODS: Attending to pertinent literature, this essay uses Socratic inquiry to question conventional assumptions and attitudes, push readers' thoughts beyond typical comfort zones, and consider alternative modes of responding to challenges posed by preplanned death...
September 8, 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28898584/in-vitro-characterization-of-ritonavir-drug-products-and-correlation-to-human-in-vivo-performance
#6
Hao Xu, Socrates Vela, Yi Shi, Patrick Morroum, Ping Gao
Ritonavir (RTV) is a weakly basic drug with a pH-dependent solubility. In vitro dissolution and supersatuation behaviors of three Norvir® oral products including the Tablet, Powder and Solution were investigated by two biorelevant dissolution methods with pH alteration: a two-stage dissolution test and a biphasic dissolution-partition test. The two-stage dissolution test revealed a high degree of supersaturation of RTV from these products accompanied by the occurrence of RTV LLPS in biorelevant dissolution media...
September 12, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28866185/monitoring-structural-features-biocompatibility-and-biological-efficacy-of-gamma-irradiated-methotrexate-loaded-spray-dried-microparticles
#7
Alice R de Oliveira, Philippe C Mesquita, Paula R L Machado, Kleber J S Farias, Yêda M B de Almeida, Matheus F Fernandes-Pedrosa, Alianda M Cornélio, Eryvaldo Sócrates T do Egito, Arnóbio A da Silva-Júnior
In this study, biodegradable and biocompatible gamma irradiated poly-(dl-lactide-co-glycolide) (PLGA) spray-dried microparticles were prepared aiming to improve the efficacy of methotrexate (MTX). The experimental design included three formulations of microparticles containing distinct drug amount (9%, 18%, and 27% w/w) and three distinct gamma irradiation dose (15kGy, 25kGy, and 30kGy). The physicochemical and drug release properties of the microparticles supported their biocompatibility and biological efficacy studies in different cell lines...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28845202/reflection-as-a-deliberative-and-distributed-practice-assessing-neuro-enhancement-technologies-via-mutual-learning-exercises-mles
#8
Hub Zwart, Jonna Brenninkmeijer, Peter Eduard, Lotte Krabbenborg, Sheena Laursen, Gema Revuelta, Winnie Toonders
In 1968, Jürgen Habermas claimed that, in an advanced technological society, the emancipatory force of knowledge can only be regained by actively recovering the 'forgotten experience of reflection'. In this article, we argue that, in the contemporary situation, critical reflection requires a deliberative ambiance, a process of mutual learning, a consciously organised process of deliberative and distributed reflection. And this especially applies, we argue, to critical reflection concerning a specific subset of technologies which are actually oriented towards optimising human cognition (neuro-enhancement)...
2017: Nanoethics
https://www.readbyqxmd.com/read/28828994/computational-chemistry-study-of-natural-alkaloids-and-homemade-databank-to-predict-inhibitory-potential-against-key-enzymes-in-neurodegenerative-disease
#9
Vitor Prates Lorenzo, Mateus Feitosa Alves, Luciana Scotti, Sócrates Golzio Dos Santos, Margareth de Fátima Formiga Melo Diniz, Marcus Tullius Scotti
Cissampelos sympodialis Eichl is used in folk medicine for the treatment of various inflammatory diseases; several alkaloids were isolated from this species and some of them have anti-allergic activity, immunomodulatory and spasmolytic. Treatment of rats with the total tertiary alkaloid fraction showed an antidepressant effect. One of the depression causes can be the deficiency of monoamines, which is a factor displayed in patients with Alzheimer's disease. Theoretical studies using in silico methods have aided in the process of drug discovery...
August 21, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28815760/impact-microindentation-consistency-of-serial-measurements-and-alterations-in-patients-with-paget-s-disease-of-the-tibia
#10
Frank Malgo, Neveen A T Hamdy, Socrates E Papapoulos, Natasha M Appelman-Dijkstra
Impact microindentation is a new technique for the in vivo measurement of tissue-level properties of cortical bone in humans. To address issues related to the proper application of IMI in clinical practice and to directly examine cortical bone properties in patients with tibia pathology, we studied 11 subjects without tibia pathology and 9 patients with Paget's disease of the tibia in biochemical remission after bisphosphonate treatment. Serial indentations in the tibiae of both legs were performed in all subjects by a single operator until 10 adequate measurements were obtained in each tibia...
August 16, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28811270/developing-and-evaluating-jiapp-acceptability-and-usability-of-a-smartphone-app-system-to-improve-self-management-in-young-people-with-juvenile-idiopathic-arthritis
#11
Ran A Cai, Dominik Beste, Hema Chaplin, Socrates Varakliotis, Linda Suffield, Francesca Josephs, Debajit Sen, Lucy R Wedderburn, Yiannakis Ioannou, Stephen Hailes, Despina Eleftheriou
BACKGROUND: Flare-ups in juvenile idiopathic arthritis (JIA) are characterized by joint pain and swelling and often accompanied with fatigue, negative emotions, and reduced participation in activities. To minimize the impact of JIA on the physical and psychosocial development and well-being of young people (YP), it is essential to regularly monitor disease activity and side effects, as well as to support self-management such as adherence to treatment plans and engagement in general health-promoting behaviors...
August 15, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28798400/characterization-of-p-vivax-blood-stage-transcriptomes-from-field-isolates-reveals-similarities-among-infections-and-complex-gene-isoforms
#12
Adam Kim, Jean Popovici, Amélie Vantaux, Reingsey Samreth, Sophalai Bin, Saorin Kim, Camille Roesch, Li Liang, Huw Davies, Philip Felgner, Sócrates Herrera, Myriam Arévalo-Herrera, Didier Ménard, David Serre
Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient samples, which typically display a low proportion of parasites and asynchronous parasites. Here, we present stranded RNA-seq data generated directly from a small volume of blood from three Cambodian vivax malaria patients collected before treatment. Our analyses show surprising similarities of the parasite gene expression patterns across infections, despite extensive variations in parasite stage proportion...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28773009/understanding-drug-release-data-through-thermodynamic-analysis
#13
Marjorie Caroline Liberato Cavalcanti Freire, Francisco Alexandrino, Henrique Rodrigues Marcelino, Paulo Henrique de Souza Picciani, Kattya Gyselle de Holanda E Silva, Julieta Genre, Anselmo Gomes de Oliveira, Eryvaldo Sócrates Tabosa do Egito
Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively...
June 13, 2017: Materials
https://www.readbyqxmd.com/read/28747199/malaria-epidemiology-in-low-endemicity-areas-of-the-northern-coast-of-ecuador-high-prevalence-of-asymptomatic-infections
#14
Fabián E Sáenz, Andrea Arévalo-Cortés, Gabriela Valenzuela, Andrés F Vallejo, Angélica Castellanos, Andrea C Poveda-Loayza, Juan B Gutierrez, Alvaro Alvarez, Yi Heng Yan, Yoldy Benavides, Luis Enrique Castro, Myriam Arévalo-Herrera, Sócrates Herrera
BACKGROUND: The recent scale-up in malaria control measures in Latin America has resulted in a significant decrease in the number of reported cases in several countries including Ecuador, where it presented a low malaria incidence in recent years (558 reported cases in 2015) with occasional outbreaks of both Plasmodium falciparum and Plasmodium vivax in the coastal and Amazonian regions. This success in malaria control in recent years has led Ecuador to transition its malaria policy from control to elimination...
July 26, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28742044/multipolar-field-shaping-in-a-suprachoroidal-visual-prosthesis
#15
Calvin D Eiber, Socrates Dokos, Nigel H Lovell, Gregg J Suaning
Visual prostheses are now an available mobility aid for patients blinded by degenerative retinal diseases. However, the spatial resolution of existing devices is still insufficient to deliver normal levels of mobility vision without stimulation strategies which enable existing devices to deliver several different percepts per stimulation site. A stimulation strategy in which field shaping is achieved by incorporating multipolar (bipolar and tripolar) stimulation could convey additional information to a user of a visual prosthesis, as compared to monopolar stimulation, is investigated...
July 24, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28720658/ticagrelor-versus-aspirin-in-acute-embolic-stroke-of-undetermined-source
#16
Pierre Amarenco, Gregory W Albers, Hans Denison, J Donald Easton, Scott R Evans, Peter Held, Michael D Hill, Jenny Jonasson, Scott E Kasner, Per Ladenvall, Kazuo Minematsu, Carlos A Molina, Yongjun Wang, K S Lawrence Wong, S Claiborne Johnston
BACKGROUND AND PURPOSE: Ticagrelor is an effective antiplatelet therapy among patients with atherosclerotic disease and, therefore, could be more effective than aspirin in preventing recurrent stroke and cardiovascular events among patients with embolic stroke of unknown source (ESUS), which includes patients with ipsilateral stenosis <50% and aortic arch atherosclerosis. METHODS: We randomized 13 199 patients with a noncardioembolic, nonsevere ischemic stroke or high-risk transient ischemic attack to ticagrelor (180 mg loading dose on day 1 followed by 90 mg twice daily for days 2-90) or aspirin (300 mg on day 1 followed by 100 mg daily for days 2-90) within 24 hours of symptom onset...
July 18, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28715415/characterizing-the-malaria-rural-to-urban-transmission-interface-the-importance-of-reactive-case-detection
#17
Karen Molina Gómez, M Alejandra Caicedo, Alexandra Gaitán, Manuela Herrera-Varela, María Isabel Arce, Andrés F Vallejo, Julio Padilla, Pablo Chaparro, M Andreína Pacheco, Ananias A Escalante, Myriam Arevalo-Herrera, Sócrates Herrera
BACKGROUND: Reported urban malaria cases are increasing in Latin America, however, evidence of such trend remains insufficient. Here, we propose an integrated approach that allows characterizing malaria transmission at the rural-to-urban interface by combining epidemiological, entomological, and parasite genotyping methods. METHODS/PRINCIPAL FINDINGS: A descriptive study that combines active (ACD), passive (PCD), and reactive (RCD) case detection was performed in urban and peri-urban neighborhoods of Quibdó, Colombia...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28676055/malaria-in-brazil-colombia-peru-and-venezuela-current-challenges-in-malaria-control-and-elimination
#18
REVIEW
Judith Recht, André M Siqueira, Wuelton M Monteiro, Sonia M Herrera, Sócrates Herrera, Marcus V G Lacerda
In spite of significant progress towards malaria control and elimination achieved in South America in the 2000s, this mosquito-transmitted tropical disease remains an important public health concern in the region. Most malaria cases in South America come from Amazon rain forest areas in northern countries, where more than half of malaria is caused by Plasmodium vivax, while Plasmodium falciparum malaria incidence has decreased in recent years. This review discusses current malaria data, policies and challenges in four South American Amazon countries: Brazil, Colombia, Peru and the Bolivarian Republic of Venezuela...
July 4, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28666964/developing-quantitative-in-vitro-in-vivo-correlation-ivivc-for-fenofibrate-immediate-release-formulations-with-the-biphasic-dissolution-partition-test-method
#19
Hao Xu, Yi Shi, Socrates Vela, Patrick Marroum, Ping Gao
This study is to evaluate three fenofibrate formulations including Fournier® 200 mg capsule, Lipidil® 145 mg tablet, and a clinical HME 160 mg tablet by an in vitro biphasic method. Key experimental parameters were evaluated including the selection of biorelevant media, the USP IV flowrate and the USP paddle speed. Varying the hydrodynamic condition resulted in a significant impact on FEN concentration time profiles in both aqueous and octanol phases for these formulations. In vivo pharmacokinetic profiles of the HME tablet, the Lipidil tablet and Fournier capsule under the fasting and low fat fed states are reported...
June 27, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28655834/risk-for-major-bleeding-in-patients-receiving-ticagrelor-compared-with-aspirin-after-tia-or-acute-ischemic-stroke-in-the-socrates-study
#20
J Donald Easton, Maria Aunes, Gregory W Albers, Pierre Amarenco, Sara Bokelund Singh, Hans Denison, Scott R Evans, Peter Held, Marianne Jahreskog, Jenny Jonasson, Kazuo Mimematsu, Carlos A Molina, Yongjun Wang, K S Lawrence Wong, S Claiborne Johnston
Background -Patients with minor acute ischemic stroke (AIS) or transient ischemic attack (TIA) are at high risk for subsequent stroke, and more potent antiplatelet therapy in the acute setting is needed. However, the potential benefit of more intense antiplatelet therapy must be assessed in relation to the risk for major bleeding. The SOCRATES trial was the first trial with ticagrelor in patients with AIS or TIA, in which the efficacy and safety of ticagrelor were compared with aspirin. The main safety objective was assessment of PLATO-defined major bleeds on treatment, with special focus on intracranial hemorrhage (ICrH)...
June 27, 2017: Circulation
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