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JOURNAL ARTICLE
Chandan Noel Vincent, Aakash Venkatesan, Dinakar Rai, Arvind Kumar Sm
Aim The present study aims to look at the long-term clinical and radiological outcomes of surgically treated talus fractures. We have compared the outcomes and complications between simple and complex talar fracture patterns. Additionally, patients' ability to return to activity following surgical treatment of these fractures was also analysed. Materials and methods Retrospective analysis of surgically treated talus fractures at the PSG Institute of Medical Sciences and Research from 2012 to 2015. The fractures were classified as neck and body fractures...
April 2024: Curēus
#22
JOURNAL ARTICLE
Melinda M Rathkopf, Matt Reiter, Steve Dorman, Vinh T Nguyen, J Allen Meadows
No abstract text is available yet for this article.
April 7, 2024: Annals of Allergy, Asthma & Immunology
#23
JOURNAL ARTICLE
Johannes Lübke, Alicia Schmid, Deborah Christen, Hanneke N G Oude Elberink, Lambert F R Span, Marek Niedoszytko, Aleksandra Górska, Magdalena Lange, Karoline V Gleixner, Emir Hadzijusufovic, Alex Stefan, Irena Angelova-Fischer, Roberta Zanotti, Massimiliano Bonifacio, Patrizia Bonadonna, Khalid Shoumariyeh, Nikolas von Bubnoff, Sabine Müller, Cecelia Perkins, Chiara Elena, Luca Malcovati, Hans G Hagglund, Mattias Mattsson, Roberta Parente, Judit Varkonyi, Anna Belloni Fortina, Francesca Caroppo, Knut Brockow, Alexander Zink, Christine Breynaert, Toon Ieven, Akif Selim Yavuz, Michael Doubek, Vito Sabato, Tanja Schug, Karin Hartmann, Massimo Triggiani, Jason Gotlib, Olivier Hermine, Michel Arock, Hanneke C Kluin-Nelemans, Jens Peter Panse, Wolfgang R Sperr, Peter Valent, Andreas Reiter, Juliana Schwaab
Certain laboratory abnormalities correlate with subvariants of systemic mastocytosis (SM) and are often prognostically relevant. To assess the diagnostic and prognostic value of individual serum chemistry parameters in SM, 2607 patients enrolled within the European Competence Network on Mastocytosis (ECNM) and 575 patients enrolled within the German Registry on Eosinophils and Mast Cells (GREM) were analyzed. For screening and diagnosis of SM, tryptase was identified as the most specific serum parameter. For differentiation between indolent and advanced SM (AdvSM), the following serum parameters were most relevant: tryptase, alkaline phosphatase (AP), ß2-microglobulin, lactate dehydrogenase (LDH), albumin, vitamin B12, and C-reactive protein (P<0...
April 9, 2024: Blood Advances
#24
JOURNAL ARTICLE
Julia Mai, Dmitrii Lachinov, Gregor S Reiter, Sophie Riedl, Christoph Grechenig, Hrvoje Bogunovic, Ursula Schmidt-Erfurth
OBJECTIVE: To identify the individual progression of geographic atrophy (GA) lesions from baseline OCT images of patients in routine clinical care. DESIGN: Clinical evaluation of a deep learning-based algorithm. SUBJECTS: One hundred eighty-four eyes of 100 consecutively enrolled patients. METHODS: OCT and fundus autofluorescence (FAF) images (both Spectralis, Heidelberg Engineering) of patients with GA secondary to age-related macular degeneration in routine clinical care were used for model validation...
2024: Ophthalmol Sci
#25
JOURNAL ARTICLE
Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Maryline Kouba, Marta López-Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Roberto Edoardo Villa, Ruud Woutersen, Jaume Galobart, Fabiola Pizzo, Maria Vittoria Vettori, Paola Manini
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP Panel) was asked to deliver a scientific opinion on the safety for the users of the feed additive consisting of ferric tyrosine chelate (TYFER™) when used as a zootechnical additive for chickens, turkeys and minor poultry species for fattening or reared for laying/breeding. The European Commission request follows a previous opinion of the FEEDAP Panel. In that opinion, the Panel identified several risks for the users of the additive; it was listed that it posed a risk to users by inhalation, should be considered as an irritant to skin, eyes and mucous membranes, and also that, due to its nickel content, should be considered as a dermal and respiratory sensitiser...
April 2024: EFSA journal
#26
REVIEW
Virginia Mares, Marcio B Nehemy, Hrvoje Bogunovic, Sophie Frank, Gregor S Reiter, Ursula Schmidt-Erfurth
Artificial intelligence (AI) has emerged as a transformative technology across various fields, and its applications in the medical domain, particularly in ophthalmology, has gained significant attention. The vast amount of high-resolution image data, such as optical coherence tomography (OCT) images, has been a driving force behind AI growth in this field. Age-related macular degeneration (AMD) is one of the leading causes for blindness in the world, affecting approximately 196 million people worldwide in 2020...
April 8, 2024: International Journal of Retina and Vitreous
#27
JOURNAL ARTICLE
Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Maryline Kouba, Marta López-Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Roberto Edoardo Villa, Ruud Woutersen, Anna Dioni, Joana Firmino, Matteo Innocenti, Jordi Tarrés-Call
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l-isoleucine produced by fermentation with Corynebacterium glutamicum CGMCC 20437 as a nutritional feed additive for use in feed and in water for drinking for all animal species. The production strain is non-genetically modified, qualifies for the QPS approach to safety assessment when used for production purposes, is susceptible to the relevant antibiotics and contains no antimicrobial resistance genes of concern...
April 2024: EFSA journal
#28
Dong Liu, Zhiqiang Ma, Shouyin Di, Yang Yang, Jingang Yang, Liqun Xu, Russel J Reiter, Shubin Qiao, Jiansong Yuan
No abstract text is available yet for this article.
April 4, 2024: Free Radical Biology & Medicine
#29
JOURNAL ARTICLE
C Kalisch, M Reiter, M Krieger, L Wüst, C Klotz, R Dekant, D W Lachenmeier, O Scherf-Clavel, A Mally
Humans are chronically exposed to furan, a potent liver toxicant and carcinogen that occurs in a variety of heat-processed foods. Assessment of human exposure based on the furan content in foods is, however, subject to some uncertainty due to the high volatility of furan. Biomarker monitoring is thus considered an alternative or complementary approach to furan exposure assessment. Previous work suggested that urinary furan metabolites derived from the reaction of cis-2-butene-1,4-dial (BDA), the reactive intermediate of furan, with glutathione (GSH) or amino acids may serve as potential biomarkers of furan exposure...
April 4, 2024: Archives of Toxicology
#30
JOURNAL ARTICLE
Evan Dimentberg, Marie-Pier Marceau, Alexandre Lachance, Samuel Bergeron-Gravel, Stephan Saikali, Louis Crevier, Catherine Bourget, Cynthia Hawkins, Nada Jabado, Panagiota Giannakouros, Samuele Renzi, Valérie Larouche
Diffuse intrinsic pontine gliomas are lethal tumors with a prognosis generally less than 1 year. Few cases of survivors of 5 years or more have been reported. This case report highlights the journey of a 9.5-year survivor who underwent 3 rounds of focal radiotherapy; she experienced 6 years of progression-free survival following the first round but ultimately succumbed to her disease. An autopsy revealed a favorable IDH1 mutation and the absence of H3K27M. This case reiterates the importance of extensive molecular analyses in diffuse intrinsic pontine gliomas and explores the potential benefit of re-irradiation in patients with positive responses and long periods of remission...
April 4, 2024: Journal of Pediatric Hematology/oncology
#31
JOURNAL ARTICLE
Andreas W Oehm, Anton Reiter, Angela Binz, Manuela Schnyder
No abstract text is available yet for this article.
April 4, 2024: Parasitology
#32
JOURNAL ARTICLE
Phillip B Wyatt, Charles R Reiter, James R Satalich, Conor N O'Neill, Alexander R Vap
BACKGROUND: Anatomical total shoulder arthroplasty (TSA) and shoulder hemiarthroplasty (HA) have both been shown to have good outcomes in patients with osteoarthritis of the glenohumeral joint. However, evidence comparing perioperative complications between these procedures in this population is heterogeneous. MATERIALS AND METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was queried between the years 2012 and 2021 (10 years in total) for records of patients who underwent either TSA or HA for osteoarthritis of the glenohumeral joint...
April 4, 2024: Orthopedics
#33
JOURNAL ARTICLE
Sandra Goetze, Audrey van Drogen, Jonas B Albinus, Kyle L Fort, Tejas Gandhi, Damiano Robbiani, Véronique Laforte, Lukas Reiter, Mitchell P Levesque, Yue Xuan, Bernd Wollscheid
BACKGROUND: Clinical samples are irreplaceable, and their transformation into searchable and reusable digital biobanks is critical for conducting statistically empowered retrospective and integrative research studies. Currently, mainly data-independent acquisition strategies are employed to digitize clinical sample cohorts comprehensively. However, the sensitivity of DIA is limited, which is why selected marker candidates are often additionally measured targeted by parallel reaction monitoring...
April 2, 2024: Clinical Proteomics
#34
JOURNAL ARTICLE
Niamh Bridget Moloney, Jessica Ong, Neha Irani
We discuss a patient who presented with bilateral VI and VII cranial nerve palsies, symmetric upper and lower limb weakness and areflexia, 2 weeks following an flu-like illness. At presentation, there was no papilloedema, and her visual function was normal. Cerebrospinal fluid analysis and electrophysiology supported the diagnosis of Guillain-Barré Syndrome (GBS). She received intravenous immunoglobulins. She subsequently developed headaches and vision loss. Funduscopy demonstrated severe papilloedema with visual acuity of 6/18 right eye, 6/12 left eye with bitemporal visual field depression...
April 1, 2024: BMJ Case Reports
#35
REVIEW
Sanjay Singh Rawat, Ashverya Laxmi
Cell cycle involves the sequential and reiterative progression of important events leading to cell division. Progression through a specific phase of the cell cycle is under the control of various factors. Since the cell cycle in multicellular eukaryotes responds to multiple extracellular mitogenic cues, its study in higher forms of life becomes all the more important. One such factor regulating cell cycle progression in plants is sugar signalling. Because the growth of organs depends on both cell growth and proliferation, sugars sensing and signalling are key control points linking sugar perception to regulation of downstream factors which facilitate these key developmental transitions...
2024: Frontiers in Plant Science
#36
JOURNAL ARTICLE
Katrine Worsaae, Alice Rouan, Elaine Seaver, Norio Miyamoto, Ekin Tilic
Most species of the bone-devouring marine annelid, Osedax, display distinct sexual dimorphism with macroscopic sedentary females rooted in bones and free-living microscopic dwarf males. The paedomorphic male resembles the non-feeding metatrochophore larva in size, presence of eight pairs of chaetae, and a head ciliation potentially representing a residual prototroch. The male development may thus uniquely reiterate and validate the theoretical heterochrony process "progenesis", which suggests that an accelerated sexual maturation and early arrest of somatic growth can lead to a miniaturized and paedomorphic adult...
2024: Frontiers in Neuroscience
#37
JOURNAL ARTICLE
Tim Knochenhauer, Andreas Schaefer, Jens Brickwedel, Beate Reiter, Shiho Naito, Svante Zipfel, Yvonne Schneeberger, Hermann Reichenspurner, Bjoern Sill
BACKGROUND: Deep sternal wound infection (DSWI) remains a serious complication after coronary artery bypass grafting (CABG). We herein aimed to stratify diabetic patients who underwent CABG using bilateral internal mammary artery (BIMA) for levels of glycated hemoglobin A1C (HbA1c) and compare postoperative outcomes. METHODS: Between January 2010 and August 2020, 4,186 consecutive patients underwent isolated CABG at our center. In 3,229 patients, preoperative HbA1c levels were available...
2024: Frontiers in Cardiovascular Medicine
#38
JOURNAL ARTICLE
Charles R Reiter, Vivek M Abraham, Daniel L Riddle, Nirav K Patel, Ashton H Goldman
BACKGROUND: Significant heterogeneity exists regarding patient reported outcome measures (PROMs) used in total hip (THA) and knee (TKA) arthroplasty randomized controlled trials (RCTs). This study investigates the PROMs used as primary and secondary outcomes in contemporary arthroplasty RCTs. METHODS: A literature search identified THA and TKA RCTs that were published in top ten impact factor orthopaedic journals from 2017 to 2021. Screening identified 241 trials: 76 THA, 157 TKA, and eight combined...
April 1, 2024: Archives of Orthopaedic and Trauma Surgery
#39
Eun Joo Kim, Mi-Seon Kong, Sanggeon Park, Jeiwon Cho, Jeansok J Kim
Pavlovian fear conditioning research suggests that the interaction between the dorsal periaqueductal gray (dPAG) and basolateral amygdala (BLA) acts as a prediction error mechanism in the formation of associative fear memories. However, their roles in responding to naturalistic predatory threats, characterized by less explicit cues and the absence of reiterative trial-and-error learning events, remain unexplored. In this study, we conducted single-unit recordings in rats during an 'approach food-avoid predator' task, focusing on the responsiveness of dPAG and BLA neurons to a looming robot predator...
March 11, 2024: bioRxiv
#40
JOURNAL ARTICLE
Flor Alvarado, Farah Allouch, Jodie Laurent, Jing Chen, Joshua D Bundy, Jeanette Gustat, Deidra C Crews, Katherine T Mills, Keith C Ferdinand, Jiang He
BACKGROUND: Favorable neighborhood-level social determinants of health (SDoH) are associated with lower cardiovascular disease risk. Less is known about their influence on cardioprotective behaviors. We evaluated the associations between neighborhood-level SDoH and cardioprotective behaviors among church members in Louisiana. METHODS: Participants were surveyed between November 2021 to February 2022, and were asked about health behaviors, aspects of their neighborhood, and home address (to link to census tract and corresponding social deprivation index [SDI] data)...
March 29, 2024: American Journal of the Medical Sciences
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