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Medium chain triglyceride

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https://www.readbyqxmd.com/read/28438574/extreme-hypertriglyceridemia-pseudohyponatremia-and-pseudoacidosis-in-a-neonate-with-lipoprotein-lipase-deficiency-due-to-segmental-uniparental-disomy
#1
Ambika P Ashraf, Anna C E Hurst, Abhimanyu Garg
Extreme hypertriglyceridemia is rare in the neonatal period. We report a neonate with lipoprotein lipase (LPL) deficiency who presented with diagnostic and management conundrum. A full-term 36-day-old female was noted to have "Pepto-Bismol like" blood when repeating a newborn screening. The initial plasma triglyceride level was 24,318 mg/dL. The laboratory tests revealed serum bicarbonate level of <5 mmol/L, sodium of 127 mmol/L, and severe anemia. There were no signs of acute distress. The point of care capillary blood testing, however, demonstrated normal serum pH (7...
April 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28429991/effects-of-medium-chain-triglycerides-on-intestinal-morphology-and-energy-metabolism-of-intrauterine-growth-retarded-weanling-piglets
#2
Li-Li Zhang, Hao Zhang, Yue Li, Tian Wang
It has been shown that there is a relationship between intrauterine growth retardation (IUGR) and postnatal intestinal damage involved in energy deficits. Therefore, the present study was conducted to investigate the effect of medium-chain triglycerides (MCT) on the intestinal morphology, intestinal function and energy metabolism of piglets with IUGR. At weaning (21 ± 1.1 d of age), 24 IUGR piglets and 24 normal birth weight (NBW) piglets were selected according to their birth weights (BW) (IUGR: 0.95 ± 0...
June 2017: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/28429080/effect-of-gpr84-deletion-on-obesity-and-diabetes-development-in-mice-fed-long-chain-or-medium-chain-fatty-acid-rich-diets
#3
Eugene Du Toit, Liam Browne, Helen Irving-Rodgers, Helen M Massa, Nicolette Fozzard, Michael P Jennings, Ian R Peak
PURPOSE: Although there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the pro-inflammatory, medium chain fatty acid receptor (GPR84) in the aetiology of obesity and glucose intolerance is not well characterised. We set out to determine whether GPR84 expression influences obesity and glucose intolerance susceptibility in MCFA and LCFA rich diet fed mice...
April 20, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28416069/-dietary-treatment-of-medically-refractory-epilepsy-in-children-and-adolescents
#4
Frederikke Høgsbro-Rode, Katrine M Harris Johannesen, Vibeke Stubbings, Helle Hjalgrim
Ketogenic diet (KD) is used worldwide in the treatment of medically refractory epilepsy. Since the introduction of KD in the early 1900s, new approaches such as medium-chain triglyceride ketogenic diet, modified Atkins diet and low glycaemic index treatment have been suggested as alternative treatments. Several studies have documented significant seizure reduction from all four diets. The aim of this article is to give an overview of the effect of dietary treatment and to discuss advantages in initiating dietary treatment as an early treatment instead of as a last option...
April 3, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28405814/effects-of-coconut-oil-consumption-on-energy-metabolism-cardiometabolic-risk-markers-and-appetitive-responses-in-women-with-excess-body-fat
#5
Flávia Xavier Valente, Flávia Galvão Cândido, Lílian Lelis Lopes, Desirrê Morais Dias, Samantha Dalbosco Lins Carvalho, Patrícia Feliciano Pereira, Josefina Bressan
PURPOSE: Virgin coconut oil (VCO) is a medium-chain fatty acid source with popularly attributed benefits on obesity management. However, its role on obesity requires elucidation due to its saturated nature. In the study herein, we investigated acute effects of VCO consumption on energy metabolism, cardiometabolic risk markers, and appetitive responses in women with excess body fat. METHODS: Fifteen adult women with excess body fat (37.43 ± 0.83%) participated in this randomized, crossover, controlled study...
April 12, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28392417/pharmacological-inhibition-of-carnitine-palmitoyltransferase-1-restores-mitochondrial-oxidative-phosphorylation-in-human-trifunctional-protein-deficient-fibroblasts
#6
Bruno Lefort, Elodie Gouache, Cécile Acquaviva, Marine Tardieu, Jean François Benoist, Jean-François Dumas, Stéphane Servais, Stéphan Chevalier, Christine Vianey-Saban, François Labartheh
BACKGROUND: Mitochondrial Trifunctional Protein deficiency (TFPD) is a severe genetic disease characterized by altered energy metabolism and accumulation of long-chain (LC) acylcarnitines in blood and tissues. This accumulation could impair the mitochondrial oxidative phosphorylation (OxPhos), contributing to the non-optimal outcome despite conventional diet therapy with medium-chain triglycerides (MCT). METHOD: Acylcarnitine and OxPhos parameters were measured in TFPD-fibroblasts obtained from 8 children and cultured in medium mimicking fasting (LCFA) or conventional treatment (MCT), with or without Etomoxir (ETX) an inhibitor of carnitine palmitoyltransferase 1 (CPT1) activity, and were compared to results obtained with fibroblasts from 5 healthy-control children...
April 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28376626/waldmann-s-disease-a-rare-cause-of-protein-losing-enteropathy-in-an-adult-patient
#7
Cláudio Rodrigues Martins, Alice Gagnaire, Florian Rostain, Come Lepage
Primary intestinal lymphangiectasia or Waldmann's disease is an uncommon cause of protein losing enteropathy with an unknown etiology and is usually diagnosed during childhood. It is characterized by dilation and leakage of intestinal lymph vessels leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia. Differential diagnosis should include erosive and non-erosive gastrointestinal disorders, conditions involving mesenteric lymphatic obstruction and cardiovascular disorders that increase central venous pressure...
April 5, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28363598/p-p-methoxyl-diphenyl-diselenide-loaded-polymeric-nanocapsules-are-chemically-stable-and-do-not-induce-toxicity-in-mice
#8
Marcel Henrique Marcondes Sari, Luana Mota Ferreira, Vanessa Angonesi Zborowski, Paulo Cesar Oliveira Araujo, Verônica Ferrari Cervi, César Augusto Brüning, Letícia Cruz, Cristina Wayne Nogueira
Organoselenium compounds have been targeted to new therapeutic tools development due to their pharmacological actions. However, some toxicity issues and physicochemical limitations delay the clinical application of these compounds. The incorporation of organoselenium molecules into nanostructured systems arises as a promising alternative to overcome such restrictions. The current study proposed the characterization of the polymeric nanocapsules of p,p'-methoxyl-diphenyl diselenide [(OMePhSe)2] as well as the evaluation of the in vivo toxicity and biodistribution profile...
March 28, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28361739/ghrelin-activation-and-neuropeptide-y-elevation-in-response-to-medium-chain-triglyceride-administration-in-anorexia-nervosa-patients
#9
Keisuke Kawai, Megumi Nakashima, Masayasu Kojima, Sakino Yamashita, Shu Takakura, Miki Shimizu, Chiharu Kubo, Nobuyuki Sudo
BACKGROUND & AIMS: Ghrelin, a peptide found in the stomach, increases appetite and fat-free mass while suppressing energy expenditure. Ghrelin requires modification by medium-chain triglycerides (MCTs) to exert its physiological effects. In this study, we investigated ghrelin activation and the resulting physiological changes following MCT administration. METHODS: Thirty participants were selected from among inpatients diagnosed with anorexia nervosa (AN). The patients were randomly divided into three groups by the MCT content of their nutritional supplement: (1) 'MCT high' (>6 g/day), (2) 'MCT moderate' (1-6 g/day), and (3) 'MCT low' (<1 g/day)...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28355118/carbonyl-compounds-produced-by-vaporizing-cannabis-oil-thinning-agents
#10
William D Troutt, Matthew D DiDonato
OBJECTIVE: Cannabis use has increased in the United States, particularly the use of vaporized cannabis oil, which is often mixed with thinning agents for use in vaporizing devices. E-cigarette research shows that heated thinning agents produce potentially harmful carbonyls; however, similar studies have not been conducted (1) with agents that are commonly used in the cannabis industry and (2) at temperatures that are appropriate for cannabis oil vaporization. The goal of this study was to determine whether thinning agents used in the cannabis industry produce potentially harmful carbonyls when heated to a temperature that is appropriate for cannabis oil vaporization...
March 29, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28352349/role-of-mesenchymal-stem-cells-on-differentiation-in-steroid-induced-avascular-necrosis-of-the-femoral-head
#11
Tiansheng Wang, Shoufa Teng, Yingxia Zhang, Fa Wang, Haijiao Ding, Li Guo
Steroids are known to inhibit osteogenic differentiation and decrease bone formation in mesenchymal stem cells (MSCs), while concomitantly inducing steroid-induced avascular necrosis of the femoral head (SANFH). The aim of the present study was to evaluate the function of MSCs on differentiation in SANFH and investigate the pathobiological mechanisms underlying SANFH in a rabbit model. MSCs in the control, trauma-induced ANFH (TANFH) and SANFH groups were incubated with low-glucose complete Dulbeccos modified Eagles medium containing 10% fetal bovine serum...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28352175/factors-influencing-transfection-efficiency-of-pidua-nanoemulsion-complexes-in-a-mucopolysaccharidosis-type-i-murine-model
#12
Michelle Fraga, Talita Giacomet de Carvalho, Juliana Bidone, Roselena Silvestri Schuh, Ursula Matte, Helder Ferreira Teixeira
Mucopolysaccharidosis type I (MPS I) is an autosomal disease caused by alpha-l-iduronidase (IDUA) deficiency. This study used IDUA knockout mice as a model to evaluate whether parameters such as dose of plasmid and time of treatment could influence the transfection efficiency of complexes formed with PEGylated cationic nanoemulsions and plasmid (pIDUA), which contains the gene that encodes for IDUA. Formulations were composed of medium chain triglycerides, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(amino[polyethylene glycol]-2000), 1,2-dioleoyl-sn-glycero-3-trimethylammonium propane (DOTAP), glycerol, and water and were prepared by the adsorption or encapsulation of preformed pIDUA-DOTAP complexes by high-pressure homogenization...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28344473/d-%C3%AE-tocopherol-nanoemulsions-size-properties-rheological-behavior-surface-tension-osmolarity-and-cytotoxicity
#13
M C Teixeira, P Severino, T Andreani, P Boonme, A Santini, A M Silva, E B Souto
The aim of this study was the assessment of the physicochemical stability of d-α-tocopherol formulated in medium chain triglyceride nanoemulsions, stabilized with Tween®80 and Lipoid®S75 as surfactant and co-surfactant, respectively. d-α-tocopherol was selected as active ingredient because of its well-recognized interesting anti-oxidant properties (such as radical scavenger) for food and pharmaceutical industries. A series of nanoemulsions of mean droplet size below 90 nm (polydispersity index < 0...
February 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28342580/evidence-based-management-of-chylothorax-in-infants
#14
Joseph T Church, Alexis G Antunez, Ashley Dean, Niki Matusko, Kristopher B Deatrick, Mohammad A Attar, Samir K Gadepalli
PURPOSE: Management guidelines for infants with chylothorax lack substantial evidence. We sought to identify variables that impact outcomes in these patients in order to develop an evidence-based management algorithm. METHODS: We retrospectively reviewed the medical records of all infants diagnosed with chylothorax from June 2005 to December 2014 at our institution. Data collected included demographics, chest tube output (CTO), medical and dietary interventions, surgical procedures, and absolute lymphocyte count (ALC)...
March 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28317729/chemical-components-and-emulsification-properties-of-mucilage-from-dioscorea-opposita-thunb
#15
Fanyi Ma, Yun Zhang, Yanna Yao, Yurong Wen, Weiping Hu, Jie Zhang, Xiuhua Liu, Alan E Bell, Carina Tikkanen-Kaukanen
The properties of mucilage obtained from Dioscorea opposita, generated during industrial manufacturing were investigated in this study. Characteristics such as monosaccharide content, amino acid content, molecular weight, and structural features were measured, whereas morphology was observed using a scanning/transmission electron microscope. Additionally, emulsification properties at different concentrations (0.2%, 0.4%, 0.6%, 0.8%, and 1.0%) and under acidic and basic pH (5.0 and 9.0) conditions were studied...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28296748/efficacy-of-lidocaine-on-preventing-incidence-and-severity-of-pain-associated-with-propofol-using-in-pediatric-patients-a-prisma-compliant-meta-analysis-of-randomized-controlled-trials
#16
Bing-Chen Lang, Chun-Song Yang, Ling-Li Zhang, Wen-Sheng Zhang, Yu-Zhi Fu
BACKGROUND: Propofol injection pain was considered as one conundrum during clinical anesthesia. The systematic review about the effect of lidocaine in reducing injection pain among children has not been established. The aim of the study was to systematically evaluate the efficacy and safety of such intervention. METHODS: The literature search was performed from the inception to the May 31, 2016 in PubMed, Ovid EMBASE, and Cochrane database. All randomized controlled trials that using lidocaine for propofol injection pain in children were enrolled...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28281508/-protein-losing-enteropathy
#17
A I Parfenov, L M Krums
Protein-losing enteropathy (PLE) is a rare complication of intestinal diseases. Its main manifestation is hypoproteinemic edema. The diagnosis of PLE is based on the verification of protein loss into the intestinal lumen, by determining fecal α1-antitrypsin concentration and clearance. The localization of the affected colonic segment is clarified using radiologic and endoscopic techniques. The mainstay of treatment for PLE is a fat-free diet enriched with medium-chain triglycerides. Surgical resection of the affected segment of the colon may be the treatment of choice for severe hypoproteinemia resistant to drug therapy...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28267668/transport-of-lipid-nano-droplets-through-mdck-epithelial-cell-monolayer
#18
Pulkit Khatri, Jun Shao
This study aims to investigate the transport of lipid nano-droplets through MDCK epithelial cell monolayer. Nanoemulsions of self-nano-emulsifying drug delivery systems (SNEDDS) labeled with radioactive C18 triglyceride were developed. The effect of droplet size and lipid composition on the transport was investigated. The results showed that the lipid nano-droplet transport through MDCK cell monolayer was as high as 2.5%. The transport of lipid nano-droplets was higher for nanoemulsions of medium chain glycerides than the long chain glycerides...
May 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28262846/antiseizure-effects-of-ketogenic-diet-on-seizures-induced-with-pentylenetetrazole-4-aminopyridine-and-strychnine-in-wistar-rats
#19
E O Sanya, A O Soladoye, O O Desalu, P M Kolo, L A Olatunji, J K Olarinoye
The ketogenic diet (KD) is a cheap and effective alternative therapy for most epilepsy. There are paucity of experimental data in Nigeria on the usefulness of KD in epilepsy models. This is likely to be responsible for the poor clinical acceptability of the diet in the country. This study therefore aimed at providing experimental data on usefulness of KD on seizure models.  The study used 64 Wistar rats that were divided into two dietary groups [normal diet (ND) and ketogenic diet (KD)]. Animal in each group were fed for 35days...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28254296/enhanced-photostability-radical-scavenging-and-antitumor-activity-of-indole-3-carbinol-loaded-rose-hip-oil-nanocapsules
#20
Mailine Gehrcke, Laura Minussi Giuliani, Luana Mota Ferreira, Allanna Valentini Barbieri, Marcel Henrique Marcondes Sari, Elita Ferreira da Silveira, Juliana Hofstatter Azambuja, Cristina Wayne Nogueira, Elizandra Braganhol, Letícia Cruz
This study aimed to develop poly(ε-caprolactone) nanocapsules loaded with indole-3-cabinol (I3C) using rose hip oil (RHO) or medium chain triglycerides (MCT) as oil core. In vitro radical scavenging activity (DPPH method), hemolysis, and antitumor effects on breast (MCF-7) and glioma (C6) cells were conducted. Preformulation evaluations revealed that RHO is suitable to prepare the nanocapsules considering the log P determination and dissolution/swelling experiments of polymer films. The nanocapsules were prepared and presented adequate physicochemical characteristics as mean size around 250nm, polydispersity index values <0...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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