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https://www.readbyqxmd.com/read/29244897/new-electrode-and-electrolyte-configurations-for-lithium-oxygen-battery
#1
Ulderico Ulissi, Giuseppe Antonio Elia, Sangsik Jeong, Jakub Reiter, Nikolaos Tsiouvaras, Stefano Passerini, Jusef Hassoun
We report herein cathode configurations alternative to the most diffused ones for application in lithium-oxygen batteries using an ionic liquid-based electrolyte. The electrodes employ high surface area conductive carbon as the reaction host and polytetrafluoroethylene as the binding agent to enhance ORR/OER reversibility. Roll-pressed, self-standing electrodes (SSEs) and thinner, spray deposited electrodes (SDEs) are characterized in lithium-oxygen cells using an ionic liquid (IL) based electrolyte formed by mixing lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) salt in N,N-diethyl-N-(2-methoxyethyl)-N-methylammonium bis(trifluoromethanesulfonyl)imide (DEMETFSI)...
December 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29242398/actual-impact-of-68ga-psma-11-pet-ct-on-the-management-of-prostate-cancer-patients-with-biochemical-recurrence
#2
Jérémie Calais, Wolfgang P Fendler, Matthias Eiber, Jeannine Gartmann, Fang-I Chu, Nicholas G Nickols, Robert R Reiter, Matthew B Rettig, Leonard S Marks, Thomas E Ahlering, Lynda Huynh, Roger Slavik, Pawan Gupta, Andrew Quon, Martin S Allen-Auerbach, Johannes Czernin, Ken Herrmann
Purpose: In this prospective survey of referring physicians, we investigated whether and how Gallium-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (PSMA-11 PET/CT) affects the actually implemented management of prostate cancer patients wih biochemical recurrence (BCR). Methods: We conducted a prospective survey of physicians (NCT02940262) who referred 161 patients with prostate cancer BCR (median Prostate Specific Antigen (PSA) value 1.7 ng/ml (range 0.05-202)). Referring physicians completed one questionnaire prior to the scan to indicate the treatment plan without PSMA-11 PET/CT information (Q1; n = 101); one immediately after the scan to denote intended management changes (Q2; n = 101); and one 3 to 6 months later to document the final implemented management (Q3; n = 56)...
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29242300/blood-cytokine-concentrations-of-pediatric-anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-patients
#3
Fabian Knörr, Christine Damm-Welk, Stephanie Ruf, Vijay Kumar Singh, Martin Zimmermann, Alfred Reiter, Wilhelm Woessmann
Patients with anaplastic lymphoma kinase -positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, an unspecific immune stimulation by the tumor or differences in the strength of the patient's anti-lymphoma immunity. We systematically correlated pre-treatment concentrations of 25 cytokines with clinical and biological characteristics in a well characterized cohort of 119 uniformly treated pediatric anaplastic large cell lymphoma patients...
December 14, 2017: Haematologica
https://www.readbyqxmd.com/read/29240780/filamina-and-formin2-regulate-skeletal-muscular-and-intestinal-formation-through-mesenchymal-progenitor-proliferation
#4
Gewei Lian, Sneha Kanaujia, Timothy Wong, Volney Sheen
The effects of actin dependent molecular mechanisms in coordinating cellular proliferation, migration and differentiation during embryogenesis are not well-understood. We have previously shown that actin-binding Filamin A (FlnA) and actin-nucleating Formin 2 (Fmn2) influence the development of the brain causing microcephaly in mice. In this study, we broaden this phenotype to explore the effects of these two proteins in the development of extra-CNS organ systems, including the gut, muscle, and skeleton. We observed defects in rib and sternum midline closure leading to thoracoabdominal schisis in FlnA+Fmn2 knockout mice, reminiscent of the pentalogy of Cantrell syndrome...
2017: PloS One
https://www.readbyqxmd.com/read/29237681/plasma-proteomics-for-epidemiology-increasing-throughput-with-standard-flow-rates
#5
Xiaoke Yin, Ferheen Baig, Eloi Haudebourg, Richard T Blankley, Tejas Gandhi, Sebastian Müller, Lukas Reiter, Helmut Hinterwirth, Raimund Pechlaner, Sotirios Tsimikas, Peter Santer, Johann Willeit, Stefan Kiechl, Joseph L Witztum, Anthony Sullivan, Manuel Mayr
BACKGROUND: Mass spectrometry is selective and sensitive, permitting routine quantification of multiple plasma proteins. However, commonly used nanoflow liquid chromatography (LC) approaches hamper sample throughput, reproducibility, and robustness. For this reason, most publications using plasma proteomics to date are small in study size. METHODS AND RESULTS: Here, we tested a standard-flow LC mass spectrometry (MS) method using multiple reaction monitoring for the application to large epidemiological cohorts...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29232503/calculation-of-magnetic-shielding-constants-with-meta-gga-functionals-employing-the-multipole-accelerated-resolution-of-the-identity-implementation-and-assessment-of-accuracy-and-efficiency
#6
Kevin Reiter, Fabian Mack, Florian Weigend
We present a highly efficient implementation for density functional calculations of chemical shielding constants. It employs the multipole-accelerated resolution of the identity for the calculation of the Coulomb part, which complements the usage of low order scaling routines for the evaluation of the exchange-correlation part and the Hartree-Fock exchange part. Introduced errors for shifts of chemical shielding constants of H, C, F and P are evaluated for respective test sets of molecules and are related to the accuracy of shifts obtained with hybrid and non-hybrid functionals of the generalized gradient approximation type as well as for meta-GGA functionals themselves, also considering solvation effects...
December 12, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29232352/case-report-of-a-5-year-old-with-epiglottitis-an-atypical-presentation-of-an-uncommon-disease
#7
Amanda J Kasem
Epiglottitis is a rarely encountered infection in pediatrics since the advent of the conjugate Haemophilus influenzae type b vaccine first introduced in the United States in 1985. However, the disease remains a much feared infection in pediatrics. The literature reiterates the importance of early recognition, avoidance of agitating the patient, and the need for securing the airway in the operating room as key and essential features to a good outcome. However, with only 1 case per 200,000 children reported in the United States in 2006, most practitioners have never encountered this infection...
December 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29229408/imbalance-in-dna-repair-machinery-is-associated-with-brafv600e-mutation-and-tumor-aggressiveness-in-papillary-thyroid-carcinoma
#8
Bruna S Lutz, Natalia M Leguisamo, Nicole K Cabral, Helena C Gloria, Keli C Reiter, Grasiela Agnes, Virgilio Zanella, Erika L S Meyer, Jenifer Saffi
The involvement of alterations in MLH1, an essential mismatch repair component, in BRAFV600E mutated papillary thyroid carcinoma (PTC) has been suggested to be associated with features of tumor aggressiveness. Thirty-two PTC and surrounding normal thyroid tissues were evaluated for 11 representative DNA repair genes expression. BRAFV600E mutational status assessment and clinicopathological correlations were evaluated for their gene and protein expression. BRAFV600E PTC is associated with lower levels of XPD and MLH1 gene expression...
December 8, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29221522/barriers-to-smoking-cessation-among-drug-resistant-tuberculosis-patients-in-south-africa
#9
Zifikile Phindile Shangase, Joyce Mahlako Tsoka-Gwegweni, Catherine O Egbe
BACKGROUND: Drug-resistant tuberculosis (DR-TB) remains a significant cause of morbidity and mortality. The long-term health effects of smoking and the risk of adverse TB outcomes, including increased periods of infectiousness, have been reported among DR-TB patients in South Africa. OBJECTIVES: This study aimed to identify the barriers to smoking cessation among DR-TB inpatients at a hospital in Durban, South Africa. METHODS: A qualitative design using in-depth interviews with a purposive sample of 20 DR-TB inpatients was employed...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29218837/asthma-in-children-and-adolescents-with-type-1-diabetes-in-germany-and-austria-frequency-and-metabolic-control
#10
Thomas Hörtenhuber, Wieland Kiess, Elke Fröhlich-Reiterer, Klemens Raile, Rainer Stachow, Esther Bollow, Birgit Rami-Merhar, Reinhard W Holl
OBJECTIVE: To investigate the prevalence of asthma in young patients with type 1 diabetes mellitus (T1D) from Austria and Germany and its influence on their metabolic control. METHODS: This prospective, multicenter observational cohort study was based on the DPV-registry (German/Austrian DPV initiative) including 51 926 patients with T1D (<20 years). All clinical data were documented prospectively. To identify patients with additional asthma, the entry of the diagnosis asthma as well as asthma medication was used for classification...
December 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29217200/timing-is-everything-reiterative-wnt-bmp-and-ra-signaling-regulate-developmental-competence-during-endoderm-organogenesis
#11
Scott A Rankin, Kyle W McCracken, David M Luedeke, Lu Han, James M Wells, John M Shannon, Aaron M Zorn
A small number of signaling pathways are used repeatedly during organogenesis, and they can have drastically different effects on the same population of cells depending on the embryonic stage. How cellular competence changes over developmental time is not well understood. Here we used Xenopus, mouse, and human pluripotent stem cells to investigate how the temporal sequence of Wnt, BMP, and retinoic acid (RA) signals regulates endoderm developmental competence and organ induction, focusing on respiratory fate...
December 4, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29215067/profiling-invasive-plasmodium-falciparum-merozoites-using-an-integrated-omics-approach
#12
Krishan Kumar, Prakash Srinivasan, Michael J Nold, J Kathleen Moch, Karine Reiter, Dan Sturdevant, Thomas D Otto, R Burke Squires, Raul Herrera, Vijayaraj Nagarajan, Julian C Rayner, Stephen F Porcella, Scott J Geromanos, J David Haynes, David L Narum
The symptoms of malaria are brought about by blood-stage parasites, which are established when merozoites invade human erythrocytes. Our understanding of the molecular events that underpin erythrocyte invasion remains hampered by the short-period of time that merozoites are invasive. To address this challenge, a Plasmodium falciparum gamma-irradiated long-lived merozoite (LLM) line was developed and investigated. Purified LLMs invaded erythrocytes by an increase of 10-300 fold compared to wild-type (WT) merozoites...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29213521/distinct-phospho-tdp-43-brain-distribution-in-two-cases-of-ftd-one-associated-with-als
#13
Álvaro C B Guedes, Ricardo Santin, André S R Costa, Keli C Reiter, Arlete Hilbig, Liana L Fernandez
INTRODUCTION: TDP-43 is an intranuclear protein involved in many cellular processes. When altered, it shows a change in pattern of distribution, as well as in functioning, throughout the Central Nervous System structures. Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS) are examples of TDP-43 proteinopathy. These disorders form a clinical spectrum, with some patients having a pure cognitive disorder while others also exhibit motor features. METHODS: We studied two donated brains from patients with a diagnosis of Frontotemporal Dementia (FTD), one of which was associated with ALS (ALS-FTD)...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29212031/integration-of-gpcr-signaling-and-sorting-from-very-early-endosomes-via-opposing-appl1-mechanisms
#14
Silvia Sposini, Frederic G Jean-Alphonse, Mohammed A Ayoub, Affiong Oqua, Camilla West, Stuart Lavery, Jan J Brosens, Eric Reiter, Aylin C Hanyaloglu
Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs). Heterogeneity in the endosomal network enables GPCR activity to be spatially restricted between early endosomes (EEs) and the recently discovered endosomal compartment, the very early endosome (VEE). However, the molecular machinery driving GPCR activity from the VEE is unknown. Using luteinizing hormone receptor (LHR) as a prototype GPCR for this compartment, along with additional VEE-localized GPCRs, we identify a role for the adaptor protein APPL1 in rapid recycling and endosomal cAMP signaling without impacting the EE-localized β2-adrenergic receptor...
December 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/29209352/melatonin-attenuates-potato-late-blight-by-disrupting-cell-growth-stress-tolerance-fungicide-susceptibility-and-homeostasis-of-gene-expression-in-phytophthora-infestans
#15
Shumin Zhang, Xianzhe Zheng, Russel J Reiter, Shun Feng, Ying Wang, Sen Liu, Liang Jin, Zhengguo Li, Raju Datla, Maozhi Ren
Phytophthora infestans (P. infestans) is the causal agent of potato late blight, which caused the devastating Irish Potato Famine during 1845-1852. Until now, potato late blight is still the most serious threat to potato growth and has caused significant economic losses worldwide. Melatonin can induce plant innate immunity against pathogen infection, but the direct effects of melatonin on plant pathogens are poorly understood. In this study, we investigated the direct effects of melatonin on P. infestans. Exogenous melatonin significantly attenuated the potato late blight by inhibiting mycelial growth, changing cell ultrastructure, and reducing stress tolerance of P...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29207774/a-diagnostic-surprise-for-a-right-iliac-fossa-mass-a-perforated-ileal-gastrointestinal-stromal-tumour
#16
J Sanjay Prakash, Anita Samraj, G Sabarish Kumar, R Vijai
Gastrointestinal Stromal Tumours (GISTs) are tumours of the gut found mostly in stomach and small intestine. The complications are Gastrointestinal (GI) bleeding, obstruction, pain and rarely perforation. We are reporting an abnormal presentation of GIST masquerading as an acute abdomen with Right Iliac Fossa (RIF) mass in 60-year-old lady. Contrast Enhanced Computed Tomography (CECT) of abdomen revealed a peripherally enhancing encapsulated abscess in RIF in close contact with base of caecum and adjacent peritonitis suggesting caecal perforation...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206995/concordance-of-circulating-tumor-dna-and-matched-metastatic-tissue-biopsy-in-prostate-cancer
#17
Alexander W Wyatt, Matti Annala, Rahul Aggarwal, Kevin Beja, Felix Feng, Jack Youngren, Adam Foye, Paul Lloyd, Matti Nykter, Tomasz M Beer, Joshi J Alumkal, George V Thomas, Robert E Reiter, Matthew B Rettig, Christopher P Evans, Allen C Gao, Kim N Chi, Eric J Small, Martin E Gleave
Background: Real-time knowledge of the somatic genome can influence management of patients with metastatic castration-resistant prostate cancer (mCRPC). While routine metastatic tissue biopsy is challenging in mCRPC, plasma circulating tumor DNA (ctDNA) has emerged as a minimally invasive tool to sample the tumor genome. However, no systematic comparisons of matched "liquid" and "solid" biopsies have been performed that would enable ctDNA profiling to replace the need for direct tissue sampling...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29204919/prognostic-value-of-the-lymph-node-ratio-in-oropharyngeal-carcinoma-stratified-for-hpv-status
#18
Christian Jacobi, Josepha Rauch, Jan Hagemann, Thomas Lautz, Maximilian Reiter, Philipp Baumeister
OBJECTIVE: Lymph node ratio (LNR) was shown to be a prognostic factor in laryngeal and oral cavity primaries. The purpose of this study was to investigate the impact of the lymph node ratio in oropharyngeal squamous cell carcinoma (OPSCC) with a high incidence of HPV-related disease. Therefore, the role of LNR was evaluated as an additional predictive parameter to the 8th edition of AJCC TNM staging system. METHODS: From December 2009 to August 2015, patients diagnosed with primary oropharyngeal squamous cell carcinoma were prospectively enrolled...
December 4, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29203377/proposed-terminology-and-classification-of-pre-malignant-neoplastic-conditions-a-consensus-proposal
#19
REVIEW
Peter Valent, Cem Akin, Michel Arock, Christoph Bock, Tracy I George, Stephen J Galli, Jason Gotlib, Torsten Haferlach, Gregor Hoermann, Olivier Hermine, Ulrich Jäger, Lukas Kenner, Hans Kreipe, Ravindra Majeti, Dean D Metcalfe, Alberto Orfao, Andreas Reiter, Wolfgang R Sperr, Philipp B Staber, Karl Sotlar, Charles Schiffer, Giulio Superti-Furga, Hans-Peter Horny
Cancer evolution is a step-wise non-linear process that may start early in life or later in adulthood, and includes pre-malignant (indolent) and malignant phases. Early somatic changes may not be detectable or are found by chance in apparently healthy individuals. The same lesions may be detected in pre-malignant clonal conditions. In some patients, these lesions may never become relevant clinically whereas in others, they act together with additional pro-oncogenic hits and thereby contribute to the formation of an overt malignancy...
November 26, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29203148/diabetic-retinopathy-pathogenesis-and-the-ameliorating-effects-of-melatonin-involvement-of-autophagy-inflammation-and-oxidative-stress
#20
REVIEW
Ehsan Dehdashtian, Saeed Mehrzadi, Bahman Yousefi, Azam Hosseinzadeh, Russel J Reiter, Majid Safa, Habib Ghaznavi, Masood Naseripour
Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus (DM), remains as one of the major causes of vision loss worldwide. The release of pro-inflammatory cytokines and the adhesion of leukocytes to retinal capillaries are initial events in DR development. Inflammation, ER stress, oxidative stress and autophagy are major causative factors involved in the pathogenesis of DR. Diabetes associated hyperglycemia leads to mitochondrial electron transport chain dysfunction culminating in a rise in ROS generation...
December 1, 2017: Life Sciences
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