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https://www.readbyqxmd.com/read/28546097/10-years-of-denosumab-treatment-in-postmenopausal-women-with-osteoporosis-results-from-the-phase-3-randomised-freedom-trial-and-open-label-extension
#1
Henry G Bone, Rachel B Wagman, Maria L Brandi, Jacques P Brown, Roland Chapurlat, Steven R Cummings, Edward Czerwiński, Astrid Fahrleitner-Pammer, David L Kendler, Kurt Lippuner, Jean-Yves Reginster, Christian Roux, Jorge Malouf, Michelle N Bradley, Nadia S Daizadeh, Andrea Wang, Paula Dakin, Nicola Pannacciulli, David W Dempster, Socrates Papapoulos
BACKGROUND: Long-term safety and efficacy of osteoporosis treatment are important because of the chronic nature of the disease. We aimed to assess the long-term safety and efficacy of denosumab, which is widely used for the treatment of postmenopausal women with osteoporosis. METHODS: In the multicentre, randomised, double-blind, placebo-controlled, phase 3 FREEDOM trial, postmenopausal women aged 60-90 years with osteoporosis were enrolled in 214 centres in North America, Europe, Latin America, and Australasia and were randomly assigned (1:1) to receive 60 mg subcutaneous denosumab or placebo every 6 months for 3 years...
May 22, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28544813/nursing-diagnosis-risk-for-delayed-surgical-recovery-00246-concept-clarification-and-definition-of-empirical-referents
#2
Simone Martins Rembold, Rosimere Ferreira Santana, Priscilla Alfradique de Souza, Sócrates Miranda de Oliveira Xavier Schwartz
PURPOSE: To clarify the concept of risk for delayed surgical recovery (00246) and to define the empirical referents for identification of predictive factors of delay in recovery. METHOD: A concept analysis was developed based on the eight steps proposed by Walker and Avant. RESULTS: Defining attributes were determined and antecedents and consequents identified. Cases were proposed cases and empirical referents established. CONCLUSION: The results provided evidences and instrumentalize empirical referents, which may support an accurate nursing diagnosis...
May 23, 2017: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/28541240/homosexuality-according-to-ancient-greek-physicians
#3
K Laios, M M Moschos, E Koukaki, M-I Kontaxaki, G Androutsos
Homosexuality and pedophilia in ancient Greece greatly concerned many researchers who were mainly interested in highlighting the social aspect of this phenomenon in ancient Greek society. An important source on the subject was the paintings of a man and his lover in attic black and red figured pottery, up to the end of the 5th century BC. Another main source was the information that derived from the texts of ancient Greek literature, especially poetry. Homosexuality was not only referring to relationships between males, but it was also manifested in lesbian love...
January 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28540473/innovative-use-of-single-incision-internal-fixation-of-distal-clavicle-fractures-augmented-with-coracoclavicular-stabilisation
#4
Rajpal Nandra, Tomasz Kowalski, Socrates Kalogrianitis
INTRODUCTION: The management of displaced fractures of the distal clavicle remains controversial, particularly in younger patients where there is no consensus as to which surgical intervention is best. Each surgical method has unique surgical complications and rates of persistent pain and post-traumatic arthritis. We report an innovative surgical technique using a plate fixation augmented with minimally invasive tension slide coracoclavicular fixation using a cortical tenodesis button (8...
May 24, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28531204/messinian-age-and-savannah-environment-of-the-possible-hominin-graecopithecus-from-europe
#5
Madelaine Böhme, Nikolai Spassov, Martin Ebner, Denis Geraads, Latinka Hristova, Uwe Kirscher, Sabine Kötter, Ulf Linnemann, Jérôme Prieto, Socrates Roussiakis, George Theodorou, Gregor Uhlig, Michael Winklhofer
Dating fossil hominids and reconstructing their environments is critically important for understanding human evolution. Here we date the potentially oldest hominin, Graecopithecus freybergi from Europe and constrain the environmental conditions under which it thrived. For the Graecopithecus-bearing Pikermi Formation of Attica/Greece, a saline aeolian dust deposit of North African (Sahara) provenance, we obtain an age of 7.37-7.11 Ma, which is coeval with a dramatic cooling in the Mediterranean region at the Tortonian-Messinian transition...
2017: PloS One
https://www.readbyqxmd.com/read/28516329/screening-for-lipoprotein-receptor-related-protein-4-agrin-and-titin-antibodies-and-exploring-the-autoimmune-spectrum-in-myasthenia-gravis
#6
Isabell Cordts, Nicolas Bodart, Kathi Hartmann, Katerina Karagiorgou, John S Tzartos, Lin Mei, Jens Reimann, Philip Van Damme, Michael H Rivner, Alain Vigneron, Joachim Weis, Jörg B Schulz, Socrates J Tzartos, Kristl G Claeys
In autoimmune myasthenia gravis (MG), the identification of antibodies and characterization of serological subgroups is of great importance for diagnosis and management of the disease. Our aims were to study the frequency of antibodies against lipoprotein-related protein 4 (LRP4), agrin, and titin using the most recent techniques, and to characterize corresponding clinical features and autoimmune diseases (AID) in 100 MG-patients. The antibody frequencies in the 55 AChR-antibody positive patients were 7% LRP4, 5% agrin, 53% titin, and in the 45 AChR-antibody negative patients 2% MuSK, 2% LRP4, 2% agrin, and 27% titin...
May 17, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28509873/leishmanicidal-activity-and-structure-activity-relationships-of-essential-oil-constituents
#7
Audrey R S T Silva, Ricardo Scher, Flaviane V Santos, Sebastião R Ferreira, Sócrates C H Cavalcanti, Cristiane B Correa, Lilian L Bueno, Ricardo J Alves, Damião P Souza, Ricardo T Fujiwara, Silvio S Dolabella
Several constituents of essential oils have been shown to be active against pathogens such as bacteria, fungi, and protozoa. This study demonstrated the in vitro action of ten compounds present in essential oils against Leishmania amazonensis promastigotes. With the exception of p-cymene, all evaluated compounds presented leishmanicidal activity, exhibiting IC50 between 25.4 and 568.1 μg mL(-1). Compounds with the best leishmanicidal activity presented a phenolic moiety (IC50 between 25.4 and 82.9 μg mL(-1))...
May 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28500919/kinetics-of-circulating-fetuin-a-may-predict-mortality-independently-from-adiponectin-high-molecular-weight-adiponectin-and-prognostic-factors-in-critically-ill-patients-with-sepsis-a-prospective-study
#8
Irene Karampela, Evangelia Kandri, Georgios Antonakos, Evangelos Vogiatzakis, Gerasimos Socrates Christodoulatos, Athina Nikolaidou, George Dimopoulos, Apostolos Armaganidis, Maria Dalamaga
PURPOSE: Fetuin-A and adiponectin, major hepatokine and adipokine respectively, have been implicated in systematic inflammation. Our aim was to jointly investigate whether kinetics of circulating fetuin-A, adiponectin and its isoform HMWA predict 28-day mortality in sepsis. MATERIALS AND METHODS: In a prospective study, serum fetuin-A, adiponectin and HMWA were determined in 102 ICU patients fulfilling the diagnostic criteria of SEPSIS-3, at enrollment and one week after, and in 102 healthy controls matched on age and gender...
May 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28484896/psoriasis-is-associated-with-risk-of-obstructive-sleep-apnea-independently-from-metabolic-parameters-and-other-comorbidities-a-large-hospital-based-case-control-study
#9
Evangelia Papadavid, Maria Dalamaga, Katerina Vlami, Dimitra Koumaki, Sotirios Gyftopoulos, Gerasimos Socrates Christodoulatos, Spyridon Papiris, Dimitrios Rigopoulos
PURPOSE: Obstructive sleep apnea (OSA) represents a breathing disorder during sleep with significant health consequences. Few studies have examined the prevalence of OSA in psoriatic patients and whether OSA may be associated with psoriasis risk. We aimed to explore: (1) the inverse relationship, that is whether psoriasis might represent an independent predictor of OSA and its severity considering important predisposing factors and (2) the psoriatic phenotype related to severe OSA. METHODS: In a large hospital-based case-control study, we examined a total of 253 patients with OSA and a control group of 104 subjects without OSA, who underwent full nocturnal polysomnography and dermatologic examination...
May 8, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28480154/congenital-tracheobronchomegaly-mounier-kuhn-syndrome-in-a-woman-with-human-immunodeficiency-virus-a-case-report
#10
Amanda Fletcher, Justin Stowell, Socrates Jamoulis
Congenital tracheobronchomegaly (Mounier-Kuhn Syndrome, MKS) is a rare idiopathic disorder characterized by dilation of the central airways, including the trachea and first through fourth order bronchi. MKS disproportionately affects men and results in chronic respiratory tract infections. The diagnosis is made through the synthesis of clinical and radiological data. Here we report a unique case of MKS in a patient with human immunodeficiency virus (HIV) infection. A 45-year-old African American woman with a past medical history of HIV, tobacco and recreational drug abuse, chronic obstructive pulmonary disease, sleep apnea, and a 15-year history of recurrent respiratory infections presented with dyspnea, wheezing, a productive cough, increased yellow-green sputum production, and subjective fevers...
April 4, 2017: Curēus
https://www.readbyqxmd.com/read/28471266/preparation-and-characterization-of-safe-microparticles-based-on-xylan
#11
Silvana Cartaxo da Costa Urtiga, Camilla Aquino Azevedo de Lucena Gabi, Giovanna Rodrigues de Araújo Eleamen, Bartolomeu Santos Souza, Hilzeth de Luna Freire Pessôa, Henrique Rodrigues Marcelino, Elisângela Afonso de Moura Mendonça, Eryvaldo Sócrates Tabosa do Egito, Elquio Eleamen Oliveira
This work describes the preparation and evaluation of safe xylan-based microparticles prepared by cross-linking polymerization using sodium trimetaphosphate. The resulting microparticles were evaluated for morphology, particle size, polymer-cross-link agent interaction and in vitro toxicity. The microparticles showed narrow monodisperse size distributions with their mean sizes being between 3.5 µm and 12.5 µm in dried state. FT-IR analyses confirmed the interaction between sodium trimetaphosphate and xylan during the cross-linking process with formation of phosphate ester bonds...
May 4, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28452148/understanding-structure-function-relationships-of-the-human-neuronal-acetylcholine-receptor-insights-from-the-first-crystal-structures-of-neuronal-subunits
#12
REVIEW
Petros Giastas, Marios Zouridakis, Socrates J Tzartos
Nicotinic acetylcholine receptors (nAChRs) are the best studied members of the superfamily of pentameric ligand-gated ion channels (pLGICs). Neuronal nAChRs regulate neuronal excitability and neurotransmitter release in the nervous system and form either homo- or hetero-pentameric complexes with various combinations among eleven neuronal nAChR subunits (α2-7, α9, α10 and β2-4) known to exist in humans. In addition to their wide distribution in the nervous system, neuronal nAChRs have been also found in immune cells and many peripheral tissues...
April 27, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28451025/-asteroid-hyalopathy-benson-s-disease-about-a-case
#13
Yogolelo Asani Bienvenu, Musau Nkola Angel, Kabamba Ngombe Leon, Kapalu Mwangala Socrate, Iye Ombamba Kayimba Bruno, Chenge Borasisi Gaby
We here report a case of a 58 year-old diabetic male patient with asteroid hyalopathy, an affection rarely described in the literature. This study can help focus the attention of scientists on the pathologies of the vitreous disorders in diabetic patients as well as on other systemic diseases asteroid hyalopathy may be associated with.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28449657/influence-of-subject-discontinuation-on-long-term-nonvertebral-fracture-rate-in-the-denosumab-freedom-extension-study
#14
Jonathan D Adachi, Henry G Bone, Nadia S Daizadeh, Paula Dakin, Socrates Papapoulos, Peyman Hadji, Chris Recknor, Michael A Bolognese, Andrea Wang, Celia J F Lin, Rachel B Wagman, Serge Ferrari
BACKGROUND: Denosumab treatment for up to 8 years in the FREEDOM study and Extension was associated with low fracture incidence. It was not clear whether subjects who discontinued during the study conduct had a higher risk of fracture than those who remained enrolled, thereby underestimating the true fracture risk for the entire trial cohort. Thus, we explored the influence of early withdrawals on nonvertebral fracture incidence during the Extension study. METHODS: To understand the potential effect of depletion of susceptible subjects on fracture incidence, we first evaluated subject characteristics in patients who were enrolled in the Extension vs those who were not...
April 27, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28436028/chronic-bullous-disease-of-childhood-with-igg-reactivity-to-p200-antigen
#15
Aikaterini Patsatsi, Parthena Meltzanidou, Socrates Katafigiotis, Dimitrios Sotiriadis, Enno Schmidt, Alexandros Lambropoulos
No abstract text is available yet for this article.
April 24, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28426377/development-of-the-sports-organization-concussion-risk-assessment-tool-socrat
#16
A Yeung, V Munjal, N Virji-Babul
OBJECTIVE: In this paper, we describe the development of a novel tool-the Sports Organization Concussion Risk Assessment Tool (SOCRAT)-to assist sport organizations in assessing the overall risk of concussion at a team level by identifying key risk factors. METHODS: We first conducted a literature review to identify risk factors of concussion using ice hockey as a model. We then developed an algorithm by combining the severity and the probability of occurrence of concussions of the identified risk factors by adapting a risk assessment tool commonly used in engineering applications...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28398359/-the-socrates-reduced-study
#17
Domenico Scrutinio, Andrea Di Lenarda, Antonella Cherubini
No abstract text is available yet for this article.
February 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28369340/vericiguat-in-patients-with-worsening-chronic-heart-failure-and-preserved-ejection-fraction-results-of-the-soluble-guanylate-cyclase-stimulator-in-heart-failure-patients-with-preserved-ef-socrates-preserved-study
#18
Burkert Pieske, Aldo P Maggioni, Carolyn S P Lam, Elisabeth Pieske-Kraigher, Gerasimos Filippatos, Javed Butler, Piotr Ponikowski, Sanjiv J Shah, Scott D Solomon, Andrea-Viviana Scalise, Katharina Mueller, Lothar Roessig, Mihai Gheorghiade
Aims: To determine tolerability and the optimal dose regimen of the soluble guanylate cyclase stimulator vericiguat in patients with chronic heart failure and preserved ejection fraction (HFpEF). Methods and results: SOCRATES-PRESERVED was a prospective, randomized, placebo-controlled double-blind, Phase 2b dose-finding study in patients with HFpEF (ejection fraction ≥ 45%). Patients received vericiguat once daily at 1.25 or 2.5 mg fixed doses, or 5 or 10 mg titrated from a 2...
April 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28369085/defining-the-next-generation-of-plasmodium-vivax-diagnostic-tests-for-control-and-elimination-target-product-profiles
#19
Xavier C Ding, Maria Paz Ade, J Kevin Baird, Qin Cheng, Jane Cunningham, Mehul Dhorda, Chris Drakeley, Ingrid Felger, Dionicia Gamboa, Matthias Harbers, Socrates Herrera, Naomi Lucchi, Alfredo Mayor, Ivo Mueller, Jetsumon Sattabongkot, Arsène Ratsimbason, Jack Richards, Marcel Tanner, Iveth J González
The global prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical attacks without involving another mosquito bite. The diagnosis of acute patent P. vivax malaria relies primarily on light microscopy...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28364296/juvenile-onset-myasthenia-gravis-autoantibody-status-clinical-characteristics-and-genetic-polymorphisms
#20
Yu Hong, Geir Olve Skeie, Paraskevi Zisimopoulou, Katerina Karagiorgou, Socrates J Tzartos, Xiang Gao, Yao-Xian Yue, Fredrik Romi, Xu Zhang, Hai-Feng Li, Nils Erik Gilhus
Myasthenia gravis (MG) is an autoimmune disorder mediated by antibodies against proteins at the neuromuscular junction. Juvenile-onset MG (JMG) has been reported to have special characteristics. It is still unclear whether there are any pathogenic and genetic differences between juvenile and adult MG. In this study, we evaluated the clinical characteristics, autoantibody status (antibodies against AChR, MuSK, LRP4, titin and RyR) and genetic susceptibility (CHRNA1, CTLA4 and AIRE) in 114 Chinese JMG patients, and compared with 207 young adult MG patients (onset age 18-40 years)...
May 2017: Journal of Neurology
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