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https://www.readbyqxmd.com/read/27899747/ticagrelor-in-acute-stroke-or-transient-ischemic-attack-in-asian-patients-from-the-socrates-trial-acute-stroke-or-transient-ischemic-attack-treated-with-aspirin-or-ticagrelor-and-patient-outcomes
#1
Yongjun Wang, Kazuo Minematsu, Ka Sing Lawrence Wong, Pierre Amarenco, Gregory W Albers, Hans Denison, J Donald Easton, Scott R Evans, Peter Held, Jenny Jonasson, Carlos A Molina, S Claiborne Johnston
BACKGROUND AND PURPOSE: In the SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), ticagrelor was not superior to aspirin. Because of differences in patient demographics and stroke disease pattern in Asia, outcomes of ticagrelor versus aspirin were assessed among Asian patients in a prespecified exploratory analysis. METHODS: Baseline demographics, treatment effects, and safety of ticagrelor and aspirin were assessed among Asian patients...
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27876521/increased-risk-of-renal-dysfunction-with-percutaneous-mechanical-thrombectomy-compared-with-catheter-directed-thrombolysis
#2
Katherine L Morrow, Ann H Kim, Steven A Plato, Andrew J Shevitz, Jerry Goldstone, Henry Baele, Vikram S Kashyap
OBJECTIVE: Percutaneous mechanical thrombectomy (PMT) is regularly used in the treatment of both venous and arterial thrombosis. Although there has been no formal report, PMT has been linked to cases of reversible postoperative acute kidney injury (AKI). The purpose of this study is to evaluate the risk of renal dysfunction in patients undergoing PMT vs catheter-directed thrombolysis (CDT) for treatment of an acute thrombus. METHODS: This study is a retrospective review of all patients in a single institution with a Current Procedural Terminology code for PMT or CDT from January 2009 through December 2014...
November 19, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27873425/i-want-you-to-pretend-to-be-sincere
#3
Julia Hynes
Medical education has changed dramatically since the inception of this journal 50 years ago and is indeed a work in progress: there is now heavy emphasis on the character of the physician, in particular, and professionalism, in general. The subjects of communications skills and the teaching of sincerity, empathy and compassion are relative newcomers to the stage: they are not even as old as this journal itself. Nevertheless, these topics arose in an ancient debate dating from classical antiquity. 'Can we teach virtue?' Plato wondered in the Meno...
December 2016: Medical Education
https://www.readbyqxmd.com/read/27867992/tumor-vaccines-and-cellular-immunotherapies
#4
EDITORIAL
John Nemunaitis, Neil Senzer, Leah Plato
No abstract text is available yet for this article.
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27866405/occupation-and-mesothelioma-in-sweden-updated-incidence-in-men-and-women-in-the-27-years-after-the-asbestos-ban
#5
Nils Plato, Jan Ivar Martinsen, Pär Sparén, Gunnar Hillerdal, Elisabete Weiderpass
OBJECTIVES: We updated the Swedish component of the Nordic Occupational Cancer (NOCCA) Study through 2009 in order to investigate the incidence of mesothelioma of the peritoneum and pleura in both genders, and explored occupational exposures that may be associated with mesothelioma. METHODS: The Swedish component of the NOCCA Study includes 6.78 million individuals. Data from this cohort were linked to the population-based Swedish Cancer Registry and Swedish Total Population Registry for three periods between 1961 and 2009, and then further linked to the Swedish NOCCA job-exposure matrix, which includes 25 carcinogenic substances and the corresponding exposure levels for 280 occupations...
2016: Epidemiology and Health
https://www.readbyqxmd.com/read/27789557/the-dogged-search-for-cryptic-effects-of-ticagrelor-wishful-thinking-or-real-benefits-beyond-p2y12-inhibition
#6
Paul A Gurbel, Young-Hoon Jeong, Udaya Tantry
Greater protection against ischemic event occurrences has been associated with lower levels of platelet reactivity to adenosine diphosphate in patients with high risk coronary artery disease (1-3). The latter observations serve as the basis of the "platelet hypothesis"- i.e. greater inhibition of P2Y12 =less thrombotic event occurrence (4). Ticagrelor, a cyclo-pentyl-triazolo-pyrimidine, is indisputably a more potent P2Y12 inhibitor than clopidogrel (5) and when administered to patients with acute coronary syndrome (ACS) in the PLATelet inhibition and patient Outcomes (PLATO) trial resulted in a reduction not only in myocardial infarction (MI) but also, vascular death as compared to clopidogrel (6)...
October 27, 2016: Circulation
https://www.readbyqxmd.com/read/27763370/2013-arthur-o-lovejoy-lecture-a-cognitive-history-of-divination-in-ancient-greece
#7
Peter T Struck
Ancient Greeks drew advice from oracles, dreams, entrails, the movements of birds, sneezes, and myriad other sources for divination. Classicists typically study such phenomena as examples of occult religion, or for their use as a social mechanism for managing dissent and forging consensus. Ancient philosophical accounts by contrast go a longer way toward considering them seriously, on their own terms. They take them as an invitation into developing speculative accounts of non-standard epistemological schemes...
2016: Journal of the History of Ideas
https://www.readbyqxmd.com/read/27740874/current-controversies-in-the-use-of-aspirin-and-ticagrelor-for-the-treatment-of-thrombotic-events
#8
Aung Myat, Udaya S Tantry, Jacek Kubica, Paul A Gurbel
A P2Y12 inhibitor plus aspirin is the most widely used antiplatelet strategy to prevent adverse outcomes in the setting of atherothrombotic vascular disease. Areas covered: A paucity of robust evidence for an optimal dose, gastrointestinal toxicity, ineffectiveness in high-risk patients and interactions with other antiplatelet agents, are major controversies associated with aspirin therapy. Ticagrelor is a reversibly binding oral P2Y12 receptor blocker that mediates potent inhibition of adenosine diphosphate-induced platelet function...
December 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27735912/-budget-impact-analysis-of-antiplatelet-therapy-with-ticagrelor-and-clopidogrel-in-patients-with-acute-coronary-syndrome-after-coronary-artery-bypass-surgery
#9
S K Zyryanov, D Yu Belousov, E V Afanas'eva, E V Dumchenko
AIM: Clinical and economic examinations were made to study whether it is appropriate to use antiplatelet therapy (APT) with ticagrelor in combination with acetylsalicylic acid (ASA) versus a combination of clopidogrel and ASA in patients with acute coronary syndrome (ACS) following coronary artery bypass surgery (CABS). MATERIAL AND METHODS: A budget impact analysis was used. Data on the efficiency and safety of APT were taken from a relevant analysis in the subgroups of the randomized controlled trial PLATO...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27715344/pharmacokinetics-and-pharmacodynamics-of-ticagrelor-in-the-treatment-of-cardiac-ischemia
#10
Gian Marco Rosa, Daniele Bianco, Alberto Valbusa, Laura Massobrio, Francesco Chiarella, Claudio Brunelli
After acute coronary syndromes (ACS), the so-called dual antiplatelet therapy (DAPT), which usually consists of low-dose of aspirin in combination with a thienopyridine (clopidogrel, prasugrel) or with a cyclopentyltriazolopyrimidine (ticagrelor), reduces the risk of ischemic events. Ticagrelor, un particular, is an effective drug as it isn' a prodrug, doesn't require metabolic activation and demonstrates a rapid onset and faster offset of action. Areas covered: This article evaluates the pharmacokinetics, efficacy, safety and tolerability of ticagrelor during DAPT after ACS and its potential use beyond the canonical twelve months after PCI...
December 2016: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27685113/dosimetric-impact-of-cylinder-size-in-high-dose-rate-vaginal-cuff-brachytherapy-vcbt-for-primary-endometrial-cancer
#11
Hualin Zhang, Mahesh Gopalakrishnan, Plato Lee, Zhuang Kang, Vythialingam Sathiaseelan
The purpose of this study was to evaluate the dosimetric impact of cylinder size in high-dose-rate (HDR) vaginal cuff brachytherapy (VCBT). Sample plans of HDR VCBT in a list of cylinders ranging from 2.5 to 4 cm in diameter at 0.5 cm incre-ment were created and analyzed. The doses were prescribed either at the 0.5cm depth with 5.5 Gy for 4 fractions or at the cylinder surface with 8.8 Gy for 4 frac-tions, in various treatment lengths. A 0.5 cm shell volume called PTV_Eval was contoured for each plan and served as the target volume for dosimetric evaluation...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27673946/the-development-of-an-umbrella-trial-plato-to-address-radiation-therapy-dose-questions-in-the-locoregional-management-of-squamous-cell-carcinoma-of-the-anus
#12
D Sebag-Montefiore, R Adams, S Bell, L Berkman, D C Gilbert, R Glynne-Jones, V Goh, W Gregory, M Harrison, L A Kachnic, M T Lee, L McParland, R Muirhead, B D O'Neill, G G Hutchins, S Rao, A Renehan, A Smith, G Velikova, M A Hawkins
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27658463/occupation-and-mesothelioma-in-sweden-updated-incidence-for-men-and-women-up-to-27-years-after-asbestos-ban
#13
Nils Plato, Jan Ivar Martinsen, Pär Sparén, Gunnar Hillerdal, Elisabete Weiderpass
Objectives: We updated the Swedish component of the Nordic Occupational Cancer (NOCCA) Study through 2009 in order to investigate the incidence of mesothelioma of the peritoneum and pleura in both sexes, and explored occupational exposures that may be associated with mesothelioma. Methods: The Swedish component of the NOCCA Study includes 6.78 million individuals. Data from this cohort was linked to the population-based Swedish Cancer Registry and Swedish Total Population Registry for three periods between 1961 and 2009 and then further linked to the Swedish NOCCA Job Exposure Matrix, which includes 25 carcinogenic substances and corresponding exposure levels for 280 occupations...
September 20, 2016: Epidemiology and Health
https://www.readbyqxmd.com/read/27625109/higher-rates-of-triple-class-virological-failure-in-perinatally-hiv-infected-teenagers-compared-with-heterosexually-infected-young-adults-in-europe
#14
A Judd, R Lodwick, A Noguera-Julian, D M Gibb, K Butler, D Costagliola, C Sabin, A van Sighem, B Ledergerber, C Torti, A Mocroft, D Podzamczer, M Dorrucci, S De Wit, N Obel, F Dabis, A Cozzi-Lepri, F García, N H Brockmeyer, J Warszawski, M I Gonzalez-Tome, C Mussini, G Touloumi, R Zangerle, J Ghosn, A Castagna, G Fätkenheuer, C Stephan, L Meyer, M A Campbell, G Chene, A Phillips
OBJECTIVES: The aim of the study was to determine the time to, and risk factors for, triple-class virological failure (TCVF) across age groups for children and adolescents with perinatally acquired HIV infection and older adolescents and adults with heterosexually acquired HIV infection. METHODS: We analysed individual patient data from cohorts in the Collaboration of Observational HIV Epidemiological Research Europe (COHERE). A total of 5972 participants starting antiretroviral therapy (ART) from 1998, aged < 20 years at the start of ART for those with perinatal infection and 15-29 years for those with heterosexual infection, with ART containing at least two nucleoside reverse transcriptase inhibitors (NRTIs) and a nonnucleoside reverse transcriptase inhibitor (NNRTI) or a boosted protease inhibitor (bPI), were followed from ART initiation until the most recent viral load (VL) measurement...
September 14, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27605392/studies-of-the-interaction-of-ticagrelor-with-the-p2y13-receptor-and-with-p2y13-dependent-pro-platelet-formation-by-human-megakaryocytes
#15
Anna Björquist, Christian A Di Buduo, Eti A Femia, Robert F Storey, Richard C Becker, Alessandra Balduini, Sven Nylander, Marco Cattaneo
Ticagrelor is an antagonist of the platelet P2Y12 receptor for ADP, approved for the prevention of thromboembolic events in patients with acute coronary syndrome. Previous studies showed that ticagrelor has no significant activity versus P1 receptors for adenosine and other known P2Y receptors, with the exception of P2Y13, which was not tested. The P2Y12 antagonist cangrelor has been shown to also inhibit P2Y13 and to decrease the P2Y13-regulated capacity of megakaryocytes to produce pro-platelets. We tested whether or not ticagrelor inhibits P2Y13 signalling and function...
November 30, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27576432/quantifying-target-specific-motion-in-anal-cancer-patients-treated-with-intensity-modulated-radiotherapy-imrt
#16
Lisa Durrant, Maxwell Robinson, Maria A Hawkins, Frank Van den Heuvel, Rebecca Muirhead
BACKGROUND AND PURPOSE: Intensity modulated radiotherapy requires all target areas to be treated by a single radiotherapy plan. In anal cancer, the pelvic nodes, inguinal nodes and primary tumour represent three different targets. We aim to calculate target-specific motion in anal cancer radiotherapy, when delivered using a single pelvic online auto-match. MATERIALS AND METHODS: Twenty consecutive patients treated using IMRT at a single institution were studied...
October 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27526785/mir-625-3p-regulates-oxaliplatin-resistance-by-targeting-map2k6-p38-signalling-in-human-colorectal-adenocarcinoma-cells
#17
Mads Heilskov Rasmussen, Iben Lyskjær, Rosa Rakownikow Jersie-Christensen, Line Schmidt Tarpgaard, Bjarke Primdal-Bengtson, Morten Muhlig Nielsen, Jakob Skou Pedersen, Tine Plato Hansen, Flemming Hansen, Jesper Velgaard Olsen, Per Pfeiffer, Torben Falck Ørntoft, Claus Lindbjerg Andersen
Oxaliplatin resistance in colorectal cancers (CRC) is a major medical problem, and predictive markers are urgently needed. Recently, miR-625-3p was reported as a promising predictive marker. Herein, we show that miR-625-3p functionally induces oxaliplatin resistance in CRC cells, and identify the signalling networks affected by miR-625-3p. We show that the p38 MAPK activator MAP2K6 is a direct target of miR-625-3p, and, accordingly, is downregulated in non-responder patients of oxaliplatin therapy. miR-625-3p-mediated resistance is reversed by anti-miR-625-3p treatment and ectopic expression of a miR-625-3p insensitive MAP2K6 variant...
2016: Nature Communications
https://www.readbyqxmd.com/read/27516703/the-history-of-melancholia-disease
#18
Abbas Sadeghfard, Ali Reza Bozorgi, Shaghayegh Ahmadi, Masoumeh Shojaei
BACKGROUND: Melancholia is a kind of depression with the most common symptoms of evident mental disorder, slimness, lack of enjoyment, feeling guilty and having no appetite. In modern medicine, the word "melancholia" only refers to mental and affective symptoms of depression. However, historically, it could have physical symptoms as well as mental symptoms and the atrabilious situations were categorized according to their common reasons rather than their specific characteristics. This study aimed to enlighten the history of this disease...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27504183/is-medical-perspective-on-clinical-governance-practices-associated-with-clinical-units-performance-and-mortality-a-cross-sectional-study-through-a-record-linkage-procedure
#19
Guido Sarchielli, Giovanni De Plato, Mario Cavalli, Stefano Albertini, Ilaria Nonni, Lucia Bencivenni, Arianna Montali, Antonio Ventura, Francesca Montali
OBJECTIVE: Assessment of the knowledge and application as well as perceived utility by doctors of clinical governance tools in order to explore their impact on clinical units' performance measured through mortality rates and efficiency indicators. METHODS: This research is a cross-sectional study with a deterministic record-linkage procedure. The sample includes n = 1250 doctors (n = 249 chiefs of clinical units; n = 1001 physicians) working in six public hospitals located in the Emilia-Romagna Region in Italy...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/27437658/sudden-cardiac-death-after-non-st-segment-elevation-acute-coronary-syndrome
#20
Paul L Hess, Daniel M Wojdyla, Sana M Al-Khatib, Yuliya Lokhnygina, Lars Wallentin, Paul W Armstrong, Matthew T Roe, E Magnus Ohman, Robert A Harrington, John H Alexander, Harvey D White, Frans Van de Werf, Jonathan P Piccini, Claes Held, Philip E Aylward, David J Moliterno, Kenneth W Mahaffey, Pierluigi Tricoci
IMPORTANCE: In the current therapeutic era, the risk for sudden cardiac death (SCD) after non-ST-segment elevation acute coronary syndrome (NSTE ACS) has not been characterized completely. OBJECTIVE: To determine the cumulative incidence of SCD during long-term follow-up after NSTE ACS, to develop a risk model and risk score for SCD after NSTE ACS, and to assess the association between recurrent events after the initial ACS presentation and the risk for SCD. DESIGN, SETTING, AND PARTICIPANTS: This pooled cohort analysis merged individual data from 48 286 participants in 4 trials: the Apixaban for Prevention of Acute Ischemic Events 2 (APPRAISE-2), Study of Platelet Inhibition and Patient Outcomes (PLATO), Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER), and Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trials...
April 1, 2016: JAMA Cardiology
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