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https://www.readbyqxmd.com/read/29452843/ticagrelor-versus-clopidogrel-in-east-asian-patients-with-acute-coronary-syndrome-systematic-review-and-meta-analysis
#1
Naoki Misumida, Shunsuke Aoi, Sun Moon Kim, Khaled M Ziada, Ahmed Abdel-Latif
BACKGROUND: Bleeding complications are associated with unfavorable outcomes in patients with acute coronary syndrome (ACS). Compared to Whites, several studies demonstrated a higher risk of bleeding in Asians who present with acute myocardial infarction. To date, the efficacy and safety of ticagrelor in East Asian population have not been well established. METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials that compared ticagrelor and clopidogrel in East Asian patients with acute coronary syndrome (ACS)...
January 31, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29443375/ischaemic-events-and-stent-thrombosis-following-planned-discontinuation-of-study-treatment-with-ticagrelor-or-clopidogrel-in-the-plato-study
#2
Robert F Storey, Diego Ardissino, Luigi Vignali, Richard Cairns, Richard C Becker, Christopher P Cannon, Kenneth W Mahaffey, Anders Himmelmann, Hugo A Katus, Stefan K James, Lars Wallentin
No abstract text is available yet for this article.
February 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29390064/fibrin-clot-properties-independently-predict-adverse-clinical-outcome-following-acute-coronary-syndrome-a-plato-substudy
#3
Wael Sumaya, Lars Wallentin, Stefan K James, Agneta Siegbahn, Katja Gabrysch, Maria Bertilsson, Anders Himmelmann, Ramzi A Ajjan, Robert F Storey
Aims: To determine whether fibrin clot properties are associated with clinical outcomes following acute coronary syndrome (ACS). Methods and results: Plasma samples were collected at hospital discharge from 4354 ACS patients randomized to clopidogrel or ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial. A validated turbidimetric assay was employed to study plasma clot lysis time and maximum turbidity (a measure of clot density). One-year rates of cardiovascular (CV) death, spontaneous myocardial infarction (MI) and PLATO-defined major bleeding events were assessed after sample collection...
January 29, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29384027/an-evaluation-of-the-cost-effectiveness-of-comprehensive-mtm-integrated-with-point-of-care-phenotypic-and-genetic-testing-for-u-s-elderly-patients-after-percutaneous-coronary-intervention
#4
Arinze Nkemdirim Okere, Kyrian Ezendu, Abdrahmane Berthe, Vakaramoko Diaby
BACKGROUND: Poor health outcomes after percutaneous coronary intervention (PCI) in elderly patients is an area of concern among policymakers and administrators. In an effort to determine the best strategy to improve outcomes among elderly patients who underwent PCI, several studies have evaluated the cost-effectiveness of genotype-guided antiplatelet therapy compared with universal use of any one of the antiplatelet drugs indicated for patients with acute coronary syndrome (ACS) who underwent PCI...
February 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29344910/mimesis-and-clinical-pictures-thinking-with-plato-and-broekman-through-the-production-and-meaning-of-images-of-disease
#5
Marjolein Oele
This paper contends, following Plato and Broekman, that (1) seeing images as images is crucial to theorizing medicine and that (2) considering clinical pictures as images of images is a much-needed epistemic complement to the domineering view that sees clinical pictures as mirrors of disease. This does not only offer epistemic, but also ethical benefits to individual patients, especially in those cases where patients suffer from chronic, debilitating, and terminal illnesses and where medicine provides no, or limited, answers in terms of treatment, intervention, and meaning...
January 17, 2018: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29330256/osteoprotegerin-is-associated-with-major-bleeding-but-not-with-cardiovascular-outcomes-in-patients-with-acute-coronary-syndromes-insights-from-the-plato-platelet-inhibition-and-patient-outcomes-trial
#6
Thor Ueland, Axel Åkerblom, Tatevik Ghukasyan, Annika E Michelsen, Pål Aukrust, Richard C Becker, Maria Bertilsson, Anders Himmelmann, Stefan K James, Agneta Siegbahn, Robert F Storey, Frederic Kontny, Lars Wallentin
BACKGROUND: Elevated levels of osteoprotegerin, a secreted tumor necrosis factor-related molecule, might be associated with adverse outcomes in patients with coronary artery disease. We measured plasma osteoprotegerin concentrations on hospital admission, at discharge, and at 1 and 6 months after discharge in a predefined subset (n=5135) of patients with acute coronary syndromes in the PLATO (Platelet Inhibition and Patient Outcomes) trial. METHODS AND RESULTS: The associations between osteoprotegerin and the composite end point of cardiovascular death, nonprocedural spontaneous myocardial infarction or stroke, and non-coronary artery bypass grafting major bleeding during 1 year of follow-up were assessed by Cox proportional hazards models...
January 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29302901/a-history-and-overview-of-the-behavioral-neuroscience-of-learning-and-memory
#7
Robert E Clark
Here, I provide a basic history of important milestones in the development of theories for how the brain accomplishes the phenomenon of learning and memory. Included are the ideas of Plato, René Descartes, Théodule Ribot, William James, Ivan Pavlov, John Watson, Karl Lashley, and others. The modern era of learning and memory research begins with the description of H.M. by Brenda Milner and the gradual discovery that the brain contains multiple learning and memory systems that are supported by anatomically discrete brain structures...
January 5, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29299702/robot-life-simulation-and-participation-in-the-study-of-evolution-and-social-behavior
#8
Christopher M Kelty
This paper explores the case of using robots to simulate evolution, in particular the case of Hamilton's Law. The uses of robots raises several questions that this paper seeks to address. The first concerns the role of the robots in biological research: do they simulate something (life, evolution, sociality) or do they participate in something? The second question concerns the physicality of the robots: what difference does embodiment make to the role of the robot in these experiments. Thirdly, how do life, embodiment and social behavior relate in contemporary biology and why is it possible for robots to illuminate this relation? These questions are provoked by a strange similarity that has not been noted before: between the problem of simulation in philosophy of science, and Deleuze's reading of Plato on the relationship of ideas, copies and simulacra...
January 3, 2018: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/29275804/from-circe-s-root-to-spongia-soporifera-the-role-of-the-mandrake-as-true-anesthetic-of-ancient-times
#9
Marta Mion
Several ancient authors cited mandrake as a powerful and well-known narcotic drug: from Homer to Dioscorides, from Plato to Aristotle, passing from Hippocrates, Demosthenes, Theophrastus, Celsus, and Apuleius. Their detailed studies included the concrete appearance of the plant, the related recipes including mandrake as essential ingredient, the right dosages, how to administer the obtained medication, and the possible collateral effects. Even in the Middle Ages, the success of this root continued: Isidore of Seville, Theodoric of Cervia, Gilbertus Anglicus, and William from Varignana extensively reported their researches on sponges soaked with mandrake juice, which were used before surgical interventions as soporific tools...
October 2017: Journal of Anesthesia History
https://www.readbyqxmd.com/read/29249867/reflection-a-socratic-approach
#10
Inge C M Van Seggelen-Damen, René Van Hezewijk, Anne S Helsdingen, Iwan G J H Wopereis
Reflection is a fuzzy concept. In this article we reveal the paradoxes involved in studying the nature of reflection. Whereas some scholars emphasize its discursive nature, we go further and underline its resemblance to the self-biased dialogue Socrates had with the slave in Plato's Meno. The individual and internal nature of the reflection process creates difficulty for studying it validly and reliably. We focus on methodological issues and use Hans Linschoten's view of coupled systems to identify, analyze, and interpret empirical research on reflection...
December 2017: Theory & Psychology
https://www.readbyqxmd.com/read/29241289/-radiology-in-the-light-of-evolutionary-cognitive-theory
#11
Paul Gelinsky
An X-ray photograph is not adapted to the human a priori intuition: it is not colored, it is two-dimensional, has no depth and no perspective. A radiograph is composed by about 100 gradations of grey, of which the human eye cannot resolve more than 30. Projection radiography has a cardinal problem: the superposition of normal and pathological structures. Apart from visual physiology, visual psychology plays an essential role in diagnosis: expectation and stereotyped thinking influence the interpretation of visual perception...
December 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29209328/antibodies-against-myc-associated-zinc-finger-protein-an-independent-marker-in-acute-coronary-syndrome
#12
Diana Ernst, Christian Widera, Niklas T Baerlecken, Wolfgang Schlumberger, Cornelia Daehnrich, Reinhold E Schmidt, Katja Gabrysch, Lars Wallentin, Torsten Witte
Introduction: Atherosclerosis is considered the pathophysiology underlying cardiovascular (CVD), cerebrovascular, and peripheral vascular diseases. Evidence supporting an autoimmune component is emerging, with imaging studies correlating MYC-associated zinc finger protein antibody (MAZ-Ab) optical density (OD) with plaque activity. This study compares MAZ-Ab OD on ELISA testing among patients presenting with acute coronary syndromes (ACSs) to healthy controls and investigates the association of MAZ-Ab to traditional CVD risk factors...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29204676/surgical-management-in-acute-diverticulitis-and-its-association-with-multi-detector-ct-modified-hinchey-classification-and-clinical-parameters
#13
David D B Bates, Marina Bernal Fernandez, Cecilia Ponchiardi, Michael von Plato, Joshua P Teich, Chaitan Narsule, Stephan W Anderson, Avneesh Gupta, Christina A LeBedis
PURPOSE: To assess whether CT findings, clinical parameters, and modified Hinchey classification are predictive of management outcomes of patients with acute diverticulitis. MATERIALS AND METHODS: Data were accrued between January 2014 and December 2015. A total of 301 adult subjects were identified from radiology reports, of which six who did not met the inclusion criteria were excluded, thus yielding 295 subjects. Subjects were 43.1% (n = 127) male and 56.9% female (n = 168), with mean age 51...
December 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29170292/core-outcome-research-measures-in-anal-cancer-cormac-protocol-for-systematic-review-qualitative-interviews-and-delphi-survey-to-develop-a-core-outcome-set-in-anal-cancer
#14
Rebecca Fish, Caroline Sanders, Paula R Williamson, Andrew G Renehan
INTRODUCTION: The incidence of anal squamous cell carcinoma (ASCC) has increased threefold in the last 30 years. Initial treatment is chemoradiotherapy, associated with short-term and long-term side effects. Future therapy innovations aim to reduce morbidity in treatment of early tumours while maintaining treatment efficacy, and to escalate treatment intensity in locally advanced tumours with acceptable quality of life (QoL). However, all phase III randomised controlled trials to-date have utilised different primary outcomes, which hinders evidence synthesis and presents challenges to the selection of optimal outcomes in future trials...
November 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29079728/plato-software-provides-analytic-framework-for-investigating-complexity-beyond-genome-wide-association-studies
#15
Molly A Hall, John Wallace, Anastasia Lucas, Dokyoon Kim, Anna O Basile, Shefali S Verma, Cathy A McCarty, Murray H Brilliant, Peggy L Peissig, Terrie E Kitchner, Anurag Verma, Sarah A Pendergrass, Scott M Dudek, Jason H Moore, Marylyn D Ritchie
Genome-wide, imputed, sequence, and structural data are now available for exceedingly large sample sizes. The needs for data management, handling population structure and related samples, and performing associations have largely been met. However, the infrastructure to support analyses involving complexity beyond genome-wide association studies is not standardized or centralized. We provide the PLatform for the Analysis, Translation, and Organization of large-scale data (PLATO), a software tool equipped to handle multi-omic data for hundreds of thousands of samples to explore complexity using genetic interactions, environment-wide association studies and gene-environment interactions, phenome-wide association studies, as well as copy number and rare variant analyses...
October 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28953824/charity-hospitality-and-the-human-person
#16
Mark Agius, Anna McKeever
We believe that in order to properly interpret all aspects of human scientific enquiry in terms of its impact on human beings it is necessary to have an adequate all encompassing model of the human person. We began this presentation by discussing the differences between the 'Cartesian' Dualistic model of the human Person and that of Aquinas and Augustine (which depend on Aristotle and Plato respectively). While the 'Cartesian' describes a completely separate 'soul' or 'mind' from the physical body, the Thomistic model of the Human Person is that of an Embodied Spirit, in which every aspect of the human spirit is reflected in an aspect or function of the physical body...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28919132/the-east-the-west-and-the-universal-machine
#17
REVIEW
Bruno Marchal
After reviewing the basic of theology of Universal Numbers/Machines, as detailed in (Marchal, 2007), I illustrate how that body of thought might be used to shed some light upon the apparent dichotomy in Eastern/Western spirituality. This paper relies entirely on my previous inter-disciplinary work in mathematical logic, computer science and machine's theology, where "theology" is used here in the sense of Plato: it is the truth, or the "truth-theory" (in the sense of logicians) about a machine that the machine can either deduce from some of its primitive beliefs, or can be intuited in some sense that eventually is made clear through the modal logic of machine self-reference...
September 14, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28837213/antithrombotic-potency-of-ticagrelor-versus-clopidogrel-in-type-2-diabetic-patients-with-cardiovascular-disease
#18
M Urooj Zafar, Usman Baber, Donald A Smith, Samantha Sartori, Johanna Contreras, Juan Rey-Mendoza, Carlos A Linares-Koloffon, Gines Escolar, Roxana Mehran, Valentin Fuster, Juan J Badimon
Type-2 Diabetes Mellitus [T2DM] is associated with increased platelet reactivity and hypo-response to antiplatelet drugs. Ticagrelor, with its faster and more potent antiplatelet effects, was shown to reduce adverse events more than clopidogrel in the overall CAD patient population of PLATO trial, but the benefits did not reach statistical significance in the T2DM subgroup. To better understand these findings, we compared the antithrombotic effects of ticagrelor versus with clopidogrel in T2DM patients with cardiovascular disease...
October 5, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28761675/time-based-measures-of-treatment-effect-reassessment-of-ticagrelor-and-clopidogrel-from-the-plato-trial
#19
Andrea Bellavia, Lars Wallentin, Nicola Orsini, Stefan K James, Christopher P Cannon, Anders Himmelmann, Johan Sundström, Henrik Renlund, Per Lytsy
OBJECTIVE: Treatment effects to binary endpoints using time-to-event data in randomised controlled trials are typically summarised by reporting HRs derived with Cox proportional hazard models. Alternative and complementary methods include summarising the between-treatment differences on the metric time scale, quantifying the effect as delay of the event (DoE). The aim of this study was to reassess data from the PLATO study expressing the effects as the time by which the main outcomes are delayed or hastened due to treatment...
2017: Open Heart
https://www.readbyqxmd.com/read/28725514/gamma-knife-stereotactic-radiosurgery-for-grade-2-meningiomas
#20
Tamer Refaat, Michelle Gentile, Sean Sachdev, Prarthana Dalal, Anish Butala, Stanley Gutiontov, Irene Helenowksi, Plato Lee, Vythialinga Sathiaseelan, Orin Bloch, James Chandler, John A Kalapurakal
Purpose  This study aims to report long-term clinical outcomes after Gamma Knife radiosurgery (GKRS) for intracranial grade 2 meningiomas. Methods  In this Institutional Review Board approved study, we reviewed records of all patients with grade 2 meningiomas treated with GKRS between 1998 and 2014. Results  A total of 97 postoperative histopathologically confirmed grade 2 meningiomas in 75 patients were treated and are included in this study. After a mean follow-up of 41 months, 28 meningiomas had local recurrence (29...
August 2017: Journal of Neurological Surgery. Part B, Skull Base
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