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https://www.readbyqxmd.com/read/28093761/soul-in-the-world-symbolic-culture-as-the-medium-for-psyche
#1
Warren Colman
Whilst the loss of a sense of living connection with the material world is mainly associated with the scientific revolution in seventeenth century Europe, it can be traced back to Plato's introduction of a hierarchy between soul and body. Jung's attempted solution to this - esse in anima - is ingenious but maintains the Cartesian split by which the aliveness of the world is reduced to a projection of psychic forces (the archetypes). An alternative approach is proposed, rooted in the Aristotelean emphasis on practical activity that sees the soul as a function of our way of being in the world...
February 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28024656/validation-of-bleeding-classifications-in-coronary-artery-bypass-grafting
#2
Debora Brascia, Daniel Reichart, Francesco Onorati, Andrea Perrotti, Vito G Ruggieri, Karl Bounader, Jean Philippe Verhoye, Giuseppe Santarpino, Theodor Fischlein, Daniele Maselli, Carmelo Dominici, Giovanni Mariscalco, Riccardo Gherli, Antonino S Rubino, Marisa De Feo, Ciro Bancone, Giuseppe Gatti, Francesco Santini, Magnus Dalén, Matteo Saccocci, Giuseppe Faggian, Tuomas Tauriainen, Eeva-Maija Kinnunen, Francesco Nicolini, Tiziano Gherli, Stefano Rosato, Fausto Biancari
Perioperative bleeding is a determinant of poor outcome in patients undergoing coronary artery bypass grafting (CABG), but there is a lack of adequate stratification of its severity. The ability of the European registry of Coronary Artery Bypass Grafting (E-CABG), Universal Definition of Perioperative Bleeding (UDPB), Study of Platelet Inhibition and Patient Outcomes (PLATO), Clopidogrel and Aspirin Optimal Dose Usage to Reduce Recurrent Events-Seventh Organization to Assess Strategies in Ischemic Syndromes (CURRENT-OASIS 7), Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q Wave Coronary Events (ESSENCE), and SafeTy and Efficacy of Enoxaparin in Percutaneous coronary intervention patients, an internationaL randomized Evaluation (STEEPLE) bleeding classifications to predict early mortality, stroke, acute kidney injury (AKI) stage 3, and deep sternal wound infection/mediastinitis was investigated in 3,730 patients from the prospective, multicentre E-CABG registry...
December 3, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28008283/validation-of-celiac-disease-diagnoses-recorded-in-the-danish-national-patient-register-using-duodenal-biopsies-celiac-disease-specific-antibodies-and-human-leukocyte-antigen-genotypes
#3
Stine Dydensborg Sander, Ketil Størdal, Tine Plato Hansen, Anne-Marie Nybo Andersen, Joseph A Murray, Søren Thue Lillevang, Steffen Husby
PURPOSE: The purpose of this study was to validate the celiac disease diagnoses recorded in the Danish National Patient Register. To validate the diagnoses, we used information on duodenal biopsies from a national register of pathology reports (the Patobank) and information on celiac disease-specific antibodies and human leukocyte antigen (HLA) genotypes obtained from patient medical records. PATIENTS AND METHODS: We included all the children who were born from 1995 to 2012 and who were registered as having celiac disease in the Danish National Patient Register...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/28007809/the-implications-of-meno-s-paradox-for-the-mental-capacity-act-2005
#4
Paul Skowron
Meno's paradox-which asks 'how will you know it is the thing you didn't know?'-appears in Plato's dialogue of the same name. This article suggests that a similar question arises in some supportive relationships. Attention to this question clarifies one condition necessary to justify making a best interests decisions against someone's will: the decided-for person must be unable to recognise that they have failed to recognise a need. From this condition, two duties are derived: a duty to ensure that someone cannot recognise that they have failed to recognise a need before making a decision against their will; and a duty to provide consensual support to those who have had decisions made against their will, in order to help them to avoid such second-order failures of recognition in the future...
2016: Medical Law Review
https://www.readbyqxmd.com/read/27935774/communication-in-the-operating-room-setting
#5
Lisa Osborne-Smith, R Kyle Hodgen
Ideal and effective communication consists of a clear, audible, and focused message from a transmitter that is delivered to an attentive, undistracted receiver, and consists of both verbal and nonverbal types. Communication in the health care setting is highly complex and dynamic, involving multiple settings, participants, and unique challenges. Effective communication in the perioperative environment is a requirement for safe patient care delivery and an important element of teamwork. A message must be accurately delivered in a uniquely high-risk and time-sensitive location, beset with numerous distractions, barriers, and challenges...
January 2017: Annual Review of Nursing Research
https://www.readbyqxmd.com/read/27932413/biomarkers-and-coronary-lesions-predict-outcomes-after-revascularization-in-non-st-elevation-acute-coronary-syndrome
#6
Daniel Lindholm, Stefan K James, Maria Bertilsson, Richard C Becker, Christopher P Cannon, Evangelos Giannitsis, Robert A Harrington, Anders Himmelmann, Frederic Kontny, Agneta Siegbahn, Philippe Gabriel Steg, Robert F Storey, Matthijs A Velders, W Douglas Weaver, Lars Wallentin
BACKGROUND: Risk stratification in non-ST-elevation acute coronary syndrome (NSTE-ACS) is currently mainly based on clinical characteristics. With routine invasive management, angiography findings and biomarkers are available and may improve prognostication. We aimed to assess if adding biomarkers [high-sensitivity cardiac troponin T (cTnT-hs), N-terminal probrain-type natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15)] and extent of coronary artery disease (CAD) might improve prognostication in revascularized patients with NSTE-ACS...
December 8, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27917711/theories-about-blood-coagulation-in-the-writings-of-ancient-greek-medico-philosophers
#7
Gregory Tsoucalas, Marianna Karamanou, Theodoros G Papaioannou, Markos Sgantzos
Anaxagoras and Empedocles both established during the Presocratic era a pioneering theory for the creation of everything in the universe. Macrocosmos' impact through the "Four Elements Theory" explained the conglomeration of the blood inside the vessels. Hippocrates, who instituted the "Four Humours theory", clearly understood blood's coagulation and introduced the term "thrombus". Plato, Aristotle and Galen, all engaged with the clotting phenomenon trying to interpret it. After eons of inquiry, it was the innovative thinking of the ancient Greek medico philosophers that set the scientific bases towards the understanding of a process that had been analyzing until our era...
December 5, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27899747/ticagrelor-in-acute-stroke-or-transient-ischemic-attack-in-asian-patients-from-the-socrates-trial-acute-stroke-or-transient-ischemic-attack-treated-with-aspirin-or-ticagrelor-and-patient-outcomes
#8
Yongjun Wang, Kazuo Minematsu, Ka Sing Lawrence Wong, Pierre Amarenco, Gregory W Albers, Hans Denison, J Donald Easton, Scott R Evans, Peter Held, Jenny Jonasson, Carlos A Molina, S Claiborne Johnston
BACKGROUND AND PURPOSE: In the SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), ticagrelor was not superior to aspirin. Because of differences in patient demographics and stroke disease pattern in Asia, outcomes of ticagrelor versus aspirin were assessed among Asian patients in a prespecified exploratory analysis. METHODS: Baseline demographics, treatment effects, and safety of ticagrelor and aspirin were assessed among Asian patients...
January 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27876521/increased-risk-of-renal-dysfunction-with-percutaneous-mechanical-thrombectomy-compared-with-catheter-directed-thrombolysis
#9
Katherine L Morrow, Ann H Kim, Steven A Plato, Andrew J Shevitz, Jerry Goldstone, Henry Baele, Vikram S Kashyap
OBJECTIVE: Percutaneous mechanical thrombectomy (PMT) is regularly used in the treatment of both venous and arterial thrombosis. Although there has been no formal report, PMT has been linked to cases of reversible postoperative acute kidney injury (AKI). The purpose of this study is to evaluate the risk of renal dysfunction in patients undergoing PMT vs catheter-directed thrombolysis (CDT) for treatment of an acute thrombus. METHODS: This study is a retrospective review of all patients in a single institution with a Current Procedural Terminology code for PMT or CDT from January 2009 through December 2014...
November 19, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27873425/i-want-you-to-pretend-to-be-sincere
#10
Julia Hynes
Medical education has changed dramatically since the inception of this journal 50 years ago and is indeed a work in progress: there is now heavy emphasis on the character of the physician, in particular, and professionalism, in general. The subjects of communications skills and the teaching of sincerity, empathy and compassion are relative newcomers to the stage: they are not even as old as this journal itself. Nevertheless, these topics arose in an ancient debate dating from classical antiquity. 'Can we teach virtue?' Plato wondered in the Meno...
December 2016: Medical Education
https://www.readbyqxmd.com/read/27867992/tumor-vaccines-and-cellular-immunotherapies
#11
EDITORIAL
John Nemunaitis, Neil Senzer, Leah Plato
No abstract text is available yet for this article.
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27866405/occupation-and-mesothelioma-in-sweden-updated-incidence-in-men-and-women-in-the-27-years-after-the-asbestos-ban
#12
Nils Plato, Jan Ivar Martinsen, Pär Sparén, Gunnar Hillerdal, Elisabete Weiderpass
OBJECTIVES: We updated the Swedish component of the Nordic Occupational Cancer (NOCCA) Study through 2009 in order to investigate the incidence of mesothelioma of the peritoneum and pleura in both genders, and explored occupational exposures that may be associated with mesothelioma. METHODS: The Swedish component of the NOCCA Study includes 6.78 million individuals. Data from this cohort were linked to the population-based Swedish Cancer Registry and Swedish Total Population Registry for three periods between 1961 and 2009, and then further linked to the Swedish NOCCA job-exposure matrix, which includes 25 carcinogenic substances and the corresponding exposure levels for 280 occupations...
2016: Epidemiology and Health
https://www.readbyqxmd.com/read/27789557/the-dogged-search-for-cryptic-effects-of-ticagrelor-wishful-thinking-or-real-benefits-beyond-p2y12-inhibition
#13
EDITORIAL
Paul A Gurbel, Young-Hoon Jeong, Udaya S Tantry
No abstract text is available yet for this article.
November 29, 2016: Circulation
https://www.readbyqxmd.com/read/27763370/2013-arthur-o-lovejoy-lecture-a-cognitive-history-of-divination-in-ancient-greece
#14
Peter T Struck
Ancient Greeks drew advice from oracles, dreams, entrails, the movements of birds, sneezes, and myriad other sources for divination. Classicists typically study such phenomena as examples of occult religion, or for their use as a social mechanism for managing dissent and forging consensus. Ancient philosophical accounts by contrast go a longer way toward considering them seriously, on their own terms. They take them as an invitation into developing speculative accounts of non-standard epistemological schemes...
2016: Journal of the History of Ideas
https://www.readbyqxmd.com/read/27740874/current-controversies-in-the-use-of-aspirin-and-ticagrelor-for-the-treatment-of-thrombotic-events
#15
Aung Myat, Udaya S Tantry, Jacek Kubica, Paul A Gurbel
A P2Y12 inhibitor plus aspirin is the most widely used antiplatelet strategy to prevent adverse outcomes in the setting of atherothrombotic vascular disease. Areas covered: A paucity of robust evidence for an optimal dose, gastrointestinal toxicity, ineffectiveness in high-risk patients and interactions with other antiplatelet agents, are major controversies associated with aspirin therapy. Ticagrelor is a reversibly binding oral P2Y12 receptor blocker that mediates potent inhibition of adenosine diphosphate-induced platelet function...
December 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27735912/-budget-impact-analysis-of-antiplatelet-therapy-with-ticagrelor-and-clopidogrel-in-patients-with-acute-coronary-syndrome-after-coronary-artery-bypass-surgery
#16
S K Zyryanov, D Yu Belousov, E V Afanas'eva, E V Dumchenko
AIM: Clinical and economic examinations were made to study whether it is appropriate to use antiplatelet therapy (APT) with ticagrelor in combination with acetylsalicylic acid (ASA) versus a combination of clopidogrel and ASA in patients with acute coronary syndrome (ACS) following coronary artery bypass surgery (CABS). MATERIAL AND METHODS: A budget impact analysis was used. Data on the efficiency and safety of APT were taken from a relevant analysis in the subgroups of the randomized controlled trial PLATO...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27715344/pharmacokinetics-and-pharmacodynamics-of-ticagrelor-in-the-treatment-of-cardiac-ischemia
#17
Gian Marco Rosa, Daniele Bianco, Alberto Valbusa, Laura Massobrio, Francesco Chiarella, Claudio Brunelli
After acute coronary syndromes (ACS), the so-called dual antiplatelet therapy (DAPT), which usually consists of low-dose of aspirin in combination with a thienopyridine (clopidogrel, prasugrel) or with a cyclopentyltriazolopyrimidine (ticagrelor), reduces the risk of ischemic events. Ticagrelor, un particular, is an effective drug as it isn' a prodrug, doesn't require metabolic activation and demonstrates a rapid onset and faster offset of action. Areas covered: This article evaluates the pharmacokinetics, efficacy, safety and tolerability of ticagrelor during DAPT after ACS and its potential use beyond the canonical twelve months after PCI...
December 2016: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27685113/dosimetric-impact-of-cylinder-size-in-high-dose-rate-vaginal-cuff-brachytherapy-vcbt-for-primary-endometrial-cancer
#18
Hualin Zhang, Mahesh Gopalakrishnan, Plato Lee, Zhuang Kang, Vythialingam Sathiaseelan
The purpose of this study was to evaluate the dosimetric impact of cylinder size in high-dose-rate (HDR) vaginal cuff brachytherapy (VCBT). Sample plans of HDR VCBT in a list of cylinders ranging from 2.5 to 4 cm in diameter at 0.5 cm incre-ment were created and analyzed. The doses were prescribed either at the 0.5cm depth with 5.5 Gy for 4 fractions or at the cylinder surface with 8.8 Gy for 4 frac-tions, in various treatment lengths. A 0.5 cm shell volume called PTV_Eval was contoured for each plan and served as the target volume for dosimetric evaluation...
September 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27673946/the-development-of-an-umbrella-trial-plato-to-address-radiation-therapy-dose-questions-in-the-locoregional-management-of-squamous-cell-carcinoma-of-the-anus
#19
D Sebag-Montefiore, R Adams, S Bell, L Berkman, D C Gilbert, R Glynne-Jones, V Goh, W Gregory, M Harrison, L A Kachnic, M T Lee, L McParland, R Muirhead, B D O'Neill, G G Hutchins, S Rao, A Renehan, A Smith, G Velikova, M A Hawkins
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27658463/occupation-and-mesothelioma-in-sweden-updated-incidence-for-men-and-women-up-to-27-years-after-asbestos-ban
#20
Nils Plato, Jan Ivar Martinsen, Pär Sparén, Gunnar Hillerdal, Elisabete Weiderpass
Objectives: We updated the Swedish component of the Nordic Occupational Cancer (NOCCA) Study through 2009 in order to investigate the incidence of mesothelioma of the peritoneum and pleura in both sexes, and explored occupational exposures that may be associated with mesothelioma. Methods: The Swedish component of the NOCCA Study includes 6.78 million individuals. Data from this cohort was linked to the population-based Swedish Cancer Registry and Swedish Total Population Registry for three periods between 1961 and 2009 and then further linked to the Swedish NOCCA Job Exposure Matrix, which includes 25 carcinogenic substances and corresponding exposure levels for 280 occupations...
September 20, 2016: Epidemiology and Health
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