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Matthew T Drake, Jennifer S Fenske, Frank A Blocki, Claudia Zierold, Natasha Appelman-Dijkstra, Socrates Papapoulos, Sundeep Khosla
Sclerostin is a 190 amino acid protein secreted primarily by osteocytes. It was initially identified due to mutations in the SOST gene associated with high bone mass phenotypes. Much recent work has sought to determine the importance of sclerostin across an array of conditions which affect the human skeleton. However, accurate measurement of sclerostin from serum and plasma sources remains a significant impediment, with currently available commercial assays showing marked differences in measured sclerostin values...
March 14, 2018: Bone
Socrates Yong-da Wu, Man Ping Wang, William H Li, Antonio C Kwong, Vienna W Lai, Tai Hing Lam
OBJECTIVES: To investigate the effects of ever use of electronic cigarettes (ECs), many of which lack nicotine, on abstinence from convention cigarettes among Hong Kong adult smokers. METHODS: We collected data from 956 daily smokers in 2014-2015 regarding ever EC use and smoking behaviors at baseline, any and past 30-day EC use at the 3-month follow-up. Outcomes measured at 6 months included past 7-day point prevalence abstinence (PPA), biochemically validated quitting, smoking reduction (≥50% from baseline) and cessation attempt...
February 26, 2018: International Journal of Environmental Research and Public Health
Theodora Stratigou, Maria Dalamaga, Georgios Antonakos, Ioanna Marinou, Evaggelos Vogiatzakis, Gerasimos Socrates Christodoulatos, Irene Karampela, Athanasios G Papavassiliou
PURPOSE: Irisin, a newly discovered adipo-myokine, is implicated in the modulation of the adipose phenotype, increasing energy expenditure and ameliorating systemic metabolism. Our aim was to investigate circulating irisin in subclinical hypothyroidism (SH) and study its associations with cardiometabolic risk factors. METHODS: In a large case-control study, serum irisin, insulin resistance and lipid parameters, classic adipokines, inflammatory and hepatic biomarkers, and cardiovascular risk factors were determined in 120 consecutive patients with SH and 120 healthy controls matched on age, gender, and date of blood draw...
February 17, 2018: Endocrine
Sarah K Wise, Sandra Y Lin, Elina Toskala, Richard R Orlandi, Cezmi A Akdis, Jeremiah A Alt, Antoine Azar, Fuad M Baroody, Claus Bachert, G Walter Canonica, Thomas Chacko, Cemal Cingi, Giorgio Ciprandi, Jacquelynne Corey, Linda S Cox, Peter Socrates Creticos, Adnan Custovic, Cecelia Damask, Adam DeConde, John M DelGaudio, Charles S Ebert, Jean Anderson Eloy, Carrie E Flanagan, Wytske J Fokkens, Christine Franzese, Jan Gosepath, Ashleigh Halderman, Robert G Hamilton, Hans Jürgen Hoffman, Jens M Hohlfeld, Steven M Houser, Peter H Hwang, Cristoforo Incorvaia, Deborah Jarvis, Ayesha N Khalid, Maritta Kilpeläinen, Todd T Kingdom, Helene Krouse, Desiree Larenas-Linnemann, Adrienne M Laury, Stella E Lee, Joshua M Levy, Amber U Luong, Bradley F Marple, Edward D McCoul, K Christopher McMains, Erik Melén, James W Mims, Gianna Moscato, Joaquim Mullol, Harold S Nelson, Monica Patadia, Ruby Pawankar, Oliver Pfaar, Michael P Platt, William Reisacher, Carmen Rondón, Luke Rudmik, Matthew Ryan, Joaquin Sastre, Rodney J Schlosser, Russell A Settipane, Hemant P Sharma, Aziz Sheikh, Timothy L Smith, Pongsakorn Tantilipikorn, Jody R Tversky, Maria C Veling, De Yun Wang, Marit Westman, Magnus Wickman, Mark Zacharek
BACKGROUND: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR). METHODS: Using previously described methodology, specific topics were developed relating to AR...
February 2018: International Forum of Allergy & Rhinology
Syed A Haque, Socrates Jose P Cañete
Background: An HPLC method employing a post-column derivatization strategy using the cupric reducing antioxidant capacity reagent (CUPRAC reagent) for the determining antioxidants in plant-based materials leverages the separation capability of regular HPLC approaches while allowing for detection specificity for antioxidants. Methods: Three different column types, namely core-shell and porous silica including two chemically different core-shell materials (namely phenyl-hexyl and C18), were evaluated to assess potential improvements that could be attained by changing from a porous silica matrix to a core-shell matrix...
2018: Journal of Analytical Science and Technology
Socrates B Munoz, Vinayak Krishnamurti, Pablo Barrio, Thomas Mathew, G K Surya Prakash
A direct double functionalization involving both difluorination and hydroxylation of enamides is reported. With the appropriate combination of an electrophilic fluorinating reagent and H2O, the most convenient and ecofriendly hydroxylating agent, the preparation of 3-(difluoroalkyl)-3-hydroxyisoindolin-1-ones was achieved under basic or Brønsted acidic conditions. Suitable conditions for trifluorination as well as C(sp2)-H fluorination were also identified. Subsequent asymmetric functionalization of the obtained gem-difluorinated products has also been demonstrated...
January 31, 2018: Organic Letters
Nigel P Murray, Socrates Aedo, Cynthia Fuentealba, Eduardo Reyes, Anibal Salazar
Introduction: Minimal residual disease (MRD) remaining after curative therapy for prostate cancer has the potential for growth and can result in metastasis. Circulating prostate cells (CPCs) and bone marrow micro-metastasis (mM) could represent different types of MRD. We here determined; biochemical failure free survival rates; time to BF after 10 years follow-up; and the presence of CPCs and mM in patients treated with radical prostatectomy (RP) for prostate cancer. Methods and Patients: One month after RP, blood and bone marrow were sampled for assessment of CPCs and mM...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Maria Dalamaga, Gerasimos Socrates Christodoulatos, Christos S Mantzoros
Nicotinamide phosphoribosyl-transferase (Nampt) or pre-B cell colony-enhancing factor or visfatin represents a pleiotropic molecule acting as an enzyme, a cytokine and a growth factor. Intracellular Nampt plays an important role in cellular bioenergetics and metabolism, particularly NAD biosynthesis. NAD biosynthesis is critical in DNA repair, oncogenic signal transduction, transcription, genomic integrity and apoptosis. Although its insulin-mimetic function remains a controversial issue, extracellular Nampt presents proliferative, anti-apoptotic, pro-inflammatory, pro-angiogenic and metastatic properties...
January 9, 2018: Metabolism: Clinical and Experimental
Sergio Maimone, Francesca Saffioti, Roberto Filomia, Gaia Caccamo, Carlo Saitta, Socrate Pallio, Pierluigi Consolo, Sara Sabatini, Krizia Sitajolo, Maria Stella Franzè, Irene Cacciola, Giovanni Raimondo, Giovanni Squadrito
BACKGROUND: Patients with cirrhosis are at high risk of bacterial infections. Invasive procedures are generally believed to increase this susceptibility. AIMS: We investigated the incidence of bacterial infections in cirrhotic patients undergoing elective endoscopic variceal ligation (EVL). METHODS: We enrolled 60 consecutive cirrhotic patients who underwent a total number of 112 elective EVL procedures. One to seven bands were applied at each session until variceal eradication...
December 20, 2017: Digestive and Liver Disease
Shannon Gravely, Kellen Namusisi Nyamurungi, Steven Ndugwa Kabwama, Gabriel Okello, Lindsay Robertson, Kelvin Khow Chuan Heng, Achiri Elvis Ndikum, Adeniyi Samuel Oginni, Jean Christophe Rusatira, Socrates Kakoulides, Mark D Huffman, Salim Yusuf, Eduardo Bianco
OBJECTIVE: This study evaluated knowledge, opinions and compliance related to Uganda's comprehensive smoke-free law among hospitality venues in Kampala Uganda. DESIGN: This multi-method study presents cross-sectional findings of the extent of compliance in the early phase of Uganda's comprehensive smoke-free law (2 months postimplementation; pre-enforcement). SETTING: Bars, pubs and restaurants in Kampala Uganda. PROCEDURE AND PARTICIPANTS: A two-stage stratified cluster sampling procedure was used to select hospitality sites stratified by all five divisions in Kampala...
January 5, 2018: BMJ Open
Sócrates Bezerra de Matos, Roberto Meyer, Fernanda Washington de Mendonça Lima
BACKGROUND: Cytomegalovirus (CMV) is the main infectious agent causative of morbidity and mortality in transplant recipients. This study aimed to describe the occurrence and clinical features of CMV infection, and the optimum antigenemia assay cutoff associated with symptomatic infection. MATERIALS AND METHODS: This was a cohort study that investigated 87 patients undergoing renal transplantation. The patients were monitored with the CMV antigenemia assay performed weekly for the first 3 months post-transplantation and subsequently, when CMV infection was suspected clinically...
December 2017: Infection & Chemotherapy
Bee Ting Chan, Hak Koon Yeoh, Yih Miin Liew, Socrates Dokos, Amr Al Abed, Kok Han Chee, Yang F Abdul Aziz, Ganiga Srinivasaiah Sridhar, Karuthan Chinna, Einly Lim
OBJECTIVE: This study investigated the intraventricular flow dynamics in ischaemic heart disease patients. PATIENTS AND METHODS: Fourteen patients with normal ejection fraction and 16 patients with reduced ejection fraction were compared with 20 healthy individuals. Phase-contrast MRI was used to assess intraventricular flow variables and speckle-tracking echocardiography to assess myocardial strain and left ventricular (LV) dyssynchrony. Infarct size was acquired using delayed-enhancement MRI...
December 19, 2017: Coronary Artery Disease
Inge C M Van Seggelen-Damen, René Van Hezewijk, Anne S Helsdingen, Iwan G J H Wopereis
Reflection is a fuzzy concept. In this article we reveal the paradoxes involved in studying the nature of reflection. Whereas some scholars emphasize its discursive nature, we go further and underline its resemblance to the self-biased dialogue Socrates had with the slave in Plato's Meno. The individual and internal nature of the reflection process creates difficulty for studying it validly and reliably. We focus on methodological issues and use Hans Linschoten's view of coupled systems to identify, analyze, and interpret empirical research on reflection...
December 2017: Theory & Psychology
Gabriel Chaves Neto, João Euclides Fernandes Braga, Mateus Feitosa Alves, Liana Clébia de Morais Pordeus, Sócrates Golzio Dos Santos, Marcus Tullius Scotti, Reinaldo N Almeida, Margareth de Fátima Formiga Melo Diniz
The objective of this study was to investigate the anxiolytic effects of the essential oil (EO) of Citrus aurantium L. in patients experiencing crack withdrawal. This was developed with internal users in therapeutic communities in Paraíba, Brazil. The test population consisted of 51 volunteers, subdivided into three groups. To elicit anxiety, the Simulated Public Speaking (SPS) method was used. Physiological measures were assessed at specific phases during the experiment using appropriate equipment. Psychological measures of anxiety were assessed using the Trait-State Anxiety Inventory (IDATE) and the Analog Smoke Scale (HAS)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Anthony J Guarascio, Branden D Nemecek, David E Zimmerman
BACKGROUND AND PURPOSE: Student response systems (SRSs) or "clickers" are common tools that lecturers can implement into didactic lectures. Socrative is a convenient and free SRS application that can be downloaded on personal handheld devices and used by faculty and students. It is unknown if students prefer using this application and what advantages or disadvantages can be seen with Socrative's use. PURPOSE: To measure student preference of standard SRS methods compared to Socrative as well as the impact of Socrative use on student engagement during delivery of clinical pharmacy instruction EDUCATIONAL ACTIVITY AND SETTING: Standard SRS and Socrative incorporated lectures were presented to students during an infectious disease module...
September 2017: Currents in Pharmacy Teaching & Learning
Marcos Tobias de Santana Miglionico, Lúcio André Viana, Helene Santos Barbosa, Ester Maria Mota, Sócrates Fraga da Costa Neto, Edwards Frazão-Teixeira, Paulo Sergio D'Andrea
A total of 53 specimens of the montane grass mouse, Akodon montensis Thomas, 1913 were collected in the Serra dos Órgãos National Park (SONP) in November 2014 and July 2015. The fecal material was analyzed, and a prevalence of 7.5% was recorded for a new coccidian species of the genus Eimeria Schneider, 1875, with part of its endogenous development recorded in the small intestine. The oocysts of a new coccidian species of genus Eimeria are ellipsoidal to subspherical. The wall is bi-layered, c. 1.5 μm (1...
February 2018: Parasitology Research
Nora Céspedes, Angela Valencia, Carlos Alberto Echeverry, Maria Isabel Arce-Plata, Cristóbal Colón, Daisy E Castiñeiras, Paula Margarita Hurtado, Jose Angel Cocho, Sócrates Herrera, Myriam Arévalo-Herrera
Introduction: Inborn errors of metabolism (IEM) represent an important public health problem due to current diagnosis and treatment limitations, poor life quality of affected patients, and consequent untimely child death. In contrast to classical methods, tandem mass spectrometry (MS/MS) has allowed simultaneous evaluation of multiple metabolites associated with IEM offering higher sensitivity, low false positive rates and high throughput. Aims: Determine concentration levels for amino acids and acylcarnitines in blood of newborns from Colombia, to establish reference values for further use in diagnosis of IEM...
September 30, 2017: Colombia Médica: CM
Pablo E Chaparro, Karen Molina, Alberto Alzate, Julio Padilla, Myriam Arévalo-Herrera, Sócrates Herrera
BACKGROUND: Rapid urbanisation in difficult socio-economic conditions such as inadequate housing infrastructure, lack of public services, improper sanitation, and poor water drainage systems in vegetation-rich areas lead to ecological conditions that are conducive to the breeding of mosquitoes and transmission of malaria, in semi-urban and urban settings. OBJECTIVES: This study aimed to describe the cases of malaria that were reported in the peri-urban areas of Pereira (Colombia), between 2008 and 2015...
December 2017: Memórias do Instituto Oswaldo Cruz
Nigel P Murray, Socrates Aedo, Cynthia Fuentealba, Eduardo Reyes, Omar Jacob
Objective: To determine the prognostic value of secondary circulating prostate cells (CPCs) in men with pT2 prostate cancer treated with radical prostatectomy. Material and methods: Prospective observational study was performed in men with pathologically confined prostate cancer who had been treated with radical prostatectomy. CPCs were obtained by differential gel centrifugation from 8 mL venous blood and identified by standard immunocytochemistry using anti-Prostate Specific Antigen (PSA) monoclonal antibody...
December 2017: Turkish Journal of Urology
Mateus Feitosa Alves, Larissa Adilis Maria Paiva Ferreira, Francisco Allysson Assis Ferreira Gadelha, Laércia Karla Diega Paiva Ferreira, Mayara Barbalho Felix, Marcus Tullius Scotti, Luciana Scotti, Kardilândia Mendes de Oliveira, Sócrates Golzio Dos Santos, Margareth de Fátima Formiga Melo Diniz
The ethanolic extract of the leaves of Cissampelos sympodialis showed great pharmacological potential, with inflammatory and immunomodulatory activities, however, it showed some toxicological effects. Therefore, this study aims to verify the toxicological potential of alkaloids of the genus Cissampelos through in silico methodologies, to develop a method in LC-MS/MS verifying the presence of alkaloids in the infusion and to evaluate the toxicity of the infusion of the leaves of C. sympodialis when inhaled by Swiss mice...
December 4, 2017: Natural Product Research
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