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https://www.readbyqxmd.com/read/27899747/ticagrelor-in-acute-stroke-or-transient-ischemic-attack-in-asian-patients-from-the-socrates-trial-acute-stroke-or-transient-ischemic-attack-treated-with-aspirin-or-ticagrelor-and-patient-outcomes
#1
Yongjun Wang, Kazuo Minematsu, Ka Sing Lawrence Wong, Pierre Amarenco, Gregory W Albers, Hans Denison, J Donald Easton, Scott R Evans, Peter Held, Jenny Jonasson, Carlos A Molina, S Claiborne Johnston
BACKGROUND AND PURPOSE: In the SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), ticagrelor was not superior to aspirin. Because of differences in patient demographics and stroke disease pattern in Asia, outcomes of ticagrelor versus aspirin were assessed among Asian patients in a prespecified exploratory analysis. METHODS: Baseline demographics, treatment effects, and safety of ticagrelor and aspirin were assessed among Asian patients...
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27880808/natural-schistosoma-mansoni-infection-in-the-wild-reservoir-nectomys-squamipes-leads-to-excessive-lipid-droplet-accumulation-in-hepatocytes-in-the-absence-of-liver-functional-impairment
#2
Kátia B Amaral, Thiago P Silva, Kássia K Malta, Lívia A S Carmo, Felipe F Dias, Mariana R Almeida, Gustavo F S Andrade, Jefferson S Martins, Roberto R Pinho, Sócrates F Costa-Neto, Rosana Gentile, Rossana C N Melo
Schistosomiasis is a neglected tropical disease of a significant public health impact. The water rat Nectomys squamipes is one of the most important non-human hosts in the schistosomiasis mansoni transmission in Brazil, being considered a wild reservoir. Cellular mechanisms that contribute to the physiological adaptation of this rodent to the Schistosoma mansoni parasite are poorly understood. Here we identified, for the first time, that a hepatic steatosis, a condition characterized by excessive lipid accumulation with formation of lipid droplets (LDs) within hepatocytes, occurs in response to the natural S...
2016: PloS One
https://www.readbyqxmd.com/read/27855286/casiopeina-iii-ea-a-copper-containing-small-molecule-inhibits-the-in-vitro-growth-of-primitive-hematopoietic-cells-from-chronic-myeloid-leukemia
#3
Antonieta Chavez-Gonzalez, Sandra Centeno-Llanos, Dafne Moreno-Lorenzana, Miguel Angel Sandoval-Esquivel, Socrates Aviles-Vazquez, María Elena Bravo-Gomez, Lena Ruiz-Azuara, Manuel Ayala-Sanchez, Hector Torres-Martinez, Hector Mayani
Several novel compounds have been developed for the treatment of different types of leukemia. In the present study, we have assessed the in vitro effects of Casiopeina III-Ea, a copper-containing small molecule, on cells from patients with Chronic Myeloid Leukemia (CML). We included primary CD34(+) Lineage-negative (Lin(-)) cells selected from CML bone marrow, as well as the K562 and MEG01 cell lines. Bone marrow cells obtained from normal individuals - both total mononuclear cells as well as CD34(+) Lin(-) cells- were used as controls...
November 3, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27847818/aqueous-leaf-extract-of-jatropha-mollissima-pohl-bail-decreases-local-effects-induced-by-bothropic-venom
#4
Jacyra Antunes Dos Santos Gomes, Juliana Félix-Silva, Júlia Morais Fernandes, Juliano Geraldo Amaral, Norberto Peporine Lopes, Eryvaldo Sócrates Tabosa do Egito, Arnóbio Antônio da Silva-Júnior, Silvana Maria Zucolotto, Matheus de Freitas Fernandes-Pedrosa
Snakebites are a serious worldwide public health problem. In Brazil, about 90% of accidents are attributed to snakes from the Bothrops genus. The specific treatment consists of antivenom serum therapy, which has some limitations such as inability to neutralize local effects, difficult access in some regions, risk of immunological reactions, and high cost. Thus, the search for alternative therapies to treat snakebites is relevant. Jatropha mollissima (Euphorbiaceae) is a medicinal plant popularly used in folk medicine as an antiophidic remedy...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27835951/obesity-and-diabetes-mellitus-association-in-rural-community-of-katana-south-kivu-in-eastern-democratic-republic-of-congo-bukavu-observ-cohort-study-results
#5
Philippe Bianga Katchunga, Justin Cikomola, Christian Tshongo, Arsene Baleke, David Kaishusha, Patrick Mirindi, Théodore Tamburhe, Yves Kluyskens, Antoine Sadiki, Socrate Bwanamudogo, Zacharie Kashongwe, Marc Twagirumukiza
BACKGROUND: Factual data exploring the relationship between obesity and diabetes mellitus prevalence from rural areas of sub-Saharan Africa remain scattered and are unreliable. To address this scarceness, this work reports population study data describing the relationship between the obesity and the diabetes mellitus in the general population of the rural area of Katana (South Kivu in the Democratic Republic of the Congo). METHODS: A cohort of three thousand, nine hundred, and sixty-two (3962) adults (>15 years old) were followed between 2012 and 2015 (or 4105 person-years during the observation period), and data were collected using the locally adjusted World Health Organization's (WHO) STEPwise approach to Surveillance (STEPS) methodology...
November 11, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27811938/bone-romosozumab-getting-there-but-not-quite-yet
#6
Socrates E Papapoulos
No abstract text is available yet for this article.
November 4, 2016: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/27803771/efficacy-and-safety-of-endoscopic-papillary-balloon-dilation-for-the-removal-of-bile-duct-stones-data-from-a-real-life-multicenter-study-on-dilation-assisted-stone-extraction
#7
Roberto Di Mitri, Filippo Mocciaro, Socrate Pallio, Giulia Maria Pecoraro, Andrea Tortora, Claudio Zulli, Simona Attardo, Attilio Maurano
AIM: To report data on Dilation-Assisted Stone Extraction (DASE) use in clinical practice and its efficacy and safety trough three Italian referral centers for biliopancreatic diseases treatment. METHODS: From January 2011 to December 2015 we collected data on 120 patients treated with DASE. Technical success was obtained when the endoscopist was able to place the balloon trough the papilla inflating the balloon until the final diameter for an adequate time (at least 30 s)...
October 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27760143/protective-efficacy-of-plasmodium-vivax-radiation-attenuated-sporozoites-in-colombian-volunteers-a-randomized-controlled-trial
#8
Myriam Arévalo-Herrera, Juan M Vásquez-Jiménez, Mary Lopez-Perez, Andrés F Vallejo, Andrés B Amado-Garavito, Nora Céspedes, Angélica Castellanos, Karen Molina, Johanna Trejos, José Oñate, Judith E Epstein, Thomas L Richie, Sócrates Herrera
BACKGROUND: Immunizing human volunteers by mosquito bite with radiation-attenuated Plasmodium falciparum sporozoites (RAS) results in high-level protection against infection. Only two volunteers have been similarly immunized with P. vivax (Pv) RAS, and both were protected. A phase 2 controlled clinical trial was conducted to assess the safety and protective efficacy of PvRAS immunization. METHODOLOGY/PRINCIPAL FINDINGS: A randomized, single-blinded trial was conducted...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27750051/medical-pimping-versus-the-socratic-method-of-teaching
#9
Eric R Carlson
No abstract text is available yet for this article.
September 21, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27742500/sclerostin-deficiency-in-humans
#10
Antoon H van Lierop, Natasha M Appelman-Dijkstra, Socrates E Papapoulos
Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasia caused by genetic defects in the synthesis of sclerostin. In this article we review the demographic, clinical, biochemical, radiological, and histological characteristics of patients with sclerosteosis and van Buchem disease that led to a better understanding of the role of sclerostin in bone metabolism in humans and we discuss the relevance of these findings for the development of new therapeutics for the treatment of patients with osteoporosis...
October 11, 2016: Bone
https://www.readbyqxmd.com/read/27708974/evaluating-disease-activity-in-patients-with-ankylosing-spondylitis-and-rheumatoid-arthritis-using-99mtc-glucosamine
#11
Nicholas Manolios, Marina Ali, Bradley Camden, Elham Aflaky, Katrina Pavic, Andrew Markewycz, Robert De Costa, Socrates Angelides
OBJECTIVE: To evaluate the clinical utility of a novel radiotracer, (99m)Tc-glucosamine, in assessing disease activity of both rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Material and Methods: Twenty-five patients with RA (nine males and 16 females) and 12 patients with AS (all male) at various stages of disease were recruited for the study. A clinical history and examination was performed, followed by the measurement of hematological, biochemical, and autoimmune serological parameters to assess disease activity...
June 2016: Eur J Rheumatol
https://www.readbyqxmd.com/read/27694549/impacts-of-socratic-questioning-on-moral-reasoning-of-nursing-students
#12
Camellia Torabizadeh, Leyla Homayuni, Marzieh Moattari
BACKGROUND: Nurses are often faced with complex situations that made them to make ethical decisions; and to make such decisions, they need to possess the power of moral reasoning. Studies in Iran show that the majority of nursing students lack proper ethical development. Socratic teaching is a student-centered method which is strongly opposed to the lecturing method. OBJECTIVES: This study was conducted to evaluate the impacts of Socratic questioning on the moral reasoning of the nursing students...
September 30, 2016: Nursing Ethics
https://www.readbyqxmd.com/read/27692317/lungworm-heterostrongylus-heterostrongylus-travassos-1925-from-the-black-eared-opossum-in-south-america-morphologic-histopathological-and-phylogenetic-aspects
#13
Sócrates Fraga da Costa Neto, Raquel de Oliveira Simões, Éster Maria Mota, Roberto do Val Vilela, Eduardo José Lopes Torres, Helene Santos Barbosa, Rosana Gentile, Arnaldo Maldonado Junior
Nematode parasites of the cardiopulmonary system of livestock and pet animals have been receiving attention due to the pathogenic effects they produce in the course of the infection. However, parasitism in wild animals by metastrongilid nematodes has been neglected, resulting in potential risk to wildlife. Heterostrongylus heterostrongylus is the etiological agent of bronchial pneumonia in the black-eared opossum, Didelphis aurita, a widely distributed marsupial frequently reported to inhabit areas from wild environments to peri-urban spaces...
September 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27689934/epigenetic-signatures-at-the-runx2-p1-and-sp7-gene-promoters-control-osteogenic-lineage-commitment-of-umbilical-cord-derived-mesenchymal-stem-cells
#14
Hugo Sepulveda, Rodrigo Aguilar, Catalina P Prieto, Francisco Bustos, Sócrates Aedo, José Lattus, Brigitte van Zundert, Veronica Palma, Martin Montecino
Wharton's Jelly mesenchymal stem cells (WJ-MSCs) are an attractive potential source of multipotent stem cells for bone tissue replacement therapies. However, the molecular mechanisms involved in their osteogenic conversion are poorly understood. Particularly, epigenetic control operating at the promoter regions of the two master regulators of the osteogenic program, RUNX2/P57 and SP7 has not yet been described in WJ-MSCs. Via quantitative PCR profiling and chromatin immunoprecipitation (ChIP) studies here we analyze the ability of WJ-MSCs to engage osteoblast lineage...
September 30, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27663047/corrigendum-re-role-of-magnetic-resonance-imaging-in-prostate-cancer-screening-a-pilot-study-within-the-g%C3%A3-teborg-randomised-screening-trial-eur-urol-2016-70-566-73
#15
Anna Grenabo Bergdahl, Ulrica Wilderäng, Gunnar Aus, Sigrid Carlsson, Jan-Erik Damber, Maria Frånlund, Kjell Geterud, Ali Khatami, Andreas Socratous, Johan Stranne, Mikael Hellström, Jonas Hugosson
No abstract text is available yet for this article.
September 20, 2016: European Urology
https://www.readbyqxmd.com/read/27610197/outcome-of-radical-prostatectomy-in-primary-circulating-prostate-cell-negative-prostate-cancer
#16
Nigel P Murray, Sócrates Aedo, Eduardo Reyes, Cynthia Fuentealba, Omar Jacob
INTRODUCTION: Around 90% of prostate cancers detected using the serum prostate specific antigen (PSA) as a screening test are considered to be localised. However, 20-30% of men treated by radical prostatectomy experience biochemical failure within two years of treatment. The presence of primary circulating prostate cells (CPCs) in the blood of these men implies a dissemination of the tumour and could indicate a greater risk of treatment failure. OBJECTIVE: To evaluate the use of the number of primary CPCs detected before surgery in the prediction of biochemical failure at ten years...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27601997/adenosine-receptor-stimulation-by-polydeoxyribonucleotide-improves-tissue-repair-and-symptomology-in-experimental-colitis
#17
Giovanni Pallio, Alessandra Bitto, Gabriele Pizzino, Federica Galfo, Natasha Irrera, Francesco Squadrito, Giovanni Squadrito, Socrate Pallio, Giuseppe P Anastasi, Giuseppina Cutroneo, Antonio Macrì, Domenica Altavilla
Activation of the adenosine receptor pathway has been demonstrated to be effective in improving tissue remodeling and blunting the inflammatory response. Active colitis is characterized by an intense inflammatory reaction resulting in extensive tissue damage. Symptomatic improvement requires both control of the inflammatory process and repair and remodeling of damaged tissues. We investigated the ability of an A2A receptor agonist, polydeoxyribonucleotide (PDRN), to restore tissue structural integrity in two experimental colitis models using male Sprague-Dawley rats...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27599989/match-of-solubility-parameters-between-oil-and-surfactants-as-a-rational-approach-for-the-formulation-of-microemulsion-with-a-high-dispersed-volume-of-copaiba-oil-and-low-surfactant-content
#18
Francisco Humberto Xavier-Junior, Nicolas Huang, Jean-Jacques Vachon, Vera Lucia Garcia Rehder, Eryvaldo Sócrates Tabosa do Egito, Christine Vauthier
PURPOSE: Aim was to formulate oil-in-water (O/W) microemulsion with a high volume ratio of complex natural oil, i.e. copaiba oil and low surfactant content. The strategy of formulation was based on (i) the selection of surfactants based on predictive calculations of chemical compatibility between their hydrophobic moiety and oil components and (ii) matching the HLB of the surfactants with the required HLB of the oil. METHOD: Solubility parameters of the hydrophobic moiety of the surfactants and of the main components found in the oil were calculated and compared...
September 6, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27577992/malaria-elimination-challenges-in-mesoamerica-evidence-of-submicroscopic-malaria-reservoirs-in-guatemala
#19
Shirley Evelyn Lennon, Adolfo Miranda, Juliana Henao, Andres F Vallejo, Julianh Perez, Alvaro Alvarez, Myriam Arévalo-Herrera, Sócrates Herrera
BACKGROUND: Even though malaria incidence has decreased substantially in Guatemala since 2000, Guatemala remains one of the countries with the highest malaria transmission in Mesoamerica. Guatemala is committed to eliminating malaria as part of the initiative 'Elimination of Malaria in Mesoamerica and the Island of Hispaniola' (EMMIE); however, it is still in the control phase. During the past decade, the government strengthened malaria control activities including mass distribution of long-lasting insecticide-impregnated bed nets, early diagnosis and prompt treatment...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27541303/a-spectral-element-method-with-adaptive-segmentation-for-accurately-simulating-extracellular-electrical-stimulation-of-neurons
#20
Calvin D Eiber, Socrates Dokos, Nigel H Lovell, Gregg J Suaning
The capacity to quickly and accurately simulate extracellular stimulation of neurons is essential to the design of next-generation neural prostheses. Existing platforms for simulating neurons are largely based on finite-difference techniques; due to the complex geometries involved, the more powerful spectral or differential quadrature techniques cannot be applied directly. This paper presents a mathematical basis for the application of a spectral element method to the problem of simulating the extracellular stimulation of retinal neurons, which is readily extensible to neural fibers of any kind...
August 19, 2016: Medical & Biological Engineering & Computing
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