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REVIEW
Tobore Onojighofia Tobore
Power is an all-pervasive, and fundamental force in human relationships and plays a valuable role in social, political, and economic interactions. Power differences are important in social groups in enhancing group functioning. Most people want to have power and there are many benefits to having power. However, power is a corrupting force and this has been a topic of interest for centuries to scholars from Plato to Lord Acton. Even with increased knowledge of power's corrupting effect and safeguards put in place to counteract such tendencies, power abuse remains rampant in society suggesting that the full extent of this effect is not well understood...
2023: Communicative & Integrative Biology
#22
JOURNAL ARTICLE
Cost-Effectiveness Comparison between Ticagrelor and Clopidogrel in Acute Coronary Syndrome in Iran.
Amir Hashemi-Meshkini, Amirmohammad Tajik, Nayyereh Ayati, Shekoufeh Nikfar, Reza Koochak, Saeed Yaghoubifard, Azam Abbasi, Mehdi Varmaghani
BACKGROUND: The present study aimed to determine the cost-effectiveness of ticagrelor compared with clopidogrel in Iranian patients with acute coronary syndrome (ACS). METHODS: A 1-year decision tree model combined with a 20-year Markov transition model was used to simulate the long-term cost and effectiveness of both ticagrelor and clopidogrel in Iran based on an Iranian payer's perspective. Clinical efficacy data were extracted from the PLATO trial and other published studies...
April 2023: Journal of Tehran Heart Center
#23
JOURNAL ARTICLE
Yujia Sun, Jan Platoš
Polysemy is an inherent characteristic of natural language. In order to make it easier to distinguish between different senses of polysemous words, we propose a method for encoding multiple different senses of polysemous words using a single vector. The method first uses a two-layer bidirectional long short-term memory neural network and a self-attention mechanism to extract the contextual information of polysemous words. Then, a K-means algorithm, which is improved by optimizing the density peaks clustering algorithm based on cosine similarity, is applied to perform word sense induction on the contextual information of polysemous words...
August 9, 2023: Scientific Reports
#24
JOURNAL ARTICLE
Anne Marie Jelsig, Laus Wullum, Tine Plato Kuhlmann, Lilian Bomme Ousager, Johan Burisch, John Gásdal Karstensen
INTRODUCTION: The risk of cancer in patients with solitary colorectal juvenile polyps (JPs) is poorly investigated and several studies have reported polyps with dysplastic and adenomatous alterations. We aimed to investigate the long-term risk of cancer and mortality in these patients by merging data from national registers and comparing them to a matched control cohort. MATERIALS AND METHODS: Patients with a solitary JP were identified in The Danish National Pathology Register and Data Bank (DNPR)...
July 27, 2023: United European Gastroenterology Journal
#25
JOURNAL ARTICLE
Nathan P Goodwin, Robert M Clare, Josephine L Harrington, Anish Badjatiya, Daniel M Wojdyla, Jacob A Udell, Javed Butler, James L Januzzi, Puja B Parikh, Stefan James, John H Alexander, Renato D Lopes, Lars Wallentin, E Magnus Ohman, Adrian F Hernandez, W Schuyler Jones
BACKGROUND: Heart failure (HF) may complicate acute coronary syndrome (ACS) and is associated with a high burden of short- and long-term morbidity and mortality. Only limited data regarding future ischemic events and rehospitalization are available for patients who suffer HF before or during ACS. METHODS: A secondary analysis of 4 large ACS trials (PLATO, APPRAISE-2, TRACER, and TRILOGY ACS) using Cox proportional hazards models was performed to investigate the association of HF status (no HF, chronic HF, de novo HF) at presentation for ACS with all-cause and cardiovascular death, major adverse cardiovascular event (MACE ), myocardial infarction, stroke, and hospitalization for heart failure (HHF) by 1 year...
July 20, 2023: Journal of Cardiac Failure
#26
JOURNAL ARTICLE
Wolfgang Jordan
With reference to a poem "Dialogue between two lovers" and a fable "The Last Love", essential aspects of love are described: love as access to the world, as a path to wisdom, self-knowledge and virtue, love as fear of loss and the desire to merge, love as encounter in dialogue, love as care, love as ecstasy, a feeling of pleasure and happiness. These are based on three theories of love from the beginnings of philosophy in ancient Greece by Plato and Aristotle. In the article they are considered from a philosophical-psychiatric perspective and supplemented by newer interpretations...
July 2023: Psychiatrische Praxis
#27
JOURNAL ARTICLE
Vivek Bedekar, Christopher Neville, Matthew J Tonkin, R Douglas Bartlett, Paul Plato
Solute migration is typically simulated to describe and estimate the fate and transport of contaminants in groundwater. The unit-concentration approach is investigated here as a method to enable solute transport simulations to expand the capabilities of groundwater flow modeling. The unit-concentration method uses a concentration value of one to identify sources of water to be assessed and a concentration of zero for all other water sources. The distribution of concentration thus obtained, unlike particle tracking methods, provides a more intuitive and direct quantification of the contribution of sources reaching various sinks...
June 15, 2023: Ground Water
#28
JOURNAL ARTICLE
Sarah Malanowski, Nicholas R Baima
Many transhumanists see their respective movement as being rooted in ancient ethical thought. However, this alleged connection between the contemporary transhumanist doctrine and the ethical theory of antiquity has come under attack. In this paper, we defend this connection by pointing out a key similarity between the two intellectual traditions. Both traditions are committed to the "radical transformation thesis": ancient ethical theory holds that we should assimilate ourselves to the gods as far as possible, and transhumanists hold that we should enhance ourselves beyond the physical and intellectual parameters of being human so as to become posthuman...
November 21, 2022: Journal of Medicine and Philosophy
#29
REVIEW
Michael Obladen
The 21st century's medicine is predominantly female: two thirds of medical students now are women. In 375 BCE, Plato argued for equal education for male and female professions, explicitly physicians. In Greece and Rome, tombstones testify for patients' gratitude to women physicians. Christianization opened an era of female subordination. When universities established faculties of medicine during the 13th century, women were excluded and had no place where they could study medicine. Since 1850, female medical studies have been debated...
2023: Neonatology
#30
JOURNAL ARTICLE
Thanh N Nguyen, Muhammad M Qureshi, Davide Strambo, Daniel Strbian, Silja Räty, Christian Herweh, Mohamad Abdalkader, Marta Olive-Gadea, Marc Ribo, Marios Psychogios, Urs Fischer, Anh Nguyen, Joji B Kuramatsu, David Haupenthal, Martin Köhrmann, Cornelius Deuschl, Jordi Kühne Escola, Shadi Yaghi, Liqi Shu, Volker Puetz, Daniel P O Kaiser, Johannes Kaesmacher, Adnan Mujanovic, Dominique Cornelius Marterstock, Tobias Engelhorn, Piers Klein, Diogo C Haussen, Mahmoud H Mohammaden, Hend Abdelhamid, Lorena Souza Viana, Bruno Cunha, Isabel Fragata, Michele Romoli, Francesco Diana, Pekka Virtanen, Kimmo Lappalainen, Judith Clark, Stavros Matsoukas, Johanna T Fifi, Sunil A Sheth, Sergio Salazar-Marioni, João Pedro Marto, João Nuno Ramos, Milena Miszczuk, Christoph Riegler, Ashutosh P Jadhav, Shashvat M Desai, Volker Maus, Maximilian Kaeder, Adnan H Siddiqui, Andre Monteiro, Hesham E Masoud, Neil Suryadevara, Maxim Mokin, Shail Thanki, James E Siegler, Jane Khalife, Italo Linfante, Guilherme Dabus, Negar Asdaghi, Vasu Saini, Christian H Nolte, Eberhard Siebert, Thomas R Meinel, Stefanos Finitsis, Markus A Möhlenbruch, Peter A Ringleb, Anne Berberich, Raul G Nogueira, Uta Hanning, Lukas Meyer, Patrik Michel, Simon Nagel
BACKGROUND: The optimal management of patients with isolated posterior cerebral artery occlusion is uncertain. We compared clinical outcomes for endovascular therapy (EVT) versus medical management (MM) in patients with isolated posterior cerebral artery occlusion. METHODS: This multinational case-control study conducted at 27 sites in Europe and North America included consecutive patients with isolated posterior cerebral artery occlusion presenting within 24 hours of time last well from January 2015 to August 2022...
July 2023: Stroke; a Journal of Cerebral Circulation
#31
JOURNAL ARTICLE
Victor L Serebruany, Jean-Francois Tanguay, Milana L Gurvich, Thomas A Marciniak, Dan Atar
BACKGROUND: The incidence of stroke/TIA during annual dual antiplatelet therapy (ADAPT) for acute coronary syndrome (ACS) remains high. Some evidence suggests that shorter than ADAPT may diminish such risk, still providing adequate vascular protection. However, the precise timing of strokes/TIA occurrences during ADAPT is unclear but may be important for determining optimal preventive treatment duration. STUDY QUESTION: The precise timing of secondary cerebrovascular events over ADAPT...
March 29, 2023: American Journal of Therapeutics
#32
JOURNAL ARTICLE
Başak V, Solmaz Ece Yılmaz, Duygu Güçlü
INTRODUCTION: Hatay cuisine has an important place in Turkey and world cuisine. It consists of meat dishes, stuffed vegetables, vegetable dishes, jams, pickles, pilafs, soups, appetizers and salads, herbs collected from nature, desserts, pastries, dairy products and dry foods. The culinary processes differing in cultures alter nutrient value of foods. Food preparation and processing operations affect contents and bioavailability of micronutrients in traditional dishes. Several studies have been carried out to investigate the influence of traditional food preparation and processing methods in vitamins and minerals...
April 26, 2023: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
#33
REVIEW
Svatopluk Civiš, Adam Pastorek, Martin Ferus, Sergei N Yurchenko, Noor-Ines Boudjema
In this study, we present a current state-of-the-art review of middle-to-near IR emission spectra of four simple astrophysically relevant molecular radicals-OH, NH, CN and CH. The spectra of these radicals were measured by means of time-resolved Fourier transform infrared spectroscopy in the 700-7500 cm-1 spectral range and with 0.07-0.02 cm-1 spectral resolution. The radicals were generated in a glow discharge of gaseous mixtures in a specially designed discharge cell. The spectra of short-lived radicals published here are of great importance, especially for the detailed knowledge and study of the composition of exoplanetary atmospheres in selected new planets...
April 11, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#34
JOURNAL ARTICLE
Grażyna Janikowska, Tomasz Janikowski, Marta Plato, Urszula Mazurek, Joanna Orchel, Mieszko Opiłka, Zbigniew Lorenc
Transcriptional analyses such as microarray data have contributed to the progress in the diagnostics and therapy of colorectal cancer (CRC). The need for such research is still present because of the disease being common in both men and women with a high second position in cancer rankings. Little is known about the relations between the histaminergic system and inflammation in the large intestine and CRC. Therefore, the aim of this study was to evaluate the expression of genes related to the histaminergic system and inflammation in the CRC tissues at three cancer development designs: all tested CRC samples, low (LCS) and high (HCS) clinical stage, and four clinical stages (CSI-CSIV), to the control...
March 3, 2023: International Journal of Molecular Sciences
#35
JOURNAL ARTICLE
Pia Davidsson, Susanna Eketjäll, Niclas Eriksson, Anna Walentinsson, Richard C Becker, Anders Cavallin, Anna Bogstedt, Anna Collén, Claes Held, Stefan James, Agneta Siegbahn, Ralph Stewart, Robert S Storey, Harvey White, Lars Wallentin
AIMS: The vascular endothelial growth factor (VEGF) family is involved in pathophysiological mechanisms underlying cardio vascular (CV) diseases. The aim of this study was to investigate the associations between circulating VEGF ligands and/or soluble receptors and CV outcome in patients with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS). METHODS AND RESULTS: Levels of VEGF biomarkers, including bFGF, Flt-1, KDR (VEGFR2), PlGF, Tie-2, VEGF-A, VEGF-C, and VEGF-D, were measured in the PLATO ACS cohort (n = 2,091, discovery cohort)...
March 3, 2023: Cardiovascular Research
#36
JOURNAL ARTICLE
Victor L Serebruany, Jean-Francois Tanguay, Milana L Gurvich, Thomas A Marciniak, Dan Atar
BACKGROUND: Excess mortality remains the cornerstone concern despite dual antiplatelet therapy after acute coronary syndrome. Some data suggest that shorter periods than 12 months of DAPT diminish bleeding risks, yet still providing adequate vascular protection and improving survival. However, the precise timing of deaths after acute coronary syndrome has not been mapped in many studies. This knowledge may be critical for defining optimal treatment duration. METHODS: Access was gained to the FDA-issued Platelet Inhibition and Outcomes (PLATO) trial dataset in which post hoc analyses of timing of death events during DAPT (with either aspirin/ticagrelor or aspirin/clopidogrel) were performed...
February 22, 2023: American Journal of Medicine
#37
EDITORIAL
Francesco Prati, Flavio Giuseppe Biccirè
No abstract text is available yet for this article.
February 28, 2023: Journal of the American College of Cardiology
#38
JOURNAL ARTICLE
Susanne Weininger, Malte Neudorf, Stefan Gröger, Eric Plato, Robert Broneske, Kay Saalwächter, Ulrich Weininger, Jochen Balbach
In the human eye lenses, the crystallin proteins facilitate transparency, light refraction, as well as UV light protection. A deregulated balanced interplay between α-, β-, and γ-crystallin can causes cataract. γD-crystallin (hγD) is involved in the energy dissipation of absorbed UV light by energy transfer between aromatic side chains. We studied early UV-B induced damage of hγD with molecular resolution by solution NMR and fluorescence spectroscopy. hγD modifications were restricted to Tyr 17 and Tyr 29 in the N-terminal domain, where we observed a local unfolding of the hydrophobic core...
February 21, 2023: Macromolecular Bioscience
#39
JOURNAL ARTICLE
Andrea Calcaterra, Francesca Polli, Lara Lamelza, Cristina Del Plato, Silvia Cammarone, Francesca Ghirga, Bruno Botta, Franco Mazzei, Deborah Quaglio
In recent years, several efforts have been made to develop selective, sensitive, fast response, and miniaturized immunosensors with improved performance for the monitoring and screening of analytes in several matrices, significantly expanding the use of this technology in a broad range of applications. However, one of the main technical challenges in developing immunosensors is overcoming the complexity of binding antibodies (Abs) to the sensor surface. Most immobilizing approaches lead to a random orientation of Abs, resulting in lower binding site density and immunoaffinity...
February 8, 2023: Bioconjugate Chemistry
#40
JOURNAL ARTICLE
How to construct liquid-crystal spectacles to control vision of real-world objects and environments.
Michael A Gomez, Jacqueline C Snow
A major challenge in studying naturalistic vision lies in controlling stimulus and scene viewing time. This is especially the case for studies using real-world objects as stimuli (rather than computerized images) because real objects cannot be "onset" and "offset" in the same way that images can be. Since the late 1980s, one solution to this problem has been to have the observer wear electro-optic spectacles with computer-controlled liquid-crystal lenses that switch between transparent ("open") and translucent ("closed") states...
February 3, 2023: Behavior Research Methods
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