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https://www.readbyqxmd.com/read/28549578/pediatric-out-of-hospital-cardiac-arrest-caused-by-left-coronary-artery-agenesis-with-primary-shockable-rhythm-a-brief-report
#1
Moritz Weigeldt, Sabine Lahmann, Konstantin Krieger, Sebastian Buttenberg, Volker Stephan, Brigitte Stiller, Dirk Stengel
BACKGROUND: To illustrate a rare cause of out-of-hospital cardiac arrest in children, its differential diagnoses, emergency and subsequent treatment at various steps in the rescue chain, and potential outcomes. CASE PRESENTATION: A 4-year-old boy with unknown agenesis of the left coronary ostium sustained out-of-hospital cardiac arrest. Bystander cardio-pulmonary resuscitation was initiated and defibrillation was performed via an automated external defibrillator (AED) shortly after paramedics arrived at the scene, restoring sinus rhythm and spontaneous circulation...
May 11, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28546900/response-to-kruse-plass-et-al-2017-regarding-the-risk-to-non-target-lepidopteran-larvae-exposed-to-pollen-from-one-or-more-of-three-bt-maize-events-mon810-bt11-and-1507
#2
Joe N Perry, Paolo Barberi, Detlef Bartsch, A N E Birch, Achim Gathmann, Jozsef Kiss, Barbara Manachini, Marco Nuti, Stefan Rauschen, Joachim Schiemann, Mechthild Schuppener, Jeremy Sweet, Christoph C Tebbe, Fabio Veronesi
We respond to the paper of Kruse-Plass et al. (Environ Sci Eur 29:12, 2017), published in this journal, regarding the risk to non-target lepidopteran larvae exposed to pollen from one or more of three Bt maize events (MON810, Bt11 and 1507). We emphasise that what is important for environmental risk assessment is not the number of pollen grains per se, but the degree of exposure of a NT lepidopteran larva to Bt protein contained in maize pollen. The main text of this response deals with general issues which Kruse-Plass et al...
2017: Environmental Sciences Europe
https://www.readbyqxmd.com/read/28546222/prevalence-of-celiac-disease-in-52-721-youth-with-type-1-diabetes-international-comparison-across-three-continents
#3
Maria E Craig, Nicole Prinz, Claire T Boyle, Fiona M Campbell, Timothy W Jones, Sabine E Hofer, Jill H Simmons, Naomi Holman, Elaine Tham, Elke Fröhlich-Reiterer, Stephanie DuBose, Helen Thornton, Bruce King, David M Maahs, Reinhard W Holl, Justin T Warner
OBJECTIVE: Celiac disease (CD) has a recognized association with type 1 diabetes. We examined international differences in CD prevalence and clinical characteristics of youth with coexisting type 1 diabetes and CD versus type 1 diabetes only. RESEARCH DESIGN AND METHODS: Data sources were as follows: the Prospective Diabetes Follow-up registry (Germany/Austria); the T1D Exchange Clinic Network (T1DX) (U.S.); the National Paediatric Diabetes Audit (U.K. [England/Wales]); and the Australasian Diabetes Data Network (ADDN) (Australia)...
May 25, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28545582/gender-differences-in-hypertension-awareness-antihypertensive-use-and-blood-pressure-control-in-bangladeshi-adults-findings-from-a-national-cross-sectional-survey
#4
Muntasirur Rahman, Gail Williams, Abdullah Al Mamun
BACKGROUND: Bangladesh is facing an epidemiological transition with a growing burden of non-communicable diseases. Traditionally, hypertension and associated complications in women receive less recognition, and there is a dearth of related publications. The study aims to explore gender differences in high blood pressure awareness and antihypertensive use in Bangladeshi adults at the community level. Another objective is to identify factors associated with uncontrolled hypertension among antihypertensive users...
May 25, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28544018/next-generation-nucleic-acid-aptamers-with-two-base-modified-nucleotides-improve-the-binding-affinity-and-potency
#5
Rakesh Naduvile Veedu, Hadi AlShamaileh
Aptamers are single-stranded oligonucleotides (RNA or DNA) that can bind to their targets with high affinities and specificities because of their ability to adopt three-dimensional shapes in solution. Traditionally, aptamers are developed by SELEX (Systematic Evolution of Ligands by Exponential enrichment), a reiterative process involving selection by target molecule incubation with an oligonucleotide library and enrichment of the selected oligonucleotides by amplification. One drawback of current aptamer selection approach is the lack of diversity in the nucleic acid library with only four nucleobases compositions...
May 24, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28542896/diverse-responses-of-species-to-landscape-fragmentation-in-a-simple-food-chain
#6
Jinbao Liao, Daniel Bearup, Bernd Blasius
1.Habitat destruction, characterized by habitat loss and fragmentation, is a key driver of species extinction in spatial extended communities. Recently, there has been some progress in the theory of spatial food webs, however to date practically little is known about how habitat configurational fragmentation influences multi-trophic food web dynamics. 2.To explore how habitat fragmentation affects species persistence in food webs, we introduce a modelling framework that describes the site occupancy of species in a tri-trophic system...
May 24, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28542807/genetic-diversity-virulotyping-and-antimicrobial-resistance-susceptibility-of-yersinia-enterocolitica-isolated-from-pigs-and-porcine-products-in-malaysia
#7
Kwai Lin Thong, Lai Kuan Tan, Peck Toung Ooi
BACKGROUND: The objectives of this study were to determine the antimicrobial resistance, virulotypes and genetic diversity of Yersinia enterocolitica isolated from uncooked porcine food and live pigs in Malaysia. RESULTS: Thirty-two non-repeat Y. enterocolitica strains of three bioserotypes (3 variant/O:3, n=27; 1B/O:8, n=3; 1A/O:5, n=2) were analysed. About 90% of strains were multidrug-resistant with MAR index <0.2 and majority of the strains were resistant to nalidixic acid, clindamycin, ampicillin, ticarcillin, tetracycline and amoxicillin...
May 24, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28535129/suicide-and-mental-disorders-a-discourse-of-politics-power-and-vested-interests
#8
Heidi Hjelmeland, Birthe L Knizek
One of the most well-established "truths" in suicidology is that mental disorders play a significant role in at least 90% of suicides, and a causal relationship between the two is often implied. In this essay, we argue that the evidence base for this "truth" is weak and that there is much research questioning the 90% statistic. Based on numerous examples, we also argue that ideology, politics, power, and vested interests among influential professionals in the field obstruct argument-based discussion of this issue...
May 23, 2017: Death Studies
https://www.readbyqxmd.com/read/28531236/psychosine-enhances-the-shedding-of-membrane-microvesicles-implications-in-demyelination-in-krabbe-s-disease
#9
Ludovic D'Auria, Cory Reiter, Emma Ward, Ana Lis Moyano, Michael S Marshall, Duc Nguyen, Giuseppe Scesa, Zane Hauck, Richard van Breemen, Maria I Givogri, Ernesto R Bongarzone
In prior studies, our laboratory showed that psychosine accumulates and disrupts lipid rafts in brain membranes of Krabbe's disease. A model of lipid raft disruption helped explaining psychosine's effects on several signaling pathways important for oligodendrocyte survival and differentiation but provided more limited insight in how this sphingolipid caused demyelination. Here, we have studied how this cationic inverted coned lipid affects the fluidity, stability and structure of myelin and plasma membranes...
2017: PloS One
https://www.readbyqxmd.com/read/28530684/tackling-hiv-and-aids-contributions-by-non-human-primate-models
#10
Koen K A Van Rompay
During the past three decades, non-human primate (NHP) models have gained an increasing importance in HIV basic and translational research. In contrast to natural host models, infection of macaques with virulent simian or simian-human immunodeficiency viruses (SIV, SHIV) results in a disease that closely resembles HIV infection and AIDS. Although there is no perfect animal model, and each of the available models has its benefits and limitations, carefully designed NHP studies with selection of experimental variables have unraveled important questions of basic pathogenesis and have provided the tools to explore and screen intervention strategies...
May 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28529147/norursodeoxycholic-acid-improves-cholestasis-in-primary-sclerosing-cholangitis
#11
Peter Fickert, Gideon M Hirschfield, Gerald Denk, Hanns-Ulrich Marschall, Istvan Altorjay, Martti Färkkilä, Christoph Schramm, Ulrich Spengler, Roger Chapman, Annika Bergquist, Erik Schrumpf, Frederik Nevens, Palak Trivedi, Florian P Reiter, Istvan Tornai, Emina Halilbasic, Roland Greinwald, Markus Pröls, Michael P Manns, Michael Trauner
Primary sclerosing cholangitis (PSC) represents a devastating bile duct disease lacking effective medical therapy. 24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties in a preclinical PSC mouse model. AIM: To evaluate the safety and efficacy of 3 doses of oral norUDCA (500mg/d, 1000mg/d or 1500 mg/d) compared with placebo in PSC in a RCT including 38centers from 12European countries...
May 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28528861/mechanism-of-melatonin-protection-against-copper-ascorbate-induced-oxidative-damage-in-vitro-through-isothermal-titration-calorimetry
#12
Arnab K Ghosh, Shamreen Naaz, Bharati Bhattacharjee, Nirajan Ghosal, Aindrila Chattopadhyay, Souvik Roy, Russel J Reiter, Debasish Bandyopadhyay
AIMS: Involvement of oxidative stress in cardiovascular diseases is well established. Melatonin's role as an antioxidant and free radical scavenger via its receptor dependent and receptor independent pathways is well known. The aim of this study is to identify and elaborate upon a third mechanism by which melatonin is able to abrogate oxidative stress. MAIN METHODS: Oxidative stress was induced in vitro, by copper (0.2mM)-ascorbate (1mM) in isolated goat heart mitochondria, cytosol and peroxisomes and they were co-incubated with graded doses of melatonin...
May 18, 2017: Life Sciences
https://www.readbyqxmd.com/read/28528612/reiter-s-syndrome
#13
Mark Bernhardt
No abstract text is available yet for this article.
2017: Skinmed
https://www.readbyqxmd.com/read/28525759/modeling-rett-syndrome-using-talen-edited-mecp2-mutant-cynomolgus-monkeys
#14
Yongchang Chen, Juehua Yu, Yuyu Niu, Dongdong Qin, Hailiang Liu, Gang Li, Yingzhou Hu, Jiaojian Wang, Yi Lu, Yu Kang, Yong Jiang, Kunhua Wu, Siguang Li, Jingkuan Wei, Jing He, Junbang Wang, Xiaojing Liu, Yuping Luo, Chenyang Si, Raoxian Bai, Kunshan Zhang, Jie Liu, Shaoyong Huang, Zhenzhen Chen, Shuang Wang, Xiaoying Chen, Xinhua Bao, Qingping Zhang, Fuxing Li, Rui Geng, Aibin Liang, Dinggang Shen, Tianzi Jiang, Xintian Hu, Yuanye Ma, Weizhi Ji, Yi Eve Sun
Gene-editing technologies have made it feasible to create nonhuman primate models for human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN-edited MECP2 mutant cynomolgus monkeys serving as a model for a neurodevelopmental disorder, Rett syndrome (RTT), which is caused by loss-of-function mutations in the human MECP2 gene. Male mutant monkeys were embryonic lethal, reiterating that RTT is a disease of females. Through a battery of behavioral analyses, including primate-unique eye-tracking tests, in combination with brain imaging via MRI, we found a series of physiological, behavioral, and structural abnormalities resembling clinical manifestations of RTT...
May 18, 2017: Cell
https://www.readbyqxmd.com/read/28524366/contrasting-hcv-and-hiv-seroepidemiology-in-11-years-of-blood-donors-screening-in-brazil
#15
J E Levi, S M Lira, C B Bub, M B Polite, C C Terzian, J M Kutner
BACKGROUND: Blood donors are, in principle, healthy individuals who may be revealed as infectious for blood-borne agents by the laboratory screening process, depicting the asymptomatic burden of the disease. Therefore, monitoring hepatitis C virus (HCV)-infected donor and human immunodeficiency virus (HIV)-infected donor and associating to their demographical and behavioural characteristics may shed light on the dynamics and contemporary changes in these viruses' epidemiology. METHODS: Donors presenting repeatedly reactive HCV or HIV serology/nucleic acid testing (NAT) screening results were submitted to confirmatory testing...
May 19, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28515610/hyperemia-causing-delayed-recovery-in-traumatic-brain-injury
#16
Shalini Nair, Ramanan Rajagopal
Subarachnoid hemorrhage is a common manifestation of traumatic brain injury. A clinical deterioration in Glasgow Coma Scale score without an accompanying radiological worsening is suggestive of vasospasm. However, hyperemia could be another possibility which can easily be considered with corroborating transcranial Doppler (TCD) features. This case report reiterates the value of TCD in such instances.
April 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28515063/learning-to-like-vegetables-during-breastfeeding-a-randomized-clinical-trial-of-lactating-mothers-and-infants
#17
Julie A Mennella, Loran M Daniels, Ashley R Reiter
Background: What lactating mothers eat flavors breast milk and, in turn, modifies their infants' acceptance of similarly flavored foods.Objective: We sought to determine the effects of the timing and duration of eating a variety of vegetables during breastfeeding on the liking of vegetables in both members of the dyad.Design: We conducted a randomized controlled study of 97 mother-infant dyads. Lactating mothers drank vegetable, beet, celery, and carrot juices for 1 mo beginning at 0.5, 1.5, or 2.5 mo postpartum or for 3 mo beginning at 0...
May 17, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28510014/biosensor-binding-data-and-its-applicability-to-the-determination-of-active-concentration
#18
REVIEW
Robert Karlsson
Protein concentration data are required for understanding protein interactions and are a prerequisite for the determination of affinity and kinetic properties. It is vital for the judgment of protein quality and for monitoring the effect of therapeutic agents. Protein concentration values are typically obtained by comparison to a standard and derived from a standard curve. The use of a protein standard is convenient, but may not give reliable results if samples and standards behave differently. In other cases, a standard preparation may not be available and has to be established and validated...
December 2016: Biophysical Reviews
https://www.readbyqxmd.com/read/28508804/ehealth-networking-information-systems-the-new-quality-of-information-exchange
#19
Karin Messer-Misak, Christoph Reiter
BACKGROUND: The development and introduction of platforms that enable interdisciplinary exchange on current developments and projects in the area of eHealth have been stimulated by different authorities. OBJECTIVES: The aim of this project was to develop a repository of eHealth projects that will make the wealth of eHealth projects visible and enable mutual learning through the sharing of experiences and good practice. METHODS: The content of the database and search criteria as well as their categories were determined in close co-ordination and cooperation with stakeholders from the specialist areas...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28505751/anomalous-scaling-of-stochastic-processes-and-the-moses-effect
#20
Lijian Chen, Kevin E Bassler, Joseph L McCauley, Gemunu H Gunaratne
The state of a stochastic process evolving over a time t is typically assumed to lie on a normal distribution whose width scales like t^{1/2}. However, processes in which the probability distribution is not normal and the scaling exponent differs from 1/2 are known. The search for possible origins of such "anomalous" scaling and approaches to quantify them are the motivations for the work reported here. In processes with stationary increments, where the stochastic process is time-independent, autocorrelations between increments and infinite variance of increments can cause anomalous scaling...
April 2017: Physical Review. E
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