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premenstrual dysphoric disorder

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https://www.readbyqxmd.com/read/28319848/treatment-of-premenstrual-dysphoric-disorder-with-the-gabaa-receptor-modulating-steroid-antagonist-sepranolone-uc1010-a-randomized-controlled-trial
#1
Marie Bixo, Karin Ekberg, Inger Sundström Poromaa, Angelica Lindén Hirschberg, Aino Fianu Jonasson, Lotta Andréen, Erika Timby, Marianne Wulff, Agneta Ehrenborg, Torbjörn Bäckström
CONTEXT: Allopregnanolone is a metabolite from progesterone and a positive modulator of the GABAA receptor. This endogenous steroid may induce negative mood in sensitive women when present in serum levels comparable to the premenstrual phase. Its endogenous isomer, isoallopregnanolone, has been shown to antagonize allopregnanolone effects in experimental animal and human models. OBJECTIVE: The objective was to test whether inhibition of allopregnanolone by treatment with the GABAA modulating steroid antagonist (GAMSA) Sepranolone (UC1010) during the premenstrual phase could reduce symptoms of the premenstrual dysphoric disorder (PMDD)...
March 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28257559/non-contraceptive-oestrogen-containing-preparations-for-controlling-symptoms-of-premenstrual-syndrome
#2
REVIEW
Bushra Naheed, Jan Herman Kuiper, Olalekan A Uthman, Fidelma O'Mahony, Patrick Michael Shaughn O'Brien
BACKGROUND: Premenstrual syndrome (PMS) is a psychological and somatic disorder of unknown aetiology, with symptoms typically including irritability, depression, mood swings, bloating, breast tenderness and sleep disturbances. About 3% to 10% of women who experience these symptoms may also meet criteria for premenstrual dysphoric disorder (PMDD). PMS symptoms recur during the luteal phase of the menstrual cycle and reduce by the end of menstruation. PMS results from ovulation and may be due to ovarian steroid interactions relating to neurotransmitter dysfunction...
March 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28237870/the-treatment-of-premenstrual-syndrome-with%C3%A2-preparations-of-vitex-agnus-castus-a%C3%A2-systematic-review-and-meta-analysis
#3
REVIEW
Saskia Verkaik, Astrid M Kamperman, Roos van Westrhenen, Peter F J Schulte
OBJECTIVE: Our objective was to determine the efficacy, tolerability, and acceptability of Vitex agnus castus preparations for treatment of premenstrual syndrome. STUDY DESIGN: All journals in the OVID software from inception through January 2016 were searched, including the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and PsycINFO. Gray literature was searched by Google Scholar and manufacturers of Vitex agnus castus preparations were contacted for information about unpublished trials...
February 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28193300/predictors-of-premenstrual-impairment-among-women-undergoing-prospective-assessment-for-premenstrual-dysphoric-disorder-a-cycle-level-analysis
#4
K M Schmalenberger, T A Eisenlohr-Moul, P Surana, D R Rubinow, S S Girdler
BACKGROUND: Women who experience significant premenstrual symptoms differ in the extent to which these symptoms cause cyclical impairment. This study clarifies the type and number of symptoms that best predict premenstrual impairment in a sample of women undergoing prospective assessment for premenstrual dysphoric disorder (PMDD) in a research setting. Central research goals were to determine (1) which emotional, psychological, and physical symptoms of PMDD are uniquely associated with premenstrual impairment, and (2) how many cyclical symptoms optimally predict the presence of a clinically significant premenstrual elevation of impairment...
February 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28066013/premenstrual-dysphoric-disorder-general-overview-treatment-strategies-and-focus-on-sertraline-for-symptom-onset-dosing
#5
Chittaranjan Andrade
No abstract text is available yet for this article.
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28044059/the-esc-e-z-complex-an-effector-of-response-to-ovarian-steroids-manifests-an-intrinsic-difference-in-cells-from-women-with-premenstrual-dysphoric-disorder
#6
N Dubey, J F Hoffman, K Schuebel, Q Yuan, P E Martinez, L K Nieman, D R Rubinow, P J Schmidt, D Goldman
Clinical evidence suggests that mood and behavioral symptoms in premenstrual dysphoric disorder (PMDD), a common, recently recognized, psychiatric condition among women, reflect abnormal responsivity to ovarian steroids. This differential sensitivity could be due to an unrecognized aspect of hormonal signaling or a difference in cellular response. In this study, lymphoblastoid cell line cultures (LCLs) from women with PMDD and asymptomatic controls were compared via whole-transcriptome sequencing (RNA-seq) during untreated (ovarian steroid-free) conditions and following hormone treatment...
January 3, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28041003/making-strides-to-simplify-diagnosis-of-premenstrual-dysphoric-disorder
#7
C Neill Epperson, Liisa V Hantsoo
No abstract text is available yet for this article.
January 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27901212/validation-of-the-brazilian-portuguese-version-of-the-premenstrual-symptoms-screening-tool-psst-and-association-of-psst-scores-with-health-related-quality-of-life
#8
Rachel de A Câmara, Cristiano A Köhler, Benicio N Frey, Thomas N Hyphantis, André F Carvalho
Objective: To develop and validate a Brazilian Portuguese version of the Premenstrual Symptoms Screening Tool (PSST), a questionnaire used for the screening of premenstrual syndrome (PMS) and of the most severe form of PMS, premenstrual dysphoric disorder (PMDD). The PSST also rates the impact of premenstrual symptoms on daily activities. Methods: A consecutive sample of 801 women aged ≥ 18 years completed the study protocol. The internal consistency, test-retest reliability, and content validity of the Brazilian PSST were determined...
November 24, 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27798029/stress-fracture-and-premenstrual-syndrome-in-japanese-adolescent-athletes-a-cross-sectional-study
#9
Takashi Takeda, Yoko Imoto, Hiroyo Nagasawa, Atsuko Takeshita, Masami Shiina
OBJECTIVES: To investigate the relationship between the occurrence of stress fracture and premenstrual syndrome (PMS)/premenstrual dysphoric disorder (PMDD) in Japanese adolescent athletes. DESIGN: Cross-sectional study. SETTING: Osaka, Japan. PARTICIPANTS: A school-based survey on menstruation and school life was conducted using a sample of 1818 Japanese female students who belonged to two public high schools in Japan...
October 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27635178/toxoplasma-gondii-infection-and-premenstrual-dysphoric-disorder-a-cross-sectional-study
#10
Cosme Alvarado-Esquivel, Luis Francisco Sanchez-Anguiano, Jesus Hernandez-Tinoco, Alma Rosa Perez-Alamos, Yazmin Del Rosario Rico-Almochantaf, Sergio Estrada-Martinez, Raquel Vaquera-Enriquez, Arturo Diaz-Herrera, Agar Ramos-Nevarez, Ada Agustina Sandoval-Carrillo, Jose Manuel Salas-Pacheco, Sandra Margarita Cerrillo-Soto, Elizabeth Irasema Antuna-Salcido, Oliver Liesenfeld, Carlos Alberto Guido-Arreola
BACKGROUND: Premenstrual dysphoric disorder is a severe form of premenstrual syndrome. The influence of Toxoplasma gondii (T. gondii) infection on clinical features in women with this disorder has not been studied. Therefore, we determined the association of T. gondii infection with symptoms and signs in women suffering from premenstrual dysphoric disorder. METHODS: We performed a cross-sectional study of 151 women suffering from premenstrual dysphoric disorder...
October 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27607359/affective-temperaments-and-emotional-traits-are-associated-with-a-positive-screening-for-premenstrual-dysphoric-disorder
#11
Rachel A Câmara, Cristiano A Köhler, Michael Maes, Paulo R Nunes-Neto, André R Brunoni, João Quevedo, Brisa S Fernandes, Giulio Perugi, Thomas N Hyphantis, André F Carvalho
OBJECTIVES: Preliminary evidence indicates that premenstrual dysphoric disorder (PMDD) may be frequently co-morbid with bipolar spectrum disorders. In addition, the manifestations of PMDD seem similar to a subthreshold depressive mixed state. Nevertheless, the associations between PMDD and affective temperaments and emotional traits have not been previously investigated. METHODS: A consecutive sample of 514 drug-free Brazilian women (mean age: 22.8; SD=5.4years) took part in this cross-sectional study...
August 18, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27538401/emotional-regulation-difficulties-and-premenstrual-symptoms-among-israeli-students
#12
Inbal Reuveni, Dan Rotem, Segman Ronen, Evron Ron, Laufer Sofia, Goelman Gadi, Bonne Omer, Canetti Laura
Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS) reported to affect 3-8 % of women of reproductive age and resulting in marked emotional and occupational impairment. Despite its prevalence, the etiology of PMDD is largely unknown, and patients remain mostly undiagnosed and poorly treated. It has been suggested that PMDD is a manifestation of underlying depressive disorder which is associated with the inability to regulate emotions in an adaptive manner. Therefore, we hypothesized that women with PMDD would exhibit increased difficulty with emotional regulation...
August 18, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27523500/toward-the-reliable-diagnosis-of-dsm-5-premenstrual-dysphoric-disorder-the-carolina-premenstrual-assessment-scoring-system-c-pass
#13
Tory A Eisenlohr-Moul, Susan S Girdler, Katja M Schmalenberger, Danyelle N Dawson, Pallavi Surana, Jacqueline L Johnson, David R Rubinow
OBJECTIVE: Despite evidence for the validity of premenstrual dysphoric disorder (PMDD) and the inclusion of the disorder in DSM-5, variable diagnostic practices compromise the construct validity of the diagnosis and threaten the clarity of efforts to understand and treat its underlying pathophysiology. In an effort to hasten and streamline the translation of the DSM-5 criteria for PMDD into terms compatible with existing research practices, the authors present the development and initial validation of the Carolina Premenstrual Assessment Scoring System (C-PASS)...
January 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27521647/development-of-a-screening-instrument-to-assess-premenstrual-dysphoric-disorder-as-conceptualized-in-dsm-5
#14
Leire Aperribai, Itziar Alonso-Arbiol, Nekane Balluerka, Laurence Claes
OBJECTIVE: This study aimed at developing and validating a screening instrument to assess premenstrual dysphoric disorder (PMDD) based on DSM-5 criteria, which is not yet available. METHODS: The Premenstrual Dysphoric Disorder Questionnaire for DSM-5 (Cuestionario del Trastorno Disfórico Premenstrual - DSM-5), a 25-item questionnaire to assess PMDD was developed and completed in Spanish by 2820 women (Age M=23.43; SD=7.87). Exploratory factor analysis (N=1410) and confirmatory factor analysis (N=1410) were performed in randomly selected subsamples...
September 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27479626/premenstrual-syndrome-and-premenstrual-dysphoric-disorder
#15
Sabrina Hofmeister, Seth Bodden
Premenstrual disorders affect up to 12% of women. The subspecialties of psychiatry and gynecology have developed overlapping but distinct diagnoses that qualify as a premenstrual disorder; these include premenstrual syndrome and premenstrual dysphoric disorder. These conditions encompass psychological and physical symptoms that cause significant impairment during the luteal phase of the menstrual cycle, but resolve shortly after menstruation. Patientdirected prospective recording of symptoms is helpful to establish the cyclical nature of symptoms that differentiate premenstrual syndrome and premenstrual dysphoric disorder from other psychiatric and physical disorders...
August 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27454391/premenstrual-dysphoric-disorder-without-comorbid-psychiatric-conditions-a-systematic-review-of-therapeutic-options
#16
REVIEW
Gianna Sepede, Fabiola Sarchione, Ilaria Matarazzo, Massimo Di Giannantonio, Rosa Maria Salerno
OBJECTIVES: Premenstrual dysphoric disorder (PMDD) is a disabling condition affecting approximately 2% to 8% of women during reproductive age. It has been recently included in the mood disorder section of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, but its treatment as a primary psychiatric illness is still debated, because of the high prevalence of other mental disturbances in PMDD patients. On the other hand, clear clinical guidelines for PMDD patients not suffering from comorbid mental conditions are not yet available...
September 2016: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27385849/prevalence-of-premenstrual-syndrome-and-premenstrual-dysphoric-disorder-among-college-students-of-bhavnagar-gujarat
#17
Chintan Madhusudan Raval, Bharat Navinchandra Panchal, Deepak Sachidanand Tiwari, Ashok Ukabhai Vala, Renish Bhupendrabhai Bhatt
BACKGROUND: Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS) characterized by mood changes, anxiety, and somatic symptoms experienced during the specific time of menstrual cycle. Prevalence data of PMS and PMDD is sparse among college girls in India. AIMS: The aim of this study is to study the prevalence of PMS and PMDD among college students of Bhavnagar (Gujarat), its associated demographic and menstrual factors, to rank common symptoms and compare premenstrual symptom screening tool (PSST) with Structured Clinical Interview for DSM-IV-TR defined PMDD (SCID-PMDD) for sensitivity and specificity...
April 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/27378657/precise-and-accurate-assay-of-pregnenolone-and-five-other-neurosteroids-in-monkey-brain-tissue-by-lc-ms-ms
#18
Alain Y Dury, Yuyong Ke, Fernand Labrie
A series of steroids present in the brain have been named "neurosteroids" following the possibility of their role in the central nervous system impairments such as anxiety disorders, depression, premenstrual dysphoric disorder (PMDD), addiction, or even neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Study of their potential role requires a sensitive and accurate assay of their concentration in the monkey brain, the closest model to the human. We have thus developed a robust, precise and accurate liquid chromatography-tandem mass spectrometry method for the assay of pregnenolone, pregnanolone, epipregnanolone, allopregnanolone, epiallopregnanolone, and androsterone in the cynomolgus monkey brain...
September 2016: Steroids
https://www.readbyqxmd.com/read/27355449/a-symptom-diary-to-assess-severe-premenstrual-syndrome-and-premenstrual-dysphoric-disorder
#19
Carolyn Janda, Johanna N Kues, Gerhard Andersson, Maria Kleinstäuber, Cornelia Weise
The differentiation between premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) has been widely discussed. PMDD is listed as a mental disorder in the DSM-5, whereas PMS is not considered as a mental disorder in any diagnostic manual. Consequently, PMS is operationalized in different ways. Keeping a symptom diary is required to diagnose PMDD but is also recommended for PMS. The aim of our study was, therefore, to operationalize PMS and PMDD within a DSM-5-based symptom diary. We developed a symptom-intensity-score (SI-score) and an interference-score (INT-score) to evaluate the symptom diary...
June 29, 2016: Women & Health
https://www.readbyqxmd.com/read/27347888/reproductive-steroid-regulation-of-mood-and-behavior
#20
Crystal Edler Schiller, Sarah L Johnson, Anna C Abate, Peter J Schmidt, David R Rubinow
In this article, we examine evidence supporting the role of reproductive steroids in the regulation of mood and behavior in women and the nature of that role. In the first half of the article, we review evidence for the following: (i) the reproductive system is designed to regulate behavior; (ii) from the subcellular to cellular to circuit to behavior, reproductive steroids are powerful neuroregulators; (iii) affective disorders are disorders of behavioral state; and (iv) reproductive steroids affect virtually every system implicated in the pathophysiology of depression...
June 13, 2016: Comprehensive Physiology
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