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https://www.readbyqxmd.com/read/29046268/multisite-semiautomated-clinical-data-repository-for-duplication-15q-syndrome-study-protocol-and-early-uses
#1
Oluwaseun Jessica Ajayi, Ebony Jeannae Smith, Teeradache Viangteeravat, Eunice Y Huang, Naga Satya V Rao Nagisetty, Nora Urraca, Laina Lusk, Brenda Finucane, Dimitrios Arkilo, Jennifer Young, Shafali Jeste, Ronald Thibert, Lawrence T Reiter
BACKGROUND: Chromosome 15q11.2-q13.1 duplication syndrome (Dup15q syndrome) is a rare disorder caused by duplications of chromosome 15q11.2-q13.1, resulting in a wide range of developmental disabilities in affected individuals. The Dup15q Alliance is an organization that provides family support and promotes research to improve the quality of life of patients living with Dup15q syndrome. Because of the low prevalence of this condition, the establishment of a single research repository would have been difficult and more time consuming without collaboration across multiple institutions...
October 18, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29045739/assessment-of-ketamine-binding-of-the-serotonin-transporter-in-humans-with-positron-emission-tomography
#2
Marie Spies, Gregory M James, Neydher Berroterán-Infante, Harald Ibeschitz, Georg S Kranz, Jakob Unterholzner, Mathis Godbersen, Gregor Gryglewski, Marius Hienert, Johannes Jungwirth, Verena Pichler, Birgit Reiter, Leo Silberbauer, Dietmar Winkler, Markus Mitterhauser, Thomas Stimpfl, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberger
Background: Comprehensive description of ketamine's molecular binding profile becomes increasingly pressing as use in real life patient cohorts widens. Animal studies attribute a significant role in the substance's antidepressant effects to the serotoninergic system. The serotonin transporter (SERT) is a highly relevant target in this context because it is central to depressive pathophysiology and treatment. This is to our knowledge the first study investigating ketamine's SERT binding in-vivo in humans...
October 16, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29044421/heterogeneous-hcg-and-hmg-commercial-preparations-result-in-different-intracellular-signalling-but-induce-a-similar-long-term-progesterone-response-in-vitro
#3
Laura Riccetti, Danièle Klett, Mohammed Akli Ayoub, Thomas Boulo, Elisa Pignatti, Simonetta Tagliavini, Manuela Varani, Tommaso Trenti, Alessia Nicoli, Francesco Capodanno, Giovanni Battista La Sala, Eric Reiter, Manuela Simoni, Livio Casarini
STUDY QUESTION: Are four urinary hCG/menotropin (hMG) and one recombinant preparation characterized by different molecular features and do they mediate specific intracellular signaling and steroidogenesis? SUMMARY ANSWER: hCG and hMG preparations have heterogeneous compositions and mediate preparation-specific cell signaling and early steroidogenesis, although similar progesterone plateau levels are achieved in 24 h-treated human primary granulosa cells in vitro...
October 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29038307/branching-morphogenesis-in-the-developing-kidney-is-governed-by-rules-that-pattern-the-ureteric-tree
#4
James Lefevre, Kieran M Short, Timothy O Lamberton, Odyssé Michos, Daniel Graf, Ian M Smyth, Nicholas A Hamilton
Metanephric kidney development is orchestrated by the iterative branching morphogenesis of the ureteric bud. We describe an underlying patterning associated with the ramification of this structure and show that this pattern is conserved between developing kidneys, in different parts of the organ and across developmental time. This regularity is associated with a highly reproducible branching asymmetry that is consistent with locally operative growth mechanisms. We then develop a class of tip state models to represent elaboration of the ureteric tree and describe rules for "half delay" branching morphogenesis that describe almost perfectly the patterning of this structure...
October 16, 2017: Development
https://www.readbyqxmd.com/read/29037484/australian-midwives-views-and-experiences-of-practice-and-politics-related-to-water-immersion-for-labour-and-birth-a-web-based-survey
#5
Megan Cooper, Jane Warland, Helen McCutcheon
BACKGROUND: There is little published research that has examined practitioners' views and experiences of pain relieving measures commonly used during labour and birth, particularly for non-pharmacological measures such as water immersion. Furthermore, there is minimal published research examining the process of policy and guideline development, that is, the translation of published research to usable practice guidance. AIMS: The aims of phase three of a larger study were to explore midwives knowledge, experiences and support for the option of water immersion for labour and birth in practice and their involvement, if any, in development of policy and guidelines pertaining to the option...
October 13, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29036889/single-administration-of-melatonin-modulates-the-nitroxidergic-system-at-the-peripheral-level-and-reduces-thermal-nociceptive-hypersensitivity-in-neuropathic-rats
#6
Elisa Borsani, Barbara Buffoli, Veronica Bonazza, Russel J Reiter, Rita Rezzani, Luigi F Rodella
Neuropathic pain is a severe condition with unsatisfactory treatments. Melatonin, an indolamine, seems to be a promising molecule suitable for this purpose due to its well-known anti-inflammatory, analgesic, and antioxidant effects, as well as its modulation of the nitroxidergic system. Nevertheless, the data on its mechanism of action and potentialities are currently insufficient in this pathology, especially at the peripheral level. Thus, this work evaluated the effect of a single administration of melatonin in an established mononeuropathy pain model that monitors the behaviour and the changes in the nitroxidergic system in dorsal root ganglia and skin, which are affected by nervous impairment...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29035029/multilayer-ceramic-magnetoelectric-composites-with-tailored-interfaces-for-enhanced-response
#7
Harvey Amorín, Jesús Ricote, Iván San-Felipe, Norberto Salazar, Rubén Del Campo, Yonny Romaguera-Barcelay, Javier Pérez de la Cruz, Pablo Ramos, Eladio Vila, Alicia Castro, Miguel Algueró
Composite materials consisting of two dissimilar ferroic phases are an excellent alternative to single-phase multiferroics for a wide range of magnetoelectric technologies. In composites with strain-mediated magnetoelectric coupling the response is strongly dependent on the characteristics of the interface between the two mechanically coupled phases. Among the different material approaches considered, cofired ceramic composites offer improved reliability in applications, and are more adequate for free-forming and miniaturization...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29031172/a-parapharyngeal-space-schwannoma-arising-from-the-vagus-nerve-a-case-report
#8
Conor Carroll, Manish Jagatiya, Dia Kamel, Jamal Siddiqi
INTRODUCTION: Tumours of the parapharyngeal space are rare. Only 0.5% of head and neck tumours occur in this space. Surgical excision of parapharyngeal space lesions is challenging because of the anatomical complexity of the area. PRESENTATION OF CASE: A 31-year-old male patient was referred by his general dental practitioner for removal of lower wisdom teeth due to multiple episodes of pericoronitis. At the initial examination, an incidental finding was made of a large fluctuant posterior oropharyngeal swelling...
October 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29025688/altered-medial-frontal-feedback-learning-signals-in-anorexia-nervosa
#9
Fabio Bernardoni, Daniel Geisler, Joseph A King, Amir-Homayoun Javadi, Franziska Ritschel, Julia Murr, Andrea M F Reiter, Veit Rössner, Michael N Smolka, Stefan Kiebel, Stefan Ehrlich
BACKGROUND: In their relentless pursuit of thinness, individuals with anorexia nervosa (AN) engage in maladaptive behaviors (restrictive food choices and overexercising) that may originate in altered decision making and learning. METHODS: In this functional magnetic resonance imaging study, we employed computational modeling to elucidate the neural correlates of feedback learning and value-based decision making in 36 female patients with AN and 36 age-matched healthy volunteers (12-24 years)...
August 30, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29023413/diallylthiosulfinate-allicin-a-volatile-antimicrobial-from-garlic-allium-sativum-kills-human-lung-pathogenic-bacteria-including-mdr-strains-as-a-vapor
#10
Jana Reiter, Natalja Levina, Mark van der Linden, Martin Gruhlke, Christian Martin, Alan J Slusarenko
Garlic (Allium sativum) has potent antimicrobial activity due to allicin (diallylthiosulfinate) synthesized by enzyme catalysis in damaged garlic tissues. Allicin gives crushed garlic its characteristic odor and its volatility makes it potentially useful for combating lung infections. Allicin was synthesized (>98% pure) by oxidation of diallyl disulfide by H₂O₂ using formic acid as a catalyst and the growth inhibitory effect of allicin vapor and allicin in solution to clinical isolates of lung pathogenic bacteria from the genera Pseudomonas, Streptococcus, and Staphylococcus, including multi-drug resistant (MDR) strains, was demonstrated...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29022978/freeze-dried-strawberry-and-blueberry-attenuates-diet-induced-obesity-and-insulin-resistance-in-rats-by-inhibiting-adipogenesis-and-lipogenesis
#11
Paula Aranaz, Ana Romo-Hualde, María Zabala, David Navarro-Herrera, Marina Ruiz de Galarreta, Ana Gloria Gil, J Alfredo Martinez, Fermín I Milagro, Carlos J González-Navarro
Obesity and type 2-diabetes are becoming a worldwide health problem, reiterating the importance of alternative therapies to tackle their progression. Here, we hypothesized that supplementation of diet with 6% w/w of a freeze-dried strawberry-blueberry (5 : 1) powder (FDSB) could exert beneficial metabolic effects on Wistar rats. FDSB-supplemented animals experienced significantly reduced body weight gain, food efficiency and visceral adiposity accumulation in two independent experiments. FDSB supplementation also contributed to lower area under the curve after an intraperitoneal GTT and reduced serum insulin levels and an insulin resistance index (IR-HOMA) in HFS diet-fed animals, together with reduced plasma MCP-1 inflammation marker concentrations...
October 12, 2017: Food & Function
https://www.readbyqxmd.com/read/29021156/safety-and-accuracy-of-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms-to-identify-highly-pathogenic-organisms
#12
James T Rudrik, Marty K Soehnlen, Michael J Perry, Maureen Sullivan, Wanda Reiter-Kintz, Philip A Lee, Denise Pettit, Anthony Tran, Erin Swaney
Matrix-assisted laser desorption ionization -- time of flight mass spectrometry (MALDI-TOF MS) sample preparation methods including the direct, on-plate formic acid, and ethanol/formic acid tube extraction were evaluated for their ability to render highly pathogenic organisms non-viable and safe for handling in a Biosafety Level-2 laboratory. Of these, the tube extraction procedure was the most successful, with none of the tested strains surviving this sample preparation method. Tube extracts from several agents of bioterrorism and their near neighbors were analyzed in an eight laboratory study to examine the utility of the Bruker Biotyper and Vitek MS MALDI-TOF MS systems and their IVD, research use only, and Security-Relevant databases, as applicable, to accurately identify these agents...
October 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29019477/comparing-axis-ii-scores-according-to-the-rdc-tmd-and-dc-tmd-in-israeli-patients
#13
Shoshana Reiter, Ilana Eli, Pessia Friedman-Rubin, Alona Emodi-Perlman, Tomer Ziv-Baran, Ephraim Winocur
AIMS: To use the Symptom Checklist-90-Revised (SCL-90-R)-based instruments of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and the Primary Care Evaluation of Mental Disorders (PRIME-MD)-based instruments of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) in order to compare these Axis II scores in temporomandibular disorder (TMD) patients. METHODS: Demographic and socioeconomic data, Axis I diagnoses, and Axis II evaluations (depression, nonspecific physical symptoms, anxiety, and Graded Chronic Pain Scale [GCPS]) were compared between two groups of patients-142 TMD patients diagnosed according to the RDC/TMD (RDC group) and 157 TMD patients diagnosed according to the DC/TMD (DC group)...
October 10, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29017197/-500-years-of-reformation-the-history-of-martin-luther-s-pathography-and-its-ethical-implications
#14
Birgit Braun, Thomas Loew
Introduction In the context of the 500th anniversary of the Reformation, it is time to take a survey of the history of Martin Luther's (1483-1546) pathography and to deduce possible conclusions from it for psychiatric practice. Results In a 1035-page work written in German between 1937 and 1941, the Dane Paul Reiter retrospectively diagnosed Luther as manic-depressive. In 1956, Grossmann was unable to prove persistent synchronicity of depressive mood and reduced motivation in Luther in the key years 1527 and 1528, which led him to conclude that Luther had a cyclothymic personality with a pyknic constitution...
October 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29016856/neuronal-overexpression-of-ube3a-isoform-2-causes-behavioral-impairments-and-neuroanatomical-pathology-relevant-to-15q11-2-q13-3-duplication-syndrome
#15
Nycole A Copping, Sarah G B Christian, Dylan J Ritter, M Saharul Islam, Nathalie Buscher, Dorota Zolkowska, Michael C Pride, Elizabeth L Berg, Janine M LaSalle, Jacob Ellegood, Jason P Lerch, Lawrence T Reiter, Jill L Silverman, Scott V Dindot
Maternally derived copy number gains of human chromosome 15q11.2-q13.3 (Dup15q syndrome or Dup15q) cause intellectual disability, epilepsy, developmental delay, hypotonia, speech impairments, and minor dysmorphic features. Dup15q syndrome is one of the most common and penetrant chromosomal abnormalities observed in individuals with autism spectrum disorder (ASD). Although ∼40 genes are located in the 15q11.2-q13.3 region, overexpression of the ubiquitin-protein E3A ligase (UBE3A) gene is thought to be the predominant molecular cause of the phenotypes observed in Dup15q syndrome...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29016240/reiterated-concerns-and-further-challenges-for-mindfulness-and-meditation-research-a-reply-to-davidson-and-dahl
#16
Nicholas T Van Dam, Marieke K van Vugt, David R Vago, Laura Schmalzl, Clifford D Saron, Andrew Olendzki, Ted Meissner, Sara W Lazar, Jolie Gorchov, Kieran C R Fox, Brent A Field, Willoughby B Britton, Julie A Brefczynski-Lewis, David E Meyer
In response to our article, Davidson and Dahl offer commentary and advice regarding additional topics crucial to a comprehensive prescriptive agenda for future research on mindfulness and meditation. Their commentary raises further challenges and provides an important complement to our article. More consideration of these issues is especially welcome because limited space precluded us from addressing all relevant topics. While we agree with many of Davidson and Dahl's suggestions, the present reply (a) highlights reasons why the concerns we expressed are still especially germane to mindfulness and meditation research (even though those concerns may not be entirely unique) and (b) gives more context to other issues posed by them...
September 1, 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28987063/dr-jekels-health-resort-in-bystra-near-bielsko-the-first-treatment-centre-which-adopted-psychoanalysis-in-poland
#17
REVIEW
Edyta Dembińska, Krzysztof Rutkowski
The paper sets out to present the history of a health resort and hydrotherapy centre in Bystra near Bielsko from 1898 to 1912. At that time Dr Ludwik Jekels, one of the Polish psychoanalysis forerunners, was the owner of the centre. Initially, Dr Jekels was very enthusiastic about climatic treatment and hydrotherapy, until 1905 when he got interested in psychoanalysis. Shortly afterwards he became its staunch supporter and adopted it as a curative procedure in his health resort. That was the first documented case of psychoanalysis use in Poland...
August 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28986509/why-targeting-psma-is-a-game-changer-in-the-management-of-prostate-cancer-%C3%A2-a-urologist-s-point-of-view
#18
Nicholas M Donin, Robert Reiter
Prostate-specific membrane antigen (PSMA), is a transmembrane glycoprotein that is highly expressed on prostate adenocarcinomas, exhibits only limited expression in benign and extra-prostatic tissues, and thus represents an ideal target for the diagnosis and management of prostate cancer. Since its discovery over 30 years ago, significant effort has been made to develop clinical technology targeting PSMA. The last 5 years have seen an explosion of development of new agents targeting PSMA for diagnostic and therapeutic use...
October 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28983060/results-and-conclusions-of-the-european-intergroup-euro-lb02-trial-in-children-and-adolescents-with-lymphoblastic-lymphoma
#19
Eva Landmann, Birgit Burkhardt, Martin Zimmermann, Ulrike Meyer, Wilhelm Woessmann, Wolfram Klapper, Grazyna Wrobel, Angelo Rosolen, Marta Pillon, Gabriele Escherich, Andishe Attarbaschi, Auke Beishuizen, Karin Mellgren, Robert Wynn, Richard Ratei, Adriana Plesa, Martin Schrappe, Alfred Reiter, Christophe Bergeron, Catherine Patte, Yves Bertrand
In the European Intergroup EURO-LB02 Trial, children and adolescents with lymphoblastic lymphoma underwent the Non-Hodgkin's Lymphoma-Berlin-Frankfurt-Munster protocol without prophylactic cranial radiotherapy. Primary aims were to test whether replacing prednisone with dexamethasone during induction increases EFS in the T-cell lymphoblastic lymphoma subgroup and whether therapy duration can be reduced from 24 to 18 months (factorial design, randomizations). These questions could not be answered due to premature closure of the trial...
October 5, 2017: Haematologica
https://www.readbyqxmd.com/read/28980129/rupture-of-the-aortic-root-a%C3%A2-rare-but-life-threatening-complication-of-transcatheter-aortic-valve-replacement
#20
Christian Reiter, Michael Grund, Alexander Nahler, Clemens Steinwender, Thomas Lambert
Transcatheter aortic valve replacement (TAVR) has been shown to be a valid treatment option for patients with significant symptomatic aortic valve stenosis and high surgical risk. Rupture of the aortic root is a rare but life-threatening complication that occurs in approximately 1% of procedures and usually manifests as an acute complication at the time of valve implantation; however, physicians should be aware of a potentially subacute onset, since early recognition and immediate management are crucial...
October 4, 2017: Wiener Klinische Wochenschrift
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