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https://www.readbyqxmd.com/read/29162738/science-and-culture-researchers-find-history-in-the-diagrams-of-euclid-s-elements
#1
Stephen Ornes
No abstract text is available yet for this article.
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29138739/the-euclid-statistical-matrix-tool
#2
EDITORIAL
Curtis Tilves, Saeed Yekaninejad, Tetsuro Hayashi, Eman Eltahlawy, Eugene Shubnikov, Shalkar Adambekov
No abstract text is available yet for this article.
2017: Central Asian Journal of Global Health
https://www.readbyqxmd.com/read/29111727/bioisostere-identification-by-determining-the-amino-acid-binding-preferences-of-common-chemical-fragments
#3
Tomohiro Sato, Noriaki Hashimoto, Teruki Honma
To assist the structural optimization of hit/lead compound during drug discovery, various computational approaches to identify potentially useful bioisosteric conversions have been reported. Here, the preference of chemical fragments to hydrogen bond with specific amino acid residues was used to identify potential bioisosteric conversions. We first compiled a data set of chemical fragments frequently occurring in complex structures contained in Protein Data Bank. We then used a computational approach to determine the amino acids to which these chemical fragments most frequently hydrogen bonded...
November 7, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29068147/r-based-tool-for-a-pairwise-structure-activity-relationship-analysis
#4
Kyrylo Klimenko
The Structure-Activity Relationship analysis is a complex process that can be enhanced by computational techniques. This article describes a simple tool for SAR analysis that has a graphic user interface and a flexible approach towards the input of molecular data. The application allows calculating molecular similarity represented by Tanimoto index & Euclid distance, as well as, determining activity cliffs by means of Structure-Activity Landscape Index. The calculation is performed in a pairwise manner either for the reference compound and other compounds or for all possible pairs in the data set...
October 25, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/29056047/daily-intake-of-chlorogenic-acids-from-consumption-of-mat%C3%A3-ilex-paraguariensis-a-st-hil-traditional-beverages
#5
Karimi Sater Gebara, Arquimedes Gasparotto-Junior, Patricia Gonçalves Santiago, Claudia Andrea Lima Cardoso, Lauro Mera de Souza, Christine Morand, Telma Aparecida Costa, Euclides Lara Cardozo-Junior
The main objective of this study was to investigate the daily intake of chlorogenic acids (CGAs) and methylxanthines by consumers of maté traditional beverages (MTBs), terere and chimarrão (Ilex paraguariensis A.St.-Hill). In the studied population (450 citizens from Toledo, PR, Brazil), 63% consume the chimarrão and 37% terere, with weighted mean daily intakes estimated at 648-2160 and 244-746 mL, respectively. For every 100 mL of beverage consumed, the average amount of total phenol compounds extracted was 673...
November 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29051509/the-transcriptional-regulator-ntrc-controls-glucose-6-phosphate-dehydrogenase-expression-and-polyhydroxybutyrate-synthesis-through-nadph-availability-in-herbaspirillum-seropedicae
#6
Euclides Nenga Manuel Sacomboio, Edson Yu Sin Kim, Henrique Leonardo Ruchaud Correa, Paloma Bonato, Fabio de Oliveira Pedrosa, Emanuel Maltempi de Souza, Leda Satie Chubatsu, Marcelo Müller-Santos
The NTR system is the major regulator of nitrogen metabolism in Bacteria. Despite its broad and well-known role in the assimilation, biosynthesis and recycling of nitrogenous molecules, little is known about its role in carbon metabolism. In this work, we present a new facet of the NTR system in the control of NADPH concentration and the biosynthesis of molecules dependent on reduced coenzyme in Herbaspirillum seropedicae SmR1. We demonstrated that a ntrC mutant strain accumulated high levels of polyhydroxybutyrate (PHB), reaching levels up to 2-fold higher than the parental strain...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28966614/detection-of-increased-plasma-interleukin-6-levels-and-prevalence-of-prevotella-copri-and-bacteroides-vulgatus-in-the-feces-of-type-2-diabetes-patients
#7
Aline Zazeri Leite, Nathália de Campos Rodrigues, Marina Ignácio Gonzaga, João Carlos Cicogna Paiolo, Carolina Arantes de Souza, Nadine Aparecida Vicentini Stefanutto, Wellington Pine Omori, Daniel Guariz Pinheiro, João Luiz Brisotti, Euclides Matheucci Junior, Vânia Sammartino Mariano, Gislane Lelis Vilela de Oliveira
Intestinal dysbiosis and metabolic endotoxemia have been associated with metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes (T2D). The main goal of the present study was to evaluate the intestinal dysbiosis in Brazilian T2D patients and correlate these data with inflammatory cytokines and lipopolysaccharides (LPS) plasma concentrations. This study was approved by the Ethics Committees from Barretos Cancer Hospital and all individuals signed the informed consent form. Stool samples were required for DNA extraction, and the V3/V4 regions of bacterial 16S were sequenced using an Illumina platform...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28899499/mechanisms-underlying-antiatherosclerotic-properties-of-an-enriched-fraction-obtained-from-ilex-paraguariensis-a-st-hil
#8
Patrícia Gonçalves Santiago, Francielly Mourão Gasparotto, Karimi Sater Gebara, Flavia Barbieri Bacha, Francislaine Aparecida Dos Reis Lívero, Maria Angélica Strapazon, Euclides Lara Cardozo Junior, Cândida Aparecida Leite Kassuya, Lauro Mera de Souza, Arquimedes Gasparotto Junior
BACKGROUND: Ilex paraguariensis A. St. Hil. var. paraguariensis (Aquifoliaceae) popularly known as 'mate' is an important species native to South America. Despite numerous studies showing significant antioxidant and lipid lowering properties, the antiatherosclerotic mechanisms of this species remain unknown. PURPOSE: To evaluate the possible antiatherosclerotic effects of a butanolic fraction (n-BFIP) obtained from I. paraguariensis and to investigate the molecular mechanisms involved in this activity...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28887142/marriages-of-mathematics-and-physics-a-challenge-for-biology
#9
REVIEW
Arezoo Islami, Giuseppe Longo
The human attempts to access, measure and organize physical phenomena have led to a manifold construction of mathematical and physical spaces. We will survey the evolution of geometries from Euclid to the Algebraic Geometry of the 20th century. The role of Persian/Arabic Algebra in this transition and its Western symbolic development is emphasized. In this relation, we will also discuss changes in the ontological attitudes toward mathematics and its applications. Historically, the encounter of geometric and algebraic perspectives enriched the mathematical practices and their foundations...
September 5, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28783907/application-of-phytoscreening-to-three-hazardous-waste-sites-in-arizona
#10
Candice M Duncan, Jon Mainhagu, Kayla Virgone, Denise Moreno Ramírez, Mark L Brusseau
The great majority of prior phytoscreening applications have been conducted in humid and temperate environments wherein groundwater is relatively shallow (~1-6m deep). The objective of this research is to evaluate its use in semi-arid environments for sites with deeper groundwater (>10m). To that end, phytoscreening is applied to three chlorinated-solvent hazardous-waste sites in Arizona. Contaminant concentrations were quantifiable in tree-tissue samples collected from two of the sites (Nogales, Park-Euclid)...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28717379/hepatoprotective-effect-of-citral-on-acetaminophen-induced-liver-toxicity-in-mice
#11
Nancy Sayuri Uchida, Saulo Euclides Silva-Filho, Gabriel Fernando Esteves Cardia, Edivaldo Cremer, Francielli Maria de Souza Silva-Comar, Expedito Leite Silva, Ciomar Aparecida Bersani-Amado, Roberto Kenji Nakamura Cuman
High doses of acetaminophen (APAP) lead to acute liver damage. In this study, we evaluated the effects of citral in a murine model of hepatotoxicity induced by APAP. The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) were determined to evaluate the hepatoprotective effects of citral. The livers were used to determine myeloperoxidase (MPO) activity and nitric oxide (NO) production and in histological analysis...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28644245/reply-to-the-letter-to-the-editor-on-effects-of-light-emitting-diode-therapy-on-muscle-hypertrophy-gene-expression-performance-damage-and-delayed-onset-muscle-soreness-case-control-study-with-a-pair-of-identical-twins
#12
Cleber Ferraresi, Danilo Bertucci, Josiane Schiavinato, Rodrigo Reiff, Amélia Araújo, Rodrigo Panepucci, Euclides Matheucci, Anderson F Cunha, Vivian Maria Arakelian, Michael R Hamblin, Nivaldo Parizotto, Vanderlei Bagnato
No abstract text is available yet for this article.
June 21, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28591360/chronic-noncommunicable-diseases-and-population-surveys
#13
EDITORIAL
Euclides Ayres de Castilho, Moisés Goldbaum
No abstract text is available yet for this article.
June 1, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28513858/an-adaptive-fuzzy-c-means-method-utilizing-neighboring-information-for-breast-tumor-segmentation-in-ultrasound-images
#14
Yuan Feng, Fenglin Dong, Xiaolong Xia, Chun-Hong Hu, Qianmin Fan, Yanle Hu, Mingyuan Gao, Sasa Mutic
PURPOSE: Ultrasound (US) imaging has been widely used in breast tumor diagnosis and treatment intervention. Automatic delineation of the tumor is a crucial first step, especially for the computer-aided diagnosis (CAD) and US-guided breast procedure. However, the intrinsic properties of US images such as low contrast and blurry boundaries pose challenges to the automatic segmentation of the breast tumor. Therefore, the purpose of this study is to propose a segmentation algorithm that can contour the breast tumor in US images...
May 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28477240/apuama-a-software-tool-for-reaction-rate-calculations
#15
Henrique O Euclides, Patricia R P Barreto
APUAMA is a free software designed to determine the reaction rate and thermodynamic properties of chemical species of a reagent system. With data from electronic structure calculations, the APUAMA determine the rate constant with tunneling correction, such as Wigner, Eckart and small curvature, and also, include the rovibrational level of diatomic molecules. The results are presented in the form of Arrhenius-Kooij form, for the reaction rate, and the thermodynamic properties are written down in the polynomial form...
June 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28378810/composite-functional-metasurfaces-for-multispectral-achromatic-optics
#16
Ori Avayu, Euclides Almeida, Yehiam Prior, Tal Ellenbogen
Nanostructured metasurfaces offer unique capabilities for subwavelength control of optical waves. Based on this potential, a large number of metasurfaces have been proposed recently as alternatives to standard optical elements. In most cases, however, these elements suffer from large chromatic aberrations, thus limiting their usefulness for multiwavelength or broadband applications. Here, in order to alleviate the chromatic aberrations of individual diffractive elements, we introduce dense vertical stacking of independent metasurfaces, where each layer is made from a different material, and is optimally designed for a different spectral band...
April 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28359199/protective-effect-of-cymbopogon-citratus-essential-oil-in-experimental-model-of-acetaminophen-induced-liver-injury
#17
Nancy Sayuri Uchida, Saulo Euclides Silva-Filho, Rafael Pazinatto Aguiar, Luiz Alexandre Marques Wiirzler, Gabriel Fernando Esteves Cardia, Heitor Augusto Otaviano Cavalcante, Francielli Maria de Souza Silva-Comar, Tânia Cristina Alexandrino Becker, Expedito Leite Silva, Ciomar Aparecida Bersani-Amado, Roberto Kenji Nakamura Cuman
To investigate the hepatoprotective effect of Cymbopogon citratus or lemongrass essential oil (LGO), it was used in an animal model of acute liver injury induced by acetaminophen (APAP). Swiss mice were pretreated with LGO (125, 250 and 500[Formula: see text]mg/kg) and SLM (standard drug, 200[Formula: see text]mg/kg) for a duration of seven days, followed by the induction of hepatotoxicity of APAP (single dose, 250[Formula: see text]mg/kg). The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase were determined to evaluate the hepatoprotective effects of the LGO...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28323011/apocynin-protects-against-neurological-damage-induced-by-quinolinic-acid-by-an-increase-in-glutathione-synthesis-and-nrf2-levels
#18
Silvia Cruz-Álvarez, Ricardo Santana-Martínez, Euclides Avila-Chávez, Diana Barrera-Oviedo, Rogelio Hernández-Pando, José Pedraza-Chaverri, Perla D Maldonado
Apocynin (APO) is a well-known NADPH oxidase (NOX) inhibitor. However, several studies have reported its ability to increase glutathione (GSH) levels. Due to GSH is a major non-enzymatic antioxidant in brain, the aim of this study was to evaluate, in the striatum of control and quinolinic acid (QUIN) injected rats, the effect of APO administration on: (1) GSH levels, (2) activity of some enzymes involved in the GSH metabolism, and (3) nuclear factor erythroid-2-related factor 2 (Nrf2) mRNA levels. Animals received QUIN 240nmol in right striatum and APO (5mg/kg, i...
March 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28205136/a-comparative-study-of-the-risk-profile-of-hemodialysis-patients-in-a-for-profit-network-and-in-two-regional-registries-of-the-italian-society-of-nephrology
#19
Maurizio Postorino, Claudia Amato, Elena Mancini, Paola Carioni, Graziella D'Arrigo, Attilio Di Benedetto, Fabrizio Cerino, Carmela Marino, Antonio Vilasi, Giovanni Tripepi, Stefano Stuard, Giovanbattista Capasso, Antonio Santoro, Carmine Zoccali
In 2013, the Italian Society of Nephrology joined forces with Nephrocare-Italy to create a clinical research cohort of patients on file in the data-rich clinical management system (EUCLID) of this organization for the performance of observational studies in the hemodialysis (HD) population. To see whether patients in EUCLID are representative of the HD population in Italy, we set out to compare the whole EUCLID population with patients included in the regional HD registries in Emilia-Romagna (Northern Italy) and in Calabria (Southern Italy), the sole regions in Italy which have systematically collected an enlarged clinical data set allowing comparison with the data-rich EUCLID system...
February 16, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28099636/use-of-reactive-hyperemia-peripheral-arterial-tonometry-and-circulating-biological-markers-to-predict-outcomes-in-sepsis
#20
Vandack Nobre, Thiago Bragança Ataíde, Luisa Caldeira Brant, Clara Rodrigues Oliveira, Lucas Vieira Rodrigues, Antonio Luiz Pinho Ribeiro, Fernanda Barbosa Lopes, Ivan Euclides Saraiva, Marcus Vinícius Andrade
Objective: To evaluate the usefulness and prognostic value of reactive hyperemia - peripheral arterial tonometry in patients with sepsis. Moreover, we investigated the association of reactive hyperemia - peripheral arterial tonometry results with serum levels of certain inflammatory molecules. Methods: Prospective study, conducted in an 18-bed mixed intensive care unit for adults. The exclusion criteria included severe immunosuppression or antibiotic therapy initiated more than 48 hours before assessment...
October 2016: Revista Brasileira de Terapia Intensiva
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